Kazuhiko Koike

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Molecular mechanism of viral hepatocarcinogenesis
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Oncology 62:29-37. 2002
  2. ncbi request reprint Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance
    Yoshizumi Shintani
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Gastroenterology 126:840-8. 2004
  3. doi request reprint The oncogenic role of hepatitis C virus
    Kazuhiko Koike
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Recent Results Cancer Res 193:97-111. 2014
  4. pmc Validation of the Japanese version of the EORTC hepatocellular carcinoma-specific quality of life questionnaire module (QLQ-HCC18)
    Naoko Mikoshiba
    Department of Adult Nursing, Division of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Health Qual Life Outcomes 10:58. 2012
  5. pmc Lifestyle factors affecting gastroesophageal reflux disease symptoms: a cross-sectional study of healthy 19864 adults using FSSG scores
    Nobutake Yamamichi
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, Japan
    BMC Med 10:45. 2012
  6. pmc Postprandial fullness correlates with rapid inflow of gastric content into duodenum but not with chronic gastritis
    Nobutake Yamamichi
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo 7 3 1, Hongo, Bunkyo ku, Tokyo, Japan
    BMC Gastroenterol 11:140. 2011
  7. pmc LXR agonist increases apoE secretion from HepG2 spheroid, together with an increased production of VLDL and apoE-rich large HDL
    Makoto Kurano
    Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Lipids Health Dis 10:134. 2011
  8. pmc Acquisition of methicillin-resistant Staphylococcus aureus after living donor liver transplantation: a retrospective cohort study
    Masao Hashimoto
    Artificial Organ and Transplantation Division, Department of Surgery, University of Tokyo, Tokyo, Japan
    BMC Infect Dis 8:155. 2008
  9. doi request reprint Molecular basis for the synergy between alcohol and hepatitis C virus in hepatocarcinogenesis
    Kazuhiko Koike
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 23:S87-91. 2008
  10. ncbi request reprint Antiviral treatment of hepatitis C: present status and future prospects
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Infect Chemother 12:227-32. 2006

Detail Information

Publications199 found, 100 shown here

  1. ncbi request reprint Molecular mechanism of viral hepatocarcinogenesis
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Oncology 62:29-37. 2002
    ..Such a scenario would explain an unusually high incidence and multicentric nature of HCC developing in chronic hepatitis B or C...
  2. ncbi request reprint Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance
    Yoshizumi Shintani
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Gastroenterology 126:840-8. 2004
    ..However, the presence of additional factors such as obesity, aging, or cirrhosis prevents the establishment of a definite relationship between these 2 conditions...
  3. doi request reprint The oncogenic role of hepatitis C virus
    Kazuhiko Koike
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Recent Results Cancer Res 193:97-111. 2014
    ..These results would provide a clue for further understanding of the role of HCV in pathogenesis of persistent HCV infection including hepatocarcinogenesis...
  4. pmc Validation of the Japanese version of the EORTC hepatocellular carcinoma-specific quality of life questionnaire module (QLQ-HCC18)
    Naoko Mikoshiba
    Department of Adult Nursing, Division of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Health Qual Life Outcomes 10:58. 2012
    ..This Study Examined The Measurement Properties Of The Japanese Version Of The European Organisation for Research and Treatment of Cancer (EORTC) Hepatocellular Carcinoma-Specific Quality of Life Questionnaire (QLQ-HCC18)...
  5. pmc Lifestyle factors affecting gastroesophageal reflux disease symptoms: a cross-sectional study of healthy 19864 adults using FSSG scores
    Nobutake Yamamichi
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, Japan
    BMC Med 10:45. 2012
    ..Nevertheless, compared with many reports targeting endoscopic reflux esophagitis, large-scale studies focusing on GERD symptoms have been very scarce...
  6. pmc Postprandial fullness correlates with rapid inflow of gastric content into duodenum but not with chronic gastritis
    Nobutake Yamamichi
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo 7 3 1, Hongo, Bunkyo ku, Tokyo, Japan
    BMC Gastroenterol 11:140. 2011
    ..The aim of this study is evaluating the correlation of postprandial fullness with chronic gastritis or rapid inflow of gastric content into duodenum, based on double-contrast barium X-ray imaging...
  7. pmc LXR agonist increases apoE secretion from HepG2 spheroid, together with an increased production of VLDL and apoE-rich large HDL
    Makoto Kurano
    Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Lipids Health Dis 10:134. 2011
    ..The physiological regulation of hepatic apoE gene has not been clarified, although the expression of apoE in adipocytes and macrophages has been known to be regulated by LXR...
  8. pmc Acquisition of methicillin-resistant Staphylococcus aureus after living donor liver transplantation: a retrospective cohort study
    Masao Hashimoto
    Artificial Organ and Transplantation Division, Department of Surgery, University of Tokyo, Tokyo, Japan
    BMC Infect Dis 8:155. 2008
    ..The aim of the present study was to assess the incidence and to analyze the risk factors for the acquisition of MRSA after LDLT in adults by multivariate analysis...
  9. doi request reprint Molecular basis for the synergy between alcohol and hepatitis C virus in hepatocarcinogenesis
    Kazuhiko Koike
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 23:S87-91. 2008
    ..Such a synergy would reveal the molecular basis for the acceleration of HCC development by alcohol in HCV infection...
  10. ncbi request reprint Antiviral treatment of hepatitis C: present status and future prospects
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Infect Chemother 12:227-32. 2006
    ..Thus, the treatment for HCV infection has progressed significantly, but therapies with new modalities, such as inhibitors of viral protease or RNA polymerase, are still being awaited...
  11. ncbi request reprint Hepatitis C virus infection can present with metabolic disease by inducing insulin resistance
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Intervirology 49:51-7. 2006
    ..In conclusion, towards the future, HCV infection needs to be viewed not only as a liver disease but also as a metabolic disease...
  12. ncbi request reprint Molecular basis of hepatitis C virus-associated hepatocarcinogenesis: lessons from animal model studies
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Clin Gastroenterol Hepatol 3:S132-5. 2005
    ..Such a scenario, "non-Vogelstein type" carcinogenesis, may explain the unusually high incidence and multicentric nature of HCC development in HCV infection...
  13. ncbi request reprint Hepatitis C virus contributes to hepatocarcinogenesis by modulating metabolic and intracellular signaling pathways
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Gastroenterol Hepatol 22:S108-11. 2007
    ..Such a scenario, 'non-Vogelstein-type' carcinogenesis, would explain the rare feature of hepatocarcinogenesis in HCV infection, the extraordinarily high incidence and the multicentric nature of HCC development...
  14. ncbi request reprint Role of hepatitis C virus in the development of hepatocellular carcinoma: transgenic approach to viral hepatocarcinogenesis
    Kazuhiko Koike
    Department of Infectious Diseases, Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol Hepatol 17:394-400. 2002
    ....
  15. ncbi request reprint Compensatory apoptosis in preneoplastic liver of a transgenic mouse model for viral hepatocarcinogenesis
    K Koike
    First Department of Internal Medicine, University of Tokyo, Japan
    Cancer Lett 134:181-6. 1998
    ..The disappearance or block of apoptotic signals, which may be the result of additional genetic or epigenetic aberrations, may result in the preneoplastic hepatocytes becoming neoplastic...
  16. doi request reprint A retrospective study of S-1 and oxaliplatin combination chemotherapy in patients with refractory pancreatic cancer
    Naminatsu Takahara
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Cancer Chemother Pharmacol 72:985-90. 2013
    ..The aim of this study was to evaluate S-1 and oxaliplatin combination chemotherapy (SOX) in patients with refractory pancreatic cancer (PC)...
  17. doi request reprint Erlotinib prolongs survival in pancreatic cancer by blocking gemcitabine-induced MAPK signals
    Koji Miyabayashi
    Department of Gastroetnterology, Graduate School of Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Res 73:2221-34. 2013
    ..Overall, our findings suggest a significant role of ERBB in PDAC treatment...
  18. doi request reprint Clinical outcomes of chemotherapy for diabetic and nondiabetic patients with pancreatic cancer: better prognosis with statin use in diabetic patients
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Pancreas 42:202-8. 2013
    ....
  19. pmc Differential roles of ASK1 and TAK1 in Helicobacter pylori-induced cellular responses
    Yoku Hayakawa
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Infect Immun 81:4551-60. 2013
    ..The balance of ASK1-induced apoptosis and TAK1-induced antiapoptotic or inflammatory responses may determine the fate of epithelial cells infected with H. pylori and thus be involved in the pathogenesis of gastritis and gastric cancer. ..
  20. pmc Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis C virus core protein: analysis using mouse model and cultured cells
    Kyoji Moriya
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Am J Pathol 175:1515-24. 2009
    ..These results may provide new therapeutic tools for chronic hepatitis C, in which oxidative stress and abnormalities in lipid and glucose metabolism contribute to liver pathogenesis...
  21. doi request reprint Japanese multicenter estimation of WallFlex duodenal stent for unresectable malignant gastric outlet obstruction
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Dig Endosc 25:1-6. 2013
    ..This retrospective study estimated the efficacy and safety of the WallFlex duodenal stent for malignant gastric outlet obstruction (GOO) in Japan...
  22. doi request reprint Gastric cancer risk according to the distribution of intestinal metaplasia and neutrophil infiltration
    Kosuke Sakitani
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 26:1570-5. 2011
    ..We aimed to elucidate the association between gastric cancer risk and the distribution of precancerous lesions in the stomach by histological analyses...
  23. pmc Radiofrequency ablation for hepatocellular carcinoma: 10-year outcome and prognostic factors
    Shuichiro Shiina
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Am J Gastroenterol 107:569-77; quiz 578. 2012
    ..However, there has been no report on 10-year outcome of RFA. The objective of this study was to report a 10-year consecutive case series at a tertiary referral center...
  24. doi request reprint Prognostic factors in patients with advanced biliary tract cancer receiving chemotherapy
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cancer Chemother Pharmacol 67:847-53. 2011
    ..Gallbladder cancer and intra-hepatic cholangiocarcinoma are previously reported prognostic factors of poor prognosis; however, tumor volume has not been analyzed in these previous reports...
  25. ncbi request reprint Management of dysfunctional covered self-expandable metallic stents in patients with malignant distal biliary obstruction
    Osamu Togawa
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 48:1300-7. 2013
    ..Endoscopic placement of covered self-expandable metallic stents (CSEMSs) is effective for distal malignant biliary obstruction. However, management of dysfunctional CSEMSs has not been established...
  26. ncbi request reprint Factors predictive of inaccurate determination of horizontal extent of intestinal-type early gastric cancers during endoscopic submucosal dissection: a retrospective analysis
    Itsuko Asada-Hirayama
    Department of Gastroenterology, The University of Tokyo, Tokyo, Japan
    Dig Endosc 25:593-600. 2013
    ..In the present study, clinicopathological features related to inaccurate endoscopic evaluation of horizontal extent of intestinal-type EGC were analyzed...
  27. doi request reprint Preliminary report on a new, fully covered, metal stent designed for the treatment of pancreatic fluid collections
    Natsuyo Yamamoto
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Gastrointest Endosc 77:809-14. 2013
    ..Endoscopic transluminal treatment of pancreatic fluid collections (PFC) has been reported as an effective alternative approach to surgical treatment. A wide, short stent with an anti-migration system has been developed...
  28. doi request reprint Predictive factors of solid food intake in patients with malignant gastric outlet obstruction receiving self-expandable metallic stents for palliation
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo Department of Gastroenterology, Tokyo, Japan
    Dig Endosc 24:226-30. 2012
    ..Therefore, we analyzed the predictive factors of oral food intake following SEMS placement...
  29. doi request reprint Specific increase in serum autotaxin activity in patients with pancreatic cancer
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Biochem 44:576-81. 2011
    ..To evaluate the potential clinical significance of serum autotaxin (ATX) level in patients with cancers of the digestive system...
  30. ncbi request reprint A retrospective study of gemcitabine and cisplatin combination therapy as second-line treatment for advanced biliary tract cancer
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Chemotherapy 59:106-11. 2013
    ..To evaluate the treatment outcome of gemcitabine and cisplatin combination therapy as second-line treatment for advanced biliary tract cancer...
  31. doi request reprint Duodenal metal stent placement is a risk factor for biliary metal stent dysfunction: an analysis using a time-dependent covariate
    Tsuyoshi Hamada
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Endosc 27:1243-8. 2013
    ..We conducted a multicenter retrospective study to evaluate the effect of duodenal SEMS placement on biliary SEMS...
  32. doi request reprint Feasibility of a new self-expandable metallic stent for patients with malignant colorectal obstruction
    Shuntaro Yoshida
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan
    Dig Endosc 25:160-6. 2013
    ..An uncovered SEMS (Niti-S Enteral Colonic Uncovered Stent, D-type; Taewoong, Inc., Gimpo, South Korea) with improved conformability is considered to decrease migration...
  33. doi request reprint Management of malignant gastric outlet obstruction with a modified triple-layer covered metal stent
    Hiroyuki Isayama
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Gastrointest Endosc 75:757-63. 2012
    ..A newly modified, partially covered, triple-layer nitinol stent was developed that has a longer uncovered portion (5-15 mm) to prevent stent migration...
  34. pmc The effectiveness of liraglutide in nonalcoholic fatty liver disease patients with type 2 diabetes mellitus compared to sitagliptin and pioglitazone
    Takamasa Ohki
    Department of Gastroenterology, Mitsui Memorial Hospital, Kanda Izumicho 1, Chiyoda ku, Tokyo, Japan
    ScientificWorldJournal 2012:496453. 2012
    ..04; 95% CI 1.12-73.1, P = 0.04). CONCLUSIONS. Administration of liraglutide improved T2DM but also improvement of liver inflammation, alteration of liver fibrosis, and reduction of body weight...
  35. doi request reprint Systemic combination therapy of intravenous continuous 5-fluorouracil and subcutaneous pegylated interferon alfa-2a for advanced hepatocellular carcinoma
    Koji Uchino
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:1152-9. 2012
    ....
  36. doi request reprint Multicenter phase II study of S-1 monotherapy as second-line chemotherapy for advanced biliary tract cancer refractory to gemcitabine
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Invest New Drugs 30:708-13. 2012
    ..The most common non-hematological toxicities were nausea (27%), anorexia (55%), and pigmentation (32%). In conclusion, S-1 monotherapy is feasible and moderately efficacious second-line chemotherapy for advanced BTC...
  37. doi request reprint Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway
    Yotaro Kudo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatol 55:1400-8. 2011
    ....
  38. doi request reprint Duodenal invasion is a risk factor for the early dysfunction of biliary metal stents in unresectable pancreatic cancer
    Tsuyoshi Hamada
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Gastrointest Endosc 74:548-55. 2011
    ..Although the placement of self-expandable metal stents (SEMSs) has been widely accepted as palliation for distal malignant biliary obstruction, the risk factors for their early dysfunction remain unclear...
  39. doi request reprint Efficacy and safety of covered self-expandable metal stents for management of distal malignant biliary obstruction due to lymph node metastases
    Kazumichi Kawakubo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Surg Endosc 25:3094-100. 2011
    ..However, the role of covered self-expandable metal stents (SEMS) in treating MBO has not been studied. The aim of this study was to evaluate the efficacy and safety of covered SEMS for the treatment of distal MBO due to LNM...
  40. doi request reprint Hepatocellular carcinoma with extrahepatic metastasis: clinical features and prognostic factors
    Koji Uchino
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer 117:4475-83. 2011
    ..The objective of this study was to further elucidate the clinical course and prognostic determinants of patients with this disease...
  41. pmc Regulation of the expression of the liver cancer susceptibility gene MICA by microRNAs
    Takahiro Kishikawa
    1 Department of gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan 2
    Sci Rep 3:2739. 2013
    ..These data suggest that the modulation of MICA expression levels by miRNAs may be a useful method to regulate HCCs during hepatitis viral infection. ..
  42. doi request reprint A multicenter phase II trial of gemcitabine and candesartan combination therapy in patients with advanced pancreatic cancer: GECA2
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo, Japan, 113 8655
    Invest New Drugs 31:1294-9. 2013
    ..The aim of this multicenter phase II trial was to assess the efficacy and toxicity of gemcitabine and candesartan combination therapy for advanced pancreatic cancer...
  43. pmc Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis
    Hayato Nakagawa
    Department of Gastroenterology, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Proc Natl Acad Sci U S A 111:1090-5. 2014
    ..Thus, E-cadherin plays critical roles in maintaining homeostasis and suppressing carcinogenesis in the liver. ..
  44. pmc The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice
    Motoko Ohno
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Sci Rep 3:2553. 2013
    ..These results suggest that apigenin may have favorable effects on the pathogenic status induced by overexpression of miRNA103, whose maturation is mediated by phosphorylated TRBP. ..
  45. doi request reprint Uninodular combined hepatocellular and cholangiocarcinoma with multiple non-neoplastic hypervascular lesions appearing in the liver of a patient with HIV and HCV coinfection
    Koji Uchino
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Clin Virol 57:173-7. 2013
    ..The patient underwent partial hepatic resection and is currently alive without recurrence for 15 months. Multiple ring-enhanced lesions have been undetectable in postoperative follow-up CT examinations...
  46. pmc CT with hepatic arterioportography as a pretreatment examination for hepatocellular carcinoma patients: a randomized controlled trial
    Takamasa Ohki
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Gastroenterol 108:1305-13. 2013
    ..The combination of computed tomography with hepatic arteriography and arterial portography (CTHA/CTAP) can detect additional hepatocellular carcinoma (HCC) nodules undetected by conventional dynamic CT...
  47. pmc Improvement of prognosis for unresectable biliary tract cancer
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    World J Gastroenterol 19:72-7. 2013
    ..To evaluate the chemotherapeutic outcomes and confirm the recent improvement of prognosis for unresectable biliary tract cancer...
  48. doi request reprint Association between cigarette smoking and chronic kidney disease in Japanese men
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, and Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, Tokyo, Japan
    Hypertens Res 31:485-92. 2008
    ....
  49. ncbi request reprint A pilot study of salvage irinotecan monotherapy for advanced biliary tract cancer
    Takashi Sasaki
    Departments of 1Gastroenterology and 2Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Anticancer Res 33:2619-22. 2013
    ..To evaluate the treatment outcomes of irinotecan monotherapy for patients with advanced biliary tract cancer refractory to gemcitabine, cisplatin, and oral fluoropyrimidine...
  50. doi request reprint Role of intervention for biliary and gastric/intestinal obstruction in gastric cancer with peritoneal metastasis
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 27:1796-800. 2012
    ..The role of endoscopic or percutaneous interventions is not fully elucidated in this setting...
  51. doi request reprint Value of post-vascular phase (Kupffer imaging) by contrast-enhanced ultrasonography using Sonazoid in the detection of hepatocellular carcinoma
    Eriko Goto
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:477-85. 2012
    ....
  52. doi request reprint Long-term prognosis of autoimmune pancreatitis in terms of glucose tolerance
    Kenji Hirano
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Pancreas 41:691-5. 2012
    ..Glucose intolerance is often observed in autoimmune pancreatitis (AIP), although its long-term prognosis after steroid treatment (ST) is still unclear...
  53. doi request reprint Feasibility study of gemcitabine and cisplatin combination chemotherapy for patients with refractory biliary tract cancer
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Invest New Drugs 29:1488-93. 2011
    ..Two patients treated for approximately 1 year developed cisplatin-related toxicities. In conclusion, gemcitabine and cisplatin combination chemotherapy produces a limited tumor response in BTC, but may prolong patient's survival...
  54. ncbi request reprint Hepatitis C virus core protein exerts an inhibitory effect on suppressor of cytokine signaling (SOCS)-1 gene expression
    Hideyuki Miyoshi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Hepatol 43:757-63. 2005
    ..We studied the effect of the core protein of hepatitis C virus (HCV) on the expression of SOCS-1 gene...
  55. doi request reprint Newly designed large cell Niti-S stent for malignant hilar biliary obstruction: a pilot study
    Hirofumi Kogure
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Endosc 25:463-7. 2011
    ..This study evaluated the feasibility and efficacy of the Niti-S large cell D-type biliary stent (LCD) with a uniform large cell for both uni- and bilateral drainage of malignant hilar biliary obstruction...
  56. doi request reprint Clinical utility of an endoscopic ultrasound-guided rendezvous technique via various approach routes
    Kazumichi Kawakubo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Surg Endosc 27:3437-43. 2013
    ..We evaluated the clinical utility of an EUS-rendezvous technique using various approach routes...
  57. doi request reprint A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region
    Yuji Urabe
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Hepatol 58:875-82. 2013
    ..We performed a genome-wide association study (GWAS) of hepatitis C virus (HCV)-induced liver cirrhosis (LC) to identify predictive biomarkers for the risk of LC in patients with chronic hepatitis C (CHC)...
  58. doi request reprint Elevated plasma fibrinogen levels are associated with a poor prognosis in patients with hepatocellular carcinoma
    Akiyoshi Kinoshita
    Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital, Tokyo, Japan
    Oncology 85:269-77. 2013
    ..Elevated plasma fibrinogen levels are associated with tumor progression and poor outcomes in cancer patients. We investigated the prognostic value of pretreatment plasma fibrinogen levels in patients with hepatocellular carcinoma (HCC)...
  59. pmc Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis
    Hiroto Kinoshita
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 8:e60914. 2013
    ..Our results suggest the importance of IL-6 mediated stromal-epithelial cell interaction in gastric tumorigenesis...
  60. ncbi request reprint Role of type II topoisomerase mutations and AcrAB efflux pump in fluoroquinolone-resistant clinical isolates of Proteus mirabilis
    Ryoichi Saito
    Department of Infection Control and Prevention, The University of Tokyo Hospital, Tokyo, Japan
    J Antimicrob Chemother 58:673-7. 2006
    ..We conducted a study to determine the role played by amino acid mutations in DNA gyrase and topoisomerase IV, and the AcrAB efflux pump in resistance to fluoroquinolones in clinical isolates of Proteus mirabilis...
  61. ncbi request reprint Comparison of the impact of changes in waist circumference and body mass index in relation to changes in serum gamma-glutamyltransferase levels
    Aiko Sakamoto
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 20:142-51. 2013
    ..Here, the relationship was analyzed between changes in obesity parameters and those in serum GGT over a one-year period...
  62. doi request reprint High alcohol consumption increases the risk of pancreatic stone formation and pancreatic atrophy in autoimmune pancreatitis
    Kenji Hirano
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Pancreas 42:502-5. 2013
    ..This study aimed to investigate risk factors for pancreatic stones and atrophy in autoimmune pancreatitis (AIP)...
  63. doi request reprint Therapeutic effect of c-Jun N-terminal kinase inhibition on pancreatic cancer
    Ryota Takahashi
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo
    Cancer Sci 104:337-44. 2013
    ..Angiogenesis was also decreased by JNK inhibition in vitro and in vivo. In conclusion, activation of JNK promotes development of pancreatic cancer, and JNK may be a potential therapeutic target for pancreatic cancer...
  64. ncbi request reprint Risk factors and early signs of pancreatic cancer in diabetes: screening strategy based on diabetes onset age
    Suguru Mizuno
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
    J Gastroenterol 48:238-46. 2013
    ..Diabetes is expected to be a clue for the early detection of PaC; however, no effective screening strategy has been established...
  65. doi request reprint One-step, simultaneous triple endoscopic nasobiliary drainage for hilar biliary stricture
    Kazumichi Kawakubo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Dig Endosc 25:76-9. 2013
    ..One-step simultaneous triple ENBD is the most suitable drainage method for patients with advanced hilar biliary obstruction, especially in the setting of acute cholangitis due to occlusion of the previously placed stent...
  66. doi request reprint Evaluation of safety of endoscopic biopsy without cessation of antithrombotic agents in Japan
    Satoshi Ono
    Center for Epidemiology and Preventive Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo, Japan
    J Gastroenterol 47:770-4. 2012
    ..Therefore, we aimed to assess the feasibility of biopsy without cessation of antithrombotic agents in Japan...
  67. doi request reprint Uridine diphosphate glucuronosyl transferase 1 family polypeptide A1 gene (UGT1A1) polymorphisms are associated with toxicity and efficacy in irinotecan monotherapy for refractory pancreatic cancer
    Naminatsu Takahara
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Chemother Pharmacol 71:85-92. 2013
    ..The aim of this study was to evaluate the efficacy and safety of irinotecan monotherapy in patients with advanced pancreatic cancer (APC)...
  68. doi request reprint Endoscopic retrograde cholangiopancreatography for distal malignant biliary stricture
    Hiroyuki Isayama
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Gastrointest Endosc Clin N Am 22:479-90. 2012
    ....
  69. doi request reprint Endoscopic removal of a spontaneously fractured biliary uncovered self-expandable metal stent
    Kazumichi Kawakubo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Dig Endosc 24:182-4. 2012
    ..We should be aware that stent fracture can occur when placing uncovered biliary SEMSs in patients with a long life expectancy. EPLBD is very useful for retrieving the fractured fragment of SEMS...
  70. doi request reprint Evaluation of molecular targeted cancer drug by changes in tumor marker doubling times
    Kenichiro Enooku
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:71-8. 2012
    ..We evaluated the usefulness of tumor marker doubling time (DT) as an efficacy indicator of a molecular targeted anticancer agent...
  71. ncbi request reprint Alteration of intrahepatic cytokine expression and AP-1 activation in transgenic mice expressing hepatitis C virus core protein
    Takeya Tsutsumi
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Virology 304:415-24. 2002
    ..Thus, the altered in vivo expression of cytokines with AP-1 activation in consequence to the core protein expression may contribute to hepatocarcinogenesis in persistent HCV infection...
  72. ncbi request reprint Plant sterols increased IL-6 and TNF-α secretion from macrophages, but to a lesser extent than cholesterol
    Makoto Kurano
    Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Japan
    J Atheroscler Thromb 18:373-83. 2011
    ..In this study, we investigated whether phytosterols would affect inflammatory reactions in macrophages and macrophage cell lines...
  73. doi request reprint Endoscopic bilateral metallic stenting for malignant hilar obstruction using newly designed stents
    Hirofumi Kogure
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatobiliary Pancreat Sci 18:653-7. 2011
    ..Whether unilateral or bilateral drainage should be performed for malignant hilar biliary obstruction is controversial. Moreover, endoscopic placement of bilateral metallic stents is difficult and complicated...
  74. doi request reprint Reduced expression of RAS protein activator like-1 in gastric cancer
    Motoko Seto
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Cancer 128:1293-302. 2011
    ..Our findings demonstrate that reduced RASAL1 expression, partly due to genetic and epigenetic changes, contributes to gastric carcinogenesis, and also re-emphasize the importance of RAS signaling in gastric cancer development...
  75. doi request reprint Molecular characterizations of carbapenem and ciprofloxacin resistance in clinical isolates of Pseudomonas putida
    Wakako Kumita
    Department of Microbiology and Immunology, Graduate School of Health Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    J Infect Chemother 15:6-12. 2009
    ..putida...
  76. doi request reprint Endoscopic mucosal resection with a ligation device or endoscopic submucosal dissection for rectal carcinoid tumors: an analysis of 24 consecutive cases
    Keiko Niimi
    Department of Endoscopy and Endoscopic Surgery, The University of Tokyo, Tokyo, Japan
    Dig Endosc 24:443-7. 2012
    ..However, ESD is a complex procedure that requires advanced endoscopic skills. The aim of our study is to evaluate the efficacy of endoscopic mucosal resection with a ligation device (EMR-L) compared to ESD for rectal carcinoid tumors...
  77. pmc MicroRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression
    Akemi Takata
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Hepatology 57:162-70. 2013
    ..MiRNA-140-knockout mice were prone to hepatocarcinogenesis and had a phenotype similar to that of DDX20 deficiency, suggesting that miRNA-140 plays a central role in DDX20 deficiency-related pathogenesis...
  78. doi request reprint One- and two-step self-expandable metal stent placement for distal malignant biliary obstruction: a propensity analysis
    Tsuyoshi Hamada
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:1248-56. 2012
    ....
  79. pmc Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation
    Kosuke Sakitani
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Infect Immun 80:3795-803. 2012
    ..We also found that NF-κB activation was decreased in H. pylori-infected IL-32-knockdown cells. These results suggest that IL-32 has important functions in the regulation of cytokine expression in H. pylori-infected gastric mucosa...
  80. doi request reprint Acoustic radiation force impulse elastography for noninvasive assessment of chronic pancreatitis
    Yoko Yashima
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:427-32. 2012
    ....
  81. ncbi request reprint Serum level of adiponectin and the risk of liver cancer development in chronic hepatitis C patients
    Toru Arano
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655
    Int J Cancer 129:2226-35. 2011
    ..In conclusion, Patients who had CHC with high serum adiponectin levels had a higher risk of liver cancer development. Adiponectin may thus be tumorigenic or indicate a liver disease state independently of other clinical parameters...
  82. doi request reprint Clinical utility of single-operator cholangiopancreatoscopy using a SpyGlass probe through an endoscopic retrograde cholangiopancreatography catheter
    Kazumichi Kawakubo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 27:1371-6. 2012
    ..The aim of this pilot study was to clarify the clinical utility of single-operator cholangiopancreatoscopy using a SpyGlass probe through an endoscopic retrograde cholangiopancreatography (ERCP) catheter...
  83. doi request reprint Risk factors for pancreatitis following transpapillary self-expandable metal stent placement
    Kazumichi Kawakubo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Endosc 26:771-6. 2012
    ..Pancreatitis is one of complications after self-expandable metal stent (SEMS) placement. The purpose of this study was to evaluate risk factors for pancreatitis after endoscopic SEMS placement for malignant biliary obstruction (MBO)...
  84. doi request reprint Fever-based antibiotic therapy for acute cholangitis following successful endoscopic biliary drainage
    Hirofumi Kogure
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 46:1411-7. 2011
    ..We aimed to evaluate whether discontinuing antibiotic therapy for acute cholangitis immediately after the resolution of clinical symptoms, achieved by endoscopic biliary drainage, was safe and effective...
  85. doi request reprint Lower incidence of biliary carcinoma in patients with primary sclerosing cholangitis and high serum levels of immunoglobulin E
    Kenji Hirano
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Clin Gastroenterol Hepatol 10:79-83. 2012
    ..High serum levels of immunoglobulin (Ig)E often are detected in patients with primary sclerosing cholangitis (PSC), but the clinical significance is not known...
  86. doi request reprint A large volume of visceral adipose tissue leads to severe acute pancreatitis
    Yoko Yashima
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 46:1213-8. 2011
    ..Obesity plays an important role in acute pancreatitis. Assuming that the volume of visceral adipose tissue (VAT) directly influences the severity of acute pancreatitis, we investigated the relationship between VAT and acute pancreatitis...
  87. doi request reprint Association between chronic kidney disease and carotid intima-media thickening in individuals with hypertension and impaired glucose metabolism
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Hypertens Res 30:1035-41. 2007
    ....
  88. doi request reprint Gemcitabine and oxaliplatin combination chemotherapy for patients with refractory pancreatic cancer
    Hiroyuki Isayama
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Oncology 80:97-101. 2011
    ..The aim of this study was to investigate the effect of gemcitabine and oxaliplatin combination chemotherapy on refractory pancreatic cancer...
  89. doi request reprint Living donor liver transplantations in HIV- and hepatitis C virus-coinfected hemophiliacs: experience in a single center
    Kunihisa Tsukada
    Department of Infectious Diseases, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Transplantation 91:1261-4. 2011
    ....
  90. ncbi request reprint Relationship between the initial dose of micafungin and its efficacy in patients with candidemia
    Yasuo Ota
    Department of Infectious Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    J Infect Chemother 13:208-12. 2007
    ..Considering these results, we recommend the administration of 2.25 mg/kg/day or more of micafungin in the initial treatment of patients with candidemia...
  91. doi request reprint Changes in waist circumference and body mass index in relation to changes in serum uric acid in Japanese individuals
    Nobukazu Ishizaka
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Bunkyo ku, Tokyo, Japan
    J Rheumatol 37:410-6. 2010
    ..We investigated the relationship among percentage changes in waist circumference (%dWC), body mass index (%dBMI), and serum uric acid (%dUA)...
  92. ncbi request reprint Association between changes in obesity parameters and incidence of chronic kidney disease in Japanese individuals
    Yuko Ishizaka
    Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, Tokyo, Japan
    Kidney Blood Press Res 32:141-9. 2009
    ....
  93. doi request reprint Computed tomography follow-up for the detection of hepatocellular carcinoma recurrence after initial radiofrequency ablation: a single-center experience
    Shintaro Mikami
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Vasc Interv Radiol 23:1269-75. 2012
    ..This retrospective study compared the radiologic features of recurrent HCC seen by computed tomography (CT) to evaluate our empirical protocol of CT surveillance using 4-month intervals...
  94. pmc Silencing of microRNA-122 enhances interferon-α signaling in the liver through regulating SOCS3 promoter methylation
    Takeshi Yoshikawa
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Sci Rep 2:637. 2012
    ....
  95. doi request reprint Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence
    Yoko Soroida
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatol 57:330-6. 2012
    ..Mitochondrial isoenzyme of creatine kinase (MtCK) is reportedly highly expressed in hepatocellular carcinoma (HCC). Clinical relevance of serum MtCK activity in patients with HCC was assessed using a novel immuno-inhibition method...
  96. doi request reprint Sitafloxacin resistance in Helicobacter pylori isolates and sitafloxacin-based triple therapy as a third-line regimen in Japan
    Yoshihiro Hirata
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Antimicrob Agents 39:352-5. 2012
    ..These results suggest that STX could be active against most clinical H. pylori isolates and that STX-based triple therapy is a promising and safe third-line therapy...
  97. doi request reprint Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression
    Dai Mohri
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:203-13. 2012
    ..However, the molecular mechanisms of cancer progression from IPMN remain largely unknown. In this study we examined the differences in genetic alteration(s) among the IPMN subtypes...
  98. doi request reprint Endoscopic submucosal dissection is an effective and safe therapy for early gastric neoplasms: a multicenter feasible study
    Takafumi Sugimoto
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Gastroenterol 46:124-9. 2012
    ..The drawback of ESD is its technical difficulty and, consequently, its higher rate of complication. In this multicenter study, we investigated the therapeutic outcomes of ESD in consecutive patients...
  99. doi request reprint Hepatocarcinogenesis in hepatitis C: HCV shrewdly exacerbates oxidative stress by modulating both production and scavenging of reactive oxygen species
    Hidetake Fujinaga
    Department of Internal Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Oncology 81:11-7. 2011
    ..e. very frequent and multicentric development of HCC, in persistent HCV infection...
  100. doi request reprint Impact of introduction of wire-guided cannulation in therapeutic biliary endoscopic retrograde cholangiopancreatography
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 26:1552-8. 2011
    ..We assessed the learning curve for WGC in therapeutic biliary ERCP (study 1) and compared WGC and conventional contrast-assisted cannulation (CC) by a matched case-control study (study 2)...
  101. doi request reprint Prediction of hepatocellular carcinoma development by plasma ADAMTS13 in chronic hepatitis B and C
    Hitoshi Ikeda
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 20:2204-11. 2011
    ....