Affiliation: University of Tsukuba
- The inheritance of histone modifications depends upon the location in the chromosome in Saccharomyces cerevisiaeHiroshi Masumoto
Faculty of Life and Environmental Sciences, Initiative for the Promotion of Young Scientists Independent Research, University of Tsukuba, Tsukuba, Japan
PLoS ONE 6:e28980. 2011..Thus, a conservative distribution model most accurately explains the inheritance of histone modifications because the location of histones within euchromatin or heterochromatin determines which histone modifications are introduced...
- A reduction in age-enhanced gluconeogenesis extends lifespanMayumi Hachinohe
National Food Research Institute, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan
PLoS ONE 8:e54011. 2013..Furthermore, the tdh2 gene deletion can extend the replicative lifespan in a CR pathway-dependent manner. These findings demonstrate that the repression of enhanced gluconeogenesis effectively extends the cellular lifespan...
- Hst3 and Hst4 histone deacetylases regulate replicative lifespan by preventing genome instability in Saccharomyces cerevisiaeMayumi Hachinohe
Graduate School of Life and Environmental Sciences, Initiative for the Promotion of Young Scientists Independent Research, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
Genes Cells 16:467-77. 2011..Our results suggest that Hst3 and Hst4 regulate replicative lifespan through their ability to deacetylate histone H3-K56 to minimize genomic instability...
- Construction of multidrug-sensitive yeast with high sporulation efficiencyTakumi Chinen
Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennodai, Tsukuba, Japan
Biosci Biotechnol Biochem 75:1588-93. 2011..12geneΔ0HSR is a useful tool for chemical biology, not only in chemical screening but in target identification and verification of bioactive compounds...