Research Topics
| K KataokaSummaryAffiliation: University of Tokyo Country: Japan Publications
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Detail Information
Publications
Block copolymer micelles for drug delivery: design, characterization and biological significanceK Kataoka
Department of Materials Science, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
Adv Drug Deliv Rev 47:113-31. 2001..As an important perspective on carrier systems based on polymeric micelles, their feasibility as non-viral gene vectors is also summarized in this review article...
Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasisMd Rafi
Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Control Release 159:189-96. 2012..These results suggest DACHPt-loaded micelles as a promising nanocarrier for the treatment of scirrhous gastric cancers and their lymphatic metastases...- Cisplatin-loaded polymer-metal complex micelle with time-modulated decaying property as a novel drug delivery systemN Nishiyama
Department of Materials Science, Graduate School of Engineering, University of Tokyo, Japan
Pharm Res 18:1035-41. 2001..Thus, CDDP-loaded micelles are expected to be a novel formulation of CDDP for clinical use... - Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesionsH Kagaya
Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Gene Ther 19:61-9. 2012..These findings suggest that introduction of cRGD to polyplex micelles might create novel and useful functions for gene transfer and contribute to the establishment of efficient gene therapy for vascular diseases... - Preparation and characterization of size-controlled polymeric micelle containing cis-dichlorodiammineplatinum(II) in the coreN Nishiyama
Department of Materials Science, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
J Control Release 74:83-94. 2001..These CDDP-loaded micelles are expected to have potential utility in tumor-directed delivery system of CDDP through the modulated in vivo biodisposition based on the EPR effect... - Delivering the code: polyplex carriers for deoxyribonucleic acid and ribonucleic acid interference therapiesR James Christie
Department of Materials Engineering, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
Endocrinology 151:466-73. 2010..The most promising designs comprise features to help increase stability in circulation and also contain functionality to aid in endosome escape of nucleic acid cargo after cellular internalization... - Sugar-installed block copolymer micelles: their preparation and specific interaction with lectin moleculesY Nagasaki
Department of Materials Science, Science University of Tokyo, Noda 278-8510, Japan
Biomacromolecules 2:1067-70. 2001..With a lectin-immobilized affinity column, the cluster effect of the sugar molecule on the micelle surface was clearly observed... - Long-circulating poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles with modulated surface chargeY Yamamoto
Department of Materials Science, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
J Control Release 77:27-38. 2001.... - Glutathione-sensitive stabilization of block copolymer micelles composed of antisense DNA and thiolated poly(ethylene glycol)-block-poly(L-lysine): a potential carrier for systemic delivery of antisense DNAY Kakizawa
Department of Materials Science, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
Biomacromolecules 2:491-7. 2001..On the other hand, the micelles dissociated to release ODN in the presence of GSH at a concentration comparable to the intracellular environment, featuring the potential ability of this system for intracellular ODN delivery... - Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formationD Akagi
Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Gene Ther 14:1029-38. 2007..These findings suggest that the PEG-b-P[Asp(DET)] polyplex micelle may have promising potential as a nonviral vector for the treatment of vascular diseases... - Pronounced activity of enzymes through the incorporation into the core of polyion complex micelles made from charged block copolymersA Harada
Department of Materials Science, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
J Control Release 72:85-91. 2001..This type of PIC micelle system entrapping enzyme in the core might be useful for the design of diagnostic as well as targetable therapeutic systems of enzyme including antibody-directed enzyme prodrug therapy (ADEPT)... - Novel ternary polyplex of triblock copolymer, pDNA and anionic dendrimer phthalocyanine for photochemical enhancement of transgene expressionA Arnida
Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan
J Control Release 116:e75-7. 2006 - Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on sizeH Cabral
Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Hongo, Bunkyo ku, Japan
Nat Nanotechnol 6:815-23. 2011..We also showed that the penetration and efficacy of the larger micelles could be enhanced by using a transforming growth factor-β inhibitor to increase the permeability of the tumours... - Physicochemical properties and nuclease resistance of antisense-oligodeoxynucleotides entrapped in the core of polyion complex micelles composed of poly(ethylene glycol)-poly(L-lysine) block copolymersA Harada
Department of Materials Science, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Tokyo, Japan
Eur J Pharm Sci 13:35-42. 2001..These characteristics of the PIC micelle system highlight its promising feature as ODN carrier used in the field of targeting therapy... - Quantitative and reversible lectin-induced association of gold nanoparticles modified with alpha-lactosyl-omega-mercapto-poly(ethylene glycol)H Otsuka
Department of Materials Science, Graduate School of Engineering, The University of Tokyo, Hongo 7-3-1, Tokyo 113-8656, Japan
J Am Chem Soc 123:8226-30. 2001..This simple, yet highly effective, derivatization of gold nanoparticles with heterobifunctional PEG provides a convenient method to construct various colloidal sensor systems currently applied in bioassays and biorecognition... - Significant enhancement of antitumor activity and bioavailability of intracellular pH-sensitive polymeric micelles by folate conjugationY Bae
Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan
J Control Release 116:e49-50. 2006 - Ligand-installed PEGylated bionanosphereY Nagasaki
Department of Materials Science, Tokyo University of Science, Noda 278 8510, Japan
IEE Proc Nanobiotechnol 152:89-96. 2005..This FRET system using the PEGylated CdS QD coupled with fluorescent-labelled protein can be utilised as a highly sensitive bioanalytical system... - Polyion complex micelles as vectors in gene therapy--pharmacokinetics and in vivo gene transferM Harada-Shiba
National Cardiovascular Center Research Institute, Osaka, Japan
Gene Ther 9:407-14. 2002..When the PIC micelles were injected via supramesenteric vein, expression of the gene was observed only in the liver and was sustained for 3 days. It was suggested that this gene delivery system is intrinsically efficient... - Cisplatin-incorporated polymeric micelles eliminate nephrotoxicity, while maintaining antitumor activityY Mizumura
Department of Medicine, National Cancer Center Hospital, Chuo-ku, Tokyo 104-0045, Japan
Jpn J Cancer Res 92:328-36. 2001..CDDP / m treatment caused much less renal damage than CDDP. These results indicate that CDDP / m treatment can reduce CDDP-induced nephrotoxicity without compromising the anticancer cytotoxicity of CDDP... - Survivin inhibits apoptosis in cytotrophoblastsA Shiozaki
Department of Obstetrics and Gynecology, Health Insurance Takaoka Hospital, Japan
Placenta 24:65-76. 2003..These findings suggest that survivin antagonizes apoptosis in cytotrophoblasts, extravillous trophoblasts, and choriocarcinoma cells... - Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteinsK Igarashi
Department of Biochemistry, Tohoku University School of Medicine, Sendai, Japan
Nature 367:568-72. 1994.... - Two new members of the maf oncogene family, mafK and mafF, encode nuclear b-Zip proteins lacking putative trans-activator domainK T Fujiwara
Department of Viral Oncology, Cancer Institute, Tokyo, Japan
Oncogene 8:2371-80. 1993..Tissue distributions of these three maf-family genes are different from one another, probably reflecting their different functions in vivo... - A carcinoembryonic antigen family cDNA from mouse placenta encoding a protein with a rare domain compositionK Kataoka
Department of Biochemistry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama shi, 930 0194, Japan
Placenta 21:610-4. 2000..Except for in the placenta, Ceacam11 transcripts were not detected in any adult tissues examined, including brain, lung, glandular stomach, small intestine, colon, liver, kidney and testis... - Metastatic brain tumor surgery using fluorescein sodium: technical noteT Okuda
Department of Neurosurgery, Kinki University School of Medicine, Osaka, Japan
Minim Invasive Neurosurg 50:382-4. 2007..Fluorescein sodium is inexpensive, highly safe, and comparatively easy to use, and does not require any special equipment. We believe that the use of fluorescein sodium is beneficial for resection of the metastatic brain tumor... - A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activitiesK Kataoka
Department of Virology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku 108 8639, Tokyo, Japan
J Biol Chem 276:819-26. 2001..These results suggested that the interaction of a set of Hox proteins with Maf family members may interfere not only with their oncogenicity but also with their physiological roles... - Cloning of the hamster androgen receptor geneK Shiba
Department of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan
J Dermatol Sci 26:163-8. 2001..Availability of the recombinant hamAR clone along with the flank organ system should provide a more powerful tool than currently available to investigate androgen action at the molecular level... 
Octaarginine-modified multifunctional envelope-type nanoparticles for gene deliveryI A Khalil
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan
Gene Ther 14:682-9. 2007..These data demonstrate that MEND is a promising non-viral gene delivery system that may provide superior results to existing non-viral gene delivery technologies...- Prevention of abdominal aortic aneurysms by simultaneous inhibition of NFkappaB and ets using chimeric decoy oligonucleotides in a rabbit modelT Miyake
Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan
Gene Ther 13:695-704. 2006..Further modification of chimeric decoy ODN would be useful to treat AAA as a decoy-based therapy... - Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in ratsH Uchino
Investigative Treatment Division, National Cancer Center Research Institute East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
Br J Cancer 93:678-87. 2005.... - Novel collagen sponge reinforced with polyglycolic acid fiber produces robust, normal hair in murine hair reconstitution modelM Itoh
Department of Tissue Regeneration, Research Institute, International Medical Center of Japan, Tokyo, Japan
Tissue Eng 10:818-24. 2004..These data suggested the usefulness of PGA fiber-containing collagen sponges for hair reconstitution in research and clinical applications... - Activation of the phosphatidylinositol-3' kinase pathway and DNA synthesis by a mutant insulin-like growth factor I receptor lacking the NPXY motifK Kataoka
Molecular Diagnosis and Therapeutics, Department of Oral Restitution, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
J Endocrinol 181:139-46. 2004..These results indicate that the IGF-IR is able to activate the PI3-K pathway and induce DNA synthesis in a normal fashion without the NPXY motif when the receptor is fully activated... - Differentially expressed Maf family transcription factors, c-Maf and MafA, activate glucagon and insulin gene expression in pancreatic islet alpha- and beta-cellsK Kataoka
Laboratory of Molecular and Developmental Biology, Graduate School of Biological Science, Nara Institute of Science and Technology, 8916 5 Takayama cho, Ikoma 630 0192, Japan
J Mol Endocrinol 32:9-20. 2004..Thus, c-Maf and MafA are differentially expressed in alpha- and beta-cells where they regulate glucagon and insulin gene expression, respectively... - MafB, a new Maf family transcription activator that can associate with Maf and Fos but not with JunK Kataoka
Department of Viral Oncology, Cancer Institute, Tokyo, Japan
Mol Cell Biol 14:7581-91. 1994..Through formation of numerous bZip dimers, the Maf family proteins along with the AP-1 components should provide great diversity in transcriptional regulation for a wide variety of genes...