Katsuyoshi Mizukami

Summary

Affiliation: University of Tsukuba
Country: Japan

Publications

  1. ncbi request reprint Immunohistochemical localization of gamma-aminobutyric acid(B) receptor in the hippocampus of subjects with schizophrenia
    K Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba City, Ibaraki, Japan
    Neurosci Lett 283:101-4. 2000
  2. ncbi request reprint Efficacy of milnacipran on the depressive state in patients with Alzheimer's disease
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine University of Tsukuba, Japan, 1 1 1Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1342-6. 2006
  3. doi request reprint Decreased ventilatory response to hypercapnia in dementia with Lewy bodies
    Katsuyoshi Mizukami
    Department of Psychiatry, University of Tsukuba, Tsukuba City, Ibaraki, Japan
    Ann Neurol 65:614-7. 2009
  4. doi request reprint A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Int J Neuropsychopharmacol 12:191-9. 2009
  5. ncbi request reprint Immunohistochemical study of the hnRNP A2 and B1 in the hippocampal formations of brains with Alzheimer's disease
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Neurosci Lett 386:111-5. 2005
  6. ncbi request reprint Therapeutic effects of the selective serotonin noradrenaline reuptake inhibitor milnacipran on depressive symptoms in patients with Alzheimer's disease
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:349-52. 2009
  7. pmc An immunohistochemical study of the serotonin 1A receptor in the hippocampus of subjects with Alzheimer's disease
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Neuropathology 31:503-9. 2011
  8. ncbi request reprint Immunohistochemical localization of GABAB receptor in the entorhinal cortex and inferior temporal cortex of schizophrenic brain
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukaba, Ibaraki, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 26:393-6. 2002
  9. ncbi request reprint Alterations of ubiquitin immunoreactivity in the hippocampal formation after perforant pathway lesion
    K Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Acta Neuropathol 103:453-7. 2002
  10. ncbi request reprint Immunohistochemical study of hnRNP B1 in the postmortem temporal cortices of patients with Alzheimer's disease
    Masanori Ishikawa
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Neurosci Res 50:481-4. 2004

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Immunohistochemical localization of gamma-aminobutyric acid(B) receptor in the hippocampus of subjects with schizophrenia
    K Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba City, Ibaraki, Japan
    Neurosci Lett 283:101-4. 2000
    ....
  2. ncbi request reprint Efficacy of milnacipran on the depressive state in patients with Alzheimer's disease
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine University of Tsukuba, Japan, 1 1 1Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1342-6. 2006
    ..In addition, the treatment had no negative effects on cognitive function of the patients. Our study results suggest that milnacipran is a promising medicine for depressive state in AD patients...
  3. doi request reprint Decreased ventilatory response to hypercapnia in dementia with Lewy bodies
    Katsuyoshi Mizukami
    Department of Psychiatry, University of Tsukuba, Tsukuba City, Ibaraki, Japan
    Ann Neurol 65:614-7. 2009
    ..Ventilatory response to hypercapnia as a marker of respiratory autonomic function is a promising diagnostic tool for DLB...
  4. doi request reprint A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Int J Neuropsychopharmacol 12:191-9. 2009
    ..TJ-54 did not show any effect on either cognitive function or ADL. No serious adverse reactions were observed. The present study suggests that TJ-54 is an effective and well-tolerated treatment for patients with BPSD...
  5. ncbi request reprint Immunohistochemical study of the hnRNP A2 and B1 in the hippocampal formations of brains with Alzheimer's disease
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Neurosci Lett 386:111-5. 2005
    ..Our study suggests that hnRNP A2 and B1 display different responses in the AD hippocampus, and further suggests that the post-transcriptional regulation is disturbed in neurons of the AD hippocampus...
  6. ncbi request reprint Therapeutic effects of the selective serotonin noradrenaline reuptake inhibitor milnacipran on depressive symptoms in patients with Alzheimer's disease
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:349-52. 2009
    ..Our study also suggests that milnacipran is promising to treat a broad range of depressive symptoms in AD-MD patients...
  7. pmc An immunohistochemical study of the serotonin 1A receptor in the hippocampus of subjects with Alzheimer's disease
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Neuropathology 31:503-9. 2011
    ..Thus, the utility of PET imaging using a 5-HT1A-specific radiolabeled probe as a marker of hippocampal neuronal loss may be limited to the CA1 field in advanced stage AD cases...
  8. ncbi request reprint Immunohistochemical localization of GABAB receptor in the entorhinal cortex and inferior temporal cortex of schizophrenic brain
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukaba, Ibaraki, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 26:393-6. 2002
    ....
  9. ncbi request reprint Alterations of ubiquitin immunoreactivity in the hippocampal formation after perforant pathway lesion
    K Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Acta Neuropathol 103:453-7. 2002
    ..These data suggest that deafferentation of the perforant pathway results in transient reduction in free ubiquitin of the hippocampus, and that the ubiquitin system is involved in hippocampal plasticity following perforant lesions...
  10. ncbi request reprint Immunohistochemical study of hnRNP B1 in the postmortem temporal cortices of patients with Alzheimer's disease
    Masanori Ishikawa
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Neurosci Res 50:481-4. 2004
    ..Our study suggests that hnRNP B1-associated post-transcriptional regulations are preserved in the inferior temporal cortex of Alzheimer's disease...
  11. pmc An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression
    Masahiko Iwakiri
    Department of Psychiatry, Ishizaki Hosipital, Ibaraki machi, Japan
    Neuropathology 29:263-9. 2009
    ..These results suggest that upregulating or preserving GABA(A)gamma1/3 and gamma2 receptors may protect neurons against neurofibrillary pathology in AD...
  12. ncbi request reprint Changes in hippocampal GABABR1 subunit expression in Alzheimer's patients: association with Braak staging
    Masahiko Iwakiri
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, 305 8575, Tsukuba City, Ibaraki, Japan
    Acta Neuropathol 109:467-74. 2005
    ..Thus, changes in hippocampal GBR1 may reflect alterations in the balance between excitatory and inhibitory neurotransmitter systems, which likely contributes to dysfunction of hippocampal circuitry in AD...
  13. doi request reprint Prevalence of depression and depressive symptoms among older Japanese people: comorbidity of mild cognitive impairment and depression
    Shin Hidaka
    Department of Neuropsychiatry, University of Tsukuba, Tsukuba, Japan
    Int J Geriatr Psychiatry 27:271-9. 2012
    ....
  14. ncbi request reprint GABA(A) receptor gamma subunits in the hippocampus of the rat after perforant pathway lesion
    Masahiko Iwakiri
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan
    Neurosci Lett 394:88-91. 2006
    ..Our study suggests that gamma subunits of the GABA(A) receptor in the dentate gyrus display a plastic response to the deafferentation of the perforant pathway...
  15. ncbi request reprint Immunohistochemical and immunoblot analysis of gamma-aminobutyric acid B receptor in the prefrontal cortex of subjects with schizophrenia and bipolar disorder
    Masanori Ishikawa
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba City, Ibaraki 305 8575, Japan
    Neurosci Lett 383:272-7. 2005
    ....
  16. ncbi request reprint Immunohistochemical and immunoblot study of GABA(A) alpha1 and beta2/3 subunits in the prefrontal cortex of subjects with schizophrenia and bipolar disorder
    Masanori Ishikawa
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba City, Ibaraki 305 8575, Japan
    Neurosci Res 50:77-84. 2004
    ..The present study suggests that the expression of these two GABA(A) receptor subunits was altered in subjects with schizophrenia and bipolar disorder, but that the patterns of change differed between those with these two disorders...
  17. doi request reprint Combination of antioxidant supplements improved cognitive function in the elderly
    Fumihiko Yasuno
    Department of Neuropsychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    J Alzheimers Dis 32:895-903. 2012
    ..These synergistically potentiated antioxidant effects of agents contribute to the improvement of cognitive function...
  18. ncbi request reprint Effect of plasma lipids, hypertension and APOE genotype on cognitive decline
    Fumihiko Yasuno
    Department of Neuropsychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    Neurobiol Aging 33:2633-40. 2012
    ..The findings also indicate a synergistic effect of an APOE4 allele and hypertension on the acceleration of cognitive decline...
  19. doi request reprint Dementia and mild cognitive impairment among non-responders to a community survey
    Misa Miyamoto
    Department of Neuropsychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    J Clin Neurosci 16:270-6. 2009
    ..27, 95% CI: 1.37-3.77, p=0.002, aged< or =74). In order to develop a method for the early detection of dementia, we must pay more attention to delayed-or non-responders...
  20. ncbi request reprint Efficacy of perospirone in the management of aggressive behavior associated with dementia
    Shinji Sato
    Department of Psychiatry, Tsukuba Memorial Hospital, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:679-83. 2006
    ..The data suggest that PER is effective in improving aggressive and agitated behavioral symptoms in demented patients and that it is safe to use in elderly patients...
  21. ncbi request reprint Hyperperfusion in primary somatosensory region related to somatic hallucination in the elderly
    Kiyotaka Nemoto
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Psychiatry Clin Neurosci 64:421-5. 2010
    ..The purpose of the present study was to investigate the regional cerebral blood flow (rCBF) of patients with delusional disorder, somatic type (DDST) exhibiting somatic hallucination...
  22. ncbi request reprint Alterations of heterogeneous nuclear RNP A2 and B1 in the hippocampus of the rat after perforant pathway lesion
    Masanori Ishikawa
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, 305 8575 Tsukuba city, Ibaraki, Japan
    Acta Neuropathol 107:144-8. 2004
    ..Our study further suggests that the functions of hnRNPA2 and B1 are different, as each was differentially involved in the plastic response to deafferentation of the perforant pathway...
  23. ncbi request reprint Immunohistochemical and immunoblot analysis of Dopamine and cyclic AMP-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32) in the prefrontal cortex of subjects with schizophrenia and bipolar disorder
    Masanori Ishikawa
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:1177-81. 2007
    ....
  24. doi request reprint ApoE4 is not associated with depression when mild cognitive impairment is considered
    Mayumi Nose
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba City, Japan
    Int J Geriatr Psychiatry 28:155-63. 2013
    ..The aim of the study was to examine the relationship between apolipoprotein E4 allele (ApoE4) and depression among an older Japanese population. Mild cognitive impairment (MCI) was taken into consideration...
  25. ncbi request reprint A preliminary open-label study of 5-HT1A partial agonist tandospirone for behavioural and psychological symptoms associated with dementia
    Shinji Sato
    Department of Psychiatry, Tsukuba Memorial Hospital, Tsukuba, Japan
    Int J Neuropsychopharmacol 10:281-3. 2007
    ..No patients experienced severe adverse effects. The results suggest that tandospirone was effective at improving BPSD symptoms and well-tolerated in elderly demented patients...
  26. doi request reprint Prevalence and causes of early-onset dementia in Japan: a population-based study
    Chiaki Ikejima
    Department of Neuropsychiatry, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
    Stroke 40:2709-14. 2009
    ..Few studies are available that have addressed the prevalence of early-onset dementia (EOD), including early-onset Alzheimer disease and other forms of dementia in Japan...
  27. ncbi request reprint [Respiratory chemosensitivity in dementia with Lewy bodies]
    Toshiaki Homma
    Institute of Clinical Medicine, Division of Respiratory Diseases, University of Tsukuba
    Nihon Kokyuki Gakkai Zasshi 45:297-300. 2007
    ..Respiratory center dysfunction may be related to cardiopulmonary arrest together with unconsciousness, so, patients with DLB should not use drugs affecting the respiratory center...
  28. ncbi request reprint MDR1 gene polymorphism in Japanese patients with schizophrenia and mood disorders including depression
    Wen Qian
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Biol Pharm Bull 29:2446-50. 2006
    ..These findings suggested that predispose to mood disorders, not schizophrenia, was associated with possible alteration of P-gp activities corresponding MDR1 polymorphism at least partly...
  29. ncbi request reprint Alterations of NMDAR1 and NMDAR2a/B immunoreactivity in the hippocampus after perforant pathway lesion
    Masahiko Iwakiri
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Japan
    Neuropathology 22:154-60. 2002
    ..NMDA receptor subunits demonstrate an earlier response to the loss of the perforant pathway fibers than do the AMPA receptor subunits...
  30. ncbi request reprint GABAA receptor gamma subunits in the prefrontal cortex of patients with schizophrenia and bipolar disorder
    Masanori Ishikawa
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Neuroreport 15:1809-12. 2004
    ..The present study suggests that the GABAA receptor gamma subunit is differentially involved in schizophrenia and bipolar disorder, and that the gamma subunit is up-regulated in the prefrontal cortex of subjects with bipolar disorder...
  31. ncbi request reprint Beneficial effects of perospirone on aggressive behavior associated with dementia
    Shinji Sato
    Department of Psychiatry, Tsukuba Memorial Hospital, Tsukuba, Japan
    Psychiatry Clin Neurosci 60:106-9. 2006
    ..This study suggests that perospirone is effective in improving aggressive and agitated behavioral symptoms in demented patients and is safe to use in elderly patients...
  32. doi request reprint Depression associated with dementia with Lewy bodies (DLB) and the effect of somatotherapy
    Sho Takahashi
    Clinical Neuroscience, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Psychogeriatrics 9:56-61. 2009
    ..In this study, we examined the characteristic depressive symptoms of the prestage of DLB and the efficacy and safety of somatotherapy for depression accompanying DLB...
  33. doi request reprint Immunohistochemical analysis of ubiquilin-1 in the human hippocampus: association with neurofibrillary tangle pathology
    Katsuyoshi Mizukami
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tokyo, Japan
    Neuropathology 34:11-8. 2014
    ....
  34. doi request reprint Multicentre population-based dementia prevalence survey in Japan: a preliminary report
    Chiaki Ikejima
    Department of Disaster Psychiatry, University of Tsukuba, Tsukuba, Japan
    Psychogeriatrics 12:120-3. 2012
    ..To verify the upward trend of dementia prevalence and its background factors, we have scheduled surveys for three other urban areas in 2011-2012...
  35. ncbi request reprint Quality of Internet information referring to mental health and mental disorders in Japan
    Kiyotaka Nemoto
    Division of Psychiatry, Tsukuba University Hospital, Tsukuba, Ibaraki, Japan
    Psychiatry Clin Neurosci 61:243-8. 2007
    ..Most of the websites on mental health and mental disorders examined in the present study have scope for improvement. The challenge is to establish a system to evaluate the sites and to motivate each webmaster to improve the sites...
  36. ncbi request reprint Brain magnetic resonance imaging and single photon emission computerized tomography findings in a case of relapsing polychondritis showing cognitive impairment and personality changes
    Miho Ota
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8575, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:347-9. 2005
    ..This is the first study to report on the CNS manifestations of RP with reference to MRI and SPECT findings...
  37. ncbi request reprint [Dementia with Lewy bodies and depressive state]
    Katsuyoshi Mizukami
    Department of Psychiatry, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    Seishin Shinkeigaku Zasshi 114:289-96. 2012
    ..SSRIs and SNRIs are a better choice, with careful monitoring effects and side effects. Modified electro-convulsive therapy (mECT) or transcranial magnetic stimulation therapy (TMS) may be effective for pharmacotherapy-resistant cases...
  38. ncbi request reprint [A psychopathological study on three-dimensional computer graphics (3DCGs): special reference to pictures made by a schizophrenic patient before and after the onset]
    Yuko Ashizawa
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba
    Seishin Shinkeigaku Zasshi 106:1218-31. 2004
    ..However, being absorbed in making 3DCGs could also promote the latent schizophrenic process to the onset...
  39. ncbi request reprint [Progressive subcortical gliosis]
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba
    Nihon Rinsho 62:193-6. 2004
  40. ncbi request reprint A case of delusional disorder, somatic type with remarkable improvement of clinical symptoms and single photon emission computed tomograpy findings following modified electroconvulsive therapy
    Miho Ota
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 27:881-4. 2003
    ....
  41. doi request reprint Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures
    Makoto Takahashi
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi dori 1 757, Niigata 951 8510, Japan
    Schizophr Res 119:210-8. 2010
    ..These results suggest analysis of a blood-based gene expression signature with the supervised classifier, ANNs, might be a diagnostic tool for schizophrenia...
  42. ncbi request reprint A case of neurosyphilis showing a marked improvement of clinical symptoms and cerebral blood flow on single photon emission computed tomography with quantitative penicillin treatment
    Masayuki Ide
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 28:417-20. 2004
    ..Our case study suggests that single photon emission computed tomography (SPECT) is a useful method for evaluating an inflammatory state and for assessing the effect of therapy on neurosyphilis...
  43. ncbi request reprint Plasticity of glutamate and GABAA receptors in the hippocampus of patients with Alzheimer's disease
    David M Armstrong
    Laboratory of Neuronal Vulnerability and Aging, The Lankenau Institute for Medical Research, Jefferson Health System, Wynnewood, Pennsylvania, USA
    Cell Mol Neurobiol 23:491-505. 2003
    ..e., the pathologic hallmarks of AD). Throughout the past several years our laboratory has sought to determine the molecular mechanisms underlying the selective vulnerability of neurons in AD...
  44. ncbi request reprint Association of treatment-resistant schizophrenia with the G2677A/T and C3435T polymorphisms in the ATP-binding cassette subfamily B member 1 gene
    Tetsuya Takao
    Psychiatr Genet 16:47-8. 2006
  45. ncbi request reprint [DARPP-32 in the patients with endogenous psychosis]
    Masanori Ishikawa
    Tsuchiura Kousei Hospital, 3969 Higashiwakamatsu cho, Tsuchiura, Ibaraki 300 0064, Japan
    Brain Nerve 59:1257-63. 2007
    ..We have also found reduced levels of DARPP-32 in the DLPFC of subjects with bipolar disorder. Thus, it is important to elucidate the role of DARPP-32 in the pathophysiology of schizophrenia and bipolar disorder...