Takahisa Murata

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function
    Pascal N Bernatchez
    Department of Pharmacology and Vascular Biology and Transplantation Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 282:30745-53. 2007
  2. ncbi Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension
    Takahisa Murata
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Bunkyo ku, Japan
    J Biol Chem 277:44085-92. 2002
  3. doi Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells
    Taiki Kida
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 33:1663-9. 2013
  4. doi Increased contractility of hepatic stellate cells in cirrhosis is mediated by enhanced Ca2+-dependent and Ca2+-sensitization pathways
    Masateru Iizuka
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
    Am J Physiol Gastrointest Liver Physiol 300:G1010-21. 2011
  5. doi Chronic treatment with PDGF-BB and endothelin-1 synergistically induces vascular hyperplasia and loss of contractility in organ-cultured rat tail artery
    Taiki Kida
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Atherosclerosis 214:288-94. 2011
  6. doi Opposing immunomodulatory roles of prostaglandin D2 during the progression of skin inflammation
    Hana Sarashina
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    J Immunol 192:459-65. 2014
  7. ncbi Statin protects endothelial nitric oxide synthase activity in hypoxia-induced pulmonary hypertension
    Takahisa Murata
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Arterioscler Thromb Vasc Biol 25:2335-42. 2005
  8. ncbi Halichlorine reduces monocyte adhesion to endothelium through the suppression of nuclear factor-kappaB activation
    Yoshiki Tsubosaka
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
    J Pharmacol Sci 113:208-13. 2010
  9. pmc Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement
    Takahisa Murata
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Tokyo 113 8657, Japan
    Proc Natl Acad Sci U S A 110:5205-10. 2013
  10. doi Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway
    Koji Kobayashi
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 33:565-71. 2013

Collaborators

Detail Information

Publications49

  1. ncbi Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function
    Pascal N Bernatchez
    Department of Pharmacology and Vascular Biology and Transplantation Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 282:30745-53. 2007
    ..These data are the first to report novel biological activities for myoferlin and reveal the role of membrane integrity to VEGF signaling...
  2. ncbi Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension
    Takahisa Murata
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Bunkyo ku, Japan
    J Biol Chem 277:44085-92. 2002
    ..In conclusion, chronic hypoxia impairs endothelial Ca(2+) metabolism and normal coupling between eNOS and caveolin-1 resulted in eNOS inactivity...
  3. doi Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells
    Taiki Kida
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 33:1663-9. 2013
    ..TGR5 is a G-protein-coupled receptor for bile acids. So far, little is known about the function of TGR5 in vascular endothelial cells...
  4. doi Increased contractility of hepatic stellate cells in cirrhosis is mediated by enhanced Ca2+-dependent and Ca2+-sensitization pathways
    Masateru Iizuka
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
    Am J Physiol Gastrointest Liver Physiol 300:G1010-21. 2011
    ..These results suggest that activated HSCs may participate in constriction of hepatic sinusoids in the cirrhotic liver through both Ca(2+)-dependent (MLCK pathway) and Ca(2+)-sensitization mechanism (CPI-17 and MYPT1 pathways)...
  5. doi Chronic treatment with PDGF-BB and endothelin-1 synergistically induces vascular hyperplasia and loss of contractility in organ-cultured rat tail artery
    Taiki Kida
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Atherosclerosis 214:288-94. 2011
    ..In this study, we examined the synergistic effects of the two potent pathogenic factors, platelet-derived growth factor-BB (PDGF-BB) and endothelin-1 (ET-1) to induce vascular hyperplasia using ex vivo organ-culture system...
  6. doi Opposing immunomodulatory roles of prostaglandin D2 during the progression of skin inflammation
    Hana Sarashina
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    J Immunol 192:459-65. 2014
    ..DP-mediated vascular barrier enhancement or CRTH2-mediated neutrophil activation may be responsible for these effects. Thus, PGD2 represents opposite roles in inflammation, depending on the disease phase in vivo. ..
  7. ncbi Statin protects endothelial nitric oxide synthase activity in hypoxia-induced pulmonary hypertension
    Takahisa Murata
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Arterioscler Thromb Vasc Biol 25:2335-42. 2005
    ..We investigated the effects of fluvastatin on hypoxia-induced (1 to 3 weeks, 10% O2) pulmonary hypertension with focus on endothelial nitric oxide synthase (eNOS) activity...
  8. ncbi Halichlorine reduces monocyte adhesion to endothelium through the suppression of nuclear factor-kappaB activation
    Yoshiki Tsubosaka
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
    J Pharmacol Sci 113:208-13. 2010
    ..Herein, we provided the first evidence that halichlorine inhibits LPS-induced NF-kappaB activation, which results in the suppression of VCAM-1, ICAM-1, and E-selectin gene expression and monocyte-adhesion to endothelial cells...
  9. pmc Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement
    Takahisa Murata
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Tokyo 113 8657, Japan
    Proc Natl Acad Sci U S A 110:5205-10. 2013
    ....
  10. doi Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway
    Koji Kobayashi
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 33:565-71. 2013
    ..Prostaglandin D(2) (PGD(2)) is one of the prostanoids produced during inflammation. Although PGD(2) is known to decrease endothelial permeability through D prostanoid (DP) receptor stimulation, the detailed mechanism is unknown...
  11. pmc EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals
    Tsuyoshi Tajima
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
    Am J Physiol Gastrointest Liver Physiol 302:G524-34. 2012
    ..NO produced in muscularis macrophages induces dysmotility during gastrointestinal inflammation...
  12. doi iNOS expression in vascular resident macrophages contributes to circulatory dysfunction of splanchnic vascular smooth muscle contractions in portal hypertensive rats
    Masahiro Kajita
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 300:H1021-31. 2011
    ....
  13. ncbi Dexamethasone prevents impairment of endothelium-dependent relaxation in arteries cultured with fetal bovine serum
    Takahisa Murata
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8675, Japan
    Eur J Pharmacol 515:134-41. 2005
    ....
  14. doi Chronic stimulation of farnesoid X receptor impairs nitric oxide sensitivity of vascular smooth muscle
    Taiki Kida
    Dept of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The Univ of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Am J Physiol Heart Circ Physiol 296:H195-201. 2009
    ..These results suggest that chronic stimulation of FXR impairs endothelium-dependent relaxation, which is due to decreased sensitivity of smooth muscle cells to nitric oxide...
  15. pmc UDP induces intestinal epithelial migration via the P2Y6 receptor
    Tatsuro Nakamura
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, 113 8657, Japan
    Br J Pharmacol 170:883-92. 2013
    ..In this study, we investigated the role of extracellular nucleotides in intestinal epithelial migratory responses...
  16. doi Purinergic P2Y1 receptor signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts
    Koichi Iwanaga
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo 113 8657, Japan
    Eur J Pharmacol 702:158-64. 2013
    ..We also revealed that inhibitors of p38 MAPK and PKC inhibited ATPγS-induced COX-2 mRNA expression. Collectively, purinergic P2Y1 receptor signaling mediates wound-induced COX-2 expression through p38 MAPK and PKC pathways in ISMFs...
  17. doi Prostaglandin E2 promotes wound-induced migration of intestinal subepithelial myofibroblasts via EP2, EP3, and EP4 prostanoid receptor activation
    Koichi Iwanaga
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Pharmacol Exp Ther 340:604-11. 2012
    ..PGE(2)-EP3 signaling may directly stimulate ISMF migration. PGE(2)-EP2/4 signaling indirectly stimulates ISMF migration by elevating the level of growth factor secretion...
  18. ncbi Prostaglandin D2 inhibits collagen secretion from lung fibroblasts by activating the DP receptor
    Shinya Ayabe
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
    J Pharmacol Sci 121:312-7. 2013
    ..These results suggest that PGD2 inhibits TGF-β-induced collagen secretion via intracellular cAMP accumulation through activating DP receptor...
  19. pmc Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma
    Takahisa Murata
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Tokyo 113 8657, Japan
    Proc Natl Acad Sci U S A 108:19802-7. 2011
    ..Mast cell-derived PGD(2) governs the tumor microenvironment by restricting excessive responses to vascular permeability and TNF-α production...
  20. doi Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level
    Masanori Fujimoto
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    Eur J Pharmacol 602:432-8. 2009
    ..The statin-induced inhibitory action may be mediated by the suppression of geranylgeranyl transferase via the depletion of intracellular mevalonic acid...
  21. pmc Role of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo
    Takahisa Murata
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Tokyo 133 8657, Japan
    Proc Natl Acad Sci U S A 105:20009-14. 2008
    ..Our results identify PGD(2)/DP receptor as a new regulator of tumor vascular permeability, indicating DP agonism may be exploited as a potential therapy for the treatment of cancer...
  22. ncbi Time-dependent phenotypic and contractile changes of pulmonary artery in chronic hypoxia-induced pulmonary hypertension
    Daigo Aoshima
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Tokyo, Japan
    J Pharmacol Sci 110:182-90. 2009
    ....
  23. doi Prostaglandin E2-prostanoid EP3 signal induces vascular contraction via nPKC and ROCK activation in rat mesenteric artery
    Koji Kobayashi
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Eur J Pharmacol 660:375-80. 2011
    ..Prostanoid EP3-mediated contraction is ascribed to Ca2+-independent contractile pathway including PKCδ, ε and ROCK...
  24. ncbi Vascular endothelium has a local anti-adenovirus vector system and glucocorticoid optimizes its gene transduction
    Takahisa Murata
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Arterioscler Thromb Vasc Biol 25:1796-803. 2005
    ..We investigated the mechanisms of this impairment and the effect of dexamethasone (DEX) on gene transfer into the vascular endothelial cells...
  25. doi ATP induces contraction mediated by the P2Y(2) receptor in rat intestinal subepithelial myofibroblasts
    Tatsuro Nakamura
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo 113 8657, Japan
    Eur J Pharmacol 657:152-8. 2011
    ..These results suggest that ATP induces [Ca(2+)](i)-dependent contraction in IMFs, which is mediated through the P2Y(2) receptor...
  26. ncbi Prostaglandin D(2) induces contraction via thromboxane A(2) receptor in rat liver myofibroblasts
    Tomoharu Maruyama
    Department of Veterinary Pharmacology, Agriculture and Life Science, The University of Tokyo, Japan
    Eur J Pharmacol 591:237-42. 2008
    ..Additionally, we observed that BW245C (1-10 microM) decreased basal MF contraction. These results suggest that PGD(2) induces rat liver MF contraction with an increase in [Ca(2+)](i) through prostanoid TP receptor...
  27. ncbi Isolation and characterization of bovine intestinal subepithelial myofibroblasts
    Koichi Iwanaga
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
    J Pharmacol Sci 112:98-104. 2010
    ..Thus, bovine ISMFs might be a novel useful tool with long life span and good cellular responses to investigate physiological/pathophysiological roles of ISMFs...
  28. doi γ-Oryzanol reduces adhesion molecule expression in vascular endothelial cells via suppression of nuclear factor-κB activation
    Satoshi Sakai
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Agric Food Chem 60:3367-72. 2012
    ..Collectively, our results suggested that γ-ORZ reduced LPS-mediated adhesion molecule expression through NF-κB inhibition in vascular endothelium...
  29. pmc Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus
    Yasuaki Tsuchida
    Department of Veterinary Pharmacology, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Gut 60:638-47. 2011
    ..Prokinetic 5-hydroxytryptamine 4 receptor (5-HT₄R) agonists and dopamine receptor antagonists are potential therapeutic agents for directly ameliorating the motility disorder associated with POI...
  30. ncbi Halichlorine is a novel L-type Ca(2+) channel inhibitor isolated from the marine sponge Halichondria okadai Kadota
    Yoshiki Tsubosaka
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Eur J Pharmacol 628:128-31. 2010
    ..58+/-0.07pA/pF for halichlorine). These results suggest that halichlorine inhibits L-type Ca(2+) channels in vascular smooth muscle cells, which inhibit intracellular Ca(2+) influx, and then reduce vascular contractions...
  31. ncbi Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice
    Koichi Iwanaga
    Authors Affiliations Departments of Animal Radiology and Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo and Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan
    Cancer Res 74:3011-9. 2014
    ..Together, our results identified mast cell-derived PGD2 as an inhibitor of colitis and CAC, with implications for its potential use in preventing or treating colon cancer...
  32. ncbi Stimulation of G Protein-Coupled Bile Acid Receptor Enhances Vascular Endothelial Barrier Function via Activation of Protein Kinase A and Rac1
    Taiki Kida
    Department of Veterinary Pharmacology T K, K O, M H, H O, T M and Department of Animal Radiology T M, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
    J Pharmacol Exp Ther 348:125-30. 2014
    ..These results indicate that stimulation of GPBAR enhances endothelial barrier function by cAMP/PKA/Rac1-dependent cytoskeletal rearrangement. ..
  33. ncbi Dexamethasone blocks hypoxia-induced endothelial dysfunction in organ-cultured pulmonary arteries
    Takahisa Murata
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    Am J Respir Crit Care Med 170:647-55. 2004
    ....
  34. doi Sphingosine-1-phosphate enhances IL-1{beta}-induced COX-2 expression in mouse intestinal subepithelial myofibroblasts
    Takashi Ohama
    Dept of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The Univ of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Am J Physiol Gastrointest Liver Physiol 295:G766-75. 2008
    ..In SEMFs, S1P amplifies IL-1beta-induced COX-2 expression through increased mRNA stability. These observations point to involvement of S1P in activation of SEMFs that may contribute to intestinal inflammation and carcinogenesis...
  35. doi Downregulation of CPI-17 contributes to dysfunctional motility in chronic intestinal inflammation model mice and ulcerative colitis patients
    Takashi Ohama
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Gastroenterol 43:858-65. 2008
    ..However, its clinical relevance has not been clarified...
  36. ncbi Relaxant effect of prostaglandin D(2)--receptor DP agonist on liver myofibroblast contraction
    Tomoharu Maruyama
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
    J Pharmacol Sci 116:197-203. 2011
    ..These results suggest that prostanoid DP receptor agonism inhibits bradykinin-induced [Ca(2+)](i) elevation and contraction through cAMP-PKA signal activation in rat liver MFs...
  37. ncbi Stromal Cell-Derived Factor-1α/C-X-C Chemokine Receptor Type 4 Axis Promotes Endothelial Cell Barrier Integrity via Phosphoinositide 3-Kinase and Rac1 Activation
    Koji Kobayashi
    From the Departments of Animal Radiology K K, K O, T M and Veterinary Pharmacology K S, T K, M H, H O, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 34:1716-22. 2014
    ..We have investigated here the role of SDF-1αsignaling in endothelial barrier function...
  38. ncbi Diverse effects of prostaglandin E₂ on vascular contractility
    Taiki Kida
    Department of Veterinary Pharmacology and Animal Radiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Heart Vessels 29:390-5. 2014
    ..Taken together, PGE₂ causes different contractile responses depending on the type of vascular bed. This phenomenon may be due to the difference in expression pattern and activity of EP receptors...
  39. doi The 5-HT4 receptor agonist mosapride attenuates NSAID-induced gastric mucosal damage
    Masahiko Fujisawa
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    J Gastroenterol 45:179-86. 2010
    ..In this study, we tested the hypothesis that cholinergic nerve stimulation by a 5-HT(4) agonist may modulate the progression of gastric mucosal ulcers induced by nonsteroidal anti-inflammatory drugs (NSAIDs)...
  40. ncbi Carbachol induces Ca(2+)-dependent contraction via muscarinic M2 and M3 receptors in rat intestinal subepithelial myofibroblasts
    Koichi Iwanaga
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
    J Pharmacol Sci 110:306-14. 2009
    ..Furthermore, AF-DX116 and 4-DAMP dose-dependently inhibited the carbachol-induced [Ca(2+)](i) elevation. These observations suggest that acetylcholine elicits Ca(2+)-dependent IMF contraction through muscarinic M(2) and M(3) receptors...
  41. ncbi Fluvastatin prevents vascular hyperplasia by inhibiting phenotype modulation and proliferation through extracellular signal-regulated kinase 1 and 2 and p38 mitogen-activated protein kinase inactivation in organ-cultured artery
    Kenichi Sakamoto
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
    Arterioscler Thromb Vasc Biol 25:327-33. 2005
    ..We examined the inhibitory mechanisms of fluvastatin on FBS-induced vascular hypertrophy assessed by organ-cultured rat tail artery...
  42. doi Lipopolysaccharide induces macrophage migration via prostaglandin D(2) and prostaglandin E(2)
    Tsuyoshi Tajima
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Pharmacol Exp Ther 326:493-501. 2008
    ....
  43. ncbi Antioxidant, free radical-scavenging, and NF-kappaB-inhibitory activities of phytosteryl ferulates: structure-activity studies
    Md Shafiqul Islam
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
    J Pharmacol Sci 111:328-37. 2009
    ..7 macrophages. These observations revealed that phytosteryl ferulates are responsible for the antioxidant and anti-inflammatory activity via ROS scavenging and inhibition of ROS production...
  44. pmc Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice
    Takahisa Murata
    Department of Pharmacology and Program in Vascular Cell Signaling and Therapeutics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06511
    J Exp Med 204:2373-82. 2007
    ..These results provide clear physiological evidence supporting the important role of cell type-specific Cav-1 expression governing multiple phenotypes in the vasculature, heart, and lung...
  45. pmc Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve
    Jun Yu
    Department of Pharmacology and Vascular Cell Signaling and Therapeutics Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 102:10999-1004. 2005
    ..Collectively, our data suggest that endogenous eNOS-derived NO exerts direct effects in preserving blood flow, thereby promoting arteriogenesis, angiogenesis, and mural cell recruitment to immature angiogenic sprouts...
  46. ncbi Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells
    Takahisa Murata
    Department of Pharmacology and Program in Vascular Cell Signaling and Therapeutics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 282:16631-43. 2007
    ..Thus, Cav-1 is required for calcium entry in vascular endothelial cells and perhaps other specialized cell types containing caveolae...
  47. ncbi Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth
    Michelle I Lin
    Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University, New Haven, Connecticut 06536, USA
    Cancer Res 67:2849-56. 2007
    ..Thus, the loss of Cav-1 increases tumor permeability and growth and that may relate to enhanced VEGF signaling due to lack of Cav-1 inhibition of VEGFR-2 or decreased VE-cadherin mediated VEGFR-2 phosphorylation...
  48. pmc Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels
    Jun Yu
    Department of Pharmacology and Program in Vascular Cell Signaling and Therapeutics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Clin Invest 116:1284-91. 2006
    ..In conclusion, these results showed that endothelial Cav-1 and caveolae are necessary for both rapid and long-term mechanotransduction in intact blood vessels...
  49. pmc The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo
    Dmitriy N Atochin
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, MA 02129, USA
    J Clin Invest 117:1961-7. 2007
    ..They also demonstrate the in vivo relevance of posttranslational modification of eNOS in vascular function...