Research Topics
Genomes and Genes
| Hozumi MotohashiSummaryAffiliation: University of Tsukuba Country: Japan Publications
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Detail Information
Publications
MafG sumoylation is required for active transcriptional repressionHozumi Motohashi
Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
Mol Cell Biol 26:4652-63. 2006....- Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genesFumiki Katsuoka
Center for TARA, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
Mol Cell Biol 25:8044-51. 2005..These data explicitly demonstrate that small Mafs play critical roles in the inducible expression of a significant portion of ARE-dependent genes... 
Nrf2 transcriptionally activates the mafG gene through an antioxidant response elementFumiki Katsuoka
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305 8577, Japan
J Biol Chem 280:4483-90. 2005..These results demonstrate that mafG is itself an ARE-dependent gene that is regulated by an Nrf2/small Maf heterodimer and suggest the presence of an autoregulatory feedback pathway for mafG transcriptional regulation...- Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimerMomoko Kimura
Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8572, Japan
J Biol Chem 282:33681-90. 2007..Our contention is supported that the differential DNA binding specificity between Maf homodimers and Nrf2-Maf heterodimers establishes the differential gene regulation by these dimer-forming transcription factors... - Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathwayHozumi Motohashi
Institute of Basic Medical Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305 8577, Japan
Proc Natl Acad Sci U S A 101:6379-84. 2004..This rescue phenotype of mafG::mafF::keap1 triple compound mutant mice phenocopies that of the nrf2::keap1 compound mutant mice, indicating that the small Maf proteins MafG and MafF must functionally cooperate with Nrf2 in vivo... - Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesionsMasafumi Tauchi
Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance TARA, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
Mol Cell Biol 25:9360-8. 2005..We demonstrate that constitutive activation of the AhR pathway causes inflammatory skin lesions and suggests a new mechanism for the exacerbation of inflammatory diseases after exposure to occupational and environmental xenobiotics... - Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient miceTomonori Hosoya
Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8577, Japan
Biochem Biophys Res Commun 365:562-7. 2008.... - Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcationHarumi Y Mukai
Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305 8577, Japan
Mol Cell Biol 26:7953-65. 2006.... - Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicityHiromi Okawa
Graduate School of Comprehensive Human Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
Biochem Biophys Res Commun 339:79-88. 2006..These results demonstrate that chronic activation of Nrf2 confers animals with resistance to xenobiotics without affecting the morphological and physiological integrity of hepatocytes... - Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elementsTae Yamamoto
Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
Genes Cells 11:575-91. 2006..This study thus manifests that a clear set of rules pertaining to the cis-acting element determine whether a given MARE preferentially associates with MafG homodimer or with MafG:Nrf2 heterodimer... - Nrf2-Keap1 defines a physiologically important stress response mechanismHozumi Motohashi
Center for Tsukuba Advanced Research Alliance, Exploratory Research for Advanced Technology-Japan Science and Technology Corporation, University of Tsukuba, Tsukuba 305-8577, Japan
Trends Mol Med 10:549-57. 2004..Furthermore, extensive studies have suggested that the Nrf2-Keap1 system contributes to protection against various pathologies, including carcinogenesis, liver toxicity, respiratory distress and inflammation... - Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2Takafumi Suzuki
Exploratory Research for Advanced Technology Environmental Response Project, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Japan
J Biol Chem 283:2021-30. 2008..Our results thus demonstrate that reduced selenoprotein activity is counterbalanced by an Nrf2-mediated cytoprotective response, which is essential for maintaining cellular redox homeostasis and viability... - Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytesKeiko Nohara
Environmental Health Sciences Division, National Institute for Environmental Studies, University of Tsukuba, Tsukuba, Japan
J Immunol 174:2770-7. 2005..They also indicate that AhR activation in T cells and not in B cells suppresses the immunization-induced increase in both T cells and B cells... - Identification of polymorphisms in the promoter region of the human NRF2 geneTae Yamamoto
Graduate School of Comprehensive Human Sciences, Majors of Medical Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
Biochem Biophys Res Commun 321:72-9. 2004..However, available lines of evidence suggest the importance of examining the link between NRF2 polymorphisms and other oxidative stress-related diseases... - Small Maf compound mutants display central nervous system neuronal degeneration, aberrant transcription, and Bach protein mislocalization coincident with myoclonus and abnormal startle responseFumiki Katsuoka
Institute of Basic Medical Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305 8577, Japan
Mol Cell Biol 23:1163-74. 2003..Thus compound mafG::mafK mutants develop age- and maf gene dosage-dependent cell-autonomous neuronal deficiencies that lead to profound neurological defects... - Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activationNobunao Wakabayashi
Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
Nat Genet 35:238-45. 2003..Breeding to Nrf2-deficient mice reversed the phenotypic Keap1 deficiencies. These experiments show that Keap1 acts upstream of Nrf2 in the cellular response to oxidative and xenobiotic stress... - Identification and characterization of 2 types of erythroid progenitors that express GATA-1 at distinct levelsNorio Suzuki
Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
Blood 102:3575-83. 2003..This study also presents an efficient method for enriching the CFU-E and BFU-E from mouse hematopoietic tissues... - Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genesJianyong Zhang
Graduate School of Comprehensive Human Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
Biochem J 404:459-66. 2007..Taken together, these results indicate that the Neh5 domain has the ability to regulate Nrf2 target gene transcription, yet the role of the Neh5 domain in transcription varies from gene to gene... - Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouseTakashi Moriguchi
Institute of Basic Medical Sciences, Center for Tsukuba Advanced Research Alliance, and Exploratory Research for Advanced Technology Environmental Response Project, University of Tsukuba, Tsukuba 305 8575, Japan
Proc Natl Acad Sci U S A 100:5652-7. 2003..Thus, the hAHR knock-in mouse is a humanized model mouse that may better predict the biological effects of bioaccumulative environmental toxicants like TCDD in humans... - [Small Maf proteins as transcription factors regulating maturation and maintenance of the cell]Hozumi Motohashi
Center for Tsukuba Advanced Research Alliance, Institute of Basic Medical Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba 305-8577, Japan
Seikagaku 75:1193-201. 2003 - Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factorsHozumi Motohashi
Institute of Basic Medical Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 305-8577, Tsukuba, Japan
Gene 294:1-12. 2002..Deciphering the molecular basis of the regulatory network composed of Maf and CNC families of transcription factors will undoubtedly lead to a new paradigm for the cooperative function of transcription factors... - Carcinogenesis and transcriptional regulation through Maf recognition elementsHozumi Motohashi
Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
Cancer Sci 98:135-9. 2007..On the contrary, the constitutive activation of Nrf2 due to mutations in the keap1 gene is characteristically observed in lung cancer cells, suggesting that induced expression of Nrf2 target genes favors the prevalence of cancer cells... - Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouseShuhei Noda
Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
Biochem Biophys Res Commun 303:105-11. 2003..Here, we report an initial characterization of the AhR-Nrf2 double mutant mice, which may serve as a simplified bioassay system to evaluate xenobiotic toxicity and metabolic biotransformation of various drugs and environmental chemicals... - Solution structure of the DNA-binding domain of MafGHideki Kusunoki
Institute of Basic Medical Science, University of Tsukuba, Tsukuba, Ibaraki 305 8575 Japan
Nat Struct Biol 9:252-6. 2002..The structural similarity between MafG and Skn-1 enables us to propose a possible mechanism by which Maf family proteins recognize their consensus DNA sequences... - Evaluation of MafG interaction with Maf recognition element arrays by surface plasmon resonance imaging techniqueMotoki Kyo
TOYOBO Co. Ltd. Bio 21 Project, 10-24 Toyo-cho, Tsuruga, Fukui 914-0047, Japan
Genes Cells 9:153-64. 2004..These results demonstrate that the double-stranded DNA array fabricated with the modified multistep procedure can be applied for the comprehensive analysis of the transcription factor-DNA interaction... - Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survivalMi Kyoung Kwak
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
J Biol Chem 278:8135-45. 2003.... - Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activityTae Yamamoto
Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai 980 8575, Japan
Mol Cell Biol 28:2758-70. 2008..These results demonstrate critical roles of the cysteine residues in vivo in maintaining Keap1 function, such that Nrf2 is repressed under quiescent conditions and active in response to oxidants/electrophiles...