T Konishi

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Overexpression of hRFI inhibits 5-fluorouracil-induced apoptosis in colorectal cancer cells via activation of NF-kappaB and upregulation of BCL-2 and BCL-XL
    T Konishi
    Department of Surgical Oncology, The University of Tokyo, Hongo, Tokyo, Japan
    Oncogene 25:3160-9. 2006
  2. ncbi Elective colon and rectal surgery differ in risk factors for wound infection: results of prospective surveillance
    Tsuyoshi Konishi
    Department of Surgical Oncology, University of Tokyo, Tokyo, Japan
    Ann Surg 244:758-63. 2006
  3. ncbi Prospective surveillance effectively reduced rates of surgical site infection associated with elective colorectal surgery at a university hospital in Japan
    Tsuyoshi Konishi
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Infect Control Hosp Epidemiol 27:526-8. 2006
  4. ncbi High hRFI expression correlates with resistance to fluoropyrimidines in human colon cancer cell lines and in xenografts
    S Sasaki
    Dept of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    J Exp Clin Cancer Res 24:397-403. 2005
  5. ncbi Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence
    S Sasaki
    Dept of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    J Exp Clin Cancer Res 23:507-12. 2004
  6. ncbi Association of histochemical expression of Maackia amurensis leukoagglutinin-positive glycoconjugates with behaviour of human gastric cancer
    W Tang
    Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Histopathology 42:239-45. 2003
  7. ncbi Unusual pressure-induced rupture of colonic volvulus in a patient with long-term corticosteroid therapy
    T Tanaka
    Department of Surgical Oncology, University of Tokyo, Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Acta Gastroenterol Belg 71:339-41. 2008
  8. ncbi Effect of age on the relationship between gastric cancer and Helicobacter pylori. Tokyo Research Group of Prevention for Gastric Cancer
    S Kikuchi
    Department of Epidemiology and Environmental Health, Juntendo University School of Medicine, Tokyo, Japan
    Jpn J Cancer Res 91:774-9. 2000
  9. ncbi Localization of N-myc downstream-regulated gene 1 in gastric cancer tissue
    Y Inagaki
    Hepato Biliary Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, and International University of Health and Welfare Mita Hospital, Tokyo 113 8655, Japan
    Dig Liver Dis 41:96-103. 2009
  10. ncbi Gene expression signature and the prediction of ulcerative colitis-associated colorectal cancer by DNA microarray
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Clin Cancer Res 13:415-20. 2007

Detail Information

Publications24

  1. ncbi Overexpression of hRFI inhibits 5-fluorouracil-induced apoptosis in colorectal cancer cells via activation of NF-kappaB and upregulation of BCL-2 and BCL-XL
    T Konishi
    Department of Surgical Oncology, The University of Tokyo, Hongo, Tokyo, Japan
    Oncogene 25:3160-9. 2006
    ..hRFI might be a novel therapeutic target for gene therapy in colorectal cancer...
  2. ncbi Elective colon and rectal surgery differ in risk factors for wound infection: results of prospective surveillance
    Tsuyoshi Konishi
    Department of Surgical Oncology, University of Tokyo, Tokyo, Japan
    Ann Surg 244:758-63. 2006
    ..The objective of this study was to clarify the incidence and risk factors for developing incisional surgical site infection (SSI) in both elective colon and rectal surgery...
  3. ncbi Prospective surveillance effectively reduced rates of surgical site infection associated with elective colorectal surgery at a university hospital in Japan
    Tsuyoshi Konishi
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Infect Control Hosp Epidemiol 27:526-8. 2006
    ..5% to 17.8% of surgeries. Japan should both recognize the importance of broader surveillance for surgical site infection and establish its own nationwide surveillance database...
  4. ncbi High hRFI expression correlates with resistance to fluoropyrimidines in human colon cancer cell lines and in xenografts
    S Sasaki
    Dept of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    J Exp Clin Cancer Res 24:397-403. 2005
    ..This evidence suggests that hRFI may be a marker predicting the response to fluorouracil derived chemotherapeutic agents and that the reduction of the expression level of hRFI might improve the outcome of chemotherapy...
  5. ncbi Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence
    S Sasaki
    Dept of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    J Exp Clin Cancer Res 23:507-12. 2004
    ..This evidence suggests that hRFI may act as an oncogenic molecule affecting the apoptotic pathway...
  6. ncbi Association of histochemical expression of Maackia amurensis leukoagglutinin-positive glycoconjugates with behaviour of human gastric cancer
    W Tang
    Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Histopathology 42:239-45. 2003
    ..To investigate the relationship between sialylation of glycoconjugates and clinicopathological characteristics of gastric cancer...
  7. ncbi Unusual pressure-induced rupture of colonic volvulus in a patient with long-term corticosteroid therapy
    T Tanaka
    Department of Surgical Oncology, University of Tokyo, Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Acta Gastroenterol Belg 71:339-41. 2008
    ..As a result, we came to believe that the fragility of the colonic wall, caused by the patient's long-term use of corticosteroid, had lowered the threshold for pressure-induced colonic rupture...
  8. ncbi Effect of age on the relationship between gastric cancer and Helicobacter pylori. Tokyo Research Group of Prevention for Gastric Cancer
    S Kikuchi
    Department of Epidemiology and Environmental Health, Juntendo University School of Medicine, Tokyo, Japan
    Jpn J Cancer Res 91:774-9. 2000
    ..Possible mechanisms through which H. pylori exerts pathogenic effects are continuous inflammation in adulthood and / or irreversible damage to gastric mucosa in childhood or the teenage years...
  9. ncbi Localization of N-myc downstream-regulated gene 1 in gastric cancer tissue
    Y Inagaki
    Hepato Biliary Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, and International University of Health and Welfare Mita Hospital, Tokyo 113 8655, Japan
    Dig Liver Dis 41:96-103. 2009
    ..This study sought to investigate the clinicopathological significance of N-myc downstream-regulated gene 1 and p53 expression in gastric cancer tissue...
  10. ncbi Gene expression signature and the prediction of ulcerative colitis-associated colorectal cancer by DNA microarray
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Clin Cancer Res 13:415-20. 2007
    ..Ulcerative colitis (UC) is associated with a high risk of colorectal cancer. To identify genes that could predict the development of cancer in UC, we conducted a DNA microarray analysis using nonneoplastic rectal mucosa of UC patients...
  11. ncbi Prognosis and risk factors of metastasis in colorectal carcinoids: results of a nationwide registry over 15 years
    Tsuyoshi Konishi
    Department of Surgical Oncology, University of Tokyo, Tokyo, Japan
    Gut 56:863-8. 2007
    ..In addition, no global consensus has been established on the crucial determinants of metastasis in colorectal carcinoids...
  12. ncbi [Expression of hRFI in digestive system cancer]
    Shin Sasaki
    Department of Surgical Oncology, University of Tokyo
    Nippon Rinsho 61:242-6. 2003
  13. ncbi Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer
    Dai Shida
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Lab Invest 84:1352-62. 2004
    ..These results suggested that alteration of LPA receptor expression might be an important event in the development of colorectal cancer, and therefore, LPA and its receptors could be a chemopreventive target against colorectal cancer...
  14. ncbi hRFI overexpressed in HCT116 cells modulates Bcl-2 family proteins when treated with 5-fluorouracil
    Shin Sasaki
    Department of Surgical Oncology, The University of Tokyo, Hongo, Tokyo 113 8655, Japan
    Oncol Rep 15:1293-8. 2006
    ..Such evidence suggests that the modulation of Bcl-2 family proteins seen in 5-FU treatment plays an important role in the anti-apoptotic function of HCT116/hRFI cells...
  15. ncbi Risk factors for anastomotic leakage after surgery for colorectal cancer: results of prospective surveillance
    Tsuyoshi Konishi
    Department of Surgical Oncology, University of Tokyo, Tokyo, Japan
    J Am Coll Surg 202:439-44. 2006
    ..Surgeons should be aware of such high-risk patients, which would help them to decide whether to create a diversion stoma during surgery...
  16. ncbi Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells
    Dai Shida
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
    Exp Cell Res 301:168-78. 2004
    ..Our results indicate that LPA regulates the migration of gastric cancer cells in a receptor-specific manner and suggest that the expression pattern of LPA receptors may affect the metastatic behavior of gastric cancer...
  17. ncbi Diffuse expression of hRFI is correlated with blood vessel invasion in gastric carcinoma
    Shin Sasaki
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Jpn J Clin Oncol 34:584-7. 2004
    ..Furthermore, its diffuse expression is associated with colorectal carcinogenesis. However, hRFI expression in gastric carcinomas has not been evaluated so far...
  18. ncbi Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells
    Tsuyoshi Konishi
    Department of Surgical Oncology, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    Anticancer Res 25:2737-41. 2005
    ..Growth in the normal medium was not altered. CONCLUSION: hRFI plays an important role in the resistance to chemotherapeutic agent-induced apoptosis in colorectal cancer cells...
  19. ncbi Overexpression of hRFI (human ring finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells
    Tsuyoshi Konishi
    Department of Surgical Oncology, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Cancer Ther 4:743-50. 2005
    ..Considering the progressive increase of hRFI expression in the advance of the colorectal adenoma-carcinoma sequence, hRFI is one of the important players in colorectal carcinogenesis through its effect on apoptosis regulation...
  20. ncbi Difference in incidence of colorectal cancer between men and women in Asia
    Tsuyoshi Konishi
    Lancet Oncol 7:104-5. 2006
  21. ncbi Pelvic drainage should be a routine for TME with or without radiation
    Tsuyoshi Konishi
    Ann Surg 243:141-2; author reply 142. 2006
  22. ncbi Toxic megacolon associated with Crohn's disease
    Takeshi Tsuchiya
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Gastrointest Endosc 64:1012-3; discussion 1013. 2006
  23. ncbi Impaction of a rectal foreign body: what is the final approach before surgery?
    Tsuyoshi Konishi
    Dis Colon Rectum 50:262-3; author reply 263. 2007
  24. ncbi Confined progression of cap polyposis along the anastomotic line, implicating the role of inflammatory responses in the pathogenesis
    Tsuyoshi Konishi
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Japan
    Gastrointest Endosc 62:446-7; discussion 447. 2005