Research Topics
| N KinaeSummaryAffiliation: University of Shizuoka Country: Japan Publications
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Detail Information
Publications
Functional properties of wasabi and horseradishN Kinae
School of Food and Nutritional Sciences, University of Shizuoka, Japan
Biofactors 13:265-9. 2000..Three components including (-)-(R)-7-methylsulfinylheptyl isothiocyanate were identified. These data show that wasabi and horseradish might be potent functional foods for keeping human health...- Food and health longevityNaohide Kinae
School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka City, Japan
Yakugaku Zasshi 127:399-406. 2007..Safety evaluation methods will be developed for the combined use, thus establishing a novel academic field for human health sciences. We call this "borderless sciences of food and medicine" (yaku-shoku dogen)... - Formation of mutagenic/carcinogenic heterocyclic amines under moderate conditionsNaohide Kinae
Laboratory of Food Hygiene and COE Program in the 21st Century, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, 422 8526, Japan
Ann N Y Acad Sci 1043:80-4. 2005..It is said that the heating process is an essential factor in the formation of HCAs. But our experiment shows that HCAs are produced not only in the cooking process, but also in moderate conditions such as 37 degrees C and 50 degrees C... - Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humansK Shimoi
School of Food and Nutritional Sciences, University of Shizuoka, Japan
FEBS Lett 438:220-4. 1998..HPLC analysis also allowed us to demonstrate the presence of free luteolin and its monoglucuronide in human serum after ingestion of luteolin... - Metabolic fate of luteolin and its functional activity at focal siteK Shimoi
School of Food and Nutritional Sciences and Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Japan
Biofactors 12:181-6. 2000..These results suggest the posssibility that deconjugation of luteolin monoglucuronide occurs and that free luteolin showed functional acyivities such as suppression of TNF-alpha induced ICAM- 1 expression at inflammation site... - Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammationK Shimoi
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
Drug Metab Dispos 29:1521-4. 2001..These results suggest that during inflammation beta-glucuronidase is released from stimulated neutrophils or certain injured cells and then deglucuronidation of flavonoids occurs... - A novel mutagen, 2-(5-hydroxy-4,6-dinitroindolyl) ethanol, formed in the reaction between 5-hydroxytryptamine and nitrite under acid conditions, especially in the presence of L-cysteineShuichi Masuda
Graduate School of Nutritional and Environmental Sciences and 21st COE Program, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
Mutat Res 588:172-6. 2005..Our results suggest that 2HDIE might be formed in vivo by consumption of 5-HT, nitrite and L-cysteine in foods, and might act as a mutagen... - Changes in the mutagenic and estrogenic activities of 17beta-estradiol after treatment with nitriteShuichi Masuda
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
Biosci Biotechnol Biochem 70:890-6. 2006..These data suggest that a daily oral intake of 17beta-estradiol and nitrite might induce the formation of mutagenic compounds in our body... - Changes in the mutagenic and estrogenic activities of bisphenol A upon treatment with nitriteShuichi Masuda
Graduate School of Nutritional and Environmental Sciences, COE Program in the 21st Century, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
Mutat Res 585:137-46. 2005.... - Genotoxicity of 2-[2-(acetylamino)-4-[bis(2-hydroxyethyl)amino]-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-6) and 4-amino-3,3'-dichloro-5,4'-dinitro-biphenyl (ADDB) in goldfish (Carassius auratus) using the micronucleus test and the Shuichi Masuda
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
Mutat Res 560:33-40. 2004..p. injection of ADDB and persisted for up to 6h. These results show that both PBTA-6 and ADDB have genotoxic effects in goldfish... - Evaluation of mutagenic activities of leachates in landfill sites by micronucleus test and comet assay using goldfishYuya Deguchi
Graduate School of Nutritional and Environmental Sciences and COE Program in the 21st Century, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
Mutat Res 627:178-85. 2007..A combination of the two bioassays was shown to be useful to evaluate the mutagenic activity of the leachates. We also propose a new scoring method for determination of water quality by using acute toxicity and mutagenic activity... - Comparison between high-performance liquid chromatography and enzyme-linked immunosorbent assay for the determination of 8-hydroxy-2'-deoxyguanosine in human urineKayoko Shimoi
Institute for Environmental Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422 8526
Cancer Epidemiol Biomarkers Prev 11:767-70. 2002..It is suggested that the ELISA system is applicable for comparative human monitoring studies. Prepurification of 'samples is required to determine the absolute value of 8-OH-dG in individual urine samples by ELISA... - Isolation of mutagenic beta-carboline derivatives after nitrite treatment of maillard reaction mixtures and analysis of these compounds from foodstuffs and human urineShuichi Masuda
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and COE Program in the 21st Century, University of Shizuoka, Japan
Biosci Biotechnol Biochem 69:2232-5. 2005..0. Four beta-carboline derivatives were isolated as premutagens from mixtures of methylglyoxal and furfural. These premutagens were also found to be contained in daily foodstuffs and human urine samples... - Genotoxicity and estrogenic activity of 3,3'-dinitrobisphenol A in goldfishTomoyasu Toyoizumi
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and COE Program in the 21st Century, University of Shizuoka, Japan
Biosci Biotechnol Biochem 72:2118-23. 2008..On the other hand, BPA did not significantly increase the frequency of micronucleated cells. In conclusion, we found that dinitro-BPA did not show estrogenic activity, but had genotoxic potency stronger than that of BPA... 
Induction effect of coadministration of soybean isoflavones and sodium nitrite on DNA damage in mouse stomachTomoyasu Toyoizumi
Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
Food Chem Toxicol 48:2585-91. 2010..However, the induction of inflammation in the stomach was not found. These data suggest that coadministration of isoflavones and NaNO(2) can cause DNA damage in the stomach because of the formation of radicals...- Application of a new bioassay technique using goldfish for assessment of water toxicityYuya Deguchi
Graduate School of Nutritional and Environmental Sciences, COE Program in the 21st Century, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
Environ Toxicol 23:720-7. 2008..We could evaluate both genotoxicity and estrogenic activity simultaneously, so goldfish might be a good experimental model for estimation of chemical contamination levels in aquatic environment... - Oxidative DNA damage induced by high glucose and its suppression in human umbilical vein endothelial cellsK Shimoi
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
Mutat Res 480:371-8. 2001..The results shown in this study suggest that glyoxal formed intracellularly or extracellularly during high glucose treatment might induce FPG-sensitive sites by a mechanism not involving reactive oxygen species... - Leaf extract of Wasabia japonica relieved oxidative stress induced by Helicobacter pylori infection and stress loading in Mongolian gerbilsHirotaka Sekiguchi
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences, and Global COE Program, University of Shizuoka, Shizuoka, Japan
Biosci Biotechnol Biochem 74:1194-9. 2010..pylori infection and physical stress loading might induce oxidative DNA damage additively, while a leaf extract attenuated this DNA damage in the stomach as well as the peripheral erythrocytes... - Functional analyses of neutrophil-like differentiated cell lines under a hyperglycemic conditionTomoko Oya-Ito
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
Mol Nutr Food Res 52:360-9. 2008..These extraordinary sensitivities caused by the higher glucose treatments may reflect the dysfunction or overactivation of neutrophils... - Identification of 6-methylsulfinylhexyl isothiocyanate as an apoptosis-inducing component in wasabiMakoto Watanabe
School of Food and Nutritional Sciences, University of Shizuoka, and Centre of Excellence for Evolutionary Human Health Sciences, Yada 52 1, Shizuoka 422 8526, Japan
Phytochemistry 62:733-9. 2003..Several lines of evidence indicated that 6-HITC induced apoptosis in U937 cells and human stomach cancer MKN45 cells. Thus, 6-HITC is potentially useful as a natural anti-cancer agent... - Genotoxicity of acrylamide and glycidamide in human lymphoblastoid TK6 cellsNaoki Koyama
Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
Mutat Res 603:151-8. 2006..The cytotoxicity and genotoxicity of AA were not enhanced by metabolic activation (rat liver S9), implying that the rat liver S9 did not activate AA. We discuss the in vitro and in vivo genotoxicity of AA and GA... - MX, a by-product of water chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional intercellular communication in rat WB cellsAkiyoshi Nishikawa
Division of Pathology, National Institute of Health Sciences, Tokyo 158 8501, Japan
Environ Mol Mutagen 47:48-55. 2006..These findings indicate that MX is not mutagenic, mitogenic or carcinogenic in mice, and suggest that the compound exerts epigenetic actions leading to GJIC inhibition... - Peroxynitrite induces formation of N( epsilon )-(carboxymethyl) lysine by the cleavage of Amadori product and generation of glucosone and glyoxal from glucose: novel pathways for protein modification by peroxynitriteRyoji Nagai
Department of Biochemistry, Kumamoto University School of Medicine, Kumamoto, Japan
Diabetes 51:2833-9. 2002..Our results provide the first evidence that ONOO(-) can induce protein modification by oxidative cleavage of the Amadori product and also by generation of reactive alpha-oxoaldehydes from glucose... - 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone [MX] shows initiating and promoting activities in a two-stage BALB/c 3T3 cell transformation assayMadoka Nakajima
Genetic Toxicology Group, Biosafety Research Center, Foods, Drugs and Pesticides, 582 2, Shioshinden, Iwata gun Shizuoka 437 1213, Japan
Mutagenesis 20:375-9. 2005..This in vitro cell transformation study with MX adds supportive information to studies showing MX carcinogenicity and tumour promoter activity, and adds mechanistic understanding of the action of MX...