Research Topics
Genomes and GenesSpecies | Koji KonoSummaryAffiliation: University of Yamanashi Country: Japan Publications
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Publications
Trypsin activity and bile acid concentrations in the esophagus after distal gastrectomyKoji Kono
First Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Tamaho, Yamanashi, 409 3898, Japan
Dig Dis Sci 51:1159-64. 2006....- Trastuzumab (Herceptin) enhances class I-restricted antigen presentation recognized by HER-2/neu-specific T cytotoxic lymphocytesKoji Kono
First Department of Surgery, and Department of Neurosurgery, University of Yamanashi, Yamanashi, Japan
Clin Cancer Res 10:2538-44. 2004..One of the actions of Herceptin includes the internalization and degradation of HER-2, which might increase the amount of HER-2-derived peptides available for loading to MHC class I... 
Vaccination with multiple peptides derived from novel cancer-testis antigens can induce specific T-cell responses and clinical responses in advanced esophageal cancerKoji Kono
First Department of Surgery, University of Yamanashi, Yamanashi, Japan
Cancer Sci 100:1502-9. 2009..5 months. The cancer vaccine therapy using these three peptides demonstrated satisfactory safety and good immunogenicity as well as promising disease control rate, and therefore warrants further clinical studies...- Protein-bound polysaccharide K partially prevents apoptosis of circulating T cells induced by anti-cancer drug S-1 in patients with gastric cancerKoji Kono
First Department of Surgery, University of Yamanashi, Yamanashi, Japan
Oncology 74:143-9. 2008.... - Oral trypsin inhibitor can improve reflux esophagitis after distal gastrectomy concomitant with decreased trypsin activityKoji Kono
First Department of Surgery, University of Yamanashi, 1110 Tamaho, Yamanashi 409 3898, Japan
Am J Surg 190:412-7. 2005..We investigated the clinical usefulness and antitrypsin activity after treatment with a trypsin inhibitor, camostat mesilate, against the reflux esophagitis after distal gastrectomy reconstructed with Billroth-I anastomosis... - CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancersKoji Kono
First Department of Surgery, University of Yamanashi, 1110 Shimokato, Tamaho, 409 3898 Yamanashi, Japan
Cancer Immunol Immunother 55:1064-71. 2006..In the present study, we evaluated the prevalence of CD4(+)CD25high T regs in PBMCs from patients with gastric and esophageal cancers in relation to the clinical outcome... - Transient bloodletting of the short gastric vein in the reconstructed gastric tube improves gastric microcirculation during esophagectomyKoji Kono
Department of Surgery, University of Yamanashi, 1110 Shimokato, 409 3898, Yamanashi, Japan
World J Surg 31:780-4; discussion 785-6. 2007..In order to improve the congestive status, we developed a novel and easy surgical procedure of transient bloodletting from the short gastric vein after making a gastric tube during esophagectomy, and evaluated tissue blood flow... - Evaluation of VEGF and VEGF-C expression in gastric cancer cells producing alpha-fetoproteinShigeo Kamei
First Department of Surgery, Yamanashi Medical University, 1110 Tamaho, Yamanashi 409-3898, Japan
J Gastroenterol 38:540-7. 2003..The microvessel density was higher in the AFP(+) group than in the AFP(-) group (P < 0.05). CONCLUSIONS: A higher expression of VEGF-C might be one explanation for the poorer prognosis of AFP-producing gastric cancers... - Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinomaYoshihiko Kawaguchi
First Department of Surgery, University of Yamanashi, Yamanashi 409 3898, Japan
Int J Cancer 120:781-7. 2007..In conclusion, Cetuximab was able to induce ADCC against EGFR-expressing esophageal SCC. Some modalities aiming at enhancing the Cetuximab-mediated ADCC may be necessary for successful Cetuximab treatment of patients with esophageal SCC... - Distribution of CD4+CD25high regulatory T-cells in tumor-draining lymph nodes in patients with gastric cancerHiromichi Kawaida
First Department of Surgery, University of Yamanashi, 1110 Shimokato, Tamaho, Yamanashi 409-3898, Japan
J Surg Res 124:151-7. 2005..The increased prevalence of T-regs may be one of the explanations for impaired cell-mediated immunity in cancer-bearing hosts... - Non-incidental coamplification of Myc and ERBB2, and Myc and EGFR, in gastric adenocarcinomasFumihiko Mitsui
Department of Pathology, School of Medicine, University of Yamanashi, Yamanashi, Japan
Mod Pathol 20:622-31. 2007..We propose that the non-incidental coamplification of Myc and either ERBB2 or EGFR occurred through translocation and subsequent rearrangement... - Clinicopathologic features of gastric cancers producing alpha-fetoproteinKoji Kono
First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan
Dig Surg 19:359-65; discussion 365. 2002..The purpose of the present study was to clarify the clinicopathological features of AFP-producing gastric cancers, in particular characteristics of liver metastasis, and to evaluate treatment of these cancers... - Mechanisms of escape from trastuzumab-mediated ADCC in esophageal squamous cell carcinoma: relation to susceptibility to perforin-granzymeYoshihiko Kawaguchi
First Department of Surgery, University of Yamanashi, Chuo City, Yamanashi 409 3898, Japan
Anticancer Res 29:2137-46. 2009..In the present study, the mechanisms of escape from trastuzumab-mediated ADCC were elucidated using esophageal squamous cell carcinoma (SCC) cell clones... - Detection of novel cancer-testis antigen-specific T-cell responses in TIL, regional lymph nodes, and PBL in patients with esophageal squamous cell carcinomaYoshiki Mizukami
First Department of Surgery, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi 409 3898, Japan
Cancer Sci 99:1448-54. 2008.... - Substitution analog peptide derived from HER-2 can efficiently induce HER-2-specific, HLA-A24 restricted CTLsKousaku Mimura
First Department of Surgery, University of Yamanashi, 1110 Tamaho, 409-3898 Yamanashi, Japan
Cancer Immunol Immunother 55:1358-66. 2006.... - Characteristic alteration of monocytes with increased intracellular IL-10 and IL-12 in patients with advanced-stage gastric cancerHidemitsu Sugai
First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
J Surg Res 116:277-87. 2004.... - c-Met expression in a gastric cancer cell line producing alpha-fetoproteinHideki Amemiya
First Department of Surgery, Yamanashi Medical University, 1110 Shimokato, Tamaho, Nakakoma, Yamanashi 409-3898, Japan
Surg Today 34:115-22. 2004..CONCLUSIONS: The AME-1 cell line may be a useful model for elucidating aggressive behavior, especially related to regulation of the c-Met/HGF system, in AFP-producing gastric cancers... - Vascular endothelial growth factor inhibits maturation of dendritic cells induced by lipopolysaccharide, but not by proinflammatory cytokinesAkihiro Takahashi
First Department of Surgery, University of Yamanashi, 1110 Shimokato, 409-3898 Tamaho, Yamanashi, Japan
Cancer Immunol Immunother 53:543-50. 2004..CONCLUSIONS: These findings show that the inhibition of DC maturation by VEGF differs depending on the maturation status of the DCs... - Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancersFumiko Ichihara
First Department of Surgery, University of Yamanashi, Yamanashi 409-3898, Japan
Clin Cancer Res 9:4404-8. 2003..CONCLUSIONS: The populations of CD4+/CD25+ T-regs in peripheral blood and TILs in patients with gastric and esophageal cancers were significantly higher in comparison with those in healthy donors or normal mucosa... - Trastuzumab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinomaKousaku Mimura
First Department of Surgery, University of Yamanashi, Yamanashi, Japan
Clin Cancer Res 11:4898-904. 2005.... - A newly identified MAGE-3-derived, HLA-A24-restricted peptide is naturally processed and presented as a CTL epitope on MAGE-3-expressing gastrointestinal cancer cellsNaoto Miyagawa
First Department of Surgery, University of Yamanashi, Japan
Oncology 70:54-62. 2006..In the present study, we defined a new MAGE-3 derived, HLA-A24-binding peptide presented as a CTL epitope on gastrointestinal cancer cells... - Lapatinib inhibits receptor phosphorylation and cell growth and enhances antibody-dependent cellular cytotoxicity of EGFR- and HER2-overexpressing esophageal cancer cell linesKousaku Mimura
First Department of Surgery, University of Yamanashi, Yamanashi, Japan
Int J Cancer 129:2408-16. 2011..Cumulatively, the data indicate that Lapatinib has activity in EGFR- and/or HER2-expressing ESCC cells, and the combination therapy of Lapatinib and Cetuximab/Herceptin is a promising strategy in ESCC... - Vascular endothelial growth factor partially inhibits the trastuzumab-mediated antibody-dependent cellular cytotoxicity of human monocytesKousaku Mimura
First Department of Surgery, University of Yamanashi, Yamanashi, Japan
Oncology 72:172-80. 2007..In the present study, we investigated whether VEGF affects the antibody-dependent cell-mediated cytotoxicity (ADCC) of human monocytes mediated by trastuzumab... - Topoisomerase IIalpha gene amplification in gastric carcinomas: correlation with the HER2 gene. An immunohistochemical, immunoblotting, and multicolor fluorescence in situ hybridization studySammy Yasmin Kanta
Department of Pathology, School of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan
Hum Pathol 37:1333-43. 2006..Therefore, results of the current study will provide further insight for the clinical application of anthracycline in gastric cancers... - Vascular endothelial growth factor inhibits the function of human mature dendritic cells mediated by VEGF receptor-2Kousaku Mimura
First Department of Surgery, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi 409 3898, Japan
Cancer Immunol Immunother 56:761-70. 2007..Some modalities aiming at reversing mature-DC dysfunction induced by VEGF will be needed in order to induce the effective antitumor immunity... - c-Met expression in gastric cancer with liver metastasisHideki Amemiya
First Department of Surgery, Yamanashi Medical University, Nakakoma, Yamanashi, Japan
Oncology 63:286-96. 2002..Moreover, the evaluation of c-Met expression might be a useful indicator of liver metastasis in patients with gastric cancer... - The expression of a type II transmembrane serine protease (Seprase) in human gastric carcinomaYoshiyuki Mori
Department of Pathology, School of Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
Oncology 67:411-9. 2004..In the present study, the expression of seprase mRNA, protein and its gelatin-degrading activity in human gastric carcinoma were examined to substantiate the potential role of seprase in gastric carcinoma invasion... - Dendritic cells pulsed with HER-2/neu-derived peptides can induce specific T-cell responses in patients with gastric cancerKoji Kono
First Department of Surgery, Yamanashi Medical University, Yamanashi, 409 3898 Japan
Clin Cancer Res 8:3394-400. 2002..In the present study, we described a Phase-1 vaccination trial in gastric cancer patients using dendritic cells (DCs) pulsed with the immunodominant HER-2/neu(p369) peptides... - Macrophages in tumor-draining lymph node with different characteristics induce T-cell apoptosis in patients with advanced stage-gastric cancerAkihiro Takahashi
First Department of Surgery, Yamanashi Medical University, Tamaho, Yamanashi, Japan
Int J Cancer 104:393-9. 2003..Furthermore, the characteristics of MTDL including the capacity of oxygen-burst and intracellular cytokine production were different depending on the disease progression... - H₂O₂ production within tumor microenvironment inversely correlated with infiltration of CD56(dim) NK cells in gastric and esophageal cancer: possible mechanisms of NK cell dysfunctionShinichirou Izawa
First Department of Surgery, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi 409 3898, Japan
Cancer Immunol Immunother 60:1801-10. 2011..These observations may explain one of the mechanisms behind NK cell dysfunction frequently observed in tumor microenvironments... - CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancerYoshiki Mizukami
First Department of Surgery, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi, Japan
Int J Cancer 122:2286-93. 2008..In conclusion, CCL17 and CCL22 within the tumor are related to the increased population of Foxp3(+) Tregs, with such an observation occurring in early gastric cancer... - Prognostic significance of adoptive immunotherapy with tumor-associated lymphocytes in patients with advanced gastric cancer: a randomized trialKoji Kono
First Department of Surgery, Yamanashi Medical University, 1110 Tamaho, Yamanashi 409 3898, Japan
Clin Cancer Res 8:1767-71. 2002.... - Increased prevalence of tumor-infiltrating regulatory T cells is closely related to their lower sensitivity to H2O2-induced apoptosis in gastric and esophageal cancerShinichirou Izawa
First Department of Surgery, University of Yamanashi, Kofu and Tamaho, Japan
Cancer Immunol Immunother 62:161-70. 2013.... - [Study of monocyte intracellular cytokine and heterogeneity of monocytes in a gastric cancer patient]Hidemitsu Sugai
First Dept. of Surgery, Faculty of Medicine, University of Yamanashi
Gan To Kagaku Ryoho 30:1844-7. 2003..The plasma from the patients with advanced disease could induce increased intracellular IL-10 and IL-12 status in healthy monocytes. The phenomenon was significantly inhibited with neutralizing mAbs specific for VEGF... - Impaired antibody-dependent cellular cytotoxicity mediated by herceptin in patients with gastric cancerKoji Kono
First Department of Surgery, Yamanashi Medical University, Japan
Cancer Res 62:5813-7. 2002..Thus, some modalities such as interleukin 2 treatment aimed at reversing NK dysfunction may be necessary for successful Herceptin treatment of gastric cancer... - Expression of high mobility group box chromosomal protein-1 (HMGB-1) in gastric cancerHidenori Akaike
First Department of Surgery, University of Yamanashi, Yamanashi, Chuo city 409 3898, Japan
Anticancer Res 27:449-57. 2007..05), although the HMGB-1 expression in cancer cells was not an independent prognostic factor. HMGB-1 expression may be one of the key factors regulating inflammatory reactions within the tumor microenvironment... - EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagusMitsuhiko Hanawa
Department of Pathology, School of Medicine, University of Yamanashi, Japan
Int J Cancer 118:1173-80. 2006..We assume that combined analyses by immunohistochemistry/FISH would clarify aberrations in protein and gene function, and could help to identify those patients who may benefit from anti-EGFR therapy... - Improved quality of life with jejunal pouch reconstruction after total gastrectomyKoji Kono
First Department of Surgery, Yamanashi Medical University, 1110 Tamaho, 409 3898, Yamanashi, Japan
Am J Surg 185:150-4. 2003.... - Immunonutritional diet modulates natural killer cell activation and Th17 cell distribution in patients with gastric and esophageal cancerTakanori Maruyama
First Department of Surgery, University of Yamanashi, Yamanashi, Japan
Nutrition 27:146-52. 2011.... - Distribution of Th17 cells and FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, tumor-draining lymph nodes and peripheral blood lymphocytes in patients with gastric cancerTakanori Maruyama
First Department of Surgery, University of Yamanashi, Yamanashi, Japan
Cancer Sci 101:1947-54. 2010.... - Correlation of vascular endothelial growth factor-C expression with tumor-infiltrating dendritic cells in gastric cancerAkihiro Takahashi
First Department of Surgery, Yamanashi Medical University, Yamanashi, Japan
Oncology 62:121-7. 2002..26, p < 0.05). We suggest that VEGF-C produced by cancer causes DCs to become dysfunctional. This may be one of the ways that cancers evade immunosurveillance... 
Multicenter, phase II clinical trial of cancer vaccination for advanced esophageal cancer with three peptides derived from novel cancer-testis antigensKoji Kono
First Department of Surgery, University of Yamanashi, Yamanashi, Japan
J Transl Med 10:141. 2012....- Frequencies of HER-2/neu overexpression relating to HLA haplotype in patients with gastric cancerKoji Kono
First Department of Surgery, Yamanashi Medical University, Yamanashi 409 3898, Japan
Int J Cancer 98:216-20. 2002..The candidate for HER-2/neu-based immunotherapy with HLA-A2-restricted peptides represent a very limited population of Japanese patients... - Lapatinib enhances herceptin-mediated antibody-dependent cellular cytotoxicity by up-regulation of cell surface HER2 expressionTakanori Maruyama
First Department of Surgery, University of Yamanashi, Yamanashi, Japan
Anticancer Res 31:2999-3005. 2011.... - Status of c-erbB-2 in gastric adenocarcinoma: a comparative study of immunohistochemistry, fluorescence in situ hybridization and enzyme-linked immuno-sorbent assayTakuo Takehana
Department of Pathology, Yamanashi Medical University, Yamanashi, Japan
Int J Cancer 98:833-7. 2002..Patients having gastric adenocarcinoma with c-erbB-2 amplification are potential candidates for a new adjuvant therapy using humanized monoclonal antibody... - Immunogenic tumor cell death induced by chemoradiotherapy in patients with esophageal squamous cell carcinomaYoshiyuki Suzuki
Department of Surgery, National University of Singapore, Cancer Science Institute of Singapore, Singapore
Cancer Res 72:3967-76. 2012..Together, our findings indicate that chemoradiation induces tumor antigen-specific T-cell responses, and HMGB1 production is related to clinical outcome after chemoradiation... - Oncofetal antigen 5T4 expression as a prognostic factor in patients with gastric cancerHiroshi Naganuma
First Department of Surgery, Yamanashi Medical University, Japan
Anticancer Res 22:1033-8. 2002..05), although multivariate analysis indicated that 5T4 expression was not an independent prognostic factor. CONCLUSION: The assessment of 5T4 expression may be useful in identifying gastric cancer patients with a poor prognosis... - Treatment of abdominal malignancy invading the vena cava: a report of seven casesShunya Shindo
Second Department of Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi 409 3898, Japan
Surg Today 37:685-9. 2007..These cases are described, with particular focus on the management of the major vessels... - Preferential cell death of CD8+ effector memory (CCR7-CD45RA-) T cells by hydrogen peroxide-induced oxidative stressAkihiro Takahashi
Department of Oncology and Pathology, Immune and Gene Therapy Laboratory, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
J Immunol 174:6080-7. 2005..This study suggests that oxidative stress in cancer patients can be disadvantageous for T cell-based adoptive cell transfer therapies, since effector memory T cells are the primary phenotype of the cells administered... - Immunization with heat shock protein 70 from methylcholanthrene-induced sarcomas induces tumor protection correlating with in vitro T cell responsesAnne Marie T Ciupitu
Department of Oncology Pathology, Karolinska Institute, R8 01, 171 76 Stockholm, Sweden
Cancer Immunol Immunother 51:163-70. 2002..We therefore conclude that hsp70 immunization can lead to protection against the tumor it was purified from, with a low risk of eliciting neutralizing antibodies that could affect further immunizations... - [Generation of HER2 specific, HLA-A24 restricted CTLs derived from gastric cancer patients]Kousaku Mimura
First Dept. of Surgery, Yamanashi University
Gan To Kagaku Ryoho 30:1802-4. 2003..In conclusion, we were able to identified HER2 peptide epitopes restricted by HLA-A24, suggesting that these epitopes will be new targets for cancer vaccine therapy... - A case of metastatic breast cancer with outgrowth of HER2-negative cells after eradication of HER2-positive cells by humanized anti-HER2 monoclonal antibody (trastuzumab) combined with docetaxelKazuyoshi Kunitomo
Department of Pathology, Yamanashi Medical University, Japan
Hum Pathol 35:379-81. 2004..However, in the pleural effusion, the effect of trastuzumab was more specific to HER2-amplified cells and caused outgrowth of cancer cells lacking expression of HER2 receptors... - Expression of epidermal growth factor receptor in gastric carcinomasTakuo Takehana
Department of Pathology, Yamanashi Medical University, Japan
Clin Gastroenterol Hepatol 1:438-45. 2003..CONCLUSIONS: Although a high level of overexpression of epidermal growth factor receptor is uncommon in gastric carcinomas, it almost exclusively occurs by gene amplification...