A Kato

Summary

Affiliation: University of Toyama
Country: Japan

Publications

  1. ncbi request reprint Biological properties of D- and L-1-deoxyazasugars
    Atsushi Kato
    Department of Hospital Pharmacy, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    J Med Chem 48:2036-44. 2005
  2. doi request reprint Iminosugars from Baphia nitida Lodd
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan
    Phytochemistry 69:1261-5. 2008
  3. ncbi request reprint Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan Electronic address
    Bioorg Med Chem 22:2435-41. 2014
  4. ncbi request reprint Synthesis and biological evaluation of N-(2-fluorophenyl)-2β-deoxyfuconojirimycin acetamide as a potent inhibitor for α-l-fucosidases
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan Electronic address
    Bioorg Med Chem 21:6565-73. 2013
  5. doi request reprint Protective effects of dietary 1,5-anhydro-D-glucitol as a blood glucose regulator in diabetes and metabolic syndrome
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama, Japan
    J Agric Food Chem 61:611-7. 2013
  6. doi request reprint α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan
    J Med Chem 55:10347-62. 2012
  7. ncbi request reprint Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity
    A Kato
    Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Phytomedicine 16:258-61. 2009
  8. doi request reprint Structure-activity relationships of flavonoids as potential inhibitors of glycogen phosphorylase
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan
    J Agric Food Chem 56:4469-73. 2008
  9. doi request reprint 2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan
    Bioorg Med Chem 18:3790-4. 2010
  10. doi request reprint Protective effects of dietary chamomile tea on diabetic complications
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan
    J Agric Food Chem 56:8206-11. 2008

Collaborators

  • Robert J Nash
  • N Asano
  • Noriko Kato
  • Yasuhiro Minami
  • Yuji Matsuya
  • Kenji Sugimoto
  • Ken ichi Hosoya
  • Naoki Toyooka
  • Shuichi Hirono
  • F Sanae
  • Hideo Nemoto
  • P Compain
  • M Morishita
  • Kenji Matsumoto
  • Y Mizushina
  • O R Martin
  • H Takahata
  • Masaru Miyazaki
  • Hiroaki Shimizu
  • Hiroyuki Yoshidome
  • Fumio Kimura
  • Masayuki Ohtsuka
  • Hiroshi Ito
  • Kyoko Ikeda
  • Isao Adachi
  • Akira Togawa
  • Yumi Nishiyama
  • Momoyo Ichimaru
  • Chiaki Ohara
  • Yuichi Yoshimura
  • Satoshi Ambiru
  • Francis D Juma
  • Simon G Mathenge
  • Masataka Moriyasu
  • Mitsue Haraguchi
  • Tatsushi Imahori
  • Chinami Kuriyama
  • Tadaomi Fukada
  • Hideyuki Yoshitomi
  • Linhua Jin
  • Mahito Nakanishi
  • Liang Yu
  • Hironobu Makino
  • Takahiro Goto
  • Shigeo Fujita
  • Patrick B Chalo Mutiso
  • Jean Yves Goujon
  • Kinuko Iwasa
  • Tsukasa Takayashiki
  • Dan Takeuchi
  • Yasuhito Shimizu
  • Mamoru Hasegawa
  • Russell J Molyneux
  • Kayo Yasuda
  • Yasuhiro Ikeda
  • Ryouko Takahashi
  • Yukako Saito
  • Ogusa Kamiyama
  • Tadashi Okamoto
  • Saori Miyauchi
  • Tatsunori Miyagawa
  • Katsunori Furukawa
  • Satoshi Nozawa
  • Tsukasa Takayasiki
  • Ken Nishimura
  • Jun Okabe
  • Kozo Takayama
  • Akiko Eguchi
  • Shigeaki Sawada
  • Yoshifumi Inoue
  • Kazunori Kataoka
  • Toshinori Ito
  • Hikaru Matsuda
  • Jumpei Ehara
  • Yoko Tabe
  • Atsushi Harada
  • Guillaume Godin
  • Katsunori Sasaki
  • Naoko Ogiwara
  • David Gueyrard
  • Noboru Mitsuhashi
  • Noriyoshi Nakatani
  • Joseph N Nganga
  • Yasuhiro Morita
  • Tomoko Takahashi
  • Yoshiaki Shimizu
  • Alison A Watson
  • Silvana L Gorniak
  • Yukihiko Kameda
  • Masayuki Fukumura

Detail Information

Publications48

  1. ncbi request reprint Biological properties of D- and L-1-deoxyazasugars
    Atsushi Kato
    Department of Hospital Pharmacy, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    J Med Chem 48:2036-44. 2005
    ..On the other hand, although l-allo-DNJ is a moderate inhibitor of alpha-mannosidase (IC(50) = 64 microM), it may become a key compound for the drug design of potential therapeutic agents for alpha-mannosidosis...
  2. doi request reprint Iminosugars from Baphia nitida Lodd
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan
    Phytochemistry 69:1261-5. 2008
    ....
  3. ncbi request reprint Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan Electronic address
    Bioorg Med Chem 22:2435-41. 2014
    ....
  4. ncbi request reprint Synthesis and biological evaluation of N-(2-fluorophenyl)-2β-deoxyfuconojirimycin acetamide as a potent inhibitor for α-l-fucosidases
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan Electronic address
    Bioorg Med Chem 21:6565-73. 2013
    ..We therefore expect that this compound may find applications in new therapeutic trials against genetic deficiency disorders. ..
  5. doi request reprint Protective effects of dietary 1,5-anhydro-D-glucitol as a blood glucose regulator in diabetes and metabolic syndrome
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama, Japan
    J Agric Food Chem 61:611-7. 2013
    ..1,5-AG therefore represents a new class of promising functional sweeteners, where the daily consumption of 1,5-AG with meals could inhibit the progress of hyperglycemia and metabolic syndrome...
  6. doi request reprint α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan
    J Med Chem 55:10347-62. 2012
    ..It is noteworthy that the effective dose was about 10-fold lower than that for miglitol. α-1-C-Butyl-LAB therefore represents a new class of promising compounds that can improve postprandial hyperglycemia...
  7. ncbi request reprint Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity
    A Kato
    Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Phytomedicine 16:258-61. 2009
    ..Furthermore, rhetsinine inhibited sorbitol accumulation by 79.3% at 100 microM. These results suggested that the E. rutaecarpa derived component, rhetsinine, would be potentially useful in the treatment of diabetic complications...
  8. doi request reprint Structure-activity relationships of flavonoids as potential inhibitors of glycogen phosphorylase
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan
    J Agric Food Chem 56:4469-73. 2008
    ..2 and 68.7 microM, respectively. These results suggested that as a group of novel GP inhibitors, flavonoids have potential to contribute to the protection or improvement of control of diabetes type II...
  9. doi request reprint 2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan
    Bioorg Med Chem 18:3790-4. 2010
    ....
  10. doi request reprint Protective effects of dietary chamomile tea on diabetic complications
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan
    J Agric Food Chem 56:8206-11. 2008
    ..These results clearly suggested that daily consumption of chamomile tea with meals could contribute to the prevention of the progress of hyperglycemia and diabetic complications...
  11. doi request reprint 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan
    Bioorg Med Chem Lett 20:5630-3. 2010
    ..Furthermore, compound 15 clearly suppressed galactitol accumulation in a dose-dependent manner. These results provide an insight into the structural requirements of coumarins for developing a new-type of selective ALR2 inhibitor...
  12. doi request reprint Docking and SAR studies of D- and L-isofagomine isomers as human β-glucocerebrosidase inhibitors
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan
    Bioorg Med Chem 19:3558-68. 2011
    ..These results provide an insight into the structural requirements of isofagomine isomers for developing a new type of pharmacological chaperone for Gaucher disease...
  13. ncbi request reprint Inhibitory effects of Zingiber officinale Roscoe derived components on aldose reductase activity in vitro and in vivo
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan
    J Agric Food Chem 54:6640-4. 2006
    ..These results suggested that it would contribute to the protection against or improvement of diabetic complications for a dietary supplement of ginger or its extract containing aldose reductase inhibitors...
  14. ncbi request reprint Isolation of glycosidase-inhibiting hyacinthacines and related alkaloids from Scilla socialis
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan
    J Nat Prod 70:993-7. 2007
    ..Alkaloids 13 and 14 were shown to be inhibitory toward mammalian alpha-glucosidase (IC50 = 45 and 77 microM, respectively), and alkaloid 14 was demonstrated as a moderate inhibitor of bacterial beta-glucosidase (IC50 = 48 microM)...
  15. ncbi request reprint Evaluation of amino acid-mustard transport as L-type amino acid transporter 1 (LAT1)-mediated alkylating agents
    Ken ichi Hosoya
    Department of Pharmaceutics, University of Toyama, Toyama, Japan
    Biol Pharm Bull 31:2126-30. 2008
    ..These findings suggest that phenylglycine-mustard is a better substrate for LAT1 than melphalan and other amino acid-mustards...
  16. ncbi request reprint Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae)
    Mitsue Haraguchi
    Animal Health Center, Biological Institute of Sao Paulo, Sao Paulo, Brazil
    J Agric Food Chem 51:4995-5000. 2003
    ..02 microM), alkaloid 2, which has been thought to be an intermediate in the biosynthesis of 1, was also a potent inhibitor of alpha-mannosidase with an IC(50) value of 4.6 microM...
  17. doi request reprint In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures
    Chinami Kuriyama
    Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3 Kanagawa machi, Kanazawa 920 1181, Japan
    Bioorg Med Chem 16:7330-6. 2008
    ..6-fold at 500 microM...
  18. doi request reprint Synthesis of both enantiomers of hydroxypipecolic acid derivatives equivalent to 5-azapyranuronic acids and evaluation of their inhibitory activities against glycosidases
    Yuichi Yoshimura
    Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4 4 1, Komatsushima, Aoba ku, Miyagi, Sendai 981 8558, Japan
    Bioorg Med Chem 16:8273-86. 2008
    ..In addition, it is interesting that some uronic-type azasugar derivatives showed moderate inhibitory activities against beta-N-acetylglucosaminidase...
  19. doi request reprint Synthesis of all stereoisomers of 3-hydroxypipecolic acid and 3-hydroxy-4,5-dehydropipecolic acid and their evaluation as glycosidase inhibitors
    Chiaki Ohara
    Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, Sendai 981 8558, Japan
    Bioorg Med Chem Lett 18:1810-3. 2008
    ..Screening of these molecules for glycosidase inhibition has been examined. Compound 3 was shown to be a potent inhibitor of beta-N-acetylglucosaminidase as well as Escherichia coli beta-glucuronidase...
  20. ncbi request reprint New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii
    Kayo Yasuda
    Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3 Kanagawa machi, Kanazawa 920 1181, Japan
    J Nat Prod 65:198-202. 2002
    ....
  21. ncbi request reprint Thermodynamic properties of BPTI variants with highly simplified amino acid sequences
    Atsushi Kato
    Department of Biotechnology and Life Sciences, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2 24 16 Nakamachi, Koganei Shi, Tokyo 184 8588, Japan
    J Mol Biol 372:737-46. 2007
    ..Overall, we conclude that a thermodynamic native state can be achieved by proteins encoded with extensively simplified sequences...
  22. doi request reprint Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases
    Yasuhiro Minami
    Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3 Kanagawa machi, Kanazawa 920 1181, Japan
    Bioorg Med Chem 16:2734-40. 2008
    ..34 microM). This indicates that the sulfate in the side chain plays an important role in the specificity of enzyme inhibition...
  23. ncbi request reprint Asymmetric synthesis of the four possible fagomine isomers
    Hiroki Takahata
    Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, Sendai 981 8558, Japan
    J Org Chem 68:3603-7. 2003
    ..The synthesis involved the construction of the piperidene-type chiral building block 5 followed by dihydroxylation, starting from the d-serine-derived Garner aldehyde 6...
  24. ncbi request reprint The inhibitory action of pyrrolidine alkaloid, 1,4-dideoxy-1,4-imino-D-ribitol, on eukaryotic DNA polymerases
    Yoshiyuki Mizushina
    Department of Nutritional Science, Laboratory of Food and Nutritional Sciences, Kobe Gakuin University, Nishi ku, Kobe, 651 2180, Hyogo, Japan
    Biochem Biophys Res Commun 304:78-85. 2003
    ..The relationship between the structure of DRB and the inhibition of eukaryotic DNA polymerases is discussed...
  25. ncbi request reprint Mechanisms of hypothermic protection against ischemic liver injury in mice
    Atsushi Kato
    Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Am J Physiol Gastrointest Liver Physiol 282:G608-16. 2002
    ..These data suggest that hypothermia suppresses the hepatic inflammatory response through selective inhibition of JNK and AP-1...
  26. pmc Specific role of interleukin-1 in hepatic neutrophil recruitment after ischemia/reperfusion
    Atsushi Kato
    Department of Surgery, University of Cincinnati College of Medicine, Ohio 45267, USA
    Am J Pathol 161:1797-803. 2002
    ..These data suggest that IL-1 functions to augment neutrophil accumulation, but does not play an essential role in this response...
  27. ncbi request reprint Promotion of hepatic ischemia/reperfusion injury by IL-12 is independent of STAT4
    Atsushi Kato
    Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Transplantation 73:1142-5. 2002
    ..IL-12 mediates its effects through the transcription factor, signal transducer and activator of transcription-4 (STAT4). Therefore, we investigated the response to hepatic ischemia/reperfusion in STAT4-deficient mice...
  28. pmc The amino-terminal half of Sendai virus C protein is not responsible for either counteracting the antiviral action of interferons or down-regulating viral RNA synthesis
    Atsushi Kato
    Department of Viral Diseases and Vaccine Control, National Institute of Infectious Diseases, Musashi Murayama, Tokyo 208 0011, Japan
    J Virol 76:7114-24. 2002
    ..These data indicated that the activities of the C protein to counteract the antiviral action of IFNs and to down-regulate viral RNA synthesis were not encoded within a region of at least 98 amino acids in its amino-terminal half...
  29. ncbi request reprint Endogenous IL-13 protects hepatocytes and vascular endothelial cells during ischemia/reperfusion injury
    Atsushi Kato
    Department of Surgery, Division of Trauma and Critical Care, University of Cincinnati College of Medicine, OH 45267, USA
    Hepatology 37:304-12. 2003
    ..In contrast, endogenous IL-13 appears to be critical for the control of this response, with prominent protective effects on hepatocytes and hepatic endothelial cells...
  30. ncbi request reprint Recombinant Sendai virus-mediated gene transfer into adult rat retinal tissue: efficient gene transfer by brief exposure
    Yasuhiro Ikeda
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Exp Eye Res 75:39-48. 2002
    ..This work represents the first report of SeV-mediated gene transfer to ocular tissue, and identifies recombinant SeV as a new tool for studies of retinal gene transfer and gene therapy...
  31. ncbi request reprint Anterior transhepatic approach for hepatocellular carcinoma located in deep positions of segment VIII
    Tadaomi Fukada
    Department of General Surgery, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Hepatogastroenterology 54:536-8. 2007
    ..This anterior transhepatic approach provides a wide operating field and easy hemostasis, and could preserve the liver parenchyma as much as possible in a patient with liver dysfunction...
  32. ncbi request reprint Alkaloids from the poisonous plant Ipomoea carnea: effects on intracellular lysosomal glycosidase activities in human lymphoblast cultures
    Kyoko Ikeda
    Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3 Kanagawa machi, Kanazawa 920 1181, Japan
    J Agric Food Chem 51:7642-6. 2003
    ..The lysosomal beta-glucosidase inhibitory calystegines seem to have little risk of inducing intoxication of livestock...
  33. ncbi request reprint Lipopolysaccharide-binding protein critically regulates lipopolysaccharide-induced IFN-beta signaling pathway in human monocytes
    Atsushi Kato
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    J Immunol 172:6185-94. 2004
    ..This critical role for LBP implies the presence of possible mechanisms linking LBP to the intracellular signaling between Toll-like receptor 4 and IRF-3, leading to the induction of IFN-beta by LPS...
  34. ncbi request reprint Increased expression of toll-like receptor 4 enhances endotoxin-induced hepatic failure in partially hepatectomized mice
    Tsukasa Takayashiki
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana Chuo ku, Chiba, 260 0856 Japan
    J Hepatol 41:621-8. 2004
    ..It has recently been reported that toll-like receptor 4 (TLR4) is involved in recognizing lipopolysaccharides (LPS). The aim of this study was to investigate the role of TLR4 in endotoxin-induced liver injury after hepatectomy...
  35. ncbi request reprint Should the extrahepatic bile duct be resected for locally advanced gallbladder cancer?
    Yasuhito Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba 560 8670, Japan
    Surgery 136:1012-7; discussion 1018. 2004
    ..The incidence and mode of spread of carcinoma of the gallbladder into the hepatoduodenal ligament have not been well described pathologically for gallbladder carcinoma extending into the subserosa and beyond...
  36. ncbi request reprint General synthesis and biological evaluation of alpha-1-C-substituted derivatives of fagomine (2-deoxynojirimycin-alpha-C-glycosides)
    Jean Yves Goujon
    Institut de Chimie Organique et Analytique, CNRS, Universite d Orleans, rue de Chartres, BP 6759, 45067 Orleans, France
    Bioorg Med Chem 13:2313-24. 2005
    ..The glycosyl phosphate mimetic 15k was found to display no inhibitory activity towards glycogen phosphorylase b and phosphoglucomutase...
  37. ncbi request reprint Interleukin 18 causes hepatic ischemia/reperfusion injury by suppressing anti-inflammatory cytokine expression in mice
    Dan Takeuchi
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana Chuo ku, Chiba 260 0856, Japan
    Hepatology 39:699-710. 2004
    ..In conclusion, the data suggest that IL-18 is required for facilitating neutrophil-dependent hepatic ischemia/reperfusion injury through suppressing anti-inflammatory cytokine expression...
  38. ncbi request reprint Novel mucosal insulin delivery systems based on fusogenic liposomes
    Takahiro Goto
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa, Tokyo 142 8501, Japan
    Pharm Res 23:384-91. 2006
    ..The objective of this study was to evaluate the potential of FL to improve the mucosal absorption of insulin from rat intestinal membranes...
  39. ncbi request reprint Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats
    Hiroaki Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    World J Gastroenterol 11:7254-60. 2005
    ..To study the regulatory mechanisms of sinusoidal regeneration after partial hepatectomy...
  40. ncbi request reprint Changes in growth factor and cytokine expression in biliary obstructed rat liver and their relationship with delayed liver regeneration after partial hepatectomy
    Hironobu Makino
    Department of General Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 0856, Japan
    World J Gastroenterol 12:2053-9. 2006
    ..To study the effects of obstructive jaundice on liver regeneration after partial hepatectomy...
  41. ncbi request reprint Sendai virus-mediated gene delivery into hepatocytes via isolated hepatic perfusion
    Shigeo Fujita
    Department of Surgery, E1, Osaka University Graduate School of Medicine, Japan
    Biol Pharm Bull 29:1728-34. 2006
    ..Furthermore, expression of the marker genes was undetectable in nonhepatic tissues, including the gonads, indicating that this approach strictly targets hepatic tissues and thus offers good clinical potential for human gene therapy...
  42. ncbi request reprint Alpha-1-C-octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease
    Liang Yu
    Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3 Kanagawa machi, Kanazawa 920 1181, Japan
    Bioorg Med Chem 14:7736-44. 2006
    ..3-fold at 20 microM. These experimental results suggest that CO-DNJ is a significant pharmacological chaperone for N370S Gaucher variants, minimizing the potential for undesirable side effects such as alpha-Glu inhibition...
  43. ncbi request reprint Cytotoxic C-benzylated dihydrochalcones from Uvaria acuminata
    Momoyo Ichimaru
    Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    Chem Pharm Bull (Tokyo) 52:138-41. 2004
    ..The structural elucidation of compounds 1 and 2 in spectroscopic studies is described. C-Benzylated dihydrochalcones, especially 1, 2, 4, and 6, showed considerable cytotoxicity toward human promyelocytic leukemia HL-60 cells...
  44. ncbi request reprint Mutational analysis of protein solubility enhancement using short peptide tags
    Atsushi Kato
    Department of Biotechnology and Life Sciences, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2 24 16 Nakamachi, Koganei Shi, Tokyo 184 8588, Japan
    Biopolymers 85:12-8. 2007
    ..Furthermore, tagged samples remained soluble for over ten days, as observed by their HSQC spectra. We believe that lysine- and arginine-based SEP-tags may provide an effective and versatile method for enhancing protein solubility...
  45. ncbi request reprint Secondary and tertiary isoquinoline alkaloids from Xylopia parviflora
    Yumi Nishiyama
    Natural Medicinal Chemistry, Kobe Pharmaceutical University, 4 19 1, Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    Phytochemistry 67:2671-5. 2006
    ..Their structures were determined on the basis of analysis of spectroscopic data...
  46. ncbi request reprint [The anti-tumoral effect of PI3K inhibitor and MEK inhibitor combined with STI571 on chronic myeloid leukemia cells in a bone marrow stromal cell co-culture system]
    Linhua Jin
    Department of Clinical Pathology, Juntendo University School of Medicine
    Rinsho Ketsueki 47:1364-71. 2006
    ..These results provide a rationale for multi-molecular target therapy approaches based on a combination of signal transduction inhibitors with STI571 in CML...
  47. ncbi request reprint Combined vascular resection in operative resection for hilar cholangiocarcinoma: does it work or not?
    Masaru Miyazaki
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Surgery 141:581-8. 2007
    ..Our aim was to evaluate implications of combined vascular resection in patients with hilar cholangiocarcinoma by analyzing the outcomes of all patients who underwent operative resection...
  48. ncbi request reprint Quaternary isoquinoline alkaloids from Xylopia parviflora
    Yumi Nishiyama
    Natural Medicinal Chemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    Phytochemistry 65:939-44. 2004
    ..3,4-Dihydro-6,7-dimethoxy-2-methyl-isoquinolinium and N-methylpurpuerine were isolated as natural products for the first time. Their structures were determined on the basis of spectroscopic evidence...