Atsushi Miyajima

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming
    Atsushi Miyajima
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan Electronic address
    Cell Stem Cell 14:561-74. 2014
  2. pmc To divide or not to divide: revisiting liver regeneration
    Yuichiro Miyaoka
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Cell Div 8:8. 2013
  3. doi request reprint Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liver
    Mayuko Okabe
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113 0032, Japan
    Development 136:1951-60. 2009
  4. doi request reprint Mouse hepatoblasts at distinct developmental stages are characterized by expression of EpCAM and DLK1: drastic change of EpCAM expression during liver development
    Minoru Tanaka
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    Mech Dev 126:665-76. 2009
  5. doi request reprint Y-box binding protein-1 down-regulates expression of carbamoyl phosphate synthetase-I by suppressing CCAAT enhancer-binding protein-alpha function in mice
    Yen Rong Chen
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Gastroenterology 137:330-40. 2009
  6. doi request reprint Inducible expression of Wnt genes during adult hepatic stem/progenitor cell response
    Tohru Itoh
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    FEBS Lett 583:777-81. 2009
  7. doi request reprint p75 Neurotrophin receptor is a marker for precursors of stellate cells and portal fibroblasts in mouse fetal liver
    Kaori Suzuki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Gastroenterology 135:270-281.e3. 2008
  8. doi request reprint Characterization and functional analyses of hepatic mesothelial cells in mouse liver development
    Izumi Onitsuka
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Gastroenterology 138:1525-35, 1535.e1-6. 2010
  9. pmc FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration
    Hinako M Takase
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Genes Dev 27:169-81. 2013
  10. doi request reprint Development of stabilin2+ endothelial cells from mouse embryonic stem cells by inhibition of TGFbeta/activin signaling
    Hidenori Nonaka
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan Japan Health Sciences Foundation, Chuo Ku, Tokyo, Japan
    Biochem Biophys Res Commun 375:256-60. 2008

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming
    Atsushi Miyajima
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan Electronic address
    Cell Stem Cell 14:561-74. 2014
    ....
  2. pmc To divide or not to divide: revisiting liver regeneration
    Yuichiro Miyaoka
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Cell Div 8:8. 2013
    ..Finally, we describe the revised model and perspectives on liver regeneration research. ..
  3. doi request reprint Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liver
    Mayuko Okabe
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113 0032, Japan
    Development 136:1951-60. 2009
    ....
  4. doi request reprint Mouse hepatoblasts at distinct developmental stages are characterized by expression of EpCAM and DLK1: drastic change of EpCAM expression during liver development
    Minoru Tanaka
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    Mech Dev 126:665-76. 2009
    ..5 liver contain extrahepatic bile duct cells as well as hepatoblasts, while EpCAM(-)DLK1(+) cells contain mesothelial cell precursors. Thus, the expression of EpCAM and DLK1 suggests the developmental pathways of mouse liver progenitors...
  5. doi request reprint Y-box binding protein-1 down-regulates expression of carbamoyl phosphate synthetase-I by suppressing CCAAT enhancer-binding protein-alpha function in mice
    Yen Rong Chen
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Gastroenterology 137:330-40. 2009
    ..Despite expression of C/EBPalpha, CPS1 is not expressed in fetal liver, indicating an additional factor is involved in the regulation of CPS1 expression. The aim of this study was to elucidate the mechanism of CPS1 expression...
  6. doi request reprint Inducible expression of Wnt genes during adult hepatic stem/progenitor cell response
    Tohru Itoh
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    FEBS Lett 583:777-81. 2009
    ..These results together implicate the role of Wnt/beta-catenin signaling in adult hepatic stem/progenitor cell response...
  7. doi request reprint p75 Neurotrophin receptor is a marker for precursors of stellate cells and portal fibroblasts in mouse fetal liver
    Kaori Suzuki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Gastroenterology 135:270-281.e3. 2008
    ..HSCs and PFs play pivotal roles in liver regeneration and fibrosis. However, the roles of mesenchymal cells in fetal liver remain poorly understood. In this study, we aimed to characterize mesenchymal cells in mouse fetal liver...
  8. doi request reprint Characterization and functional analyses of hepatic mesothelial cells in mouse liver development
    Izumi Onitsuka
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Gastroenterology 138:1525-35, 1535.e1-6. 2010
    ..Here we characterized the nature of mouse hepatic mesothelial cells (MCs) and investigated their role in organogenesis...
  9. pmc FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration
    Hinako M Takase
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Genes Dev 27:169-81. 2013
    ..These findings provide new insights into the cellular and molecular basis for LPC regulation and identify FGF7 as a potential therapeutic target for liver diseases...
  10. doi request reprint Development of stabilin2+ endothelial cells from mouse embryonic stem cells by inhibition of TGFbeta/activin signaling
    Hidenori Nonaka
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan Japan Health Sciences Foundation, Chuo Ku, Tokyo, Japan
    Biochem Biophys Res Commun 375:256-60. 2008
    ..Our results reveal that TGFbeta/activin signaling negatively regulates the early events of HSEC differentiation...
  11. doi request reprint Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration
    Yuichiro Miyaoka
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Curr Biol 22:1166-75. 2012
    ..However, ploidy of hepatocytes is known to increase during regeneration, suggesting an unconventional cell cycle. We therefore examine cell cycle of hepatocytes in detail...
  12. doi request reprint Retention in the Golgi apparatus and expression on the cell surface of Cfr/Esl-1/Glg-1/MG-160 are regulated by two distinct mechanisms
    Yuichiro Miyaoka
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Biochem J 440:33-41. 2011
    ..These results suggest that the expression of Cfr in the Golgi apparatus and on the plasma membrane is finely tuned through two distinct mechanisms for exhibiting different functions...
  13. pmc Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis
    Yoshikazu Hirose
    Laboratory of Cell Growth and Differentiation and Laboratory of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 109:4263-8. 2012
    ..These results suggest that blocking Stab2 function prevents tumor metastasis by elevating circulating HA levels. Stab2 may be a potential target in antitumor therapy...
  14. doi request reprint A novel regulatory mechanism for Fgf18 signaling involving cysteine-rich FGF receptor (Cfr) and delta-like protein (Dlk)
    Yuichiro Miyaoka
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Development 137:159-67. 2010
    ..Thus, the Fgf18 signaling pathway seems to be finely tuned by Cfr and Dlk for skeletal development. This study reveals a novel regulatory mechanism for Fgf18 signaling involving Cfr and Dlk...
  15. pmc TROP2 expressed in the trunk of the ureteric duct regulates branching morphogenesis during kidney development
    Yuko Tsukahara
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    PLoS ONE 6:e28607. 2011
    ..These results together suggest that TROP2 modulates the interaction between the cells and matrix and regulates the formation of the ureteric duct by suppressing branching from the trunk during kidney development...
  16. doi request reprint Hedgehog signal activation coordinates proliferation and differentiation of fetal liver progenitor cells
    Yoshikazu Hirose
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    Exp Cell Res 315:2648-57. 2009
    ....
  17. pmc Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25
    Kazunori Senga
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Mol Biol Cell 23:2845-55. 2012
    ..The results reveal a molecular network regulating epithelial lumen formation organized by Grhl2...
  18. ncbi request reprint TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta
    Takahiro Naiki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    J Biol Chem 282:24075-82. 2007
    ..These results suggest that inhibition of Akt activation in combination with degradation of C/EBPbeta is the basis for the strong inhibitory effect of TRB2 on adipogenesis...
  19. doi request reprint Liver stem/progenitor cells: their characteristics and regulatory mechanisms
    Minoru Tanaka
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    J Biochem 149:231-9. 2011
    ..Clonogenic and bipotential cells are also present in the normal adult liver. In this minireview we describe recent studies on liver stem/progenitor cells by focusing on extracellular signals...
  20. ncbi request reprint Liver regeneration by stem/progenitor cells
    Tohru Itoh
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Hepatology 59:1617-26. 2014
    ..Conclusion: Advancing our understanding of the cellular and molecular mechanisms for liver regeneration should provide a basis for developing therapeutic strategies to treat patients with liver disease...
  21. pmc Generation of glucose-responsive functional islets with a three-dimensional structure from mouse fetal pancreatic cells and iPS cells in vitro
    Hiroki Saito
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    PLoS ONE 6:e28209. 2011
    ..Transplantation of the islets improved blood glucose levels in hyperglycemic mice. In conclusion, the two-step culture system allows the generation of functional islets with a 3D structure from iPS cells...
  22. doi request reprint Identification and isolation of adult liver stem/progenitor cells
    Minoru Tanaka
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Methods Mol Biol 826:25-32. 2012
    ..Here, we describe the identification and isolation of mouse liver stem/progenitor cells by utilizing antibodies against specific cell surface marker molecules...
  23. ncbi request reprint Development of murine hepatic sinusoidal endothelial cells characterized by the expression of hyaluronan receptors
    Hidenori Nonaka
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Dev Dyn 236:2258-67. 2007
    ..Our results provide new insight into the development of tissue-specific ECs and phenotypic criteria to distinguish HSECs from other types of ECs, including LECs...
  24. ncbi request reprint Junctional adhesion molecule-A, JAM-A, is a novel cell-surface marker for long-term repopulating hematopoietic stem cells
    Yasuyoshi Sugano
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Blood 111:1167-72. 2008
    ..Together, these results indicate that JAM-A is expressed on hematopoietic precursors in various hematopoietic tissues and is an excellent marker to isolate LTR-HSCs...
  25. doi request reprint Oncostatin M deficiency leads to thymic hypoplasia, accumulation of apoptotic thymocytes and glomerulonephritis
    Eiji Esashi
    Institute of Molecular and Cellular Biosciences, University of Tokyo Bunkyo ku, Tokyo, Japan
    Eur J Immunol 39:1664-70. 2009
    ..These results suggest that OSM plays a key role in the prevention of autoimmune disease by regulating the clearance of apoptotic thymocytes...
  26. doi request reprint Nephronectin is upregulated in acute and chronic hepatitis and aggravates liver injury by recruiting CD4 positive cells
    Fuyuki F Inagaki
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 430:751-6. 2013
    ..In addition, we reveal that Npnt expression is also upregulated in human hepatitis. Therefore, Npnt may be a potential therapeutic target for acute and chronic hepatitis...
  27. pmc Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development
    Keisuke Sekine
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    EMBO J 26:3607-15. 2007
    ..These results indicate that Foxo1 regulates gluconeogenesis cooperatively with C/EBPalpha, and also links insulin signaling to C/EBPalpha during liver development...
  28. pmc IkappaBeta, a nuclear IkappaB protein, positively regulates the NF-kappaB-mediated expression of proinflammatory cytokines
    Shumpei Yamauchi
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Bioscience, University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 107:11924-9. 2010
    ..These results indicate that IkappaBeta regulates the NF-kappaB-mediated transcription of a wide variety of proinflammatory genes, playing a crucial role in the regulation of innate immune responses...
  29. ncbi request reprint Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms
    Eiko Saijou
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 282:32327-37. 2007
    ..Taken together, these results identify EZI as a novel cargo protein for importin-7 and demonstrate a nucleocytoplasmic shuttling mechanism that is mediated by importin-7-dependent nuclear localization and CRM1-independent nuclear export...
  30. ncbi request reprint Tim2 is expressed in mouse fetal hepatocytes and regulates their differentiation
    Natsumi Watanabe
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Hepatology 45:1240-9. 2007
    ..Third, Tim2-hFc also inhibited proliferation of fetal hepatocytes. Fourth, down-regulation of Tim2 expression by small interfering RNA (siRNA) enhanced the expression of liver differentiation marker genes...
  31. ncbi request reprint Oncostatin m maintains the hematopoietic microenvironment and retains hematopoietic progenitors in the bone marrow
    Ken ichi Minehata
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Int J Hematol 84:319-27. 2006
    ..These results indicate that OSM plays a unique role in hematopoiesis by maintaining the proper microenvironment for BM hematopoiesis; it also retains hematopoietic progenitors in BM by regulating G-CSF and SDF-1 levels...
  32. ncbi request reprint Oncostatin M inhibits adipogenesis through the RAS/ERK and STAT5 signaling pathways
    Yuichiro Miyaoka
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 281:37913-20. 2006
    ..Taken together, our results indicate that OSM inhibits the onset of terminal differentiation of adipocytes through the Ras/ERK and STAT5 signaling pathways by possibly regulating C/EBPbeta activity...