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Genomes and Genes | Tetsuo KondoSummaryAffiliation: University of Yamanashi Country: Japan Publications
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Publications
Unusual thyroid carcinoma with excessive extracellular hyaline globules: a case of "hyalinizing papillary carcinoma"Tetsuo Kondo
Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, 409 3898, Japan
Hum Pathol 43:932-8. 2012..Based on these findings, we diagnosed the present tumor as a rare morphological variation of papillary thyroid carcinoma with excessive hyaline globules consisting of basal membrane materials...
Mucinous carcinoma (poorly differentiated carcinoma with extensive extracellular mucin deposition) of the thyroid: a case report with immunohistochemical studiesTetsuo Kondo
Department of Pathology, University of Yamanashi, Yamanashi, Japan
Hum Pathol 36:698-701. 2005..The patient died of multiple metastases 4 years after the initial operation...- Enhanced B-Raf protein expression is independent of V600E mutant status in thyroid carcinomasTetsuo Kondo
Department of Pathology, University of Yamanashi, Chuo, Yamanashi 409 3898, Japan
Hum Pathol 38:1810-8. 2007.... - Gastric mucin is expressed in a subset of endocervical tunnel clusters: type A tunnel clusters of gastric phenotypeT Kondo
Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
Histopathology 50:843-50. 2007..Gastric mucin expression has been demonstrated in a group of endocervical glandular lesions. The aim of this study was to gain further insight into endocervical lesions with a gastric phenotype... - Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomasTetsuo Kondo
Department of Pathology, University of Yamanashi, Yamanashi, Japan
Lab Invest 89:791-9. 2009..Our data suggest that epigenetics is involved with inactivation of TTF-1 in thyroid carcinomas, and provide a possible means of using TTF-1 as a target for differentiation-inducing therapy through epigenetic modification... - Endocervical adenocarcinomas associated with lobular endocervical glandular hyperplasia: a report of four cases with histochemical and immunohistochemical analysesTetsuo Kondo
Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
Mod Pathol 18:1199-210. 2005..Histopathological features of the present cases suggest that some endocervical adenocarcinomas may originate from lobular endocervical glandular hyperplasia... - Stromal elastosis in papillary thyroid carcinomasTetsuo Kondo
Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan
Hum Pathol 36:474-9. 2005..It is, therefore, reasonable to propose that stromal elastosis is an ancillary feature in the histopathological diagnosis of PTCs... - Lobular endocervical glandular hyperplasia as a presumed precursor of cervical adenocarcinoma independent of human papillomavirus infectionMasatoshi Nara
Department of Obstetrics and Gynecology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
Gynecol Oncol 106:289-98. 2007..The aim of this study was to investigate differences in the process of carcinogenesis between adenocarcinoma coexistent with LEGH and conventional adenocarcinoma. And we intend to describe appropriate treatment plans for LEGH in this study... - Conservation and alteration of chromosome territory arrangements in thyroid carcinoma cell nucleiShin Ichi Murata
Department of Pathology, Saitama Medical University International Medical Center, Saitama, Japan
Thyroid 17:489-96. 2007..These findings indicate that alteration of CT positioning could be related to DNA amplification and, morphologically, may explain the nuclear atypia that accompanies the abnormal chromatin feature... - Polyclonal origin of hormone-producing cell populations evaluated as a direct in situ demonstration in EGFP/BALB/C chimeric miceDe Fu Ma
Department of Pathology, University of Yamanashi, Chuo Yamanashi, Japan
J Endocrinol 207:17-25. 2010..Furthermore, we clearly demonstrate that all hormone-producing cell populations are of polyclonal embryonic origin, derived from more than two progenitor cells... - Morphological abstraction of thyroid tumor cell nuclei using morphometry with factor analysisShin Ichi Murata
Department of Pathology, University of Yamanashi School of Medicine, Nakakoma gun, Yamanashi, Japan
Microsc Res Tech 61:457-62. 2003..Morphological abstraction by morphometry with factor analysis may provide a practical approach to the detection of the underlying characteristics of nuclear morphology in aspiration biopsy cytology... - p16INK4a overexpression independent of human papillomavirus infection in lobular endocervical glandular hyperplasiaAkihiko Hashi
Department of Obstetrics and Gynecology, and Clinical Laboratory, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
Int J Gynecol Pathol 25:187-94. 2006..Overall, p16INK4a overexpression was seen in 87.5% of the cases (21/24). HPV DNA was not detected in any of the 24 LEGH cases. These results suggest that p16INK4a overexpression is independent of HPV infection in LEGH... 
Differential expression of aquaporins and its diagnostic utility in thyroid cancerDongfeng Niu
Department of Human Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi, Japan
PLoS ONE 7:e40770. 2012..Little is known of their expression and significance in human thyroid tissues. Thus, we examined the expression of AQP3 and AQP4 in normal, hyperplastic and neoplastic thyroid tissues in conjunction with human thyroid cancer cell lines...- Expression of aquaporin 3 (AQP3) in normal and neoplastic lung tissuesYa Lan Liu
Department of Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi 409 3898, Japan
Hum Pathol 38:171-8. 2007.... - Global histone modification of histone H3 in colorectal cancer and its precursor lesionsTadao Nakazawa
Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409 3898, Japan
Hum Pathol 43:834-42. 2012..These results suggest that aberration of the global H3K9me2 level is an important epigenetic event in colorectal tumorigenesis and carcinogenesis involved with gene regulation in neoplastic cells through chromatin remodeling... - RET/PTC rearrangements arising from a small population of papillary thyroid carcinoma cells, possible candidate for passenger mutationTadao Nakazawa
Department of Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, 1110 Shimokato, Chuo, Yamanashi, 409 3898, Japan
Virchows Arch 455:35-41. 2009.... - Involvement of centrosomes in nuclear irregularity of thyroid carcinoma cellsDongfeng Niu
Department of Human Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409 3898, Japan
Virchows Arch 455:149-57. 2009..In conclusion, we suggest that cell-to-cell contact may affect nuclear changes such as BLNs and DLNs in cancer cell lines and that centrosomes may be involved in the morphogenetic process of these nuclear changes... - RET rearrangements and BRAF mutation in undifferentiated thyroid carcinomas having papillary carcinoma componentsKunio Mochizuki
Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan
Histopathology 57:444-50. 2010..To elucidate the genetic background of anaplastic transformation, RET rearrangements and BRAF mutation were studied in composite undifferentiated carcinomas (UCs) of the thyroid, which are UCs having papillary carcinoma (PC) components... - Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cellsDe Fu Ma
Department of Pathology, University of Yamanashi, Yamanashi, 409 3898, Japan
Hum Pathol 41:1550-7. 2010..Our data suggest that this adenosine receptor is a potential therapeutic target for colorectal cancer... - p16(INK4a) expression analysis as an ancillary tool for cytologic diagnosis of urothelial carcinomaKumiko Nakazawa
Department of Pathology, University of Hospital, Faculty of Medicine, University of Yamanashi, Yamanashi 409 3898, Japan
Am J Clin Pathol 132:776-84. 2009..Immunocytologic analysis of p16(INK4a) expression in cytologic samples is a useful ancillary tool for detection of urothelial carcinoma with infiltrating potential... - Intranuclear cytoplasmic inclusion is a significant diagnostic feature for the differentiation of lobular endocervical glandular hyperplasia from minimal deviation adenocarcinoma of the cervixAkihiko Hashi
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Yamanashi, Japan
Diagn Cytopathol 36:535-44. 2008..The presence of an INCI is a good parameter for the diagnosis of LEGH. Cytology is an effective aid in the differentiation of LEGH from MDA... - Mixed papillary adenocarcinoma and transitional cell carcinoma of the uterine cervixShin Ichi Murata
Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan
Pathol Int 54:63-6. 2004..These findings indicate that the TCC component had the cellular character of AC rather than that of TCC or squamous cell carcinomas. This is thought to be the first report of a MAcTcc of the uterine cervix... - High prevalence of neuroendocrine carcinoma in breast lesions detected by the clinical symptom of bloody nipple dischargeTomonori Kawasaki
Department of Pathology, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi 409 3898, Japan
Breast 21:652-6. 2012..However, the association between this symptom and breast neuroendocrine carcinomas (NECs) has not been sufficiently investigated or well understood... - Transcription factor Runx2 is a regulator of epithelial-mesenchymal transition and invasion in thyroid carcinomasDong Feng Niu
Department of Pathology, University of Yamanashi, Yamanashi, Japan
Lab Invest 92:1181-90. 2012..Our data suggest that enhanced Runx2 is functionally linked to tumor invasion and metastasis of thyroid carcinoma by regulating EMT-related molecules, matrix metalloproteinases and angiogenic/lymphangiogenic factors... - Application of microscopic Forster resonance energy transfer to cytological diagnosis of the thyroid tumorsShin Ichi Murata
University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Department of Pathology, Yamanashi, Japan
J Biomed Opt 10:034008. 2005..c) 2005 Society of Photo-Optical Instrumentation Engineers... - Laminar high shear stress up-regulates type IV collagen synthesis and down-regulates MMP-2 secretion in endothelium. A quantitative analysisTetsu Yamane
Department of Human Pathology, School of Medicine, University of Yamanashi, Yamanashi, Japan
Cell Tissue Res 340:471-9. 2010.... - Neuroendocrine cells associated with neuroendocrine carcinoma of the breast: nature and significanceTomonori Kawasaki
Department of Pathology, University of Yamanashi, Yamanashi, Japan
J Clin Pathol 65:699-703. 2012..The developmental mechanisms of breast neuroendocrine carcinoma (B-NEC) have not been sufficiently analysed and are not well understood... - Clinical impact of preoperative screening for gastric mucin secretion in cervical discharge by HIK1083-labeled latex agglutination testMakiko Omori
Obstetrics and Gynecology, National University Corporation University of Yamanashi, Yamanashi, Japan
Am J Clin Pathol 130:585-94. 2008..In 2 cases of LEGH, adenocarcinoma in situ was identified. Screening of gastric mucin in cervical discharge may facilitate preoperative detection of some early cervical adenocarcinoma... - Epigenetic dysregulation in thyroid neoplasiaTetsuo Kondo
Department of Pathology, University of Yamanashi, Japan
Endocrinol Metab Clin North Am 37:389-400, ix. 2008..The authors also discuss future applications of epigenetics as ancillary diagnostic tools and in the design of targeted therapies for thyroid cancer... - RET gene rearrangements (RET/PTC1 and RET/PTC3) in papillary thyroid carcinomas from an iodine-rich country (Japan)Tadao Nakazawa
Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
Cancer 104:943-51. 2005..Therefore, the current results raise questions regarding the belief that the frequency of RET/PTC differs geographically and is especially low in Japan... - Absence of human papillomavirus infection in minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasiaJia-Ying Xu
Department of Obstetrics and Gynecology, University of Yamanashi, Yamanashi 409-3898, Japan
Int J Gynecol Pathol 24:296-302. 2005..However, no HPV DNA was detected in any of the 10 cases of LEGH or in the 3 cases of MDA. These results suggest that MDA and LEGH are probably not related to HPV infection... - Histopathology of the thyroid in amiodarone-induced hypothyroidismTadao Nakazawa
Department of Human Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi, Japan
Pathol Int 58:55-8. 2008..This is the first report on the histopathological findings of thyroid tissue from a patient with amiodarone-induced hypothyroidism... - Detection of underlying characteristics of nuclear chromatin patterns of thyroid tumor cells using texture and factor analysesShin Ichi Murata
Department of Pathology, University of Yamanashi School of Medicine, Yamanashi, Japan
Cytometry 49:91-5. 2002..In the present report, we investigated how to detect underlying chromatin characteristics of benign and malignant thyroid tumor cells by means of texture and factor analyses... - Fine-needle aspiration biopsy of low-grade cribriform cystadenocarcinoma of the salivary glandTadao Nakazawa
Department of Pathology, University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, 1110 Shimokato, Yamanashi, Japan
Diagn Cytopathol 39:218-22. 2011..This is the first report of the cytomorphological findings of LGCCC... - Differential tissue expression of enhanced green fluorescent protein in 'green mice'De Fu Ma
Department of Human Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
Histol Histopathol 25:749-54. 2010..In conclusion, our results show that EGFP is differentially expressed in organs and tissues of 'green mice', which indicates that 'green mice' may prove useful for research involving transplantation and tissue clonality... - Expression of human pendrin in diseased thyroidsTetsuo Kondo
Department of Pathology, Yamanashi Medical University School of Medicine, Japan
J Histochem Cytochem 51:167-73. 2003.... - Involvement of dynamin-2 in formation of discoid vesicles in urinary bladder umbrella cellsNobuo Terada
Department of Anatomy and Molecular Histology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo City, Yamanashi, 409 3898, Japan
Cell Tissue Res 337:91-102. 2009..Pretreatment of bladders with dynasore inhibits E. coli invasion of UCs. Dyn2 thus contributes to the structural integrity of DVs and to the endocytic activity of UCs... - [Hormone production and secretion in thyroid tumors]Ryohei Katoh
Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
Nippon Rinsho 62:929-33. 2004..In recent years, evidence has been accumulating for the existence of a tumor group with traits of both follicular and medullary carcinoma, designated as mixed follicular and medullary carcinoma... - Spatial distribution analysis of AT- and GC-rich regions in nuclei using corrected fluorescence resonance energy transferShin Ichi Murata
Department of Pathology, University of Yamanashi School of Medicine, 1110 Shimokato, Tamaho cho Nakakoma gun, Yamanishi, Japan 409 3898
J Histochem Cytochem 51:951-8. 2003..Using the corrected FRET (cFRET) technique, we were able to detect early DNA separation stages in late interphase nuclei... - Pathogenetic mechanisms in thyroid follicular-cell neoplasiaTetsuo Kondo
Department of Pathology, University Health Network and Toronto Medical Laboratories, Department of Laboratory Medicine and Pathology, University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
Nat Rev Cancer 6:292-306. 2006..This information can provide powerful ancillary diagnostic tools and can also be used to identify new therapeutic targets... - Epigenetically controlled fibroblast growth factor receptor 2 signaling imposes on the RAS/BRAF/mitogen-activated protein kinase pathway to modulate thyroid cancer progressionTetsuo Kondo
Department of Pathology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
Cancer Res 67:5461-70. 2007..These data unmask an epigenetically controlled FGFR2 signal that imposes precisely on the intragenically modified BRAF/MAPK pathway to modulate thyroid cancer behavior... - The cancer/testis antigen melanoma-associated antigen-A3/A6 is a novel target of fibroblast growth factor receptor 2-IIIb through histone H3 modifications in thyroid cancerTetsuo Kondo
Department of Pathology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
Clin Cancer Res 13:4713-20. 2007..In this analysis, we examined a novel target of FGFR2-IIIb signaling, melanoma-associated antigen-A3 and A6 (MAGE-A3/6)...