Koji Kono

Summary

Affiliation: University of Yamanashi
Country: Japan

Publications

  1. ncbi request reprint Trypsin activity and bile acid concentrations in the esophagus after distal gastrectomy
    Koji Kono
    First Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Tamaho, Yamanashi, 409 3898, Japan
    Dig Dis Sci 51:1159-64. 2006
  2. ncbi request reprint Trastuzumab (Herceptin) enhances class I-restricted antigen presentation recognized by HER-2/neu-specific T cytotoxic lymphocytes
    Koji Kono
    First Department of Surgery, and Department of Neurosurgery, University of Yamanashi, Yamanashi, Japan
    Clin Cancer Res 10:2538-44. 2004
  3. doi request reprint Vaccination with multiple peptides derived from novel cancer-testis antigens can induce specific T-cell responses and clinical responses in advanced esophageal cancer
    Koji Kono
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    Cancer Sci 100:1502-9. 2009
  4. doi request reprint Protein-bound polysaccharide K partially prevents apoptosis of circulating T cells induced by anti-cancer drug S-1 in patients with gastric cancer
    Koji Kono
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    Oncology 74:143-9. 2008
  5. ncbi request reprint Oral trypsin inhibitor can improve reflux esophagitis after distal gastrectomy concomitant with decreased trypsin activity
    Koji Kono
    First Department of Surgery, University of Yamanashi, 1110 Tamaho, Yamanashi 409 3898, Japan
    Am J Surg 190:412-7. 2005
  6. ncbi request reprint CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers
    Koji Kono
    First Department of Surgery, University of Yamanashi, 1110 Shimokato, Tamaho, 409 3898 Yamanashi, Japan
    Cancer Immunol Immunother 55:1064-71. 2006
  7. ncbi request reprint Transient bloodletting of the short gastric vein in the reconstructed gastric tube improves gastric microcirculation during esophagectomy
    Koji Kono
    Department of Surgery, University of Yamanashi, 1110 Shimokato, 409 3898, Yamanashi, Japan
    World J Surg 31:780-4; discussion 785-6. 2007
  8. ncbi request reprint Evaluation of VEGF and VEGF-C expression in gastric cancer cells producing alpha-fetoprotein
    Shigeo Kamei
    First Department of Surgery, Yamanashi Medical University, 1110 Tamaho, Yamanashi 409 3898, Japan
    J Gastroenterol 38:540-7. 2003
  9. ncbi request reprint Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma
    Yoshihiko Kawaguchi
    First Department of Surgery, University of Yamanashi, Yamanashi 409 3898, Japan
    Int J Cancer 120:781-7. 2007
  10. ncbi request reprint Distribution of CD4+CD25high regulatory T-cells in tumor-draining lymph nodes in patients with gastric cancer
    Hiromichi Kawaida
    First Department of Surgery, University of Yamanashi, 1110 Shimokato, Tamaho, Yamanashi 409 3898, Japan
    J Surg Res 124:151-7. 2005

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Trypsin activity and bile acid concentrations in the esophagus after distal gastrectomy
    Koji Kono
    First Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Tamaho, Yamanashi, 409 3898, Japan
    Dig Dis Sci 51:1159-64. 2006
    ....
  2. ncbi request reprint Trastuzumab (Herceptin) enhances class I-restricted antigen presentation recognized by HER-2/neu-specific T cytotoxic lymphocytes
    Koji Kono
    First Department of Surgery, and Department of Neurosurgery, University of Yamanashi, Yamanashi, Japan
    Clin Cancer Res 10:2538-44. 2004
    ..One of the actions of Herceptin includes the internalization and degradation of HER-2, which might increase the amount of HER-2-derived peptides available for loading to MHC class I...
  3. doi request reprint Vaccination with multiple peptides derived from novel cancer-testis antigens can induce specific T-cell responses and clinical responses in advanced esophageal cancer
    Koji Kono
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    Cancer Sci 100:1502-9. 2009
    ..5 months. The cancer vaccine therapy using these three peptides demonstrated satisfactory safety and good immunogenicity as well as promising disease control rate, and therefore warrants further clinical studies...
  4. doi request reprint Protein-bound polysaccharide K partially prevents apoptosis of circulating T cells induced by anti-cancer drug S-1 in patients with gastric cancer
    Koji Kono
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    Oncology 74:143-9. 2008
    ....
  5. ncbi request reprint Oral trypsin inhibitor can improve reflux esophagitis after distal gastrectomy concomitant with decreased trypsin activity
    Koji Kono
    First Department of Surgery, University of Yamanashi, 1110 Tamaho, Yamanashi 409 3898, Japan
    Am J Surg 190:412-7. 2005
    ..We investigated the clinical usefulness and antitrypsin activity after treatment with a trypsin inhibitor, camostat mesilate, against the reflux esophagitis after distal gastrectomy reconstructed with Billroth-I anastomosis...
  6. ncbi request reprint CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers
    Koji Kono
    First Department of Surgery, University of Yamanashi, 1110 Shimokato, Tamaho, 409 3898 Yamanashi, Japan
    Cancer Immunol Immunother 55:1064-71. 2006
    ..In the present study, we evaluated the prevalence of CD4(+)CD25high T regs in PBMCs from patients with gastric and esophageal cancers in relation to the clinical outcome...
  7. ncbi request reprint Transient bloodletting of the short gastric vein in the reconstructed gastric tube improves gastric microcirculation during esophagectomy
    Koji Kono
    Department of Surgery, University of Yamanashi, 1110 Shimokato, 409 3898, Yamanashi, Japan
    World J Surg 31:780-4; discussion 785-6. 2007
    ..In order to improve the congestive status, we developed a novel and easy surgical procedure of transient bloodletting from the short gastric vein after making a gastric tube during esophagectomy, and evaluated tissue blood flow...
  8. ncbi request reprint Evaluation of VEGF and VEGF-C expression in gastric cancer cells producing alpha-fetoprotein
    Shigeo Kamei
    First Department of Surgery, Yamanashi Medical University, 1110 Tamaho, Yamanashi 409 3898, Japan
    J Gastroenterol 38:540-7. 2003
    ....
  9. ncbi request reprint Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma
    Yoshihiko Kawaguchi
    First Department of Surgery, University of Yamanashi, Yamanashi 409 3898, Japan
    Int J Cancer 120:781-7. 2007
    ..In conclusion, Cetuximab was able to induce ADCC against EGFR-expressing esophageal SCC. Some modalities aiming at enhancing the Cetuximab-mediated ADCC may be necessary for successful Cetuximab treatment of patients with esophageal SCC...
  10. ncbi request reprint Distribution of CD4+CD25high regulatory T-cells in tumor-draining lymph nodes in patients with gastric cancer
    Hiromichi Kawaida
    First Department of Surgery, University of Yamanashi, 1110 Shimokato, Tamaho, Yamanashi 409 3898, Japan
    J Surg Res 124:151-7. 2005
    ..In the present study, we evaluated the prevalence of CD4+CD25high T-regs in tumor-draining lymph nodes in patients with gastric cancers...
  11. ncbi request reprint Non-incidental coamplification of Myc and ERBB2, and Myc and EGFR, in gastric adenocarcinomas
    Fumihiko Mitsui
    Department of Pathology, School of Medicine, University of Yamanashi, Yamanashi, Japan
    Mod Pathol 20:622-31. 2007
    ..We propose that the non-incidental coamplification of Myc and either ERBB2 or EGFR occurred through translocation and subsequent rearrangement...
  12. ncbi request reprint Clinicopathologic features of gastric cancers producing alpha-fetoprotein
    Koji Kono
    First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan
    Dig Surg 19:359-65; discussion 365. 2002
    ..The purpose of the present study was to clarify the clinicopathological features of AFP-producing gastric cancers, in particular characteristics of liver metastasis, and to evaluate treatment of these cancers...
  13. ncbi request reprint Mechanisms of escape from trastuzumab-mediated ADCC in esophageal squamous cell carcinoma: relation to susceptibility to perforin-granzyme
    Yoshihiko Kawaguchi
    First Department of Surgery, University of Yamanashi, Chuo City, Yamanashi 409 3898, Japan
    Anticancer Res 29:2137-46. 2009
    ..In the present study, the mechanisms of escape from trastuzumab-mediated ADCC were elucidated using esophageal squamous cell carcinoma (SCC) cell clones...
  14. doi request reprint Detection of novel cancer-testis antigen-specific T-cell responses in TIL, regional lymph nodes, and PBL in patients with esophageal squamous cell carcinoma
    Yoshiki Mizukami
    First Department of Surgery, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi 409 3898, Japan
    Cancer Sci 99:1448-54. 2008
    ....
  15. ncbi request reprint Substitution analog peptide derived from HER-2 can efficiently induce HER-2-specific, HLA-A24 restricted CTLs
    Kousaku Mimura
    First Department of Surgery, University of Yamanashi, 1110 Tamaho, 409 3898 Yamanashi, Japan
    Cancer Immunol Immunother 55:1358-66. 2006
    ....
  16. ncbi request reprint Characteristic alteration of monocytes with increased intracellular IL-10 and IL-12 in patients with advanced-stage gastric cancer
    Hidemitsu Sugai
    First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
    J Surg Res 116:277-87. 2004
    ..These observations encouraged us to investigate monocytes status in cancer-bearing hosts...
  17. ncbi request reprint c-Met expression in a gastric cancer cell line producing alpha-fetoprotein
    Hideki Amemiya
    First Department of Surgery, Yamanashi Medical University, 1110 Shimokato, Tamaho, Nakakoma, Yamanashi 409 3898, Japan
    Surg Today 34:115-22. 2004
    ..We previously reported a higher frequency of c-Met protein expression and high proliferative status in gastric cancers producing alpha-fetoprotein (AFP) than in those not producing AFP...
  18. ncbi request reprint Vascular endothelial growth factor inhibits maturation of dendritic cells induced by lipopolysaccharide, but not by proinflammatory cytokines
    Akihiro Takahashi
    First Department of Surgery, University of Yamanashi, 1110 Shimokato, 409 3898 Tamaho, Yamanashi, Japan
    Cancer Immunol Immunother 53:543-50. 2004
    ..It has been shown that the function of DCs is impaired and their population decreased in a cancer-bearing host. In the present study, we investigated the mechanism of down-regulation of DCs in a cancer-bearing host...
  19. ncbi request reprint Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers
    Fumiko Ichihara
    First Department of Surgery, University of Yamanashi, Yamanashi 409 3898, Japan
    Clin Cancer Res 9:4404-8. 2003
    ..In the present study, we evaluated the prevalence of T-regs in peripheral blood and TILs in patients with gastric and esophageal cancers...
  20. ncbi request reprint Trastuzumab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinoma
    Kousaku Mimura
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    Clin Cancer Res 11:4898-904. 2005
    ....
  21. ncbi request reprint A newly identified MAGE-3-derived, HLA-A24-restricted peptide is naturally processed and presented as a CTL epitope on MAGE-3-expressing gastrointestinal cancer cells
    Naoto Miyagawa
    First Department of Surgery, University of Yamanashi, Japan
    Oncology 70:54-62. 2006
    ..In the present study, we defined a new MAGE-3 derived, HLA-A24-binding peptide presented as a CTL epitope on gastrointestinal cancer cells...
  22. doi request reprint Lapatinib inhibits receptor phosphorylation and cell growth and enhances antibody-dependent cellular cytotoxicity of EGFR- and HER2-overexpressing esophageal cancer cell lines
    Kousaku Mimura
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    Int J Cancer 129:2408-16. 2011
    ..Cumulatively, the data indicate that Lapatinib has activity in EGFR- and/or HER2-expressing ESCC cells, and the combination therapy of Lapatinib and Cetuximab/Herceptin is a promising strategy in ESCC...
  23. ncbi request reprint Vascular endothelial growth factor partially inhibits the trastuzumab-mediated antibody-dependent cellular cytotoxicity of human monocytes
    Kousaku Mimura
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    Oncology 72:172-80. 2007
    ..In the present study, we investigated whether VEGF affects the antibody-dependent cell-mediated cytotoxicity (ADCC) of human monocytes mediated by trastuzumab...
  24. ncbi request reprint Topoisomerase IIalpha gene amplification in gastric carcinomas: correlation with the HER2 gene. An immunohistochemical, immunoblotting, and multicolor fluorescence in situ hybridization study
    Sammy Yasmin Kanta
    Department of Pathology, School of Medicine, University of Yamanashi, Yamanashi 409 3898, Japan
    Hum Pathol 37:1333-43. 2006
    ..Therefore, results of the current study will provide further insight for the clinical application of anthracycline in gastric cancers...
  25. ncbi request reprint Vascular endothelial growth factor inhibits the function of human mature dendritic cells mediated by VEGF receptor-2
    Kousaku Mimura
    First Department of Surgery, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi 409 3898, Japan
    Cancer Immunol Immunother 56:761-70. 2007
    ..Some modalities aiming at reversing mature-DC dysfunction induced by VEGF will be needed in order to induce the effective antitumor immunity...
  26. ncbi request reprint c-Met expression in gastric cancer with liver metastasis
    Hideki Amemiya
    First Department of Surgery, Yamanashi Medical University, Nakakoma, Yamanashi, Japan
    Oncology 63:286-96. 2002
    ..Moreover, the evaluation of c-Met expression might be a useful indicator of liver metastasis in patients with gastric cancer...
  27. ncbi request reprint The expression of a type II transmembrane serine protease (Seprase) in human gastric carcinoma
    Yoshiyuki Mori
    Department of Pathology, School of Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
    Oncology 67:411-9. 2004
    ..In the present study, the expression of seprase mRNA, protein and its gelatin-degrading activity in human gastric carcinoma were examined to substantiate the potential role of seprase in gastric carcinoma invasion...
  28. ncbi request reprint Dendritic cells pulsed with HER-2/neu-derived peptides can induce specific T-cell responses in patients with gastric cancer
    Koji Kono
    First Department of Surgery, Yamanashi Medical University, Yamanashi, 409 3898 Japan
    Clin Cancer Res 8:3394-400. 2002
    ..In the present study, we described a Phase-1 vaccination trial in gastric cancer patients using dendritic cells (DCs) pulsed with the immunodominant HER-2/neu(p369) peptides...
  29. ncbi request reprint Macrophages in tumor-draining lymph node with different characteristics induce T-cell apoptosis in patients with advanced stage-gastric cancer
    Akihiro Takahashi
    First Department of Surgery, Yamanashi Medical University, Tamaho, Yamanashi, Japan
    Int J Cancer 104:393-9. 2003
    ..Furthermore, the characteristics of MTDL including the capacity of oxygen-burst and intracellular cytokine production were different depending on the disease progression...
  30. doi request reprint H₂O₂ production within tumor microenvironment inversely correlated with infiltration of CD56(dim) NK cells in gastric and esophageal cancer: possible mechanisms of NK cell dysfunction
    Shinichirou Izawa
    First Department of Surgery, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi 409 3898, Japan
    Cancer Immunol Immunother 60:1801-10. 2011
    ..These observations may explain one of the mechanisms behind NK cell dysfunction frequently observed in tumor microenvironments...
  31. doi request reprint CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer
    Yoshiki Mizukami
    First Department of Surgery, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi, Japan
    Int J Cancer 122:2286-93. 2008
    ..In conclusion, CCL17 and CCL22 within the tumor are related to the increased population of Foxp3(+) Tregs, with such an observation occurring in early gastric cancer...
  32. ncbi request reprint Prognostic significance of adoptive immunotherapy with tumor-associated lymphocytes in patients with advanced gastric cancer: a randomized trial
    Koji Kono
    First Department of Surgery, Yamanashi Medical University, 1110 Tamaho, Yamanashi 409 3898, Japan
    Clin Cancer Res 8:1767-71. 2002
    ....
  33. doi request reprint Increased prevalence of tumor-infiltrating regulatory T cells is closely related to their lower sensitivity to H2O2-induced apoptosis in gastric and esophageal cancer
    Shinichirou Izawa
    First Department of Surgery, University of Yamanashi, Kofu and Tamaho, Japan
    Cancer Immunol Immunother 62:161-70. 2013
    ....
  34. ncbi request reprint [Study of monocyte intracellular cytokine and heterogeneity of monocytes in a gastric cancer patient]
    Hidemitsu Sugai
    First Dept of Surgery, Faculty of Medicine, University of Yamanashi
    Gan To Kagaku Ryoho 30:1844-7. 2003
    ..The plasma from the patients with advanced disease could induce increased intracellular IL-10 and IL-12 status in healthy monocytes. The phenomenon was significantly inhibited with neutralizing mAbs specific for VEGF...
  35. ncbi request reprint Impaired antibody-dependent cellular cytotoxicity mediated by herceptin in patients with gastric cancer
    Koji Kono
    First Department of Surgery, Yamanashi Medical University, Japan
    Cancer Res 62:5813-7. 2002
    ..Thus, some modalities such as interleukin 2 treatment aimed at reversing NK dysfunction may be necessary for successful Herceptin treatment of gastric cancer...
  36. ncbi request reprint Expression of high mobility group box chromosomal protein-1 (HMGB-1) in gastric cancer
    Hidenori Akaike
    First Department of Surgery, University of Yamanashi, Yamanashi, Chuo city 409 3898, Japan
    Anticancer Res 27:449-57. 2007
    ..05), although the HMGB-1 expression in cancer cells was not an independent prognostic factor. HMGB-1 expression may be one of the key factors regulating inflammatory reactions within the tumor microenvironment...
  37. ncbi request reprint EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagus
    Mitsuhiko Hanawa
    Department of Pathology, School of Medicine, University of Yamanashi, Japan
    Int J Cancer 118:1173-80. 2006
    ..We assume that combined analyses by immunohistochemistry/FISH would clarify aberrations in protein and gene function, and could help to identify those patients who may benefit from anti-EGFR therapy...
  38. ncbi request reprint Improved quality of life with jejunal pouch reconstruction after total gastrectomy
    Koji Kono
    First Department of Surgery, Yamanashi Medical University, 1110 Tamaho, 409 3898, Yamanashi, Japan
    Am J Surg 185:150-4. 2003
    ....
  39. doi request reprint Immunonutritional diet modulates natural killer cell activation and Th17 cell distribution in patients with gastric and esophageal cancer
    Takanori Maruyama
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    Nutrition 27:146-52. 2011
    ....
  40. doi request reprint Distribution of Th17 cells and FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, tumor-draining lymph nodes and peripheral blood lymphocytes in patients with gastric cancer
    Takanori Maruyama
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    Cancer Sci 101:1947-54. 2010
    ....
  41. ncbi request reprint Correlation of vascular endothelial growth factor-C expression with tumor-infiltrating dendritic cells in gastric cancer
    Akihiro Takahashi
    First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan
    Oncology 62:121-7. 2002
    ..26, p < 0.05). We suggest that VEGF-C produced by cancer causes DCs to become dysfunctional. This may be one of the ways that cancers evade immunosurveillance...
  42. pmc Multicenter, phase II clinical trial of cancer vaccination for advanced esophageal cancer with three peptides derived from novel cancer-testis antigens
    Koji Kono
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    J Transl Med 10:141. 2012
    ....
  43. ncbi request reprint Frequencies of HER-2/neu overexpression relating to HLA haplotype in patients with gastric cancer
    Koji Kono
    First Department of Surgery, Yamanashi Medical University, Yamanashi 409 3898, Japan
    Int J Cancer 98:216-20. 2002
    ..The candidate for HER-2/neu-based immunotherapy with HLA-A2-restricted peptides represent a very limited population of Japanese patients...
  44. ncbi request reprint Lapatinib enhances herceptin-mediated antibody-dependent cellular cytotoxicity by up-regulation of cell surface HER2 expression
    Takanori Maruyama
    First Department of Surgery, University of Yamanashi, Yamanashi, Japan
    Anticancer Res 31:2999-3005. 2011
    ....
  45. ncbi request reprint Status of c-erbB-2 in gastric adenocarcinoma: a comparative study of immunohistochemistry, fluorescence in situ hybridization and enzyme-linked immuno-sorbent assay
    Takuo Takehana
    Department of Pathology, Yamanashi Medical University, Yamanashi, Japan
    Int J Cancer 98:833-7. 2002
    ..Patients having gastric adenocarcinoma with c-erbB-2 amplification are potential candidates for a new adjuvant therapy using humanized monoclonal antibody...
  46. doi request reprint Immunogenic tumor cell death induced by chemoradiotherapy in patients with esophageal squamous cell carcinoma
    Yoshiyuki Suzuki
    Department of Surgery, National University of Singapore, Cancer Science Institute of Singapore, Singapore
    Cancer Res 72:3967-76. 2012
    ..Together, our findings indicate that chemoradiation induces tumor antigen-specific T-cell responses, and HMGB1 production is related to clinical outcome after chemoradiation...
  47. ncbi request reprint Oncofetal antigen 5T4 expression as a prognostic factor in patients with gastric cancer
    Hiroshi Naganuma
    First Department of Surgery, Yamanashi Medical University, Japan
    Anticancer Res 22:1033-8. 2002
    ..Antigen 5T4 is reported to be expressed only on trophoblasts and neoplastic cells and would be a potentially useful marker for neoplastic cells...
  48. ncbi request reprint Treatment of abdominal malignancy invading the vena cava: a report of seven cases
    Shunya Shindo
    Second Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi 409 3898, Japan
    Surg Today 37:685-9. 2007
    ..These cases are described, with particular focus on the management of the major vessels...
  49. ncbi request reprint Preferential cell death of CD8+ effector memory (CCR7-CD45RA-) T cells by hydrogen peroxide-induced oxidative stress
    Akihiro Takahashi
    Department of Oncology and Pathology, Immune and Gene Therapy Laboratory, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
    J Immunol 174:6080-7. 2005
    ..This study suggests that oxidative stress in cancer patients can be disadvantageous for T cell-based adoptive cell transfer therapies, since effector memory T cells are the primary phenotype of the cells administered...
  50. ncbi request reprint Immunization with heat shock protein 70 from methylcholanthrene-induced sarcomas induces tumor protection correlating with in vitro T cell responses
    Anne Marie T Ciupitu
    Department of Oncology Pathology, Karolinska Institute, R8 01, 171 76 Stockholm, Sweden
    Cancer Immunol Immunother 51:163-70. 2002
    ..We therefore conclude that hsp70 immunization can lead to protection against the tumor it was purified from, with a low risk of eliciting neutralizing antibodies that could affect further immunizations...
  51. ncbi request reprint [Generation of HER2 specific, HLA-A24 restricted CTLs derived from gastric cancer patients]
    Kousaku Mimura
    First Dept of Surgery, Yamanashi University
    Gan To Kagaku Ryoho 30:1802-4. 2003
    ..In conclusion, we were able to identified HER2 peptide epitopes restricted by HLA-A24, suggesting that these epitopes will be new targets for cancer vaccine therapy...
  52. ncbi request reprint A case of metastatic breast cancer with outgrowth of HER2-negative cells after eradication of HER2-positive cells by humanized anti-HER2 monoclonal antibody (trastuzumab) combined with docetaxel
    Kazuyoshi Kunitomo
    Department of Pathology, Yamanashi Medical University, Japan
    Hum Pathol 35:379-81. 2004
    ..However, in the pleural effusion, the effect of trastuzumab was more specific to HER2-amplified cells and caused outgrowth of cancer cells lacking expression of HER2 receptors...
  53. ncbi request reprint Expression of epidermal growth factor receptor in gastric carcinomas
    Takuo Takehana
    Department of Pathology, Yamanashi Medical University, Japan
    Clin Gastroenterol Hepatol 1:438-45. 2003
    ..This was achieved by determining the frequency of increased epidermal growth factor receptor expression in gastric cancers and investigating the relationship between protein overexpression and gene amplification...