Toshihiko Kubota

Summary

Affiliation: University of Fukui
Country: Japan

Publications

  1. ncbi Successful removal after radiotherapy and vascular embolization in a huge tentorial epithelioid hemangioendothelioma: a case report
    Toshihiko Kubota
    Department of Neurosurgery, Faculty of Medical Sciences, Fukui University, Matsuoka, Fukui, Japan
    J Neurooncol 68:177-83. 2004
  2. ncbi Astroblastoma: immunohistochemical and ultrastructural study of distinctive epithelial and probable tanycytic differentiation
    Toshihiko Kubota
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Matsuoka cho, Yoshida gun, Fukui, Japan
    Neuropathology 26:72-81. 2006
  3. ncbi Fine structural study of a cerebral tumor characterized by a honeycomb appearance after a 20-year post-mortem interval
    Toshihiko Kubota
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Neuropathology 26:158-60. 2006
  4. doi Expression of vascular endothelial growth factor-A and mRNA stability factor HuR in human astrocytic tumors
    Kazunori Ido
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Yoshida gun, Fukui, Japan
    Neuropathology 28:604-11. 2008
  5. doi Clinicopathological features in the recurrence of oligodendroglioma and diffuse astrocytoma
    Hiroaki Takeuchi
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan
    Brain Tumor Pathol 29:140-7. 2012
  6. doi Melanocytoma in the orbital apex
    Kazufumi Sato
    Division of Neurosurgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, 23 Shimoaizuki, Matsuoka, Eiheiji cho, Yoshida gun, 910 1193, Fukui, Japan
    J Neurooncol 92:107-10. 2009
  7. doi Proliferation of vascular smooth muscle cells in glioblastoma multiforme
    Hiroaki Takeuchi
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Japan
    J Neurosurg 113:218-24. 2010
  8. doi Nestin expression in astrocytic tumors delineates tumor infiltration
    Ryuhei Kitai
    Department of Neurosurgery, Faculty of Medical Sciences, Fukui University, Matsuoka, Yoshida gun, Fukui 910 1193, Japan
    Brain Tumor Pathol 27:17-21. 2010
  9. doi Glioblastoma with oligodendroglial components: glioblastoma or anaplastic oligodendroglial tumors
    Hiroaki Takeuchi
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan
    Brain Tumor Pathol 29:154-9. 2012
  10. doi Expression of vascular endothelial growth factor-A and mRNA stability factor HuR in human meningiomas
    Takahiro Sakuma
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Yoshida gun, Fukui 910 1193, Japan
    J Neurooncol 88:143-55. 2008

Collaborators

Detail Information

Publications46

  1. ncbi Successful removal after radiotherapy and vascular embolization in a huge tentorial epithelioid hemangioendothelioma: a case report
    Toshihiko Kubota
    Department of Neurosurgery, Faculty of Medical Sciences, Fukui University, Matsuoka, Fukui, Japan
    J Neurooncol 68:177-83. 2004
    ..The patient is free from the tumor 9 years after the second operation. Thus, E-HE is a highly vascular-rich tumor to excise, and we stress need for preoperative embolization and/or irradiation to remove huge tumor completely...
  2. ncbi Astroblastoma: immunohistochemical and ultrastructural study of distinctive epithelial and probable tanycytic differentiation
    Toshihiko Kubota
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Matsuoka cho, Yoshida gun, Fukui, Japan
    Neuropathology 26:72-81. 2006
    ..Numerous microvilli protruded and basal lamina abutted on the tumor cell surface. We report these unique histological features, and stress that astroblastoma should be categorized as a specific type of neuroepithelial tumor...
  3. ncbi Fine structural study of a cerebral tumor characterized by a honeycomb appearance after a 20-year post-mortem interval
    Toshihiko Kubota
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Neuropathology 26:158-60. 2006
  4. doi Expression of vascular endothelial growth factor-A and mRNA stability factor HuR in human astrocytic tumors
    Kazunori Ido
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Yoshida gun, Fukui, Japan
    Neuropathology 28:604-11. 2008
    ..These findings suggest that the expression of VEGF-A and cytoplasmic translocation of HuR relates to the histological grade, and that HuR is involved in the upregulation of VEGF-A expression, in human astrocytic tumors...
  5. doi Clinicopathological features in the recurrence of oligodendroglioma and diffuse astrocytoma
    Hiroaki Takeuchi
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan
    Brain Tumor Pathol 29:140-7. 2012
    ..Our study suggested that the extent of GT and necrosis in recurrent OG was less than that in recurrent DA, and transformation to glioblastoma from oligodendroglial tumor was exceptional...
  6. doi Melanocytoma in the orbital apex
    Kazufumi Sato
    Division of Neurosurgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, 23 Shimoaizuki, Matsuoka, Eiheiji cho, Yoshida gun, 910 1193, Fukui, Japan
    J Neurooncol 92:107-10. 2009
    ..To our knowledge, this is the second published case of intraorbital melanocytoma initially confined to the orbital apex. Melanocytoma should be included in the differential diagnosis of intraorbital tumors in such a location...
  7. doi Proliferation of vascular smooth muscle cells in glioblastoma multiforme
    Hiroaki Takeuchi
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Japan
    J Neurosurg 113:218-24. 2010
    ....
  8. doi Nestin expression in astrocytic tumors delineates tumor infiltration
    Ryuhei Kitai
    Department of Neurosurgery, Faculty of Medical Sciences, Fukui University, Matsuoka, Yoshida gun, Fukui 910 1193, Japan
    Brain Tumor Pathol 27:17-21. 2010
    ..Overlaid images showed that nestin immunostaining delineated tumor invasion into adjacent gray and white matter. Nestin is a useful marker for examining the infiltration of malignant cells into surrounding tissue...
  9. doi Glioblastoma with oligodendroglial components: glioblastoma or anaplastic oligodendroglial tumors
    Hiroaki Takeuchi
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan
    Brain Tumor Pathol 29:154-9. 2012
    ..Therefore, we should not readily use the term glioblastoma with OG components. PNET-like components, which are considered rare in malignant gliomas, may be frequently identified in glioblastomas...
  10. doi Expression of vascular endothelial growth factor-A and mRNA stability factor HuR in human meningiomas
    Takahiro Sakuma
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Yoshida gun, Fukui 910 1193, Japan
    J Neurooncol 88:143-55. 2008
    ..These findings suggest that the expression of VEGF-A relates to the development of PTBE with meningiomas and the histological grade, and that HuR is involved in the upregulation of VEGF-A expression in human meningiomas...
  11. doi Prognostic significance of the immunohistochemical expression of O6-methylguanine-DNA methyltransferase, P-glycoprotein, and multidrug resistance protein-1 in glioblastomas
    Takao Nakagawa
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Yoshida gun, Fukui, Japan
    Neuropathology 29:379-88. 2009
    ....
  12. ncbi Cell-specific but p53-independent regulation of vascular endothelial growth factor expression by interferons in human glioblastoma cells
    Yongxue Yao
    Department of Neurosurgery, University of Fukui, Matsuoka, Fukui, 910 1193, Japan
    J Neurooncol 76:219-25. 2006
    ..These findings suggest that VEGF might be an indirect target gene of IFNs, and might provide insights into therapeutic applications of IFNs against angiogenesis-dependent tumors...
  13. ncbi Gene expression profiles of 1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU)-resistant C6 rat glioma cells
    Takao Nakagawa
    Faculty of Medical Sciences, Department of Neurosurgery, Univeristy of Fukui, 23 3 Shimoaizuki, Yoshida gun, 910 1193 Fukui, Japan
    J Neurooncol 79:271-9. 2006
    ..These findings may represent an undifferentiated state of ACNU-resistant glioma cells and a more aggressive phenotype in recurrent tumors following chemotherapy...
  14. doi Chromosome 1p and 19q deletions in malignant glioneuronal tumors with oligodendroglioma-like component
    Hiroaki Takeuchi
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, 23 3 Matsuoka Shimoaizuki, Eiheiji, Fukui, 910 1193, Japan
    J Neurooncol 91:33-8. 2009
    ..It is inappropriate to make a diagnosis of oligodendroglioma based only on morphological resemblance to oligodendroglia...
  15. ncbi The combined effects of multiple chemotherapeutic agents for malignant glioma cells
    Takao Nakagawa
    Department of Neurosurgery, University of Fukui, Matsuoka Shimoaizuki 23, Eiheiji cho, Yoshida gun, Fukui, 910 1193, Japan
    J Neurooncol 84:31-7. 2007
    ..This preclinical screening using median-effect analysis supports the design of clinical trials by indicating more effective combinations of antineoplastic agents for malignant gliomas...
  16. ncbi Epstein-Barr virus-associated primary central nervous system lymphoma in the Japanese population
    Ryuhei Kitai
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Fukui
    Neurol Med Chir (Tokyo) 50:114-8. 2010
    ..Infrequent association suggests a different pathogenetic mechanism in the evolution of these tumors. Geographical differences in the incidence of EBV-associated primary CNS lymphoma may reflect epidemiological factors...
  17. pmc Coincident choroid plexus carcinoma and adrenocortical tumor in an infant
    Kazuhiko Yoshida
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, 23 3, Shimoaizuki, Eiheiji cho, Fukui, 910 1193, Japan
    Brain Tumor Pathol 30:104-8. 2013
    ..The adrenocortical tumor was found with the manifestation of precocious puberty. TP53 gene mutation (exons 4-10) was not detected in either specimen. The patient had leptomeningeal dissemination and died 26 months later...
  18. ncbi Atlas hypoplasia associated with non-traumatic retro-odontoid mass
    Kazufumi Sato
    Division of Neurosurgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, Japan
    Neurol Med Chir (Tokyo) 46:202-5. 2006
    ..No histological confirmation of the retro-odontoid mass was obtained. Clinical manifestations improved after posterior decompression. Decompressive laminectomy of the atlas with or without fusion can achieve a good outcome in such cases...
  19. ncbi Cervical extradural meningioma with rapidly progressive myelopathy
    Hiroaki Takeuchi
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, 23 3 Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    J Clin Neurosci 13:397-400. 2006
    ..At surgery, the tumour was entirely extradural. Histological examination revealed a meningioma. The patient recovered without neurological deficit with no recurrence 3 years after surgery...
  20. ncbi Mitotic activity of multinucleated giant cells with glial fibrillary acidic protein immunoreactivity in glioblastomas: an immunohistochemical double labeling study
    Hiroaki Takeuchi
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, 23 3 Shimoaizuki, 910 1193, Matsuoka, Fukui, Japan
    J Neurooncol 78:15-8. 2006
    ..MNGCs identified in glioblastomas may develop via not only the proliferation of abnormal nuclei in a single tumor cell but also other processes...
  21. ncbi CD98 immunoreactivity in multinucleated giant cells of glioblastomas: an immunohistochemical double labeling study
    Hiroaki Takeuchi
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Neuropathology 28:127-31. 2008
    ..8 +/- 2.7%) was significantly lower than that of CD98- MNGCs (91.1 +/- 24.6%) (P < 0001). These results suggest that multinucleated giant cell formation may be developed by fusion among CD98- producing cells in glioblastomas...
  22. ncbi [Hypoxic ischemic encephalopathy with atypical findings on CT and MR imaging: two case reports]
    Hidetaka Arishima
    Department of Neurosurgery, University of Fukui, 23 3 Matsuokashimoaizuki, Eiheiji cho, Yoshida gun, Fukui 910 1193, Japan
    Brain Nerve 61:874-9. 2009
    ....
  23. doi Pathology of intracranial germ cell tumors
    Kazufumi Sato
    Division of Neurosurgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, Fukui, Japan
    Prog Neurol Surg 23:59-75. 2009
    ..Recently, p14 and c-kit gene alterations have been reported, particularly in some intracranial germinomas; however, their importance remains unclear...
  24. ncbi Prognostic significance of microvessel density determined by an anti-CD105/endoglin monoclonal antibody in astrocytic tumors: comparison with an anti-CD31 monoclonal antibody
    Yongxue Yao
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Neuropathology 25:201-6. 2005
    ..These findings suggest that anti-CD105 mAb may be a better marker than anti-CD31 mAb in evaluation of angiogenesis and prediction of prognosis in astrocytic tumors...
  25. doi A report of supratentorial leptomeningeal hemangioblastoma and a literature review
    Hiroaki Takeuchi
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan
    Neuropathology 28:98-102. 2008
    ..Immunohistochemistry for epithelial membrane antigen (EMA) and S100 may be helpful to make differential diagnosis. Electron microscopic investigation is essential to differentiate between meningiomas and other leptomeningeal tumors...
  26. ncbi Angiogenesis in primary central nervous system lymphoma (PCNSL)
    Hiroaki Takeuchi
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, 23 3 Matsuoka Shimoaizuki, Eiheiji, Fukui 910 1193, Japan
    J Neurooncol 84:141-5. 2007
    ..Angiogenesis is associated with VEGF expression and an absent BBB in the vessels of PCNSL. The BBB may be preserved in lesions with lymphoma cell infiltration, especially in VEGF- PCNSL. VEGF may have a prognostic effect in PCNSL...
  27. ncbi Neuronal loss and expression of neurotrophic factors in a model of rat chronic compressive spinal cord injury
    Kazuma Kasahara
    Department of Neurosurgery, University of Fukui, Fukui, Japan
    Spine (Phila Pa 1976) 31:2059-66. 2006
    ..An experimental animal study about neuronal loss and the expression of neurotrophic factors in the chronic compressive spinal cords...
  28. ncbi Primary central nervous system lymphoma secretes monocyte chemoattractant protein 1
    Ryuhei Kitai
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, 23 Shimoaizuki, Eiheiji, Yoshida, Fukui 910 1193, Japan
    Med Mol Morphol 40:18-22. 2007
    ..Confocal laser microscope revealed MCP-1 signals were present in the cells with CD20, a B-cell marker. We concluded that lymphoma cells produced MCP-1, which is an additional cytokine involved in the pathogenesis of PCNSL...
  29. ncbi Thymic mucosa-associated lymphoid tissue lymphoma associated with bilateral orbital pseudotumor
    Ryuhei Kitai
    Department of Neurosurgery, Faculties of Medical Sciences, Fukui University, Yoshida gun, Fukui, Japan
    Gen Thorac Cardiovasc Surg 57:566-9. 2009
    ..Eleven years later, a mediastinal tumor was incidentally discovered. A thymectomy was performed, and histological examination revealed that the mass was a MALT lymphoma. There was no recurrence with no further treatment...
  30. ncbi Immunohistochemical and ultrastructural study of chordoid glioma of the third ventricle: its tanycytic differentiation
    Kazufumi Sato
    Department of Neurosurgery, Fukui Medical University, 23 Shimoaizuki, Yoshida gun, Matsuoka cho, 910 1193 Fukui, Japan
    Acta Neuropathol 106:176-80. 2003
    ..This region includes the lamina terminalis, infundibular recess and median eminence, which corresponds to a tanycyte-rich area. These findings suggest a tanycytic origin of chordoid glioma...
  31. ncbi Malignant transformation of supratentorial clear cell ependymoma
    Masanori Kurimoto
    Department of Neurosurgery, University of Toyama, 2630 Sugitani, Toyama, Japan
    Neuropathology 29:299-302. 2009
    ..The autopsy specimens resembled a feature of glioblastoma but the tumor was sharply demarcated from the surrounding parenchyma...
  32. ncbi Radiological findings for arterial dissection of the anterior cerebral artery
    Toshiaki Kodera
    Department of Neurosurgery, Fukui General Hospital, Fukui 910 8561, Japan
    J Clin Neurosci 14:77-80. 2007
    ..We presume that the results were based on the velocity of the blood flow in the pseudolumen of the dissected artery, and we believe that CT angiography is a useful and less invasive diagnostic tool for intracranial arterial dissection...
  33. ncbi Acquisition of resistance to antitumor alkylating agent ACNU: a possible target of positron emission tomography monitoring
    Hideya Kawai
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Japan
    Nucl Med Biol 33:29-35. 2006
    ..Though difficult to be directly translated into clinical situation, the present study will provide a base to develop an appropriate protocol to assess tumor response to treatment by PET and to design effective treatment plans...
  34. ncbi Clinical implication and prognosis of normal baseline cerebral blood flow with impaired vascular reserve in patients with major cerebral artery occlusive disease
    Makoto Isozaki
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, 23 3 Matsuoka Shimoaizuki, Eiheiji cho, Fukui, 910 1193, Japan
    Ann Nucl Med 24:371-7. 2010
    ....
  35. ncbi Ultrastructure of capillary endothelium in pilocytic astrocytomas
    Hiroaki Takeuchi
    Department of Neurosurgery, Obama Community Hospital, Obama, Fukui 917 8567, Japan
    Brain Tumor Pathol 21:23-6. 2004
    ..Fenestration of the vessels and vascular abnormalities with degeneration are suggested to develop both contrast enhancement on neuroimaging and cystic formation in pilocytic astrocytomas...
  36. ncbi Glioma cells under hypoxic conditions block the brain microvascular endothelial cell death induced by serum starvation
    Yoshifumi Ueda
    Department of Neurosurgery, University of Fukui, Fukui, Japan
    J Neurochem 95:99-110. 2005
    ..These pathways may be one of the mechanisms by which angiogenesis is maintained in glioma tissues...
  37. ncbi Clival chordoma manifesting as nasal bleeding. A case report
    Ryuhei Kitai
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, 23 Shimoaizuki Matsuoka, Fukui, 9111193, Japan
    Neuroradiology 47:368-71. 2005
    ..This case demonstrates the importance of an exact differential diagnostic evaluation, including chordoma, by use of modern imaging techniques for nasal bleeding...
  38. ncbi Spinal tanycytic ependymoma with hematomyelia--case report--
    Kazufumi Sato
    Division of Neurosurgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui
    Neurol Med Chir (Tokyo) 45:168-71. 2005
    ..The soft gelatinous tumor was subtotally resected and the adjacent chronic liquid hematoma was aspirated. The immunohistochemical and ultrastructural findings indicated a diagnosis of tanycytic ependymoma...
  39. ncbi Meningeal plasma cell granuloma with relapsing polychondritis. Case report
    Kazufumi Sato
    Division of Neurosurgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Sciences, University of Fukui, Japan
    J Neurosurg 104:143-6. 2006
    ..In this case, the exact diagnosis of RP was made based on symptoms of respiratory tract chondritis, which was successfully treated by the placement of tracheobronchial stents...
  40. ncbi Epithelial differentiation and proliferative potential in spinal ependymomas
    Hiroaki Takeuchi
    Department of Neurosurgery, Fukui Medical University, Yoshida gun, Japan
    J Neurooncol 58:13-9. 2002
    ..Regional differences in ependymomas may influence not only clinical features but also histo-pathological characteristics...
  41. ncbi [A case of bacterial aneurysm complicated by severe infectious endocarditis]
    Hidetaka I Arishima
    Department of Neurosurgery, University of Fukui, 23 3 Matsuokashimoaizuki, Eiheiji cho, Yoshida gun, Fukui 910 1193, Japan
    No Shinkei Geka 37:803-9. 2009
    ....
  42. ncbi [Angiographic features of anoxic encephalopathy in the acute phase: a case report]
    Hidetaka Arishima
    Department of Neurosurgery, Harue Hospital, Japan
    No To Shinkei 55:977-82. 2003
    ..We found remarkable delays in cerebral circulation time in the acute phase of anoxic encephalopathy, which was considered to be caused by cytotoxic edema from severe hypoxia or ischemia...
  43. doi Pathology of pineal parenchymal tumors
    Kazufumi Sato
    Division of Neurosurgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, Fukui, Japan
    Prog Neurol Surg 23:12-25. 2009
    ..However, specific gene abnormalities involved in the tumorigenesis of PPTs have not been identified...
  44. ncbi Immunohistochemical and ultrastructural study of gap junction proteins connexin26 and 43 in human arachnoid villi and meningeal tumors
    Hidetaka Arishima
    Department of Neurosurgery, Fukui Medical University, Fukui, Japan
    J Neuropathol Exp Neurol 61:1048-55. 2002
    ..We proposed that Cx expression is one of the useful markers for the differentiation of meningioma and hemangiopericytoma...
  45. ncbi Evaluation of prognostic factors and clinical outcome in elderly patients in whom expansive laminoplasty is performed for cervical myelopathy due to multisegmental spondylotic canal stenosis. A retrospective comparison with younger patients
    Yuji Handa
    Department of Neurosurgery, Fukui Medical University, Japan
    J Neurosurg 96:173-9. 2002
    ....
  46. ncbi Interferons upregulate thymidine phosphorylase expression via JAK-STAT-dependent transcriptional activation and mRNA stabilization in human glioblastoma cells
    Yongxue Yao
    Department of Neurosurgery Department of Microbiology and Immunology, Indiana University School of Medicine and Walther Oncology Center, Indianapolis, IN 46202, USA
    J Neurooncol 72:217-23. 2005
    ..Combined treatment with IFN and 5-fluorouracil may be a useful therapeutic strategy for malignant gliomas...