Kiyoto Kasai

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Differences in evoked potential characteristics between DRPLA patients and patients with progressive myoclonic epilepsy: preliminary findings indicating usefulness for differential diagnosis
    K Kasai
    Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Japan
    Epilepsy Res 37:3-11. 1999
  2. ncbi request reprint Delayed automatic detection of change in speech sounds in adults with autism: a magnetoencephalographic study
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655 Tokyo, Japan
    Clin Neurophysiol 116:1655-64. 2005
  3. ncbi request reprint Impaired cortical network for preattentive detection of change in speech sounds in schizophrenia: a high-resolution event-related potential study
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Japan
    Am J Psychiatry 159:546-53. 2002
  4. ncbi request reprint Neuroanatomy and neurophysiology in schizophrenia
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Neurosci Res 43:93-110. 2002
  5. pmc Comprehensive early intervention for patients with first-episode psychosis in Japan (J-CAP): study protocol for a randomised controlled trial
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, 113 8655, Japan
    Trials 12:156. 2011
  6. doi request reprint Structural disruption of the dorsal cingulum bundle is associated with impaired Stroop performance in patients with schizophrenia
    Kunio Takei
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 114:119-27. 2009
  7. ncbi request reprint Association between lower P300 amplitude and smaller anterior cingulate cortex volume in patients with posttraumatic stress disorder: a study of victims of Tokyo subway sarin attack
    Tsuyoshi Araki
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Neuroimage 25:43-50. 2005
  8. ncbi request reprint Decreased prefrontal activation during letter fluency task in adults with pervasive developmental disorders: a near-infrared spectroscopy study
    Hitoshi Kuwabara
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Behav Brain Res 172:272-7. 2006
  9. doi request reprint Association between sigma-1 receptor gene polymorphism and prefrontal hemodynamic response induced by cognitive activation in schizophrenia
    Ryu Takizawa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:491-8. 2009
  10. doi request reprint Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism
    Tetsuya Marui
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int J Neuropsychopharmacol 12:1-10. 2009

Detail Information

Publications72

  1. ncbi request reprint Differences in evoked potential characteristics between DRPLA patients and patients with progressive myoclonic epilepsy: preliminary findings indicating usefulness for differential diagnosis
    K Kasai
    Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Japan
    Epilepsy Res 37:3-11. 1999
    ..Thus, evoked potential measurements may be useful to differentiate DRPLA patients from those with progressive myoclonic epilepsy...
  2. ncbi request reprint Delayed automatic detection of change in speech sounds in adults with autism: a magnetoencephalographic study
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655 Tokyo, Japan
    Clin Neurophysiol 116:1655-64. 2005
    ..e. automatic change detection of speech and non-speech sounds, using magnetoencephalographic recording of mismatch response elicited by change in vowels and tones...
  3. ncbi request reprint Impaired cortical network for preattentive detection of change in speech sounds in schizophrenia: a high-resolution event-related potential study
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Japan
    Am J Psychiatry 159:546-53. 2002
    ..The goal in this study was to obtain an electrophysiological index of preattentive detection of change in speech sounds by schizophrenic patients...
  4. ncbi request reprint Neuroanatomy and neurophysiology in schizophrenia
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Neurosci Res 43:93-110. 2002
    ..Finally, we addressed the issue of the heterogeneity of schizophrenia from the neurobiological perspective, in relation to the neuroanatomical and neurophysiological measures...
  5. pmc Comprehensive early intervention for patients with first-episode psychosis in Japan (J-CAP): study protocol for a randomised controlled trial
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, 113 8655, Japan
    Trials 12:156. 2011
    ..The purpose of this trial is to investigate the effectiveness and affordability of 18-month comprehensive early intervention services for patients with first-episode psychosis compared with typical treatment...
  6. doi request reprint Structural disruption of the dorsal cingulum bundle is associated with impaired Stroop performance in patients with schizophrenia
    Kunio Takei
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 114:119-27. 2009
    ....
  7. ncbi request reprint Association between lower P300 amplitude and smaller anterior cingulate cortex volume in patients with posttraumatic stress disorder: a study of victims of Tokyo subway sarin attack
    Tsuyoshi Araki
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Neuroimage 25:43-50. 2005
    ..These results provide the first evidence that electrophysiological deficits of controlled attention observed in patients with PTSD may be linked to underlying brain morphological abnormalities...
  8. ncbi request reprint Decreased prefrontal activation during letter fluency task in adults with pervasive developmental disorders: a near-infrared spectroscopy study
    Hitoshi Kuwabara
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Behav Brain Res 172:272-7. 2006
    ..The present results may be also potentially useful for applying NIRS to clinical settings of child psychiatry...
  9. doi request reprint Association between sigma-1 receptor gene polymorphism and prefrontal hemodynamic response induced by cognitive activation in schizophrenia
    Ryu Takizawa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:491-8. 2009
    ..Our findings also suggest that the prefrontal hemodynamic response assessed by noninvasive and less demanding NIRS is a useful intermediate phenotype for translational research in schizophrenia...
  10. doi request reprint Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism
    Tetsuya Marui
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int J Neuropsychopharmacol 12:1-10. 2009
    ..Considering the important role of the NRCAM gene in brain development, our results therefore indicated that the NRCAM gene is one of the strong candidate genes for autism...
  11. doi request reprint Tract-specific analysis of white matter integrity disruption in schizophrenia
    Natsuko Kunimatsu
    Department of Diagnostic Radiology, Toranomon Hospital, 2 2 2 Toranomon, Minato ku, Tokyo, Japan
    Psychiatry Res 201:136-43. 2012
    ..Our DTI study showed that the integrity of white matter is disrupted in patients with schizophrenia. The results of our sub-analyses suggest that changes in FA and ADC may be related to negative symptom scores or illness duration...
  12. doi request reprint Disrupted integrity of the fornix is associated with impaired memory organization in schizophrenia
    Kunio Takei
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 103:52-61. 2008
    ..We investigated an association between DTI abnormalities of the fornix and impairment of memory organization in schizophrenia...
  13. ncbi request reprint Localized volume reduction in prefrontal, temporolimbic, and paralimbic regions in schizophrenia: an MRI parcellation study
    Hidenori Yamasue
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 8655, Japan
    Psychiatry Res 131:195-207. 2004
    ..These findings indicate the importance of ACG abnormalities in the pathophysiology of schizophrenia...
  14. doi request reprint Association between the oxytocin receptor gene and amygdalar volume in healthy adults
    Hideyuki Inoue
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Biol Psychiatry 68:1066-72. 2010
    ..Genetic studies have revealed a link between the OXTR gene and the susceptibility to autism spectrum disorders (ASD), especially in the social dysfunctional feature of ASD...
  15. ncbi request reprint Reduced frontopolar activation during verbal fluency task in schizophrenia: a multi-channel near-infrared spectroscopy study
    Ryu Takizawa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Schizophr Res 99:250-62. 2008
    ....
  16. ncbi request reprint Phonetic mismatch negativity predicts social skills acquisition in schizophrenia
    Yuki Kawakubo
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Psychiatry Res 152:261-5. 2007
    ..Although preliminary, these results suggest that phonetic MMN could be an index of social skills acquisition in patients with schizophrenia...
  17. doi request reprint Effect of tryptophan hydroxylase-2 gene variants on amygdalar and hippocampal volumes
    Hideyuki Inoue
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Brain Res 1331:51-7. 2010
    ..These results suggest that amygdalar and hippocampal volumes assessed using MRI may be a useful intermediate phenotype that will uncover the biological pathway linking 5-HT synthesis and emotional behaviors and affective disorders...
  18. doi request reprint Cortical thickness, gray matter volume, and white matter anisotropy and diffusivity in schizophrenia
    Mizuho Murakami
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neuroradiology 53:859-66. 2011
    ..The study was conducted to evaluate simultaneously gray matter changes and white matter changes in patients with schizophrenia...
  19. ncbi request reprint Increased positive thought disorder with illness duration in patients with schizophrenia
    Keiko Maeda
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Psychiatry Clin Neurosci 61:687-90. 2007
    ..TDI scores were not associated with verbal memory or executive functioning. These results indicate an ongoing worsening of positive thought disorder through the course of illness in schizophrenia...
  20. ncbi request reprint Multiple-time replicability of near-infrared spectroscopy recording during prefrontal activation task in healthy men
    Toshiaki Kono
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Res 57:504-12. 2007
    ..Further studies using different conditions or assessing sensitivity to longitudinal changes following interventions are necessary...
  21. ncbi request reprint Sex dimorphism in gray/white matter volume and diffusion tensor during normal aging
    Osamu Abe
    Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    NMR Biomed 23:446-58. 2010
    ..Our results provide strong evidence of sex dimorphism in global and focal diffusion characteristics during normal aging...
  22. ncbi request reprint Volume reduction and altered sulco-gyral pattern of the orbitofrontal cortex in first-episode schizophrenia
    Yoichiro Takayanagi
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 121:55-65. 2010
    ..In addition, it remains elusive whether the OFC morphology in first-episode patients is related to their clinical features...
  23. ncbi request reprint Differential spatiotemporal characteristics of the prefrontal hemodynamic response and their association with functional impairment in schizophrenia and major depression
    Masaru Kinou
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 150:459-67. 2013
    ..These results suggest a differential brain pathophysiology between SZ and MDD. Future large-scale studies are needed to determine the practical applicability of these findings for clinical diagnosis and evaluation. ..
  24. doi request reprint Volume reductions in frontopolar and left perisylvian cortices in methamphetamine induced psychosis
    Yuta Aoki
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 147:355-61. 2013
    ....
  25. doi request reprint The influence of gender and personality traits on individual difference in auditory mismatch: a magnetoencephalographic (MMNm) study
    Junko Matsubayashi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Brain Res 1236:159-65. 2008
    ..Our observation may provide useful information to establish MMN/MMNm as a clinical tool for monitoring auditory cortical function on an individual basis...
  26. doi request reprint Association between autism and variants in the wingless-type MMTV integration site family member 2 ( WNT2) gene
    Tetsuya Marui
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int J Neuropsychopharmacol 13:443-9. 2010
    ..Considering the important role of the WNT2 gene in brain development, our results therefore indicate that the WNT2 gene is one of the strong candidate genes for autism...
  27. doi request reprint Voxel-based analyses of gray/white matter volume and diffusion tensor data in major depression
    Osamu Abe
    Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Psychiatry Res 181:64-70. 2010
    ..These results suggest that the frontolimbic neural circuit might play an important role in the neuropathology of patients with major depressive disorder...
  28. doi request reprint Different hemodynamic response patterns in the prefrontal cortical sub-regions according to the clinical stages of psychosis
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 132:54-61. 2011
    ..Multichannel near-infrared spectroscopy (NIRS), which can easily and noninvasively measure hemodynamics over the prefrontal cortex, is a candidate instrument for clinical use...
  29. pmc Impaired prefrontal hemodynamic maturation in autism and unaffected siblings
    Yuki Kawakubo
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    PLoS ONE 4:e6881. 2009
    ..Moreover, to clarify the genetic influences on developmental changes in the prefrontal dysfunction in ASD, unaffected siblings of the ASD participants were also assessed...
  30. ncbi request reprint Voxel-based diffusion tensor analysis reveals aberrant anterior cingulum integrity in posttraumatic stress disorder due to terrorism
    Osamu Abe
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Psychiatry Res 146:231-42. 2006
    ..The present study demonstrated further evidence of abnormalities of both the ACC, a structure that is pivotally involved in attention, emotional regulation, and fear conditioning, and of subjacent white matter in the pathology of PTSD...
  31. ncbi request reprint No effect of gender on tonal and phonetic mismatch negativity in normal adults assessed by a high-resolution EEG recording
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
    Brain Res Cogn Brain Res 13:305-12. 2002
    ....
  32. ncbi request reprint No association between the neuronal pentraxin II gene polymorphism and autism
    Tetsuya Marui
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:940-3. 2007
    ..Thus, the NPTX2 locus is not likely to play a major role in the development of autism. However, further studies with larger sample size and sequencing of NPTX2 gene are needed to exclude a role of NPTX2 gene in autism...
  33. ncbi request reprint Neuromagnetic correlates of impaired automatic categorical perception of speech sounds in schizophrenia
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 59:159-72. 2003
    ..The language-related dysfunction in schizophrenic patients may be present at the early stage of auditory processing of relatively simple stimuli such as phonemes, and not just at stages involving higher order semantic processes...
  34. ncbi request reprint Electrophysiological abnormalities of spatial attention in adults with autism during the gap overlap task
    Yuki Kawakubo
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo, Japan
    Clin Neurophysiol 118:1464-71. 2007
    ..We evaluated event-related potentials (ERPs) elicited by attentional disengagement in individuals with autism...
  35. doi request reprint Localized gray matter volume reductions in the pars triangularis of the inferior frontal gyrus in individuals at clinical high-risk for psychosis and first episode for schizophrenia
    Norichika Iwashiro
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 137:124-31. 2012
    ..The right PT might preferentially contribute to the pathogenesis of psychotic symptoms...
  36. doi request reprint Reduced gray matter volume of Brodmann's Area 45 is associated with severe psychotic symptoms in patients with schizophrenia
    Motomu Suga
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Eur Arch Psychiatry Clin Neurosci 260:465-73. 2010
    ..The present study further demonstrated that BA 45 might especially contribute to the production of psychotic symptoms in the patients with schizophrenia...
  37. ncbi request reprint The effect of perospirone on auditory P300 in schizophrenia: a preliminary study
    Tsuyoshi Araki
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1083-90. 2006
    ..These results suggest that clinical improvement in response to perospirone in some patients may, at least in part, be mediated through cognitive change indexed by P300 in chronic schizophrenia...
  38. ncbi request reprint Confirmation of a relationship between reduced auditory P300 amplitude and thought disorder in schizophrenia
    Kenji Kirihara
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyoku, Tokyo 113 8655, Japan
    Schizophr Res 80:197-201. 2005
    ..These results further suggest that electrophysiological abnormalities of information processing may underlie positive thought disorder in schizophrenia...
  39. ncbi request reprint Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia
    Yuki Kawakubo
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Neuroreport 17:1043-6. 2006
    ..These results suggest that electrophysiological auditory sensory memory dysfunction underlies the basis for neuropsychological auditory verbal memory deficits in schizophrenia...
  40. doi request reprint Association between severe dorsolateral prefrontal dysfunction during random number generation and earlier onset in schizophrenia
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Neurophysiol 122:1533-40. 2011
    ..Age at onset is a major factor for predicting social outcome in schizophrenia. In clinical settings, we need an objective assessment tool for evaluating prefrontal function and social outcome...
  41. ncbi request reprint No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo, 113 8655 Japan
    Schizophr Res 88:260-4. 2006
    ..Thus, the present study provides no positive evidence of an association between the GRM3 gene and schizophrenia in the Japanese population...
  42. pmc Association between catechol-O-methyltrasferase Val108/158Met genotype and prefrontal hemodynamic response in schizophrenia
    Ryu Takizawa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 4:e5495. 2009
    ..Here, we investigated spatiotemporal characteristics of the association between prefrontal hemodynamic activation and the COMT genotype using a noninvasive neuroimaging technique, near-infrared spectroscopy (NIRS)...
  43. doi request reprint Voxel-based analysis of the diffusion tensor
    Osamu Abe
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Neuroradiology 52:699-710. 2010
    ....
  44. ncbi request reprint Human brain structural change related to acute single exposure to sarin
    Hidenori Yamasue
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Ann Neurol 61:37-46. 2007
    ....
  45. doi request reprint Tract-specific analysis of the superior occipitofrontal fasciculus in schizophrenia
    Natsuko Kunimatsu
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
    Psychiatry Res 164:198-205. 2008
    ..726 (x10(-3) mm(2)/s) (S.D. 0.027)]. Our results suggest that the so-called SOFF may be a structural component connecting the prefrontal area to the thalamus and that it is deteriorated in schizophrenia...
  46. ncbi request reprint Do high or low doses of anxiolytics and hypnotics affect mismatch negativity in schizophrenic subjects? An EEG and MEG study
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Neurophysiol 113:141-50. 2002
    ....
  47. ncbi request reprint Auditory mismatch negativity and P3a in response to duration and frequency changes in the early stages of psychosis
    Tatsuya Nagai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Electronic address
    Schizophr Res 150:547-54. 2013
    ..To our knowledge, this is the first study that examined both MMN/P3a to duration deviant (dMMN/dP3a) and frequency deviant (fMMN/fP3a) in the early stages of psychosis...
  48. doi request reprint Mitigation of sociocommunicational deficits of autism through oxytocin-induced recovery of medial prefrontal activity: a randomized trial
    Takamitsu Watanabe
    Department of Neuropsychiatry, School of Medicine, University of Tokyo, Tokyo, Japan2Department of Physiology, School of Medicine, University of Tokyo, Tokyo, Japan
    JAMA Psychiatry 71:166-75. 2014
    ..Despite growing prospects for oxytocin as a therapeutic agent for ASD, no direct neurobiological evidence exists for oxytocin's beneficial effects on this core symptom of ASD. This is slowing clinical application of the neuropeptide...
  49. doi request reprint A multimodal approach to investigate biomarkers for psychosis in a clinical setting: the integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project
    Shinsuke Koike
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 143:116-24. 2013
    ..0%, and 35.3% (at 6, 12, and 24months, respectively). Through this research project, we expect to clarify the pathophysiological features around the onset of psychosis and improve the prognosis of psychosis through clinical application...
  50. doi request reprint Association and interaction analyses of NRG1 and ERBB4 genes with schizophrenia in a Japanese population
    Sae Shiota
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, 113 8655, Japan
    J Hum Genet 53:929-35. 2008
    ..Thus, our results suggest the possibility that interaction between variants in NRG1 and ERBB4 might contribute to susceptibility for schizophrenia in a Japanese population. Further investigation may be necessary to confirm our results...
  51. doi request reprint Differentiation between bipolar disorder and schizophrenia revealed by neural oscillation to speech sounds: an MEG study
    Naoya Oribe
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    Bipolar Disord 12:804-12. 2010
    ..The current study tested the hypothesis that the eNO to speech sounds could be differentiated between BP and SZ patients...
  52. doi request reprint Gender difference in right lateral prefrontal hemodynamic response while viewing fearful faces: a multi-channel near-infrared spectroscopy study
    Kohei Marumo
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Neurosci Res 63:89-94. 2009
    ..This observation may help to establish NIRS as a clinical tool for monitoring prefrontal function on an individual basis...
  53. ncbi request reprint Brain electric activity for active inhibition of auditory irrelevant information
    Tsuyoshi Araki
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Lett 374:11-6. 2005
    ..These results suggest that auditory selective attention process involves not only focusing attention on relevant information, but also inhibitory processing of irrelevant information mediated by the frontal cortex...
  54. ncbi request reprint Aging in the CNS: comparison of gray/white matter volume and diffusion tensor data
    Osamu Abe
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurobiol Aging 29:102-16. 2008
    ..These results indicate that diffusion properties and brain volume are complementary markers to the effects of aging...
  55. ncbi request reprint Tachykinin 1 (TAC1) gene SNPs and haplotypes with autism: a case-control study
    Tetsuya Marui
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Brain Dev 29:510-3. 2007
    ..Thus, the TAC1 locus is not likely to play a major role in the development of autism...
  56. ncbi request reprint Gender-common and -specific neuroanatomical basis of human anxiety-related personality traits
    Hidenori Yamasue
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cereb Cortex 18:46-52. 2008
    ..The results may have implications for why susceptibility to stress-related disorders such as anxiety disorders and depression shows gender and/or individual differences...
  57. ncbi request reprint Electrophysiological indices associated with social functioning outcome in schizophrenia: a 5-year follow-up study
    Keiko Maeda
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Res 51:215-8. 2005
    ..N2b amplitude, an electrophysiological index of orienting response, may be associated with longitudinal social functioning outcome in schizophrenia...
  58. ncbi request reprint Reduced planum temporale volume and delusional behaviour in patients with schizophrenia
    Syudo Yamasaki
    Department of Rehabilitation, Graduate School of Medicine, The University of Tokyo, Tokyo, 113 8655, Japan
    Eur Arch Psychiatry Clin Neurosci 257:318-24. 2007
    ....
  59. pmc Diminished medial prefrontal activity behind autistic social judgments of incongruent information
    Takamitsu Watanabe
    Department of Physiology, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 7:e39561. 2012
    ....
  60. ncbi request reprint P300 amplitude over temporal regions in schizophrenia
    Akira Iwanami
    Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Japan
    Eur Arch Psychiatry Clin Neurosci 252:1-7. 2002
    ....
  61. doi request reprint Sex-linked neuroanatomical basis of human altruistic cooperativeness
    Hidenori Yamasue
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cereb Cortex 18:2331-40. 2008
    ..The present findings may also have an implication for the pathophysiology of autism; characterized by severe dysfunction in social reciprocity, abnormalities in social-brain, and disproportionately low probability in females...
  62. ncbi request reprint Perospirone in the treatment of schizophrenia: effect on verbal memory organization
    Tsuyoshi Araki
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:204-8. 2006
    ..Negative symptoms and extrapyramidal side effects were also ameliorated after switching to perospirone. The distinct cognitive enhancement profile of perospirone may be attributable to its partial 5-HT1A agonist action...
  63. pmc Classification of first-episode schizophrenia patients and healthy subjects by automated MRI measures of regional brain volume and cortical thickness
    Yoichiro Takayanagi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan
    PLoS ONE 6:e21047. 2011
    ....
  64. doi request reprint Age-related changes in regional brain volume evaluated by atlas-based method
    Wataru Gonoi
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Neuroradiology 52:865-73. 2010
    ..We introduce an atlas-based method as a methodological alternative that calculates absolute volume as a non-biased and semi-automatic whole-brain technique...
  65. pmc Effects of metabotropic glutamate receptor 3 genotype on phonetic mismatch negativity
    Yuki Kawakubo
    Department of Child Neuropsychiatry, University of Tokyo, Tokyo, Japan
    PLoS ONE 6:e24929. 2011
    ..Variations in metabotropic glutamate receptor (GRM3) may be associated with schizophrenia, and has been shown to affect cortical function. Here we investigated the effect of GRM3 genotypes on phonetic MMF in healthy men...
  66. pmc Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study of combat-related posttraumatic stress disorder
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Biol Psychiatry 63:550-6. 2008
    ..We employed a case-control design in monozygotic twin pairs discordant for combat exposure to address the preexisting versus acquired origin of brain morphometric abnormalities in PTSD...
  67. doi request reprint Reduced gray matter volume of pars opercularis is associated with impaired social communication in high-functioning autism spectrum disorders
    Syudo Yamasaki
    Department of Neuropsychiatry, University of Tokyo, Japan
    Biol Psychiatry 68:1141-7. 2010
    ..However, the structural abnormality of this region has not fully been clarified in subjects with ASD...
  68. doi request reprint Aging effects on cerebral asymmetry: a voxel-based morphometry and diffusion tensor imaging study
    Hidemasa Takao
    Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Magn Reson Imaging 28:65-9. 2010
    ..Our results showed no significant effects of aging on either gray matter volume asymmetry or white matter fractional anisotropy asymmetry...
  69. ncbi request reprint Abnormal association between reduced magnetic mismatch field to speech sounds and smaller left planum temporale volume in schizophrenia
    Hidenori Yamasue
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo 113 8655, Japan
    Neuroimage 22:720-7. 2004
    ..These results suggest that structural abnormalities of the planum temporale may underlie the functional abnormalities of fundamental language-related processing in schizophrenia...
  70. ncbi request reprint Procedural memory predicts social skills in persons with schizophrenia
    Yuki Kawakubo
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Nerv Ment Dis 194:625-7. 2006
    ..038), but not for verbal communication skills or processing skills. Although preliminary, these results provide the first evidence of an association between procedural memory and nonverbal social skills in patients with schizophrenia...
  71. doi request reprint Structural and diffusional brain abnormality related to relatively low level alcohol consumption
    Hiroki Sasaki
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neuroimage 46:505-10. 2009
    ..The current results suggest female brain vulnerability to alcohol, and a relation between subtle abnormality in the right amygdala and alcohol misuse...
  72. doi request reprint Reduced amygdala and hippocampal volumes in patients with methamphetamine psychosis
    Lina Orikabe
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 132:183-9. 2011
    ....