Tetsuo Kondo

Summary

Affiliation: University of Yamanashi
Country: Japan

Publications

  1. doi request reprint Unusual thyroid carcinoma with excessive extracellular hyaline globules: a case of "hyalinizing papillary carcinoma"
    Tetsuo Kondo
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, 409 3898, Japan
    Hum Pathol 43:932-8. 2012
  2. ncbi request reprint Mucinous carcinoma (poorly differentiated carcinoma with extensive extracellular mucin deposition) of the thyroid: a case report with immunohistochemical studies
    Tetsuo Kondo
    Department of Pathology, University of Yamanashi, Yamanashi, Japan
    Hum Pathol 36:698-701. 2005
  3. ncbi request reprint Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas
    Tetsuo Kondo
    Department of Pathology, University of Yamanashi, Yamanashi, Japan
    Lab Invest 89:791-9. 2009
  4. ncbi request reprint Enhanced B-Raf protein expression is independent of V600E mutant status in thyroid carcinomas
    Tetsuo Kondo
    Department of Pathology, University of Yamanashi, Chuo, Yamanashi 409 3898, Japan
    Hum Pathol 38:1810-8. 2007
  5. ncbi request reprint Stromal elastosis in papillary thyroid carcinomas
    Tetsuo Kondo
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan
    Hum Pathol 36:474-9. 2005
  6. ncbi request reprint Endocervical adenocarcinomas associated with lobular endocervical glandular hyperplasia: a report of four cases with histochemical and immunohistochemical analyses
    Tetsuo Kondo
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Mod Pathol 18:1199-210. 2005
  7. ncbi request reprint Gastric mucin is expressed in a subset of endocervical tunnel clusters: type A tunnel clusters of gastric phenotype
    T Kondo
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Histopathology 50:843-50. 2007
  8. doi request reprint Polyclonal origin of hormone-producing cell populations evaluated as a direct in situ demonstration in EGFP/BALB/C chimeric mice
    De Fu Ma
    Department of Pathology, University of Yamanashi, Chuo Yamanashi, Japan
    J Endocrinol 207:17-25. 2010
  9. pmc Differential expression of aquaporins and its diagnostic utility in thyroid cancer
    Dongfeng Niu
    Department of Human Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi, Japan
    PLoS ONE 7:e40770. 2012
  10. ncbi request reprint Lobular endocervical glandular hyperplasia as a presumed precursor of cervical adenocarcinoma independent of human papillomavirus infection
    Masatoshi Nara
    Department of Obstetrics and Gynecology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Gynecol Oncol 106:289-98. 2007

Collaborators

Detail Information

Publications45

  1. doi request reprint Unusual thyroid carcinoma with excessive extracellular hyaline globules: a case of "hyalinizing papillary carcinoma"
    Tetsuo Kondo
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, 409 3898, Japan
    Hum Pathol 43:932-8. 2012
    ..Based on these findings, we diagnosed the present tumor as a rare morphological variation of papillary thyroid carcinoma with excessive hyaline globules consisting of basal membrane materials...
  2. ncbi request reprint Mucinous carcinoma (poorly differentiated carcinoma with extensive extracellular mucin deposition) of the thyroid: a case report with immunohistochemical studies
    Tetsuo Kondo
    Department of Pathology, University of Yamanashi, Yamanashi, Japan
    Hum Pathol 36:698-701. 2005
    ..The patient died of multiple metastases 4 years after the initial operation...
  3. ncbi request reprint Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas
    Tetsuo Kondo
    Department of Pathology, University of Yamanashi, Yamanashi, Japan
    Lab Invest 89:791-9. 2009
    ..Our data suggest that epigenetics is involved with inactivation of TTF-1 in thyroid carcinomas, and provide a possible means of using TTF-1 as a target for differentiation-inducing therapy through epigenetic modification...
  4. ncbi request reprint Enhanced B-Raf protein expression is independent of V600E mutant status in thyroid carcinomas
    Tetsuo Kondo
    Department of Pathology, University of Yamanashi, Chuo, Yamanashi 409 3898, Japan
    Hum Pathol 38:1810-8. 2007
    ....
  5. ncbi request reprint Stromal elastosis in papillary thyroid carcinomas
    Tetsuo Kondo
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan
    Hum Pathol 36:474-9. 2005
    ..It is, therefore, reasonable to propose that stromal elastosis is an ancillary feature in the histopathological diagnosis of PTCs...
  6. ncbi request reprint Endocervical adenocarcinomas associated with lobular endocervical glandular hyperplasia: a report of four cases with histochemical and immunohistochemical analyses
    Tetsuo Kondo
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Mod Pathol 18:1199-210. 2005
    ..Histopathological features of the present cases suggest that some endocervical adenocarcinomas may originate from lobular endocervical glandular hyperplasia...
  7. ncbi request reprint Gastric mucin is expressed in a subset of endocervical tunnel clusters: type A tunnel clusters of gastric phenotype
    T Kondo
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Histopathology 50:843-50. 2007
    ..Gastric mucin expression has been demonstrated in a group of endocervical glandular lesions. The aim of this study was to gain further insight into endocervical lesions with a gastric phenotype...
  8. doi request reprint Polyclonal origin of hormone-producing cell populations evaluated as a direct in situ demonstration in EGFP/BALB/C chimeric mice
    De Fu Ma
    Department of Pathology, University of Yamanashi, Chuo Yamanashi, Japan
    J Endocrinol 207:17-25. 2010
    ..Furthermore, we clearly demonstrate that all hormone-producing cell populations are of polyclonal embryonic origin, derived from more than two progenitor cells...
  9. pmc Differential expression of aquaporins and its diagnostic utility in thyroid cancer
    Dongfeng Niu
    Department of Human Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi, Japan
    PLoS ONE 7:e40770. 2012
    ..Little is known of their expression and significance in human thyroid tissues. Thus, we examined the expression of AQP3 and AQP4 in normal, hyperplastic and neoplastic thyroid tissues in conjunction with human thyroid cancer cell lines...
  10. ncbi request reprint Lobular endocervical glandular hyperplasia as a presumed precursor of cervical adenocarcinoma independent of human papillomavirus infection
    Masatoshi Nara
    Department of Obstetrics and Gynecology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Gynecol Oncol 106:289-98. 2007
    ..The aim of this study was to investigate differences in the process of carcinogenesis between adenocarcinoma coexistent with LEGH and conventional adenocarcinoma. And we intend to describe appropriate treatment plans for LEGH in this study...
  11. ncbi request reprint Conservation and alteration of chromosome territory arrangements in thyroid carcinoma cell nuclei
    Shin Ichi Murata
    Department of Pathology, Saitama Medical University International Medical Center, Saitama, Japan
    Thyroid 17:489-96. 2007
    ..These findings indicate that alteration of CT positioning could be related to DNA amplification and, morphologically, may explain the nuclear atypia that accompanies the abnormal chromatin feature...
  12. ncbi request reprint p16INK4a overexpression independent of human papillomavirus infection in lobular endocervical glandular hyperplasia
    Akihiko Hashi
    Department of Obstetrics and Gynecology, and Clinical Laboratory, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
    Int J Gynecol Pathol 25:187-94. 2006
    ..Overall, p16INK4a overexpression was seen in 87.5% of the cases (21/24). HPV DNA was not detected in any of the 24 LEGH cases. These results suggest that p16INK4a overexpression is independent of HPV infection in LEGH...
  13. ncbi request reprint Morphological abstraction of thyroid tumor cell nuclei using morphometry with factor analysis
    Shin Ichi Murata
    Department of Pathology, University of Yamanashi School of Medicine, Nakakoma gun, Yamanashi, Japan
    Microsc Res Tech 61:457-62. 2003
    ..Morphological abstraction by morphometry with factor analysis may provide a practical approach to the detection of the underlying characteristics of nuclear morphology in aspiration biopsy cytology...
  14. doi request reprint Global histone modification of histone H3 in colorectal cancer and its precursor lesions
    Tadao Nakazawa
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409 3898, Japan
    Hum Pathol 43:834-42. 2012
    ..These results suggest that aberration of the global H3K9me2 level is an important epigenetic event in colorectal tumorigenesis and carcinogenesis involved with gene regulation in neoplastic cells through chromatin remodeling...
  15. doi request reprint RET rearrangements and BRAF mutation in undifferentiated thyroid carcinomas having papillary carcinoma components
    Kunio Mochizuki
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan
    Histopathology 57:444-50. 2010
    ..To elucidate the genetic background of anaplastic transformation, RET rearrangements and BRAF mutation were studied in composite undifferentiated carcinomas (UCs) of the thyroid, which are UCs having papillary carcinoma (PC) components...
  16. doi request reprint Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cells
    De Fu Ma
    Department of Pathology, University of Yamanashi, Yamanashi, 409 3898, Japan
    Hum Pathol 41:1550-7. 2010
    ..Our data suggest that this adenosine receptor is a potential therapeutic target for colorectal cancer...
  17. ncbi request reprint RET/PTC rearrangements arising from a small population of papillary thyroid carcinoma cells, possible candidate for passenger mutation
    Tadao Nakazawa
    Department of Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    Virchows Arch 455:35-41. 2009
    ....
  18. doi request reprint Involvement of centrosomes in nuclear irregularity of thyroid carcinoma cells
    Dongfeng Niu
    Department of Human Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409 3898, Japan
    Virchows Arch 455:149-57. 2009
    ..In conclusion, we suggest that cell-to-cell contact may affect nuclear changes such as BLNs and DLNs in cancer cell lines and that centrosomes may be involved in the morphogenetic process of these nuclear changes...
  19. ncbi request reprint Expression of aquaporin 3 (AQP3) in normal and neoplastic lung tissues
    Ya Lan Liu
    Department of Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi 409 3898, Japan
    Hum Pathol 38:171-8. 2007
    ....
  20. ncbi request reprint p16(INK4a) expression analysis as an ancillary tool for cytologic diagnosis of urothelial carcinoma
    Kumiko Nakazawa
    Department of Pathology, University of Hospital, Faculty of Medicine, University of Yamanashi, Yamanashi 409 3898, Japan
    Am J Clin Pathol 132:776-84. 2009
    ..Immunocytologic analysis of p16(INK4a) expression in cytologic samples is a useful ancillary tool for detection of urothelial carcinoma with infiltrating potential...
  21. doi request reprint Intranuclear cytoplasmic inclusion is a significant diagnostic feature for the differentiation of lobular endocervical glandular hyperplasia from minimal deviation adenocarcinoma of the cervix
    Akihiko Hashi
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Yamanashi, Japan
    Diagn Cytopathol 36:535-44. 2008
    ..The presence of an INCI is a good parameter for the diagnosis of LEGH. Cytology is an effective aid in the differentiation of LEGH from MDA...
  22. doi request reprint Immature squamous metaplasia (focal atypical epithelial hyperplasia) of the pancreatic duct-immunohistochemical distinction from intraductal carcinoma
    Kunio Mochizuki
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Histopathology 63:343-50. 2013
    ..The aim of this study was to analyse 20 ISMPD and 10 ICP tissue samples...
  23. ncbi request reprint Mixed papillary adenocarcinoma and transitional cell carcinoma of the uterine cervix
    Shin Ichi Murata
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan
    Pathol Int 54:63-6. 2004
    ..These findings indicate that the TCC component had the cellular character of AC rather than that of TCC or squamous cell carcinomas. This is thought to be the first report of a MAcTcc of the uterine cervix...
  24. ncbi request reprint High prevalence of neuroendocrine carcinoma in breast lesions detected by the clinical symptom of bloody nipple discharge
    Tomonori Kawasaki
    Department of Pathology, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi 409 3898, Japan
    Breast 21:652-6. 2012
    ..However, the association between this symptom and breast neuroendocrine carcinomas (NECs) has not been sufficiently investigated or well understood...
  25. doi request reprint Transcription factor Runx2 is a regulator of epithelial-mesenchymal transition and invasion in thyroid carcinomas
    Dong Feng Niu
    Department of Pathology, University of Yamanashi, Yamanashi, Japan
    Lab Invest 92:1181-90. 2012
    ..Our data suggest that enhanced Runx2 is functionally linked to tumor invasion and metastasis of thyroid carcinoma by regulating EMT-related molecules, matrix metalloproteinases and angiogenic/lymphangiogenic factors...
  26. ncbi request reprint Laminar high shear stress up-regulates type IV collagen synthesis and down-regulates MMP-2 secretion in endothelium. A quantitative analysis
    Tetsu Yamane
    Department of Human Pathology, School of Medicine, University of Yamanashi, Yamanashi, Japan
    Cell Tissue Res 340:471-9. 2010
    ....
  27. ncbi request reprint Application of microscopic Forster resonance energy transfer to cytological diagnosis of the thyroid tumors
    Shin Ichi Murata
    University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Department of Pathology, Yamanashi, Japan
    J Biomed Opt 10:034008. 2005
    ..c) 2005 Society of Photo-Optical Instrumentation Engineers...
  28. doi request reprint Neuroendocrine cells associated with neuroendocrine carcinoma of the breast: nature and significance
    Tomonori Kawasaki
    Department of Pathology, University of Yamanashi, Yamanashi, Japan
    J Clin Pathol 65:699-703. 2012
    ..The developmental mechanisms of breast neuroendocrine carcinoma (B-NEC) have not been sufficiently analysed and are not well understood...
  29. ncbi request reprint Absence of human papillomavirus infection in minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia
    Jia Ying Xu
    Department of Obstetrics and Gynecology, University of Yamanashi, Yamanashi 409 3898, Japan
    Int J Gynecol Pathol 24:296-302. 2005
    ..However, no HPV DNA was detected in any of the 10 cases of LEGH or in the 3 cases of MDA. These results suggest that MDA and LEGH are probably not related to HPV infection...
  30. ncbi request reprint RET gene rearrangements (RET/PTC1 and RET/PTC3) in papillary thyroid carcinomas from an iodine-rich country (Japan)
    Tadao Nakazawa
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Cancer 104:943-51. 2005
    ..The authors investigated the prevalence of RET/PTC in a large number of thyroid tumors from Japanese patients...
  31. doi request reprint Clinical impact of preoperative screening for gastric mucin secretion in cervical discharge by HIK1083-labeled latex agglutination test
    Makiko Omori
    Obstetrics and Gynecology, National University Corporation University of Yamanashi, Yamanashi, Japan
    Am J Clin Pathol 130:585-94. 2008
    ..In 2 cases of LEGH, adenocarcinoma in situ was identified. Screening of gastric mucin in cervical discharge may facilitate preoperative detection of some early cervical adenocarcinoma...
  32. ncbi request reprint Epigenetic dysregulation in thyroid neoplasia
    Tetsuo Kondo
    Department of Pathology, University of Yamanashi, Japan
    Endocrinol Metab Clin North Am 37:389-400, ix. 2008
    ..The authors also discuss future applications of epigenetics as ancillary diagnostic tools and in the design of targeted therapies for thyroid cancer...
  33. ncbi request reprint Histopathology of the thyroid in amiodarone-induced hypothyroidism
    Tadao Nakazawa
    Department of Human Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi, Japan
    Pathol Int 58:55-8. 2008
    ..This is the first report on the histopathological findings of thyroid tissue from a patient with amiodarone-induced hypothyroidism...
  34. ncbi request reprint Differential tissue expression of enhanced green fluorescent protein in 'green mice'
    De Fu Ma
    Department of Human Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
    Histol Histopathol 25:749-54. 2010
    ..In conclusion, our results show that EGFP is differentially expressed in organs and tissues of 'green mice', which indicates that 'green mice' may prove useful for research involving transplantation and tissue clonality...
  35. doi request reprint Fine-needle aspiration biopsy of low-grade cribriform cystadenocarcinoma of the salivary gland
    Tadao Nakazawa
    Department of Pathology, University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, 1110 Shimokato, Yamanashi, Japan
    Diagn Cytopathol 39:218-22. 2011
    ..This is the first report of the cytomorphological findings of LGCCC...
  36. doi request reprint Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: Case report and literature review
    Naoki Oishi
    Department of Pathology, School of Medicine, University of Yamanashi, Japan
    Pathol Res Pract . 2014
    ..The patient had neither local recurrence nor distant metastasis 19 months after removal of the tumor...
  37. ncbi request reprint Localized Langerhans cell histiocytosis of the thymus with BRAF V600E mutation: a case report with immunohistochemical and genetic analyses
    Naoki Oishi
    Department of Pathology, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
    Hum Pathol 45:1302-5. 2014
    ..At the medical follow-up, the thymic tumor had spontaneously regressed; however, identification of oncogenic BRAF mutation supports the neoplastic nature of the current case. ..
  38. ncbi request reprint Detection of underlying characteristics of nuclear chromatin patterns of thyroid tumor cells using texture and factor analyses
    Shin Ichi Murata
    Department of Pathology, University of Yamanashi School of Medicine, Yamanashi, Japan
    Cytometry 49:91-5. 2002
    ..In the present report, we investigated how to detect underlying chromatin characteristics of benign and malignant thyroid tumor cells by means of texture and factor analyses...
  39. ncbi request reprint Expression of human pendrin in diseased thyroids
    Tetsuo Kondo
    Department of Pathology, Yamanashi Medical University School of Medicine, Japan
    J Histochem Cytochem 51:167-73. 2003
    ....
  40. doi request reprint Involvement of dynamin-2 in formation of discoid vesicles in urinary bladder umbrella cells
    Nobuo Terada
    Department of Anatomy and Molecular Histology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi, 409 3898, Japan
    Cell Tissue Res 337:91-102. 2009
    ..Pretreatment of bladders with dynasore inhibits E. coli invasion of UCs. Dyn2 thus contributes to the structural integrity of DVs and to the endocytic activity of UCs...
  41. ncbi request reprint [Hormone production and secretion in thyroid tumors]
    Ryohei Katoh
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
    Nihon Rinsho 62:929-33. 2004
    ..In recent years, evidence has been accumulating for the existence of a tumor group with traits of both follicular and medullary carcinoma, designated as mixed follicular and medullary carcinoma...
  42. ncbi request reprint Spatial distribution analysis of AT- and GC-rich regions in nuclei using corrected fluorescence resonance energy transfer
    Shin Ichi Murata
    Department of Pathology, University of Yamanashi School of Medicine, 1110 Shimokato, Tamaho cho Nakakoma gun, Yamanishi, Japan 409 3898
    J Histochem Cytochem 51:951-8. 2003
    ..Using the corrected FRET (cFRET) technique, we were able to detect early DNA separation stages in late interphase nuclei...
  43. ncbi request reprint Pathogenetic mechanisms in thyroid follicular-cell neoplasia
    Tetsuo Kondo
    Department of Pathology, University Health Network and Toronto Medical Laboratories, Department of Laboratory Medicine and Pathology, University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    Nat Rev Cancer 6:292-306. 2006
    ..This information can provide powerful ancillary diagnostic tools and can also be used to identify new therapeutic targets...
  44. ncbi request reprint The cancer/testis antigen melanoma-associated antigen-A3/A6 is a novel target of fibroblast growth factor receptor 2-IIIb through histone H3 modifications in thyroid cancer
    Tetsuo Kondo
    Department of Pathology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 13:4713-20. 2007
    ..In this analysis, we examined a novel target of FGFR2-IIIb signaling, melanoma-associated antigen-A3 and A6 (MAGE-A3/6)...
  45. ncbi request reprint Epigenetically controlled fibroblast growth factor receptor 2 signaling imposes on the RAS/BRAF/mitogen-activated protein kinase pathway to modulate thyroid cancer progression
    Tetsuo Kondo
    Department of Pathology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Cancer Res 67:5461-70. 2007
    ..These data unmask an epigenetically controlled FGFR2 signal that imposes precisely on the intragenically modified BRAF/MAPK pathway to modulate thyroid cancer behavior...