Akira Matsumura

Summary

Affiliation: University of Tsukuba
Country: Japan

Publications

  1. ncbi request reprint [Anti-angiogenesis treatment for brain tumors: present and future]
    Shingo Takano
    Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba City, Ibaraki 305 8575, Japan
    No Shinkei Geka 34:657-78. 2006
  2. pmc Prognostic factors in glioblastoma multiforme patients receiving high-dose particle radiotherapy or conventional radiotherapy
    M Matsuda
    Department of Neurosurgery, University Hospital of Tsukuba, Tennodai 1 1 1, Tsukuba, Ibaraki, Japan
    Br J Radiol 84:S54-60. 2011
  3. doi request reprint Current practices and future directions of therapeutic strategy in glioblastoma: survival benefit and indication of BNCT
    Akira Matsumura
    Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, Tennodai 1 1 1, Tsukuba City, Ibaraki 305 8575, Japan
    Appl Radiat Isot 67:S12-4. 2009
  4. ncbi request reprint Preoperative endovascular embolization for hemangioblastoma in the posterior fossa
    Noriaki Sakamoto
    Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki
    Neurol Med Chir (Tokyo) 52:878-84. 2012
  5. doi request reprint Metronomic treatment of malignant glioma xenografts with irinotecan (CPT-11) inhibits angiogenesis and tumor growth
    Shingo Takano
    Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba City, Ibaraki 305 8575, Japan
    J Neurooncol 99:177-85. 2010
  6. ncbi request reprint [Usefulness of quantitative H-MR spectroscopy for the differentiation between radiation necrosis and recurrence of anaplastic oligodendroglioma]
    Tomonori Isobe
    Graduate School of Human Comprehensive Sciences, University of Tsukuba, Ibaraki, Japan
    No Shinkei Geka 39:485-90. 2011
  7. ncbi request reprint Pathological changes after autologous formalin-fixed tumor vaccine therapy combined with temozolomide for glioblastoma - three case reports -
    Noriaki Sakamoto
    Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 51:319-25. 2011
  8. doi request reprint Combined use of sodium borocaptate and buthionine sulfoximine in boron neutron capture therapy enhanced tissue boron uptake and delayed tumor growth in a rat subcutaneous tumor model
    Fumiyo Yoshida
    University of Tsukuba, Graduate School of Comprehensive Human Sciences, Functional and Regulatory Medical Sciences, Tennodai 1 1 1, Tsukuba, Ibaraki 305 8575, Japan
    Cancer Lett 263:253-8. 2008
  9. doi request reprint T2 corrected quantification method of L-p-boronophenylalanine using proton magnetic resonance spectroscopy for boron neutron capture therapy
    Yohei Yamamoto
    Department of Neurosurgery, Institute of Clinical Medicine, Graduated School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, Japan
    Appl Radiat Isot 67:S345-7. 2009
  10. ncbi request reprint Spinal dural arteriovenous fistula with lipomyelodysplasia
    Masayuki Sato
    Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 53:107-9. 2013

Detail Information

Publications89

  1. ncbi request reprint [Anti-angiogenesis treatment for brain tumors: present and future]
    Shingo Takano
    Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba City, Ibaraki 305 8575, Japan
    No Shinkei Geka 34:657-78. 2006
  2. pmc Prognostic factors in glioblastoma multiforme patients receiving high-dose particle radiotherapy or conventional radiotherapy
    M Matsuda
    Department of Neurosurgery, University Hospital of Tsukuba, Tennodai 1 1 1, Tsukuba, Ibaraki, Japan
    Br J Radiol 84:S54-60. 2011
    ..Randomised trials with strictly controlled inclusion criteria to ensure the comparable selection of patients are required to demonstrate conclusively that prolonged survival can be attributed to high-dose particle radiotherapies...
  3. doi request reprint Current practices and future directions of therapeutic strategy in glioblastoma: survival benefit and indication of BNCT
    Akira Matsumura
    Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, Tennodai 1 1 1, Tsukuba City, Ibaraki 305 8575, Japan
    Appl Radiat Isot 67:S12-4. 2009
    ..5-25 M) of previously reported may still be comparable to that of BNCT. Randomized trials of comparably selected patients are required to demonstrate conclusively that prolonged survival is a result of this tumor-selective radiotherapy...
  4. ncbi request reprint Preoperative endovascular embolization for hemangioblastoma in the posterior fossa
    Noriaki Sakamoto
    Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki
    Neurol Med Chir (Tokyo) 52:878-84. 2012
    ..In our series, presurgical embolization using NBCA made tumor removal safe and reduced bleeding volume in posterior fossa HBs...
  5. doi request reprint Metronomic treatment of malignant glioma xenografts with irinotecan (CPT-11) inhibits angiogenesis and tumor growth
    Shingo Takano
    Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba City, Ibaraki 305 8575, Japan
    J Neurooncol 99:177-85. 2010
    ..These angiosuppressive effects of CPT-11 show promise for another use of CPT-11 in metronomic and scheduled angiosuppressive chemotherapy with low dose and long-term administration for malignant gliomas without systemic side effects...
  6. ncbi request reprint [Usefulness of quantitative H-MR spectroscopy for the differentiation between radiation necrosis and recurrence of anaplastic oligodendroglioma]
    Tomonori Isobe
    Graduate School of Human Comprehensive Sciences, University of Tsukuba, Ibaraki, Japan
    No Shinkei Geka 39:485-90. 2011
    ..The histological findings of this lesion showed a diffuse proliferation of recurrent tumor cells. Quantitative 1H-MRS is a useful tool for the differentiation between radiation necrosis and recurrent tumors...
  7. ncbi request reprint Pathological changes after autologous formalin-fixed tumor vaccine therapy combined with temozolomide for glioblastoma - three case reports -
    Noriaki Sakamoto
    Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 51:319-25. 2011
    ..CD3(+)CD8(+) lymphocytes were frequently detected in surgical specimens and MIB-1 labeling index in 2 cases decreased after AFTV/TMZ therapy. AFTV/TMZ therapy is suitable for larger scale clinical trials...
  8. doi request reprint Combined use of sodium borocaptate and buthionine sulfoximine in boron neutron capture therapy enhanced tissue boron uptake and delayed tumor growth in a rat subcutaneous tumor model
    Fumiyo Yoshida
    University of Tsukuba, Graduate School of Comprehensive Human Sciences, Functional and Regulatory Medical Sciences, Tennodai 1 1 1, Tsukuba, Ibaraki 305 8575, Japan
    Cancer Lett 263:253-8. 2008
    ..Tumor growth was significantly delayed by using BSO. With further improvement in experimental conditions, radiation exposure time, together with radiation damage to normal tissues, could be reduced...
  9. doi request reprint T2 corrected quantification method of L-p-boronophenylalanine using proton magnetic resonance spectroscopy for boron neutron capture therapy
    Yohei Yamamoto
    Department of Neurosurgery, Institute of Clinical Medicine, Graduated School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, Japan
    Appl Radiat Isot 67:S345-7. 2009
    ..Therefore, our results indicate that proton MRS can be potentially useful technique for in vivo BPA quantification in boron neutron capture therapy (BNCT)...
  10. ncbi request reprint Spinal dural arteriovenous fistula with lipomyelodysplasia
    Masayuki Sato
    Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 53:107-9. 2013
    ..Embolization of the spinal dural AVF was successfully performed, and is an optional treatment for coexisting spinal dural AVF and lipomyelocele in adults...
  11. ncbi request reprint Multimodality treatment for cerebral arteriovenous malformations: complementary role of proton beam radiotherapy
    Yasunobu Nakai
    Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki
    Neurol Med Chir (Tokyo) 52:859-64. 2012
    ..Fractionated PB radiotherapy for cerebral AVMs seems to be useful for the treatment of large AVMs, but careful long-term follow up is required to establish the efficacy and safety...
  12. doi request reprint Elevated diffusion anisotropy in gray matter and the degree of brain compression
    Satoru Osuka
    Department of Neurosurgery, University of Tsukuba, Tsukuba, Japan
    J Neurosurg 117:363-71. 2012
    ..In this study, the authors evaluated whether DTI can precisely define the degree of tissue compression in patients with chronic subdural hematoma (CSDH)...
  13. ncbi request reprint Prediction of boron concentrations in blood from patients on boron neutron capture therapy
    Yasushi Shibata
    Department of Neurosurgery, University of Tsukuba, Tsukuba, Ibaraki, 305 8575, Japan
    Anticancer Res 23:5231-5. 2003
    ..In boron neutron capture therapy, blood boron concentration is the key factor to calculate radiation dose, however, blood sampling is difficult during neutron irradiation...
  14. doi request reprint Decrease in the apparent diffusion coefficient in peritumoral edema for the assessment of recurrent glioblastoma treated by bevacizumab
    Shingo Takano
    Department of Neurosurgery, University of Tsukuba, Tsukuba City, Ibaraki, Japan
    Acta Neurochir Suppl 118:185-9. 2013
    ..Anti-edema effect of bevacizumab was evaluated using the apparent diffusion coefficient (ADC) of peritumoral edema associated with regional cerebral blood flow (rCBV) of the tumor...
  15. doi request reprint Feasibility of boron neutron capture therapy for malignant spinal tumors
    Kei Nakai
    Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Appl Radiat Isot 67:S43-6. 2009
    ..3 Gy-Eq as a maximum normal spinal dose. The BNCT for the spinal cord tumor was therefore feasible when a sufficient T/N ratio could be achieved. The use of F-BPA PET imaging for spinal tumor patients is supported by this study...
  16. doi request reprint Boron neutron capture therapy for newly diagnosed glioblastoma
    Tetsuya Yamamoto
    Department of Neurosurgery, University of Tsukuba, Tsukuba City, Japan
    Radiother Oncol 91:80-4. 2009
    ..The efficacy, safety, and dose distribution of neutron capture therapy (NCT) were evaluated in 15 patients with newly diagnosed glioblastoma...
  17. doi request reprint Evaluation of ventriculomegaly using diffusion tensor imaging: correlations with chronic hydrocephalus and atrophy
    Satoru Osuka
    Department of Neurosurgery, University of Tsukuba, Tsukuba, Japan
    J Neurosurg 112:832-9. 2010
    ..In this preliminary study, the authors compared the DT imaging findings of ventriculomegaly with those of chronic hydrocephalus or atrophy to clarify the potential of diffusion anisotropy in the identification of hydrocephalus...
  18. doi request reprint New observations concerning the interpretation of magnetic resonance spectroscopy of meningioma
    Qiang Yue
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba Science City, Ibaraki, 305 8575, Japan
    Eur Radiol 18:2901-11. 2008
    ..1H-MRS reflects some distinctive biochemical and pathological changes of meningiomas that might be misinterpreted...
  19. ncbi request reprint [Intracerebral xanthogranuloma with specific MRI features: a case report]
    Junzo Nakao
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan
    No Shinkei Geka 39:1091-7. 2011
    ..The pathological diagnosis was xanthogranuloma in the brain. Postoperative course was uneventful. The frontal residual mass lesion decreased in size and Gd-enhancement...
  20. ncbi request reprint Endoscopic third ventriculostomy for obstructive hydrocephalus caused by a large upper basilar artery aneurysm after coil embolization
    Masayuki Sato
    Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 52:832-4. 2012
    ..If there is sufficient space in the prepontine cistern for the surgical procedure, ETV is a good choice for the treatment of obstructive hydrocephalus associated with cerebral aneurysms...
  21. ncbi request reprint Acute subdural hematoma without subarachnoid hemorrhage caused by ruptured A1-A2 junction aneurysm. Case report
    Tomoya Takada
    Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 52:430-4. 2012
    ....
  22. ncbi request reprint New instrument for creating bone graft cavities for anterior cervical decompression and fusion: the anterior fusion spinal fork
    Tomosato Yamazaki
    Department of Neurosurgery, National Hospital Organization, Mito Medical Center, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 52:691-4. 2012
    ..This simple instrument allowed us to design and construct a bone graft cavity of the correct size and shape for iliac bone graft or bone graft substitutes for anterior cervical spine surgery...
  23. doi request reprint Immunohistochemical detection of IDH1 mutation, p53, and internexin as prognostic factors of glial tumors
    Shingo Takano
    Department of Neurological Surgery, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, 305 8575, Ibaraki, Tsukuba, Japan
    J Neurooncol 108:361-73. 2012
    ....
  24. doi request reprint Phase I/II trial of hyperfractionated concomitant boost proton radiotherapy for supratentorial glioblastoma multiforme
    Masashi Mizumoto
    Proton Medical Research Center, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Int J Radiat Oncol Biol Phys 77:98-105. 2010
    ..To evaluate the safety and efficacy of postoperative hyperfractionated concomitant boost proton radiotherapy with nimustine hydrochloride for supratentorial glioblastoma multiforme (GBM)...
  25. ncbi request reprint Low peripheral lymphocyte count before focal radiotherapy plus concomitant temozolomide predicts severe lymphopenia during malignant glioma treatment
    Eiichi Ishikawa
    Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 50:638-44. 2010
    ..0321, Exp = 13.2). Lymphocyte counts before radiotherapy/TMZ of less than 1200/microl predict severe lymphopenia during radiotherapy/TMZ...
  26. ncbi request reprint Dynamic computed tomography myelography for the investigation of cervical degenerative disease
    Tomosato Yamazaki
    Department of Neurosurgery, Kensei General Hospital, Ibaraki, and Department of Neurosurgery, University of Tsukuba, Japan
    Neurol Med Chir (Tokyo) 46:210-5; discussion 215-6. 2006
    ....
  27. doi request reprint The optimization of fluorescence imaging of brain tumor tissue differentiated from brain edema--in vivo kinetic study of 5-aminolevulinic acid and talaporfin sodium
    Takao Tsurubuchi
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Japan
    Photodiagnosis Photodyn Ther 6:19-27. 2009
    ..We aimed to clarify the optimal timing for the fluorescence imaging of brain tumor tissue differentiated from brain edema after the administration of photosensitizers...
  28. ncbi request reprint Osteolytic lumbar discal cyst: case report
    Aiki Marushima
    Department of Neurosurgery, Kobari General Hospital, Noda, Chiba, Japan
    Neurol Med Chir (Tokyo) 48:363-6. 2008
    ..The cyst may have enlarged due to the inflow of the serous fluid from the water-containing degenerated disk...
  29. ncbi request reprint Glioma immunotherapy with combined autologous tumor cell and endothelial cell vaccine in vivo
    Noriaki Sakamoto
    Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 52:194-201. 2012
    ..Glioma immunotherapy with a combined vaccine prepared from tumor cells and endothelial cells might represent a new clinical strategy, as such combinations may theoretically affect both high-grade glioma cells and their environment...
  30. ncbi request reprint Long-term outcome of proton beam radiosurgery for arteriovenous malformations larger than 30 mm in diameter
    Yoshiro Ito
    Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Science, University of Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 51:624-9. 2011
    ..Thus, PB radiosurgery is a viable treatment option for AVMs ≥30 mm in diameter...
  31. ncbi request reprint Pilot study of the safety of starting administration of low-dose aspirin and cilostazol in acute ischemic stroke
    Keishi Fujita
    Department of Neurosurgery, Ibaraki Seinan Medical Center Hospital, Sashima, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 51:819-24. 2011
    ..6% and 75% at baseline and 3 months, respectively. No symptomatic intracranial hemorrhage or major extracranial hemorrhage occurred. These results suggest that administration of aspirin and cilostazol is safe for acute ischemic stroke...
  32. doi request reprint Cilostazol suppression of arterial intimal hyperplasia is associated with decreased expression of sialyl Lewis X homing receptors on mononuclear cells and E-selectin in endothelial cells
    Tomoji Takigawa
    Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Vasc Surg 55:506-16. 2012
    ..In this study, whether cilostazol inhibits neointimal formation and improves inflammatory actions by inhibiting sialyl Lewis X (SLX) expression on mononuclear cells and E-selectin expression on endothelial cells was evaluated...
  33. ncbi request reprint Navigation-guided endoscopic biopsy for intraparenchymal brain tumor
    Kyoji Tsuda
    Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 51:694-700. 2011
    ..The biopsy can be easily combined with both photodynamic diagnosis and intraoperative pathology, significantly improving the histological diagnostic yield...
  34. ncbi request reprint Long-term outcome of patients with intracranial germinoma
    Satoru Osuka
    Department of Neurosurgery, University Hospital of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
    J Neurooncol 83:71-9. 2007
    ..This study was to clarify the long-term subjective functional state and the therapeutic factors that may influence the outcome and ADL of patients with intracranial germinoma...
  35. doi request reprint Hypoxia-inducible factor 1α expression is a prognostic biomarker in patients with astrocytic tumors associated with necrosis on MR image
    Ryota Mashiko
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki
    J Neurooncol 102:43-50. 2011
    ..In conclusion, HIF-1α, but not HIF-2α, is a useful prognostic factor in astrocytic tumor associated with necrosis on MR images...
  36. ncbi request reprint In vivo gadolinium neutron capture therapy using a potentially effective compound (Gd-BOPTA)
    Akira Matsumura
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Anticancer Res 23:2451-6. 2003
    ..Therefore, we investigated whether Gd-BOPTA is an efficient agent for neutron capture therapy (NCT)...
  37. ncbi request reprint [Changes in 1H-MRS in glioma patients before and after irradiation: the significance of quantitative analysis of choline-containing compounds]
    Tomonori Isobe
    Department of Neurosurgery, Instituete of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    No Shinkei Geka 31:167-72. 2003
    ..Further long-term MRS study is needed to prove whether or not the decrease of the Cho value in the present study will change before recurrence at later stages...
  38. doi request reprint Time-course analysis of brain perfusion single photon emission computed tomography using a three-dimensional stereotactic region-of-interest template in patients with moyamoya disease
    Aiki Marushima
    Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    World Neurosurg 76:304-10. 2011
    ....
  39. ncbi request reprint Anti-angiogenic and immunomodulatory effect of the herbal medicine "Juzen-taiho-to" on malignant glioma
    Hiroshi Kamiyama
    Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
    Biol Pharm Bull 28:2111-6. 2005
    ..JTT would be useful as an adjuvant medicine for malignant gliomas through its enhancement of systemic immunological function and its anti-angiogenic action...
  40. doi request reprint Proton magnetic resonance spectroscopy findings of hemangioblastoma
    Tomonori Isobe
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Jpn J Radiol 28:318-21. 2010
    ..However, further investigations are required to establish the typical characteristics of proton MRS of hemangioblastoma...
  41. doi request reprint Absolute choline concentration measured by quantitative proton MR spectroscopy correlates with cell density in meningioma
    Qiang Yue
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba Science City, Ibaraki, 305 8575, Japan
    Neuroradiology 51:61-7. 2009
    ..This study was aimed to investigate the relationship between quantitative proton magnetic resonance spectroscopy (1H-MRS) and pathological changes in meningioma...
  42. ncbi request reprint Intracranial germinoma manifesting as cavernous sinus syndrome--case report
    Ai Muroi
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 52:754-6. 2012
    ..Chemotherapy and radiotherapy were administered, and the patient has been in complete remission for over 4 years...
  43. ncbi request reprint Valproic acid inhibits angiogenesis in vitro and glioma angiogenesis in vivo in the brain
    Satoru Osuka
    Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 52:186-93. 2012
    ..These data suggest a potential role for VPA as an adjuvant therapy for patients with malignant glioma...
  44. doi request reprint A subpopulation of endothelial progenitor cells with low aldehyde dehydrogenase activity attenuates acute ischemic brain injury in rats
    Kazuhiro Nakamura
    Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tennoudai 1 1 1, Tsukuba, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 418:87-92. 2012
    ..The transplantation of Alde-Low EPCs may represent a potential treatment strategy for acute cerebral infarction...
  45. pmc BMP-2 gene-fibronectin-apatite composite layer enhances bone formation
    Wei Zhang
    Nanosystem Research Institute NRI, National Institute of Advanced Industrial Science and Technology AIST, Higashi 1 1 1, Tsukuba, Ibaraki 305 8565, Japan
    J Biomed Sci 18:62. 2011
    ..We have developed an apatite composite layer including the bone morphogenetic protein-2 (BMP-2) gene and fibronectin (FB), and we evaluated its ability to induce bone formation...
  46. ncbi request reprint Apparently asymptomatic arachnoid cyst: postoperative improvement of subtle neuropsychological impediment -case report-
    Wakoto Matsuda
    Department of Neurosurgery, Ibaraki Prefectural Central Hospital, Ibaraki
    Neurol Med Chir (Tokyo) 50:430-3. 2010
    ..CBF study and neuropsychological evaluation by the WISC-R may be useful for selecting patients with apparently asymptomatic arachnoid cysts for surgery...
  47. doi request reprint Detection of failure of bevacizumab treatment for malignant glioma based on urinary matrix metalloproteinase activity
    Shingo Takano
    Department of Neurosurgery, Institute of Clinical Medicine, Tennodai, Tsukuba, Ibaraki, 305 8575, Japan
    Brain Tumor Pathol 27:89-94. 2010
    ..In addition, MMP9 has been proved as a molecule that facilitates its infiltrative behavior in vivo in the brain animal model...
  48. ncbi request reprint [Case report of germinoma with synchronous lesions in the thalamus and para lateral ventricle]
    Shingo Takano
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba City, Ibaragi 305 8575, Japan
    No Shinkei Geka 36:541-5. 2008
    ..Our experience suggests that a synchronous lesion at thalamus and para lateral ventricle seems to be due to subependymal infiltration other than CSF dissemination...
  49. doi request reprint Boron neutron capture therapy for glioblastoma
    Tetsuya Yamamoto
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Tenno dai 1 1 1, Tsukuba City, Ibaraki 305 8575, Japan
    Cancer Lett 262:143-52. 2008
    ....
  50. doi request reprint Oculomotor palsy treated by microvascular decompression
    Kensuke Suzuki
    Department of Neurosurgery, University of Tsukuba, Ibaraki 305 8575 Japan
    Surg Neurol 70:210-2. 2008
    ..Oculomotor palsy is well known to be due to diabetes mellitus, or aneurysmal compression, or cavernous sinus lesion. Only few reports presented that arterial compression was the reason for oculomotor palsy...
  51. doi request reprint Synthesis and evaluation of a novel liposome containing BPA-peptide conjugate for BNCT
    Makoto Shirakawa
    Department of Graduate School of Comprehensive Human Sciences, Faculty of Functional and Regulatory Medical Sciences, University of Tsukuba, Japan
    Appl Radiat Isot 67:S88-90. 2009
    ..In this study, lipid analog conjugated with HIV-TAT peptide (domain of human immunodeficiency virus TAT protein) and boronophenylalanine (BPA) was synthesized and successfully incorporated into liposomes...
  52. ncbi request reprint Clinical trial of autologous formalin-fixed tumor vaccine for glioblastoma multiforme patients
    Eiichi Ishikawa
    Department of Neurosurgery, Ibaraki Prefectural Central Hospital, Kasama, Ibaraki 309 1793, Japan
    Cancer Sci 98:1226-33. 2007
    ..Thus, the AFTV is safe and feasible, and could significantly improve the outcome of GBM. Further clinical investigations to confirm this are highly desirable...
  53. ncbi request reprint Mild encephalitis/encephalopathy with a reversible splenial lesion: evaluation by diffusion tensor imaging. Two case reports
    Satoru Osuka
    Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki
    Neurol Med Chir (Tokyo) 50:1118-22. 2010
    ..However, diffusion anisotropy of the lesions showed no remarkable abnormalities in the early or delayed phases. These results may indicate that white matter architecture is preserved in both early and delayed phases in MERS...
  54. doi request reprint PET pharmacokinetic analysis to estimate boron concentration in tumor and brain as a guide to plan BNCT for malignant cerebral glioma
    Tadashi Nariai
    Department of Neurosurgery, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Appl Radiat Isot 67:S348-50. 2009
    ..We report a positron emission tomography (PET) imaging method to estimate T/N ratio of tissue boron concentration based on pharmacokinetic analysis of amino acid probes...
  55. ncbi request reprint Angiogenesis and antiangiogenic therapy for malignant gliomas
    Shingo Takano
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
    Brain Tumor Pathol 21:69-73. 2004
    ..We conclude that malignant gliomas with high degrees of VEGF expression and vessel areas are good candidates for antiangiogenic therapy, especially that designed to inhibit VEGF expression...
  56. ncbi request reprint Encapsulated acute subdural hematoma mimicking acute epidural hematoma on computed tomography
    Shunichiro Miki
    Department of Neurosurgery, Ibaraki Seinan Medical Center Hospital, Sashima gun, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 52:826-8. 2012
    ..The possible mechanism in our case was that the re-bleeding dissected and flowed into the fibrinous single structural membrane, resulting in formation of the lentiform ASDH...
  57. doi request reprint Angiogenesis therapy for brain infarction using a slow-releasing drug delivery system for fibroblast growth factor 2
    Yoshiro Ito
    Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennnoudai 1 1 1, Tsukuba, Ibaraki 305 8575, Japan
    Biochem Biophys Res Commun 432:182-7. 2013
    ..Moreover, fluorescence immunohistochemistry showed that released FGF2 influenced microglia cells. This new FGF2 DDS involving an FGF2 apatite coating can prevent infarction of the penumbra through the multipotential effects of FGF2...
  58. ncbi request reprint Endovascular coiling as the first treatment strategy for ruptured pericallosal artery aneurysms: results, complications, and follow up
    Tomosato Yamazaki
    Department of Neurosurgery, Mito Medical Center, Japan
    Neurol Med Chir (Tokyo) 53:409-17. 2013
    ....
  59. doi request reprint Moyamoya disease: evaluation of postoperative revascularization using multiphase selective arterial spin labeling MRI
    Tsukasa Saida
    Department of Radiodiagnosis, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    J Comput Assist Tomogr 36:143-9. 2012
    ..The purpose of this study was to evaluate cerebral blood flow through the bypass in operated patients with Moyamoya disease using multiphase selective arterial spin labeling (ASL) technique...
  60. ncbi request reprint Meningioma associated with Werner syndrome--case report--
    Takao Tsurubuchi
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 48:470-3. 2008
    ..Patients with meningioma associated with Werner syndrome should be carefully followed up to detect the occurrence of other extracranial tumors such as sarcoma by brain MR imaging, echography, or body computed tomography...
  61. ncbi request reprint Quantification of cerebral metabolites in glioma patients with proton MR spectroscopy using T2 relaxation time correction
    Tomonori Isobe
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba Science City, Ibaraki, 305 8575 Japan
    Magn Reson Imaging 20:343-9. 2002
    ..001) and Cho (p < 0.01) concentration compared to low-grade gliomas. Low Cr concentration is the most reliable indicator of malignancy in glioma. Cho concentration did not correlate with malignancy in gliomas...
  62. ncbi request reprint Correlation between choline and MIB-1 index in human gliomas. A quantitative in proton MR spectroscopy study
    Akira Matsumura
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Clin Neurosci 12:416-20. 2005
    ..To clarify the significance of Cho level in gliomas, we evaluated the quantified Cho level using MRS and compared it with the proliferation activity as determined by MIB-1 immunoreactivity in the histological specimen...
  63. ncbi request reprint Impaired cognitive function due to cerebellar infarction and improvement after stent-assisted angioplasty for intracranial vertebral artery stenosis--case report
    Yoshiro Ito
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki
    Neurol Med Chir (Tokyo) 50:135-8. 2010
    ..In this case, cognitive dysfunction was reversed due to recovery of the cerebello-cerebral pathway...
  64. ncbi request reprint Perfusion-weighted magnetic resonance imaging of the spinal cord in cervical spondylotic myelopathy
    Kazuya Uemura
    Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 46:581-8. 2006
    ..The T0 index and TTP index showed no significant change in both groups. Reduction of MTT index may indicate improved perfusion of the spinal cord following surgery for cervical spondylotic myelopathy...
  65. ncbi request reprint Clinical characteristics and neuroimaging findings in 12 cases of recurrent glioblastoma with communicating hydrocephalus
    Kuniyuki Onuma
    Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 53:474-81. 2013
    ....
  66. doi request reprint Bioactive coils cause headache and fever after endovascular treatment of intracranial aneurysms
    Tomoji Takigawa
    Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Headache 52:312-21. 2012
    ..Based on our encounters with patients who have been treated for unruptured intracranial aneurysms by endovascular coil embolization using bioactive coils, we observed that such patients often present with headaches and fever...
  67. doi request reprint Delayed cyst formation after gamma knife radiosurgery for brain metastases
    Eiichi Ishikawa
    Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Neurosurgery 65:689-94; discussion 694-5. 2009
    ..Conversely, we recently experienced patients with delayed cyst formation (DCF) several years after GKRS, a complication not previously reported. Herein we assessed the frequency and characteristics of DCF after GKRS for METs...
  68. pmc Navigation-guided endoscopic biopsy for pathological diagnosis for intraparenchymal pure germinoma near the ventricular trigone
    Kuniyuki Onuma
    Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Surg Neurol Int 3:9. 2012
    ..The authors report a case of intraparenchymal germinoma pathologically diagnosed using navigation-guided endoscopic biopsy...
  69. doi request reprint Selective arterial embolization with n-butyl cyanoacrylate in the treatment of aneursymal bone cyst of the thoracic vertebra: a case report
    Aiki Marushima
    Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Spine (Phila Pa 1976) 34:E230-4. 2009
    ..A case report of aneurysmal bone cyst of the mobile spine...
  70. ncbi request reprint Persistent primitive olfactory artery aneurysm
    Tetsuya Yamamoto
    Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 49:303-5. 2009
    ..The aneurysm was located at this characteristic acute angle. The persistent POA aneurysm associated with an anterior communicating artery aneurysm with wide neck was successfully treated by clipping surgery...
  71. ncbi request reprint Non-invasive quantification of lactate by proton MR spectroscopy and its clinical applications
    Akira Matsumura
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba Science City, Ibaraki, 305 8575, Japan
    Clin Neurol Neurosurg 107:379-84. 2005
    ..Moreover, this technique enables lactate quantification in cases (e.g. tumor) where lipid peak is overlapped with the lactate peak at short echo times...
  72. ncbi request reprint Enhancement of sodium borocaptate (BSH) uptake by tumor cells induced by glutathione depletion and its radiobiological effect
    Fumiyo Yoshida
    University of Tsukuba, Graduate School of Comprehensive Human Sciences, Functional and Regulatory Medical Sciences, Tennodai 1 1 1, Tsukuba, Ibaraki 305 8575, Japan
    Cancer Lett 215:61-7. 2004
    ..These findings suggested that modulation of GSH enhanced the effect of B (n, alpha) reaction and the protective effect of secondary gamma-ray in BNCT...
  73. ncbi request reprint Characterization of neutron beams for boron neutron capture therapy: in-air radiobiological dosimetry
    Tetsuya Yamamoto
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan
    Radiat Res 160:70-6. 2003
    ....
  74. doi request reprint Detection of IDH1 mutation in human gliomas: comparison of immunohistochemistry and sequencing
    Shingo Takano
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
    Brain Tumor Pathol 28:115-23. 2011
    ..Therefore, IMab-1 is likely to be useful for the diagnosis of mutation-bearing gliomas and for determining the treatment strategy of grade III gliomas...
  75. ncbi request reprint [Granular cell tumor of the neurohypophysis observed with hypoglycemic attack]
    Ryotaro Suzuki
    Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba City, Ibaraki 305 8575, Japan
    No Shinkei Geka 40:723-8. 2012
    ..The authors report a case of a 30-year-old man with GCT presenting with hypoglycemic attack. Hypoglycemic attack could be due to dysfunction of the hypothalamus and one of the important symptoms of GCT...
  76. ncbi request reprint Vernet's syndrome caused by large mycotic aneurysm of the extracranial internal carotid artery after acute otitis media--case report
    Mizuki Amano
    Department of General Medicine, Ibaraki Prefectural Central Hospital, Kasama, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 50:45-8. 2010
    ..Extracranial ICA aneurysms due to focal infection should be considered in the differential diagnosis of lower cranial nerve palsy, although the incidence is thought to be very low...
  77. doi request reprint A useful side-hole on a guiding catheter for transvenous embolization of a transverse-sigmoid sinus dural arteriovenous fistula
    Wataro Tsuruta
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    Neurosurgery 63:ONSE91-2; discussion ONSE92. 2008
    ..To report the usefulness of a side-hole on a guiding catheter for transvenous embolization of transverse-sigmoid sinus (TSS) dural arteriovenous fistulae (DAVF) by a contralateral approach with a reversed Y-shaped confluence...
  78. ncbi request reprint Reversible holocord edema associated with intramedullary spinal abscess secondary to an infected dermoid cyst
    Takao Tsurubuchi
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Pediatr Neurosurg 37:282-6. 2002
    ..The change was considered to represent reversible inflammatory changes, as there was no neurological deficit found at the cervical level and it resolved after surgery and medical treatment. The pathomechanism is discussed herein...
  79. ncbi request reprint Primary cerebellar pilocytic astrocytoma with anaplastic features in a patient with neurofibromatosis type 1 - case report -
    Kyoji Tsuda
    Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 51:315-8. 2011
    ..In the present case, the tumor histology corresponded to this designation. The present case indicates that PAs with anaplastic features can occur in patients with NF-1...
  80. doi request reprint Cystic neurohypophysial germinoma associated with moyamoya disease
    Yasushi Shibata
    Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Neurol Sci 31:189-92. 2010
    ..In the management of such cases, physicians should be aware of the symptoms, course, and natural history of both diseases and the effects and side effects of each type of therapy...
  81. doi request reprint Application of liposomes incorporating doxorubicin with sialyl Lewis X to prevent stenosis after rat carotid artery injury
    Wataro Tsuruta
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Biomaterials 30:118-25. 2009
    ..These results demonstrate that an active targeting drug delivery system utilizing Dox-Lipo-SLX effectively prevents stenosis after angioplasty...
  82. ncbi request reprint [Massive subarachnoid hemorrhage and intraventricular hemorrhage after transsphenoidal surgery of pituitary adenoma: a case report]
    Yoshiro Ito
    Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 2 1 1 Amakubo, Tsukuba City, Ibaraki 305 8576, Japan
    No Shinkei Geka 37:887-92. 2009
    ..Here, we report a case of delayed and massive subarachnoid hemorrhage and intraventricular hemorrhage after transsphenoidal surgery for a suprasellar pituitary adenoma...
  83. ncbi request reprint Acquired hemophilia first manifesting as life-threatening intracranial hemorrhage: case report
    Ryota Mashiko
    Department of Neurosurgery, Kitaibaraki Municipal General Hospital, Kitaibaraki, Ibaraki, Japan
    Neurol Med Chir (Tokyo) 49:93-5. 2009
    ..Acquired hemophilia may cause life-threatening hemorrhage, and should be considered in patients with intracranial hemorrhages associated with unexplained prolongation of APTT...
  84. ncbi request reprint Endoscopic observation of pathophysiology of ventricular diverticulum
    Satoru Osuka
    Department of Neurosurgery, University Hospital of Tsukuba, Tsukuba, Japan
    Childs Nerv Syst 23:897-900. 2007
    ..We diagnosed this cystic lesion as a unique subtype of advanced VD mimicking spontaneous ventriculostomy. Endoscopic observation of the cyst was very useful for accurate diagnosis and safe treatment...
  85. ncbi request reprint Advanced Chiari malformation type I with marked spinal cord atrophy. Case report
    Yoshiro Ito
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    J Neurosurg Spine 3:324-7. 2005
    ..These procedures resulted in remarkable neurological improvement, even after 40 years of clinical progression. Spinal cord atrophy may be caused by chronic pressure of entrapped cerebrospinal fluid in the spinal canal...
  86. ncbi request reprint Excision of juvenile pilocytic astrocytoma of the midbrain after radiotherapy
    Koji Tsuboi
    Department of Neurosurgery, Doctoral Program in Functional and Regulatory Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Pediatr Neurosurg 42:311-5. 2006
    ..This case study shows that initial excision may be appropriate for some low-grade focal lesions in the midbrain when the histological diagnosis and consent have been obtained...
  87. ncbi request reprint [Charged particle therapy for brain tumors]
    Akira Matsumura
    Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    No Shinkei Geka 33:953-62. 2005
  88. doi request reprint Epileptogenic glioma in a 4-year-old child: a case report
    Ai Muroi
    Department of Neurosurgery, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki, 305 8575, Japan
    Brain Tumor Pathol 27:127-31. 2010
    ..The pathological diagnosis was epileptogenic glioma (grade I) composed of glial progenitor cells. The postoperative course has been uneventful with good seizure control for 3 years...
  89. ncbi request reprint ANCA-associated vasculitis (AAV) causing bilateral cerebral infarction and subsequent intracerebral hemorrhage without renal and respiratory dysfunction
    Yoshiro Ito
    Department of Neurosurgery, Kensei General Hospital, and Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, Japan
    J Neurol Sci 240:99-101. 2006
    ..Despite undergoing steroid pulse therapy, the patient died from the fatal cerebral hemorrhage. The clinical course of AAV is rapid progressive. In cases of atypical cerebrovascular disease, the possibility of ANCA should be investigated...