Shin Maeda

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression
    Shin Maeda
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatology 50:1851-60. 2009
  2. ncbi Essential roles of high-mobility group box 1 in the development of murine colitis and colitis-associated cancer
    Shin Maeda
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1 6 1 Marunouchi, Chiyoda ku, Tokyo 100 0005, Japan
    Biochem Biophys Res Commun 360:394-400. 2007
  3. ncbi Pathogenesis of Helicobacter pylori infection
    Shin Maeda
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1 6 1 Marunouchi, Chiyoda ku, 100 0005 Tokyo, Japan
    Helicobacter 12:10-4. 2007
  4. ncbi Inflammation and cancer: role of nuclear factor-kappaB activation
    Shin Maeda
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1 6 1 Marunouchi, Chiyoda ku, Tokyo 100 0005, Japan
    Cancer Sci 99:836-42. 2008
  5. ncbi Colon cancer-derived factors activate NF-κB in myeloid cells via TLR2 to link inflammation and tumorigenesis
    Shin Maeda
    Department of Gastroenterology, Yokohama City University, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    Mol Med Rep 4:1083-8. 2011
  6. ncbi Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses
    Yoku Hayakawa
    Department of Gastroenterology, University of Tokyo, Tokyo 113 8655, Japan
    Gastroenterology 138:1055-67.e1-4. 2010
  7. ncbi Gastric cancer risk according to the distribution of intestinal metaplasia and neutrophil infiltration
    Kosuke Sakitani
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 26:1570-5. 2011
  8. ncbi Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis
    Yoku Hayakawa
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 44:935-43. 2009
  9. ncbi Inhibitor of kappaB kinase beta regulates gastric carcinogenesis via interleukin-1alpha expression
    Kei Sakamoto
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan
    Gastroenterology 139:226-38.e6. 2010
  10. ncbi Activation of IkappaB kinase and NF-kappaB is essential for Helicobacter pylori-induced chronic gastritis in Mongolian gerbils
    Ayako Yanai
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1 6 1 Marunouchi, Tokyo 100 0005, Japan
    Infect Immun 76:781-7. 2008

Detail Information

Publications89

  1. ncbi Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression
    Shin Maeda
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatology 50:1851-60. 2009
    ..CONCLUSION: Collectively, these observations suggest that IKKbeta/NF-kappaB activation controls the development of liver metastasis by way of IL-6 expression and is a potential target for the development of antimetastatic drugs...
  2. ncbi Essential roles of high-mobility group box 1 in the development of murine colitis and colitis-associated cancer
    Shin Maeda
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1 6 1 Marunouchi, Chiyoda ku, Tokyo 100 0005, Japan
    Biochem Biophys Res Commun 360:394-400. 2007
    ..These observations suggest that HMGB1 is a potentially useful target for IBD treatment and the prevention of colitis-associated cancer...
  3. ncbi Pathogenesis of Helicobacter pylori infection
    Shin Maeda
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1 6 1 Marunouchi, Chiyoda ku, 100 0005 Tokyo, Japan
    Helicobacter 12:10-4. 2007
    ..pylori infection which is similar to that in humans and can be used to evaluate virulence factors including CagA, host responses, and environmental factors such as salt intake...
  4. ncbi Inflammation and cancer: role of nuclear factor-kappaB activation
    Shin Maeda
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1 6 1 Marunouchi, Chiyoda ku, Tokyo 100 0005, Japan
    Cancer Sci 99:836-42. 2008
    ....
  5. ncbi Colon cancer-derived factors activate NF-κB in myeloid cells via TLR2 to link inflammation and tumorigenesis
    Shin Maeda
    Department of Gastroenterology, Yokohama City University, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    Mol Med Rep 4:1083-8. 2011
    ..Taken together, colon cancer-derived factors induce the accumulation of macrophages and activate NF-κB through a TLR2-dependent mechanism, suggesting an important link between inflammation and tumor growth...
  6. ncbi Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses
    Yoku Hayakawa
    Department of Gastroenterology, University of Tokyo, Tokyo 113 8655, Japan
    Gastroenterology 138:1055-67.e1-4. 2010
    ..Apoptosis signal-regulating kinase 1 (ASK1) is a MAPK kinase kinase; little is known about the role of ASK1 in colonic disease. We assessed the involvement of ASK1 in the development of intestinal inflammation and CAC...
  7. ncbi Gastric cancer risk according to the distribution of intestinal metaplasia and neutrophil infiltration
    Kosuke Sakitani
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 26:1570-5. 2011
    ..We aimed to elucidate the association between gastric cancer risk and the distribution of precancerous lesions in the stomach by histological analyses...
  8. ncbi Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis
    Yoku Hayakawa
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 44:935-43. 2009
    ..This study investigated whether inhibitors of IKKbeta, which is a critical kinase for NF-kappaB activation, reduce colitis-associated tumorigenesis in mice...
  9. ncbi Inhibitor of kappaB kinase beta regulates gastric carcinogenesis via interleukin-1alpha expression
    Kei Sakamoto
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan
    Gastroenterology 139:226-38.e6. 2010
    ..Nuclear factor-kappaB (NF-kappaB) is an important transcription factor involved in various biological processes, including carcinogenesis. However, it is unknown whether NF-kappaB activation is involved in gastric carcinogenesis...
  10. ncbi Activation of IkappaB kinase and NF-kappaB is essential for Helicobacter pylori-induced chronic gastritis in Mongolian gerbils
    Ayako Yanai
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1 6 1 Marunouchi, Tokyo 100 0005, Japan
    Infect Immun 76:781-7. 2008
    ..pylori gastritis. Collectively, our data suggest that H. pylori-mediated gastric inflammation critically depends on the efficient recruitment and activation of macrophages, with sufficient NF-kappaB activation...
  11. ncbi c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice
    Wataru Shibata
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, Chiyoda ku, Tokyo, Japan
    Cancer Res 68:5031-9. 2008
    ..Taken together, JNK seems to be involved in both tumor initiation and promotion and may be an attractive target for the prevention of gastric carcinogenesis...
  12. ncbi Cutting edge: The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis
    Wataru Shibata
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1 6 1 Marunouchi, Chiyoda ku, Tokyo 100 0005, Japan
    J Immunol 179:2681-5. 2007
    ..These results indicate that an IKKbeta-targeted NF-kappaB blockade using the NBD peptide could be an attractive therapeutic approach for inflammatory bowel disease...
  13. ncbi Constitutive NF-kappaB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth
    Kei Sakamoto
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan
    Clin Cancer Res 15:2248-58. 2009
    ..Constitutive NF-kappaB activation has been noted in many tumors, including colorectal cancers. However, the precise role of this activation in colorectal cancer is unclear...
  14. ncbi Clinical relevance of Helicobacter pylori sabA genotype in Japanese clinical isolates
    Ayako Yanai
    Division of Gastroenterology, The Institute for Adult Diseases, Asahi Life Foundation, Chiyoda ku, Tokyo, Japan
    J Gastroenterol Hepatol 22:2228-32. 2007
    ..The aim of this study was to assess the relationship between the status of H. pylori sialic acid-binding adhesin (sabA) and the severity of gastric inflammation and diseases...
  15. ncbi The effect of Helicobacter pylori eradication on reducing the incidence of gastric cancer
    Keiji Ogura
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Clin Gastroenterol 42:279-83. 2008
    ..017) between the groups, but not for undifferentiated cancer (P=0.847). The results of the current study suggest that the eradication of H. pylori infection reduces the incidence of gastric cancer...
  16. ncbi Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation
    Kosuke Sakitani
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Infect Immun 80:3795-803. 2012
    ..We also found that NF-κB activation was decreased in H. pylori-infected IL-32-knockdown cells. These results suggest that IL-32 has important functions in the regulation of cytokine expression in H. pylori-infected gastric mucosa...
  17. ncbi Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer
    Yoku Hayakawa
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Sci 103:2181-5. 2012
    ..These results indicate that ASK1 inhibition prevents GC cell growth in vitro and in vivo, suggesting that ASK1 inhibitors can be potent therapeutic drugs for GC...
  18. ncbi Effect of sumatriptan on gastric emptying: a crossover study using the BreathID system
    Yasunari Sakamoto
    Gastroenterology Division, Yokohama City University Hospital, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    World J Gastroenterol 18:3415-9. 2012
    ..To determine the effect of oral sumatriptan on gastric emptying using a continuous ¹³C breath test (BreathID system)...
  19. ncbi NF-kappaB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection
    Wataru Shibata
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    World J Gastroenterol 11:6134-43. 2005
    ....
  20. ncbi Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation
    Hayato Nakagawa
    Department of Gastroenterology, University of Tokyo, Hongo, Bunkyo ku, Tokyo
    Gastroenterology 135:1311-21. 2008
    ..We tested the hypothesis that ASK1 was involved in APAP-induced JNK activation and liver injury...
  21. ncbi Relationship between nuclear factor-kappaB activation and virulence factors of Helicobacter pylori in Japanese clinical isolates
    Shin Maeda
    Department of Gastroenterology, University of Tokyo, Japan
    J Gastroenterol Hepatol 17:556-62. 2002
    ..The aim of the present study was to evaluate these candidates in nuclear factor (NF)-kappaBeta activation, which is a critical regulator of genes involved in inflammatory reactions...
  22. ncbi Functional variability of cagA gene in Japanese isolates of Helicobacter pylori
    Yoshihiro Hirata
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gene 343:165-72. 2004
    ..pylori induces distinct diseases on host...
  23. ncbi Sitafloxacin resistance in Helicobacter pylori isolates and sitafloxacin-based triple therapy as a third-line regimen in Japan
    Yoshihiro Hirata
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Antimicrob Agents 39:352-5. 2012
    ..These results suggest that STX could be active against most clinical H. pylori isolates and that STX-based triple therapy is a promising and safe third-line therapy...
  24. ncbi Investigation of the prevalence and number of aberrant crypt foci associated with human colorectal neoplasm
    Eiji Sakai
    Gastroenterology Division, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama, 236 0004 Japan
    Cancer Epidemiol Biomarkers Prev 20:1918-24. 2011
    ..We attempted to investigate the relationship between the presence of ACF and human colorectal carcinogenesis using a relatively large sample size...
  25. ncbi MyD88 and TNF receptor-associated factor 6 are critical signal transducers in Helicobacter pylori-infected human epithelial cells
    Yoshihiro Hirata
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Immunol 176:3796-803. 2006
    ..These results suggest that the cag pathogenicity island of H. pylori is a cell type-specific NF-kappaB activator. TAK1, TRAF6, and MyD88 are important signal transducers in H. pylori-infected human epithelial cells...
  26. ncbi Helicobacter pylori induces IkappaB kinase alpha nuclear translocation and chemokine production in gastric epithelial cells
    Yoshihiro Hirata
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Infect Immun 74:1452-61. 2006
    ..IKKalpha nuclear translocation induced by H. pylori is indispensable for appropriate inflammatory responses but not for antiapoptosis, which suggests a critical role for IKKalpha in gastritis development...
  27. ncbi Helicobacter pylori CagA protein activates serum response element-driven transcription independently of tyrosine phosphorylation
    Yoshihiro Hirata
    Department of Gastroenterology, University of Tokyo, Japan
    Gastroenterology 123:1962-71. 2002
    ..Here we identify a new role for CagA protein as an activator of host cell signaling...
  28. ncbi Anti-tumor activity of the proteasome inhibitor bortezomib in gastric cancer
    Wachiko Nakata
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Oncol 39:1529-36. 2011
    ..We also observed anti‑tumor effects of bortezomib in vivo. Bortezomib is a potential novel molecular targeting drug for the treatment of unresectable advanced gastric cancer...
  29. ncbi Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase
    Hayato Nakagawa
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatology 54:185-95. 2011
    ..This study provides new insight into the regulation of stress- activated MAPK signaling in hepatocarcinogenesis...
  30. ncbi Use of fusion imaging combining contrast-enhanced ultrasonography with a perflubutane-based contrast agent and contrast-enhanced computed tomography for the evaluation of percutaneous radiofrequency ablation of hypervascular hepatocellular carcinoma
    Kazushi Numata
    Gastroenterological Center, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama, Kanagawa 232 0024, Japan
    Eur J Radiol 81:2746-53. 2012
    ....
  31. ncbi [NF-kappaB and MAPK-signaling pathways contribute to the gene expression and host response induced by Helicobacter pylori infection]
    Wataru Shibata
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo
    Nippon Rinsho 63:132-7. 2005
  32. ncbi Efficacy and safety of faropenem in eradication therapy of Helicobacter pylori
    Keiji Ogura
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Helicobacter 12:618-22. 2007
    ..To seek a better regimen for eradication therapy, we assessed the sensitivity of clinical strains seen in Japan to faropenem and then evaluated the efficacy and safety of eradication therapy containing this antibiotic...
  33. ncbi Helicobacter pylori induces antiapoptosis through buclear factor-kappaB activation
    Ayako Yanai
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Infect Dis 188:1741-51. 2003
    ..pylori. In conclusion, H. pylori induces antiapoptosis through c-IAP2 transactivation following cagPAI-dependent NF-kappaB activation. The interaction of these stimuli may play a role in gastric carcinogenesis...
  34. ncbi A new non-invasive modality for recording sequential images and the pH of the small bowel
    Hiroshi Iida
    Yokohama City University School of Medicine, Yokohama, Japan
    Hepatogastroenterology 59:413-4. 2012
    ..The aim of this study was to investigate the relationship between small bowel disease and the small bowel pH, we designed a new modality, the 'pH capsule', to non-invasively record sequential images and the pH...
  35. ncbi Is hepatic arterial infusion chemotherapy effective treatment for advanced hepatocellular carcinoma resistant to transarterial chemoembolization?
    Hiroyuki Kirikoshi
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    World J Gastroenterol 18:1933-9. 2012
    ..To evaluate the effectiveness of hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma (HCC) resistant to transarterial chemoembolization (TACE)...
  36. ncbi Findings of multidetector row computed tomography of HCCs treated by HIFU ablation
    Hiroyuki Fukuda
    Gastroenterological Center, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama, Kanagawa 232 0024, Japan
    Eur J Radiol 81:e239-43. 2012
    ....
  37. ncbi Helicobacter pylori activates NF-kappaB via the alternative pathway in B lymphocytes
    Tomoya Ohmae
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan
    J Immunol 175:7162-9. 2005
    ..The effects on chemokine production and antiapoptosis mediated by H. pylori-induced processing of NF-kappaB2/p100 to p52 may drive lymphocytes to acquire malignant potential...
  38. ncbi Influence of Helicobacter pylori eradication on the management of type 2 diabetes
    Masao Akanuma
    Asahi Life Foundation, Tokyo, Japan
    Hepatogastroenterology 59:641-5. 2012
    ..In addition, the number of patients with type 2 diabetes is increasing worldwide. The aim of this study was to understand the influence of H. pylori eradication therapy on the management of type 2 diabetes...
  39. ncbi Therapeutic effect of c-Jun N-terminal kinase inhibition on pancreatic cancer
    Ryota Takahashi
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo
    Cancer Sci 104:337-44. 2013
    ..Angiogenesis was also decreased by JNK inhibition in vitro and in vivo. In conclusion, activation of JNK promotes development of pancreatic cancer, and JNK may be a potential therapeutic target for pancreatic cancer...
  40. ncbi Endoscopic ultrasonographic findings predict the risk of carcinoma in branch duct intraductal papillary mucinous neoplasms of the pancreas
    Noritoshi Kobayashi
    Gastroenterology Division, Yokohama City University Graduate School of Medicine, 3 9, Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Pancreatology 12:141-5. 2012
    ..The purpose of this study was to evaluate the preoperative diagnostic value of endoscopic ultrasonography (EUS) in differentiating low-risk and high-risk IPMNs...
  41. ncbi Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH
    Hiroshi Iida
    Yokohama City University School of Medicine, Yokohama, Japan
    BMC Gastroenterol 12:25. 2012
    ..The aim of our study was to comparatively investigate the inhibitory effect on gastric acid secretion of a single oral administration of omeprazole plus mosapride with that of omeprazole alone...
  42. ncbi Reduced expression of RAS protein activator like-1 in gastric cancer
    Motoko Seto
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Cancer 128:1293-302. 2011
    ..Our findings demonstrate that reduced RASAL1 expression, partly due to genetic and epigenetic changes, contributes to gastric carcinogenesis, and also re-emphasize the importance of RAS signaling in gastric cancer development...
  43. ncbi Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer
    Yoku Hayakawa
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Proc Natl Acad Sci U S A 108:780-5. 2011
    ..These results indicate an autoregulatory mechanism of ASK1 in the development of gastric cancer. Targeting this positive feedback loop, ASK1 may present a potential therapeutic target for the treatment of advanced gastric cancer...
  44. ncbi Effects of domperidone on gastric emptying: a crossover study using a continuous real-time 13C breath test (BreathID system)
    Yasunari Sakamoto
    Gastroenterology Division, Yokohama City University School of Medicine, Kanazawaku, Yokohama, Japan
    Hepatogastroenterology 58:637-41. 2011
    ..To determine the correlation between domperidone and gastric emptying using the continuous real time 13C breath-test (BreathID system), a novel non-invasive technique for measuring gastric emptying...
  45. ncbi Novel Lens culinaris agglutinin-reactive fraction of α-fetoprotein: a biomarker of hepatocellular carcinoma recurrence in patients with low α-fetoprotein concentrations
    Manabu Morimoto
    Gastroenterological Center, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    Int J Clin Oncol 17:373-9. 2012
    ..This cross-sectional study was conducted to evaluate the clinical significance of the sensitive AFP-L3% in determining HCC recurrence in patients with low total AFP concentrations...
  46. ncbi Eicosapentaenoic acid (EPA) efficacy for colorectal aberrant crypt foci (ACF): a double-blind randomized controlled trial
    Takuma Higurashi
    Division of Gastroenterology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    BMC Cancer 12:413. 2012
    ....
  47. ncbi Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway
    Yotaro Kudo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatol 55:1400-8. 2011
    ....
  48. ncbi Helicobacter pylori activates the proto-oncogene c-fos through SRE transactivation
    Yuzo Mitsuno
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 291:868-74. 2002
    ..pylori possessing intact cag PAI. SRE is required for the activation of c-fos by H. pylori. These results suggest a direct involvement of H. pylori infection in cellular proliferation, which may play a role in neoplastic transformation...
  49. ncbi Determining early gastric cancer lesions appropriate for endoscopic submucosal dissection trainees: a proposal related to curability
    Kingo Hirasawa
    Gastroenterological Center, Yokohama City University Medical Center Division of Gastroenterology, Yokohama, Japan
    Dig Endosc 24:143-7. 2012
    ..In addition, we suggest that this risk assessment chart is suitable for the pretreatment assessment of curability and the likelihood of successful en bloc resection...
  50. ncbi Risk assessment chart for curability of early gastric cancer with endoscopic submucosal dissection
    Kingo Hirasawa
    Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan
    Gastrointest Endosc 74:1268-75. 2011
    ..Endoscopic submucosal dissection (ESD) was introduced worldwide as a new treatment option for early gastric cancer, but curability prediction has not been evaluated on an individual basis...
  51. ncbi Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: an analysis based on gender differences
    Hayato Nakagawa
    Department of Gastroenterology, University of Tokyo, Tokyo 113 8655, Japan
    Int J Cancer 125:2264-9. 2009
    ..Measurement of serum IL-6 levels may provide useful information for predicting future HCC development in female chronic hepatitis C patients...
  52. ncbi Radiofrequency ablation combined with transarterial chemoembolization for subcapsular hepatocellular carcinoma: a prospective cohort study
    Manabu Morimoto
    Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama, Kanagawa 232 0024, Japan
    Eur J Radiol 82:497-503. 2013
    ....
  53. ncbi Peroxisome Proliferator-Activated Receptor Gamma Exacerbates Concanavalin A-Induced Liver Injury via Suppressing the Translocation of NF-κB into the Nucleus
    Yuji Ogawa
    Department of Gastroenterology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    PPAR Res 2012:940384. 2012
    ..In this study, we showed that PPARγ exacerbated Con A-induced liver injury via suppressing the translocation of NF-κB into the nucleus, thereby inhibiting the suppression of liver cell apoptosis...
  54. ncbi Risk factors for colonic diverticular hemorrhage: Japanese multicenter study
    Kaori Suzuki
    Department of Gastroenterology, Yokohama Rosai Hospital, Yokohama, Japan
    Digestion 85:261-5. 2012
    ..However, the exact cause of diverticular hemorrhage is not well understood. We investigated the risk factors for diverticular hemorrhage...
  55. ncbi Usefulness of US-CT 3D dual imaging for the planning and monitoring of hepatocellular carcinoma treatment using HIFU
    Hiroyuki Fukuda
    Gastroenterological Center, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama, Kanagawa 232 0024, Japan
    Eur J Radiol 80:e306-10. 2011
    ..We evaluated the safety and usefulness of high-intensity focused ultrasound (HIFU) assisted by ultrasound-computed tomography three-dimensional (US-CT 3D) dual imaging for the treatment of hepatocellular carcinoma (HCC)...
  56. ncbi Sitagliptin as a novel treatment agent for non-alcoholic Fatty liver disease patients with type 2 diabetes mellitus
    Tomoyuki Iwasaki
    Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Hepatogastroenterology 58:2103-5. 2011
    ..However, no effective drug therapy for NAFLD has been established yet. In the present study, we evaluated the efficacy of 4 months of treatment with sitagliptin in NAFLD patients with type 2 diabetes mellitus (DM)...
  57. ncbi The evaluation of putative virulence factors of Helicobacter pylori for gastroduodenal disease by use of a short-term Mongolian gerbil infection model
    Masao Akanuma
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Infect Dis 185:341-7. 2002
    ..The Mongolian gerbil model was useful for the screening of virulence determinants in vivo, which confirmed the importance of cag PAI while questioning that of HP0499...
  58. ncbi Mortality from gastric cancer in patients followed with upper gastrointestinal endoscopy
    Masako Ogura
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan
    Scand J Gastroenterol 43:574-80. 2008
    ..The aim of the study was to investigate if gastric cancer-related mortality can be reduced by regular endoscopy...
  59. ncbi Targeting NF-kappaB for colorectal cancer
    Kei Sakamoto
    Institute for Adult Diseases, Asahi Life Foundation, Division of Gastroenterology, 1 6 1 Marunouchi, Chiyoda ku, 100 0005 Tokyo, Japan
    Expert Opin Ther Targets 14:593-601. 2010
    ..The NF-kappaB signaling pathway plays critical roles in physiological and pathological processes, and the relationship between colon cancer development and NF-kappaB is becoming clear...
  60. ncbi Risk factors for esophageal variceal bleeding in patients with hepatocellular carcinoma
    Masao Akanuma
    Division of Gastroenterology, Department of Internal Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hepatogastroenterology 49:1039-44. 2002
    ..To evaluate the risk factors for esophageal variceal bleeding in patients with hepatocellular carcinoma...
  61. ncbi Semaphorin 4D, a lymphocyte semaphorin, enhances tumor cell motility through binding its receptor, plexinB1, in pancreatic cancer
    Shingo Kato
    Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Cancer Sci 102:2029-37. 2011
    ..Our findings provide new insight into possible prognostic biomarkers and therapeutic targets in PDAC patients...
  62. ncbi Endoscopic diagnosis of Barrett's esophagus
    Tomoyuki Akiyama
    Tomoyuki Akiyama, Shigeru Koyama, Department of Gastroenterology, Tokyo Metropolitan Hiroo Hospital, Tokyo 150 0013, Japan
    World J Gastroenterol 18:3477-8. 2012
    ..We suspect that the high prevalence of BE in our study may be due to the inclusion of ultrashort-segment BE, which defines BE with an affected mucosal length under 5 mm, in our positive results...
  63. ncbi Change of Gastric Emptying With Chewing Gum: Evaluation Using a Continuous Real-Time C Breath Test (BreathID System)
    Yasunari Sakamoto
    Gastroenterology Division, Yokohama City University School of Medicine, Yokohama, Japan
    J Neurogastroenterol Motil 17:174-9. 2011
    ..The aim of this study was to determine the correlation between chewing gum and gastric emptying using the continuous real time (13)C breath test (BreathID system)...
  64. ncbi Mosapride Accelerates the Delayed Gastric Emptying of High-Viscosity Liquids: A Crossover Study Using Continuous Real-Time C Breath Test (BreathID System)
    Yasunari Sakamoto
    Gastroenterology Division, Yokohama City University School of Medicine, Yokohama, Japan
    J Neurogastroenterol Motil 17:395-401. 2011
    ..The present study was conducted with the aim of determining whether high-viscosity liquid meals had any effect on the rate of gastric emptying and mosapride might accelerate the rate of gastric emptying of high-viscosity liquid meals...
  65. ncbi Non-bismuth quadruple therapy for first-line Helicobacter pylori eradication: A randomized study in Japan
    Ayako Yanai
    Ayako Yanai, Department of Gastroenterology, Toranomon Hospital Kajigaya, 1 3 1 Kajigaya, Takatsu ku, Kawasaki, Kanagawa 213 8587, Japan
    World J Gastrointest Pharmacol Ther 3:1-6. 2012
    ..To find the way to improve the eradication rate of first-line therapy in Japanese patients...
  66. ncbi Efficacy of fusion imaging combining sonography and hepatobiliary phase MRI with Gd-EOB-DTPA to detect small hepatocellular carcinoma
    Yosuke Kunishi
    Gastroenterological Center, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama, Kanagawa 232 0024, Japan
    AJR Am J Roentgenol 198:106-14. 2012
    ....
  67. ncbi Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
    Hideaki Ijichi
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 121:4106-17. 2011
    ..Further, our results suggest that inhibiting tumor-stromal interactions might be a promising therapeutic strategy for PDAC...
  68. ncbi Assessment of the risk factors for colonic diverticular hemorrhage
    Atsuo Yamada
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Dis Colon Rectum 51:116-20. 2008
    ..Studies about risk factors, other than nonsteroidal anti-inflammatory drugs, for colonic diverticular hemorrhage are limited. We conducted the present study to elucidate their significance as a risk factor...
  69. ncbi [Role of NF-kappaB activation in inflammation-associated carcinogenesis]
    Shin Maeda
    Division of Gastroenterology, The Institute for Adult Diseases, Asahi Life Foundation, 1-6-1 Marunouchi, Chiyoda-ku, Tokyo 100-0005, Japan
    Seikagaku 78:330-4. 2006
  70. ncbi Influence of pretreatment with H2 receptor antagonists on the cure rates of Helicobacter pylori eradication
    Chikako Tokoro
    Gastroenterology Division, Yokohama City University Hospital, Yokohama, Japan
    Med Sci Monit 17:CR235-40. 2011
    ..pylori eradication has not yet been studied. We compared the efficacy of eradication regimen (lansoprazole/amoxicillin/clarithromycin) in patients with H. pylori infection with or without H2RA pretreatment...
  71. ncbi [Helicobacter pylori virulence factors except CagA]
    Shin Maeda
    Department of Gastroenterology, University of Tokyo
    Nihon Rinsho 67:2251-6. 2009
    ..Signaling pathway via toll-like receptors(TLR) is also thought to be important especially in myeloid cells even though bioactivity of H. pylori LPS is reported to be weak compared with other bacteria such as E. coli...
  72. ncbi Clostridium difficile infection in patients with ulcerative colitis: investigations of risk factors and efficacy of antibiotics for steroid refractory patients
    Takashi Kaneko
    Inflammatory Bowel Disease Center, Yokohama City University Medical Center, Yokohama, Japan
    Clin Res Hepatol Gastroenterol 35:315-20. 2011
    ..Potentially, CDI can exacerbate UC. Therefore, knowledge on the prevalence of CDI should contribute to better management of UC patients...
  73. ncbi Solitary Peutz-Jeghers type hamartomatous polyps in the duodenum are not always associated with a low risk of cancer: two case reports
    Yusuke Sekino
    Gastroenterology Division, Yokohama City University School of Medicine, 3 9 Fukuura Kanazawa ku, Yokohama, 236 0004, Japan
    J Med Case Reports 5:240. 2011
    ..abstract:..
  74. ncbi Hydroxyurea suppresses HCV replication in humans: a Phase I trial of oral hydroxyurea in chronic hepatitis C patients
    Akito Nozaki
    Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan
    Antivir Ther 15:1179-83. 2010
    ..By using a recently developed genome-length HCV RNA replication reporter assay system, we found that hydroxyurea (HU), an inhibitor of DNA synthesis, inhibited HCV RNA replication...
  75. ncbi Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression
    Jun-Li Luo
    Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cancer Cell 6:297-305. 2004
    ..The latter response is TNFalpha-independent, but depends on another member of the TNF superfamily, TRAIL, whose receptor is induced in NF-kappaB-deficient cancer cells...
  76. ncbi Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis
    Toshiharu Sakurai
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Cancer Cell 14:156-65. 2008
    ..IL-1 alpha release by necrotic hepatocytes is therefore an important mediator of liver tumorigenesis...
  77. ncbi Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation
    Toshiharu Sakurai
    Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0723, La Jolla, CA 92093 0723, USA
    Proc Natl Acad Sci U S A 103:10544-51. 2006
    ....
  78. ncbi IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive MC 0723, La Jolla, California 92093, USA
    Cell 121:977-90. 2005
    ..IKKbeta, therefore, orchestrates inflammatory crosstalk between hepatocytes and hematopoietic-derived cells that promotes chemical hepatocarcinogenesis...
  79. ncbi Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 307:734-8. 2005
    ..These effects are linked to increased susceptibility to bacterial-induced intestinal inflammation and identify NOD2 as a positive regulator of NF-kappaB activation and IL-1beta secretion...
  80. ncbi Oncogene at last--c-Jun promotes liver cancer in mice
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cancer Cell 3:102-4. 2003
  81. ncbi IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA
    Immunity 19:725-37. 2003
    ..Thus, the antiapoptotic function of IKKbeta, which is most critical in situations that involve cell-bound TNFalpha, is mediated partially through attenuation of JNK activity...
  82. ncbi The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4
    Li Chung Hsu
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0636, USA
    Nature 428:341-5. 2004
    ..The pro-apoptotic actions of PKR are mediated both through inhibition of protein synthesis and activation of interferon response factor 3...
  83. ncbi The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice
    Alema Galijatovic
    Laboratory of Environmental Toxicology, Department of Pharmacology, University of California, San Diego, La Jolla 92093, USA
    J Biol Chem 279:23969-76. 2004
    ..Combined these results indicate that tissue-specific and developmental factors are controlling aryl hydrocarbon receptor-mediated induction of human CYP1A1...
  84. ncbi Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists
    Jin Mo Park
    Laboratory of Gene Regulation and Signal Transduction, Dept of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    J Exp Med 200:1647-55. 2004
    ..We also provide genetic evidence that ALO is required for induction of macrophage apoptosis in response to infection with live B. anthracis and that other CDC family members share the ability to activate TLR4...
  85. ncbi IKK-beta links inflammation to obesity-induced insulin resistance
    Melek C Arkan
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Med 11:191-8. 2005
    ..We suggest that inhibition of IKK-beta, especially in myeloid cells, may be used to treat insulin resistance...
  86. ncbi Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    Willscott E Naugler
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Cancer Center, University of California, San Diego, CA 93093, USA
    Science 317:121-4. 2007
    ..We propose that estrogen-mediated inhibition of IL-6 production by KCs reduces liver cancer risk in females, and these findings may be used to prevent HCC in males...
  87. ncbi Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    Hideaki Kamata
    Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 120:649-61. 2005
    ..Antioxidant treatment also prevents TNFalpha-mediated fulminant liver failure without affecting liver regeneration...
  88. ncbi I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss
    Maria Grazia Ruocco
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 201:1677-87. 2005
    ..IKKbeta also protects osteoclasts and their progenitors from tumor necrosis factor alpha-induced apoptosis, and its loss in hematopoietic cells prevents inflammation-induced bone loss...
  89. ncbi The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover
    Lufen Chang
    Division of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, City of Hope National Medical Center, 1500 E Duarte Road, KCRB 3009, Duarte, CA 91010, USA
    Cell 124:601-13. 2006
    ..Thus, JNK antagonizes NF-kappaB during TNFalpha signaling by promoting the proteasomal elimination of c-FLIP(L)...