S Maeda

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Detection of clarithromycin-resistant helicobacter pylori strains by a preferential homoduplex formation assay
    S Maeda
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    J Clin Microbiol 38:210-4. 2000
  2. ncbi H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells
    S Maeda
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gastroenterology 119:97-108. 2000
  3. ncbi cDNA microarray analysis of Helicobacter pylori-mediated alteration of gene expression in gastric cancer cells
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo, Bunkyo ku, 113 8655, Japan
    Biochem Biophys Res Commun 284:443-9. 2001
  4. ncbi Distinct mechanism of Helicobacter pylori-mediated NF-kappa B activation between gastric cancer cells and monocytic cells
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 276:44856-64. 2001
  5. ncbi Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori
    S Maeda
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gut 50:771-8. 2002
  6. ncbi Relationship between nuclear factor-kappaB activation and virulence factors of Helicobacter pylori in Japanese clinical isolates
    Shin Maeda
    Department of Gastroenterology, University of Tokyo, Japan
    J Gastroenterol Hepatol 17:556-62. 2002
  7. ncbi Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Pathol 55:286-93. 2002
  8. ncbi Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil
    K Ogura
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Exp Med 192:1601-10. 2000
  9. ncbi CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model
    W Shibata
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Pathol 210:306-14. 2006
  10. ncbi Helicobacter pylori activates the cyclin D1 gene through mitogen-activated protein kinase pathway in gastric cancer cells
    Y Hirata
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Infect Immun 69:3965-71. 2001

Collaborators

Detail Information

Publications81

  1. ncbi Detection of clarithromycin-resistant helicobacter pylori strains by a preferential homoduplex formation assay
    S Maeda
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    J Clin Microbiol 38:210-4. 2000
    ..1 mg/liter). Therefore, PHFA can detect clarithromycin-resistant H. pylori strains, even in patients with mixed infections with the wild type, that are not detectable by the agar dilution method...
  2. ncbi H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells
    S Maeda
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gastroenterology 119:97-108. 2000
    ..The aim of this study was to analyze the molecular mechanism responsible for H. pylori-mediated NF-kappaB activation on gastric cancer cells...
  3. ncbi cDNA microarray analysis of Helicobacter pylori-mediated alteration of gene expression in gastric cancer cells
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo, Bunkyo ku, 113 8655, Japan
    Biochem Biophys Res Commun 284:443-9. 2001
    ..Taken together, these results indicate the importance of microarray technology as a tool for analyzing the complex interplay between H. pylori and the host...
  4. ncbi Distinct mechanism of Helicobacter pylori-mediated NF-kappa B activation between gastric cancer cells and monocytic cells
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 276:44856-64. 2001
    ..pylori-induced NF-kappaB activation in epithelial cells is dependent on cag PAI and contact but does not involve CD14 and IRAK, whereas in macrophage/monocytic cells it is independent of cag PAI or contact but involves CD14 and TLR4...
  5. ncbi Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori
    S Maeda
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gut 50:771-8. 2002
    ..Although it is reported that Helicobacter pylori induces apoptosis on gastric epithelial cells, the mechanism remains unknown. Antiapoptotic effects generated by H pylori have not yet been evaluated...
  6. ncbi Relationship between nuclear factor-kappaB activation and virulence factors of Helicobacter pylori in Japanese clinical isolates
    Shin Maeda
    Department of Gastroenterology, University of Tokyo, Japan
    J Gastroenterol Hepatol 17:556-62. 2002
    ..The aim of the present study was to evaluate these candidates in nuclear factor (NF)-kappaBeta activation, which is a critical regulator of genes involved in inflammatory reactions...
  7. ncbi Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Pathol 55:286-93. 2002
    ..Although it is reported that Helicobacter pylori induces apoptosis on gastric epithelial cells, the mechanism remains unknown. Antiapoptotic effects generated by H pylori have not yet been evaluated...
  8. ncbi Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil
    K Ogura
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Exp Med 192:1601-10. 2000
    ..In conclusion, the knocking out of the cagE gene deprived wild-type H. pylori of the pathogenicity for gastritis and gastric ulcer, suggesting that the secretion system encoded by cag pathogenicity island genes plays an essential role...
  9. ncbi CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model
    W Shibata
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Pathol 210:306-14. 2006
    ..It is concluded that CagA protein may be essential for the induction of severe gastritis in the Mongolian gerbil model...
  10. ncbi Helicobacter pylori activates the cyclin D1 gene through mitogen-activated protein kinase pathway in gastric cancer cells
    Y Hirata
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Infect Immun 69:3965-71. 2001
    ..pylori activates cyclin D1 through the mitogen-activated protein kinase pathway and not through NF-kappaB activation in AGS cells. This activation of cyclin D1 is partly dependent on the cag pathogenicity island but not on vacA...
  11. ncbi Expression of vascular endothelial growth factor at the human gastric ulcer margin and in cultured gastric fibroblasts: a new angiogenic factor for gastric ulcer healing
    M Takahashi
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo ku, Japan
    Biochem Biophys Res Commun 234:493-8. 1997
    ..We further demonstrate the expression of VEGF by cultured human gastric fibroblasts which is enhanced by tumor necrosis factor-alpha. These data suggest that VEGF may play a role in angiogenesis in the process of gastric ulcer healing...
  12. ncbi Helicobacter pylori induced transactivation of SRE and AP-1 through the ERK signalling pathway in gastric cancer cells
    Y Mitsuno
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gut 49:18-22. 2001
    ..c-Fos is important for transactivation of AP-1 which has SRE in the promoter region. We conducted this study to confirm H pylori induced transactivation of these binding sites...
  13. ncbi Clarithromycin-based triple therapy for non-resistant Helicobacter pylori infection. How long should it be given?
    K Ogura
    Dept of Gastroenterology, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo 113 8655, Japan
    Scand J Gastroenterol 36:584-8. 2001
    ..The aim of this study is to assess the efficacy of clarithromycin-based triple therapy in patients infected exclusively with wild-type strains as determined by PCR-PHFA...
  14. ncbi Determination of Helicobacter pylori virulence by simple gene analysis of the cag pathogenicity island
    T Ikenoue
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Diagn Lab Immunol 8:181-6. 2001
    ..The cagE gene was a more accurate marker of an intact cag PAI than the cagA gene, and cagE seemed to be more useful in discriminating between H. pylori strains causing different rates of disease progression...
  15. ncbi Hepatitis C virus core protein activates nuclear factor kappa B-dependent signaling through tumor necrosis factor receptor-associated factor
    H Yoshida
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan
    J Biol Chem 276:16399-405. 2001
    ..In fact, HCV core protein activated interleukin-1beta promoter mainly through NF-kappaB pathway. Therefore, this function of HCV core protein may play an important role in the inflammatory reaction induced by this hepatotropic virus...
  16. ncbi Determination of the optimal cut-off value for the [13C]-urea breath test based on a Helicobacter pylori-specific polymerase chain reaction assay
    H Yoshida
    Department of Gastroenterology, University of Tokyo, Bunkyo, Japan
    J Gastroenterol Hepatol 15:155-60. 2000
    ..7% at 20 min had the longest distance, being separated by 3.16 SD from the two mean values. Using this cut-off value, the urea breath test showed 100% specificity and 98% sensitivity for the diagnosis of Helicobacter pylori infection...
  17. ncbi Suspected allergic reactions after vaccination in 85 dogs in Japan
    K Ohmori
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi Bunkyo-ku, Tokyo 113-8657, Japan
    Vet Rec 156:87-8. 2005
  18. ncbi Use of electron microscopic evaluation for the diagnosis of adrenal cortical carcinoma in fine needle aspiration cytology: a case report and review of the literature
    A M Liu
    Central Institute for Electron Microscopic Research, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Med Electron Microsc 34:190-7. 2001
    ..A diagnosis of primary adrenal cortical carcinoma with extensive metastases was finally demonstrated by autopsy. Retrospectively, the previous liver tumor was determined to be a metastatic lesion...
  19. ncbi Decreased immunoglobulin A concentrations in feces, duodenum, and peripheral blood mononuclear cells of dogs with inflammatory bowel disease
    S Maeda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Intern Med 27:47-55. 2013
    ..Although immunoglobulin A (IgA) plays a key role in regulating gut homeostasis, its role in canine inflammatory bowel disease (IBD) is unknown...
  20. ncbi Ultrasonographic evaluation of vincristine-induced gastric hypomotility and the prokinetic effect of mosapride in dogs
    A Tsukamoto
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Vet Intern Med 25:1461-4. 2011
    ..Vincristine induces gastrointestinal motility disorders in humans. Adverse gastrointestinal events are commonly observed in dogs receiving vincristine...
  21. ncbi A crucial role of sialidase Neu1 in hyaluronan receptor function of CD44 in T helper type 2-mediated airway inflammation of murine acute asthmatic model
    S Katoh
    Department of Cell Regulation, Faculty of Medicine, Kagawa University, Kanagawa, Japan
    Clin Exp Immunol 161:233-41. 2010
    ..Our observation suggests that Neu1 may be a target molecule for the treatment of asthma...
  22. ncbi Promoters of epithelialization induce expression of vascular endothelial growth factor in human gastric epithelial cells in primary culture
    M Takahashi
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    FEBS Lett 418:115-8. 1997
    ..HGF and EGF receptors were expressed by the cells, suggesting that regulation may be mediated through specific receptors...
  23. ncbi Expression and localization of basic fibroblast growth factor and its mRNA in solitary fibrous tumor
    X Li
    Department of Pathology, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 68:384-92. 2001
    ....
  24. ncbi MAGE-A protein and MAGE-A10 gene expressions in liver metastasis in patients with stomach cancer
    S Suzuki
    Department of Surgery, Tama Nagayama Hospital, Nippon Medical School, Tama, Tokyo, Japan
    Br J Cancer 99:350-6. 2008
    ..7% (P<0.0001). MAGE-A10 gene expression was associated with reduced survival duration. The results of this study suggest that MAGE-A10 is a possible target in active immunotherapy for advanced stomach cancer...
  25. ncbi Primary leiomyoma of the pancreas
    Y Nakamura
    Departments of Surgery, Tamanagayama Hospital of Nippon Medical School, Tama City, Tokyo, Japan
    Int J Pancreatol 28:235-8. 2000
    ..No signs of recurrence have been seen since its excision. Accordingly, the tumor was diagnosed as a primary leiomyoma of the pancreas...
  26. ncbi Structural and functional analysis of the Xestia c-nigrum granulovirus matrix metalloproteinase
    R Ko
    Laboratory of Molecular Entomology and Baculovirology, RIKEN, Wako, Saitama, Japan
    J Virol 74:11240-6. 2000
    ..The enzymatic activity was inhibited by two metalloproteinase inhibitors, EDTA and 1,10-phenanthroline. These results suggest that the XcGV MMP-3 gene homolog encodes a functional metalloproteinase...
  27. ncbi CD30-positive diffuse large B-cell lymphoma with microvillous features: so-called microvillous lymphoma
    A Liu
    Central Institute for Electron Microscopic Researches, Nippon Medical School, Tokyo, Japan
    J Clin Pathol 62:840-4. 2009
    ..The results of a panel of three markers (CD10(-), Bcl-6(+) and MUM1(+)) suggested that the present case of CD30-positive MVLs has an activated non-germinal centre B-cell origin...
  28. ncbi Early effects of electrical stimulation on osteogenesis
    K Yonemori
    Department of Orthopaedic Surgery, Faculty of Medicine, Kagoshima University, Japan
    Bone 19:173-80. 1996
    ....
  29. ncbi Complete cure of malignant lymphoma of the stomach with a huge adrenal lesion achieved by preoperative chemotherapy and surgery: report of a case
    T Matsuda
    Department of Gastroenterology, Nippon Medical School Tama-Nagayama Hospital, Tama-shi, Tokyo, Japan
    Surg Today 31:62-7. 2001
    ..The postoperative course of this patient was uneventful. She is still alive without any sign of tumor recurrence 6 years after her operation, and is being followed up at the outpatient clinic...
  30. ncbi A case of solitary fibrous tumor of the meninges
    N Sanno
    Department of Neurosurgery, Tama Nagayama Hospital, Nippon Medical School, Tokyo, Japan
    Brain Tumor Pathol 18:43-7. 2001
    ..The tumor was diagnosed as SFT of the meninges. We report the clinical and histological features of this newly described tumor with a heterogeneous component...
  31. ncbi Polymorphism of the solute carrier family 12 (sodium/chloride transporters) member 3, SLC12A3, gene at exon 23 (+78G/A: Arg913Gln) is associated with elevation of urinary albumin excretion in Japanese patients with type 2 diabetes: a 10-year longitudinal
    K Nishiyama
    Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Diabetologia 48:1335-8. 2005
    ..The aim of this study was to confirm the effect of this polymorphism on the elevation of urinary albumin excretion in type 2 diabetic patients...
  32. ncbi The effect of cellular proliferative activity on recurrence and local tumour extent of localized giant cell tumour of tendon sheath
    Y Kitagawa
    Department of Orthopaedic Surgery, Pathology and Surgical Pathology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    J Hand Surg Br 29:604-7. 2004
    ..These results suggest that the proliferative activity of localized giant cell tumour of tendon sheath is not related to its high recurrence rate and local aggressiveness...
  33. ncbi Increase of CC chemokine receptor 4-positive cells in the peripheral CD4 cells in dogs with atopic dermatitis or experimentally sensitized to Japanese cedar pollen
    S Maeda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Clin Exp Allergy 34:1467-73. 2004
    ....
  34. ncbi Biomechanical analysis of buckling alignment of the cervical spine. Predictive value for subaxial subluxation after occipitocervical fusion
    S Matsunaga
    Department of Orthopaedic Surgery, Faculty of Medicine, Kagoshima University, Japan
    Spine (Phila Pa 1976) 22:765-71. 1997
    ..Preoperative values of buckling over 10 x 10(-4) constitute a risk factor for subaxial subluxation after occipitocervical fusion...
  35. ncbi Beijing family Mycobacterium tuberculosis isolated from throughout Japan: phylogeny and genetic features
    S Maeda
    The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo, Japan
    Int J Tuberc Lung Dis 14:1201-4. 2010
    ..JATA-VNTR might be useful for the phylogenetic classification in populations where ancient Beijing strains are frequently isolated...
  36. ncbi Expression pattern of the mitochondrial capsule selenoprotein mRNA in the mouse testis after puberty; in situ hybridization study
    S Y Nam
    Department of Veterinary Anatomy, Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan
    J Vet Med Sci 59:983-8. 1997
    ..These findings suggest that MCS gene transcription may be up-regulated after puberty in the mouse testis...
  37. ncbi Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene
    M Kai
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    FEMS Microbiol Lett 177:231-5. 1999
    ..This is the first paper which links the mutations in DHPS and sulfonamide resistance in M. leprae. This finding is medically and socially relevant, since leprosy is still a big problem in certain regions...
  38. ncbi Genomic sequence of a 320-kb segment of the Z chromosome of Bombyx mori containing a kettin ortholog
    Y Koike
    Department of Agricultural and Environmental Biology, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, 113 8657 Tokyo, Japan
    Mol Genet Genomics 269:137-49. 2003
    ..The implications of these findings for the evolution and function of the Z chromosome in Lepidoptera are discussed...
  39. ncbi Functional impact of human collagen alpha2(XI) gene polymorphism in pathogenesis of ossification of the posterior longitudinal ligament of the spine
    S Maeda
    Department of Orthopedic Surgery, Faculty of Medicine, Kagoshima University, Japan
    J Bone Miner Res 16:948-57. 2001
    ....
  40. ncbi Methylation of CpG loci in 5'-flanking region alters steady-state expression of adenomatous polyposis coli gene in colon cancer cell lines
    Y Sakamoto
    Second Department of Pathology, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    J Cell Biochem 80:415-23. 2001
    ....
  41. ncbi Identification of peptides containing T-cell epitopes of Japanese cedar (Cryptomeria japonica) pollen allergen (Cry j 1) in dogs
    K Masuda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyou-ku, 113-8657, Japan
    Vet Immunol Immunopathol 102:45-52. 2004
    ..The results in atopic dogs sensitive to CJ pollen antigen will also provide useful information on necessity to develop a tailor-made immunotherapy using reactive peptides in each dog...
  42. ncbi Molecular cloning of canine thymus and activation-regulated chemokine (TARC) gene and its expression in various tissues
    S Maeda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Vet Med Sci 63:1035-8. 2001
    ..TARC cDNA clone obtained in this study will be useful for further investigation on allergic diseases in dogs...
  43. ncbi Nitric oxide at a low concentration protects murine macrophage RAW264 cells against nitric oxide-induced death via cGMP signaling pathway
    Y Yoshioka
    Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573-0101, Japan
    Br J Pharmacol 139:28-34. 2003
    ..7. These results indicate that low-dose NO protects RAW264 cells from NO-induced apoptosis through cGMP production and activation of protein kinase G...
  44. ncbi Cloning and characterization of an inhibitor of apoptosis protein (IAP) from Bombyx mori
    Q Huang
    Department of Entomology, University of California, Davis 95616, USA
    Biochim Biophys Acta 1499:191-8. 2001
    ..These results suggest that suppression of apoptosis by lepidopteran IAPs in insect cells may involve inhibition of an upstream initiator caspase in the conserved mitochondria/cytochrome-c pathway for apoptosis...
  45. ncbi Secondary activation of c-abl may be related to translocation to the nucleolar organizer region in an in vitro cultured rat leukemia cell line (K3D)
    R Takahashi
    Proc Natl Acad Sci U S A 83:1079-83. 1986
    ..These results provide evidence of secondary c-onc activation during karyotypic evolution of cloned malignant cells...
  46. ncbi Cloning and sequence analysis of a cDNA encoding porcine mitochondrial aspartate aminotransferase precursor
    T Joh
    Proc Natl Acad Sci U S A 82:6065-9. 1985
    ..The sequence of this 29-amino acid mAspATase precursor segment was compared with the presequences of other mitochondrial enzymes...
  47. ncbi Variation in MT expression in early-stage depressed-type and polypoid-type colorectal tumours
    K Kuroda
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Disease, Kobe University Graduate School of Medicine, Kobe, Japan
    Eur J Cancer 38:1879-87. 2002
    ..Furthermore, MT-positive distribution may reflect genetic differences between the polypoid and depressed-type...
  48. ncbi Structural comparisons between mouse and human prealbumin
    S Wakasugi
    J Biochem 98:1707-14. 1985
    ..The cloned cDNA provided essential information for manipulating amyloidosis in mice...
  49. ncbi Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes
    A Kanazawa
    Laboratory for Diabetic Nephropathy, SNP Research Centre, Institute of Physical and Chemical Research, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, 230 0045, Japan
    Diabetologia 48:1315-22. 2005
    ..The present study aimed to examine the associations of single nucleotide polymorphisms (SNPs) in genes encoding members of the Krüppel-like-factor (KLF) family with type 2 diabetes in a large cohort of Japanese subjects...
  50. ncbi Gene expression profiling of exercise-induced cardiac hypertrophy in rats
    M Iemitsu
    Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Acta Physiol Scand 185:259-70. 2005
    ..g. GSK-3beta, Cain, and ET-1) and that other genes (e.g. BNP, ACE) may differentiate physiological from pathological LV hypertrophy...
  51. ncbi A novel transthyretin mutation associated with familial amyloidotic polyneuropathy
    T Murakami
    First Department of Internal Medicine, Kumamoto University Medical School, Japan
    Biochem Biophys Res Commun 182:520-6. 1992
    ..The mutation was confirmed using allele-specific olgonucleotide hybridization procedures. This most likely represents a de novo mutation since neither parent carries the mutant allele...
  52. ncbi Gastric cancer among peptic ulcer patients: retrospective, long-term follow-up
    M Ogura
    Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, 1 6 1 Marunouchi, Tokyo 100 0005, Japan
    Dig Liver Dis 38:811-4. 2006
    ..Patients with duodenal ulcer are not at high risk although Helicobacter pylori infection is no doubt associated with gastric cancer development. However, little is known about the risk after long-term follow-up...
  53. ncbi ELMO1 increases expression of extracellular matrix proteins and inhibits cell adhesion to ECMs
    A Shimazaki
    Laboratory for Diabetic Nephropathy, SNP Research Center, The Institute of Physical and Chemical Research, Yokohama, Kanagawa, Japan
    Kidney Int 70:1769-76. 2006
    ..These results suggest that the ELMO1 contributes to the development and progression of chronic glomerular injury through the dysregulation of ECM metabolism and the reduction in cell adhesive properties to ECMs...
  54. ncbi Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population
    T Hayashi
    Laboratory for Diabetic Nephropathy, SNP Research Centre, The Institute of Physical and Chemical Research, Yokohama, Kanagawa 230 0045, Japan
    Diabetologia 50:980-4. 2007
    ..To further investigate the involvement of TCF7L2 in conferring susceptibility to type 2 diabetes, we examined the association of TCF7L2 polymorphisms with type 2 diabetes in a Japanese population...
  55. ncbi Voluntary running exercise attenuates the progression of endothelial dysfunction and arterial calcification in ovariectomized rats
    J H Park
    Institute of Health and Sports Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Acta Physiol (Oxf) 193:47-55. 2008
    ..Exercise training improves arterial stiffness and calcification. However, the mechanism of exercise training-induced improvement of arterial stiffness and calcification remains unclear...
  56. ncbi Endoscopic surveillance for gastric remnant cancer after early cancer surgery
    O Hosokawa
    Department of Surgery, Fukui Prefectural Hospital, Fukui, Japan
    Endoscopy 34:469-73. 2002
    ....
  57. ncbi Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone
    V Episkopou
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032
    Proc Natl Acad Sci U S A 90:2375-9. 1993
    ..These observations demonstrate that the TTR protein maintains normal levels of these metabolites in the circulating plasma...
  58. ncbi The first stage of transforming growth factor beta1 activation is release of the large latent complex from the extracellular matrix of growth plate chondrocytes by matrix vesicle stromelysin-1 (MMP-3)
    S Maeda
    The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA
    Calcif Tissue Int 70:54-65. 2002
    ..Thus, the data suggest that release of the large latent TGF-bl complex from the matrix and activation of the latent growth factor are only two steps of what must be at least a three-step process...
  59. ncbi Homozygous serum amyloid P component-deficiency does not enhance regression of AA amyloid deposits
    I Usui
    First Department of Biochemistry, Yamanashi Medical University, Tamaho-cho, Yamanashi 409-3898, Japan
    Amyloid 8:101-4. 2001
    ....
  60. ncbi Analysis of amyloid deposition in a transgenic mouse model of homozygous familial amyloidotic polyneuropathy
    K Kohno
    Department of Biochemistry, Yamanashi Medical University, Yamanashi, Japan
    Am J Pathol 150:1497-508. 1997
    ..0-hMet 30. The T4-binding studies also demonstrated the presence of hybrid tetramers between mouse and human TTR subunits in the ttr+/+ transgenic mice expressing 6.0-hMet 30...
  61. ncbi Assessment of prognostic factors in follicular lymphoma patients
    E Kondo
    Department of Hematology and Chemotherapy, Aichi Cancer Center Hospital, Nagoya, Japan
    Int J Hematol 73:363-8. 2001
    ..9%, and 0.0%, respectively. The differences among these groups were significant at P < .01. The IPI for aggressive non-Hodgkin's lymphoma was found to be applicable to survival prediction for Japanese follicular lymphoma patients...
  62. ncbi Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma
    K Matsuo
    Division of Epidemiology and Prevention, the Department of Hematology and Chemotherapy, the Nagoya University Graduate School of Medicine, Japan
    Blood 97:3205-9. 2001
    ..Further studies to confirm the association and detailed biologic mechanisms are now required...
  63. ncbi Molecular cloning and analysis of the 5'-flanking region of the human bone morphogenetic protein-6 (BMP-6)
    H Tamada
    Second Department of Pathology, Kobe University School of Medicine, Japan
    Biochim Biophys Acta 1395:247-51. 1998
    ..Known steroid hormonal responsive elements, however, were not found. Although BMP-6 is classified as a member of the vgr-1 family, the structure of the promoter was similar to that of BMP-2 and 4...
  64. ncbi Suppression and acceleration of autoimmune diabetes by neutralization of endogenous interleukin-12 in NOD mice
    K Fujihira
    Department of Geriatric Medicine, Kobe University School of Medicine, Japan
    Diabetes 49:1998-2006. 2000
    ....
  65. ncbi Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene
    S Honda
    Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan
    Biochem Biophys Res Commun 252:445-9. 1998
    ..These results suggest an important participation of the aromatase gene in the reproductive behaviors...
  66. ncbi Disruption of aldose reductase gene (Akr1b1) causes defect in urinary concentrating ability and divalent cation homeostasis
    K Aida
    Third Department of Internal Medicine, Yamanashi Medical University, Tamaho, Yamanashi, 409 3898, Japan
    Biochem Biophys Res Commun 277:281-6. 2000
    ..We report here that the mice lacking AKR1B1 showed hypercalciuria, hypercalcemia, hypermagnesemia, and reduced ability to concentrate urine, suggesting a new physiological role of AKR1B1 in divalent cation homeostasis...
  67. ncbi Neuron-specific Cdk5 kinase is responsible for mitosis-independent phosphorylation of c-Src at Ser75 in human Y79 retinoblastoma cells
    G Kato
    Department of Biochemistry, Yamanashi Medical University, Nakakoma, Yamanashi, 409 3898, Japan
    J Biochem 126:957-61. 1999
    ....
  68. ncbi A new member of the GTPase superfamily that is upregulated in highly metastatic cells
    T Nakaji
    Second Department of Pathology, Kobe University Medical School, Japan
    Cancer Lett 147:139-47. 1999
    ..TIB929 was mapped on mouse chromosome 4D, syntenic to human chromosome 1p. The results suggested an involvement of TIB929 in malignant progression...
  69. ncbi Alternative splicing of the erythropoietin receptor gene correlates with erythroid differentiation in rat hematopoietic and leukemic cells
    M Fujita
    Second Department of Pathology, Kobe University School of Medicine, Kusunoki cho, Chuo Ku, Japan
    Cancer Lett 112:47-55. 1997
    ..Thus, expression of EpoR-S may play an important role in differentiation of rat erythroid cells...
  70. ncbi [A case of advanced gastric cancer with multiple liver metastases in an elderly patient that responded dramatically to UFT therapy]
    S Matsusaka
    Dept. of Surgery, Takarazuka City Hospital
    Gan To Kagaku Ryoho 28:995-7. 2001
    ..Resection of the primary lesion with a regimen of a small oral dose of UFT was remarkably effective in this elderly gastric cancer patient with complications from multiple hepatic metastases...
  71. ncbi Expression of parathyroid hormone-related protein (PTHrP) in parathyroid tissue under normal and pathological conditions
    R Kitazawa
    Department of Biomedical Informatics, Kobe University Graduate School of Medicine, Japan
    Histol Histopathol 17:179-84. 2002
    ..We speculate that PTHrP could act through the paracrine/autocrine mechanism to regulate proliferation and differentiation of normal and neoplastic parathyroid cells...
  72. ncbi A replacement vector used to introduce subtle mutations into mouse genes
    K Horie
    Department of Medical Genetics, Osaka University, Japan
    Gene 166:197-204. 1995
    ..In five independently isolated random integrants of the same vector DNA, the cassette of selection markers was excised efficiently by recombination within the duplication...
  73. ncbi Antisense-mediated reduction in thrombospondin-1 expression reduces cell motility in malignant glioma cells
    K Amagasaki
    Department of Neurosurgery, Yamanashi Medical University, Tamaho-machi, Yamanashi, Japan
    Int J Cancer 94:508-12. 2001
    ..These results suggest that TSP-1 secreted by malignant glioma cells is involved in the motility of glioma cells...
  74. ncbi Multidrug resistant Mycobacterium leprae from patients with leprosy
    S Maeda
    Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama-shi, Tokyo 189-0002, Japan
    Antimicrob Agents Chemother 45:3635-9. 2001
    ..Thirteen isolates (14.8%) showed representative mutations in more than two genes, suggesting the emergence of multidrug-resistant M. leprae...
  75. ncbi Endothelin-1 production is enhanced by rotenone, a mitochondrial complex I inhibitor, in cultured rat cardiomyocytes
    K I Yuhki
    Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Cardiovasc Pharmacol 38:850-8. 2001
    ....
  76. ncbi Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat
    M Iemitsu
    Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-0006, Japan
    Am J Physiol Regul Integr Comp Physiol 281:R2029-36. 2001
    ..We demonstrated for the first time that the manner of mRNA expression of various cardiovascular regulating factors in the heart differs between physiological and pathological cardiac hypertrophy...
  77. ncbi Quantitative analysis of chondroitin sulfate isomers in intervertebral disk chondrocyte culture using capillary electrophoresis
    S Maeda
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0126, USA
    J Vet Med Sci 63:1039-43. 2001
    ..Amounts of newly synthesized CS6 and CS4 in the intervertebral disk chondrocyte three-dimensional culture were quantified by this method after the proteoglycans were extracted by equilibrium density centrifugation...
  78. ncbi Dinucleotide repeat polymorphism of matrix metalloproteinase-9 gene is associated with diabetic nephropathy
    S Maeda
    Third Department of Medicine, Shiga University of Medical Science, Otsu, Japan
    Kidney Int 60:1428-34. 2001
    ....
  79. ncbi Molecular cloning and characterization of human bone morphogenic protein (BMP)-5 gene promoter
    M Sakaue
    Second Department of Pathology, Kobe University School of Medicine, Japan
    Biochem Biophys Res Commun 221:768-72. 1996
    ..5 kb promoter region contains two transcription start sites, a canonical TATA box (-17 approximately -12) and a number of consensus recognition sequences including GATA-1 (-582 approximately -576) and engrailed (-549 approximately -541)...
  80. ncbi Transient activation of c-Jun NH2-terminal kinase by growth factors influences survival but not apoptosis of human thyrocytes
    S S Shklyaev
    Department of Nature Medicine, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Japan
    Thyroid 11:629-36. 2001
    ..Our results suggest that JNK activation does not induce apoptosis but is associated with survival or transformation of human thyroid cells...
  81. ncbi Myocardial expression of endothelin-2 is altered reciprocally to that of endothelin-1 during ischemia of cardiomyocytes in vitro and during heart failure in vivo
    Y Kakinuma
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Life Sci 65:1671-83. 1999
    ....