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Genomes and Genes | Shigeru KobayashiSummaryAffiliation: University of Fukui Country: Japan Publications
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Publications
Atlantoaxial subluxation-induced myelopathy in cleidocranial dysplasia. Case reportShigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, Fukui University School of Medicine, Fukui, Japan
J Neurosurg Spine 7:243-7. 2007..When managing cleidocranial dysplasia, the practitioner should always be aware that atlantoaxial subluxation may be the cause of cervical myelopathy...
Changes in nerve root motion and intraradicular blood flow during intraoperative femoral nerve stretch test. Report of four casesShigeru Kobayashi
Physiology Laboratory of Oxford University, Oxford, United Kingdom
J Neurosurg 99:298-305. 2003..An FNST was conducted in patients with lumbar disc herniation to observe the changes in IRBF, and results were then compared with clinical features...
Effect of lumbar nerve root compression on primary sensory neurons and their central branches: changes in the nociceptive neuropeptides substance P and somatostatinShigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, Fukui University School of Medicine, Fukui, Japan
Spine (Phila Pa 1976) 30:276-82. 2005..This study examined the effect of lumbar nerve root compression on nociceptive neuropeptides in the axonal flow using an in vivo model...
Changes of calcitonin gene-related peptide in primary sensory neurons and their central branch after nerve root compression of the dogShigeru Kobayashi
Department of Rehabilitation Medicine, Fukui University School of Medicine, Matsuoka, Fukui, Japan
Arch Phys Med Rehabil 86:527-33. 2005..To investigate changes in axonal flow after nerve root compression by using immunohistochemical techniques to detect calcitonin gene-related peptide (CGRP), which is thought to be involved in pain sensation...
Effect of mechanical compression on the lumbar nerve root: localization and changes of intraradicular inflammatory cytokines, nitric oxide, and cyclooxygenaseShigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, Fukui University School of Medicine, Matsuoka, Fukui, Japan
Spine (Phila Pa 1976) 30:1699-705. 2005..Investigation of intraradicular inflammation induced by mechanical compression...
Localization and changes of intraneural inflammatory cytokines and inducible-nitric oxide induced by mechanical compressionShigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, School of Medicine, Fukui Medical University, Shimoaizuki 23, Matsuoka, Fukui 910 1193, Japan
J Orthop Res 23:771-8. 2005..Investigation of intraneural inflammation induced by mechanical compression...
A case of nerve root heat injury induced by percutaneous laser disc decompression performed at an outside institution: technical case reportShigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, Fukui University School of Medicine, Fukui, Japan
Neurosurgery 60:ONSE171-2; discussion ONSE172. 2007..However, there is a risk of nerve root and endplate injury owing to heat generated by laser irradiation during PLDD. We recently performed salvage surgery on a patient with heat injury to the L5 nerve root that developed after PLDD...
Synapse involvement of the dorsal horn in experimental lumbar nerve root compression: a light and electron microscopic studyShigeru Kobayashi
Department of Orthopedic Surgery and Rehabilitation Medicine, Fukui University School of Medicine, Shimoaizuki, Matsuoka, Yoshida, Fukui, Japan
Spine (Phila Pa 1976) 33:716-23. 2008..This study was aimed at investigating changes in the dorsal horn of the lumbar cord induced by mechanical compression using an in vivo model...
Microvascular system of anterior cruciate ligament in dogsShigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, Fukui University School of Medicine, Shimoaizuki 23, Matsuoka, Fukui, 910 1193, and Department of Orthopedics, Kawasaki Municipal Hospital, Japan
J Orthop Res 24:1509-20. 2006..The clinical relevance of the fine vascular anatomy of the ACL in trauma surgery is considered. This deserves further consideration...
Motor neuron involvement in experimental lumbar nerve root compression: a light and electron microscopic studyShigeru Kobayashi
Department of Orthopedic Surgery and Rehabilitation Medicine, Fukui University School of Medicine, Fukui, Japan
Spine (Phila Pa 1976) 32:627-34. 2007..This study is to investigate the changes of lumbar motor neuron induced by mechanical nerve root compression using in vivo model...
A schwannoma of the S1 dural sleeve was resected while the intact nerve fibers were preserved using a microscope. Report of a case with early MRI findingsS Kobayashi
Department of Orthopedic Surgery, Fukui University School of Medicine, Matsuoka, Fukui, Japan
Minim Invasive Neurosurg 50:120-3. 2007..Microsurgery allowed the tumor to be removed with minimal impairment from cutting of nerve fibers in the nerve root...
Tumor necrosis factor-alpha and its receptors contribute to apoptosis of oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy) sustaining chronic mechanical compressionTomoo Inukai
Department of Orthopaedics and Rehabilitation Medicine, The University of Fukui, Fukui, Japan
Spine (Phila Pa 1976) 34:2848-57. 2009....
Changes in blood flow, oxygen tension, action potentials, and vascular permeability induced by arterial ischemia or venous congestion on the lumbar dorsal root ganglia in dogsShigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, The University of Fukui, Matsuoka, Fukui, Japan
J Neurotrauma 26:1167-75. 2009..From a clinical perspective, intraganglionic edema formation, rather than arterial ischemia, may be an earlier phenomenon inducing DRG dysfunction...
Herniated and spondylotic intervertebral discs of the human cervical spine: histological and immunohistological findings in 500 en bloc surgical samples. Laboratory investigationYasuo Kokubo
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Fukui, Japan
J Neurosurg Spine 9:285-95. 2008..In this paper the authors' goal was to identify histological and immunohistochemical differences between cervical disc hemrniation and spondylosis...
Blood flow analysis of compressed nerve root after intravenous injection of lipo-prostaglandin E1Shigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine Fukui, Faculty of Medical Sciences, The University of Fukui, Fukui, Japan
J Orthop Res 27:1252-7. 2009..It is concluded that lipo-PGE(1) has less effect on markedly degenerated nerve roots than it does on those that are normal...
Vertebroplasty-augmented short-segment posterior fixation of osteoporotic vertebral collapse with neurological deficit in the thoracolumbar spine: comparisons with posterior surgery without vertebroplasty and anterior surgeryKenzo Uchida
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Fukui, Japan
J Neurosurg Spine 13:612-21. 2010....
Target muscles for retrograde gene delivery to specific spinal cord segmentsHideaki Nakajima
Division of Orthopaedics and Rehabilitation Medicine, Department of Surgery, Faculty of Medical Sciences, University of Fukui, 23 3 Matsuokashimoaizuki, Eiheiji cho, Yoshida gun, Fukui 910 1193, Fukui, Japan
Neurosci Lett 435:1-6. 2008..Adenovirus vector is an efficient retrograde tracer since it can deliver the carried gene to a wide area of the spinal cord and not to other body organs...
Rescue of rat anterior horn neurons after spinal cord injury by retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor geneHideaki Nakajima
Division of Orthopaedics and Rehabilitation Medicine, Department of Surgery, University of Fukui Faculty of Medical Sciences, Fukui, Japan
J Neurotrauma 24:703-12. 2007..Our results suggest that in vivo targeted retrograde AdV-BDNF-gene delivery may enhance neuronal survival following traumatic injury of the spinal cord...
Rapidly progressive neuropathic arthropathy of the knee in possible association with a huge extruded cervical intervertebral disc herniationHideaki Nakajima
Department of Orthopaedics and Rehabilitation Medicine, University of Fukui Faculty of Medical Sciences, Shimoaizuki 23, Eiheiji Matsuoka, Fukui, 910 1193, Japan
Rheumatol Int 30:811-5. 2010..We stress the possibility of rapid progression of knee joint arthropathy, as neuropathic knee, even in a patient with less significant symptoms and signs of cervical myelopathy caused by a huge extruded intervertebral disc...
Vasomotion of intraradicular microvessels in ratShigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, The University of Fukui, Matsuoka, Fukui, Japan
Spine (Phila Pa 1976) 34:990-7. 2009..This study is to investigate the changes of vasomotion of intraradicular microvessels in vivo...
Microvascular system of the lumbar dorsal root ganglia in rats. Part II: neurogenic control of intraganglionic blood flowShigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, The University of Fukui, Matsuoka, FukuiJapan
J Neurosurg Spine 12:203-9. 2010..The authors used an immunohistochemical technique to investigate the presence and distribution of autonomic and sensory nerves in blood vessels of the DRG...
A phenotypic comparison of proteoglycan production of intervertebral disc cells isolated from rats, rabbits, and bovine tails; which animal model is most suitable to study tissue engineering and biological repair of human disc disorders?Tsuyoshi Miyazaki
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, The University of Fukui, Fukui, Japan
Tissue Eng Part A 15:3835-46. 2009..Animals with notochordal cells in the NP, such as rats and rabbits, may not provide good models for investigation of biological repair and tissue engineering for human disc disorders...
High-mobility group box-1 and its receptors contribute to proinflammatory response in the acute phase of spinal cord injury in ratsKe Bing Chen
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, The University of Fukui, Fukui, Japan
Spine (Phila Pa 1976) 36:2122-9. 2011..To examine the localization and expression of high-mobility group box-1 (HMGB-1) protein and its receptors after rat spinal cord injury...
Lidocaine cytotoxicity to the zygapophysial joints in rabbits: changes in cell viability and proteoglycan metabolism in vitroKenichi Takeno
Department of Orthopaedics and Rehabilitation Medicine, The University of Fukui, Matsuoka, Fukui, Japan
Spine (Phila Pa 1976) 34:E945-51. 2009..CONCLUSION.: While these in vitro results cannot be directly extrapolated to the clinical setting, this data suggestcaution in prolonged exposure of zygapophysial cartilage to high concentration lidocaine...
High-resolution magnetic resonance imaging and 18FDG-PET findings of the cervical spinal cord before and after decompressive surgery in patients with compressive myelopathyKenzo Uchida
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Fukui, Japan
Spine (Phila Pa 1976) 34:1185-91. 2009..Evaluation of cervical spinal cord (CSC) of patients with compressive myelopathy by magnetic resonance imaging (MRI) and high-resolution (18F)fluoro-deoxyglucose (18FDG) positron emission tomography (PET)...
Calcium pyrophosphate crystal deposition in the ligamentum flavum of degenerated lumbar spine: histopathological and immunohistological findingsTakafumi Yayama
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Shimoaizuki 23, Matsuoka, Fukui 910 1193, Japan
Clin Rheumatol 27:597-604. 2008..Calcium crystal deposition in the lumbar ligamentum flavum progresses with reduction in elastic fibers and accumulation of collagen fibrils in the matrix as well as expansion of chondrometaplastic areas...
Ultrastructural analysis on lumbar disc herniation using surgical specimens: role of neovascularization and macrophages in herniasShigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, The University of Fukui, Shimoaizuki 23, Matsuoka, Fukui, Japan
Spine (Phila Pa 1976) 34:655-62. 2009..The mechanisms responsible for the spontaneous regression of lumbar disc herniation (LDH) were studied by examining herniated tissue collected at operation from patients with LDH...
Effects of arterial ischemia and venous congestion on the lumbar nerve root in dogsShigeru Kobayashi
Faculty of Medical Sciences, Department of Orthopaedics and Rebhailitation Medicine, The University of Fukui, 23 3 Shimozizuki, Matsuoka, Eiheiji, Fukui, Japan
J Orthop Res 26:1533-40. 2008..In conclusion, venous congestion may be an essential factor precipitating circulatory disturbance in compressed nerve roots and inducing neurogenic intermittent claudication...
Targeted retrograde gene delivery of brain-derived neurotrophic factor suppresses apoptosis of neurons and oligodendroglia after spinal cord injury in ratsHideaki Nakajima
Department of Orthopaedics and Rehabilitation Medicine, The University of Fukui, Fukui, Japan
Spine (Phila Pa 1976) 35:497-504. 2010..Histologic and immunohistochemical studies after targeted retrograde adenovirus (AdV)-mediated brain-derived neurotrophic factor (BDNF) gene delivery via intramuscular injection in rats with injured spinal cord...
Exceedingly large femoral condyle intraosseous ganglion cyst following high tibial osteotomyChikara Kubota
Department of Surgery, Faculty of Medical Sciences, University of Fukui, Shimoaizuki 23, Matsuoka, Fukui, 910-1193, Japan
J Orthop Sci 12:592-6. 2007
Fine structure of cartilage canal and vascular buds in the rabbit vertebral endplate. Laboratory investigationShigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, The University of Fukui, Matsuoka, Fukui, Japan
J Neurosurg Spine 9:96-103. 2008..The purpose of this study was to clarify the ultrastructure of the vascular bud seen in the bone-disc junction in comparison to the cartilage canal...
Cervical spondylotic myelopathy associated with kyphosis or sagittal sigmoid alignment: outcome after anterior or posterior decompressionKenzo Uchida
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Eiheiji, Fukui, Japan
J Neurosurg Spine 11:521-8. 2009..The aim in this study was to determine the effects of kyphotic sagittal alignment of the cervical spine in terms of neurological morbidity and outcome after 2 types of surgical intervention...
Lidocaine cytotoxicity to the bovine articular chondrocytes in vitro: changes in cell viability and proteoglycan metabolismTsuyoshi Miyazaki
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, The University of Fukui, Shimoaizuki 23, Matsuoka, Fukui 910 1193, Japan
Knee Surg Sports Traumatol Arthrosc 19:1198-205. 2011..This study was performed to determine the effects of varying concentrations and exposure times of lidocaine on the viability and proteoglycan metabolism of chondrocytes in vitro...
Quantitative gait analysis of patients with bilateral hip osteoarthritis excluding the influence of walking speedMasafumi Kubota
Division of Physical Therapy and Rehabilitation Medicine, University of Fukui Hospital, 23 Matsuoka Shimoaizuki, Eiheiji, Fukui, 910 1193, Japan
J Orthop Sci 12:451-7. 2007..The purpose of this study was to investigate gait characteristics of patients with bilateral hip osteoarthritis (BHO) independent of walking speed...
Gene expression profiles of neurotrophic factors in rat cultured spinal cord cells under cyclic tensile stressKenzo Uchida
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Fukui, Japan
Spine (Phila Pa 1976) 33:2596-604. 2008..An experimental study to investigate the in vitro gene expression of neurotrophic factors and receptors in cultured rat spinal cord cells subjected to cyclic mechanical stretch forces...
Pathogenesis of the discal cysts communicating with an adjacent herniated disc. Histological and ultrastructual studies of two casesShigeru Kobayashi
Faculty of Medical Science, Department of Orthopaedics and Rehabilitation Medicine, 23 3 Shimoaizuki, Matsuoka, Eiheiji, Fukui, 910 1193 Japan
Joint Bone Spine 77:184-6. 2010..In this study, we confirmed that the discal cyst could have developed from the absorption process of a disc herniation...
Microvascular system of the lumbar dorsal root ganglia in rats. Part I: a 3D analysis with scanning electron microscopy of vascular corrosion castsShigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, The University of Fukui, Matsuoka, Fukui, Japan
J Neurosurg Spine 12:197-202. 2010..However, in the past most of these studies lacked 3D observations. This study presents the details of the microvasculature of the lumbar DRG visualized by scanning electron microscopy of vascular corrosion casts...
Salvage operation for persistent low back pain and sciatica induced by percutaneous laser disc decompression performed at outside institution: correlation of magnetic resonance imaging and intraoperative and pathological findingsKenichi Takeno
Department of Orthopaedics and Rehabilitation Medicine, Fukui University School of Medicine, Fukui, and Aikou Orthopaedic Clinic, Aichi, Japan
Photomed Laser Surg 24:414-23. 2006..Our findings highlight the need for careful diagnosis and sufficient technical skill when selecting PLDD as a treatment option...
Anterior expandable strut cage replacement for osteoporotic thoracolumbar vertebral collapseKenzo Uchida
Department of Orthopedics and Rehabilitation Medicine, Fukui University School of Medicine, Fukui, Japan
J Neurosurg Spine 4:454-62. 2006..The authors investigated the usefulness of using an expandable cage strut in anterior reconstruction after osteoporotic vertebral collapse in patients with neurological deficits...
Physical limitations to tissue engineering of intervertebral disc cells: effect of extracellular osmotic change on glycosaminoglycan production and cell metabolism. Laboratory investigationKenichi Takeno
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Science, The University of Fukui, Fukui, Japan
J Neurosurg Spine 7:637-44. 2007..In this study, the authors examined how physiological levels of extracellular osmolality influence proteoglycan accumulation in nucleus pulposus cells in a 3D culture system...
Effects of graded mechanical compression of rabbit sciatic nerve on nerve blood flow and electrophysiological propertiesTakafumi Yayama
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Matsuoka Shimoaizuki 23, Eiheiji, Fukui 910 1193, Japan
J Clin Neurosci 17:501-5. 2010..These changes may be critical factors in the development of symptoms associated with nerve compression...
Metaphyseal-loading anterolaterally-flared femoral stem in cementless total hip arthroplasty: five- to eleven-year follow-up evaluationHideo Kawahara
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, The University of Fukui, Matsuoka Shimoaizuki 23, Eiheiji, Fukui, Japan
Artif Organs 34:377-83. 2010..Our analysis confirmed reduced radiolucency around the stem in Gruen zones, minimal subsidence, appropriate stress shielding, and promising medium-term stability within the femoral canal in our patients...
Visualization of intraneural edema using gadolinium-enhanced magnetic resonance imaging of carpal tunnel syndromeShigeru Kobayashi
Department of Orthopedics and Rehabilitation Medicine, Fukui University School of Medicine, 23 Shimoaizuki, Matsuoka, Fukui, 910 1193, Japan
J Orthop Sci 14:24-34. 2009..Therefore, detecting intraneural edema may be a way of diagnosing entrapment neuropathy. The present study investigated the diagnostic role of gadolinium-enhanced MR imaging of CTS...
Effects of alendronate on bone metabolism in glucocorticoid-induced osteoporosis measured by 18F-fluoride PET: a prospective studyKenzo Uchida
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
J Nucl Med 50:1808-14. 2009....
Adenovirus-mediated retrograde transfer of neurotrophin-3 gene enhances survival of anterior horn neurons of twy/twy mice with chronic mechanical compression of the spinal cordKenzo Uchida
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Matsuoka, Fukui, Japan
J Neurosci Res 86:1789-800. 2008..Our results suggest that targeted retrograde NT-3 gene delivery is feasible in the intact animal and that it enhances neuronal survival even under chronic mechanical compression of the spinal cord...
Multivariate analysis of the neurological outcome of surgery for cervical compressive myelopathyKenzo Uchida
Division of Orthopaedics and Rehabilitation Medicine, Department of Surgery, Faculty of Medicine, University of Fukui, 23 Shimoaizuki, Matsuoka, Fukui, 910-1193, Japan
J Orthop Sci 10:564-73. 2005..CONCLUSIONS: We suggest that multivariate analysis is useful for assessing the neurosurgical outcome in patients with cervical compressive myelopathy...
Tumor necrosis factor-α antagonist reduces apoptosis of neurons and oligodendroglia in rat spinal cord injuryKe Bing Chen
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Japan
Spine (Phila Pa 1976) 36:1350-8. 2011..To examine the effects of a tumor necrosis factor (TNF)-α antagonist (etanercept) on rat spinal cord injury and identify a possible mechanism for its action...
Microarray analysis of expression of cell death-associated genes in rat spinal cord cells exposed to cyclic tensile stresses in vitroKenzo Uchida
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Shimoaizuki 23, Matsuoka, Fukui 910 1193, Japan
BMC Neurosci 11:84. 2010..Changes in expression of 12 genes were validated with quantitative real-time reverse transcription polymerase chain reaction (RT-PCR)...
Intraneural blood flow analysis during an intraoperative Phalen's test in carpal tunnel syndromeTakafumi Yayama
Faculty of Medical Sciences, University of Fukui, 23 3, Shimoaizuki, Matsuoka, Eiheiji, Fukui, Japan 910 1193
J Orthop Res 28:1022-5. 2010..After carpal tunnel release, there was no marked decrease in intraneural blood flow. This study demonstrated that the blood flow in the median nerve is reduced when Phalen's test is performed in vivo...
Immunohistochemical findings of multiple ossified en plaque meningiomas in the thoracic spineKenzo Uchida
Department of Orthopaedics and Rehabilitation Medicine, Fukui University, Faculty of Medical Sciences, Matsuoka Shimoaizuki 23, Eiheiji, Fukui 910 1193, Japan
J Clin Neurosci 16:1660-2. 2009..Immunostaining for bone morphogenetic protein-2 and vascular endothelial growth factor was significantly positive in the areas surrounding mature bone tissues in the metaplastic and psammomatous subtypes...
Epidural abscess associated with pyogenic spondylodiscitis of the lumbar spine; evaluation of a new MRI staging classification and imaging findings as indicators of surgical management: a retrospective study of 37 patientsKenzo Uchida
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Matsuoka Shimoaizuki 23, Eiheiji, Fukui 910 1193, Japan
Arch Orthop Trauma Surg 130:111-8. 2010....
Thoracic ossification of the human ligamentum flavum: histopathological and immunohistochemical findings around the ossified lesionTakafumi Yayama
Departments of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Fukui, Japan
J Neurosurg Spine 7:184-93. 2007....
Anterior versus posterior surgery for osteoporotic vertebral collapse with neurological deficit in the thoracolumbar spineKenzo Uchida
Department of Orthopaedics and Rehabilitation Medicine, Department of Surgery, Fukui University School of Medicine, Shimoaizuki 23, Matsuoka, Fukui, Japan
Eur Spine J 15:1759-67. 2006..In single-level osteoporotic vertebral collapse with neurological deficit, anterior surgery tended to improve neurological deficit in wedge type, but not in flat type collapse, compared with posterior surgery...
Ossification process involving the human thoracic ligamentum flavum: role of transcription factorsKenzo Uchida
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, Fukui University, Eiheiji, Fukui 910 1193, Japan
Arthritis Res Ther 13:R144. 2011..The objective of this study was to investigate the pathomechanism of the ossification process, including the roles of various transcriptional factors in the ossification of human thoracic ligamentum flavum...
Pathomechanisms of sciatica in lumbar disc herniation: effect of periradicular adhesive tissue on electrophysiological values by an intraoperative straight leg raising testShigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, The University of Fukui, Fukui, Japan
Spine (Phila Pa 1976) 35:2004-14. 2010..This study is aimed to investigate the changes of nerve root functions during the straight leg raising (SLR) test in vivo...
Anterior and posterior decompressive surgery for progressive amyotrophy associated with cervical spondylosis: a retrospective study of 51 patientsKenzo Uchida
Department of Orthopaedics and Rehabilitation Medicine, University of Fukui Faculty of Medical Sciences, Fukui, Japan
J Neurosurg Spine 11:330-7. 2009....
Metabolic neuroimaging of the cervical spinal cord in patients with compressive myelopathy: a high-resolution positron emission tomography studyKenzo Uchida
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medicine, and Biomedical Imaging Research Center, University of Fukui, Matsuoka, Fukui, Japan
J Neurosurg Spine 1:72-9. 2004....
[Blood circulation of cauda equina and nerve root]Shigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, Fukui University School of Medicine
Clin Calcium 15:63-72. 2005..In this article, we have reviewed about the blood circulation of cauda equina and nerve root under normal and pathologic conditions...
Microsurgical excision of hematoma of the lumbar ligamentum flavumKenichi Takeno
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Science, and Research and Education Program for Life Science, The University of Fukui, Fukui, Japan
Joint Bone Spine 77:351-4. 2010....
Development of a chronic cervical cord compression model in rat: changes in the neurological behaviors and radiological and pathological findingsMasafumi Kubota
Faculty of Medical Sciences, The University of Fukui, Department of Orthopaedics and Rehabilitation Medicine, Fukui, Japan
J Neurotrauma 28:459-67. 2011....
Effects of disease severity on response to lateral wedged shoe insole for medial compartment knee osteoarthritisSeiichiro Shimada
Gait Analysis Laboratory, Division of Physical Therapy and Rehabilitation, Fukui University Hospital, Fukui, Japan
Arch Phys Med Rehabil 87:1436-41. 2006..To determine the effects of lateral wedged insoles on knee kinetics and kinematics during walking, according to radiographic severity of medial compartment knee osteoarthritis (OA)...
Motion analysis of the wrist joints in patients with rheumatoid arthritisTakafumi Yayama
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, 23 Matsuoka Shimoaizuki, Eiheiji, Fukui, 910 1193, Japan
Mod Rheumatol 17:322-6. 2007..Our results indicate that disturbed coupling of FE and RUD results in difficulties in the cooperative movements and have great influence on the daily activities in RA wrist joint...
Successful treatment of nonclostridial gas gangrene extending from retroperitoneum to thigh associated with occult cecal cancerShigeru Kobayashi
Department of Orthopaedics, Fukui University School of Medicine, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Fukui, 910-1193, Japan
J Orthop Sci 12:585-91. 2007
Changes in nerve root motion and intraradicular blood flow during an intraoperative straight-leg-raising testShigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, Fukui University School of Medicine, Fukui, Japan
Spine (Phila Pa 1976) 28:1427-34. 2003..An intraoperative straight-leg-raising (SLR) test was conducted to investigate patients with lumbar disc herniation to observe the changes in intraradicular blood flow, which then were compared with the clinical features...
Anterior spinal artery syndrome complicating massive paravertebral abscessKenzo Uchida
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Matsuoka, Fukui, Japan
J Orthop Sci 13:85-8. 2008
Targeted retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor gene prevents loss of mouse (twy/twy) anterior horn neurons in vivo sustaining mechanical compressionKan Xu
Division of Orthopaedics and Rehabilitation Medicine, Department of Surgery, University of Fukui Faculty of Medicine, Matsuoka, Fukui, Japan
Spine (Phila Pa 1976) 31:1867-74. 2006..Immunohistochemical analysis after adenovirus (AdV)-mediated BDNF gene transfer in and around the area of mechanical compression in the cervical spinal cord of the hyperostotic mouse (twy/twy)...
Calcium pyrophosphate dehydrate crystal deposition in the ligamentum flavum of the cervical spine: histopathological and immunohistochemical findingsE S Mwaka
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, The University of Fukui, Fukui 910 1193, Japan
Clin Exp Rheumatol 27:430-8. 2009..To investigate the histopathological and immunohistochemical properties of degenerative changes in the ligamentum flavum of the cervical spine with calcium crystal deposition...
Targeted retrograde gene delivery into the injured cervical spinal cord using recombinant adenovirus vectorHideaki Nakajima
Division of Orthopaedics and Rehabilitation Medicine, Department of Surgery, School of Medicine, University of Fukui, Shimoaizuki 23, Matsuoka, Fukui 910 1193, Japan
Neurosci Lett 385:30-5. 2005....
Metastatic involvement of sacral nerve roots from uterine carcinoma: a case reportKenzo Uchida
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Shimoaizuki 23, Matsuoka, Fukui 910 1193, Japan
Spine J 8:849-52. 2008..It is also possible that perineural and endoneural invasion occur in presacral local recurrence. Little is reported about metastasis in pelvic lesions including sacral nerve roots...
Dynamic analysis of the resultant force acting on the hip joint during level walkingNaoki Hashimoto
Division of Orthopaedics and Rehabilitation Medicine, Department of Surgery, University of Fukui Faculty of Medicine, Matsuoka, Fukui, Japan
Artif Organs 29:387-92. 2005..Our results suggest that muscle strength and walking speed are significant determinants of the resultant force acting on the hip...
Ossification of the posterior longitudinal ligament of the cervical spine: histopathological findings around the calcification and ossification frontRyuichiro Sato
Division of Orthopaedics and Rehabilitation Medicine, Department of Surgery, Faculty of Medical Sciences, The University of Fukui, Japan
J Neurosurg Spine 7:174-83. 2007..The authors studied the histological and immunohistochemical features of ossified posterior longitudinal ligament (PLL) of the cervical spine, especially in the calcification and ossification front...
Microsurgical excision of ganglioneuroma arising from the C8 nerve root within the neuroforamenK Uchida
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Fukui, Japan
Minim Invasive Neurosurg 50:350-4. 2007....
Imaging of cauda equina edema in lumbar canal stenosis by using gadolinium-enhanced MR imaging: experimental constriction injuryS Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, Fukui University School of Medicine, Matsuoka, Fukui, Japan
AJNR Am J Neuroradiol 27:346-53. 2006..CONCLUSION: Gadolinium-enhanced MR imaging may be a useful tool for the diagnosis of microcirculatory disorders of the cauda equina associated with LSCS...
Herniation of cervical intervertebral disc: immunohistochemical examination and measurement of nitric oxide productionN Furusawa
Departmenr of Orthopaedic Surgerey, School of Medicine, Fukui Medical University, Fukui, Japan
Spine (Phila Pa 1976) 26:1110-6. 2001..Surgically obtained cervical herniated intervertebral discs were examined histologically and immunohistochemically. The production of nitric oxide (NO) in the local tissue was examined using the electron spin resonance (ESR) method...
Plasticity of the spinal cord contributes to neurological improvement after treatment by cervical decompression. A magnetic resonance imaging studyH Baba
Department of Orthopaedic Surgery, Fukui Medical School, Japan
J Neurol 244:455-60. 1997....
Spontaneous remission of a solitary intraspinal synovial cyst of the lumbar spineY Maezawa
Department of Orthopaedic Surgery, School of Medicine, Fukui Medical University, Matsuoka, Japan
Eur Spine J 9:85-7. 2000..Conservative treatment for several months may be one treatment option if the cyst wall is not calcified and the symptoms and signs related to radiculopathy show a gradual decrease...
Ligamentum flavum hematoma in the thoracic spineY Maezawa
Department of Orthopaedic Surgery, School of Medicine, Fukui Medical University, Shimoaizuki 23, Matsuoka, Fukui 910 1193, Japan
Clin Imaging 25:265-7. 2001..The resected T11 and T12 laminas showed old hematoma with degenerative changes in the ligamentum flavum. Hematoma occurring in the thoracic spine has never been reported previously...
Histological investigation of spinal cord lesions in the spinal hyperostotic mouse (twy/twy): morphological changes in anterior horn cells and immunoreactivity to neurotropic factorsK Uchida
Department of Orthopaedic Surgery, School of Medicine, Fukui Medical University, Matsuoka, Japan
J Neurol 245:781-93. 1998..We speculate that the presence of BDNF and NT-3 in neurons and astrocyte-like cells is proportionate to the severity of chronic mechanical compression and may contribute to the heterotropic neuronal reserve and survival...
Pathogenesis of calcium crystal deposition in the ligamentum flavum correlates with lumbar spinal canal stenosisT Yayama
Division of Orthopaedics and Rehabilitation Medicine, Department of Surgery, University of Fukui, Faculty of Medical Sciences, Shimoaizuki 23, Matsuoka, Fukui, Japan
Clin Exp Rheumatol 23:637-43. 2005..To investigate the histological and immunohistochemical properties of degenerative changes and calcium crystal deposition in the lumbar ligamentum favum...
Lordotic alignment and posterior migration of the spinal cord following en bloc open-door laminoplasty for cervical myelopathy: a magnetic resonance imaging studyH Baba
Department of Orthopaedic Surgery, Fukui Medical School, Japan
J Neurol 243:626-32. 1996..01). Our results suggest that a significant neurological improvement is associated with posterior cord migration after cervical laminoplasty...
Microsurgical intraneural extracapsular resection of neurinoma around the cervical neuroforamen: a technical noteK Uchida
Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Fukui, Japan
Minim Invasive Neurosurg 52:271-4. 2009....
Imaging of intraneural edema by using gadolinium-enhanced MR imaging: experimental compression injuryShigeru Kobayashi
Physiology Laboratory of Oxford University, Oxford, United Kingdom
AJNR Am J Neuroradiol 26:973-80. 2005..CONCLUSION: Gadolinium-enhanced MR imaging can detect morphologic and functional changes of blood-nerve barrier in the nerve induced by mechanical compression...
Effect of cell density on the rate of glycosaminoglycan accumulation by disc and cartilage cells in vitroShigeru Kobayashi
Department of Physiology, Anatomy, and Genetics, Oxford University, Oxford, United Kingdom
J Orthop Res 26:493-503. 2008....
Gait analysis of spastic walking in patients with cervical compressive myelopathyY Maezawa
Department of Orthopaedic Surgery, Fukui Medical University, Shimoaizuki 23, Matsuoka, Fukui 910-1193, Japan
J Orthop Sci 6:378-84. 2001..Our results show that kinesiological gait analysis is clinically useful for the functional assessment of the severity of spastic walking in cervical myelopathy...
Microsurgical excision of multiple clear cell meningiomas of the cauda equina: a case reportH Nakajima
Department of Orthopaedics and Rehabilitation Medicine, University of Fukui Faculty of Medical Sciences, Yoshida gun, Fukui, Japan
Minim Invasive Neurosurg 52:32-5. 2009..Histopathological diagnosis was clear cell meningioma...
Insidious progression of paraparesis secondary to type III spinal meningeal cyst: a study of six difficult casesT Yayama
Faculty of Medical Sciences, Department of Orthopaedics and Rehabilitation Medicine, Fukui University, Fukui, Japan
Spinal Cord 46:159-61. 2008..Case report...
Primary osteosarcoma of the thoracic spine: report of an unusual elderly patient with autopsy findingsY Kokubo
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medicine, Fukui University, Matsuoka, Fukui, Japan
Spinal Cord 43:508-11. 2005..We should always consider this rare entity, particularly in elderly patients who present with back pain and vertebral collapse...
Parosteal aneurysmal bone cyst of the humerus with birdcage-like ossification on three-dimensional CT scanning: a case reportShigeru Kobayashi
Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, The University of Fukui, Shimoaizuki 23, Matsuoka, Fukui, 910 1193, Japan
Joint Bone Spine 76:705-7. 2009..The tumor was excised en bloc with a clear margin. At 3 years after surgery, there is no evidence of recurrent tumor...
Sodium sensitivity and sympathetic nervous system in hypertension induced by long-term nitric oxide blockade in ratsS Yuasa
Second Department of Internal Medicine, School of Medicine, Kagawa Medical University, Japan
Clin Exp Pharmacol Physiol 27:18-24. 2000....
Cervical angina: a seemingly still neglected symptom of cervical spine disorder?H Nakajima
Division of Orthopaedics and Rehabilitation Medicine, Department of Surgery, School of Medicine, University of Fukui, Japan
Spinal Cord 44:509-13. 2006..Retrospective, case series...
Effect of osmolarity on glycosaminoglycan production and cell metabolism of articular chondrocyte under three-dimensional culture systemK Negoro
Department of Orthopaedics and Rehabilitation Medicine, Fukui University School of Medicine, Fukui, Japan
Clin Exp Rheumatol 26:534-41. 2008..This study examined how physiological levels of extracellular osmolarity influence proteoglycan accumulation in articular chondrocytes in a three-dimensional culture system...
Potential usefulness of 18F-2-fluoro-deoxy-D-glucose positron emission tomography in cervical compressive myelopathyH Baba
Department of Orthopaedic Surgery, School of Medicine, Fukui Medical University, Japan
Spine (Phila Pa 1976) 24:1449-54. 1999..18FDG-PET images may also offer additional information related to neuronal dysfunction induced by mechanical compression...
Retroperitoneal lymphocele associated with lumbar spine fracture: report of an unusual caseR Sato
Department of Orthopaedic Surgery, School of Medicine, Fukui University, Fukui, Japan
Spinal Cord 43:687-90. 2005..CONCLUSION:Physicians should be aware that such unusual retroperitoneal lymphocele might develop even after a blunt ureteral injury or a minor lumbar spine fracture...
Intravenous injection of high and medium concentrations of computed tomography contrast media and related heat sensation, local pain, and adverse reactionsTakayuki Masui
Department of Radiology, Seirei Hamamatsu General Hospital, Shizuoka, Japan
J Comput Assist Tomogr 29:704-8. 2005..To evaluate the incidence of acute adverse reactions and degrees of heat sensation and local pain after intravenous injection of high and medium concentrations of iodinated contrast medium for computed tomography (CT)...
Effect of mechanical compression on the vascular permeability of the dorsal root ganglionShigeru Kobayashi
Department of Orthopedics, Fujita Health, University School of Medicine, Toyoake, Aichi, Japan
J Orthop Res 20:730-9. 2002..It was proven that the increased vascular permeability occurred as well as in leakage of dye within the dorsal root ganglion after a single hour of compression of the dorsal root ganglion...
Pathology of lumbar nerve root compression. Part 2: morphological and immunohistochemical changes of dorsal root ganglionShigeru Kobayashi
Department of Orthopaedics, Fujita Health University, School of Medicine, 1 98, Dengakugakubo, Kutukake cho, Toyoake, Aichi 470 1192, Japan corrected
J Orthop Res 22:180-8. 2004..This study is to investigate the changes of dorsal root ganglion (DRG) induced by mechanical compression using in vivo model...
Neuropeptide substance P stimulates the formation of osteoclasts via synovial fibroblastic cellsTakaaki Matayoshi
Division of Oral and Maxillofacial Reconstructive Surgery, Kyushu Dental College, Kitakyushu 803-8580, Japan
Biochem Biophys Res Commun 327:756-64. 2005..These results suggest that SP in the joint cavity may cause both hypertrophy of the synovium and induction of increased osteoclast formation through the increased expression of RANKL in the synovium...
Pathology of lumbar nerve root compression. Part 1: Intraradicular inflammatory changes induced by mechanical compressionShigeru Kobayashi
Department of Orthopaedics, Fujita Health University, School of Medicine, 1 98, Dengakugakubo, Kutukake cho, Toyoake, Aichi 470 1192, Japan corrected
J Orthop Res 22:170-9. 2004..This study is to investigate the intraradicular inflammation induced by mechanical compression using in vivo model...
Diffusion-weighted echo planar imaging of ovarian tumors: is it useful to measure apparent diffusion coefficients?Motoyuki Katayama
Department of Radiology, Seirei Hamamatsu General Hospital, Japan
J Comput Assist Tomogr 26:250-6. 2002....
Long-term follow-up and knee osteoarthritis change after medial patellofemoral ligament reconstruction for recurrent patellar dislocationEiki Nomura
Department of Orthopaedic Surgery, Saitama Municipal Hospital, 2460, Mimuro, Midori ku, Saitama 336 8522, Japan
Am J Sports Med 35:1851-8. 2007..A new approach, medial patellofemoral ligament reconstruction, has recently started, but there have been no reports on the long-term follow-up...
Laparoscopic cholecystectomy after coronary artery bypass grafting using the right gastroepiploic artery: report of a caseKazuhiro Sakamoto
First Department of Surgery, Juntendo University, School of Medicine, Tokyo, Japan
Surg Today 32:840-3. 2002..It is difficult to view the operating field and the RGEA pedicle together. It is therefore better to insert another laparoscope for concomitant monitoring of the RGEA pedicle...
