H Kimura

Summary

Affiliation: University of Fukui
Country: Japan

Publications

  1. ncbi request reprint A cholesteryl ester transfer protein gene mutation and vascular disease in dialysis patients
    H Kimura
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, Fukui Medical University, Yoshida, Japan
    J Am Soc Nephrol 10:294-9. 1999
  2. ncbi request reprint A common mutation of cholesteryl ester transfer protein gene in dialysis patients
    H Kimura
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, Fukui Medical University, Japan
    Kidney Int Suppl 71:S186-9. 1999
  3. ncbi request reprint Lipid-binding proteins in rat and human kidney
    H Kimura
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, Fukui Medical University, Japan
    Kidney Int Suppl 71:S159-62. 1999
  4. ncbi request reprint Polymorphisms of angiotensin converting enzyme and plasminogen activator inhibitor-1 genes in diabetes and macroangiopathy1
    H Kimura
    Department of Medicine II, Niigata University School of Medicine, Niigata, Japan
    Kidney Int 54:1659-69. 1998
  5. ncbi request reprint The C677T methylenetetrahydrofolate reductase gene mutation in hemodialysis patients
    H Kimura
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, Fukui Medical University, Fukui, Japan
    J Am Soc Nephrol 11:885-93. 2000
  6. ncbi request reprint Apolipoprotein E4 reduces risk of diabetic nephropathy in patients with NIDDM
    H Kimura
    Department of Medicine II, Nigata University School of Medicine, Japan
    Am J Kidney Dis 31:666-73. 1998
  7. ncbi request reprint Cholesteryl ester transfer protein as a protective factor against vascular disease in hemodialysis patients
    H Kimura
    Department of Clinical Laboratory Medicine and Nephrology, Fukui Medical University, Japan
    Am J Kidney Dis 38:70-6. 2001
  8. ncbi request reprint Hepatic lipase mutation may reduce vascular disease prevalence in hemodialysis patients with high CETP levels
    Hideki Kimura
    Department of Clinical Laboratory Medicine and Nephrology, Faculty of Medicine, Fukui Medical University, Fukui, Japan
    Kidney Int 64:1829-37. 2003
  9. ncbi request reprint Thalamic abnormalities in patients with schizophrenia revealed by proton magnetic resonance spectroscopy
    M Omori
    Department of Neuropsychiatry, Fukui Medical University, Matsuoka, 910 1193, Fukui, Japan
    Psychiatry Res 98:155-62. 2000
  10. ncbi request reprint A C677T mutation in the methylenetetrahydrofolate reductase gene modifies serum cysteine in dialysis patients
    H Kimura
    Department of Clinical Laboratory Medicine and Nephrology, Faculty of Medicine, Fukui Medical University, Niigata, Japan
    Am J Kidney Dis 36:925-33. 2000

Collaborators

Detail Information

Publications85

  1. ncbi request reprint A cholesteryl ester transfer protein gene mutation and vascular disease in dialysis patients
    H Kimura
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, Fukui Medical University, Yoshida, Japan
    J Am Soc Nephrol 10:294-9. 1999
    ..9 (95% confidence interval, 1.05 to 22.65; P < 0.05). In conclusion, the D442G mutation is an independent risk factor for atherosclerotic complications in dialysis patients with HDL-C levels below 45 mg/dl...
  2. ncbi request reprint A common mutation of cholesteryl ester transfer protein gene in dialysis patients
    H Kimura
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, Fukui Medical University, Japan
    Kidney Int Suppl 71:S186-9. 1999
    ..A common missense mutation of cholesteryl ester transfer protein (CETP) gene, D442G (Asp442 to Gly), increases HDL-C levels, but the mutation may also diminish the activity of reverse cholesterol transport...
  3. ncbi request reprint Lipid-binding proteins in rat and human kidney
    H Kimura
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, Fukui Medical University, Japan
    Kidney Int Suppl 71:S159-62. 1999
    ....
  4. ncbi request reprint Polymorphisms of angiotensin converting enzyme and plasminogen activator inhibitor-1 genes in diabetes and macroangiopathy1
    H Kimura
    Department of Medicine II, Niigata University School of Medicine, Niigata, Japan
    Kidney Int 54:1659-69. 1998
    ..Therefore, ACE and PAI-1 polymorphisms may have a synergistic effect on diabetic nephropathy and macroangiopathy...
  5. ncbi request reprint The C677T methylenetetrahydrofolate reductase gene mutation in hemodialysis patients
    H Kimura
    Department of Clinical and Laboratory Medicine, Faculty of Medicine, Fukui Medical University, Fukui, Japan
    J Am Soc Nephrol 11:885-93. 2000
    ..These results indicate that the methylenetetrahydrofolate reductase mutation is a significant independent predictor for serum total homocysteine concentration...
  6. ncbi request reprint Apolipoprotein E4 reduces risk of diabetic nephropathy in patients with NIDDM
    H Kimura
    Department of Medicine II, Nigata University School of Medicine, Japan
    Am J Kidney Dis 31:666-73. 1998
    ..Results indicate that apolipoprotein E polymorphism is associated with the progression of diabetic nephropathy. Presence of the apolipoprotein E4 allele is a protective factor, and other alleles are risk factors...
  7. ncbi request reprint Cholesteryl ester transfer protein as a protective factor against vascular disease in hemodialysis patients
    H Kimura
    Department of Clinical Laboratory Medicine and Nephrology, Fukui Medical University, Japan
    Am J Kidney Dis 38:70-6. 2001
    ..1 to 0.97; P < 0.05) after adjusting for age. These results suggest that CETP may serve as a protective factor against vascular disease in hemodialysis patients, especially those with normal or elevated HDL-C concentrations...
  8. ncbi request reprint Hepatic lipase mutation may reduce vascular disease prevalence in hemodialysis patients with high CETP levels
    Hideki Kimura
    Department of Clinical Laboratory Medicine and Nephrology, Faculty of Medicine, Fukui Medical University, Fukui, Japan
    Kidney Int 64:1829-37. 2003
    ..However, whether the HL mutation is antiatherogenic or proatherogenic has remained unknown in uremic patients and the general population...
  9. ncbi request reprint Thalamic abnormalities in patients with schizophrenia revealed by proton magnetic resonance spectroscopy
    M Omori
    Department of Neuropsychiatry, Fukui Medical University, Matsuoka, 910 1193, Fukui, Japan
    Psychiatry Res 98:155-62. 2000
    ....
  10. ncbi request reprint A C677T mutation in the methylenetetrahydrofolate reductase gene modifies serum cysteine in dialysis patients
    H Kimura
    Department of Clinical Laboratory Medicine and Nephrology, Faculty of Medicine, Fukui Medical University, Niigata, Japan
    Am J Kidney Dis 36:925-33. 2000
    ..The tCys-increasing effect of folate and vitamin B(12) appears to be linked to their enhancement of Hcy remethylation...
  11. ncbi request reprint Kidney fatty acid-binding protein: identification as alpha 2U-globulin
    H Kimura
    Department of Biochemistry, Niigata University School of Medicine, Japan
    FEBS Lett 246:101-4. 1989
    ..This fatty acid-binding protein could not be immunologically detected in female rat kidney...
  12. ncbi request reprint Vascular permeability: quantitative measurement with double-echo dynamic MR imaging--theory and clinical application
    H Uematsu
    Department of Radiology, Fukui Medical University, Yoshida gun, Japan
    Radiology 214:912-7. 2000
    ..Meningioma was characterized on the basis of higher vascularity and neurinoma on the basis of higher permeability. The proposed method enables better tissue characterization...
  13. ncbi request reprint Purification and characterization of a fatty-acid-binding protein from the gastric mucosa of rats. Possible identity with heart fatty-acid-binding protein and its parietal cell localization
    T Kanda
    Department of Biochemistry, Niigata University School of Medicine, Japan
    Eur J Biochem 185:27-33. 1989
    ..The results suggested that the primary structure of stomach FABP is identical with that of rat heart FABP, and showed that stomach FABP is localized in parietal cells of the gastric mucosa...
  14. ncbi request reprint Effects of a novel elastase inhibitor, ONO-5046, on nephrotoxic serum nephritis in rats
    S Suzuki
    Department of Clinical and Laboratory Medicine, Fukui Medical University, Japan
    Kidney Int 53:1201-8. 1998
    ....
  15. pmc Rat heart fatty acid-binding protein. Evidence that supports the amino acid sequence predicted from the cDNA
    H Kimura
    Department of Biochemistry, Niigata University School of Medicine, Japan
    Biochem J 260:303-6. 1989
    ..Our result completely agreed with the amino acid sequence predicted from the cDNA analyses, providing evidence for the actual existence of the molecular species predicted from the cDNA...
  16. ncbi request reprint Methylenetetrahydrofolate reductase polymorphism in Kawasaki disease
    H Tsukahara
    Department of Pediatrics, Fukui Medical University, Japan
    Pediatr Int 42:236-40. 2000
    ..The hypothesis tested in the present study was that a higher proportion of Kawasaki disease (KD) patients with coronary artery lesions (CAL) would have the T677 allele compared with patients without CAL and healthy subjects...
  17. ncbi request reprint Clinical studies on three cases of the interval form of carbon monoxide poisoning: serial proton magnetic resonance spectroscopy as a prognostic predictor
    K Sakamoto
    Department of Neuropsychiatry, Fukui Medical University, Japan
    Psychiatry Res 83:179-92. 1998
    ..123I]IMP SPECT findings did not always reflectclinical symptomatology either. These results indicate that [1H]MRS is the most useful indicator in the clinical evaluation of patients with the interval form of CO poisoning...
  18. ncbi request reprint Brain perfusion SPECT study with 99mTc-bicisate: clinical pitfalls and improved diagnostic accuracy with a combination of linearization and scatter-attenuation correction
    H Kado
    Department of Radiology, Fukui Medical University, Yoshida gun, Japan
    Ann Nucl Med 15:123-9. 2001
    ..So that the linearization with the scatter-attenuation method is useful for improving the diagnostic accuracy of ECD-SPECT images...
  19. ncbi request reprint Tubulointerstitial nephritis with IgM-positive plasmacytoid large lymphocyte infiltration in a patient with primary biliary cirrhosis and Sjögren's syndrome
    N Takahashi
    Division of Nephrology, Department of General Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Clin Nephrol 74:74-80. 2010
    ..To our knowledge, this is the first report demonstrating predominant infiltrating of IgM-positive plasmacytoid large lymphocytes in TIN due to PBC and SS...
  20. ncbi request reprint Quantitative analysis of cerebral microvascular hemodynamics with T2-weighted dynamic MR imaging
    Y Koshimoto
    Department of Radiology, Fukui Medical University, Japan
    J Magn Reson Imaging 9:462-7. 1999
    ..This technique provides a new method for estimating cerebral microvascular hemodynamics...
  21. ncbi request reprint The leukotriene B4 receptor antagonist ONO-4057 inhibits nephrotoxic serum nephritis in WKY rats
    S Suzuki
    Department of Clinical and Laboratory Medicine, Fukui Medical University, Matsuoka, Japan
    J Am Soc Nephrol 10:264-70. 1999
    ..The LTB4 receptor antagonist ONO-4057 may thus be beneficial in the treatment of crescentic glomerulonephritis...
  22. pmc Neuronal damage in the interval form of CO poisoning determined by serial diffusion weighted magnetic resonance imaging plus 1H-magnetic resonance spectroscopy
    T Murata
    Department of Neuropsychiatry, Fukui Medical University, Matsuoka, Fukui 910 1193, Japan
    J Neurol Neurosurg Psychiatry 71:250-3. 2001
    ..Serial diffusion weighted imaging plus 1H-MRS measurements are useful in determining the tissue damage and long term outcome of delayed sequelae associated with the interval form of CO poisoning...
  23. ncbi request reprint Serial MRI and (1)H-MRS of Wernicke's encephalopathy: report of a case with remarkable cerebellar lesions on MRI
    T Murata
    Department of Neuropsychiatry, Fukui Medical University, 23 3 Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Psychiatry Res 108:49-55. 2001
    ..It is suggested that serial MRI/(1)H-MRS observation may be helpful in determining the neuronal viability of Wernicke's encephalopathy and the prognostic implications of sequelae such as Korsakoff's syndrome and cerebellar ataxia...
  24. pmc Oestrogen-related tumour phenotype: positron emission tomography characterisation with ¹⁸F-FDG and ¹⁸F-FES
    T Tsujikawa
    Biomedical Imaging Research Center, University of Fukui, Fukui, Japan, University of Fukui, Fukui, Japan
    Br J Radiol 85:1020-4. 2012
    ....
  25. ncbi request reprint Primary structure and cellular distribution of two fatty acid-binding proteins in adult rat kidneys
    H Kimura
    Department of Biochemistry, Niigata University School of Medicine, Japan
    J Biol Chem 266:5963-72. 1991
    ..5-kDa FABP immunostaining was observed predominantly in the endosomes or lysosomes of proximal tubules in male rat kidneys. These results suggest strongly the functional divergence of two FABPs in the rat kidney...
  26. ncbi request reprint Perfusion imaging of meningioma by using continuous arterial spin-labeling: comparison with dynamic susceptibility-weighted contrast-enhanced MR images and histopathologic features
    H Kimura
    Department of Radiology, Faculty of Medical Science, University of Fukui, Fukui, Japan
    AJNR Am J Neuroradiol 27:85-93. 2006
    ....
  27. ncbi request reprint Blocking angiotensin II ameliorates proteinuria and glomerular lesions in progressive mesangioproliferative glomerulonephritis
    T Nakamura
    Division of Blood Transfusion, Department of Internal Medicine, Niigata University School of Medicine, Niigata, Japan
    Kidney Int 55:877-89. 1999
    ....
  28. ncbi request reprint Endocapillary proliferative glomerulonephritis with crescent formation and concurrent tubulointerstitial nephritis complicating retroperitoneal fibrosis with a high serum level of IgG4
    K Katano
    Department of Internal Medicine, Fujita Memorial Hospital, Fukui, Japan
    Clin Nephrol 68:308-14. 2007
    ....
  29. ncbi request reprint Vasogenic edema on MELAS: a serial study with diffusion-weighted MR imaging
    M Yoneda
    Second Department of Internal Medicine, Fukui Medical University, Japan
    Neurology 53:2182-4. 1999
    ..DWI demonstrated a higher apparent diffusion coefficient in the lesion than in the control region during the acute stage of stroke. Vasogenic edema is present in stroke-like episodes in MELAS...
  30. ncbi request reprint Experimental nephropathy induced by Haemophilus parainfluenzae antigens
    C Yamamoto
    Department of Clinical and Laboratory Medicine, Fukui Medical University, Fukui, Japan
    Nephron 90:320-7. 2002
    ..In this study, we established an experimental model of IgAN using OMHP antigens and investigated the nephritogenicity of OMHP antigens...
  31. ncbi request reprint MRI white matter hyperintensities, (1)H-MR spectroscopy and cognitive function in geriatric depression: a comparison of early- and late-onset cases
    T Murata
    Department of Neuropsychiatry, Fukui Medical University, Matsuoka, Japan
    Int J Geriatr Psychiatry 16:1129-35. 2001
    ....
  32. ncbi request reprint Lewis and Secretor gene effects on Lewis antigen and postnatal development of Lewis blood type
    S Ameno
    Department of Forensic Medicine, Faculty of Medicine, Kagawa Medical University, Kagawa, Japan
    Biol Neonate 79:91-6. 2001
    ..In cord blood, the dosage effect of the Se gene on antigen levels was observed, but the Le gene effect was not observed. Both Se and Le gene effects were observed in newborn babies' blood 3-6 days after birth...
  33. ncbi request reprint Blood volume of gliomas determined by double-echo dynamic perfusion-weighted MR imaging: a preliminary study
    H Uematsu
    Department of Radiology, Fukui Medical University, Fukui, Japan
    AJNR Am J Neuroradiol 22:1915-9. 2001
    ..Double-echo imaging may be more suitable for the analysis of blood volume in GBMs...
  34. ncbi request reprint Fluorescence resonance energy transfer between points on tropomyosin and actin in skeletal muscle thin filaments: does tropomyosin move?
    M Miki
    Department of Applied Chemistry and Biotechnology, Fukui University, Fukui, 910 8507, Japan
    J Biochem 123:1104-11. 1998
    ..The present results do not support the notion of tropomyosin movement on skeletal muscle thin filaments as proposed in the steric blocking theory...
  35. ncbi request reprint Abnormal magnetization transfer ratios in normal-appearing white matter on conventional MR images of patients with occlusive cerebrovascular disease
    H Kado
    Department of Radiology, Fukui Medical University, 23 Shimoaizuki, Matsuoka, Yoshida-gun, Fukui 910-1193, Japan
    AJNR Am J Neuroradiol 22:922-7. 2001
    ..We believe that the MTR technique may partly replace PET data in the assessment of ischemic injury...
  36. ncbi request reprint Quantitative evaluation of magnetic resonance imaging of deep white matter hyperintensity in geriatric patients by multifractal analysis
    T Takahashi
    Department of Neuropsychiatry, Fukui Medical University, Fukui 910-1193, Japan
    Neurosci Lett 314:143-6. 2001
    ....
  37. ncbi request reprint Development of a simple whole blood panel test for detection of human heart-type fatty acid-binding protein
    T Watanabe
    Institute for Medical Research, Wakunaga Pharmaceutical Co, Ltd, 1624 Shimokotachi, Kodacho, Takatagun, Hiroshima 739-1195, Japan
    Clin Biochem 34:257-63. 2001
    ..Further studies are required to identify the value of this point-of-care testing (POCT) as a diagnostic marker for AMI...
  38. ncbi request reprint Isolation and characterization of novel presenilin binding protein
    A Kashiwa
    Salk Institute for Biological Studies Department of Pathology, University of California, La Jolla, California, USA
    J Neurochem 75:109-16. 2000
    ..immunohistochemical studies and cell fractionation analysis show that PBP redistributes from cytoplasm to membranes in the presence of PS. In addition, PBP is deficient in the soluble fraction of sporadic AD brains...
  39. ncbi request reprint Successful ex vivo normothermic liver perfusion with purely artificial products using artificial blood
    A Nui
    First Department of Surgery, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Int J Artif Organs 26:46-52. 2003
    ..These observations indicate that we have succeeded in developing an ex vivo functioning liver with an artificial perfusate employing artificial blood...
  40. ncbi request reprint Anticancer and radioprotective potentials of Mentha piperita
    Ashok Kumar
    Radiation and Cancer Biology Laboratory, University of Rajasthan, Jaipur 302004, India
    Biofactors 22:87-91. 2004
  41. ncbi request reprint Fate of (D-Ala2)-deltorphin-I-like immunoreactive neurons in 6-hydroxydopamine lesioned rat brain
    A Casini
    Department of Human Anatomy, University La Sapienza, Rome, Italy
    Eur J Histochem 48:135-40. 2004
    ..The consistent overlap of dopamine and this new molecule provides a further key to identifying the mammalian counterpart of these amphibian skin opioid peptides...
  42. ncbi request reprint Review of combination of peritoneal dialysis and hemodialysis as a modality of treatment for end-stage renal disease
    H Fukui
    Ther Apher Dial 8:56-61. 2004
    ..This treatment option is psychologically more acceptable to patients and may be expected to provide such accompanying beneficial effects as peritoneal resting, improvement of QOL and reduction in medical cost...
  43. ncbi request reprint c-kit Mutation in generalized lentigines associated with gastrointestinal stromal tumor
    Y Shibusawa
    Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan
    Dermatology 208:217-20. 2004
    ..We speculate that the generalized lentigines of the patient may be caused by melanocyte proliferation due to the c-kit gene mutation...
  44. ncbi request reprint Structure, expression and function of a schwannoma-derived growth factor
    H Kimura
    Salk Institute for Biological Studies, San Diego, California 92186 5800
    Nature 348:257-60. 1990
    ..SDGF belongs to the epidermal growth factor family, and is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts...
  45. ncbi request reprint N-acetylglucosamine-phosphate mutase genotype and diabetic microvascular complications
    H Pang
    Diabet Med 20:419-20. 2003
  46. ncbi request reprint Polymorphisms of sorbitol dehydrogenase (SDH) gene and susceptibility to diabetic retinopathy
    S Amano
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Med Hypotheses 60:550-1. 2003
    ..In this paper, we propose a novel hypothesis that polymorphisms of SDH gene may be correlated with SDH gene expression levels in diabetic retinas, thus being a valuable genetic marker for diabetic retinopathy...
  47. ncbi request reprint Alternative splicing mechanism in a cytochrome P-450 (P-450PB-1) gene generates the two mRNAs coding for proteins of different functions
    H Kimura
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    J Biol Chem 264:2338-42. 1989
    ..The function of this peptide remains to be seen...
  48. ncbi request reprint Infrainguinal arterial reconstruction for limb salvage in patients with end-stage renal disease
    H Kimura
    Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Eur J Vasc Endovasc Surg 25:29-34. 2003
    ..The prevalence of diabetes is higher in the ESRD group (p = 0.03)...
  49. ncbi request reprint Two non-amplified alleles at the canine microsatellite AHTh171 locus due to a single nucleotide transition in the primer-binding region
    M Nurimoto
    Maebashi Institute of Animal Science, Livestock Improvement Association of Japan, Inc, Maebashi 371 0121, Japan
    Anim Genet 36:281-2. 2005
  50. ncbi request reprint RASSF1A gene promoter methylation in esophageal cancer specimens
    S Yamaguchi
    Department of General Surgical Science, Gunma University Graduate School, Graduate School of Medicine, Maebashi, Gunma, Japan
    Dis Esophagus 18:253-6. 2005
    ..There was no correlation with its prognosis. In conclusion, it was suggested that an inactivation of the RASSF1A gene due to promoter methylation was associated with de-differentiation of the tumor in ESCC...
  51. pmc Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency
    Y Koda
    Department of Legal Medicine, Kurume University School of Medicine, Japan
    Am J Hum Genet 59:343-50. 1996
    ..A population study on 141 randomly selected Japanese has indicated that the se2 is a common Se enzyme-deficient allele in the Japanese population. The results suggest that Se enzyme-deficient alleles are race specific...
  52. ncbi request reprint Isolation and characterization of a full-length cDNA encoding the 55-kDa rabbit zona pellucida protein
    E Schwoebel
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 266:7214-9. 1991
    ....
  53. ncbi request reprint A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation
    Y Suzaki
    Second Dept of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara Nara 634 8522, Japan
    Eur Respir J 31:783-9. 2008
    ..Thus, CC chemokine receptor 5 and CXC chemokine receptor 3 may be potential targets for asthma therapy...
  54. ncbi request reprint Primary structure of a new actin-binding protein from human seminal plasma
    J Schaller
    Institute of Biochemistry, University of Bern, Switzerland
    Eur J Biochem 196:743-50. 1991
    ..Although SABP was also detected in saliva, in extracts of the submandibular gland and seminal vesicles, little is known of its function...
  55. ncbi request reprint Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression
    K Shi
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Biochem Biophys Res Commun 363:626-32. 2007
    ..In conclusion, membrane localization of PTP1B is essential for PP2A activation, which is crucial for its enhancement of SREBP-1 gene expression...
  56. ncbi request reprint Stochastic approach to molecular interactions and computational theory of metabolic and genetic regulations
    H Kimura
    Bio Mimetic Control Research Center, RIKEN, Shimo shidami, Moriyama ku, Nagoya 463 0003, Japan
    J Theor Biol 248:590-607. 2007
    ..Simple graphical methods to compute the equilibrium and non-equilibrium stationary distributions are derived based crucially on the probability flow, which dramatically simplifies the classical methods still used in enzymology...
  57. pmc An international parentage and identification panel for the domestic cat (Felis catus)
    M J Lipinski
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Anim Genet 38:371-7. 2007
    ..This international cat parentage and identification panel has a power of exclusion comparable to panels used in other species, ranging from 90.08% to 99.79% across breeds and 99.47% to 99.87% in random-bred cat populations...
  58. ncbi request reprint Molecular typing by pulsed-field gel electrophoresis of Flavobacterium psychrophilum isolates derived from Japanese fish
    H Arai
    Gunma Prefectural Fisheries Experiment Station, Maebashi, Gunma, Japan
    J Fish Dis 30:345-55. 2007
    ..These results suggest that F. psychrophilum isolated from ayu and other fish are genetically different and strains with several PFGE types have spread within Japan...
  59. ncbi request reprint Role of DNA methylation for expression of novel stem cell marker CDCP1 in hematopoietic cells
    H Kimura
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Leukemia 20:1551-6. 2006
    ..The methylation of DNA appeared to regulate the cell-type-specific expression of CDCP1 through the control of interaction between chromatin DNA and transcription factors...
  60. ncbi request reprint Epigenetic regulation of the expression of the novel stem cell marker CDCP1 in cancer cells
    J I Ikeda
    Department of Pathology, Osaka University Graduate School of Medicine, Yamada oka 2 2, Suita 565 0871, Japan
    J Pathol 210:75-84. 2006
    ..These findings indicate that the expression of CDCP1 is regulated by methylation of its promoter region in tumours. CDCP1 expression may prove to be useful in the further characterization of cancers...
  61. ncbi request reprint Female preponderance of Parkinson's disease in Japan
    H Kimura
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Neuroepidemiology 21:292-6. 2002
    ..0/100,000 women, showing that women were significantly more affected by PD than men (p < 0.001). Contrary to the findings in Europe and the USA, the results indicate a female preponderance of PD among the Japanese population...
  62. ncbi request reprint Haptoglobin genotype and diabetic microangiopathies in Japanese diabetic patients
    Y Koda
    Diabetologia 45:1039-40. 2002
  63. ncbi request reprint Identification of human phosphoglucomutase 3 (PGM3) as N-acetylglucosamine-phosphate mutase (AGM1)
    H Pang
    Division of Human Genetics, Department of Forensic Medicine, Kurume University School of Medicine, Japan
    Ann Hum Genet 66:139-44. 2002
    ....
  64. ncbi request reprint Functional analysis of the 5'-flanking region of FTA for expression of rat GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase
    M Soejima
    Division of Human Genetics, Department of Forensic Medicine, Kurume University School of Medicine, Kurume, Japan
    Eur J Biochem 266:274-81. 1999
    ..Deletional analysis of the 5'-flanking sequence revealed regions containing cell-type-specific positive acting element(s) and negative regulatory element(s), which are related to the promoter activity...
  65. ncbi request reprint Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene
    K Kitamura
    Department of Biochemistry, Nagoya City University Medical School, Nagoya, Japan
    DNA Res 6:291-7. 1999
    ....
  66. ncbi request reprint Blockade of secondary lymphoid tissue chemokine exacerbates Propionibacterium acnes-induced acute lung inflammation
    M Itakura
    Department of Molecular Preventive Medicine and Core Research for Evolutional Science and Technology, University of Tokyo School of Medicine, Bunkyoku, Tokyo, Japan
    J Immunol 166:2071-9. 2001
    ..These results indicate for the first time a regulatory role for SLC-recruited mature DCs in bridging an acute inflammatory response (innate immunity) and acquired immunity in the lung...
  67. pmc Kinetics of core histones in living human cells: little exchange of H3 and H4 and some rapid exchange of H2B
    H Kimura
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Cell Biol 153:1341-53. 2001
    ..These results reveal that the inner core of the nucleosome is very stable, whereas H2B on the surface of active nucleosomes exchanges continually...
  68. ncbi request reprint Lipopolysaccharide-induced switch between retinoid receptor (RXR) alpha and glucocorticoid attenuated response gene (GARG)-16 messenger RNAs in cultured rat microglia
    Y Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    J Neurosci Res 64:553-63. 2001
    ..The counter regulatory control of GARG16 and RXRalpha mRNA expression is believed to be an example of a fine-tuned cellular mechanism to react to inflammatory stimuli...
  69. ncbi request reprint PAL31, a nuclear protein required for progression to the S phase
    W Sun
    Laboratory of Cellular Biochemistry, Animal Resource Sciences Veterinary Medical Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Biochem Biophys Res Commun 280:1048-54. 2001
    ..Furthermore, the antisense oligonucleotide for PAL31 severely inhibited the proliferation of Nb2 cells by inhibiting cells progressing to the S phase. Thus, PAL31 is a nuclear protein associated with cell cycle progression...
  70. ncbi request reprint Hypervascular liver metastasis from hypovascular ductal cell carcinoma of the pancreas
    A Noda
    Department of Internal Medicine, Fukuchiyama City Hospital, Kyoto
    Intern Med 40:227-31. 2001
    ..It was suggested that the difference in the stromal volume was related to the difference of the vascularity. Some foctors originating in stromal cells might be involved in angiogenesis...
  71. ncbi request reprint Stage-specific modification of G protein beta subunits in rat placenta
    R Ishimura
    Laboratory of Cellular Biochemistry, Department of Veterinary Medical Sciences/Animal Resource Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-8657, Tokyo, Japan
    Mol Cell Endocrinol 174:77-89. 2001
    ..In conclusion, there are modified forms of G protein beta1 and beta2 subunits, in the placenta and Rcho-1 cells, which are expressed in a pregnancy-stage or differentiation stage specific manner...
  72. ncbi request reprint Fulminant hepatitis by Fas-ligand expression in MRL-lpr/lpr mice grafted with Fas-positive livers and wild-type mice with Fas-mutant livers
    X K Li
    Department of Experimental Surgery and Bioengineering, National Children's Medical Research Center, Tokyo, Japan
    Transplantation 71:503-8. 2001
    ..These findings are important for generating a new strategy to prevent hepatitis as well as for understanding the role of the Fas/FasL interaction in the pathophysiology of hepatitis...
  73. ncbi request reprint DNA methylation regulates placental lactogen I gene expression
    J H Cho
    Laboratory of Cellular Biochemistry, Animal Resource Sciences/Veterinary Medical Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan
    Endocrinology 142:3389-96. 2001
    ..These results provide evidence that change in DNA methylation is the fundamental mechanism regulating the tissue-specific expression of the rat placental lactogen I gene...
  74. pmc Quantitation of RNA polymerase II and its transcription factors in an HeLa cell: little soluble holoenzyme but significant amounts of polymerases attached to the nuclear substructure
    H Kimura
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Mol Cell Biol 19:5383-92. 1999
    ....
  75. ncbi request reprint Severe hepatitis caused by Epstein-Barr virus without infection of hepatocytes
    H Kimura
    Departments of Pediatrics, Clinical Pathology, and Health Science, Nagoya University School of Medicine; and the Laboratory of Viral Oncology, Aichi Cancer Research Institute, Nagoya, Japan
    Hum Pathol 32:757-62. 2001
    ..The CD8(+) T cells, not hepatocytes, were positive for EBV. Possible mechanisms of viral hepatitis without infection of hepatocytes are discussed...
  76. ncbi request reprint Complementary DNA cloning of cytochrome P-450s related to P-450(M-1) from the complementary DNA library of female rat livers. Predicted primary structures for P-450f, PB-1, and PB-1-related protein with a bizarre replacement block and their mode of transc
    H Kimura
    Department of Biochemistry, Japanese Foundation for Cancer Research, Tokyo
    J Biol Chem 263:701-7. 1988
    ..In addition, both the mRNAs were specifically expressed in the female brain of 8 weeks, whereas practically no expression was observed in kidney and lung of both sexes...
  77. ncbi request reprint Ehlers-Danlos syndrome type IV with few extrathoracic findings: a newly recognized point mutation in the COL3A1 gene
    A Watanabe
    Dept of Respirology, Graduate School of Medicine, Chiba University, Chiba City, Japan
    Eur Respir J 19:195-8. 2002
    ..In the present case, connective tissue friability was suspected due to tissue laceration observed in the biopsied lung specimen, and the diagnosis was made beginning from this pivotal finding...
  78. ncbi request reprint [Examination of eye position after strabismus surgery in Kawasaki Medical School Hospital]
    T Akatsuka
    Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan
    Nippon Ganka Gakkai Zasshi 105:781-7. 2001
    ..In individual cases, the factors which affect position of eyes were examined, and it was considered necessary to increase the amount of correction. Age is a factor which has an effect, but the effect on esotropia and exotropia is small...
  79. ncbi request reprint Binding of human minichromosome maintenance proteins with histone H3
    Y Ishimi
    Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194, Japan
    J Biol Chem 271:24115-22. 1996
    ..Immunoprecipitation with anti-Cdc21 antibody revealed that these four MCM proteins form complexes. These results are consistent with the findings that MCM proteins bind with chromatin in vivo...
  80. ncbi request reprint Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2)
    Y Koda
    Department of Forensic Medicine, Kurume University School of Medicine, Japan
    Eur J Biochem 246:750-5. 1997
    ..The presence of a large stem-and-loop structure in the 3' untranslated region may regulate the level of the FUT2 transcript by affecting the stability of the mRNA...
  81. ncbi request reprint Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa
    H Pang
    Department of Forensic Medicine, Kurume University School of Medicine, Fukuoka, Japan
    Hum Genet 102:675-80. 1998
    ....
  82. pmc Schwannoma-derived growth factor promotes the neuronal differentiation and survival of PC12 cells
    H Kimura
    Salk Institute, San Diego, California 92186 5800
    J Cell Biol 116:777-83. 1992
    ..These observations show that SDGF has a differentiation and survival promoting effect on PC12 cells in addition to its mitogenic activity on glial cells and fibroblasts...
  83. ncbi request reprint Reduced expression of flice-inhibitory protein (FLIP) and NFkappaB is associated with death receptor-induced cell death in human aortic endothelial cells (HAECs)
    Y Okada
    Department of Pediatrics, Gunma University School of Medicine, Maebashi, Gunma 371-8511, Japan
    Cytokine 15:66-74. 2001
    ..Cells insensitive to TNF-alpha may respond to TNF-alpha through TNFR that induces transcription of NFkappaB1 and FLIP. Down-regulation of these proteins may facilitate death of cells insensitive to TNF-alpha-induced cell death...
  84. ncbi request reprint SH2D1A mutations in Japanese males with severe Epstein-Barr virus--associated illnesses
    R Sumazaki
    Department of Pediatrics, Institute of Clinical Medicine, University of Tsukuba, Japan
    Blood 98:1268-70. 2001
    ..Thus, genetic analysis of the SH2D1A gene is particularly useful in the diagnosis of sporadic cases and carriers of XLP. (Blood. 2001;98:1268-1270)..
  85. ncbi request reprint Germline BRCA1 mutations in Iranian women with breast cancer
    A Ghaderi
    Department of Immunology, Medical School, Shiraz University of Medical Sciences, P O Box 71345 1798, Shiraz, Iran
    Cancer Lett 165:87-94. 2001
    ..Three of these polymorphic sites were placed in the intronic part of the gene. To understand the significance of the contribution of the BRCA1 gene in the breast cancer among Iranian, further investigations are needed...