Y Mitsuno

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Helicobacter pylori induced transactivation of SRE and AP-1 through the ERK signalling pathway in gastric cancer cells
    Y Mitsuno
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gut 49:18-22. 2001
  2. ncbi H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells
    S Maeda
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gastroenterology 119:97-108. 2000
  3. ncbi Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Pathol 55:286-93. 2002
  4. ncbi Helicobacter pylori activates the cyclin D1 gene through mitogen-activated protein kinase pathway in gastric cancer cells
    Y Hirata
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Infect Immun 69:3965-71. 2001
  5. ncbi cDNA microarray analysis of Helicobacter pylori-mediated alteration of gene expression in gastric cancer cells
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo, Bunkyo ku, 113 8655, Japan
    Biochem Biophys Res Commun 284:443-9. 2001
  6. ncbi Distinct mechanism of Helicobacter pylori-mediated NF-kappa B activation between gastric cancer cells and monocytic cells
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 276:44856-64. 2001
  7. ncbi Determination of Helicobacter pylori virulence by simple gene analysis of the cag pathogenicity island
    T Ikenoue
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Diagn Lab Immunol 8:181-6. 2001
  8. ncbi CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model
    W Shibata
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Pathol 210:306-14. 2006
  9. ncbi Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori
    S Maeda
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gut 50:771-8. 2002
  10. ncbi Systematic analysis of the TGF-beta-Smad signaling pathway in gastrointestinal cancer cells
    H Ijichi
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 289:350-7. 2001

Collaborators

Detail Information

Publications10

  1. ncbi Helicobacter pylori induced transactivation of SRE and AP-1 through the ERK signalling pathway in gastric cancer cells
    Y Mitsuno
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gut 49:18-22. 2001
    ..c-Fos is important for transactivation of AP-1 which has SRE in the promoter region. We conducted this study to confirm H pylori induced transactivation of these binding sites...
  2. ncbi H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells
    S Maeda
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gastroenterology 119:97-108. 2000
    ..The aim of this study was to analyze the molecular mechanism responsible for H. pylori-mediated NF-kappaB activation on gastric cancer cells...
  3. ncbi Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Pathol 55:286-93. 2002
    ..Although it is reported that Helicobacter pylori induces apoptosis on gastric epithelial cells, the mechanism remains unknown. Antiapoptotic effects generated by H pylori have not yet been evaluated...
  4. ncbi Helicobacter pylori activates the cyclin D1 gene through mitogen-activated protein kinase pathway in gastric cancer cells
    Y Hirata
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Infect Immun 69:3965-71. 2001
    ..pylori activates cyclin D1 through the mitogen-activated protein kinase pathway and not through NF-kappaB activation in AGS cells. This activation of cyclin D1 is partly dependent on the cag pathogenicity island but not on vacA...
  5. ncbi cDNA microarray analysis of Helicobacter pylori-mediated alteration of gene expression in gastric cancer cells
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo, Bunkyo ku, 113 8655, Japan
    Biochem Biophys Res Commun 284:443-9. 2001
    ..Taken together, these results indicate the importance of microarray technology as a tool for analyzing the complex interplay between H. pylori and the host...
  6. ncbi Distinct mechanism of Helicobacter pylori-mediated NF-kappa B activation between gastric cancer cells and monocytic cells
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 276:44856-64. 2001
    ..pylori-induced NF-kappaB activation in epithelial cells is dependent on cag PAI and contact but does not involve CD14 and IRAK, whereas in macrophage/monocytic cells it is independent of cag PAI or contact but involves CD14 and TLR4...
  7. ncbi Determination of Helicobacter pylori virulence by simple gene analysis of the cag pathogenicity island
    T Ikenoue
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Diagn Lab Immunol 8:181-6. 2001
    ..The cagE gene was a more accurate marker of an intact cag PAI than the cagA gene, and cagE seemed to be more useful in discriminating between H. pylori strains causing different rates of disease progression...
  8. ncbi CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model
    W Shibata
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Pathol 210:306-14. 2006
    ..It is concluded that CagA protein may be essential for the induction of severe gastritis in the Mongolian gerbil model...
  9. ncbi Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori
    S Maeda
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gut 50:771-8. 2002
    ..Although it is reported that Helicobacter pylori induces apoptosis on gastric epithelial cells, the mechanism remains unknown. Antiapoptotic effects generated by H pylori have not yet been evaluated...
  10. ncbi Systematic analysis of the TGF-beta-Smad signaling pathway in gastrointestinal cancer cells
    H Ijichi
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 289:350-7. 2001
    ....