Shigeaki Kato

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Ligand-induced transrepression by VDR through association of WSTF with acetylated histones
    Ryoji Fujiki
    The Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    EMBO J 24:3881-94. 2005
  2. ncbi Mechanisms of transcriptional repression by 1,25(OH)2 vitamin D
    Shigeaki Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Curr Opin Nephrol Hypertens 16:297-304. 2007
  3. doi Nuclear receptor coregulators merge transcriptional coregulation with epigenetic regulation
    Shigeaki Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Trends Biochem Sci 36:272-81. 2011
  4. ncbi Molecular genetics of vitamin D- dependent hereditary rickets
    Shigeaki Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, and CREST, Japan Science and Technology Corporation, Saitama, Japan
    Horm Res 57:73-8. 2002
  5. ncbi Function of nuclear sex hormone receptors in gene regulation
    Shigeaki Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 0032, Japan
    Cancer Chemother Pharmacol 56:4-9. 2005
  6. ncbi Molecular mechanism of a cross-talk between oestrogen and growth factor signalling pathways
    S Kato
    The Institute of Molecular and Celluar Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Genes Cells 5:593-601. 2000
  7. ncbi The function of vitamin D receptor in vitamin D action
    S Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi cho, Bunkyo ku, Tokyo, 113 0032, Japan
    J Biochem 127:717-22. 2000
  8. ncbi Molecular mechanism of transcriptional control by nuclear vitamin receptors
    S Kato
    The Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Br J Nutr 84:S229-33. 2000
  9. ncbi Function of androgen receptor in gene regulations
    Shigeaki Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Steroid Biochem Mol Biol 89:627-33. 2004
  10. ncbi Vitamin D receptor (VDR) promoter targeting through a novel chromatin remodeling complex
    Shigeaki Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Steroid Biochem Mol Biol 89:173-8. 2004

Collaborators

Detail Information

Publications164 found, 100 shown here

  1. pmc Ligand-induced transrepression by VDR through association of WSTF with acetylated histones
    Ryoji Fujiki
    The Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    EMBO J 24:3881-94. 2005
    ....
  2. ncbi Mechanisms of transcriptional repression by 1,25(OH)2 vitamin D
    Shigeaki Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Curr Opin Nephrol Hypertens 16:297-304. 2007
    ..Unlike its well described positive effects on gene transcription, little is known about how vitamin D induces transcriptional repression...
  3. doi Nuclear receptor coregulators merge transcriptional coregulation with epigenetic regulation
    Shigeaki Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Trends Biochem Sci 36:272-81. 2011
    ....
  4. ncbi Molecular genetics of vitamin D- dependent hereditary rickets
    Shigeaki Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, and CREST, Japan Science and Technology Corporation, Saitama, Japan
    Horm Res 57:73-8. 2002
    ..The phenotypes of the gene KO mice deficient of 1alpha(OH)ase and VDR exhibited the clinical abnormalities observed in the VDDR patients...
  5. ncbi Function of nuclear sex hormone receptors in gene regulation
    Shigeaki Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 0032, Japan
    Cancer Chemother Pharmacol 56:4-9. 2005
    ..Hypersensitivity of AR mutants to antagonists and endogenous steroid hormones may potentiate hormone-dependency in prostate cancer development...
  6. ncbi Molecular mechanism of a cross-talk between oestrogen and growth factor signalling pathways
    S Kato
    The Institute of Molecular and Celluar Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Genes Cells 5:593-601. 2000
    ..In this review, the molecular mechanism of this cross-talk is discussed in terms of the transactivation function of ERs, and their coactivators...
  7. ncbi The function of vitamin D receptor in vitamin D action
    S Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi cho, Bunkyo ku, Tokyo, 113 0032, Japan
    J Biochem 127:717-22. 2000
    ....
  8. ncbi Molecular mechanism of transcriptional control by nuclear vitamin receptors
    S Kato
    The Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Br J Nutr 84:S229-33. 2000
    ..The present study investigating the vitamin D receptor function in gene expression in both cell culture and intact animals was undertaken to better understand the actions of the fat-soluble vitamin A and vitamin D at a molecular level...
  9. ncbi Function of androgen receptor in gene regulations
    Shigeaki Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Steroid Biochem Mol Biol 89:627-33. 2004
    ..When androgen was administered to the flies induced with the polyQ-expanded hAR, their optical nerves were devastated...
  10. ncbi Vitamin D receptor (VDR) promoter targeting through a novel chromatin remodeling complex
    Shigeaki Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Steroid Biochem Mol Biol 89:173-8. 2004
    ..Thus, this study describes a molecular basis of the VDR function on chromosomal DNA through chromatine remodeling...
  11. ncbi Ligand-induced transrepressive function of VDR requires a chromatin remodeling complex, WINAC
    Shigeaki Kato
    The Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Steroid Biochem Mol Biol 103:372-80. 2007
    ....
  12. ncbi [Function of nuclear receptors in bone remodeling and formation]
    Shigeaki Kato
    Tanpakushitsu Kakusan Koso 53:854-62. 2008
  13. doi Targeting Fas/FasL signaling, a new strategy for maintaining bone health
    Yuuki Imai
    The University of Tokyo, Institute of Molecular and Cellular Biosciences, Tokyo, Japan
    Expert Opin Ther Targets 15:1143-5. 2011
    ..However, some concerns still remain, such as the adverse effects of such treatments. From this point of view, a search for novel therapeutic targets, such as Fas signaling, remains important...
  14. ncbi Transcriptional controls by nuclear fat-soluble vitamin receptors through chromatin reorganization
    Shigeaki Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Biosci Biotechnol Biochem 75:410-3. 2011
    ..In this review, these cuttingedge aspects are discussed together with our recent findings on NR co-regulators...
  15. ncbi [Overview: signal transduction and transcriptional controls]
    Shigeaki Kato
    Tanpakushitsu Kakusan Koso 48:2227-32. 2003
  16. ncbi [Transcriptional control by nuclear receptors]
    Shigeaki Kato
    Tanpakushitsu Kakusan Koso 48:2267-74. 2003
  17. pmc Double PHD fingers protein DPF2 recognizes acetylated histones and suppresses the function of estrogen-related receptor alpha through histone deacetylase 1
    Reiko Matsuyama
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 285:18166-76. 2010
    ..These results show that DPF2 acts as a nuclear receptor-selective co-repressor for ERRalpha by associating with both acetylated histone H3 and HDAC1...
  18. pmc Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system
    Yue Zhao
    The Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 0032, Japan
    Mol Cell Biol 29:1017-34. 2009
    ..Thus, our findings suggest that the action of NR coregulators may depend on the state of chromatin at the target loci...
  19. doi Epigenetic silencing of core histone genes by HERS in Drosophila
    Saya Ito
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell 45:494-504. 2012
    ..These findings illustrate a salient molecular switch linking epigenetic gene silencing to cell cycle-dependent histone production...
  20. ncbi An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification
    Hajime Oishi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 281:20-6. 2006
    ..Thus, our results suggested that the multiple BRCA1 functions require a novel hGCN5/TRRAP histone acetyltransferase complex subclass...
  21. ncbi Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts
    Takashi Nakamura
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    Cell 130:811-23. 2007
    ..Our results support a model in which estrogen regulates the life span of mature osteoclasts via the induction of the Fas/FasL system, thereby providing an explanation for the osteoprotective function of estrogen as well as SERMs...
  22. doi A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing
    Yue Zhao
    Laboratory of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell 29:92-101. 2008
    ..Thus, the deubiquitinase activity of the TFTC/STAGA HAT complex is necessary to counteract heterochromatin silencing and acts as a positive cofactor for activation by nuclear receptors in vivo...
  23. pmc Coactivation of estrogen receptor beta by gonadotropin-induced cofactor GIOT-4
    Madoka Kouzu-Fujita
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell Biol 29:83-92. 2009
    ..These findings imply the presence of a novel regulatory convergence between the gonadotropin signaling cascade and ERbeta-mediated transcription in the ovary...
  24. pmc Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity
    Eriko Suzuki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 106:3818-22. 2009
    ..This appears to lead to androgen-dependent onset of SBMA through aberrant E2F transactivation caused by suppressed histone deacetylation...
  25. pmc Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching
    Akiko Murayama
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
    EMBO J 23:1598-608. 2004
    ..Thus, the present study deciphers a novel mechanism of ligand-induced transrepression by nuclear receptor via co-regulator switching...
  26. ncbi The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome
    Hirochika Kitagawa
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, 113 0032, Tokyo, Japan
    Cell 113:905-17. 2003
    ..This suggests that WINAC dysfunction contributes to Williams syndrome, which could therefore be considered, at least in part, a chromatin-remodeling factor disease...
  27. ncbi Repressive domain of unliganded human estrogen receptor alpha associates with Hsc70
    Satoko Ogawa
    The Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Japan
    Genes Cells 10:1095-102. 2005
    ..Thus, these findings suggest that Hsc70 associates with unliganded hERalpha, and thereby deters hERalpha from recruiting transcriptional coregulators, presumably as a component of chaperone complexes...
  28. pmc A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor
    Shun Sawatsubashi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
    Genes Dev 24:159-70. 2010
    ..Thus, the present study suggests that at least one histone chaperone can be categorized as a type of transcriptional coactivator for nuclear receptors...
  29. pmc Switching of chromatin-remodelling complexes for oestrogen receptor-alpha
    Maiko Okada
    The Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    EMBO Rep 9:563-8. 2008
    ..Thus, our results indicate that the transactivation function of ERalpha is cell-cycle dependent and is coupled with a cell-cycle-dependent association of chromatin-remodelling complexes...
  30. ncbi Wnt/beta-catenin and estrogen signaling converge in vivo
    Alexander P Kouzmenko
    The Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 279:40255-8. 2004
    ..Thus, we present here the first direct evidence of cross-talk between Wnt and estrogen signaling pathways via functional interaction between beta-catenin and ERalpha...
  31. ncbi RNA-binding protein hoip accelerates polyQ-induced neurodegeneration in Drosophila
    Takuya Murata
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Biosci Biotechnol Biochem 72:2255-61. 2008
    ..These findings suggest that the process of neurodegeneration induced by abnormal polyQ expansion in the hAR may be regulated by the activity of snoRNP complex...
  32. pmc Phosphorylation of Williams syndrome transcription factor by MAPK induces a switching between two distinct chromatin remodeling complexes
    Hiroyuki Oya
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
    J Biol Chem 284:32472-82. 2009
    ....
  33. ncbi Modulation of oestrogen receptor signalling by association with the activated dioxin receptor
    Fumiaki Ohtake
    The Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 0032, Japan
    Nature 423:545-50. 2003
    ....
  34. doi Vitamin D receptor in osteoblasts is a negative regulator of bone mass control
    Yoko Yamamoto
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, 113 0032, Japan
    Endocrinology 154:1008-20. 2013
    ..These findings establish that VDR in osteoblasts is a negative regulator of bone mass control...
  35. doi Activation of facultatively silenced Drosophila loci associates with increased acetylation of histone H2AvD
    Masahiko Tanabe
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Genes Cells 13:1279-88. 2008
    ..Our data suggest that the N-terminal region of H2AvD plays a pivotal role in transcriptional activation and that induction of transiently silenced Drosophila loci associates with increased acetylation of H2AvD...
  36. pmc Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene
    Mamoru Igarashi
    The Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell Biol 27:7947-54. 2007
    ..Thus, the present study suggests that Msx2 is a target gene for PXR activated by vitamin K and suggests that the osteoprotective action of MK4 in the human mediates, at least in part, a genomic pathway of vitamin K signaling...
  37. ncbi Both N- and C-terminal transactivation functions of DNA-bound ERalpha are blocked by a novel synthetic estrogen ligand
    Yasuji Yamamoto
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
    Biochem Biophys Res Commun 312:656-62. 2003
    ..Therefore, TAS-108 may be effective against tamoxifen-resistant breast cancer via a different mechanism than that for ICI182,780...
  38. ncbi 1alpha,25(OH)2D3-induced DNA methylation suppresses the human CYP27B1 gene
    Mi Sun Kim
    The Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell Endocrinol 265:168-73. 2007
    ..Thus, transcriptional regulation of the CYP27B1 gene appears to be mediated by dual epigenetic modifications...
  39. ncbi In vivo potentiation of human oestrogen receptor alpha by Cdk7-mediated phosphorylation
    Saya Ito
    The Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Genes Cells 9:983-92. 2004
    ..Our findings demonstrate that Cdk7 is involved in regulation of the ligand-induced transactivation function of hERalphain vivo via Ser(118) phosphorylation...
  40. doi Maturation of microRNA is hormonally regulated by a nuclear receptor
    Kaoru Yamagata
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell 36:340-7. 2009
    ..Thus, a steroid hormone achieves posttranscriptional control by regulating the maturation of miRNA...
  41. ncbi Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade
    Miyuki Suzawa
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Cell Biol 5:224-30. 2003
    ....
  42. ncbi Ecdysone receptor-dependent gene regulation mediates histone poly(ADP-ribosyl)ation
    Shun Sawatsubashi
    The Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Biochem Biophys Res Commun 320:268-72. 2004
    ..Our results indicated that EcR-mediated gene regulation may be coupled with chromatin modification through poly(ADP-ribosyl)ation...
  43. ncbi A novel genetic system for analysis of co-activators for the N-terminal transactivation function domain of the human androgen receptor
    Ken ichi Takeyama
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Biosci Biotechnol Biochem 68:1209-15. 2004
    ..Therefore, Drosophila with the hAR AF-1 transgene provides a relevant genetic system in which to uncover novel functions of vertebrate steroid hormone receptors and to screen for novel AF-1 co-regulators...
  44. doi GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis
    Ryoji Fujiki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Nature 459:455-9. 2009
    ..Thus, nuclear MLL5 GlcNAcylation triggers cell lineage determination of HL60 through activation of its HKMT activity...
  45. ncbi The function of nuclear receptors in bone tissues
    Shigeaki Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Bone Miner Metab 21:323-36. 2003
  46. doi Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings
    Fumiaki Ohtake
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Biochem Biophys Res Commun 370:541-6. 2008
    ..Thus, these findings indicate that the cross-talk function of the AhR with sex hormone receptors is an intrinsic function of the AhR...
  47. pmc Testis-specific protein on Y chromosome (TSPY) represses the activity of the androgen receptor in androgen-dependent testicular germ-cell tumors
    Chihiro Akimoto
    The Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 107:19891-6. 2010
    ....
  48. doi Androgen receptor-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells: role of phosphatidylinositol 3-kinase/akt pathway
    Jing Yu
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Endocrinology 151:1822-8. 2010
    ..Activation of PI3-kinase/Akt signaling and the direct interaction of AR with p85alpha are involved, at least in part, in eNOS phosphorylation...
  49. doi CDP/cut is an osteoblastic coactivator of the vitamin D receptor (VDR)
    Eiji Ochiai
    Teijin Institute for Bio Medical Research, Teijin Pharma, Ltd, Tokyo, Japan
    J Bone Miner Res 25:1157-66. 2010
    ..These findings suggest that CDP is a novel differentiation stage-specific coactivator of the VDR in osteoblasts...
  50. ncbi TRRAP as a hepatic coactivator of LXR and FXR function
    Atsushi Unno
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Biochem Biophys Res Commun 327:933-8. 2005
    ..These results suggested that TRRAP plays an important role as a coactivator, presumably part of a complex, in lipid metabolism through regulation of the LXRalpha-mediated gene cascade in hepatic cells...
  51. pmc A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function
    Shinichiro Takezawa
    The Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
    EMBO J 26:764-74. 2007
    ....
  52. ncbi 1Alpha,25(OH)2D3-induced transrepression by vitamin D receptor through E-box-type elements in the human parathyroid hormone gene promoter
    Mi Sun Kim
    The Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    Mol Endocrinol 21:334-42. 2007
    ....
  53. ncbi A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation
    Ichiro Takada
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Cell Biol 9:1273-85. 2007
    ....
  54. doi Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor
    Shuhei Kimura
    The Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Biochem Biophys Res Commun 371:889-93. 2008
    ..These findings suggest that DART1, a histone arginine methyltransferase, is a co-repressor of EcR that is indispensable for normal pupal development in the intact fly...
  55. doi Vitamin E decreases bone mass by stimulating osteoclast fusion
    Koji Fujita
    Department of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan
    Nat Med 18:589-94. 2012
    ..These results show that serum vitamin E is a determinant of bone mass through its regulation of osteoclast fusion...
  56. pmc Transrepressive function of TLX requires the histone demethylase LSD1
    Atsushi Yokoyama
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell Biol 28:3995-4003. 2008
    ..Knockdown of either TLX or LSD1 derepressed expression of the endogenous PTEN gene and inhibited cell proliferation of Y79 cells. Thus, the present study suggests that LSD1 is a prime corepressor for TLX...
  57. ncbi DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs
    Toru Fukuda
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    Nat Cell Biol 9:604-11. 2007
    ..8S rRNA in vitro. Thus, we suggest that DEAD-box RNA helicase subunits are required for recognition of a subset of primary miRNAs in mDrosha-mediated processing...
  58. pmc Brain masculinization requires androgen receptor function
    Takashi Sato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 101:1673-8. 2004
    ..Our results suggested that perinatal brain masculinization requires AR function and that expression of male-typical behaviors in adults is mediated by both AR-dependent and -independent androgen signaling...
  59. pmc Epigenetic regulation of adipogenesis by PHF2 histone demethylase
    Yosuke Okuno
    Laboratory of Epigenetic Skeletal Diseases, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Diabetes 62:1426-34. 2013
    ..These findings suggest that PHF2 histone demethylase potentiates adipogenesis through interaction with CEBPA in vivo. Taken together, PHF2 may be a novel therapeutic target in the treatment of obesity and the metabolic syndrome...
  60. pmc Suppressive function of androgen receptor in bone resorption
    Hirotaka Kawano
    Institute of Molecular and Cellular Biosciences and Department of Orthopedic Surgery, Faculty of Medicine, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 100:9416-21. 2003
    ..Our results indicate that AR function is indispensable for male-type bone formation and remodeling...
  61. ncbi Molecular switching of osteoblastogenesis versus adipogenesis: implications for targeted therapies
    Ichiro Takada
    University of Tokyo, Institute of Molecular and Cellular Biosciences, 1 1 1, Yayoi, Bunkyo ku, Tokyo, 113 0032 Japan
    Expert Opin Ther Targets 13:593-603. 2009
    ..Thus, two signaling cascades promote osteoblastic differentiation from MSC through two distinct modes of PPAR-gamma transrepression...
  62. ncbi Nuclear receptor mediated gene regulation through chromatin remodeling and histone modifications
    Masahiko Kishimoto
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Endocr J 53:157-72. 2006
    ....
  63. pmc Splicing potentiation by growth factor signals via estrogen receptor phosphorylation
    Yoshikazu Masuhiro
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 102:8126-31. 2005
    ....
  64. ncbi Yeast two-hybrid detection systems that are highly sensitive to a certain kind of endocrine disruptors
    Haeng Seog Lee
    Department of Biotechnology, University of Tokyo, Japan
    Biosci Biotechnol Biochem 70:521-4. 2006
    ....
  65. pmc The pituitary function of androgen receptor constitutes a glucocorticoid production circuit
    Junko Miyamoto
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell Biol 27:4807-14. 2007
    ..Thus, this study suggests that the activated AR supports the negative feedback regulation of glucocorticoid production via up-regulation of GR expression in the pituitary gland...
  66. doi Androgen receptor functions in male and female physiology
    Takahiro Matsumoto
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    J Steroid Biochem Mol Biol 109:236-41. 2008
    ..The physiological importance of AR function currently recognized in female reproduction also has been verified in mouse genetic model. Here we review functions of AR in male and female physiology as revealed by mice lacking AR...
  67. doi Ligand-dependent interaction between estrogen receptor alpha and adenomatous polyposis coli
    Alexander P Kouzmenko
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Genes Cells 13:723-30. 2008
    ..Thus, here we present the first evidence of a functional interaction between APC and ER that may be accounted for a tumor protective action of estrogens...
  68. ncbi 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis
    K Takeyama
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113, Japan
    Science 277:1827-30. 1997
    ..These results indicate that the negative feedback regulation of active vitamin D synthesis is mediated by 1alpha(OH)ase through liganded VDR...
  69. ncbi Positive and negative regulations of the renal 25-hydroxyvitamin D3 1alpha-hydroxylase gene by parathyroid hormone, calcitonin, and 1alpha,25(OH)2D3 in intact animals
    A Murayama
    The Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Endocrinology 140:2224-31. 1999
    ..Furthermore, in a moderate state of chronic renal failure, renal cells expressing the 1alpha-hydroxylase gene appear to have diminished potential in response to PTH and calcitonin...
  70. ncbi Nuclear receptor function requires a TFTC-type histone acetyl transferase complex
    Junn Yanagisawa
    Institute of Molecular and Cellular Biosciences, Graduate School of Agricultural and Life Sciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell 9:553-62. 2002
    ..Antisense TRRAP RNA inhibited estrogen-dependent cell growth of breast cancer cells. Thus, the isolated TFTC-type HAT complex acts as a third class of coactivator complex for NR function...
  71. doi [Molecular mechanism of switching adipocyte / osteoblast differentiation through regulation of PPAR-gamma function]
    Ichiro Takada
    The University of Tokyo, Institute of Molecular and Cellular Biosciences, Nuclear Signaling
    Clin Calcium 18:656-61. 2008
    ..Recently, it was found that PPAR-gammainhibits osteoblast differentiation and regulates bone metabolism. In this report, we show recent studies about the extracellular signals regulating the transactivation function of PPAR-gamma...
  72. ncbi The vitamin D3 1alpha-hydroxylase gene and its regulation by active vitamin D3
    Ken ichi Takeyama
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Biosci Biotechnol Biochem 75:208-13. 2011
    ..In this review, we describe switching between positive and negative transcriptional modulation by the VDR, together with recent findings on the mechanisms of VDR-mediated epigenetic regulation in the 1α(OH)ase gene...
  73. ncbi Stimulation of Smad1 transcriptional activity by Ras-extracellular signal-regulated kinase pathway: a possible mechanism for collagen-dependent osteoblastic differentiation
    Miyuki Suzawa
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    J Bone Miner Res 17:240-8. 2002
    ....
  74. ncbi Nuclear receptors as targets for drug development: crosstalk between peroxisome proliferator-activated receptor gamma and cytokines in bone marrow-derived mesenchymal stem cells
    Ichiro Takada
    Institute of Molecular and Cellular Bioscience, University of Tokyo, Japan
    J Pharmacol Sci 97:184-9. 2005
    ....
  75. doi Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis
    Ichiro Takada
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Nat Rev Rheumatol 5:442-7. 2009
    ..This article summarizes Wnt and PPARgamma signaling in MSCs and the crosstalk between these pathways, and speculates on future clinical application of this knowledge as the basis of novel approaches for regeneration therapy...
  76. ncbi Cerebral aneurysms in the elderly in Yamaguchi, Japan. Analysis of the Yamaguchi Data Bank of Cerebral Aneurysm from 1985 to 1995
    K Yamashita
    Department of Neurosurgery, Yamaguchi University School of Medicine, Japan
    Stroke 28:1926-31. 1997
    ..The number of elderly people is markedly increasing in Japan. We have investigated the epidemiology and management outcome of cerebral aneurysms in elderly patients aged > or = 70 years...
  77. ncbi Fgf10 is essential for limb and lung formation
    K Sekine
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Nat Genet 21:138-41. 1999
    ..Thus, we show here that Fgf10 serves as an essential regulator of lung and limb formation...
  78. ncbi Cloning and characterization of kidney-specific promoter of human PTH/PTHrP receptor gene: absence of mutation in patients with pseudohypoparathyroidism type Ib
    S Fukumoto
    Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan
    Mol Cell Endocrinol 141:41-7. 1998
    ..Identification and characterization of nuclear proteins that bind to kidney-specific promoter region of human PTH/PTHrP receptor may be necessary for the elucidation of pathogenesis of PHP type Ib...
  79. ncbi The importance of 25-hydroxyvitamin D3 1 alpha-hydroxylase gene in vitamin D-dependent rickets
    S Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Curr Opin Nephrol Hypertens 7:377-83. 1998
    ....
  80. ncbi Molecular mechanism of a cross-talk between estrogen and growth-factor signaling pathways
    S Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Oncology 55:5-10. 1998
    ..In this review, the molecular mechanism of this cross-talk is discussed...
  81. ncbi Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators
    J Yanagisawa
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Science 283:1317-21. 1999
    ..Thus, Smad3 may mediate cross-talk between vitamin D and TGF-beta signaling pathways...
  82. ncbi Genetic mutation in the human 25-hydroxyvitamin D3 1alpha-hydroxylase gene causes vitamin D-dependent rickets type I
    S Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Mol Cell Endocrinol 156:7-12. 1999
    ..Most importantly in clinical aspects, genetic mutations in this gene to abolish the enzymatic activity are now shown to cause the one of three kinds of hereditary rickets, vitamin D-dependent rickets type I...
  83. doi No occurrence of Pneumocystis jiroveci (carinii) pneumonia in 120 adults undergoing myeloablative unrelated cord blood transplantation
    A Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Transpl Infect Dis 10:303-7. 2008
    ..The results suggest that PCP during the early period after CBT can be effectively prevented by any pre-transplant prophylactic method...
  84. doi Unrelated cord blood transplantation in CML: Japan Cord Blood Bank Network analysis
    T Nagamura-Inoue
    Department of Cell Processing and Transfusion, Research Hospital, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Bone Marrow Transplant 42:241-51. 2008
    ..0004). A pre-transplant European Group for Blood and Marrow Transplantation scoring system was effective in predicting the outcome of UCBT. We conclude that UCBT is a reasonable alternative therapy for patients with CML...
  85. ncbi In vivo function of VDR in gene expression-VDR knock-out mice
    S Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    J Steroid Biochem Mol Biol 69:247-51. 1999
    ..Finally, from the analysis of type I rickets patients, we found missense genetic mutations in 1alpha-hydroxylase, leading to the conclusion that this gene is responsible for the type I rickets...
  86. ncbi FGF-FGFR signaling in vertebrate organogenesis
    S Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Cell Mol Biol (Noisy-le-grand) 45:631-8. 1999
    ..Analyses of the embryos and marker gene expression showed that FGF10 triggers sequential events, which are essential for formations of limb and lung. Focusing on FGF10 function, the FGF-FGFR system is discussed...
  87. doi Unrelated cord blood transplantation after myeloablative conditioning in adults with ALL
    J Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Bone Marrow Transplant 43:455-9. 2009
    ..2%. The 5-year cumulative incidence of TRM and relapse was 3.7 and 27.4%, respectively. These results suggest that unrelated CBT after myeloablative conditioning could be safely and effectively used for adult patients with ALL...
  88. ncbi Analysis of visitation frequency through particle tracking method based on LES and model experiment
    S Kato
    Institute of Industrial Science, University of Tokyo, Japan
    Indoor Air 13:182-93. 2003
    ..In the room model, VF shows a value of 5.70 when the local domain occupies half of the room. It becomes smaller when the size of the local domain is reduced...
  89. ncbi Dietary calcium and phosphorus ratio regulates bone mineralization and turnover in vitamin D receptor knockout mice by affecting intestinal calcium and phosphorus absorption
    Ritsuko Masuyama
    Department of Nutritional Science, Tokyo University of Agriculture, Tokyo, Japan
    J Bone Miner Res 18:1217-26. 2003
    ..High dietary Ca/P ratio promoted bone mineralization and turnover with adequate intestinal Ca and P transports in VDRKO mice...
  90. ncbi Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development
    Yasuo Yanagi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Invest Ophthalmol Vis Sci 43:3489-94. 2002
    ..To clarify the functions of a specific subtype of thyroid hormone receptor (TR), TRbeta2, and photoreceptor cell-specific nuclear receptor (PNR) in the development of cone photoreceptors...
  91. ncbi Employment of the human estrogen receptor beta ligand-binding domain and co-activator SRC1 nuclear receptor-binding domain for the construction of a yeast two-hybrid detection system for endocrine disrupters
    Haeng Seog Lee
    Department of Biotechnology, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Biochem 131:399-405. 2002
    ....
  92. doi [Hormones and osteoporosis update. Androgen and bone remodeling]
    Shigeaki Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Clin Calcium 19:957-62. 2009
    ..However, the molecular basis and target factors underlining its anabolic action are barely known. In this review, the bone phenotypes of ARKO mice generated by us are described...
  93. ncbi Inactivating mutations in the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in patients with pseudovitamin D-deficiency rickets
    S Kitanaka
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    N Engl J Med 338:653-61. 1998
    ....
  94. ncbi The molecular basis of vitamin D-dependent rickets type I
    S Kitanaka
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Endocr J 48:427-32. 2001
    ..In addition, 1alpha-hydroxylase knock-out mice, which is recently generated, would be a useful model animal for VDDR I...
  95. ncbi Stimulation of osteoclast formation by 1,25-dihydroxyvitamin D requires its binding to vitamin D receptor (VDR) in osteoblastic cells: studies using VDR knockout mice
    S Takeda
    Fourth Dept of Internal Medicine, University of Tokyo, Japan
    Endocrinology 140:1005-8. 1999
    ..It is suggested that osteoclastic bone resorption can be maintained without 1,25(OH)2D actions by other stimulatory agents...
  96. ncbi Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning
    T Yoshizawa
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Nat Genet 16:391-6. 1997
    ..These defects, such as alopoecia and uterine hypoplasia, were not observed in vitamin D-deficient animals. The findings establish a critical role for VDR in growth, bone formation and female reproduction in the post-weaning stage...
  97. ncbi Estrogen receptor-mediated cross-talk with growth factor signaling pathways
    S Kato
    The Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-0032, Japan
    Breast Cancer 8:3-9. 2001
    ..Furthermore, we have identified a coactivator that specifically interacts with ER alpha AF-1 (Endoh et al, 1999). In this review, this cross-talk is discussed in terms of the transactivation function of ERs and their coactivators...
  98. pmc Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos
    H Fujii
    Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Japan
    EMBO J 16:4163-73. 1997
    ..These results suggest that P450RA regulates the intracellular level of RA and may be involved in setting up the uneven distribution of active RA in mammalian embryos...
  99. pmc The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice
    Mitsuyasu Iwasawa
    Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Clin Invest 119:3149-59. 2009
    ....
  100. ncbi Study of androgen receptor functions by genetic models
    Takahiro Matsumoto
    Institute of Molecular and Cellular Biosciences, University of Tokyo
    J Biochem 138:105-10. 2005
    ..Here we review recent results of our studies into genetic models of the loss of AR function in mice and the gain of AR function in Drosophila...
  101. ncbi [PPARgamma and bone metabolism]
    Ichiro Takada
    The Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Clin Calcium 14:269-74. 2004
    ..Here, we report the molecular mechanism of PPARgamma transcriptional activity and the suppression of PPARgamma activity by cytokines in bone marrow-derived mesenchymal stem cells...