Naoki Mori

Summary

Affiliation: University of the Ryukyus
Country: Japan

Publications

  1. pmc Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-kappaB activation
    Masaya Higuchi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Retrovirology 2:29. 2005
  2. ncbi request reprint Cell signaling modifiers for molecular targeted therapy in ATLL
    Naoki Mori
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Front Biosci (Landmark Ed) 14:1479-89. 2009
  3. ncbi request reprint Elevated expression of CCL5/RANTES in adult T-cell leukemia cells: possible transactivation of the CCL5 gene by human T-cell leukemia virus type I tax
    Naoki Mori
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Int J Cancer 111:548-57. 2004
  4. pmc Apoptosis induced by the histone deacetylase inhibitor FR901228 in human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells
    Naoki Mori
    Division of Molecular Virology and Oncology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0215, Japan
    J Virol 78:4582-90. 2004
  5. pmc Helicobacter pylori induces RANTES through activation of NF-kappa B
    Naoki Mori
    Department of Virology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Infect Immun 71:3748-56. 2003
  6. ncbi request reprint Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB
    Naoki Mori
    Department of Virology, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Int J Cancer 105:661-8. 2003
  7. ncbi request reprint Helicobacter pylori induces matrix metalloproteinase-9 through activation of nuclear factor kappaB
    Naoki Mori
    Department of Virology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Gastroenterology 124:983-92. 2003
  8. ncbi request reprint Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells
    Naoki Mori
    Department of Preventive Medicine and AIDS Research, Institute of Tropical Medicine, Nagasaki University, Japan
    Blood 100:1828-34. 2002
  9. ncbi request reprint Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Int J Cancer 118:765-72. 2006
  10. ncbi request reprint Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway
    Chie Ishikawa
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of Ryukyus, Nishihara, Japan
    Br J Haematol 136:424-32. 2007

Detail Information

Publications94

  1. pmc Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-kappaB activation
    Masaya Higuchi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Retrovirology 2:29. 2005
    ..The aim of this study was to identify the molecules responsible for the constitutive activation of NF-kappaB in ATL cells using a retroviral functional cloning strategy...
  2. ncbi request reprint Cell signaling modifiers for molecular targeted therapy in ATLL
    Naoki Mori
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Front Biosci (Landmark Ed) 14:1479-89. 2009
    ..The potential translation of such strategies into effective therapies for patients with ATLL may improve the poor outcome associated with this neoplasia...
  3. ncbi request reprint Elevated expression of CCL5/RANTES in adult T-cell leukemia cells: possible transactivation of the CCL5 gene by human T-cell leukemia virus type I tax
    Naoki Mori
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Int J Cancer 111:548-57. 2004
    ..Aberrant expression of CCL5 by HTLV-I-infected T cells may impact on the pathophysiology of HTLV-I-associated diseases...
  4. pmc Apoptosis induced by the histone deacetylase inhibitor FR901228 in human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells
    Naoki Mori
    Division of Molecular Virology and Oncology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0215, Japan
    J Virol 78:4582-90. 2004
    ..Our results indicated that FR901228 could induce apoptosis of these cells and suppress the expression of NF-kappaB and AP-1 and suggest that FR901228 could be therapeutically effective in ATL...
  5. pmc Helicobacter pylori induces RANTES through activation of NF-kappa B
    Naoki Mori
    Department of Virology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Infect Immun 71:3748-56. 2003
    ..pylori induced NF-kappa B activation through an intracellular signaling pathway that involved IKK and NIK, leading to RANTES gene transcription. RANTES induction by H. pylori may play an important role in gastric inflammation...
  6. ncbi request reprint Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB
    Naoki Mori
    Department of Virology, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Int J Cancer 105:661-8. 2003
    ..These results enhance our understanding of the molecular mechanisms of viral pathogenesis in EBV-associated malignancies...
  7. ncbi request reprint Helicobacter pylori induces matrix metalloproteinase-9 through activation of nuclear factor kappaB
    Naoki Mori
    Department of Virology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Gastroenterology 124:983-92. 2003
    ..The aim of this study was to analyze the molecular mechanism responsible for Helicobacter pylori-mediated MMP expression...
  8. ncbi request reprint Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells
    Naoki Mori
    Department of Preventive Medicine and AIDS Research, Institute of Tropical Medicine, Nagasaki University, Japan
    Blood 100:1828-34. 2002
    ..Our results indicate that NF-kappaB plays a crucial role in the pathogenesis and survival of HTLV-I-infected leukemic cells and that it is a suitable target for the prevention and treatment of ATL...
  9. ncbi request reprint Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Int J Cancer 118:765-72. 2006
    ..Curcumin inhibited the growth of HTLV-I-infected T-cell tumors implanted subcutaneously in SCID mice. Our results indicate that curcumin has tumor-suppressive activity against ATL...
  10. ncbi request reprint Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway
    Chie Ishikawa
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of Ryukyus, Nishihara, Japan
    Br J Haematol 136:424-32. 2007
    ..These findings suggest that incadronate could be potentially useful for the treatment of ATL...
  11. pmc NF-kappaB activation by Helicobacter pylori requires Akt-mediated phosphorylation of p65
    Eriko Takeshima
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    BMC Microbiol 9:36. 2009
    ..We examined whether H. pylori activates Akt in gastric epithelial cells, the role of cag PAI in this process and the role of Akt in regulating H. pylori-induced NF-kappaB activation...
  12. ncbi request reprint NIK-333 inhibits growth of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells in association with blockade of nuclear factor-kappaB signal pathway
    Taeko Okudaira
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Mol Cancer Ther 5:704-12. 2006
    ..c. in severe combined immunodeficient mice. Our results indicate that NIK-333 is a potentially useful therapeutic agent for patients with ATL...
  13. pmc Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules
    Hiromitsu Teruya
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Retrovirology 5:86. 2008
    ..However, little is known about induction of these genes by HTLV-I infection in lung epithelial cells...
  14. ncbi request reprint Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Leuk Res 30:313-21. 2006
    ..Inhibition of AP-1 activity by curcumin may be one of the mechanisms responsible for the anti-ATL effect of curcumin. We propose that curcumin is a potentially promising compound for the treatment of ATL...
  15. doi request reprint Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Int J Cancer 124:2607-15. 2009
    ..These findings highlight the critical role of Aurora A in HTLV-1-infected T cells, making this molecule a potentially suitable target for future therapies for ATL...
  16. ncbi request reprint A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells
    Shoko Makishi
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Br J Haematol 142:583-94. 2008
    ..hG9NC(null) inhibited the expression of JunD, resulting in the suppression of AP-1. Our results suggest that hG9NC(null) is a potentially suitable agent for the management of BL and HL...
  17. pmc Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara 903 0215, Japan
    Biochem J 406:317-23. 2007
    ..As HIF-1 plays a major role in tumour progression, it may represent a molecular target for the development of novel ATL therapeutics...
  18. ncbi request reprint Fucoidan extracted from Cladosiphon okamuranus Tokida induces apoptosis of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells
    Kaori Haneji
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Nutr Cancer 52:189-201. 2005
    ..Our results indicate that fucoidan is a potentially useful therapeutic agent for patients with ATL...
  19. pmc Helicobacter pylori-induced interleukin-12 p40 expression
    Eriko Takeshima
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Infect Immun 77:1337-48. 2009
    ..Hsp90 is also a crucial regulator of H. pylori-induced IL-12 p40 expression. In addition to the cag PAI, VacA might be relevant in the induction of IL-12 expression and a Th1-polarized response only in T cells...
  20. pmc Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells
    Reika Takamatsu
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    BMC Microbiol 10:1. 2010
    ..pneumophila to infect and stimulate the production of interleukin-8 (IL-8) in T cells. The objective of this study was to assess whether L. pneumophila interferes with the immune system by interacting and infecting T cells...
  21. pmc Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells
    Hiromitsu Teruya
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    BMC Microbiol 7:102. 2007
    ..We investigated the effect of L. pneumophila on the expression of interleukin-8 (IL-8) in human A549 alveolar and NCI-H292 tracheal epithelial cell lines...
  22. ncbi request reprint A modified version of galectin-9 suppresses cell growth and induces apoptosis of human T-cell leukemia virus type I-infected T-cell lines
    Taeko Okudaira
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Int J Cancer 120:2251-61. 2007
    ..Our results suggest that hG9NC(null) could be a suitable agent for the management of ATL...
  23. doi request reprint Overexpression of caveolin-1 in adult T-cell leukemia
    Shigeki Sawada
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Blood 115:2220-30. 2010
    ..Thus, we describe a new function for Tax, repression of TGF-beta signaling through caveolin-1 expression, which may play a critical role in ATL leukemogenesis...
  24. doi request reprint Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol
    Chie Ishikawa
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Int J Cancer 123:2702-12. 2008
    ..Our preclinical data suggest that fucoxanthin and fucoxanthinol could be potentially useful therapeutic agents for patients with ATL...
  25. pmc Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Retrovirology 3:22. 2006
    ..Our purposes in this study were to determine whether activation of Jak-Stat pathway is responsible for the proliferation and survival of ATL cells, and to explore mechanisms by which inhibition of Jak-Stat pathway kills ATL cells...
  26. pmc Helicobacter pylori induces CCL20 expression
    Koh Tomimori
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Infect Immun 75:5223-32. 2007
    ..pylori-induced CCL20 expression, presumably contributing to the immune response in H. pylori...
  27. doi request reprint Inhibition of Akt/GSK3beta signalling pathway by Legionella pneumophila is involved in induction of T-cell apoptosis
    Reika Takamatsu
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Biochem J 427:57-67. 2010
    ..In conclusion, L. pneumophila induces mitochondria-mediated T-cell apoptosis through inhibition of the Akt/GSK3beta signalling pathway...
  28. pmc Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol
    Yoshiaki Machijima
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Retrovirology 6:7. 2009
    ..The aim of this study was to determine the potential anti-ATLL effects of I3C both in vitro and in vivo...
  29. ncbi request reprint Inhibition of heat shock protein-90 modulates multiple functions required for survival of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells
    Hirochika Kawakami
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Int J Cancer 120:1811-20. 2007
    ..Collectively, our results indicate that 17-AAG suppresses ATL cell survival through, at least in part, destabilization of several client proteins and suggest that 17-AAG is a potentially useful chemotherapeutic agent for ATL...
  30. doi request reprint Anti-adult T-cell leukemia effects of a novel synthetic retinoid, Am80 (Tamibarotene)
    Tetsuro Nakazato
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Cancer Sci 99:2286-94. 2008
    ..These findings demonstrate that Am80 is a potential inhibitor of NF-kappaB and AP-1, and is a potentially useful therapeutic agent against ATL...
  31. ncbi request reprint Transactivation of CCL20 gene by Epstein-Barr virus latent membrane protein 1
    Taeko Okudaira
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Br J Haematol 132:293-302. 2006
    ..The requirement for the NF-kappaB-binding site in the CCL20 promoter in LMP-1 responsiveness was established. Our results indicate that activation of the NF-kappaB pathway by LMP-1 is required for the activation of CCL20 expression...
  32. doi request reprint Aurora kinase inhibitor AZD1152 negatively affects the growth and survival of HTLV-1-infected T lymphocytes in vitro
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Int J Cancer 127:1584-94. 2010
    ..Our results suggest that specific inhibition of Aurora B kinase is a potentially useful therapeutic strategy in the treatment of ATL and that further in vivo exploration is warranted...
  33. ncbi request reprint Activation of cyclin D1 and D2 promoters by human T-cell leukemia virus type I tax protein is associated with IL-2-independent growth of T cells
    Naoki Mori
    Department of Preventive Medicine and AIDS Research, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    Int J Cancer 99:378-85. 2002
    ..Our findings link HTLV-I infection to changes in cellular D-type cyclin gene expression, transformation of T cells and subsequent development of T-cell leukemia...
  34. ncbi request reprint Transactivation of the CCL5/RANTES gene by Epstein-Barr virus latent membrane protein 1
    Jun Nosuke Uchihara
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Int J Cancer 114:747-55. 2005
    ..These results indicate that the activation of the NF-kappaB pathway by LMP-1 is required for the activation of CCL5 expression...
  35. ncbi request reprint Curcumin targets Akt cell survival signaling pathway in HTLV-I-infected T-cell lines
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Cancer Sci 97:322-7. 2006
    ..We propose that Akt-targeting agents could be useful for the treatment of ATL. In this regard, curcumin is a potentially promising compound for the treatment of ATL...
  36. doi request reprint Anticancer effects of marine carotenoids, fucoxanthin and its deacetylated product, fucoxanthinol, on osteosarcoma
    Takayoshi Rokkaku
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0215, Japan
    Int J Oncol 43:1176-86. 2013
    ..Our findings provide a rationale for clinical evaluation of these novel agents in osteosarcoma...
  37. ncbi request reprint Transcriptional activation of survivin through the NF-kappaB pathway by human T-cell leukemia virus type I tax
    Hirochika Kawakami
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Int J Cancer 115:967-74. 2005
    ..Our findings suggest that activated NF-kappaB signaling contributes directly to malignant progression of ATL by preventing apoptosis, acting through the prosurvival protein survivin...
  38. doi request reprint Helicobacter pylori VacA activates NF-kappaB in T cells via the classical but not alternative pathway
    Eriko Takeshima
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Helicobacter 14:271-9. 2009
    ..VacA has also immunosuppressive effects, inhibiting interleukin (IL)-2 secretion by interference with the T cell receptor/IL-2 signaling pathway. This study investigated the effect of VacA on gene expression of T cells...
  39. pmc Human T-cell leukemia virus type 1 tax dysregulates beta-catenin signaling
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    J Virol 80:10497-505. 2006
    ..These results indicate that Tax activates beta-catenin through the Akt signaling pathway. Our findings suggest that activation of beta-catenin by Tax may be important in the transformation of T cells by HTLV-1 infection...
  40. ncbi request reprint Protein phosphatase 2A as a potential target for treatment of adult T cell leukemia
    Naoki Mori
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Curr Cancer Drug Targets 13:829-42. 2013
    ..These results suggest that PP2A is a potentially useful target in the treatment of ATL...
  41. pmc Dengue virus-induced apoptosis in hepatic cells is partly mediated by Apo2 ligand/tumour necrosis factor-related apoptosis-inducing ligand
    Takehiro Matsuda
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Uehara 207, Nishihara, Okinawa 903 0215, Japan
    J Gen Virol 86:1055-65. 2005
    ..It was proposed that DEN infection promotes apoptosis partly through the induction of Apo2L/TRAIL expression...
  42. ncbi request reprint Potential mechanism of resistance to TRAIL-induced apoptosis in Burkitt's lymphoma
    Senji Tafuku
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Eur J Haematol 76:64-74. 2006
    ....
  43. pmc Resistance to Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis and constitutive expression of Apo2L/TRAIL in human T-cell leukemia virus type 1-infected T-cell lines
    Takehiro Matsuda
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    J Virol 79:1367-78. 2005
    ....
  44. ncbi request reprint Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir
    M Zahidunnabi Dewan
    Department of Molecular Virology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Blood 107:716-24. 2006
    ..These results would provide a new concept and novel platform for new drug development of leukemia and solid cancer as well...
  45. doi request reprint Fucoxanthin and its deacetylated product, fucoxanthinol, induce apoptosis of primary effusion lymphomas
    Kei Yamamoto
    Department of Microbiology and Oncology, University of the Ryukyus, Nishihara, Okinawa, Japan
    Cancer Lett 300:225-34. 2011
    ..In animal studies, treatment with FX reduced the growth of PEL-cell tumors. The results provide the rationale for future clinical use of FX and FXOH for the treatment of PEL...
  46. doi request reprint Effects of AZD1152, a selective Aurora B kinase inhibitor, on Burkitt's and Hodgkin's lymphomas
    Naoki Mori
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Biochem Pharmacol 81:1106-15. 2011
    ..AZD1152 had anti-tumour effects in this murine xenograft model. There preclinical data suggest that the inhibition of Aurora B kinase is a potentially useful therapeutic strategy in BL and HL...
  47. doi request reprint CD69 overexpression by human T-cell leukemia virus type 1 Tax transactivation
    Chie Ishikawa
    Department of Microbiology and Oncology, University of the Ryukyus, Okinawa, Japan
    Biochim Biophys Acta 1833:1542-52. 2013
    ..We conclude that CD69 is a Tax-regulated gene, and its regulation by Tax may play a role in cellular activation and HTLV-1-induced disease pathogenesis...
  48. doi request reprint Anti-neoplastic effects of fucoxanthin and its deacetylated product, fucoxanthinol, on Burkitt's and Hodgkin's lymphoma cells
    Senji Tafuku
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0215, Japan
    Oncol Rep 28:1512-8. 2012
    ..The results indicated that FX and FXOH are potentially useful therapeutic agents in B-cell malignancies characterized by aberrant regulation of NF-κB...
  49. doi request reprint Epstein-Barr virus-encoded latent membrane protein 1 activates beta-catenin signaling in B lymphocytes
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    Cancer Sci 100:807-12. 2009
    ..Activation of the beta-catenin pathway by Epstein-Barr virus may contribute to the lymphoproliferation characteristic of Epstein-Barr virus-infected B-cells...
  50. ncbi request reprint Human T-cell leukemia virus type I Tax transactivates the matrix metalloproteinase-9 gene: potential role in mediating adult T-cell leukemia invasiveness
    Naoki Mori
    Departments of Preventive Medicine and AIDS Research, and Pathology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    Blood 99:1341-9. 2002
    ..In addition, plasma levels of MMP-9 correlated with organ involvement in ATL patients. Together these data suggest that overexpression of MMP-9 in HTLV-I- infected cells may be in part responsible for the invasiveness of ATL cells...
  51. pmc Hippuristanol reduces the viability of primary effusion lymphoma cells both in vitro and in vivo
    Chie Ishikawa
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Mar Drugs 11:3410-24. 2013
    ..The results of the in vitro and in vivo experiments underline the potential usefulness of hippuristanol in the treatment of PEL. ..
  52. ncbi request reprint Human T cell leukemia virus type I-infected patients with Hashimoto's thyroiditis and Graves' disease
    Takehiro Matsuda
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0215, Japan
    J Clin Endocrinol Metab 90:5704-10. 2005
    ....
  53. pmc Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone
    Makoto Furugen
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara Town, Okinawa 903 0215, Japan
    Respir Res 9:39. 2008
    ..In this study, we investigated the precise mechanism by which A549 alveolar epithelial cells induced by L. pneumophila undergo apoptosis. We also studied the effect of methyl prednisolone on apoptosis in these cells...
  54. doi request reprint Anti-adult T-cell leukemia effects of Bidens pilosa
    Shinji Nakama
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Int J Oncol 38:1163-73. 2011
    ..In animals harboring tumors of HTLV-1-infected T-cell origin, treatment with B. pilosa extracts suppressed tumor growth. Our results suggest that B. pilosa is a potentially useful medicinal plant for treatment of ATL...
  55. pmc Antitumor activity and macrophage nitric oxide producing action of medicinal herb, Crassocephalum crepidioides
    Koh Tomimori
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0215, Japan
    BMC Complement Altern Med 12:78. 2012
    ..The aim of this study was to determine the in vitro and in vivo antitumor activities of C. crepidioides on murine Sarcoma 180 (S-180) and related molecular mechanisms...
  56. doi request reprint Interleukin-1 alpha produced by human T-cell leukaemia virus type I-infected T cells induces intercellular adhesion molecule-1 expression on lung epithelial cells
    Yuko Nakayama
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    J Med Microbiol 60:1750-61. 2011
    ..These results suggest that IL-1α produced by HTLV-I-infected Tax(+) T cells is crucial for ICAM-1 expression in lung epithelial cells and subsequent adhesion of lymphocytes in HTLV-I-related pulmonary diseases...
  57. ncbi request reprint Transactivation of the ICAM-1 gene by CD30 in Hodgkin's lymphoma
    Jun Nosuke Uchihara
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Int J Cancer 118:1098-107. 2006
    ....
  58. doi request reprint Anti-tumor activity of fucoidan is mediated by nitric oxide released from macrophages
    Kaori Takeda
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Int J Oncol 40:251-60. 2012
    ....
  59. ncbi request reprint The Kaposi's sarcoma-associated herpesvirus K-bZIP protein represses transforming growth factor beta signaling through interaction with CREB-binding protein
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara 903 0215, Japan
    Oncogene 23:8272-81. 2004
    ..We propose a possibility that K-bZIP may contribute to oncogenesis through its ability to promote cell survival by repressing TGF-beta signaling...
  60. doi request reprint This article has been retracted: Curcumin targets Akt cell survival signaling pathway in HTLV-I-infected T-cell lines
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus Division of Child Health and Welfare, Faculty of Medicine, University of the Ryukyus Division of Endocrinology and Metabolism, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215 and Department of Internal Medicine, Naha Prefectural Hospital, 1 3 1 Yogi, Naha, Okinawa 902 8531, Japan
    Cancer Sci 102:498. 2011
    ..Takehiro Matsuda, Hirochika Kawakami, Jun-nosuke Uchihara, Taeko Okudaira, Masato Masuda, Kazuiku Ohshiro and Naoki Mori. Curcumin targets Akt cell survival signaling pathway in HTLV-I-infected T-cell lines, Cancer Science 2006; 97: ..
  61. doi request reprint This article has been retracted: Curcumin targets Akt cell survival signaling pathway in HTLV-I-infected T-cell lines
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus Division of Child Health and Welfare, Faculty of Medicine, University of the Ryukyus Division of Endocrinology and Metabolism, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215 and Department of Internal Medicine, Naha Prefectural Hospital, 1 3 1 Yogi, Naha, Okinawa 902 8531, Japan
    Cancer Sci 102:499. 2011
    ..Mariko Tomita, Jun-nosuke Uchihara, Naoya Taira, Masato Masuda, Yuetsu Tanaka, Kazuiku Ohshiro, Nobuyuki Takasu, Naoki Mori. Anti-adult T-cell leukemia effects of a novel synthetic retinoid, Am80 (Tamibarotene), Cancer Science 2008; 99: ..
  62. doi request reprint Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling
    Sawako Nakachi
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Biochim Biophys Acta 1813:731-41. 2011
    ..These results suggest that the induction of MMP-7 by Tax is regulated by JunD and that MMP-7 could facilitate visceral invasion in ATL. This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
  63. doi request reprint Activation of AID by human T-cell leukemia virus Tax oncoprotein and the possible role of its constitutive expression in ATL genesis
    Chie Ishikawa
    Department of Microbiology and Oncology, University of the Ryukyus, Nishihara, Okinawa, Japan
    Carcinogenesis 32:110-9. 2011
    ....
  64. doi request reprint Phosphorylated c-Jun and Fra-1 induce matrix metalloproteinase-1 and thereby regulate invasion activity of 143B osteosarcoma cells
    Ryuichiro Kimura
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Biochim Biophys Acta 1813:1543-53. 2011
    ..These data suggest that MMP-1 plays a central role in osteosarcoma invasion. Accordingly, MMP-1 might be a biomarker and therapeutic target for invasive osteosarcomas and pulmonary metastases...
  65. ncbi request reprint Aurora A selective inhibitor MLN8237 suppresses the growth and survival of HTLV-1-infected T-cells in vitro
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    Cancer Sci 101:1204-11. 2010
    ..Our results suggest that specific inhibition of Aurora A kinase is a potentially useful therapeutic strategy in the treatment of adult T-cell leukemia and that further in vivo exploration is warranted...
  66. doi request reprint Downregulation of citrin, a mitochondrial AGC, is associated with apoptosis of hepatocytes
    Shigeki Sawada
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 2 07 Uehara, Nishihara, Okinawa 903 0215, Japan
    Biochem Biophys Res Commun 364:937-44. 2007
    ..Our results indicated that citrin downregulation induces apoptosis of hepatocytes through the mitochondrial death pathway, highlighting the importance of citrin in survival of hepatocytes and maintenance of liver function...
  67. ncbi request reprint Matrix metalloproteinase-9 and vascular endothelial growth factor: a possible link in adult T-cell leukaemia cell invasion
    Toshihisa Hayashibara
    Department of Biochemistry, Molecular Medicine Unit, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki University, Nagasaki, Japan
    Br J Haematol 116:94-102. 2002
    ..Furthermore, we showed that both increased plasma MMP-9 and VEGF were significantly related to high ATL cell infiltration. All these findings strongly suggest that MMP-9 and VEGF act co-operatively in the process of ATL cell invasion...
  68. pmc Induction of CD69 expression by cagPAI-positive Helicobacter pylori infection
    Naoki Mori
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0215, Japan
    World J Gastroenterol 17:3691-9. 2011
    ..To investigate and elucidate the molecular mechanism that regulates inducible expression of CD69 by Helicobacter pylori (H. pylori) infection...
  69. ncbi request reprint [Helicobacter pylori induces matrix metalloproteinase expression]
    Naoki Mori
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus
    Nihon Rinsho 63:138-45. 2005
  70. pmc Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells
    Noriko Hironaka
    Department of Molecular Virology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Neoplasia 6:266-78. 2004
    ..Further elucidation of this cellular mechanism should contribute to establishing a rationale for treatment of ATL...
  71. ncbi request reprint Interferon-gamma reverses the evasion of Birc1e/Naip5 gene mediated murine macrophage immunity by Legionella pneumophila mutant lacking flagellin
    Morikazu Akamine
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    Microbiol Immunol 51:279-87. 2007
    ..These findings suggested that IFN-gamma activated macrophages to restrict the intracellular growth of the L. pneumophila flaA mutant by a NO independent pathway...
  72. ncbi request reprint Recent change of the antigenicity and genotype of Japanese encephalitis viruses distributed on Okinawa Island, Japan
    Mika Saito
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    Am J Trop Med Hyg 77:737-46. 2007
    ..These results strongly suggest that the genotype and antigenicity of JEV on Okinawa Island have changed significantly over the past decade...
  73. ncbi request reprint [Molecular targeted therapy in adult T-cell leukemia/lymphoma]
    Naoki Mori
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus
    Nihon Rinsho 65:709-18. 2007
  74. ncbi request reprint [Oncogenic mechanisms of KSHV]
    Mariko Tomita
    Division of Molecular Virology and Oncology, Department of Microbiology, Graduate School of Medicine, University of the Ryukyus
    Nihon Rinsho 64:603-8. 2006
  75. pmc Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/gammac(null) mice: suppression by an inhibitor against NF-kappaB
    M Zahidunnabi Dewan
    Department of Molecular Virology, Bio Response, Graduate School, Tokyo Medical and Dental University, Japan
    J Virol 77:5286-94. 2003
    ..This in vivo model of ATL could provide a novel system for use in clarifying the mechanism of growth of HTLV-1-infected cells as well as for the development of new drugs against ATL...
  76. ncbi request reprint Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3
    Minako Ohashi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Virology 320:52-62. 2004
    ..Our results suggest that the interaction of Tax1 and MAGI-3 alters their respective biological activities, which may play a role in transformation by Tax1 as well as in the pathogenesis of HTLV-1-associated diseases...
  77. ncbi request reprint Potential role of natural killer cells in controlling growth and infiltration of AIDS-associated primary effusion lymphoma cells
    Md Zahidunnabi Dewan
    Department of Molecular Virology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Cancer Sci 97:1381-7. 2006
    ..The rapid and efficient engraftment of PEL cells in NOG mice also suggests that this new animal model could provide a unique opportunity to understand and investigate the mechanism of pathogenesis and malignant cell growth...
  78. ncbi request reprint Expression of the c-Met proto-oncogene and its possible involvement in liver invasion in adult T-cell leukemia
    Yoshitaka Imaizumi
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Sciences, Nagasaki 852 8523, Japan
    Clin Cancer Res 9:181-7. 2003
    ..Taken together, these data suggest for the first time that c-Met is involved in the liver invasive phenotype of ATL...
  79. ncbi request reprint Possible involvement of aryl hydrocarbon receptor (AhR) in adult T-cell leukemia (ATL) leukemogenesis: constitutive activation of AhR in ATL
    Toshihisa Hayashibara
    Department of Biochemistry, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1 12 4, Japan
    Biochem Biophys Res Commun 300:128-34. 2003
    ..To our best knowledge, this is the first report to show the lymphoid malignancy having constitutive activation of AhR. A possible link between increased AhR expression and leukemogenesis in ATL is discussed...
  80. ncbi request reprint A novel mutation of the OPA1 gene in a Japanese family with optic atrophy type 1
    Satoko Shimizu
    Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan
    Jpn J Ophthalmol 46:336-40. 2002
    ..To report a novel mutation of the OPA1 gene in a Japanese family with optic atrophy type 1 (OPA1) and to describe the clinical features of this family...
  81. ncbi request reprint Multiple gammac-receptor expression in adult T-cell leukemia
    Hirofumi Baba
    Department of Laboratory Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Eur J Haematol 68:362-9. 2002
    ..Overlapping and switching of cytokine receptors supported the idea that ATL cells can rapidly select the appropriate gammac-receptor according to conditions...
  82. ncbi request reprint [HTLV-1: multistep leukemogenesis of adult T-cell leukemia]
    Masahiro Fujii
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences
    Uirusu 52:103-8. 2002
  83. ncbi request reprint Lack of nucleophosmin mutation in patients with myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities
    Masayuki Shiseki
    Department of Hematology, Tokyo Women s Medical University, Tokyo, Japan
    Leuk Lymphoma 48:2141-4. 2007
    ..Therefore, we carried out a mutational analysis on the NPM1 gene exon 12. NPM1 mutations were not detected in the 28 patients with MDS and AML with chromosome 5 abnormalities...
  84. ncbi request reprint Genealogical use of chloroplast DNA variation for intraspecific studies of Aegilops tauschii Coss
    Yoshihiro Matsuoka
    Fukui Prefectural University, Matsuoka cho, Yoshida gun, Japan
    Theor Appl Genet 111:265-71. 2005
    ..These findings show that the chloroplast genome harbors evolutionary variations informative for intraspecific studies of Ae. tauschii and can be analyzed by genealogical approaches...
  85. ncbi request reprint [Mass screening for prostate cancer in Ikeda City Osaka]
    Koichi Tsutahar
    The Department of Urology, Ikeda Municipal Hospital
    Nihon Hinyokika Gakkai Zasshi 97:791-5. 2006
    ..Screening with prostate specific antigen (PSA) to detect prostate cancer was started in Ikeda City Osaka from 2003 as part of the city's health program. We evaluated the first year's result...
  86. ncbi request reprint [Molecular mechanisms of anti-apoptotic signaling by HTLV-1]
    Naoki Mori
    Rinsho Ketsueki 49:215-24. 2008
  87. doi request reprint Induction of allergic contact dermatitis by astigmatid mite-derived monoterpene, alpha-acaridial
    Toshio Sasai
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto 606 8502, Japan
    Biochem Biophys Res Commun 375:336-40. 2008
    ..Our study now emphasizes that small lipidic compounds released from mites comprise a new class of mite allergens, and therefore, is of significant medical implications...
  88. ncbi request reprint Truncation mutation in HRG4 (UNC119) leads to mitochondrial ANT-1-mediated photoreceptor synaptic and retinal degeneration by apoptosis
    Naoki Mori
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 47:1281-92. 2006
    ....
  89. ncbi request reprint Chloroplast and nuclear microsatellite analysis of Aegilops cylindrica
    Harish T Gandhi
    Department of Crop and Soil Science, Oregon State University, 107 Crop Science Building, Corvallis, OR 97331 3002, USA
    Theor Appl Genet 111:561-72. 2005
    ..cylindrica were closely related to, and were probably derived from, the tauschii gene pool of Ae. tauschii. A determination of the likely source of the C genome and the C-type plastome in Ae. cylindrica was not possible...
  90. ncbi request reprint Chloroplast and nuclear DNA variation in common wheat: insight into the origin and evolution of common wheat
    Shujiro Hirosawa
    Laboratory of Plant Genetics, Department of Biological and Environmental Science, Faculty of Agriculture, Kobe University, Nada Ku, Kobe, 657 8501, Japan
    Genes Genet Syst 79:271-82. 2004
    ..Taken together, our data indicate the existence of at least two maternal lineages in common wheat and support the hypothesis that European spela wheat originated in Europe separately from other groups of common wheat...
  91. ncbi request reprint Heavily melanotic perivascular epithelioid clear cell tumor of the kidney
    Shiro Adachi
    Department of Pathology and Laboratory Medicine, The City Hospital of Ikeda, Osaka, Japan
    Pathol Int 54:261-5. 2004
    ..Immunohistochemical examinations and the presence of cytoplasmic melanin can help the differentiation...
  92. ncbi request reprint Gene transduction efficiency and maturation status in mouse bone marrow-derived dendritic cells infected with conventional or RGD fiber-mutant adenovirus vectors
    Naoki Okada
    Department of Biopharmaceutics, Kyoto Pharmaceutical University, 5 Nakauchi cho, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Cancer Gene Ther 10:421-31. 2003
    ..AdRGD-infection caused greater induction of maturation than conventional Ad-infection, irrespective of the type of transgene inserted...
  93. ncbi request reprint A novel mutation in the OPA1 gene in a Japanese patient with optic atrophy
    Satoko Shimizu
    Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan
    Am J Ophthalmol 135:256-7. 2003
    ..To report a novel mutation of the OPA1 gene in a Japanese patient with optic atrophy and to describe the clinical features of the patient...
  94. pmc Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function
    Yasutsugu Ishiba
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 N W, 10th Avenue, Miami, FL 33136, USA
    Exp Eye Res 84:473-85. 2007
    ..These models will be useful in elucidating the functions of HRG4/MRG4 and the mechanism of slow retinal degeneration...