Shinsuke Koike

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint Multi-modal brain imaging showing brain damage to the orbitofrontal cortex and left hemisphere, in a case of prolonged hypoglycemia-induced transient hemiplegia followed by persistent encephalopathy
    Shinsuke Koike
    Department of Psychiatry, Tokyo Metropolitan Bokuto Hospital, Tokyo, Japan
    Psychiatry Clin Neurosci 67:360-2. 2013
  2. doi request reprint Reduced but broader prefrontal activity in patients with schizophrenia during n-back working memory tasks: a multi-channel near-infrared spectroscopy study
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Psychiatr Res 47:1240-6. 2013
  3. doi request reprint A multimodal approach to investigate biomarkers for psychosis in a clinical setting: the integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 143:116-24. 2013
  4. doi request reprint Association between severe dorsolateral prefrontal dysfunction during random number generation and earlier onset in schizophrenia
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Neurophysiol 122:1533-40. 2011
  5. pmc Comprehensive early intervention for patients with first-episode psychosis in Japan (J-CAP): study protocol for a randomised controlled trial
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, 113 8655, Japan
    Trials 12:156. 2011
  6. doi request reprint Different hemodynamic response patterns in the prefrontal cortical sub-regions according to the clinical stages of psychosis
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 132:54-61. 2011
  7. doi request reprint Localized gray matter volume reductions in the pars triangularis of the inferior frontal gyrus in individuals at clinical high-risk for psychosis and first episode for schizophrenia
    Norichika Iwashiro
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 137:124-31. 2012
  8. doi request reprint Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals
    Yukika Nishimura
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan Department of Youth Mental Health, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Neuroimage 85:527-34. 2014
  9. doi request reprint Potential biomarker of subjective quality of life: prefrontal activation measurement by near-infrared spectroscopy
    Yoshihiro Satomura
    a Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo Study Site, Bunkyo ku, Tokyo, Japan
    Soc Neurosci 9:63-73. 2014
  10. doi request reprint Distinct effects of duration of untreated psychosis on brain cortical activities in different treatment phases of schizophrenia: a multi-channel near-infrared spectroscopy study
    Po Han Chou
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, 113 8655, Japan Department of Psychiatry, Taichung Veterans General Hospital, Taichung City, 40705, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 49:63-9. 2014

Collaborators

Detail Information

Publications14

  1. doi request reprint Multi-modal brain imaging showing brain damage to the orbitofrontal cortex and left hemisphere, in a case of prolonged hypoglycemia-induced transient hemiplegia followed by persistent encephalopathy
    Shinsuke Koike
    Department of Psychiatry, Tokyo Metropolitan Bokuto Hospital, Tokyo, Japan
    Psychiatry Clin Neurosci 67:360-2. 2013
    ..Transient hemiplegia corresponded to abnormal waveforms on EEG and decreased cerebral blood flow on SPECT, whereas persistent dysfunctions corresponded to abnormal brain regions on MRI and SPECT. ..
  2. doi request reprint Reduced but broader prefrontal activity in patients with schizophrenia during n-back working memory tasks: a multi-channel near-infrared spectroscopy study
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Psychiatr Res 47:1240-6. 2013
    ....
  3. doi request reprint A multimodal approach to investigate biomarkers for psychosis in a clinical setting: the integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 143:116-24. 2013
    ..0%, and 35.3% (at 6, 12, and 24months, respectively). Through this research project, we expect to clarify the pathophysiological features around the onset of psychosis and improve the prognosis of psychosis through clinical application...
  4. doi request reprint Association between severe dorsolateral prefrontal dysfunction during random number generation and earlier onset in schizophrenia
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Neurophysiol 122:1533-40. 2011
    ..Age at onset is a major factor for predicting social outcome in schizophrenia. In clinical settings, we need an objective assessment tool for evaluating prefrontal function and social outcome...
  5. pmc Comprehensive early intervention for patients with first-episode psychosis in Japan (J-CAP): study protocol for a randomised controlled trial
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, 113 8655, Japan
    Trials 12:156. 2011
    ..The purpose of this trial is to investigate the effectiveness and affordability of 18-month comprehensive early intervention services for patients with first-episode psychosis compared with typical treatment...
  6. doi request reprint Different hemodynamic response patterns in the prefrontal cortical sub-regions according to the clinical stages of psychosis
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 132:54-61. 2011
    ..Multichannel near-infrared spectroscopy (NIRS), which can easily and noninvasively measure hemodynamics over the prefrontal cortex, is a candidate instrument for clinical use...
  7. doi request reprint Localized gray matter volume reductions in the pars triangularis of the inferior frontal gyrus in individuals at clinical high-risk for psychosis and first episode for schizophrenia
    Norichika Iwashiro
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 137:124-31. 2012
    ..The right PT might preferentially contribute to the pathogenesis of psychotic symptoms...
  8. doi request reprint Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals
    Yukika Nishimura
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan Department of Youth Mental Health, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Neuroimage 85:527-34. 2014
    ..Genetic variation in EGR3 may affect prefrontal function through neurodevelopment. This study illustrates the usefulness of NIRS in imaging genetics investigations on psychiatric disorders. ..
  9. doi request reprint Potential biomarker of subjective quality of life: prefrontal activation measurement by near-infrared spectroscopy
    Yoshihiro Satomura
    a Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo Study Site, Bunkyo ku, Tokyo, Japan
    Soc Neurosci 9:63-73. 2014
    ..These findings suggest that subjective QOL has possible involvement in prefrontal function and that NIRS potentially plays a role as a biological marker of subjective QOL...
  10. doi request reprint Distinct effects of duration of untreated psychosis on brain cortical activities in different treatment phases of schizophrenia: a multi-channel near-infrared spectroscopy study
    Po Han Chou
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, 113 8655, Japan Department of Psychiatry, Taichung Veterans General Hospital, Taichung City, 40705, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 49:63-9. 2014
    ..In the present study, we used near-infrared spectroscopy (NIRS) to investigate the influence of DUP on brain functions during a verbal fluency test (VFT) in patients with schizophrenia...
  11. doi request reprint Genetic influences on prefrontal activation during a verbal fluency task in adults: a twin study based on multichannel near-infrared spectroscopy
    Eisuke Sakakibara
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan 2 Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan Electronic address
    Neuroimage 85:508-17. 2014
    ..This implies that the prefrontal hemodynamic dysfunction observed during an executive function task measured by NIRS may be an efficient endophenotype for large-scale imaging genetic studies in psychiatric disorders. ..
  12. pmc Altered metabolites in the plasma of autism spectrum disorder: a capillary electrophoresis time-of-flight mass spectroscopy study
    Hitoshi Kuwabara
    Department of Child Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 8:e73814. 2013
    ..001) and low lactic acid (pā€Š=ā€Š0.003) in the combined sample (nā€Š=ā€Š53). The present study identified deviated plasma metabolite levels associated with oxidative stress and mitochondrial dysfunction in individuals with ASD. ..
  13. doi request reprint Comprehensive DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia
    Masaki Nishioka
    Department of Molecular Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Hum Genet 58:91-7. 2013
    ..Our results indicate the site-specific epigenetic alterations in patients with FESZ...
  14. ncbi request reprint [Biological study in schizophrenia]
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Brain Nerve 64:109-18. 2012
    ..Additionally, we present the preliminary findings of the clinical research in our outpatient unit, specialized for early intervention, at the University of Tokyo Hospital...