Research Topics
| Shin KwakSummaryAffiliation: University of Tokyo Country: Japan Publications
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Detail Information
Publications
Glutamate receptors: RNA editing and death of motor neuronsYukio Kawahara
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Nature 427:801. 2004....
AMPA receptor-mediated neuronal death in sporadic ALSShin Kwak
Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo
Neuropathology 30:182-8. 2010..To this end, normalization of ADAR2 activity in motor neurons may become a therapeutic strategy for sporadic ALS...- Newly identified ADAR-mediated A-to-I editing positions as a tool for ALS researchShin Kwak
Department of Neurology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
RNA Biol 5:193-7. 2008..Therefore, the extent of CYFIP2 K/E site-editing may be an additional marker for ADAR2 activity in neuronal and other types of cells in vivo, as well as in vitro, and thus is considered to be a good tool for sporadic ALS research... - Deficient RNA editing of GluR2 and neuronal death in amyotropic lateral sclerosisShin Kwak
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655 Tokyo, Japan
J Mol Med (Berl) 83:110-20. 2005..The restoration of this enzyme activity in ALS motor neurons may open the novel strategy for specific ALS therapy... - Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2Takuto Hideyama
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, University of Tokyo, Bunkyo ku, Tokyo, Japan
J Neurosci 30:11917-25. 2010..2000). Thus, loss of ADAR2 activity causes AMPA receptor-mediated death of motor neurons... - Underediting of GluR2 mRNA, a neuronal death inducing molecular change in sporadic ALS, does not occur in motor neurons in ALS1 or SBMAYukio Kawahara
Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Neurosci Res 54:11-4. 2006..It seems likely that the death cascade is different among the dying motor neurons in sporadic ALS, familial ALS with mutant SOD1 and SBMA... - Slow and selective death of spinal motor neurons in vivo by intrathecal infusion of kainic acid: implications for AMPA receptor-mediated excitotoxicity in ALSHui Sun
Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
J Neurochem 98:782-91. 2006..e. calcium-permeable) AMPA receptors. This rat model may be useful in investigating ALS etiology... - Novel etiological and therapeutic strategies for neurodiseases: RNA editing enzyme abnormality in sporadic amyotrophic lateral sclerosisTakuto Hideyama
Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan
J Pharmacol Sci 113:9-13. 2010..Our review will include a discussion of new ADAR2 substrates that may be useful for research on sporadic ALS... - Human spinal motoneurons express low relative abundance of GluR2 mRNA: an implication for excitotoxicity in ALSYukio Kawahara
Department of Neurology, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo, Japan
J Neurochem 85:680-9. 2003..However, the low relative abundance of GluR2 might provide spinal motoneurons with conditions that are easily affected by changes of AMPA receptor properties including deficient GluR2 mRNA editing in ALS... - Low editing efficiency of GluR2 mRNA is associated with a low relative abundance of ADAR2 mRNA in white matter of normal human brainYukio Kawahara
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Eur J Neurosci 18:23-33. 2003..These results suggest that Q/R site of GluRs editing is regulated in a regional, and hence presumably cell-specific, manner and that the GluR2 Q/R site editing is critically regulated by ADAR2 in human brain... - Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neuronsTakuto Hideyama
CREST, Japan Science and Technology Agency, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Neurobiol Dis 45:1121-8. 2012..These results indicate that ADAR2 downregulation is a profound pathological change relevant to death of motor neurons in ALS... - Determination of editors at the novel A-to-I editing positionsYoshinori Nishimoto
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Neurosci Res 61:201-6. 2008..Because ADAR2 underactivity may be a causative molecular change of death of motor neurons in sporadic amyotrophic lateral sclerosis (ALS), this newly identified ADAR2-mediated editing position may become a useful tool for ALS research... - RNA editing of the Q/R site of GluA2 in different cultured cell lines that constitutively express different levels of RNA editing enzyme ADAR2Takenari Yamashita
Department of Neurology, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
Neurosci Res 73:42-8. 2012.... - [AMPA receptor-mediated neuronal death and amyotrophic lateral sclerosis]Takuto Hideyama
Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
No To Shinkei 57:585-98. 2005 - GluR4c, an alternative splicing isoform of GluR4, is abundantly expressed in the adult human brainYukio Kawahara
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 8655, Japan
Brain Res Mol Brain Res 127:150-5. 2004..The GluR4 subunit may play a pivotal role in regulating channel properties as well as trafficking of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors in the adult human brain... - Expression profile of AMPA receptor subunit mRNA in single adult rat brain and spinal cord neurons in situHui Sun
Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Neurosci Res 52:228-34. 2005..The unique AMPA receptor expression profile of motoneurons may render them selectively vulnerable to AMPA receptor-mediated excitotoxicity... - Novel splice variants of human ADAR2 mRNA: skipping of the exon encoding the dsRNA-binding domains, and multiple C-terminal splice sitesYukio Kawahara
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Gene 363:193-201. 2005..Among them, variants containing the long C-terminus are translated in human brains in situ, implying that alternative splicing in the 3' UTR of ADAR2 might regulate translational efficiency and mRNA stability in vivo... - Regulation of glutamate receptor RNA editing and ADAR mRNA expression in developing human normal and Down's syndrome brainsYukio Kawahara
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan
Brain Res Dev Brain Res 148:151-5. 2004..ADAR2 mRNA was not overexpressed in the brains of Down's syndrome subjects, nor was there any evidence of changes in the RNA editing efficiency of their GluRs... - The abnormal processing of TDP-43 is not an upstream event of reduced ADAR2 activity in ALS motor neuronsTakenari Yamashita
CREST, Japan Science and Technology Agency, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Neurosci Res 73:153-60. 2012..These results suggest that the abnormal processing of TDP-43 is not an upstream event of inefficient GluA2 Q/R site editing in the motor neurons of sporadic ALS patients... - Calcium-permeable AMPA channels in neurodegenerative disease and ischemiaShin Kwak
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655 Tokyo, Japan
Curr Opin Neurobiol 16:281-7. 2006..The targeting of these channels might provide efficacious new avenues in the therapy of certain neurological diseases... - Recent advances in the study of AMPA receptorsTakeshi Suzuki
Department of Pharmacology, Kyoritsu College of Pharmacy, Tokyo, Japan
Nihon Yakurigaku Zasshi 122:515-26. 2003..Glioblastoma cells also express Ca(2+)-permeable AMPA receptors, and their conversion to Ca(2+)-impermeable receptors inhibits cell locomotion and induces apoptosis... - A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathologyTakenari Yamashita
CREST, Japan Science and Technology Agency, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Nat Commun 3:1307. 2012.... - [Molecular link between inefficient GluA2 RNA editing and TDP-43 pathology in ALS motor neurons]Shin Kwak
Department of Neurology, The University of Tokyo, Tokyo, Japan
Brain Nerve 64:549-56. 2012.... - A positron emission tomography study on the role of nigral lesions in parkinsonism in patients with amyotrophic lateral sclerosisTakuto Hideyama
Department of Neurology, Graduate School of Medicine, and Department of Radiology, The University of Tokyo, Tokyo, Japan
Arch Neurol 63:1719-22. 2006..Patients with amyotrophic lateral sclerosis (ALS) sometimes exhibit parkinsonism, but the lesion responsible for parkinsonism has not been extensively studied... - Age at onset influences on wide-ranged clinical features of sporadic amyotrophic lateral sclerosisNaoki Atsuta
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
J Neurol Sci 276:163-9. 2009..To profile the detailed clinical features of sporadic amyotrophic lateral sclerosis (ALS) on large-scale samples in Japan... - Aceruloplasminemia in a Japanese woman with a novel mutation of CP gene: clinical presentations and analysis of genetic and molecular pathogenesisAyumi Hida
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
J Neurol Sci 298:136-9. 2010..Thus, our report on this novel mutant indicates the previously unreported importance of carboxy-terminus residues in the secretion pathway... - Excitotoxicity and ALS: what is unique about the AMPA receptors expressed on spinal motor neurons?Yukio Kawahara
The Wistar Institute, Philadelphia, PA 19104, USA
Amyotroph Lateral Scler Other Motor Neuron Disord 6:131-44. 2005..This review focuses on recent progress on the molecular dynamics of AMPA receptors and discusses the pathophysiology of selective motor neuron death mediated by AMPA receptors in individuals affected with sporadic ALS... - [ALS and excitatory amino acid]Hitoshi Aizawa
Division of Neurology, Department of Internal Medicine, Asahik awa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
Brain Nerve 59:1117-27. 2007.... - Quantitative evaluation of the pyramidal tract segmented by diffusion tensor tractography: feasibility study in patients with amyotrophic lateral sclerosisShigeki Aoki
Department of Radiology, University of Tokyo Hospital, Tokyo 113-8655, Japan
Radiat Med 23:195-9. 2005..561). CONCLUSION: DTT could segmentate certain white matter tracts and evaluate them quantitatively. It could depict the subtle changes between subtypes of ALS as well as the changes between the patients and volunteers...