T Kuwaki

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Endothelin and neural crest development
    H Kurihara
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Cell Mol Biol (Noisy-le-grand) 45:639-51. 1999
  2. ncbi request reprint Role of endothelin-1 in stress response in the central nervous system
    Y Kurihara
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Am J Physiol Regul Integr Comp Physiol 279:R515-21. 2000
  3. ncbi request reprint Modulatory effects of rat endothelin on central cardiovascular control in rats
    T Kuwaki
    Department of Physiology, Faculty of Medicine, University of Tokyo, Japan
    Jpn J Physiol 40:97-116. 1990
  4. ncbi request reprint Renal damage and salt-dependent hypertension in aged transgenic mice overexpressing endothelin-1
    T Shindo
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Mol Med (Berl) 80:105-16. 2002
  5. ncbi request reprint Gene expression of endothelin isoforms and receptors in endothelin-1 knockout mice
    K Maemura
    Third Department of Internal Medicine, University of Tokyo, Japan
    J Cardiovasc Pharmacol 26:S17-21. 1995
  6. ncbi request reprint Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1
    T Kuwaki
    Department of Physiology, Faculty of Medicine, University of Tokyo, Japan
    Am J Physiol 270:R1279-86. 1996
  7. ncbi request reprint Elevated sympathetic nervous activity in mice deficient in alphaCGRP
    Y Oh-hashi
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Circ Res 89:983-90. 2001
  8. ncbi request reprint Responses of blood pressure and catecholamine metabolism to high salt loading in endothelin-1 knockout mice
    H Morita
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Hypertens Res 22:11-6. 1999
  9. ncbi request reprint Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene
    T Shindo
    Department of Cardiovascular Medicine, University of Tokyo, and Institute for Adult Disease, Asahi Life Foundation, Tokyo, Japan
    Circulation 104:1964-71. 2001
  10. ncbi request reprint Modulatory effects of endothelin-1 on central cardiovascular control in rats
    T Kuwaki
    Department of Physiology, Faculty of Medicine, University of Tokyo, Japan
    Jpn J Physiol 40:827-41. 1990

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Endothelin and neural crest development
    H Kurihara
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Cell Mol Biol (Noisy-le-grand) 45:639-51. 1999
    ....
  2. ncbi request reprint Role of endothelin-1 in stress response in the central nervous system
    Y Kurihara
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Am J Physiol Regul Integr Comp Physiol 279:R515-21. 2000
    ..Our findings suggest that ET-1 modulates central coordination of stress responses in close association with catecholamine metabolism...
  3. ncbi request reprint Modulatory effects of rat endothelin on central cardiovascular control in rats
    T Kuwaki
    Department of Physiology, Faculty of Medicine, University of Tokyo, Japan
    Jpn J Physiol 40:97-116. 1990
    ....
  4. ncbi request reprint Renal damage and salt-dependent hypertension in aged transgenic mice overexpressing endothelin-1
    T Shindo
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Mol Med (Berl) 80:105-16. 2002
    ..It thus appears that mild, chronic overproduction of ET-1 does not primarily cause hypertension but triggers damaging changes in the kidney which lead to the susceptibility to salt-induced hypertension...
  5. ncbi request reprint Gene expression of endothelin isoforms and receptors in endothelin-1 knockout mice
    K Maemura
    Third Department of Internal Medicine, University of Tokyo, Japan
    J Cardiovasc Pharmacol 26:S17-21. 1995
    ..Neither compensation by redundant expression of other ET isoforms nor upregulation of ET receptors could explain the elevated blood pressure in Edn1+/- heterozygous mice...
  6. ncbi request reprint Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1
    T Kuwaki
    Department of Physiology, Faculty of Medicine, University of Tokyo, Japan
    Am J Physiol 270:R1279-86. 1996
    ..Our results demonstrate that ventilatory responses to hypoxia and hypercapnia are impaired in ET-1-deficient mice and suggest that endogenous ET-1 participates in the physiological control of ventilation...
  7. ncbi request reprint Elevated sympathetic nervous activity in mice deficient in alphaCGRP
    Y Oh-hashi
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Circ Res 89:983-90. 2001
    ..These findings suggest that alphaCGRP contributes to the regulation of cardiovascular function through inhibitory modulation of sympathetic nervous activity...
  8. ncbi request reprint Responses of blood pressure and catecholamine metabolism to high salt loading in endothelin-1 knockout mice
    H Morita
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Hypertens Res 22:11-6. 1999
    ..We conclude that physiological changes in ET-1 production do not affect the responses of blood pressure and catecholamine metabolism to salt loading, although the renal ET-1 content is decreased by salt loading...
  9. ncbi request reprint Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene
    T Shindo
    Department of Cardiovascular Medicine, University of Tokyo, and Institute for Adult Disease, Asahi Life Foundation, Tokyo, Japan
    Circulation 104:1964-71. 2001
    ..Levels of AM are markedly increased in the fetoplacental circulation during pregnancy, although its function there remains unknown. To clarify the physiological functions of AM, we chose a gene-targeting strategy in mice...
  10. ncbi request reprint Modulatory effects of endothelin-1 on central cardiovascular control in rats
    T Kuwaki
    Department of Physiology, Faculty of Medicine, University of Tokyo, Japan
    Jpn J Physiol 40:827-41. 1990
    ..We conclude that intracisternally administered ET-1 modulates tonic and reflex control of AP and sympathetic vasomotor activity and that the VSM appears to be involved critically in this modulation...
  11. ncbi request reprint Physiological role of brain endothelin in the central autonomic control: from neuron to knockout mouse
    T Kuwaki
    Department of Physiology, Faculty of Medicine, University of Tokyo, Japan
    Prog Neurobiol 51:545-79. 1997
    ..Definitive evidence is expected from thorough analyses of knockout mice by applying conventional experimental methods...
  12. ncbi request reprint Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1
    Y Kurihara
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Nature 368:703-10. 1994
    ..These results suggest that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis...
  13. ncbi request reprint Homocysteine as a risk factor for restenosis after coronary angioplasty
    H Morita
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Thromb Haemost 84:27-31. 2000
    ..These results suggest that plasma homocysteine is a potential risk factor of restenosis after PTCA, and therapeutic strategy targeted against hyperhomocysteinemia may be beneficial for preventing restenosis...
  14. ncbi request reprint Postnatal development of blood pressure and baroreflex in mice
    T Ishii
    Department of Autonomic Physiology, Graduate School of Medicine, Chiba University, Japan
    Auton Neurosci 94:34-41. 2001
    ..We conclude that pulsatile blood pressure can be accurately measured by the servo null method even in the newborn mice and that baroreflex heart rate control mature at around 2 weeks after birth in the mice...
  15. pmc Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1
    H Abe
    Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 101:1784-8. 1998
    ..Thus, insulin resistance plays an important role in the clustering of coronary risk factors which may accelerate the progression of atherosclerosis in subjects with insulin resistance...
  16. ncbi request reprint Identification of Ki23819, a highly potent inhibitor of kinase activity of mutant FLT3 receptor tyrosine kinase
    Y Komeno
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Leukemia 19:930-5. 2005
    ..FLT3-ITD-dependent activation of the downstream signaling proteins ERK and STAT5 was also inhibited within similar concentration ranges. Thus, Ki23819 is a potent in vitro inhibitor of FLT3...
  17. ncbi request reprint Increased sensitivity to acute and persistent pain in neuron-specific endothelin-1 knockout mice
    F Hasue
    Department of Autonomic Physiology, 1 8 1, Nohana, Chuo Ku, Chiba shi, Chiba 260 8670, Japan
    Neuroscience 130:349-58. 2005
    ..The results of the present study suggest that neuronal ET-1 is involved in endogenous pain inhibitory control likely via pathways through the hypothalamus...
  18. ncbi request reprint Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice
    D E Clouthier
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Development 125:813-24. 1998
    ..These observations define a novel genetic pathway for inductive communication between cephalic neural crest cells and their environmental counterparts...
  19. ncbi request reprint Normal ventilation and ventilatory responses to chemical stimuli in juvenile mutant mice deficient in endothelin-3
    A Nakamura
    Department of Physiology, School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba City, 260 8670, Chiba, Japan
    Respir Physiol 124:1-9. 2001
    ..Our results indicate that ET-3 can not be considered as a common pathogenic mechanism for CCHS and HSCR at least in mice...
  20. ncbi request reprint Endothelin in the central control of cardiovascular and respiratory functions
    T Kuwaki
    Department of Physiology, School of Medicine, Chiba University, Japan
    Clin Exp Pharmacol Physiol 26:989-94. 1999
    ..6. We conclude that endogenous ET-1 plays an important role in the central neural control of circulation and respiration and that ETA receptors mediate this mechanism...
  21. ncbi request reprint Renal sympathetic nerve activity in mice: comparison between mice and rats and between normal and endothelin-1 deficient mice
    G Y Ling
    Department of Physiology, School of Medicine, Chiba University, Chiba 260 8670, Japan
    Brain Res 808:238-49. 1998
    ..Baroreceptor resetting and normally preserved hypoxia-induced chemoreflex may explain a part of the elevation of AP in ET-1 deficient mice...
  22. ncbi request reprint Elevation of blood pressure by genetic and pharmacological disruption of the ETB receptor in mice
    T Ohuchi
    Department of Physiology, Faculty of Medicine, The University of Tokyo, Tokyo 113, Japan
    Am J Physiol 276:R1071-7. 1999
    ....
  23. ncbi request reprint Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life
    T Suga
    Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan
    Am J Respir Cell Mol Biol 22:26-33. 2000
    ..The klotho mutant mouse is a useful laboratory animal model for examining the relationship between aging and pulmonary emphysema...