Masaru Katoh

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint RNA technology targeted to the WNT signaling pathway
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Biol Ther 7:275-7. 2008
  2. pmc Therapeutics targeting angiogenesis: genetics and epigenetics, extracellular miRNAs and signaling networks (Review)
    Masaru Katoh
    Division of Integrative Omics and Bioinformatics, National Cancer Center, Tokyo 104 0045, Japan
    Int J Mol Med 32:763-7. 2013
  3. pmc Functional and cancer genomics of ASXL family members
    M Katoh
    Division of Integrative Omics and Bioinformatics, National Cancer Centre, 5 1 1 Tsukiji, Chuo Ward, Tokyo, Japan
    Br J Cancer 109:299-306. 2013
  4. pmc Functional proteomics, human genetics and cancer biology of GIPC family members
    Masaru Katoh
    Division of Integrative Omics and Bioinformatics, National Cancer Centre, Tokyo, Japan
    Exp Mol Med 45:e26. 2013
  5. pmc Function and cancer genomics of FAT family genes (review)
    Masaru Katoh
    Division of Integrative Omics and Bioinformatics, National Cancer Center, Tokyo 104 0045, Japan
    Int J Oncol 41:1913-8. 2012
  6. ncbi request reprint Integrative genomic analyses on GLI2: mechanism of Hedgehog priming through basal GLI2 expression, and interaction map of stem cell signaling network with P53
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 33:881-6. 2008
  7. ncbi request reprint Transcriptional regulation of WNT2B based on the balance of Hedgehog, Notch, BMP and WNT signals
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 34:1411-5. 2009
  8. ncbi request reprint WNT signaling in stem cell biology and regenerative medicine
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Curr Drug Targets 9:565-70. 2008
  9. ncbi request reprint Cancer genomics and genetics of FGFR2 (Review)
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, Chuo Ward, Tokyo 104 0045, Japan
    Int J Oncol 33:233-7. 2008
  10. ncbi request reprint Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Stem Cell Rev 3:30-8. 2007

Detail Information

Publications99

  1. ncbi request reprint RNA technology targeted to the WNT signaling pathway
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Biol Ther 7:275-7. 2008
  2. pmc Therapeutics targeting angiogenesis: genetics and epigenetics, extracellular miRNAs and signaling networks (Review)
    Masaru Katoh
    Division of Integrative Omics and Bioinformatics, National Cancer Center, Tokyo 104 0045, Japan
    Int J Mol Med 32:763-7. 2013
    ..A more profound understanding of the spatio-temporal interactions of regulatory signaling cascades and advances in personal genotyping and miRNA profiling are required for the optimization of targeted therapy...
  3. pmc Functional and cancer genomics of ASXL family members
    M Katoh
    Division of Integrative Omics and Bioinformatics, National Cancer Centre, 5 1 1 Tsukiji, Chuo Ward, Tokyo, Japan
    Br J Cancer 109:299-306. 2013
    ..The prognosis of myeloid malignancies with misregulating truncation mutations of ASXL1 is poor. ASXL family members are assumed to be tumour suppressive or oncogenic in a context-dependent manner. ..
  4. pmc Functional proteomics, human genetics and cancer biology of GIPC family members
    Masaru Katoh
    Division of Integrative Omics and Bioinformatics, National Cancer Centre, Tokyo, Japan
    Exp Mol Med 45:e26. 2013
    ..As GIPC proteins are involved in trafficking, signaling and recycling of RTKs, GPCRs, integrins and other transmembrane proteins, dysregulation of GIPCs results in human pathologies, such as cancer and hereditary deafness...
  5. pmc Function and cancer genomics of FAT family genes (review)
    Masaru Katoh
    Division of Integrative Omics and Bioinformatics, National Cancer Center, Tokyo 104 0045, Japan
    Int J Oncol 41:1913-8. 2012
    ....
  6. ncbi request reprint Integrative genomic analyses on GLI2: mechanism of Hedgehog priming through basal GLI2 expression, and interaction map of stem cell signaling network with P53
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 33:881-6. 2008
    ....
  7. ncbi request reprint Transcriptional regulation of WNT2B based on the balance of Hedgehog, Notch, BMP and WNT signals
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 34:1411-5. 2009
    ..BMP-IHH and inflammation-SHH signaling loops are involved in WNT2B up-regulation during embryogenesis, adult tissue homeostasis, and carcinogenesis...
  8. ncbi request reprint WNT signaling in stem cell biology and regenerative medicine
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Curr Drug Targets 9:565-70. 2008
    ..Recombinant WNT protein or WNT mimetic (circular peptide, small molecule compound, or RNA aptamer) in combination with Notch mimetic, FGF protein, and BMP protein opens a new window to tissue engineering for regenerative medicine...
  9. ncbi request reprint Cancer genomics and genetics of FGFR2 (Review)
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, Chuo Ward, Tokyo 104 0045, Japan
    Int J Oncol 33:233-7. 2008
    ..FGFR2ome analyses in patients with several tumor types among various populations should be carried out to establish integrative database of FGFR2 for the rational clinical application of FGFR2-targeted cancer therapy...
  10. ncbi request reprint Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Stem Cell Rev 3:30-8. 2007
    ..Disruption of the stem cell signaling network results in pathological conditions, such as congenital diseases and cancer...
  11. ncbi request reprint Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 20:405-9. 2007
    ..Non-canonical WNT or PCP signaling pathway, activated to orchestrate gastrulation and neurulation, was relatively downregulated in undifferentiated ES cells derived from inner cell mass of blastocysts...
  12. ncbi request reprint Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 31:461-6. 2007
    ..Together these facts indicate that HES1 and HES3 were target genes of the ES cell-specific network of transcription factors, and that HES1, HES5, HEY1, HEY2 and HEYL were target genes of Notch signaling pathway...
  13. ncbi request reprint Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancer
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045 Japan
    Cancer Biol Ther 6:832-9. 2007
    ..SNP typing and custom-made microarray analyses on genes encoding stem cell signaling molecules could be utilized for the personalized medicine...
  14. ncbi request reprint STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (Review)
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 19:273-8. 2007
    ..Humanized anti-IL6 receptor antibody and WNT5A mimetic small-molecule antagonist could be applied to personalized medicine for RA and cancer driven by the IL6-induced WNT5A signaling loop...
  15. doi request reprint FGFR2 abnormalities underlie a spectrum of bone, skin, and cancer pathologies
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center, Tokyo, Japan
    J Invest Dermatol 129:1861-7. 2009
    ..Dysregulation of FGFR2 results in a spectrum of bone and skin pathologies and several types of cancer...
  16. ncbi request reprint Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 19:529-33. 2007
    ..Comparative genomics analyses revealed that the binding sites for PU.1, SP1/Krüppel-like, CCAAT-box, and TCF/LEF/SOX transcription factors were conserved among 5'-promoter regions of mammalian FZD7 orthologs...
  17. ncbi request reprint Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 23:763-9. 2009
    ..Together these facts indicate that WNT5A is transcribed based on multiple mechanisms, such as NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades...
  18. ncbi request reprint Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 30:751-5. 2007
    ..Together, these facts indicate that POU5F1 and POU2F subfamily members play a pivotal role for the FZD5 expression in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer...
  19. ncbi request reprint Genetic alterations of FGF receptors: an emerging field in clinical cancer diagnostics and therapeutics
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center, 5 1 1 Tsukiji, Chuo Ward, Tokyo 104 0045, Japan
    Expert Rev Anticancer Ther 10:1375-9. 2010
    ..Diagnostic detection of tumors with FGFR genetic alterations in primary lesion, peritoneal effusion, pleural effusion and bone marrow is necessary to select patients for FGFR-targeted therapeutics...
  20. ncbi request reprint Network of WNT and other regulatory signaling cascades in pluripotent stem cells and cancer stem cells
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Curr Pharm Biotechnol 12:160-70. 2011
    ....
  21. ncbi request reprint MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, encodes secreted-type protein with conserved cysteine residues
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:235-41. 2003
    ..MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, was found to encode secreted-type protein with six conserved cysteine residues...
  22. ncbi request reprint Comparative genomics on FGF20 orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 14:287-90. 2005
    ..Double TCF/LEF binding sites, double EVI1-binding sites, TGIF, PAX4, E47 and AREB6-binding sites were conserved between human FGF20 promoter and mouse Fgf20 promoter...
  23. ncbi request reprint Molecular cloning and characterization of Strabismus 2 (STB2)
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 20:993-8. 2002
    ..On the other hand, STB2 mRNA was significantly down-regulated in a pancreatic cancer cell line AsPC-1. This is the first report on molecular cloning and characterization of STB2...
  24. ncbi request reprint Comparative genomics on Wnt16 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 13:771-5. 2005
    ..Double CCAAT motifs were conserved among mammalian Wnt16 promoters. This is the first report on the rat Wnt16 and zebrafish wnt16 genes, as well as the double CCAAT motifs within the core promoter regions of mammalian Wnt16 orthologs...
  25. ncbi request reprint Comparative genomics on SOX2 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 14:797-800. 2005
    ..Due to the pivotal role of SOX2 in the early embryogenesis, SOX2 promoter and SOX2 protein were well conserved during vertebrate evolution. This is the first report on comparative integromics analyses on the SOX2 orthologs...
  26. ncbi request reprint Germ-line mutation of Foxn5 gene in mouse lineage
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 14:463-7. 2004
    ..This is the first report on identification and characterization of mouse Foxn5 gene as well as on species specific germ-line mutation of the Fox family gene...
  27. ncbi request reprint Expression of human SOX18 in normal tissues and tumors
    Tetsuroh Saitoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 10:339-44. 2002
    ..Expression level of SOX18 mRNA in NT2 cells was down-regulated by all-trans retinoic acid. This is the first report on comprehensive expression analyses of SOX18 mRNA in normal human tissues and tumors...
  28. ncbi request reprint Comparative genomics on Fgf11 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 14:291-4. 2005
    ..Human FGF11 mRNA was expressed in embryonic stem (ES) cells, neuroblastoma, retinoblastoma, and brain tumors. This is the first report on the dog Fgf11 gene as well as on comparative genomics analyses of Fgf11 orthologs...
  29. ncbi request reprint Identification and characterization of rat Dact1 and Dact2 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 15:1045-9. 2005
    ..DAPH3 domain was the Serine rich region. DAPH7 domain was the C-terminal PDZ binding region. This is the first report on the rat Dact1 and Dact2 genes...
  30. ncbi request reprint Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 20:269-73. 2007
    ....
  31. ncbi request reprint Comparative genomics on Dkk1 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo, Japan
    Int J Oncol 27:275-9. 2005
    ..Double TCF/LEF-binding sites within the proximal promoter region of mammalian Dkk1 orthologs are implicated in the negative feed back mechanism of WNT/beta-catenin signaling pathway...
  32. ncbi request reprint Identification and characterization of Crumbs homolog 2 gene at human chromosome 9q33.3
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 24:743-9. 2004
    ..3 and CRB1-MGC27044-LHX9-NEK7 locus at human chromosome 1q31.3 were paralogous regions within the human genome. This is the first report on identification and characterization of the CRB2 gene...
  33. ncbi request reprint Comparative genomics on Fzd7 orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 15:1051-5. 2005
    ..These facts indicate that experimental data obtained by using FzE3 cDNA do not always reflect the functions of Fzd7 orthologs...
  34. ncbi request reprint Comparative genomics on BMP4 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 27:581-5. 2005
    ..FOXA2, OLF1, and MYC-binding sites were conserved among the major promoter region of human, baboon, cow, bat, mouse and rat BMP4 orthologs...
  35. ncbi request reprint Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 14:333-8. 2004
    ..This is the first report on identification and characterization of the ARHGAP24 and ARHGAP25 genes...
  36. ncbi request reprint Comparative genomics on Wnt7a orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 13:777-80. 2005
    ..Therefore, biological functions of rodent Wnt7a are not always consistent with those of human WNT7A due to promoter evolution. This is the first report on the rat Wnt7a gene and comparative genomics for Wnt7a orthologs...
  37. ncbi request reprint Comparative genomics on SFRP1 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 27:861-5. 2005
    ..Match program revealed that AP1, COMP1, and double ETS1-binding sites were conserved between human SFRP1 and rat Sfrp1 promoters. This is the first report on comparative integromics analyses on Sfrp1 orthologs...
  38. ncbi request reprint Comparative genomics on FGF7, FGF10, FGF22 orthologs, and identification of fgf25
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 16:767-70. 2005
    ..This is the first report on fgf25 gene and also on the comparative integromics analyses of FGF7, FGF10 and FGF22 orthologs...
  39. ncbi request reprint Comparative genomics on SFRP2 orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 14:783-7. 2005
    ..This is the first report on comparative integromics analyses on SFRP2 orthologs...
  40. ncbi request reprint Identification and characterization of human DAPPER1 and DAPPER2 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:907-13. 2003
    ..Based on evolutionary and functional conservation of WNT signaling molecules as well as human chromosomal localization, DAPPER1 and DAPPER2 genes are predicted to be potent cancer-associated genes...
  41. ncbi request reprint Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:1161-8. 2003
    ..FMNL1, FMNL2 and FMNL3 might be implicated in polarity control, invasion, migration, or metastasis through regulation of the Rho-related signaling pathway...
  42. ncbi request reprint KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:145-50. 2003
    ..0 kb. KIAA1735 gene on human chromosome 11q23.1 was located between D11S1391 and D11S1347 loci, the region deleted in sporadic breast cancer. This is the first report on comprehensive characterization of the KIAA1735 gene...
  43. ncbi request reprint Identification and characterization of human LL5A gene and mouse Ll5a gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:1477-83. 2003
    ..LL5alpha protein might be a transducer of PtdIns(3,4,5)P3 levels to the intracellular trafficking system...
  44. ncbi request reprint Molecular cloning and characterization of OSR1 on human chromosome 2p24
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 10:221-5. 2002
    ..Among 10 cases of primary gastric cancer, OSR1 mRNA was up-regulated in 5 cases, and was down-regulated in 2 cases. This is the first report on molecular cloning and characterization of human OSR1...
  45. ncbi request reprint Identification and characterization of human FHOD3 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 13:615-20. 2004
    ..Human FHOD3, FHOD1 and Drosophila CG32030 were found to share the conserved domain structure consisting of FHDHN, FH1, FH2, and FHDHC domains. This is the first report on the FHOD3 gene as well as on the novel FHDHN and FHDHC domains...
  46. ncbi request reprint Identification and characterization of JMJD2 family genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 24:1623-8. 2004
    ..This is the first report on identification and characterization of human JMJD2 gene family...
  47. ncbi request reprint Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells
    Tetsuroh Saitoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 20:999-1003. 2002
    ..WNT8A and WNT8B might play key roles in embryonal tumors and embryonic stem cells through synergistic activation of the beta-catenin - TCF signaling pathway...
  48. ncbi request reprint Comparative genomics on SNAI1, SNAI2, and SNAI3 orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 14:1083-6. 2005
    ..SNAI1, functioning as E-cadherin repressor, is implicated in the malignant infiltrating phenotype of diffuse type gastric cancer through the induction of EMT or fibroblastoid transformation...
  49. ncbi request reprint Identification and characterization of human FCHO2 and mouse Fcho2 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 14:327-31. 2004
    ..elegans 2B609 were found consisting of N-terminal FCH domain and C-terminal FOH domain. This is the first report on identification and characterization of evolutionarily conserved FCHO homologs as well as the novel FOH domain...
  50. ncbi request reprint Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 17:681-5. 2006
    ..JAG1, functioning as WNT-dependent Notch signaling activator, is the key molecule maintaining the homeostasis of stem and progenitor cells...
  51. ncbi request reprint Comparative genomics on FGF8, FGF17, and FGF18 orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo, Japan
    Int J Mol Med 16:493-6. 2005
    ..These facts indicate that FGF18 orthologs were evolutionarily conserved targets of the WNT/beta-catenin signaling pathway...
  52. ncbi request reprint Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 24:757-63. 2004
    ..The evolutionary recombination hotspot and oncogenomic recombination hotspot might be clustered around the fragile sites within the human genome...
  53. ncbi request reprint Identification and characterization of TPARM gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:1213-7. 2003
    ..2. TPARM as well as NCAM1 and DRD2 were predicted to be candidate tumor suppressor genes within the commonly deleted region of malignant melanoma on 11q23.1-q23.2 (between microsatellite markers D11S1347 and D11S4122)...
  54. ncbi request reprint Identification and characterization of TMEM16E and TMEM16F genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 24:1345-9. 2004
    ..TMEM16 family members were eight-transmenbrane proteins with TM16H1-TM16H3 domains and a conserved Asn glycosylation site. This is the first report on TMEM16E and TMEM16F genes...
  55. ncbi request reprint Identification and characterization of human FCHSD1 and FCHSD2 genes in silico
    Masuko Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 13:749-54. 2004
    ..This is the first report on identification and characterization of the FCHSD family genes...
  56. ncbi request reprint Identification and characterization of ASXL3 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 24:1617-22. 2004
    ..1 and ASXL2-DTNB locus at 2p23.3 were paralogous regions within the human genome. ASXL3 was a predicted cancer-associated gene, just like ASXL1 and ASXL2. This is the first report on identification and characterization of the ASXL3 gene...
  57. ncbi request reprint Up-regulation of WNT8B mRNA in human gastric cancer
    Tetsuroh Saitoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 20:343-8. 2002
    ..WNT8B might play key roles in gastric cancer through activation of the beta-catenin - TCF signaling pathway...
  58. ncbi request reprint Identification and characterization of mouse Ppfia1 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 12:263-7. 2003
    ..This is the first report on mouse Ppfia1 gene as well as comprehensive comparison of CCND1-EMS1 locus within the human and mouse genomes...
  59. ncbi request reprint Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:1471-6. 2003
    ..This is the first report on the comprehensive characterization of human KIAA1391 gene and mouse Kiaa1391 gene, encoding RhoGAP proteins with RA domain and two ANXL repeats...
  60. ncbi request reprint Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer
    Hiroyuki Kirikoshi
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 21:895-900. 2002
    ..beta-estradiol did not affect expression levels of WNT7A and WNT7B in MCF-7 cells. WNT7B, but not WNT7A, was slightly up-regulated by all-trans retinoic acid in NT2 cells...
  61. ncbi request reprint Molecular cloning and characterization of WRCH2 on human chromosome 15q15
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 20:977-82. 2002
    ..Because Wrch1 can activate PAK1 and JNK1, and induce filopodium formation and stress fiber dissolution, over-expression of WRCH2 mRNA in human cancer cells might also lead to more malignant phenotype...
  62. ncbi request reprint Molecular cloning and characterization of human GIPC3, a novel gene homologous to human GIPC1 and GIPC2
    Tetsuroh Saitoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 20:577-82. 2002
    ..This is the first report on molecular cloning of GIPC3, the third member of the GIPC gene family...
  63. ncbi request reprint Comparative genomics on mammalian Fgf6-Fgf23 locus
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 16:355-8. 2005
    ..This is the first report on comparative genomics analyses on human FGF6-FGF23 gene cluster and rodents Fgf6-Fgf23 gene cluster...
  64. ncbi request reprint Molecular cloning and expression of proto-oncogene FRAT1 in human cancer
    Tetsuroh Saitoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 20:785-9. 2002
    ..This is the first report on isolation of FRAT1 cDNA derived from the more common FRAT1 allele, and also on regulation of FRAT1 mRNA in human cancer cells...
  65. ncbi request reprint Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico
    Yuriko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Oncol Rep 12:939-43. 2004
    ..Mammalian CDC50 homologs were predicted components of phospholipid-translocators just like yeast Cdc50p and Lem3p...
  66. ncbi request reprint Identification and characterization of human HES2, HES3, and HES5 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 25:529-34. 2004
    ..Phylogenetic analyses revealed that HES family proteins were distantly related except a paralog pair of HES1 and HES4. HES family genes are pharmacogenomic targets in the field of regenerative medicine and oncology...
  67. ncbi request reprint Identification and characterization of TMEM16H gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 15:353-8. 2005
    ..This is the first report on identification and characterization of the TMEM16H gene as well as on the molecular evolution of TMEM16H...
  68. ncbi request reprint Comparative genomics on mammalian Fgf3-Fgf4 locus
    Masuko Katoh
    M and M Medical BioInformatics, Hongo, Japan
    Int J Oncol 27:281-5. 2005
    ..11) and the NFAM1 locus (22q13.2). FGF34Rep2 was characterized by the CCA(T/C) repeats. This is the first report on comparative genomics analyses on the Fgf3-Fgf4 locus within human, rat and mouse genomes...
  69. ncbi request reprint Integrative genomic analyses of CXCR4: transcriptional regulation of CXCR4 based on TGFbeta, Nodal, Activin signaling and POU5F1, FOXA2, FOXC2, FOXH1, SOX17, and GFI1 transcription factors
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 36:415-20. 2010
    ....
  70. ncbi request reprint Comparative integromics on Ephrin family
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 15:1391-5. 2006
    ..EFNB3, identified as potential transcriptional target of WNT/beta-catenin signaling pathway, is a pharmacogenomics target in the fields of regenerative medicine and oncology...
  71. ncbi request reprint AP1- and NF-kappaB-binding sites conserved among mammalian WNT10B orthologs elucidate the TNFalpha-WNT10B signaling loop implicated in carcinogenesis and adipogenesis
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 19:699-703. 2007
    ..Inhibitors of TNFalpha-WNT10B signaling loop could be utilized for the prevention or treatment of cancer associated with chronic inflammation, such as gastric, liver, breast and pancreatic cancer...
  72. ncbi request reprint FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo, Japan
    Int J Mol Med 17:529-32. 2006
    ..Epigenetic silencing and loss-of-function mutations of SPRY4 gene in progenitor cells could lead to carcinogenesis. SPRY4 is the pharmacogenomics target in the fields of oncology and regenerative medicine...
  73. ncbi request reprint Comparative genomics on ROR1 and ROR2 orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 14:1381-4. 2005
    ..WNT5A and ROR family receptors, co-expressed in ES cells and gastric cancer, are implicated in the planar cell polarity (PCP) pathway. ROR1 and ROR2 are the pharmacogenomics targets in the fields of stem cell biology and oncology...
  74. ncbi request reprint Canonical WNT signaling pathway and human AREG
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo, Japan
    Int J Mol Med 17:1163-6. 2006
    ..AREG is a target of systems medicine in the field of oncology...
  75. ncbi request reprint Comparative integromics on BMP/GDF family
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 17:951-5. 2006
    ..Because GDF10 was characterized as a potential target of canonical WNT signaling pathway in neural tissues, GDF10 is one of the targets of systems medicine, especially in the field of regenerative medicine...
  76. ncbi request reprint Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1alpha, POU/OCT, and NF-kappaB
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 34:1737-42. 2009
    ..Together these facts indicate that ZEB2, occupying the crossroads of inflammation, aging and carcinogenesis, is an important target for drug discovery...
  77. ncbi request reprint Comparative genomics on DKK2 and DKK4 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo, Japan
    Int J Mol Med 16:477-81. 2005
    ..DKK4 orthologs are implicated in the negative feed back mechanism of the WNT/beta-catenin signaling pathway (the canonical WNT signaling pathway)...
  78. ncbi request reprint Identification and characterization of human SNAIL3 (SNAI3) gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 11:383-8. 2003
    ..Because SNAG zinc-finger proteins are transcriptional repressors implicated in carcinogenesis and embryogenesis, SNAI3 gene might be a potent target of pharmacogenomics in the field of oncology and regenerative medicine...
  79. ncbi request reprint Integrative genomic analyses of WNT11: transcriptional mechanisms based on canonical WNT signals and GATA transcription factors signaling
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 24:247-51. 2009
    ..Canonical WNT-to-WNT11 signaling loop is involved in cellular migration during embryogenesis as well as tumor invasion during carcinogenesis...
  80. ncbi request reprint Identification and characterization of ASXL2 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:845-50. 2003
    ..Based on functional conservation and human chromosomal localization, ASXL2 and ASXL1 genes were predicted cancer-associated genes...
  81. ncbi request reprint Identification and characterization of mouse Erbb2 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:831-5. 2003
    ..This is the first report on the complete coding sequence of mouse Erbb2 gene as well as on the comprehensive comparison of Ppp1r1b-Grb7 locus within the human and mouse genomes...
  82. ncbi request reprint Recombination cluster around FGFR2-WDR11-HTPAPL locus on human chromosome 10q26
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 11:579-83. 2003
    ..Therefore, comparative genomics might be applicable to identification of recombination hot spots and genes related to cancer...
  83. ncbi request reprint IGSF11 gene, frequently up-regulated in intestinal-type gastric cancer, encodes adhesion molecule homologous to CXADR, FLJ22415 and ESAM
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:525-31. 2003
    ..Because IGSF11 gene is frequently up-regulated in intestinal-type gastric cancer, IGSF11 protein might be clinically applied as targets for early diagnosis of gastric cancer as well as for drug delivery to gastric cancer...
  84. ncbi request reprint Comparative genomics on Sonic hedgehog orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 14:1087-90. 2005
    ..5) was identified. Double bHLH binding sites, CCAAT box, and TATA box were conserved among human SHH promoter, chimpanzee SHH promoter, rat Shh promoter, and mouse Shh promoter...
  85. ncbi request reprint Comparative integromics on JMJD1C gene encoding histone demethylase: conserved POU5F1 binding site elucidating mechanism of JMJD1C expression in undifferentiated ES cells and diffuse-type gastric cancer
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 31:219-23. 2007
    ..POU5F1-mediated expression of JMJD1C histone demethylase is implicated in the reactivation of silenced genes in undifferentiated ES cells, pancreatic islet, and diffuse-type gastric cancer...
  86. ncbi request reprint Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo, Japan
    Int J Oncol 30:1273-7. 2007
    ....
  87. ncbi request reprint Comparative integromics on Angiopoietin family members
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo, Japan
    Int J Mol Med 17:1145-9. 2006
    ..Human ANGPTL7, characterized as potent target gene of WNT/ beta-catenin signaling pathway, is a pharmacogenomics target in the fields of oncology and regenerative medicine...
  88. ncbi request reprint Comparative genomics on Fzd8 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 13:993-7. 2005
    ..Match program revealed that ELK1- and PAX4-binding sites were conserved between rat Fzd8 and human FZD8 promoters. This is the first report on the rat Fzd8 gene as well as on comparative genomics for Fzd8 orthologs...
  89. ncbi request reprint Bioinformatics for cancer management in the post-genome era
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Technol Cancer Res Treat 5:169-75. 2006
    ....
  90. ncbi request reprint Human FOX gene family (Review)
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 25:1495-500. 2004
    ....
  91. ncbi request reprint Comparative genomics on Wnt8a and Wnt8b genes
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 26:1129-33. 2005
    ..This is the first report on the rat Wnt8a and Wnt8b genes as well as on the conserved GATA-binding site within rat Wnt8b and human WNT8B promoters...
  92. ncbi request reprint WNT antagonist, DKK2, is a Notch signaling target in intestinal stem cells: augmentation of a negative regulation system for canonical WNT signaling pathway by the Notch-DKK2 signaling loop in primates
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 19:197-201. 2007
    ..Together, these facts indicate that DKK2 promoter evolution resulted in the augmentation of a WNT negative regulation system in primates...
  93. ncbi request reprint Characterization of KIF7 gene in silico
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 25:1881-6. 2004
    ..This is the first report on the characterization of the KIF7 gene as well as on the identification of KIF727H domain...
  94. ncbi request reprint Comparative genomics on Wnt9a orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 13:989-92. 2005
    ..This is the first report on rat Wnt9a gene as well as on comparative genomics for Wnt9a orthologs...
  95. ncbi request reprint Identification and characterization of rat Desert hedgehog and Indian hedgehog genes in silico
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 26:545-9. 2005
    ..The HPLGMXXXXS motif in the C-terminus was conserved in Shh orthologs and Ihh orthologs, but not in Dhh orthologs...
  96. ncbi request reprint Comparative genomics on SLIT1, SLIT2, and SLIT3 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 14:1351-5. 2005
    ..FOXJ2, E47, ETS1, and FOXA2-binding sites and CCAAT box were conserved among mammalian SLIT3 promoters. Mammalian SLIT1 orthologs were identified as evolutionarily conserved targets of the WNT/beta-catenin signaling pathway...
  97. ncbi request reprint Comparative genomics on HHIP family orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 17:391-5. 2006
    ..Because HHIP1 is the key molecule for vascular remodeling, HHIP1 is the pharmacogenomics target in the fields of oncology and vascular medicine...
  98. ncbi request reprint Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 25:219-23. 2004
    ..This is the first report on human FOXN6, mouse Foxn6, and rat Foxn6 genes...
  99. ncbi request reprint Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway
    Harumi Terasaki
    Laboratory of Molecular Embryology, Graduate School of Science, University of Tokyo, Tokyo 113 0033, Japan
    Int J Mol Med 9:107-12. 2002
    ..These results suggest that up-regulation of FZD10 mRNA in several types of human cells might lead to carcinogenesis through activation of the beta-catenin - TCF signaling pathway synergistically with some class of WNTs...