I Kobayashi

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc A putative mobile genetic element carrying a novel type IIF restriction-modification system (PluTI)
    Feroz Khan
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Japan
    Nucleic Acids Res 38:3019-30. 2010
  2. pmc IS-linked movement of a restriction-modification system
    Noriko Takahashi
    Laboratory of Social Genome Science, Department of Medical Genome Sciences, Graduate School of Frontier Science, University of Tokyo, Minato ku, Tokyo, Japan
    PLoS ONE 6:e16554. 2011
  3. pmc Movement of DNA sequence recognition domains between non-orthologous proteins
    Yoshikazu Furuta
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Minato ku, Tokyo, 108 8639, Japan
    Nucleic Acids Res 40:9218-32. 2012
  4. pmc Genome-wide survey of mutual homologous recombination in a highly sexual bacterial species
    Koji Yahara
    Division of Biostatistics, Graduate School of Medicine, Kurume University, Fukuoka, Japan
    Genome Biol Evol 4:628-40. 2012
  5. pmc Large variations in bacterial ribosomal RNA genes
    Kyungtaek Lim
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Minato ku, Tokyo, Japan
    Mol Biol Evol 29:2937-48. 2012
  6. pmc Evolution of cagA oncogene of Helicobacter pylori through recombination
    Yoshikazu Furuta
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Minato ku, Tokyo, Japan
    PLoS ONE 6:e23499. 2011
  7. pmc Cleavage of a model DNA replication fork by a methyl-specific endonuclease
    Ken Ishikawa
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Shirokanedai, Tokyo 108 8639, Japan
    Nucleic Acids Res 39:5489-98. 2011
  8. pmc Antisense RNA associated with biological regulation of a restriction-modification system
    Iwona Mruk
    Department of Microbiology, University of Gdansk, Kladki 24, Gdansk, 80 822, Poland
    Nucleic Acids Res 39:5622-32. 2011
  9. pmc Multiple genome comparison within a bacterial species reveals a unit of evolution spanning two adjacent genes in a tandem paralog cluster
    Takeshi Tsuru
    Laboratory of Social Genome Sciences, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan
    Mol Biol Evol 25:2457-73. 2008
  10. pmc Discovery of a novel restriction endonuclease by genome comparison and application of a wheat-germ-based cell-free translation assay: PabI (5'-GTA/C) from the hyperthermophilic archaeon Pyrococcus abyssi
    Ken Ishikawa
    Department of Medical Genome Sciences, Graduate School of Frontier Science, University of Tokyo 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nucleic Acids Res 33:e112. 2005

Collaborators

Detail Information

Publications57

  1. pmc A putative mobile genetic element carrying a novel type IIF restriction-modification system (PluTI)
    Feroz Khan
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Japan
    Nucleic Acids Res 38:3019-30. 2010
    ..These results suggested that they constitute a restriction-modification system, present on the putative mobile element. Our approach thus allowed detection of a previously uncharacterized family of DNA-interacting proteins...
  2. pmc IS-linked movement of a restriction-modification system
    Noriko Takahashi
    Laboratory of Social Genome Science, Department of Medical Genome Sciences, Graduate School of Frontier Science, University of Tokyo, Minato ku, Tokyo, Japan
    PLoS ONE 6:e16554. 2011
    ..This collaboration may have promoted the spread and, therefore, the long-term persistence of these complexes and restriction-modification systems in a wide range of prokaryotes...
  3. pmc Movement of DNA sequence recognition domains between non-orthologous proteins
    Yoshikazu Furuta
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Minato ku, Tokyo, 108 8639, Japan
    Nucleic Acids Res 40:9218-32. 2012
    ..One of these RM systems in H. pylori was inactivated by insertion of another RM system that likely transferred from an oral bacterium. TRD movement represents a novel route for diversification of DNA-interacting proteins...
  4. pmc Genome-wide survey of mutual homologous recombination in a highly sexual bacterial species
    Koji Yahara
    Division of Biostatistics, Graduate School of Medicine, Kurume University, Fukuoka, Japan
    Genome Biol Evol 4:628-40. 2012
    ....
  5. pmc Large variations in bacterial ribosomal RNA genes
    Kyungtaek Lim
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Minato ku, Tokyo, Japan
    Mol Biol Evol 29:2937-48. 2012
    ..These results open the way to understanding dynamic evolutionary changes of rRNA genes and the translational machinery...
  6. pmc Evolution of cagA oncogene of Helicobacter pylori through recombination
    Yoshikazu Furuta
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Minato ku, Tokyo, Japan
    PLoS ONE 6:e23499. 2011
    ..Each showed a unique evolutionary distribution. These results clarify recombination-mediated routes of cagA evolution and provide a solid basis for a deeper understanding of its function in pathogenesis...
  7. pmc Cleavage of a model DNA replication fork by a methyl-specific endonuclease
    Ken Ishikawa
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Shirokanedai, Tokyo 108 8639, Japan
    Nucleic Acids Res 39:5489-98. 2011
    ..This process might serve to maintain an epigenetic status along the genome through programmed cell death...
  8. pmc Antisense RNA associated with biological regulation of a restriction-modification system
    Iwona Mruk
    Department of Microbiology, University of Gdansk, Kladki 24, Gdansk, 80 822, Poland
    Nucleic Acids Res 39:5622-32. 2011
    ..Taken together, these results strongly suggested the involvement of an antisense RNA in the biological regulation of this restriction-modification system...
  9. pmc Multiple genome comparison within a bacterial species reveals a unit of evolution spanning two adjacent genes in a tandem paralog cluster
    Takeshi Tsuru
    Laboratory of Social Genome Sciences, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan
    Mol Biol Evol 25:2457-73. 2008
    ..This work also illustrates the use of multiple genome sequences for high-resolution evolutionary analysis within the same species...
  10. pmc Discovery of a novel restriction endonuclease by genome comparison and application of a wheat-germ-based cell-free translation assay: PabI (5'-GTA/C) from the hyperthermophilic archaeon Pyrococcus abyssi
    Ken Ishikawa
    Department of Medical Genome Sciences, Graduate School of Frontier Science, University of Tokyo 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nucleic Acids Res 33:e112. 2005
    ..PabI is active up to 90 degrees C and optimally active at a pH of around 6 and in NaCl concentrations ranging from 100 to 200 mM. We predict that it has a novel 3D structure...
  11. pmc Domain movement within a gene: a novel evolutionary mechanism for protein diversification
    Yoshikazu Furuta
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Minato ku, Tokyo, Japan
    PLoS ONE 6:e18819. 2011
    ..Lateral domain movements within a protein, which we have designated DOMO (domain movement), represent novel routes for the diversification of proteins...
  12. pmc Genome comparison and context analysis reveals putative mobile forms of restriction-modification systems and related rearrangements
    Yoshikazu Furuta
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo 108 8639, Japan
    Nucleic Acids Res 38:2428-43. 2010
    ..This study revealed the possible mobility of all types of RM systems, and the diversity in their mobility-related organization...
  13. pmc Cleavage of a model DNA replication fork by a Type I restriction endonuclease
    Ken Ishikawa
    Graduate Program in Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 108 8639, Japan
    Nucleic Acids Res 37:3531-44. 2009
    ....
  14. pmc Methylome diversification through changes in DNA methyltransferase sequence specificity
    Yoshikazu Furuta
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Minato ku, Tokyo, Japan Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    PLoS Genet 10:e1004272. 2014
    ....
  15. pmc Conflicts targeting epigenetic systems and their resolution by cell death: novel concepts for methyl-specific and other restriction systems
    Ken Ishikawa
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    DNA Res 17:325-42. 2010
    ..These restriction systems clearly demonstrate the presence of conflicts between epigenetic systems...
  16. pmc Success of a suicidal defense strategy against infection in a structured habitat
    Masaki Fukuyo
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo 108 8639, Japan
    Sci Rep 2:238. 2012
    ..The infection results in emergence of pathogen mutants not inducing the host suicide in addition to host mutants resistant to the pathogen...
  17. pmc Novel protein fold discovered in the PabI family of restriction enzymes
    Ken Ichi Miyazono
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan
    Nucleic Acids Res 35:1908-18. 2007
    ..These results demonstrate the value of genome comparison and the wheat-germ-based system in finding a novel DNA-binding motif in mobile DNases and, in general, a novel protein fold in horizontally transferred genes...
  18. pmc Chromosome painting in silico in a bacterial species reveals fine population structure
    Koji Yahara
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan
    Mol Biol Evol 30:1454-64. 2013
    ..We expect this approach to further our understanding of intraspecific bacterial evolution by revealing population structure at a finer scale...
  19. pmc Cell death upon epigenetic genome methylation: a novel function of methyl-specific deoxyribonucleases
    Eri Fukuda
    Laboratory of Social Genome Sciences, Department of Medical Genome Sciences, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Genome Biol 9:R163. 2008
    ..A methyl-specific deoxyribonuclease, McrBC, of Escherichia coli cuts invading methylated DNAs. Here we examined whether McrBC competes with genome methylation systems through host killing by chromosome cleavage...
  20. pmc Type II restriction endonuclease R.Hpy188I belongs to the GIY-YIG nuclease superfamily, but exhibits an unusual active site
    Katarzyna H Kaminska
    Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4, 02 109 Warsaw, Poland
    BMC Struct Biol 8:48. 2008
    ....
  21. pmc Accumulation of large non-circular forms of the chromosome in recombination-defective mutants of Escherichia coli
    Naofumi Handa
    Division of Molecular Biology, Institute of Medical Science, University of Tokyo, Shirokanedai, Tokyo 108 8639 Japan
    BMC Mol Biol 4:5. 2003
    ..However, recent experiments suggest that such breakage may occur frequently during "normal" growth in various organisms - from bacteria through vertebrates, possibly through arrest of a replication fork at some endogenous DNA damage...
  22. pmc Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pylori East Asian genomes
    Mikihiko Kawai
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Minato ku, Tokyo, 108 8639, Japan
    BMC Microbiol 11:104. 2011
    ..We used newly developed comparative methods to follow the evolution of East Asian H. pylori genomes using 20 complete genome sequences from Japanese, Korean, Amerind, European, and West African strains...
  23. pmc CGAT: a comparative genome analysis tool for visualizing alignments in the analysis of complex evolutionary changes between closely related genomes
    Ikuo Uchiyama
    National Institute for Basic Biology, National Institutes of Natural Sciences, Nishigonaka 38, Myodaiji, Okazaki, Aichi 444 8585, Japan
    BMC Bioinformatics 7:472. 2006
    ....
  24. pmc Behavior of restriction-modification systems as selfish mobile elements and their impact on genome evolution
    I Kobayashi
    Department of Molecular Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nucleic Acids Res 29:3742-56. 2001
    ..The capacity of RM systems to act as selfish, mobile genetic elements may underlie the structure and function of RM enzymes...
  25. ncbi request reprint Shaping the genome--restriction-modification systems as mobile genetic elements
    I Kobayashi
    Institute of Medical Science, University of Tokyo, Shirokanedai, 108 8639, Japan
    Curr Opin Genet Dev 9:649-56. 1999
    ..A comparison of bacterial genomes supports the hypothesis that restriction-modification gene complexes are mobile elements involved in various genome rearrangements and evolution...
  26. ncbi request reprint Selfishness and death: raison d'être of restriction, recombination and mitochondria
    I Kobayashi
    Department of Molecular Biology, University of Tokyo, Japan
    Trends Genet 14:368-74. 1998
    ..By extrapolation, the capacity of mitochondria to kill their host eukaryotic cell might have stabilized their initial symbiosis...
  27. pmc DNA double-strand break repair: genetic determinants of flanking crossing-over
    K Kusano
    Department of Molecular Biology, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 91:1173-7. 1994
    ..We discuss how cooperation of the recQ gene product and the recJ gene product brings about double-strand break repair accompanied by flanking crossing-over. We also discuss how this reaction is related to repair of chromosome damages...
  28. ncbi request reprint Expression of Set-alpha during morphogenesis of mouse lower first molar
    H Yamaza
    Laboratory of Oral Pathology and Medicine, Faculty of Dental Science, Kyushu University 61, Fukuoka, Japan
    Histochem J 33:437-41. 2001
    ....
  29. ncbi request reprint Involvement of RecE exonuclease and RecT annealing protein in DNA double-strand break repair by homologous recombination
    K Kusano
    Department of Molecular Biology, University of Tokyo, Japan
    Gene 138:17-25. 1994
    ..From these observations, we conclude that both ExoVIII and RecT are essential for ds gap repair. We discuss their possible roles in the ds break repair reaction...
  30. ncbi request reprint Genotypic evolution in a quinolone-resistant Neisseria gonorrhoeae isolate from a patient with clinical failure of levofloxacin treatment
    M Tanaka
    Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Urol Int 62:64-8. 1999
    ..Our results indicate that levofloxacin selects a mutant having an additional alteration within the gene cording for the ParC protein during treatment, which may have enhanced quinolone resistance in the organism...
  31. pmc Orientation dependence in homologous recombination
    K Yamamoto
    Laboratory of Clinical Microbiology and Immunology, Bun in Hospital, Faculty of Medicine, University of Tokyo, Japan
    Genetics 143:27-36. 1996
    ..These results are consistent with our previous findings that the major route of recombination in recBC sbcBC strains generates only one recombinant DNA from two DNAs and in recBC sbcA strains generates two recombinant DNAs from two DNAs...
  32. ncbi request reprint Type V phosphodiesterase inhibition modulates endogenous immunoreactivities of endothelin-1 and endothelial nitric oxide synthase in pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension
    T Takahashi
    Department of Infectious Diseases and Applied Immunology, University of Tokyo, Japan
    Res Exp Med (Berl) 197:319-28. 1998
    ..Oral administration of E4021 modulates endogenous immunoreactivities of endothelin-1 and endothelial nitric oxide synthase with the improvement or right ventricular overload and medial thickening...
  33. ncbi request reprint Expression of p53 tumor suppressor gene in adenoid cystic and mucoepidermoid carcinomas of the salivary glands
    T Kiyoshima
    Department of Oral Pathology, Faculty of Dentistry, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan
    Oral Oncol 37:315-22. 2001
    ..The p53 immunopositivity in MEC correlated to the histological grade. The Ki-67 immunostaining ratio was also significantly related to the histological grade and the clinical course in MEC...
  34. ncbi request reprint Glycolytic enzyme Pgk1 is strongly expressed in the developing tooth germ of the mouse lower first molar
    J Y Honda
    Laboratory of Oral Pathology and Medicine, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
    Histol Histopathol 23:423-32. 2008
    ..These results suggested that Pgk1 plays some functional roles in the development of tooth germ and other embryonic organs by forming protein complex with GAPDH...
  35. pmc Susceptibilities of Neisseria gonorrhoeae isolates containing amino acid substitutions in GyrA, with or without substitutions in ParC, to newer fluoroquinolones and other antibiotics
    M Tanaka
    Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Antimicrob Agents Chemother 44:192-5. 2000
    ..Among the strains with various GyrA substitutions, strains with a serine-91-to-phenylalanine mutation required the highest MICs of all of the fluoroquinolones tested and were cross-resistant to structurally unrelated beta-lactams...
  36. ncbi request reprint Experimental genome evolution: large-scale genome rearrangements associated with resistance to replacement of a chromosomal restriction-modification gene complex
    N Handa
    Department of Molecular Biology, Institute of Medical Science, University of Tokyo, Shirokanedai, Tokyo 108-8639 Japan
    Mol Microbiol 40:932-40. 2001
    ..It was strongly suggested that multiple rounds of unequal IS3-IS3 recombination caused large-scale duplication and inversion of the chromosome, and that only one of the duplicated copies of the recipient PaeR7I was replaced...
  37. ncbi request reprint Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin
    K Hiramatsu
    Department of Bacteriology, Juntendo University, Tokyo, Japan
    Lancet 350:1670-3. 1997
    ..Two important questions need to be answered: (1) what is the prevalence of VRSA, and (2) by what mechanism does vancomycin resistance occur...
  38. ncbi request reprint Localization of activated caspase-3-positive and apoptotic cells in the developing tooth germ of the mouse lower first molar
    N Shigemura
    Laboratory of Oral Pathology and Medicine, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
    Histochem J 33:253-8. 2001
    ....
  39. ncbi request reprint Age-dependent changes in the distribution of BrdU- and TUNEL-positive cells in the murine gingival tissue
    T Sakai
    First Department of Prosthetic Dentistry, Faculty of Dentistry, Kyushu University, Fukuoka, Japan
    J Periodontol 70:973-81. 1999
    ..The purpose of this study was to investigate the age-dependent changes in the distribution of BrdU- and TUNEL-positive cells in murine gingival tissue...
  40. ncbi request reprint Immunohistochemical and ultrastructural study of a papillary cystadenocarcinoma arising from the sublingual gland
    I Kobayashi
    Department of Oral Pathology, Faculty of Dentistry, Kyushu University, Fukuoka, Japan
    J Oral Pathol Med 28:282-6. 1999
    ..However, the biological role of these carbohydrate antigens in salivary gland tumors is unclear at present. Further investigations are, therefore, called for to solve this issue...
  41. ncbi request reprint Gene conversion in the Escherichia coli RecF pathway: a successive half crossing-over model
    K Yamamoto
    Department of Bacteriology, Medical School, University of Tokyo, Japan
    Mol Gen Genet 234:1-13. 1992
    ....
  42. ncbi request reprint Whole genome sequencing of meticillin-resistant Staphylococcus aureus
    M Kuroda
    Hiramatsu, Department of Bacteriology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan
    Lancet 357:1225-40. 2001
    ..Investigation of many newly identified gene products, including the 70 putative virulence factors, will greatly improve our understanding of the biology of staphylococci and the processes of infectious diseases caused by S aureus...
  43. pmc A preliminary study to determine the diagnostic reference level using dose-area product for limited-area cone beam CT
    A Endo
    Department of Radiology, Showa University School of Dentistry, Tokyo, Japan
    Dentomaxillofac Radiol 42:20120097. 2013
    ....
  44. ncbi request reprint In situ expression of RANKL, RANK, osteoprotegerin and cytokines in osteoclasts of rat periodontal tissue
    T Ogasawara
    Department of Operative Dentistry and Endodontology, Kyushu University, Fukuoka, Japan
    J Periodontal Res 39:42-9. 2004
    ....
  45. ncbi request reprint Development of systemic bacteraemia after oral inoculation of vancomycin-resistant enterococci in mice
    S Miyazaki
    Department of Microbiology, Toho University School of Medicine, Tokyo, Japan
    J Med Microbiol 50:695-701. 2001
    ..E. coli may be intimately associated with the establishment of VRE translocation...
  46. ncbi request reprint Ionic binding of 3H-gentamicin and short-time bactericidal activity of gentamicin against Pseudomonas aeruginosa isolates with different lipopolysaccharide structures
    T Saika
    Chemotherapy Division, Mitsubishi Kagaku Bio Clinical Laboratories, Inc, Tokyo, Japan
    Chemotherapy 45:296-302. 1999
    ..This manner of binding may be also applied to P. aeruginosa No. 45 (LPS-deficient), a clinical isolate...
  47. ncbi request reprint Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland
    K Okamura
    Department of Oral Pathology, Fukuoka Dental College, 2 15 1 Tamura, Sawara ku, 814 0193, Fukuoka, Japan
    Oral Oncol 38:244-50. 2002
    ..These results suggest that the immunostaining for CA19-9 and CA125 provide no reliable data to predict the clinical course of patients with MEC and ACC of the salivary glands...
  48. ncbi request reprint Endothelin converting enzyme inhibitor protects development of right ventricular overload and medial thickening of pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension
    T Takahashi
    Department of Infectious Diseases, Institute of Medical Science, University of Tokyo, Japan
    Life Sci 63:PL137-43. 1998
    ..FR901533 (100 mg/kg/day), protected the development of right ventricular overload and medial thickening of pulmonary arteries in a rat model of pulmonary hypertension...
  49. pmc Antimicrobial susceptibilities of Helicobacter pylori isolates under microaerophilic atmospheres established by two different methods
    I Kobayashi
    Chemotherapy Division, Mitsubishi Kagaku Bio Clinical Laboratories, Inc, Tokyo, Japan
    J Clin Microbiol 39:2646-7. 2001
    ..The MICs of clarithromycin, amoxicillin, and metronidazole determined under both microaerophilic atmospheres were mostly within one twofold dilution for 146 (97.3%), 150 (100%), and 149 (99.3%) of the isolates, respectively...
  50. ncbi request reprint Detection of differentially expressed genes in the early developmental stage of the mouse mandible
    H Yamaza
    Department of Oral Pathology, Faculty of Dentistry, Kyushu University, Fukuoka, Japan
    Int J Dev Biol 45:675-80. 2001
    ....
  51. pmc Characterization of optically stimulated luminescence dosemeters to measure organ doses in diagnostic radiology
    A Endo
    Department of Radiology, Showa University Dental Hospital, Ota ku, Tokyo, Japan
    Dentomaxillofac Radiol 41:211-6. 2012
    ..The aim of this study was to assess the characteristics of an optically stimulated luminescence dosemeter (OSLD) for use in diagnostic radiology and to apply the OSLD in measuring the organ doses by panoramic radiography...
  52. ncbi request reprint Antimicrobial activity of gemifloxacin (SB-265805), a newer fluoroquinolone, against clinical isolates of Neisseria gonorrhoeae, including fluoroquinolone-resistant isolates
    M Tanaka
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diagn Microbiol Infect Dis 38:109-13. 2000
    ..Moreover, the activity of gemifloxacin against fluoroquinolone-resistant gonococcal isolates containing multiple amino acid substitutions in both GyrA and ParC proteins was superior to those of the other compounds...
  53. ncbi request reprint A novel, 11 nucleotide variant of chi, chi*: one of a class of sequences defining the Escherichia coli recombination hotspot chi
    D A Arnold
    Sections of Microbiology and of Molecular and Cellular Biology, University of California at Davis, CA 95616, USA
    J Mol Biol 300:469-79. 2000
    ....
  54. ncbi request reprint A defect in harmonin, a PDZ domain-containing protein expressed in the inner ear sensory hair cells, underlies Usher syndrome type 1C
    E Verpy
    Unité de Génétique des Déficits Sensoriels, CNRS URA 1968, Institut Pasteur, Paris Cedex 15, France
    Nat Genet 26:51-5. 2000
    ..As several of these transcripts were absent from the eye, we propose that USH1C also underlies the DFNB18 form of isolated deafness...
  55. ncbi request reprint Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance
    K Takeda
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Hum Mol Genet 9:125-32. 2000
    ..These findings suggest that the Ser298 is important for MITF function and is phosphorylated probably by GSK3beta...
  56. ncbi request reprint [Study of diarrhea-inducing strains of Escherichia coli mainly isolated in Kanto area between June and September 1996]
    I Kobayashi
    Department of Clinical Microbiology, Mitsubishi Kagaku Bio Clinical Laboratory, Inc
    Kansenshogaku Zasshi 71:495-500. 1997
    ..coli O157 tested were susceptible to all antibiotics such as ampicillin, doxycylin, levofloxacin, fosfomycin, chloramphenicol and polymyxin B, and no strains resistant to levofloxacin, polymyxin B and fosfomycin were found...