Tatsuya Maeda

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Stress granules: The last refuge of TORC1?
    Terunao Takahara
    Institute of Molecular and Cellular Biosciences The University of Tokyo Tokyo, Japan
    Cell Cycle 11:3707-8. 2012
  2. doi request reprint The signaling mechanism of ambient pH sensing and adaptation in yeast and fungi
    Tatsuya Maeda
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    FEBS J 279:1407-13. 2012
  3. pmc Sphingolipids regulate the yeast high-osmolarity glycerol response pathway
    Mirai Tanigawa
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Mol Cell Biol 32:2861-70. 2012
  4. pmc Pho85 kinase, a cyclin-dependent kinase, regulates nuclear accumulation of the Rim101 transcription factor in the stress response of Saccharomyces cerevisiae
    Masafumi Nishizawa
    Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
    Eukaryot Cell 9:943-51. 2010
  5. doi request reprint TORC1 of fission yeast is rapamycin-sensitive
    Terunao Takahara
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Genes Cells 17:698-708. 2012
  6. doi request reprint Transient sequestration of TORC1 into stress granules during heat stress
    Terunao Takahara
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell 47:242-52. 2012
  7. ncbi request reprint Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region
    Terunao Takahara
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 281:28605-14. 2006
  8. doi request reprint Isolation of hyperactive mutants of mammalian target of rapamycin
    Yoichiro Ohne
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    J Biol Chem 283:31861-70. 2008
  9. pmc Endocytosis of the aspartic acid/glutamic acid transporter Dip5 is triggered by substrate-dependent recruitment of the Rsp5 ubiquitin ligase via the arrestin-like protein Aly2
    Riko Hatakeyama
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Mol Cell Biol 30:5598-607. 2010
  10. ncbi request reprint Evaluation of mTOR function by a gain-of-function approach
    Yoichiro Ohne
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Cell Cycle 8:573-9. 2009

Collaborators

Detail Information

Publications14

  1. pmc Stress granules: The last refuge of TORC1?
    Terunao Takahara
    Institute of Molecular and Cellular Biosciences The University of Tokyo Tokyo, Japan
    Cell Cycle 11:3707-8. 2012
    ..Comment on: Takahara T, et al. Mol Cell 2012; 47:242-52...
  2. doi request reprint The signaling mechanism of ambient pH sensing and adaptation in yeast and fungi
    Tatsuya Maeda
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    FEBS J 279:1407-13. 2012
    ..Since the proteolytic complex is thought to be formed and activated on a platform of a multimerized ESCRT-III component Snf7, the organization, regulation and function of this pathway are dependent on the function of ESCRT complexes...
  3. pmc Sphingolipids regulate the yeast high-osmolarity glycerol response pathway
    Mirai Tanigawa
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Mol Cell Biol 32:2861-70. 2012
    ..These observations reveal the sphingolipid-mediated regulation of the osmosensing machinery of the HOG pathway...
  4. pmc Pho85 kinase, a cyclin-dependent kinase, regulates nuclear accumulation of the Rim101 transcription factor in the stress response of Saccharomyces cerevisiae
    Masafumi Nishizawa
    Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
    Eukaryot Cell 9:943-51. 2010
    ..These findings illustrate novel roles for the regulators of the PHO system when yeast cells cope with various environmental stresses potentially threatening their survival...
  5. doi request reprint TORC1 of fission yeast is rapamycin-sensitive
    Terunao Takahara
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Genes Cells 17:698-708. 2012
    ..These results indicate that rapamycin does inhibit TORC1 in S. pombe, but the inhibition is not sufficient to cause a growth defect. These findings establish a universal action of rapamycin on TORC1 inhibition...
  6. doi request reprint Transient sequestration of TORC1 into stress granules during heat stress
    Terunao Takahara
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell 47:242-52. 2012
    ..Furthermore, this mechanism contributes to reduction of heat-induced mutations. Thus, TORC1 signaling is coupled to heat-induced SGs to protect cells from DNA damage...
  7. ncbi request reprint Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region
    Terunao Takahara
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 281:28605-14. 2006
    ..In addition, Saccharomyces cerevisiae TOR proteins Tor1p and Tor2p also exist as homomultimers. These results suggest that TOR multimerization is a conserved mechanism for TOR functioning...
  8. doi request reprint Isolation of hyperactive mutants of mammalian target of rapamycin
    Yoichiro Ohne
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    J Biol Chem 283:31861-70. 2008
    ..This hyperactive mTOR mutant will be a valuable tool for establishing physiological consequences of mTOR activation in cells as well as in organisms...
  9. pmc Endocytosis of the aspartic acid/glutamic acid transporter Dip5 is triggered by substrate-dependent recruitment of the Rsp5 ubiquitin ligase via the arrestin-like protein Aly2
    Riko Hatakeyama
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Mol Cell Biol 30:5598-607. 2010
    ..Importantly, the interaction between Aly2 and Dip5 is accelerated in response to elevated aspartic acid availability. This result indicates that the regulation of Dip5 endocytosis is accomplished by dynamic recruitment of Rsp5 via Aly2...
  10. ncbi request reprint Evaluation of mTOR function by a gain-of-function approach
    Yoichiro Ohne
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Cell Cycle 8:573-9. 2009
    ..Hyperactive mTOR mutants are thus valuable tools for analysis of the activation mechanism as well as the in vivo function of mTOR...
  11. pmc Constitutive activation of the pH-responsive Rim101 pathway in yeast mutants defective in late steps of the MVB/ESCRT pathway
    Michio Hayashi
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell Biol 25:9478-90. 2005
    ..Based on extensive epistasis analysis between pathway-activating and -inactivating mutations, a model for architecture and regulation of the Rim101 pathway is proposed...
  12. doi request reprint Evolutionarily conserved regulation of TOR signalling
    Terunao Takahara
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    J Biochem 154:1-10. 2013
    ..In this review, we briefly summarize the current understanding of the evolutionarily conserved TOR signalling from upstream regulators to downstream events. ..
  13. pmc Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy
    Koichi Ojima
    Calpain Project, The Tokyo Metropolitan Institute of Medical Science Rinshoken, Tokyo, Japan
    J Clin Invest 120:2672-83. 2010
    ..Furthermore, our data provide direct evidence that loss of p94 protease activity can result in LGMD2A and molecular insight into how this could occur...
  14. pmc Phosphorelay-regulated degradation of the yeast Ssk1p response regulator by the ubiquitin-proteasome system
    Naoto Sato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell Biol 23:6662-71. 2003
    ..Our results indicate that unphosphorylated Ssk1p is selectively degraded by the Ubc7p-dependent ubiquitin-proteasome system and that this mechanism downregulates the HOG pathway after the completion of the osmotic adaptation...