S Kato

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint The importance of 25-hydroxyvitamin D3 1 alpha-hydroxylase gene in vitamin D-dependent rickets
    S Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Curr Opin Nephrol Hypertens 7:377-83. 1998
  2. ncbi request reprint Genetic mutation in the human 25-hydroxyvitamin D3 1alpha-hydroxylase gene causes vitamin D-dependent rickets type I
    S Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Mol Cell Endocrinol 156:7-12. 1999
  3. ncbi request reprint In vivo function of VDR in gene expression-VDR knock-out mice
    S Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    J Steroid Biochem Mol Biol 69:247-51. 1999
  4. ncbi request reprint FGF-FGFR signaling in vertebrate organogenesis
    S Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Cell Mol Biol (Noisy-le-grand) 45:631-8. 1999
  5. ncbi request reprint Molecular mechanism of a cross-talk between estrogen and growth-factor signaling pathways
    S Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Oncology 55:5-10. 1998
  6. pmc A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA
    M Watanabe
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0033, Japan
    EMBO J 20:1341-52. 2001
  7. ncbi request reprint p300 mediates functional synergism between AF-1 and AF-2 of estrogen receptor alpha and beta by interacting directly with the N-terminal A/B domains
    Y Kobayashi
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan
    J Biol Chem 275:15645-51. 2000
  8. pmc Multifunctional transcription factor TFII-I is an activator of BRCA1 function
    M Tanikawa
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Br J Cancer 104:1349-55. 2011
  9. ncbi request reprint Aberrant growth plate development in VDR/RXR gamma double null mutant mice
    N Yagishita
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Endocrinology 142:5332-41. 2001
  10. ncbi request reprint The tamoxifen-responsive estrogen receptor alpha mutant D351Y shows reduced tamoxifen-dependent interaction with corepressor complexes
    Y Yamamoto
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-0034, Japan
    J Biol Chem 276:42684-91. 2001

Collaborators

Detail Information

Publications122 found, 100 shown here

  1. ncbi request reprint The importance of 25-hydroxyvitamin D3 1 alpha-hydroxylase gene in vitamin D-dependent rickets
    S Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Curr Opin Nephrol Hypertens 7:377-83. 1998
    ....
  2. ncbi request reprint Genetic mutation in the human 25-hydroxyvitamin D3 1alpha-hydroxylase gene causes vitamin D-dependent rickets type I
    S Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Mol Cell Endocrinol 156:7-12. 1999
    ..Most importantly in clinical aspects, genetic mutations in this gene to abolish the enzymatic activity are now shown to cause the one of three kinds of hereditary rickets, vitamin D-dependent rickets type I...
  3. ncbi request reprint In vivo function of VDR in gene expression-VDR knock-out mice
    S Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    J Steroid Biochem Mol Biol 69:247-51. 1999
    ..Finally, from the analysis of type I rickets patients, we found missense genetic mutations in 1alpha-hydroxylase, leading to the conclusion that this gene is responsible for the type I rickets...
  4. ncbi request reprint FGF-FGFR signaling in vertebrate organogenesis
    S Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Cell Mol Biol (Noisy-le-grand) 45:631-8. 1999
    ..Analyses of the embryos and marker gene expression showed that FGF10 triggers sequential events, which are essential for formations of limb and lung. Focusing on FGF10 function, the FGF-FGFR system is discussed...
  5. ncbi request reprint Molecular mechanism of a cross-talk between estrogen and growth-factor signaling pathways
    S Kato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Oncology 55:5-10. 1998
    ..In this review, the molecular mechanism of this cross-talk is discussed...
  6. pmc A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA
    M Watanabe
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0033, Japan
    EMBO J 20:1341-52. 2001
    ..These findings indicate that p72/p68 acts as an ER subtype-selective coactivator through ER alpha AF-1 by associating with the coactivator complex to bind its AF-2 through direct binding with SRA and the SRC-1/TIF2 family proteins...
  7. ncbi request reprint p300 mediates functional synergism between AF-1 and AF-2 of estrogen receptor alpha and beta by interacting directly with the N-terminal A/B domains
    Y Kobayashi
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan
    J Biol Chem 275:15645-51. 2000
    ..Thus, these findings indicate that ligand-induced functional synergism between AF-1 and AF-2 is mediated through p300 by its direct binding to the A/B regions of ERalpha and ERbeta...
  8. pmc Multifunctional transcription factor TFII-I is an activator of BRCA1 function
    M Tanikawa
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Br J Cancer 104:1349-55. 2011
    ....
  9. ncbi request reprint Aberrant growth plate development in VDR/RXR gamma double null mutant mice
    N Yagishita
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Endocrinology 142:5332-41. 2001
    ....
  10. ncbi request reprint The tamoxifen-responsive estrogen receptor alpha mutant D351Y shows reduced tamoxifen-dependent interaction with corepressor complexes
    Y Yamamoto
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-0034, Japan
    J Biol Chem 276:42684-91. 2001
    ..These results may explain the observation that the growth of tumor cells expressing ERalpha(D351Y) can be stimulated by tamoxifen, E2, or both...
  11. ncbi request reprint Diagnostic value of culture, histology and PCR for Helicobacter pylori in the remnant stomach after surgery
    N Matsukura
    Surgery for Organ Function and Biological Regulation First Department of Surgery and Second Department of Pathology, Nippon Medical School, Tokyo, Japan
    Aliment Pharmacol Ther 20:33-8. 2004
    ..Diagnosis of Helicobacter pylori infection in the remnant stomach has not been established...
  12. ncbi request reprint Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators
    J Yanagisawa
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Science 283:1317-21. 1999
    ..Thus, Smad3 may mediate cross-talk between vitamin D and TGF-beta signaling pathways...
  13. ncbi request reprint Sex differences in mucosal response to Helicobacter pylori infection in the stomach and variations in interleukin-8, COX-2 and trefoil factor family 1 gene expression
    S Kato
    Surgery for Organ Function and Biological Regulation, Nippon Medical School, Tama Nagayama Hospital, Tokyo, Japan
    Aliment Pharmacol Ther 20:17-24. 2004
    ....
  14. ncbi request reprint Influence of rapid glycemic control on lens opacity in patients with diabetes mellitus
    S Kato
    Department of Ophthalmology, School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Ophthalmol 130:354-5. 2000
    ..To report the influence of rapid glycemic control on lens opacity in patients with diabetes mellitus...
  15. pmc Anterior capsular contraction after cataract surgery in eyes of diabetic patients
    S Kato
    Department of Ophthalmology, University of Tokyo, School of Medicine, Tokyo, Japan
    Br J Ophthalmol 85:21-3. 2001
    ..To investigate change in the area of anterior capsular opening (ACO) after cataract surgery and its relation to the degree of postoperative anterior inflammation in patients with diabetes mellitus (DM)...
  16. ncbi request reprint Positive and negative regulations of the renal 25-hydroxyvitamin D3 1alpha-hydroxylase gene by parathyroid hormone, calcitonin, and 1alpha,25(OH)2D3 in intact animals
    A Murayama
    The Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Endocrinology 140:2224-31. 1999
    ..Furthermore, in a moderate state of chronic renal failure, renal cells expressing the 1alpha-hydroxylase gene appear to have diminished potential in response to PTH and calcitonin...
  17. ncbi request reprint Genetic differences in interleukin-1 betapolymorphisms among four Asian populations: an analysis of the Asian paradox between H. pylori infection and gastric cancer incidence
    N Matsukura
    First Dept of Surgery, Nippon Medical School, Tokyo, Japan
    J Exp Clin Cancer Res 22:47-55. 2003
    ..IL-1betapolymorphisms were correlated with mucosal atrophy in the Japanese and Chinese populations, but not in the Thai and Vietnamese populations...
  18. ncbi request reprint Positive and negative modulation of vitamin D receptor function by transforming growth factor-beta signaling through smad proteins
    Y Yanagi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0034, Japan
    J Biol Chem 274:12971-4. 1999
    ....
  19. ncbi request reprint Inactivating mutations in the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in patients with pseudovitamin D-deficiency rickets
    S Kitanaka
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    N Engl J Med 338:653-61. 1998
    ....
  20. ncbi request reprint No enzyme activity of 25-hydroxyvitamin D3 1alpha-hydroxylase gene product in pseudovitamin D deficiency rickets, including that with mild clinical manifestation
    S Kitanaka
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    J Clin Endocrinol Metab 84:4111-7. 1999
    ..These results indicate that all of the patients, including those of mild phenotype, are caused by 1alpha-hydroxylase gene mutations that totally abolish the enzyme activity...
  21. doi request reprint Unrelated cord blood transplantation after myeloablative conditioning in adults with ALL
    J Ooi
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Bone Marrow Transplant 43:455-9. 2009
    ..2%. The 5-year cumulative incidence of TRM and relapse was 3.7 and 27.4%, respectively. These results suggest that unrelated CBT after myeloablative conditioning could be safely and effectively used for adult patients with ALL...
  22. ncbi request reprint Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators
    Y Kodera
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
    J Biol Chem 275:33201-4. 2000
    ..Our findings suggest that ligand binding may alter PPARgamma structure in a ligand type-specific way, resulting in distinct PPARgamma-coactivator interactions...
  23. doi request reprint Unrelated cord blood transplantation after myeloablative conditioning in adults with advanced myelodysplastic syndromes
    A Sato
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    Bone Marrow Transplant 46:257-61. 2011
    ..No factor was associated with TRM, relapse and EFS. These results suggest that adult advanced MDS patients without suitable related or unrelated BM donors should be considered as candidates for CBT...
  24. ncbi request reprint 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis
    K Takeyama
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113, Japan
    Science 277:1827-30. 1997
    ..These results indicate that the negative feedback regulation of active vitamin D synthesis is mediated by 1alpha(OH)ase through liganded VDR...
  25. pmc The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor alpha
    O Wada-Hiraike
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1 Bunkyo ku, Tokyo 113 8655, Japan
    Br J Cancer 92:2286-91. 2005
    ..These results suggest that hMSH2 may play an important role as a putative coactivator in ER alpha dependent gene expression...
  26. ncbi request reprint Glycemic control and lens transparency in patients with type 1 diabetes mellitus
    S Kato
    Department of Ophthalmology, School of Medicine, University of Tokyo, 3 28 5 Mejirodai, Bunkyo ku, Tokyo, 112 8688 Japan
    Am J Ophthalmol 131:301-4. 2001
    ..To assess quantitatively the cumulative effect of hyperglycemia on lens transparency in patients with juvenile type 1 diabetes mellitus...
  27. ncbi request reprint The molecular basis of vitamin D-dependent rickets type I
    S Kitanaka
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Endocr J 48:427-32. 2001
    ..In addition, 1alpha-hydroxylase knock-out mice, which is recently generated, would be a useful model animal for VDDR I...
  28. ncbi request reprint Molecular mechanism of a cross-talk between oestrogen and growth factor signalling pathways
    S Kato
    The Institute of Molecular and Celluar Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Genes Cells 5:593-601. 2000
    ..In this review, the molecular mechanism of this cross-talk is discussed in terms of the transactivation function of ERs, and their coactivators...
  29. ncbi request reprint Association of the interleukin-1 beta genetic polymorphism and gastric cancer risk in Japanese
    S Kato
    First Department of Surgery, Nippon Medical School, Tokyo, Japan
    J Gastroenterol 36:696-9. 2001
    ..The -31 C-to-T base transition in the intron of this gene has been reported to be involved in carcinogenic changes within the stomach, especially in H. pylori-infected individuals...
  30. doi request reprint No occurrence of Pneumocystis jiroveci (carinii) pneumonia in 120 adults undergoing myeloablative unrelated cord blood transplantation
    A Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Transpl Infect Dis 10:303-7. 2008
    ..The results suggest that PCP during the early period after CBT can be effectively prevented by any pre-transplant prophylactic method...
  31. ncbi request reprint Chronic ethanol consumption enhances endotoxin induced hepatic sinusoidal leukocyte adhesion
    E Ohki
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Alcohol Clin Exp Res 20:350A-355A. 1996
    ..Leukocyte adhesion to the sinusoidal wall may be associated with increased in tumor necrosis factor-alpha levels...
  32. ncbi request reprint The function of vitamin D receptor in vitamin D action
    S Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi cho, Bunkyo ku, Tokyo, 113 0032, Japan
    J Biochem 127:717-22. 2000
    ....
  33. pmc Identification of DBC1 as a transcriptional repressor for BRCA1
    H Hiraike
    Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo, Japan
    Br J Cancer 102:1061-7. 2010
    ..Hereditary breast and ovarian cancer susceptibility gene product BRCA1, by binding to the promoter region of SIRT1, is a positive regulator of SIRT1 expression...
  34. ncbi request reprint N-terminal activation function is dominant in ligand-dependent transactivation of medaka estrogen receptor alpha in human cells
    Y Mezaki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
    Biochem Biophys Res Commun 289:763-8. 2001
    ..Taken together, our results suggested that meERalpha AF-1 may have a more significant role in estrogen-induced function of meERalpha than AF-2 in medaka fish...
  35. ncbi request reprint Stimulation of osteoclast formation by 1,25-dihydroxyvitamin D requires its binding to vitamin D receptor (VDR) in osteoblastic cells: studies using VDR knockout mice
    S Takeda
    Fourth Dept of Internal Medicine, University of Tokyo, Japan
    Endocrinology 140:1005-8. 1999
    ..It is suggested that osteoclastic bone resorption can be maintained without 1,25(OH)2D actions by other stimulatory agents...
  36. ncbi request reprint Fgf10 is essential for limb and lung formation
    K Sekine
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Nat Genet 21:138-41. 1999
    ..Thus, we show here that Fgf10 serves as an essential regulator of lung and limb formation...
  37. ncbi request reprint Molecular mechanism of transcriptional control by nuclear vitamin receptors
    S Kato
    The Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Br J Nutr 84:S229-33. 2000
    ..The present study investigating the vitamin D receptor function in gene expression in both cell culture and intact animals was undertaken to better understand the actions of the fat-soluble vitamin A and vitamin D at a molecular level...
  38. ncbi request reprint A nuclear matrix-associated factor, SAF-B, interacts with specific isoforms of AUF1/hnRNP D
    Y Arao
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo, 113 0032, Japan
    Arch Biochem Biophys 380:228-36. 2000
    ..Thus, the present study revealed that the isoform-specific functions of AUF1/hnRNP D are defined by intracellular shuttling capacity...
  39. ncbi request reprint Optic disk pallor and retinal atrophy in Sotos syndrome (cerebral gigantism)
    K Inoue
    Department of Ophthalmology, Faculty of Medicine, University of Tokyo Branch Hospital, Tokyo, Japan
    Am J Ophthalmol 130:853-4. 2000
    ..To report a case of Sotos syndrome (cerebral gigantism) with megalophthalmos, optic disk pallor, and retinal atrophy...
  40. pmc Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes
    T Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 108:1001-13. 2001
    ..Our data suggested that appropriate functional antagonism of PPARgamma/RXR may be a logical approach to protection against obesity and related diseases such as type 2 diabetes...
  41. doi request reprint Acute kidney injury after myeloablative cord blood transplantation in adults: the efficacy of strict monitoring of vancomycin serum trough concentrations
    H Mae
    Department of Pharmacy, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    Transpl Infect Dis 15:181-6. 2013
    ..Following these results, we have monitored VCM serum trough concentrations more strictly, to not exceed 10.0 mg/L, since 2008...
  42. ncbi request reprint A case of multiple sclerosis with granulomatous uveitis in Japan--use of the antilipoarabinomannan (LAM)-B test in differential diagnosis
    K Inoue
    Department of Ophthalmology, Branch Hospital, University of Tokyo School of Medicine, Tokyo, Japan
    Am J Ophthalmol 131:524-6. 2001
    ..To report a patient with multiple sclerosis and associated with granulomatous uveitis, and how anti-lipoarabinomannan (LAM)-B antibody can play a key role in differential diagnosis...
  43. ncbi request reprint Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism
    S Kato
    Surgery for Organ Function and Biological Regulation, Nippon Medical School, Tokyo, Japan
    Scand J Gastroenterol 38:886-93. 2003
    ....
  44. ncbi request reprint Effect of subconjunctival steroid injection on intraocular inflammation and blood glucose level after cataract surgery in diabetic patients
    H Fukushima
    Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
    J Cataract Refract Surg 27:1386-91. 2001
    ..To prospectively evaluate the usefulness of a subconjunctival steroid injection given at the completion of cataract surgery in patients with diabetes mellitus...
  45. doi request reprint Allogeneic cord blood transplantation for adult acute lymphoblastic leukemia: retrospective survey involving 256 patients in Japan
    T Matsumura
    Division of Social Communication System, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Leukemia 26:1482-6. 2012
    ..0, 95% CI, 1.2-3.2, P=0.006) and absence of chronic GVHD (hazard ratio 2.4, 95% CI, 1.1-5.1, P=0.02) were negatively associated with OS. CBT is effective for some patients with advanced ALL. It is worth considering for further evaluation...
  46. ncbi request reprint Induction of Fas-mediated apoptosis in a human renal epithelial cell line by interferon-gamma: involvement of Fas-mediated apoptosis in acute renal rejection
    Y Akasaka
    Second Department of Pathology, School of Medicine, Toho University, Tokyo, Japan
    Mod Pathol 11:1107-14. 1998
    ..This suggested that AR might be associated with increased apoptosis in the renal tubular epithelial cells mediated by the Fas/FasL system...
  47. ncbi request reprint Role of endothelin in endotoxin-induced hepatic microvascular dysfunction in rats fed chronically with ethanol
    Y Horie
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Gastroenterol Hepatol 16:916-22. 2001
    ..CONCLUSIONS: These results suggest that endothelin plays a role in the LPS-induced hepatic microcirculatory disturbance, especially in alcohol-fed animals...
  48. ncbi request reprint Phylogenetic diversity of phytopathogenic mycoplasmalike organisms
    S Namba
    Faculty of Agriculture, University of Tokyo, Japan
    Int J Syst Bacteriol 43:461-7. 1993
    ....
  49. doi request reprint Pyrazinamide resistance in multidrug-resistant Mycobacterium tuberculosis isolates in Japan
    H Ando
    Department of Infectious Diseases, Research Institute, International Medical Centre of Japan, Shinjuku, Tokyo, Japan
    Clin Microbiol Infect 16:1164-8. 2010
    ..Among the pncA mutations, 11 had not been previously reported. The results of the LiPA were fully consistent with the DNA sequencing results. A majority of MDR M. tuberculosis isolates in Japan were resistant to pyrazinamide...
  50. pmc Cyclin E as a coactivator of the androgen receptor
    A Yamamoto
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113, Japan
    J Cell Biol 150:873-80. 2000
    ..These results suggest that cyclin E functions as a coactivator of the AR, and that aberrant expression of cyclin E in tumors may contribute to persistent activation of AR function, even during androgen ablation therapy...
  51. ncbi request reprint Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning
    T Yoshizawa
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Nat Genet 16:391-6. 1997
    ..These defects, such as alopoecia and uterine hypoplasia, were not observed in vitamin D-deficient animals. The findings establish a critical role for VDR in growth, bone formation and female reproduction in the post-weaning stage...
  52. doi request reprint Combinatory effects of androgen receptor deficiency and hind limb unloading on bone
    Y Saita
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Chiyoda ku, Tokyo, Japan
    Horm Metab Res 41:822-8. 2009
    ..These data suggest that combination of androgen receptor deficiency and hind limb unloading results in exacerbation of disuse-induced osteopenia due to the enhanced levels of bone resorption...
  53. ncbi request reprint Secondary closure of neodymium:YAG laser posterior capsulotomy
    T Oshika
    Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
    J Cataract Refract Surg 27:1695-7. 2001
    ..Although IOL exchange surgery was considered, a second Nd:YAG laser intervention successfully removed the proliferated lens materials and restored the visual acuity. The glistenings were not the cause of the reduced vision...
  54. ncbi request reprint p300/CBP acts as a coactivator of the cone-rod homeobox transcription factor
    Y Yanagi
    Department of Ophthalmology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Biochem Biophys Res Commun 269:410-4. 2000
    ..The C-terminal domain of CRX was mapped as a transactivation domain to associate with p300/CBP. Taken together, our results demonstrate that p300/CBP acts as one of the coactivators of CRX...
  55. ncbi request reprint [A clinical perspective, a frontiers of PPAR function]
    M Suzawa
    Institute of Molecular and Cellular Biosciences, University of Tokyo
    Nippon Rinsho 59:2269-77. 2001
    ..Here we present the latest developments in the PPAR field, with particular emphasis on the physiological function of PPARs during various nutritional states, and the possible role of PPARs in several chronic disease...
  56. ncbi request reprint Ocular and systemic factors relevant to diabetic keratoepitheliopathy
    K Inoue
    Department of Ophthalmology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Cornea 20:798-801. 2001
    ..This study examines the contribution of ocular and systemic factors to diabetic keratoepitheliopathy...
  57. ncbi request reprint Role of gut cryptopatches in early extrathymic maturation of intestinal intraepithelial T cells
    T Oida
    Department of Microbiology, Keio University School of Medicine, Tokyo, Japan
    J Immunol 164:3616-26. 2000
    ..These findings underscore the role of gut CP in the early extrathymic maturation of CD8alphaalpha+ IEL, including cell-surface expression of alphaEbeta7 integrin, CD3epsilon gene transcription, and TCR gene rearrangements...
  58. doi request reprint Changes in the contents of enzymatic immature, mature, and non-enzymatic senescent cross-links of collagen after once-weekly treatment with human parathyroid hormone (1-34) for 18 months contribute to improvement of bone strength in ovariectomized monkeys
    M Saito
    Department of Orthopaedic Surgery, Jikei University School of Medicine, 3 25 8, Nishi Shinbashi, Minato ku, Tokyo, 105 8461, Japan
    Osteoporos Int 22:2373-83. 2011
    ....
  59. ncbi request reprint Electron microscopic DOPA reaction test for oculocutaneous albinism
    Y Takizawa
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Arch Dermatol Res 292:301-5. 2000
    ....
  60. pmc A heterozygous mutation of beta-actin associated with neutrophil dysfunction and recurrent infection
    H Nunoi
    Institute of Medical Science, University of Tokyo, Minatoku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 96:8693-8. 1999
    ..Heterozygous expression of mutant beta-actin in neutrophils and other cells of this patient may act in a dominant-negative fashion to adversely affect cellular activities dependent on the function of nonmuscle actin...
  61. doi request reprint Unrelated cord blood transplantation in CML: Japan Cord Blood Bank Network analysis
    T Nagamura-Inoue
    Department of Cell Processing and Transfusion, Research Hospital, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Bone Marrow Transplant 42:241-51. 2008
    ..0004). A pre-transplant European Group for Blood and Marrow Transplantation scoring system was effective in predicting the outcome of UCBT. We conclude that UCBT is a reasonable alternative therapy for patients with CML...
  62. ncbi request reprint Analysis of visitation frequency through particle tracking method based on LES and model experiment
    S Kato
    Institute of Industrial Science, University of Tokyo, Japan
    Indoor Air 13:182-93. 2003
    ..In the room model, VF shows a value of 5.70 when the local domain occupies half of the room. It becomes smaller when the size of the local domain is reduced...
  63. ncbi request reprint Cerebral aneurysms in the elderly in Yamaguchi, Japan. Analysis of the Yamaguchi Data Bank of Cerebral Aneurysm from 1985 to 1995
    K Yamashita
    Department of Neurosurgery, Yamaguchi University School of Medicine, Japan
    Stroke 28:1926-31. 1997
    ..The number of elderly people is markedly increasing in Japan. We have investigated the epidemiology and management outcome of cerebral aneurysms in elderly patients aged > or = 70 years...
  64. ncbi request reprint Cloning and characterization of kidney-specific promoter of human PTH/PTHrP receptor gene: absence of mutation in patients with pseudohypoparathyroidism type Ib
    S Fukumoto
    Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan
    Mol Cell Endocrinol 141:41-7. 1998
    ..Identification and characterization of nuclear proteins that bind to kidney-specific promoter region of human PTH/PTHrP receptor may be necessary for the elucidation of pathogenesis of PHP type Ib...
  65. ncbi request reprint A high frequency of defective vif genes in peripheral blood mononuclear cells from HIV type 1-infected individuals
    K Tominaga
    Department of Microbiology, Keio University School of Medicine, Tokyo, Japan
    AIDS Res Hum Retroviruses 12:1543-9. 1996
    ..Phylogenetic analysis revealed that the vif sequences from each individual were clustered into a separate group and that all of them belong to subtype B...
  66. doi request reprint Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli
    A P Kouzmenko
    Department of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Oncogene 27:4888-99. 2008
    ..Our data suggest that APC involves in the DSB DNA repair and that truncation mutations impair chromatin-associated functions of APC...
  67. ncbi request reprint Rapid detection and typing of oculopathogenic strain of subgenus D adenoviruses by fiber-based PCR and restriction enzyme analysis
    A K Adhikary
    Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Japan
    Invest Ophthalmol Vis Sci 42:2010-5. 2001
    ..This all-in-1-day detection and typing method will be quite useful to the rapid diagnosis of subgenus D adenovirus infection...
  68. ncbi request reprint Factors associated with declining numbers of chronic tuberculosis excretors in Japan
    H Hoshino
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Tokyo, Japan
    Int J Tuberc Lung Dis 15:169-73, i. 2011
    ..Japan's National Tuberculosis Programme (NTP)...
  69. ncbi request reprint Estrogen receptor-mediated cross-talk with growth factor signaling pathways
    S Kato
    The Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-0032, Japan
    Breast Cancer 8:3-9. 2001
    ..Furthermore, we have identified a coactivator that specifically interacts with ER alpha AF-1 (Endoh et al, 1999). In this review, this cross-talk is discussed in terms of the transactivation function of ERs and their coactivators...
  70. ncbi request reprint Neuropathological analysis in spinal muscular atrophy type II
    S Araki
    Department of Neuropediatrics, Tokyo Metropolitan Neurological Hospital, 2 6 1 Musashi dai, Fuchu shi, 183 0042, Tokyo, Japan
    Acta Neuropathol 106:441-8. 2003
    ..These data suggest that oxidative stress and, to a lesser extent, apoptotic cell death, but not disturbed neurofilament metabolism or excitotoxicity, may be involved in neurodegeneration in SMA type II...
  71. ncbi request reprint Detection of the Na(+)-translocating NADH-quinone reductase in marine bacteria using a PCR technique
    S Kato
    New Energy and Industrial Technology Development Organization NEDO, Marine Biotechnology Institute Co, Ltd, Tokyo, Japan
    Can J Microbiol 46:325-32. 2000
    ..The nucleotide and predicted amino acid sequences of nqr6 were highly conserved among the PCR-positive marine bacteria. A phylogenetic analysis of marine bacteria, based on nqr6 sequencing, was performed...
  72. ncbi request reprint Id2 gene-targeted crosstalk between Wnt and retinoid signaling regulates proliferation in human keratinocytes
    A Memezawa
    Department of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Oncogene 26:5038-45. 2007
    ....
  73. ncbi request reprint Primary omental gamma/delta T-cell lymphoma involving the central nervous system
    Y Harada
    The Third Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Leuk Lymphoma 45:1947-50. 2004
    ..High dose methotrexate (HD-MTX) chemotherapy successfully eliminated the omental tumor and reduced the size of the intracranial masses, thus HD-MTX appears to be an effective treatment against GDTL...
  74. doi request reprint Cardiovascular toxicity of cryopreserved cord blood cell infusion
    T Konuma
    Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Bone Marrow Transplant 41:861-5. 2008
    ..These data suggest that infusion of cryopreserved CB without further manipulation after thawing is safe and well tolerated. However, cardiovascular toxicities including hypertension and bradycardia were frequently observed...
  75. ncbi request reprint Diagnosis of Japanese patients with HHH syndrome by molecular genetic analysis: a common mutation, R179X
    T Miyamoto
    Department of Inherited Metabolic Disease, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    J Hum Genet 46:260-2. 2001
    ....
  76. pmc Nucleotide sequence of a new YPT1-related human cDNA which belongs to the ras gene superfamily
    K Tachibana
    Department of Microbiology, Keio University School of Medicine, Tokyo, Japan
    Nucleic Acids Res 16:10368. 1988
  77. ncbi request reprint Modeling and CFD prediction for diffusion and adsorption within room with various adsorption isotherms
    S Murakami
    Department of System Design Engineering, Keio University, 4 1 1 Hiyoshi, Kohoku Ku, Yokohama, Kanagawa 223 8821, Japan
    Indoor Air 13:20-7. 2003
    ..The results of numerical prediction show that the physical models and their numerical simulations explain well the mechanism of the transportation of VOCs in a room...
  78. ncbi request reprint Cross-talk between Msx/Dlx homeobox genes and vitamin D during tooth mineralization
    F Lezot
    Laboratoire de Biologie Orofaciale et Pathologie INSERM EMI 0110, Université Paris 7 EA2380, IFR 58 Institut des Cordeliers, rue de l Ecole de Medecine, 75006 Paris, France
    Connect Tissue Res 43:509-14. 2002
    ..Finally, in the same cells, such combinations appeared to modulate VDR expression outlining the existence of complex cross-regulations between vitamin D and Msx/Dix pathways...
  79. ncbi request reprint Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
    A Bhushan
    INSERM 457, Hospital Robert Debre, 75019 Paris, France
    Development 128:5109-17. 2001
    ..These results indicate that Fgf10 signalling is required for the normal development of the pancreas and should prove useful in devising methods to expand pancreatic progenitor cells...
  80. ncbi request reprint Metabolism of 1alpha,25-dihydroxyvitamin D(3) in vitamin D receptor-ablated mice in vivo
    B Endres
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Biochemistry 39:2123-9. 2000
    ..The presence of 25-hydroxyvitamin D(3)-24-hydroxylase mRNA in the kidneys of these vitamin D receptor null mutant mice was confirmed by ribonuclease protection assay...
  81. ncbi request reprint Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads
    K Kinuta
    Department of Pediatrics, Okayama University Medical School, Japan
    Endocrinology 141:1317-24. 2000
    ..The action of vitamin D on estrogen biosynthesis was partially explained by maintaining calcium homeostasis; however, direct regulation of the expression of the aromatase gene should not be neglected...
  82. ncbi request reprint In vitro and in vivo analysis of the immune system of vitamin D receptor knockout mice
    C Mathieu
    Laboratory of Experimental Medicine and Endocrinology, LEGENDO, Catholic University of Leuven, Belgium
    J Bone Miner Res 16:2057-65. 2001
    ..This study proves that although 1,25(OH)2D3 is a pharmacologic and probably a physiological immunomodulator, its immune function is redundant. Moreover, we confirm the essential role of calcium in the immune system...
  83. pmc Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects
    S J Van Cromphaut
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, B 3000 Belgium
    Proc Natl Acad Sci U S A 98:13324-9. 2001
    ....
  84. ncbi request reprint Characterization of a vitamin D receptor knockout mouse as a model of colorectal hyperproliferation and DNA damage
    E Kallay
    Department of Pathophysiology, University of Vienna Medical School, Vienna, Ludwig Boltzmann Institute for Aging Research, Vienna, Austria
    Carcinogenesis 22:1429-35. 2001
    ....
  85. ncbi request reprint Vitamin D 1alpha-hydroxylase knockout mice as a hereditary rickets animal model
    S Kato
    Endocrinology 142:2734-5. 2001
  86. ncbi request reprint Dietary phosphorus restriction reverses the impaired bone mineralization in vitamin D receptor knockout mice
    R Masuyama
    Department of Nutritional Science, Tokyo University of Agriculture, Japan
    Endocrinology 142:494-7. 2001
    ....
  87. ncbi request reprint 3D-CFD analysis of diffusion and emission of VOCs in a FLEC cavity
    Q Zhu
    China Academy of Building Research, Beijing, China
    Indoor Air 17:178-88. 2007
    ..That is, when the testing material surface in the cavity is partially sealed to decrease the Loading Factor, the emission rate become higher with the decrease in the exposed area of the testing material...
  88. ncbi request reprint FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development
    H Ohuchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, 46 29 Yoshida shimo adachi cho, Sakyo ku, Kyoto City, Kyoto, 606 8501, Japan
    Biochem Biophys Res Commun 277:643-9. 2000
    ..These results suggest that FGF10 acts as a major ligand for FGFR2b in mouse multi-organ development...
  89. ncbi request reprint Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene
    K Suzuki
    Center for Animal Resources and Development, Kumamoto University, Japan
    FEBS Lett 481:53-6. 2000
    ..These data suggest that Fgf10 is required for embryonic epidermal morphogenesis but is not essential for hair follicle development...
  90. ncbi request reprint Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation
    R Haraguchi
    Center for Animal Resources and Development CARD, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Development 127:2471-9. 2000
    ..These results suggest that the FGF system is a key element in orchestrating GT development...
  91. ncbi request reprint Cloning and sequencing of the gene encoding the mouse vitamin D receptor
    Y Kamei
    Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan
    Gene 152:281-2. 1995
    ..Comparison of the amino-acid sequence to that of humans and rats revealed high homology in the DNA- and ligand-binding domains. Divergence appeared in the internal region between the two domains...
  92. ncbi request reprint Monocarboxylate transporter 1 gene expression in the ovine gastrointestinal tract
    D Kirat
    Department of Veterinary Physiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Vet J 171:462-7. 2006
    ....
  93. ncbi request reprint cDNA cloning and regional distribution of a novel member of the opioid receptor family
    K Fukuda
    Department of Anesthesia, Kyoto University Hospital, Japan
    FEBS Lett 343:42-6. 1994
    ..RNA blot hybridization and in situ hybridization analysis revealed that ROR-C mRNA is expressed in discrete regions of the rat central nervous system...
  94. pmc Sequence of the cDNA encoding the laminin B1 chain reveals a multidomain protein containing cysteine-rich repeats
    M Sasaki
    Proc Natl Acad Sci U S A 84:935-9. 1987
    ..Part of the cysteine-rich region is homologous to epidermal growth factor and other proteins that contain epidermal growth factor-like repeats...
  95. doi request reprint Blood eosinophilia after unrelated cord blood transplantation for adults
    A Tomonari
    Bone Marrow Transplant 42:63-5. 2008
  96. ncbi request reprint Establishment and characterization of a human B cell line from the lung tissue of a patient with scleroderma; extraordinary high level of IL-6 secretion by stimulated fibroblasts
    K Kondo
    Second Department of Surgery, Aichi Medical University, Nagakute, Aichi, 480-1195, Japan
    Cytokine 13:220-6. 2001
    ..Thus, abnormally augmented B cell proliferation and the inflammatory response stimulated by these cells may cause the fibrotic changes in patients with progressive systemic sclerosis...
  97. ncbi request reprint Molecular cloning and expression of mouse mg(2+)-dependent protein phosphatase beta-4 (type 2C beta-4)
    S Kato
    Department of Biochemistry, Tohoku University, Sendai, Japan
    Arch Biochem Biophys 318:387-93. 1995
    ..These results suggest that the complex structure of MPP beta isoforms and their tissue- and developmental stage-specific expression reflect the variety of their physiological functions...
  98. ncbi request reprint Identification of a vitamin D-responsive element in the 5'-flanking region of the rat 25-hydroxyvitamin D3 24-hydroxylase gene
    Y Ohyama
    Graduate Department of Gene Science, Faculty of Science, Hiroshima University, Japan
    J Biol Chem 269:10545-50. 1994
    ....
  99. ncbi request reprint Human glyoxalase I. cDNA cloning, expression, and sequence similarity to glyoxalase I from Pseudomonas putida
    N S Kim
    Kanagawa Academy of Science and Technology KAST, Japan
    J Biol Chem 268:11217-21. 1993
    ..The amino acid sequence of human glyoxalase I exhibited 57% identity with Pseudomonas putida glyoxalase I at the C-terminal two-thirds, suggesting that the two enzymes may have originated from a common ancestor...
  100. ncbi request reprint Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product
    T Yamaguchi
    Sagami Chemical Research Center, Kanagawa
    J Biochem 120:494-97. 1996
    ..These results suggest that the obtained cDNA encodes a novel human E2 which may be involved in protein degradation mainly in the muscles and testis...
  101. ncbi request reprint Okadaic acid suppresses neural differentiation-dependent expression of the neurofilament-L gene in P19 embryonal carcinoma cells by post-transcriptional modification
    Y Sasahara
    Department of Biochemistry, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980, Japan
    J Biol Chem 271:25950-7. 1996
    ....