Y Maru

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi An oncogenic form of the Flt-1 kinase has a tubulogenic potential in a sinusoidal endothelial cell line
    Y Maru
    Department of Genetics, Institute of Medical Science, University of Tokyo, Japan
    Eur J Cell Biol 79:130-43. 2000
  2. ncbi TFIIH functions are altered by the P210BCR-ABL oncoprotein produced on the Philadelphia chromosome
    Y Maru
    Department of Genetics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, 108 0071, Tokyo, Japan
    Mutat Res 483:83-8. 2001
  3. ncbi Molecular biology of chronic myeloid leukemia
    Y Maru
    Department of Genetics, Institute of Medical Science, University of Tokyo, Japan
    Int J Hematol 73:308-22. 2001
  4. ncbi BCR binds to the xeroderma pigmentosum group B protein
    Y Maru
    Department of Genetics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 0071, Japan
    Biochem Biophys Res Commun 260:309-12. 1999
  5. ncbi The tubulogenic activity associated with an activated form of Flt-1 kinase is dependent on focal adhesion kinase
    Y Maru
    Department of Genetics, Institute of Medical Science, University of Tokyo, Japan
    Biochim Biophys Acta 1540:147-53. 2001
  6. ncbi The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein
    N Takeda
    Department of Genetics, Institute of Medical Science, University of Tokyo, Tokyo 108, Japan
    Proc Natl Acad Sci U S A 96:203-7. 1999
  7. ncbi Virally activated Ras cooperates with integrin to induce tubulogenesis in sinusoidal endothelial cell lines
    Y Maru
    Department of Genetics, Institute of Medical Science, University of Tokyo, Japan
    J Cell Physiol 176:223-34. 1998
  8. ncbi The Dbl homology domain of BCR is not a simple spacer in P210BCR-ABL of the Philadelphia chromosome
    Y Kin
    Department of Genetics, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-0071, Japan
    J Biol Chem 276:39462-8. 2001
  9. ncbi Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS
    Y Maru
    Department of Genetics, University of Tokyo, Japan
    Mol Cell Biol 15:835-42. 1995
  10. ncbi Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis
    S Hiratsuka
    Department of Genetics, Institute of Medical Science, University of Tokyo, Japan
    Cancer Res 61:1207-13. 2001

Collaborators

Detail Information

Publications17

  1. ncbi An oncogenic form of the Flt-1 kinase has a tubulogenic potential in a sinusoidal endothelial cell line
    Y Maru
    Department of Genetics, Institute of Medical Science, University of Tokyo, Japan
    Eur J Cell Biol 79:130-43. 2000
    ..We suppose that matrix ligand-induced integrin signals cooperate with a low level of Flt-1 kinase activity to promote tubulogenic behaviors of endothelial cells in this system...
  2. ncbi TFIIH functions are altered by the P210BCR-ABL oncoprotein produced on the Philadelphia chromosome
    Y Maru
    Department of Genetics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, 108 0071, Tokyo, Japan
    Mutat Res 483:83-8. 2001
    ....
  3. ncbi Molecular biology of chronic myeloid leukemia
    Y Maru
    Department of Genetics, Institute of Medical Science, University of Tokyo, Japan
    Int J Hematol 73:308-22. 2001
    ..The aim of this review is to integrate molecular and biological information on BCR, ABL, and BCR-ABL and to focus on how signaling from those molecules mirrors the biological phenotypes of chronic myeloid leukemia...
  4. ncbi BCR binds to the xeroderma pigmentosum group B protein
    Y Maru
    Department of Genetics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 0071, Japan
    Biochem Biophys Res Commun 260:309-12. 1999
    ..GST-XPB(1-782) was largely in the nucleus and bound to p62 and BCR. Although the biological significance of the binding remains to be uncovered, BCR binds to the XPB/p62 complex...
  5. ncbi The tubulogenic activity associated with an activated form of Flt-1 kinase is dependent on focal adhesion kinase
    Y Maru
    Department of Genetics, Institute of Medical Science, University of Tokyo, Japan
    Biochim Biophys Acta 1540:147-53. 2001
    ....
  6. ncbi The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein
    N Takeda
    Department of Genetics, Institute of Medical Science, University of Tokyo, Tokyo 108, Japan
    Proc Natl Acad Sci U S A 96:203-7. 1999
    ..The persistent dysfunction of XPB may in part underlie genomic instability in blastic crisis...
  7. ncbi Virally activated Ras cooperates with integrin to induce tubulogenesis in sinusoidal endothelial cell lines
    Y Maru
    Department of Genetics, Institute of Medical Science, University of Tokyo, Japan
    J Cell Physiol 176:223-34. 1998
    ..These data suggest that the integrin-mediated Ras signals may be necessary but are not sufficient for tubulogenesis and that an artificial expression of v-Ras might substitute for the second signal required in this system...
  8. ncbi The Dbl homology domain of BCR is not a simple spacer in P210BCR-ABL of the Philadelphia chromosome
    Y Kin
    Department of Genetics, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-0071, Japan
    J Biol Chem 276:39462-8. 2001
    ..Although functions of the DH domain remain to be discovered, we propose that the DH domain makes positive contributions to P210BCR-ABL...
  9. ncbi Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS
    Y Maru
    Department of Genetics, University of Tokyo, Japan
    Mol Cell Biol 15:835-42. 1995
    ..These data provide evidence that BCR couples the cytoplasmic protein-tyrosine kinase and RAS signaling pathways...
  10. ncbi Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis
    S Hiratsuka
    Department of Genetics, Institute of Medical Science, University of Tokyo, Japan
    Cancer Res 61:1207-13. 2001
    ..Thus, Flt-1 has a dual function in angiogenesis, acting in a positive or negative manner in different biological conditions...
  11. ncbi Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion
    Y Itoh
    Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
    EMBO J 20:4782-93. 2001
    ..These findings elucidate a new function of the PEX domain: regulating MT1-MMP activity on the cell surface, which accelerates cellular invasiveness in the tissue...
  12. ncbi Inhibition of protein kinase C delta has negative effect on anchorage-independent growth of BCR-ABL-transformed Rat1 cells
    Y Kin
    Department of Genetics, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108, Tokyo, Japan
    Leuk Res 25:821-5. 2001
    ..Although overexpression of wild type PKC delta did not enhance soft agar colony number by BCR-ABL-transformed Rat1 cells, that of dominant-negative delta isoform reduced it by approximately 40%...
  13. ncbi [Experimental systems in CML biology]
    Y Maru
    Department of Genetics, Institute of Medical Science, University of Tokyo
    Nippon Rinsho 59:2322-8. 2001
    ..NOD/SCID transplantation model and conditional transgenic model may be the current best animal system by which to investigate cell dynamics in the most strict and natural circumstances...
  14. ncbi Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein
    H Toyoshima
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 90:5404-8. 1993
    ..Our results suggest that the LTK gene produces not only the putative receptor tyrosine kinase for unknown ligand but also multiple protein products that may have different functions...
  15. ncbi A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome
    H Hirai
    Nature 327:430-2. 1987
    ..Our observation of the mutation at codon 13 in leukaemic cell DNAs from all three cases suggests that activation of the N-ras gene is important in the development of leukaemia in some MDS cases...
  16. ncbi BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner
    A M Pendergast
    Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024 1570
    Cell 66:161-71. 1991
    ..These findings extend the range of potential SH2-protein interactions in growth control pathways and suggest a function for SH2 domains in the activation of the BCR-ABL oncogene as well as a role for BCR in cellular signaling pathways...
  17. ncbi The BCR gene encodes a novel serine/threonine kinase activity within a single exon
    Y Maru
    Howard Hughes Medical Institute, University of California, Los Angeles 90024 1570
    Cell 67:459-68. 1991
    ....