N Kinae

Summary

Affiliation: University of Shizuoka
Country: Japan

Publications

  1. ncbi request reprint Functional properties of wasabi and horseradish
    N Kinae
    School of Food and Nutritional Sciences, University of Shizuoka, Japan
    Biofactors 13:265-9. 2000
  2. ncbi request reprint Food and health longevity
    Naohide Kinae
    School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka City, Japan
    Yakugaku Zasshi 127:399-406. 2007
  3. ncbi request reprint Formation of mutagenic/carcinogenic heterocyclic amines under moderate conditions
    Naohide Kinae
    Laboratory of Food Hygiene and COE Program in the 21st Century, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, 422 8526, Japan
    Ann N Y Acad Sci 1043:80-4. 2005
  4. ncbi request reprint Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans
    K Shimoi
    School of Food and Nutritional Sciences, University of Shizuoka, Japan
    FEBS Lett 438:220-4. 1998
  5. ncbi request reprint Metabolic fate of luteolin and its functional activity at focal site
    K Shimoi
    School of Food and Nutritional Sciences and Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Japan
    Biofactors 12:181-6. 2000
  6. ncbi request reprint Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammation
    K Shimoi
    Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Drug Metab Dispos 29:1521-4. 2001
  7. ncbi request reprint A novel mutagen, 2-(5-hydroxy-4,6-dinitroindolyl) ethanol, formed in the reaction between 5-hydroxytryptamine and nitrite under acid conditions, especially in the presence of L-cysteine
    Shuichi Masuda
    Graduate School of Nutritional and Environmental Sciences and 21st COE Program, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Mutat Res 588:172-6. 2005
  8. ncbi request reprint Changes in the mutagenic and estrogenic activities of 17beta-estradiol after treatment with nitrite
    Shuichi Masuda
    Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Biosci Biotechnol Biochem 70:890-6. 2006
  9. ncbi request reprint Changes in the mutagenic and estrogenic activities of bisphenol A upon treatment with nitrite
    Shuichi Masuda
    Graduate School of Nutritional and Environmental Sciences, COE Program in the 21st Century, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Mutat Res 585:137-46. 2005
  10. ncbi request reprint Genotoxicity of 2-[2-(acetylamino)-4-[bis(2-hydroxyethyl)amino]-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-6) and 4-amino-3,3'-dichloro-5,4'-dinitro-biphenyl (ADDB) in goldfish (Carassius auratus) using the micronucleus test and the
    Shuichi Masuda
    Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Mutat Res 560:33-40. 2004

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Functional properties of wasabi and horseradish
    N Kinae
    School of Food and Nutritional Sciences, University of Shizuoka, Japan
    Biofactors 13:265-9. 2000
    ..Three components including (-)-(R)-7-methylsulfinylheptyl isothiocyanate were identified. These data show that wasabi and horseradish might be potent functional foods for keeping human health...
  2. ncbi request reprint Food and health longevity
    Naohide Kinae
    School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka City, Japan
    Yakugaku Zasshi 127:399-406. 2007
    ..Safety evaluation methods will be developed for the combined use, thus establishing a novel academic field for human health sciences. We call this "borderless sciences of food and medicine" (yaku-shoku dogen)...
  3. ncbi request reprint Formation of mutagenic/carcinogenic heterocyclic amines under moderate conditions
    Naohide Kinae
    Laboratory of Food Hygiene and COE Program in the 21st Century, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, 422 8526, Japan
    Ann N Y Acad Sci 1043:80-4. 2005
    ..It is said that the heating process is an essential factor in the formation of HCAs. But our experiment shows that HCAs are produced not only in the cooking process, but also in moderate conditions such as 37 degrees C and 50 degrees C...
  4. ncbi request reprint Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans
    K Shimoi
    School of Food and Nutritional Sciences, University of Shizuoka, Japan
    FEBS Lett 438:220-4. 1998
    ..HPLC analysis also allowed us to demonstrate the presence of free luteolin and its monoglucuronide in human serum after ingestion of luteolin...
  5. ncbi request reprint Metabolic fate of luteolin and its functional activity at focal site
    K Shimoi
    School of Food and Nutritional Sciences and Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Japan
    Biofactors 12:181-6. 2000
    ..These results suggest the posssibility that deconjugation of luteolin monoglucuronide occurs and that free luteolin showed functional acyivities such as suppression of TNF-alpha induced ICAM- 1 expression at inflammation site...
  6. ncbi request reprint Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammation
    K Shimoi
    Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Drug Metab Dispos 29:1521-4. 2001
    ..These results suggest that during inflammation beta-glucuronidase is released from stimulated neutrophils or certain injured cells and then deglucuronidation of flavonoids occurs...
  7. ncbi request reprint A novel mutagen, 2-(5-hydroxy-4,6-dinitroindolyl) ethanol, formed in the reaction between 5-hydroxytryptamine and nitrite under acid conditions, especially in the presence of L-cysteine
    Shuichi Masuda
    Graduate School of Nutritional and Environmental Sciences and 21st COE Program, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Mutat Res 588:172-6. 2005
    ..Our results suggest that 2HDIE might be formed in vivo by consumption of 5-HT, nitrite and L-cysteine in foods, and might act as a mutagen...
  8. ncbi request reprint Changes in the mutagenic and estrogenic activities of 17beta-estradiol after treatment with nitrite
    Shuichi Masuda
    Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Biosci Biotechnol Biochem 70:890-6. 2006
    ..These data suggest that a daily oral intake of 17beta-estradiol and nitrite might induce the formation of mutagenic compounds in our body...
  9. ncbi request reprint Changes in the mutagenic and estrogenic activities of bisphenol A upon treatment with nitrite
    Shuichi Masuda
    Graduate School of Nutritional and Environmental Sciences, COE Program in the 21st Century, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Mutat Res 585:137-46. 2005
    ....
  10. ncbi request reprint Genotoxicity of 2-[2-(acetylamino)-4-[bis(2-hydroxyethyl)amino]-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-6) and 4-amino-3,3'-dichloro-5,4'-dinitro-biphenyl (ADDB) in goldfish (Carassius auratus) using the micronucleus test and the
    Shuichi Masuda
    Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Mutat Res 560:33-40. 2004
    ..p. injection of ADDB and persisted for up to 6h. These results show that both PBTA-6 and ADDB have genotoxic effects in goldfish...
  11. ncbi request reprint Evaluation of mutagenic activities of leachates in landfill sites by micronucleus test and comet assay using goldfish
    Yuya Deguchi
    Graduate School of Nutritional and Environmental Sciences and COE Program in the 21st Century, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Mutat Res 627:178-85. 2007
    ..A combination of the two bioassays was shown to be useful to evaluate the mutagenic activity of the leachates. We also propose a new scoring method for determination of water quality by using acute toxicity and mutagenic activity...
  12. ncbi request reprint Comparison between high-performance liquid chromatography and enzyme-linked immunosorbent assay for the determination of 8-hydroxy-2'-deoxyguanosine in human urine
    Kayoko Shimoi
    Institute for Environmental Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422 8526
    Cancer Epidemiol Biomarkers Prev 11:767-70. 2002
    ..It is suggested that the ELISA system is applicable for comparative human monitoring studies. Prepurification of 'samples is required to determine the absolute value of 8-OH-dG in individual urine samples by ELISA...
  13. ncbi request reprint Isolation of mutagenic beta-carboline derivatives after nitrite treatment of maillard reaction mixtures and analysis of these compounds from foodstuffs and human urine
    Shuichi Masuda
    Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and COE Program in the 21st Century, University of Shizuoka, Japan
    Biosci Biotechnol Biochem 69:2232-5. 2005
    ..0. Four beta-carboline derivatives were isolated as premutagens from mixtures of methylglyoxal and furfural. These premutagens were also found to be contained in daily foodstuffs and human urine samples...
  14. ncbi request reprint Genotoxicity and estrogenic activity of 3,3'-dinitrobisphenol A in goldfish
    Tomoyasu Toyoizumi
    Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and COE Program in the 21st Century, University of Shizuoka, Japan
    Biosci Biotechnol Biochem 72:2118-23. 2008
    ..On the other hand, BPA did not significantly increase the frequency of micronucleated cells. In conclusion, we found that dinitro-BPA did not show estrogenic activity, but had genotoxic potency stronger than that of BPA...
  15. doi request reprint Induction effect of coadministration of soybean isoflavones and sodium nitrite on DNA damage in mouse stomach
    Tomoyasu Toyoizumi
    Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Food Chem Toxicol 48:2585-91. 2010
    ..However, the induction of inflammation in the stomach was not found. These data suggest that coadministration of isoflavones and NaNO(2) can cause DNA damage in the stomach because of the formation of radicals...
  16. doi request reprint Application of a new bioassay technique using goldfish for assessment of water toxicity
    Yuya Deguchi
    Graduate School of Nutritional and Environmental Sciences, COE Program in the 21st Century, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Environ Toxicol 23:720-7. 2008
    ..We could evaluate both genotoxicity and estrogenic activity simultaneously, so goldfish might be a good experimental model for estimation of chemical contamination levels in aquatic environment...
  17. ncbi request reprint Oxidative DNA damage induced by high glucose and its suppression in human umbilical vein endothelial cells
    K Shimoi
    Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Mutat Res 480:371-8. 2001
    ..The results shown in this study suggest that glyoxal formed intracellularly or extracellularly during high glucose treatment might induce FPG-sensitive sites by a mechanism not involving reactive oxygen species...
  18. ncbi request reprint Leaf extract of Wasabia japonica relieved oxidative stress induced by Helicobacter pylori infection and stress loading in Mongolian gerbils
    Hirotaka Sekiguchi
    Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences, and Global COE Program, University of Shizuoka, Shizuoka, Japan
    Biosci Biotechnol Biochem 74:1194-9. 2010
    ..pylori infection and physical stress loading might induce oxidative DNA damage additively, while a leaf extract attenuated this DNA damage in the stomach as well as the peripheral erythrocytes...
  19. doi request reprint Functional analyses of neutrophil-like differentiated cell lines under a hyperglycemic condition
    Tomoko Oya-Ito
    Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Mol Nutr Food Res 52:360-9. 2008
    ..These extraordinary sensitivities caused by the higher glucose treatments may reflect the dysfunction or overactivation of neutrophils...
  20. ncbi request reprint Identification of 6-methylsulfinylhexyl isothiocyanate as an apoptosis-inducing component in wasabi
    Makoto Watanabe
    School of Food and Nutritional Sciences, University of Shizuoka, and Centre of Excellence for Evolutionary Human Health Sciences, Yada 52 1, Shizuoka 422 8526, Japan
    Phytochemistry 62:733-9. 2003
    ..Several lines of evidence indicated that 6-HITC induced apoptosis in U937 cells and human stomach cancer MKN45 cells. Thus, 6-HITC is potentially useful as a natural anti-cancer agent...
  21. ncbi request reprint Genotoxicity of acrylamide and glycidamide in human lymphoblastoid TK6 cells
    Naoki Koyama
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Mutat Res 603:151-8. 2006
    ..The cytotoxicity and genotoxicity of AA were not enhanced by metabolic activation (rat liver S9), implying that the rat liver S9 did not activate AA. We discuss the in vitro and in vivo genotoxicity of AA and GA...
  22. ncbi request reprint MX, a by-product of water chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional intercellular communication in rat WB cells
    Akiyoshi Nishikawa
    Division of Pathology, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Environ Mol Mutagen 47:48-55. 2006
    ..These findings indicate that MX is not mutagenic, mitogenic or carcinogenic in mice, and suggest that the compound exerts epigenetic actions leading to GJIC inhibition...
  23. ncbi request reprint Peroxynitrite induces formation of N( epsilon )-(carboxymethyl) lysine by the cleavage of Amadori product and generation of glucosone and glyoxal from glucose: novel pathways for protein modification by peroxynitrite
    Ryoji Nagai
    Department of Biochemistry, Kumamoto University School of Medicine, Kumamoto, Japan
    Diabetes 51:2833-9. 2002
    ..Our results provide the first evidence that ONOO(-) can induce protein modification by oxidative cleavage of the Amadori product and also by generation of reactive alpha-oxoaldehydes from glucose...
  24. ncbi request reprint 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone [MX] shows initiating and promoting activities in a two-stage BALB/c 3T3 cell transformation assay
    Madoka Nakajima
    Genetic Toxicology Group, Biosafety Research Center, Foods, Drugs and Pesticides, 582 2, Shioshinden, Iwata gun Shizuoka 437 1213, Japan
    Mutagenesis 20:375-9. 2005
    ..This in vitro cell transformation study with MX adds supportive information to studies showing MX carcinogenicity and tumour promoter activity, and adds mechanistic understanding of the action of MX...