Yasushi Matsuzaki

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Dehydroepiandrosterone and its derivatives: potentially novel anti-proliferative and chemopreventive agents
    Y Matsuzaki
    Division of Gastroenterology and Hepatology, Tokyo Medical University, Kasumigaura Hospital, 3 20 1 Ami Machi Chuoh, Inashikigun, Ibaraki 300 0395, Japan
    Curr Pharm Des 12:3411-21. 2006
  2. ncbi request reprint Decreased taurine concentration in skeletal muscles after exercise for various durations
    Yasushi Matsuzaki
    Departments of Gastroenterology and Orthopaedics, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Med Sci Sports Exerc 34:793-7. 2002
  3. ncbi request reprint Simultaneous determination of dehydroepiandrosterone and its 7-oxygenated metabolites in human serum by high-resolution gas chromatography--mass spectrometry
    Yasushi Matsuzaki
    Department of Gastroenterology and Hepatology, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Steroids 69:817-24. 2004
  4. ncbi request reprint Selective inhibition of CYP27A1 and of chenodeoxycholic acid synthesis in cholestatic hamster liver
    Yasushi Matsuzaki
    Department of Gastroenterology and Hepatology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, 305 8575 Ibaraki, Japan
    Biochim Biophys Acta 1588:139-48. 2002
  5. doi request reprint Proton-beam therapy for hepatocellular carcinoma associated with portal vein tumor thrombosis
    Shinji Sugahara
    Department of Radiation Oncology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Strahlenther Onkol 185:782-8. 2009
  6. pmc Proton beam therapy for hepatocellular carcinoma patients with severe cirrhosis
    Masaharu Hata
    Proton Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Strahlenther Onkol 182:713-20. 2006
  7. ncbi request reprint Proton beam therapy for hepatocellular carcinoma with inferior vena cava tumor thrombus: report of three cases
    Masashi Mizumoto
    Proton Medical Research Center, University of Tsukuba, Tennoudai, Tsukuba, Ibaraki, Japan
    Jpn J Clin Oncol 37:459-62. 2007
  8. pmc Liquid chromatography assay for routine monitoring of cellular ribavirin levels in blood
    Yoichi Inoue
    Department of Pharmaceutical Sciences, Institute of Clinical Medicine, University of Tsukuba, Ten nodai 1 1 1, Tsukuba, Ibaraki 305 8575, Japan
    Antimicrob Agents Chemother 48:3813-6. 2004
  9. doi request reprint Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS
    Akira Honda
    Center for Collaborative Research, Tokyo Medical University, Kasumigaura Hospital, Ami, Ibaraki 300 0395, Japan
    J Lipid Res 50:350-7. 2009
  10. pmc Cholesterol 25-hydroxylation activity of CYP3A
    Akira Honda
    Department of Gastroenterology, Center for Collaborative Research, Ibaraki 300 0395, Japan
    J Lipid Res 52:1509-16. 2011

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Dehydroepiandrosterone and its derivatives: potentially novel anti-proliferative and chemopreventive agents
    Y Matsuzaki
    Division of Gastroenterology and Hepatology, Tokyo Medical University, Kasumigaura Hospital, 3 20 1 Ami Machi Chuoh, Inashikigun, Ibaraki 300 0395, Japan
    Curr Pharm Des 12:3411-21. 2006
    ..However, to design potent and safe DHEA derivatives, identification of the DHEA receptor and clarification of the mechanisms of DHEA action are required...
  2. ncbi request reprint Decreased taurine concentration in skeletal muscles after exercise for various durations
    Yasushi Matsuzaki
    Departments of Gastroenterology and Orthopaedics, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Med Sci Sports Exerc 34:793-7. 2002
    ..To examine the changes of taurine concentrations in blood and skeletal muscles after transient exercise...
  3. ncbi request reprint Simultaneous determination of dehydroepiandrosterone and its 7-oxygenated metabolites in human serum by high-resolution gas chromatography--mass spectrometry
    Yasushi Matsuzaki
    Department of Gastroenterology and Hepatology, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Steroids 69:817-24. 2004
    ..The present method made it possible to determine simultaneously serum DHEA-related steroid levels with sufficient sensitivity and accuracy...
  4. ncbi request reprint Selective inhibition of CYP27A1 and of chenodeoxycholic acid synthesis in cholestatic hamster liver
    Yasushi Matsuzaki
    Department of Gastroenterology and Hepatology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, 305 8575 Ibaraki, Japan
    Biochim Biophys Acta 1588:139-48. 2002
    ..The suppression of CYP27A1 is, at least in part, responsible for the relative decreased production of CDCA and increased CA/CDCA ratio in the liver, bile and serum of cholestatic hamsters...
  5. doi request reprint Proton-beam therapy for hepatocellular carcinoma associated with portal vein tumor thrombosis
    Shinji Sugahara
    Department of Radiation Oncology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Strahlenther Onkol 185:782-8. 2009
    ..The authors performed a retrospective review to evaluate the efficacy of proton-beam therapy (PBT) for patients presenting with PVTT in the setting of HCC...
  6. pmc Proton beam therapy for hepatocellular carcinoma patients with severe cirrhosis
    Masaharu Hata
    Proton Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Strahlenther Onkol 182:713-20. 2006
    ..However, the survival of severe cirrhotic patients has recently improved due to advanced treatments. The aim of this study was to define the role of proton beam therapy for HCC patients with severe cirrhosis...
  7. ncbi request reprint Proton beam therapy for hepatocellular carcinoma with inferior vena cava tumor thrombus: report of three cases
    Masashi Mizumoto
    Proton Medical Research Center, University of Tsukuba, Tennoudai, Tsukuba, Ibaraki, Japan
    Jpn J Clin Oncol 37:459-62. 2007
    ..These cases suggest that proton beam therapy is safe and effective for patients with HCC associated with IVCTT...
  8. pmc Liquid chromatography assay for routine monitoring of cellular ribavirin levels in blood
    Yoichi Inoue
    Department of Pharmaceutical Sciences, Institute of Clinical Medicine, University of Tsukuba, Ten nodai 1 1 1, Tsukuba, Ibaraki 305 8575, Japan
    Antimicrob Agents Chemother 48:3813-6. 2004
    ..9 to 5.8% and 4.3 to 8.3%, respectively. We tested this method by monitoring blood ribavirin concentrations in two hepatitis C patients receiving alpha interferon 2b-plus-ribavirin combination therapy...
  9. doi request reprint Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS
    Akira Honda
    Center for Collaborative Research, Tokyo Medical University, Kasumigaura Hospital, Ami, Ibaraki 300 0395, Japan
    J Lipid Res 50:350-7. 2009
    ..7% to 107.3%, with a mean recovery of 100.6%. This method provides reproducible and reliable results for the quantification of oxysterols in small amounts of biological samples...
  10. pmc Cholesterol 25-hydroxylation activity of CYP3A
    Akira Honda
    Department of Gastroenterology, Center for Collaborative Research, Ibaraki 300 0395, Japan
    J Lipid Res 52:1509-16. 2011
    ..650, P < 0.0001, n = 78), but did not significantly correlate with the levels of 27-hydroxycholesterol or 24S-hydroxycholesterol. These results demonstrate the significance of CYP3A on the production of 25-hydroxycholesterol...
  11. doi request reprint Anticholestatic effects of bezafibrate in patients with primary biliary cirrhosis treated with ursodeoxycholic acid
    Akira Honda
    Department of Gastroenterology, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan Joint Research Center, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan
    Hepatology 57:1931-41. 2013
    ..Conclusion: Bezafibrate is a dual PPARs/PXR agonist with potent anticholestatic efficacy in early-stage PBC patients with an incomplete biochemical response to UDCA monotherapy. (HEPATOLOGY 2013)...
  12. doi request reprint Proton beam therapy for large hepatocellular carcinoma
    Shinji Sugahara
    Department of Radiation Oncology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Int J Radiat Oncol Biol Phys 76:460-6. 2010
    ..To investigate the safety and efficacy of proton beam therapy (PBT) in patients with large hepatocellular carcinoma (HCC)...
  13. doi request reprint Proton beam therapy for hepatocellular carcinoma located adjacent to the alimentary tract
    Hidetsugu Nakayama
    Department of Radiation Oncology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Int J Radiat Oncol Biol Phys 80:992-5. 2011
    ..To evaluate the safety and effectiveness of proton beam therapy for hepatocellular carcinoma (HCC) located adjacent to the alimentary tract...
  14. ncbi request reprint Hypercholesterolemia in rats with hepatomas: increased oxysterols accelerate efflux but do not inhibit biosynthesis of cholesterol
    Takeshi Hirayama
    Division of Gastroenterology and Hepatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, and Kasumigaura Hospital, Ibaraki, Japan
    Hepatology 44:602-11. 2006
    ..Overexpression of the SREBP processing system contributed to the activation of LXRalpha by maintaining high oxysterol levels in tissue...
  15. ncbi request reprint Repeated proton beam therapy for hepatocellular carcinoma
    Takayuki Hashimoto
    Proton Medical Research Center, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Int J Radiat Oncol Biol Phys 65:196-202. 2006
    ..To retrospectively evaluate the safety and effectiveness of repeated proton beam therapy for newly developed or recurrent hepatocellular carcinoma (HCC)...
  16. ncbi request reprint Proton beam therapy for hepatocellular carcinoma with portal vein tumor thrombus
    Masaharu Hata
    Proton Medical Research Center, University of Tsukuba, Tsukuba, Japan
    Cancer 104:794-801. 2005
    ..The authors conducted a retrospective review to determine the role of proton beam therapy in the treatment of patients who had HCC with PVTT...
  17. ncbi request reprint Neoplastic transformation and induction of H+,K+ -adenosine triphosphatase by N-methyl-N'-nitro-N-nitrosoguanidine in the gastric epithelial RGM-1 cell line
    Osamu Shimokawa
    Division of Gastroenterology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Ten nohdai, Tsukuba, Ibaraki, Japan
    In Vitro Cell Dev Biol Anim 44:26-30. 2008
    ..The results suggested that parent RGM-1 cells were gastric progenitor cells. This mutant RGK-1 cell line will contribute to future investigation on gastric carcinogenesis and to the development of other pathophysiologic fields...
  18. ncbi request reprint Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines
    Kaori Miyazaki
    Department of Gastroenterology, Graduate School of Comprehensive Human Science, University of Tsukuba, 1 1 1, Tennoudai, Tsukuba 305 8575, Japan
    J Gastroenterol 41:140-50. 2006
    ..e., dihydropyrimidine dehydrogenase (DPD), thymidylate synthase (TS), orotate phosphoribosyl transferase (OPRT), and thymidine phosphorylase (TP)...
  19. ncbi request reprint Proton beam therapy for hepatocellular carcinoma with limited treatment options
    Masaharu Hata
    Proton Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Cancer 107:591-8. 2006
    ..The authors conducted a retrospective review to define the usefulness of proton beam therapy for patients who had hepatocellular carcinoma (HCC) with limited treatment options...
  20. pmc Highly sensitive quantification of serum malonate, a possible marker for de novo lipogenesis, by LC-ESI-MS/MS
    Akira Honda
    Center for Collaborative Research, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan
    J Lipid Res 50:2124-30. 2009
    ..1 +/- 1.1 pmol, which was in complete agreement with the observed X(0) = 15.0 +/- 0.6 pmol, with a mean recovery of 96.0%. This method provides reliable and reproducible results for the quantification of MA in human serum...
  21. ncbi request reprint Anti-proliferative action of endogenous dehydroepiandrosterone metabolites on human cancer cell lines
    Shigemasa Yoshida
    Department of Gastroenterology and Hepatology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Steroids 68:73-83. 2003
    ..These non-androgenic DHEA metabolites may serve as chemopreventive or anti-proliferative therapies...
  22. ncbi request reprint Enhancement of DNA topoisomerase I inhibitor-induced apoptosis by ursodeoxycholic acid
    Tadashi Ikegami
    Division of Gastroenterology and Hepatology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Japan
    Mol Cancer Ther 5:68-79. 2006
    ..However, the use of this bile acid as an enhancer in antitumor chemotherapy should be further evaluated clinically...
  23. ncbi request reprint Involvement of integrin-linked kinase in carbon tetrachloride-induced hepatic fibrosis in rats
    Yining Zhang
    Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukaba City, and Division of Gastroenterology and Hepatology, Tokyo Medical University Kasumigaura Hospital, Japan
    Hepatology 44:612-22. 2006
    ..In conclusion, ILK plays a key role in HSC activation and could be a possible target for antifibrogenic therapy...
  24. doi request reprint Highly sensitive and specific analysis of sterol profiles in biological samples by HPLC-ESI-MS/MS
    Akira Honda
    Center for Collaborative Research, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki 300 0395, Japan
    J Steroid Biochem Mol Biol 121:556-64. 2010
    ..In addition, sufficient specificity of this method was achieved by selected reaction monitoring (SRM) and thorough chromatographic separation of each sterol...
  25. doi request reprint Clinical features of gastroduodenal ulcer in Japanese patients taking low-dose aspirin
    Junichi Iwamoto
    Department of Gastroenterology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan
    Dig Dis Sci 55:2270-4. 2010
    ..The risks of peptic ulcer complications increase in association with low-dose aspirin (LDA) use. The endoscopic findings and clinical features of gastroduodenal ulcer have not been thoroughly investigated in patients taking LDA...
  26. ncbi request reprint Apoptosis and inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone
    Yanfang Jiang
    Division of Gastroenterology and Hepatology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences and University Hospital, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, 305 8575, Japan
    J Gastroenterol 40:490-7. 2005
    ..The purpose of this study was to evaluate the effect of these steroids on proliferation in human cancer cell lines...
  27. ncbi request reprint Proton beam therapy for hepatocellular carcinoma: a retrospective review of 162 patients
    Toshiya Chiba
    Department of Gastroenterology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Clin Cancer Res 11:3799-805. 2005
    ..We present results of patients with hepatocellular carcinoma (HCC) treated with proton beam therapy...
  28. ncbi request reprint Rapid inhibition of MAPK signaling and anti-proliferation effect via JAK/STAT signaling by interferon-alpha in hepatocellular carcinoma cell lines
    Kentaro Inamura
    Department of Molecular Biology and Molecular Oncology, Graduate School of Comprehensive Human Science, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
    Biochim Biophys Acta 1745:401-10. 2005
    ....
  29. ncbi request reprint Increased expression of gallbladder cholecystokinin: a receptor in prairie dogs fed a high-cholesterol diet and its dissociation with decreased contractility in response to cholecystokinin
    Masahito Kano
    Department of Gastroenterology Surgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    J Lab Clin Med 139:285-94. 2002
    ....
  30. ncbi request reprint The clinical outcome of capsule endoscopy in patients with obscure gastrointestinal bleeding
    Junichi Iwamoto
    Department of Gastroenterology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan
    Hepatogastroenterology 58:301-5. 2011
    ..Capsule endoscopy (CE) represents a significant advance in the investigation of small bowel diseases. Little is known about the clinical outcome of patients with obscure gastrointestinal bleeding (OGIB)...
  31. doi request reprint Hepatitis C virus infection causes hypolipidemia regardless of hepatic damage or nutritional state: An epidemiological survey of a large Japanese cohort
    Teruo Miyazaki
    Department of Development for Community Medicine, Tokyo Medical University Center for Collaborative Research Department of Internal Medicine, Division of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center Ibaraki Prefectural Institute of Public Health, Mito Ibaraki Prefectural Central Hospital, Kasama, Japan
    Hepatol Res 41:530-41. 2011
    ..Conclusion:  This epidemiological survey in a large Japanese cohort suggests that the HCV infection itself might directly cause hypolipidemia, irrespective of host factors including age, hepatic damage and nutritional state...
  32. ncbi request reprint Efficacy of double filtration plasmapheresis with pegylated interferon/ribavirin therapy for intractable chronic hepatitis C patients and hepatitis C patients with combined liver cirrhosis by HBV, leading to early viral elimination
    Tadashi Ohara
    Department of Gastroenterology and Hepatology, Tokyo Medical University, Ibaraki Medical Center, 3 20 1 Chuo, Ami Machi, Inashiki Gun, Ibaraki 300 0395, Japan
    Hepatogastroenterology 58:133-6. 2011
    ..The therapeutic effects of concomitant treatment of such intractable patients with double-filtration plasmapheresis (DFPP) and pegylated interferon (PEG-IFN) alpha 2a/ribavirin (RBV) therapy were investigated...
  33. doi request reprint Increased serum liver X receptor ligand oxysterols in patients with non-alcoholic fatty liver disease
    Tadashi Ikegami
    Division of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, 3 20 1 Chuo, Ami Machi, Inashiki Gun, Ibaraki 300 0395, Japan
    J Gastroenterol 47:1257-66. 2012
    ....
  34. doi request reprint Highly sensitive analysis of sterol profiles in human serum by LC-ESI-MS/MS
    Akira Honda
    Center for Collaborative Research, Tokyo Medical University, Kasumigaura Hospital, Ami, Ibaraki 300 0395, Japan
    J Lipid Res 49:2063-73. 2008
    ....
  35. ncbi request reprint The associated markers and their limitations for the primary screening of HCV carriers in public health examination
    Teruo Miyazaki
    Department of Development for Community Medicine, Tokyo Medical University, Japan
    Hepatol Res 39:664-74. 2009
    ..Therefore, at present, an anti-HCV antibody test is required for the efficient screening of HCV carriers in all health examinations...
  36. ncbi request reprint Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS
    Akira Honda
    Department of Internal Medicine, Tokyo Medical University, Kasumigaura Hospital, Ami, Ibaraki 300 0395, Japan
    J Lipid Res 48:1212-20. 2007
    ..6%. This method made it possible to measure HMG-CoA reductase activity with a high degree of reproducibility and reliability, and especially with sensitivity superior to that of the conventional RI method...
  37. ncbi request reprint Serum concentration of 27-hydroxycholesterol predicts the effects of high-cholesterol diet on plasma LDL cholesterol level
    Takeshi Hirayama
    Department of Gastroenterology, Tokyo Medical University, Japan
    Hepatol Res 39:149-56. 2009
    ..The concentration of serum 27-hydroxycholesterol appears to reflect cholesterol saturation in the body and predicts to some extent a responsiveness to dietary cholesterol...
  38. ncbi request reprint Suppressive effect of ursodeoxycholic acid on type IIA phospholipase A2 expression in HepG2 cells
    Tadashi Ikegami
    Institute of Clinical Medicine, University of Tsukuba, Tsukuba City 305 0048, Japan
    Hepatology 41:896-905. 2005
    ..In conclusion, this study supports the possible alteration of arachidonic acid metabolism and PLA(2)IIA expression level, in particular, as the protective action of UDCA in patients with chronic liver disease...
  39. doi request reprint Bile acid malabsorption deactivates pregnane X receptor in patients with Crohn's disease
    Junichi Iwamoto
    Department of Gastroenterology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan
    Inflamm Bowel Dis 19:1278-84. 2013
    ..Because bile acid malabsorption is one of the features of CD and bile acids are potential activators of PXR, we explored the relationship between bile acid malabsorption and PXR activities in patients with CD...
  40. ncbi request reprint [Bile acid, bile acid profile, and various conjugated fractions]
    Yasushi Matsuzaki
    Division of Gastroenterology and Hepatology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences and University Hospital, University of Tsukuba
    Nihon Rinsho 62:64-7. 2004
  41. doi request reprint The role of taurine on skeletal muscle cell differentiation
    Teruo Miyazaki
    Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan
    Adv Exp Med Biol 776:321-8. 2013
    ....
  42. ncbi request reprint Metabolism and hepatic toxicity of flutamide in cytochrome P450 1A2 knockout SV129 mice
    Yasushi Matsuzaki
    Department of Gastroenterology and Hepatology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, 305 8575, Japan
    J Gastroenterol 41:231-9. 2006
    ..We hypothesized that another subsidiary metabolite might be responsible for induction of hepatotoxicity...
  43. ncbi request reprint Impact of determination of hepatitis B virus subgenotype and pre-core/core-promoter mutation for the prediction of acute exacerbation of asymptomatic carriers
    Tadashi Ikegami
    Division of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan
    Hepatol Res 39:341-5. 2009
    ..Conclusion: This result suggests that determination of the HBV subgenotype and pre-core/core promoter mutations could provide a rationale for development of a treatment strategy in asymptomatic HBV carriers...
  44. ncbi request reprint Liver fibrosis: possible involvement of EMT
    Tadashi Ikegami
    Division of Gastroenterology and Hepatology, Tokyo Medical University, Kasumigaura Hospital, Inashiki Gun, Japan
    Cells Tissues Organs 185:213-21. 2007
    ....
  45. ncbi request reprint Highly sensitive quantification of 7alpha-hydroxy-4-cholesten-3-one in human serum by LC-ESI-MS/MS
    Akira Honda
    Ibaraki Prefectural Institute of Public Health, Mito, Ibaraki 310 0852, Japan
    J Lipid Res 48:458-64. 2007
    ..3 +/- 1.0 ng/ml with a mean recovery of 93.4%. This method provides highly reliable and reproducible results for the quantification of C4, especially in small volumes of blood samples...
  46. ncbi request reprint Disrupted coordinate regulation of farnesoid X receptor target genes in a patient with cerebrotendinous xanthomatosis
    Akira Honda
    Ibaraki Prefectural Institute of Public Health, Mito, Ibaraki 310 0852, Japan
    J Lipid Res 46:287-96. 2005
    ..The mechanism of the disruption may be explained by a normally stimulated FXR pathway attributable to markedly increased bile alcohols with activation of HNF4alpha caused by reduced bile acids in CTX liver...
  47. ncbi request reprint Monitoring of hepatocellular carcinoma, following proton radiotherapy, with contrast-enhanced color Doppler ultrasonography
    Gaku Niizawa
    Division of Gastroenterology and Hepatology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences and University Hospital, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, 305 8575, Japan
    J Gastroenterol 40:283-90. 2005
    ..The aim of this study was to determine the usefulness of CECDU in assessing the therapeutic response of HCC treated with proton radiotherapy...
  48. doi request reprint Additional effects of taurine on the benefits of BCAA intake for the delayed-onset muscle soreness and muscle damage induced by high-intensity eccentric exercise
    Song Gyu Ra
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Adv Exp Med Biol 776:179-87. 2013
    ..In conclusion, additional supplement of TAU with BCAA would be a useful way to attenuate DOMS and muscle damages induced by high-intensity exercise...
  49. pmc Clinical features of gastroduodenal injury associated with long-term low-dose aspirin therapy
    Junichi Iwamoto
    Junichi Iwamoto, Yoshifumi Saito, Akira Honda, Yasushi Matsuzaki, Department of Gastroenterology, Tokyo Medical University, Ibaraki Medical Center, Ibaraki 300 0395, Japan
    World J Gastroenterol 19:1673-82. 2013
    ..It is very important to prevent LDA-induced gastroduodenal ulcer complications including bleeding, and every effort should be exercised to prevent the bleeding complications...
  50. doi request reprint The effects of cyclooxygenase2-prostaglandinE2 pathway on Helicobacter pylori-induced urokinase-type plasminogen activator system in the gastric cancer cells
    Junichi Iwamoto
    Department of Gastroenterology, Kasumigaura Hospital, Tokyo Medical University, Tokyo, Japan
    Helicobacter 13:174-82. 2008
    ..The induction of uPA and uPAR in the gastric cancer cells with H. pylori has been demonstrated previously. The involvement of COX-2-PGE2 pathway in the uPA system (uPA and uPAR) expression is unclear...
  51. pmc Therapeutic barium enema for bleeding colonic diverticula: four case series and review of the literature
    Jun ichi Iwamoto
    Department of Gastroenterology, Tokyo Medical University Kasumigaura Hospital, Ibaraki 300 0395, Japan
    World J Gastroenterol 14:6413-7. 2008
    ..These patients remained free of re-bleeding in the follow-up period (range 17-35 mo) after the therapy. We report the four case series of therapeutic barium enema and reviewed the literature pertinent to this procedure...
  52. ncbi request reprint Origin of oxysterols in hepatic bile of patients with biliary infection
    Tadashi Yoshida
    Division of Gastroenterology, Tsukuba Memorial Hospital and Institute of Clinical Medicine, University of Tsukuba, Japan
    Am J Gastroenterol 98:2275-80. 2003
    ..The purpose of this study was to determine if infection of the biliary tract was associated with increased concentrations of oxysterols in the bile and, if so, which oxysterols showed a significant change...
  53. ncbi request reprint Effects of taurine administration in rat skeletal muscles on exercise
    Yoshihisa Yatabe
    Department of Orthopaedic Surgery, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8575, Japan
    J Orthop Sci 8:415-9. 2003
    ..We concluded that peroral administration of taurine maintains the taurine concentration in skeletal muscle on exercise and up-regulates physical endurance...
  54. ncbi request reprint Marked elevation of erythrocyte ribavirin levels in interferon and ribavirin-induced anemia
    Masato Homma
    Department of Pharmaceutical Sciences, University of Tsukuba, Ibaraki, Japan
    Clin Gastroenterol Hepatol 2:337-9. 2004
    ....
  55. ncbi request reprint Effective gene therapy of biliary tract cancers by a conditionally replicative adenovirus expressing uracil phosphoribosyltransferase: significance of timing of 5-fluorouracil administration
    Emiko Seo
    Division of Gastroenterology and Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    Cancer Res 65:546-52. 2005
    ..This gene therapy with appropriately timed administration of 5-FU should be useful in overcoming the resistance of biliary cancers to 5-FU...
  56. doi request reprint Cholesterol and chronic hepatitis C virus infection
    Akira Honda
    Department of Gastroenterology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan
    Hepatol Res 41:697-710. 2011
    ..Other compounds that block various steps of cholesterol metabolic pathways have also been studied to develop new strategies for the complete eradication of this virus...
  57. ncbi request reprint Ursodeoxycholic acid: Mechanism of action and novel clinical applications
    Tadashi Ikegami
    Division of Gastroenterology and Hepatology, Tokyo Medical University, Kasumigaura Hospital, Ibaraki, Japan
    Hepatol Res 38:123-31. 2008
    ..In this review, we summarize the proposed molecular mechanisms for the action of UDCA, especially in hepatocytes, and also discuss the putative future clinical usage of this unique drug...
  58. ncbi request reprint Rebamipide significantly inhibits indomethacin-induced mitochondrial damage, lipid peroxidation, and apoptosis in gastric epithelial RGM-1 cells
    Yumiko Nagano
    Division of Gastroenterology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Ten nohdai, Tsukuba, Ibaraki 305 8575, Japan
    Dig Dis Sci 50:S76-83. 2005
    ..Rebamipide exerts a protective effect on mitochondrial membrane stability in gastric epithelial cells...
  59. ncbi request reprint Identification of novel hepatitis C virus-specific cytotoxic T lymphocyte epitopes by ELISpot assay using peptides with human leukocyte antigen-A*2402-binding motifs
    Taku Hakamada
    Division of Gastroenterology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
    J Gen Virol 85:1521-31. 2004
    ..Patients with short-term HCV infection are suitable for searching for novel HCV epitopes, but peripheral blood HCV-specific CD8(+) T cells decrease markedly after loss of antigenic stimulation...
  60. ncbi request reprint FXR-mediated down-regulation of CYP7A1 dominates LXRalpha in long-term cholesterol-fed NZW rabbits
    Guorong Xu
    Medical Service, Veteran s Administration Medical Center, East Orange, NJ 07018, USA
    J Lipid Res 44:1956-62. 2003
    ..Thus, in rabbits, when FXR and LXRalpha are activated simultaneously, the inhibitory effect of FXR overrides the stimulatory effect of LXRalpha to suppress CYP7A1 mRNA expression...
  61. ncbi request reprint Dietary cholesterol stimulates CYP7A1 in rats because farnesoid X receptor is not activated
    Guorong Xu
    Gastrointestinal Lab 15A Veterans Affairs Medical Center, 385 Tremont Ave, East Orange, NJ 07018 1095, USA
    Am J Physiol Gastrointest Liver Physiol 286:G730-5. 2004
    ..In rats fed Ch + CA, the bile acid pool expanded, which activated FXR to offset the stimulatory effects of LXR-alpha on CYP7A1...
  62. ncbi request reprint Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits
    Akira Honda
    Ibaraki Prefectural Institute of Public Health, Mito, Japan
    Metabolism 53:42-8. 2004
    ..In contrast, 27-hydroxycholesterol and 3beta-hydroxy-5-cholestenoic acid levels in plasma did not reflect hepatic sterol 27-hydroxylase activities even if the levels were adjusted to plasma cholesterol concentrations...
  63. ncbi request reprint The harmful effect of exercise on reducing taurine concentration in the tissues of rats treated with CCl4 administration
    Teruo Miyazaki
    Ibaraki Prefectural Institute of Public Health, Mito, Japan
    J Gastroenterol 39:557-62. 2004
    ..The aim of this study was to examine taurine concentration in various tissues of a liver damaged with fibrosis (LD) in a rat model before and after exercise...
  64. doi request reprint Vitamin D(3) inhibits expression of bullous pemphigoid antigen 1 through post-transcriptional mechanism without new protein synthesis
    Chiaki Yamamoto
    J Dermatol Sci 50:155-8. 2008
  65. ncbi request reprint Interferon-gamma down-regulates expression of the 230-kDa bullous pemphigoid antigen gene (BPAG1) in epidermal keratinocytes via novel chimeric sequences of ISRE and GAS
    Takahide Kaneko
    Department of Dermatology, Hirosaki University School of Medicine, Hirosaki, Japan
    Exp Dermatol 15:308-14. 2006
    ..Our findings provide novel insight into the mechanism of IFNgamma regulation in keratinocyte differentiation and proliferation...
  66. ncbi request reprint Taurine inhibits oxidative damage and prevents fibrosis in carbon tetrachloride-induced hepatic fibrosis
    Teruo Miyazaki
    Ibaraki Prefectural Institute of Public Health, Mito, Japan
    J Hepatol 43:117-25. 2005
    ..The aim of the study was to examine the effects of taurine on hepatic fibrogenesis and in isolated hepatic stellate cells (HSC)...
  67. ncbi request reprint Colestimide: the efficacy of a novel anion-exchange resin in cholestatic disorders
    Yasushi Matsuzaki
    J Gastroenterol Hepatol 17:1133-5. 2002
  68. ncbi request reprint Keratinocyte responsive element 3: analysis of a keratinocyte-specific regulatory sequence in the 230-kDa bullous pemphigoid antigen gene promoter
    Yasushi Matsuzaki
    Department of Dermatology, Hirosaki University School of Medicine, Hirosaki, Japan
    J Invest Dermatol 120:308-12. 2003
    ..These data suggest that keratinocyte responsive element 3 functions as a position-, copy number-, and orientation-dependent cis-element contributing to tissue-specific regulation of the 230-kDa bullous pemphigoid antigen gene...
  69. ncbi request reprint Tissue-specific expression of the ABCC6 gene
    Yasushi Matsuzaki
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Invest Dermatol 125:900-5. 2005
    ..The results have implications for mutation detection strategies in PXE by RT-PCR, and they further support the notion that PXE is a primary metabolic disorder...
  70. ncbi request reprint Transcriptional regulation and characterization of the promoter region of the human ABCC6 gene
    Qiujie Jiang
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Invest Dermatol 126:325-35. 2006
    ..These findings may have implications for phenotypic expression of heritable and acquired diseases involving abnormality in the ABCC6 gene...
  71. ncbi request reprint Human metallothionein gene expression is upregulated by beta-thujaplicin: possible involvement of protein kinase C and reactive oxygen species
    Hajime Nakano
    Department of Dermatology, Hirosaki University School of Medicine, Hirosaki, Japan
    Biol Pharm Bull 29:55-9. 2006
    ..BT may be a useful tool for dissecting the signal transduction pathway mediating MT-IIA promoter activation...
  72. pmc Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues
    John F Klement
    Department of Dermatology, Jefferson Medical College, 233 S 10th Street, Suite 322 BLSB, Philadelphia, PA 19107, USA
    Mol Cell Biol 25:8299-310. 2005
    ..These data demonstrate aberrant mineralization of soft tissues in PXE-affected organs, and, consequently, these mice recapitulate features of this complex disease...