Research Topics
| Hiroshi KasaiSummaryAffiliation: University of Occupational and Environmental Health Country: Japan Publications
| Collaborators
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Detail Information
Publications
Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesisH Kasai
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan
Mutat Res 387:147-63. 1997..The validity of the general use of 8-OH-dG as a marker of cellular oxidative stress is discussed...- A new automated method to analyze urinary 8-hydroxydeoxyguanosine by a high-performance liquid chromatography-electrochemical detector systemHiroshi Kasai
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University, of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
J Radiat Res 44:185-9. 2003..Up to 1,000 human urine samples can be continuously analyzed with high accuracy within a few months. This method will be useful for studies in radiotherapy, molecular epidemiology, risk assessment, and health promotion... - Detection of a smaller, 32-kDa 8-oxoguanine DNA glycosylase 1 in 3'-methyl-4-dimethylamino-azobenzene-treated mouse liverTakeshi Hirano
Department of Environmental Oncology, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Fukuoka 807 8555, Japan
Cancer Sci 95:118-22. 2004..Although the function of mOGG1-32 remains unclear, these findings suggest that 3'-MeDAB may alter the function of the DNA repair protein, and this action may be related to 3'-MeDAB carcinogenesis... 
DNA methylation at the C-5 position of cytosine by methyl radicals: a possible role for epigenetic change during carcinogenesis by environmental agentsHiroshi Kasai
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1 1, Iseigaoka, Yahatanishi ku, Kitakyushu, 807 8555, Japan
Chem Res Toxicol 22:984-9. 2009..We propose here that this reaction is one of the important mechanisms of de novo DNA methylation during carcinogenesis, because methyl radicals are produced by the biotransformation of various endogenous and exogenous compounds...- 4-oxo-2-hexenal, a mutagen formed by omega-3 fat peroxidation: occurrence, detection and adduct formationHiroshi Kasai
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
Mutat Res 659:56-9. 2008..Since 4-OHE induces DNA adduct formation in experimental animal organs, further studies on the carcinogenicity of 4-OHE and the detection of 4-OHE-DNA adducts in human tissue will be required... - Chemistry-based studies on oxidative DNA damage: formation, repair, and mutagenesisHiroshi Kasai
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan
Free Radic Biol Med 33:450-6. 2002..By these studies, we found solid chemistry-based approaches were often useful to clarify the biological phenomena... - Analyses of oxidative DNA damage and its repair activity in the livers of 3'-methyl-4-dimethylaminoazobenzene-treated rodentsT Hirano
Department of 1 Environmental Oncology, University of Occupational and Environmental Health, Japan
Jpn J Cancer Res 91:681-5. 2000..6-fold and 1.6-fold, respectively. These experiments suggest that 3'-MeDAB increases 8-OH-Gua generation in rodent liver DNA and the 8-OH-Gua repair assay is a reliable marker of cellular oxidative stress induced by carcinogens... - Life style and urinary 8-hydroxydeoxyguanosine, a marker of oxidative dna damage: effects of exercise, working conditions, meat intake, body mass index, and smokingH Kasai
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu 807 8555, Japan
Jpn J Cancer Res 92:9-15. 2001..013), and day-night shift work (P = 0.044) increased its level. These results suggest that many types of life-style factors that either generate or scavenge oxygen radicals may affect the level of oxidative DNA damage of each individual... - 8-Hydroxyguanine levels and repair capacity during mouse embryonic stem cell differentiationAyumi Kuboyama
Department of Chemical Processes and Environments, Faculty of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka, 808 0135, Japan
Free Radic Res 45:527-33. 2011..Taken together, ES cells are more resistant to DNA oxidative stresses than differentiated cells... - Effect of age, smoking and other lifestyle factors on urinary 7-methylguanine and 8-hydroxydeoxyguanosineKazuyoshi Tamae
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
Cancer Sci 100:715-21. 2009..Therefore, the urinary m7Gua level is considered to be a useful marker of DNA methylation, not only from smoking, but also from aging and unhealthy dietary habits... - Identification of 4-oxo-2-hexenal and other direct mutagens formed in model lipid peroxidation reactions as dGuo adductsMuneyuki Maekawa
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health (UOEH, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
Chem Res Toxicol 19:130-8. 2006..We confirmed the mutagenic activity of 4-OHE with Salmonella strains, TA100 and TA104, without S9 mix. These compounds may be involved in lipid peroxide-related cancers... - DNA modifications by the omega-3 lipid peroxidation-derived mutagen 4-oxo-2-hexenal in vitro and their analysis in mouse and human DNAKazuaki Kawai
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1 1, Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
Chem Res Toxicol 23:630-6. 2010..6-5.9/10(9) bases. No difference in the 4-OHE adduct levels was detected between smokers and nonsmokers. Our results suggest that 4-OHE-DNA adducts are formed by endogenous as well as environmental lipid peroxides... - Analysis of 8-hydroxyguanine (8-OH-Gua) released from DNA by the formamidopyrimidine DNA glycosylase (Fpg) protein: a reliable method to estimate cellular oxidative stressHiroshi Orimo
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan
J Radiat Res (Tokyo) 45:455-60. 2004..With our new analysis method, it is possible to detect the small changes in the 8-OH-Gua levels in cellular DNA induced by various environmental factors... - Formation of 8-hydroxy-2'-deoxyguanosine in the DNA of cultured human keratinocytes by clinically used doses of narrowband and broadband ultraviolet B and psoralen plus ultraviolet AHiroshi Orimo
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
Cancer Sci 97:99-105. 2006..Our study provides a warning that widely used narrowband UVB and PUVA induce cellular oxidative DNA damage at the therapeutically used doses, although to a lesser degree than broadband UVB with the same clinically effective dose... - Urea, the most abundant component in urine, cross-reacts with a commercial 8-OH-dG ELISA kit and contributes to overestimation of urinary 8-OH-dGMing Fen Song
Department of Environmental Oncology, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
Free Radic Biol Med 47:41-6. 2009..In addition, performance of the ELISA at 4 degrees C reduced the recognition of urea considerably and improved the 8-OH-dG analysis... - Increase of human MTH1 and decrease of 8-hydroxydeoxyguanosine in leukocyte DNA by acute and chronic exercise in healthy male subjectsYuji Sato
Department of Health Development, University of Occupational and Environmental Health, Iseigaoka, Yahata-Nishiku, Kitakyushu 807-8555, Japan
Biochem Biophys Res Commun 305:333-8. 2003..These results suggest that a mild exercise has a beneficial effect on the maintenance of low levels of 8-OH-dG probably by keeping the sanitization system at higher levels... - 4-oxo-2-hexenal, a mutagen formed by omega-3 fat peroxidation, causes DNA adduct formation in mouse organsHiroshi Kasai
Department of Environmental Oncology, Institute of Industrial Ecological Sciences University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
Ind Health 43:699-701. 2005..The 4-OHE seems to be produced by the auto-oxidation of omega-3 polyunsaturated fatty acids. These results provide a warning to workers dealing with omega-3 fats, who may be exposed to this volatile mutagen... - Chronic alcohol consumption prevents 8-hydroxyguanine accumulation in 3'-methyl-4-dimethylaminoazobenzene-treated mouse liverTakeshi Hirano
Department of Life and Environment Engineering, Faculty of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka 808 0135, Japan
Biochem Biophys Res Commun 387:316-20. 2009..These findings suggested that 12% ethanol consumption may reduce the risk of 3'-MeDAB-induced carcinogenesis by decreasing 8-OH-Gua accumulation... - Urinary 8-hydroxyguanine may be a better marker of oxidative stress than 8-hydroxydeoxyguanosine in relation to the life spans of various speciesPeter Svoboda
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan
Antioxid Redox Signal 8:985-92. 2006..91, p = 0.01) or 8- OH-Gua/creatinine (r = 0.90, p = 0.01). These results suggest that 8-OH-Gua, rather than 8-OH-dG, may be a more general marker for oxidative damage... - Detection of a mouse OGG1 fragment during caspase-dependent apoptosis: oxidative DNA damage and apoptosisTakeshi Hirano
Department of Environmental Oncology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, Japan
Cancer Sci 95:634-8. 2004.... - Analysis of 8-hydroxydeoxyguanosine 5'-monophosphate (8-OH-dGMP) as a reliable marker of cellular oxidative DNA damage after gamma-irradiationNan Mei
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan
Environ Mol Mutagen 41:332-8. 2003..Using an endonuclease nicking assay, we also found that gamma-rays decreased 8-OH-Gua repair activity. The results indicate that 8-OH-dGMP is a useful and sensitive marker for estimating oxidative damage in DNA... - Effect of polymerized toner on rat lung in chronic inhalation studyYasuo Morimoto
Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan
Inhal Toxicol 21:898-905. 2009..A significant production of 8-OHdG was not observed in the toner exposed groups. In conclusion, toner produced by polymerization was not associated with evidence of carcinogenesis in this experiment... - 8-hydroxydeoxyguanosine generated in the earthworm Eisenia fetida grown in metal-containing soilTamiji Nakashima
Department of Anatomy, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, Fukuoka 807 8555, Japan
Mutat Res 654:138-44. 2008..Although some points remain unresolved, a bio-monitoring system analyzing the DNA damage generated in the earthworm might be useful for the assessment of the mutagenicity of soil contaminated with various heavy metals, such as Cd... - DNA methylation by dimethyl sulfoxide and methionine sulfoxide triggered by hydroxyl radical and implications for epigenetic modificationsKazuaki Kawai
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1 1, Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
Bioorg Med Chem Lett 20:260-5. 2010..In addition to m(5)dC, the formation of 8-methyldeoxyguanosine (m(8)dG) was also detected in DNA under the same reaction conditions. The m(8)dG level in human DNA may be a useful indicator of DNA methylation by radical mechanisms... - Simultaneous determination of 8-hydroxydeoyguanosine, a marker of oxidative stress, and creatinine, a standardization compound, in urineHiroshi Kasai
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
Ind Health 43:333-6. 2005..In this communication, we report a method for the simultaneous determination of 8-OH-dG and creatinine, an internal standard for normalizing the excretion of 8-OH-dG in urine... - Relations between clusters of oxidatively damaged nucleotides and active or open nucleosomes in the rat Nth 1 geneMinoru Nomoto
Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Japan, Yahata nishi ku, Kitakyushu 807 8555, Japan
Oncogene 21:1649-57. 2002..Taking into account the function of the protein segment encoded by these regions, we discussed the molecular mechanism of the restricted formation of the damaged nucleotides... - Effect of work conditions and work environments on the formation of 8-OH-dG in nurses and non-nurse female workersItsuko Ishihara
Department of Public Health and Occupational Health Nursing, School of Health Sciences, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu 807 8555, Japan
J UOEH 30:293-308. 2008..32, P < 0.05). Together, it was suggested that a heavy burden of work in addition to daily domestic roles increases urinary excretion levels of 8-OH-dG... - Detection of 4-oxo-2-hexenal, a novel mutagenic product of lipid peroxidation, in human diet and cooking vaporKazuaki Kawai
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
Mutat Res 603:186-92. 2006..The 4-OHE may be produced from omega-3 polyunsaturated fats, such as alpha-linolenic acid-, docosahexaenoic acid (DHA)- and eicosapentaenoic acid (EPA)-TG, which are more easily oxidized than omega-6 fats, such as linoleic acid-TG... - The oxidized pyrimidine ribonucleotide, 5-hydroxy-CTP, is hydrolyzed efficiently by the Escherichia coli recombinant Orf135 proteinKatsuyoshi Fujikawa
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
DNA Repair (Amst) 1:571-6. 2002..This result indicates that 5-hydroxy-CTP is the best substrate of Orf135 among the nucleotides tested... - Acute arsenite-induced 8-hydroxyguanine is associated with inhibition of repair activity in cultured human cellsNan Mei
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807-8555, Japan
Biochem Biophys Res Commun 297:924-30. 2002.... - Negative effect of long-term inhalation of toner on formation of 8-hydroxydeoxyguanosine in DNA in the lungs of rats in vivoYasuo Morimoto
Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Inhal Toxicol 17:749-53. 2005..Inhalation of the toner for 1 and even 2 yr did not induce the formation of 8-OH-Gua in DNA in rat lungs. These data suggest that long-term inhalation of toner may not induce lung tumors... 
Metal nanoparticle-induced micronuclei and oxidative DNA damage in miceMing Fen Song
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1 1, Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
J Clin Biochem Nutr 50:211-6. 2012..In conclusion, the metal nanoparticles caused genotoxicity, and oxidative stress may be responsible for the toxicity of these metal nanoparticles...- Simultaneous HPLC analysis of 8-hydroxydeoxyguanosine and 7-methylguanine in urine from humans and rodentsPeter Svoboda
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
Anal Biochem 334:239-50. 2004.... - Psychological mediation of a type of oxidative DNA damage, 8-hydroxydeoxyguanosine, in peripheral blood leukocytes of non-smoking and non-drinking workersMasahiro Irie
Department of Mental Health, Institute of Industrial Ecological Sciences, Kitakyushu, Japan
Psychother Psychosom 71:90-6. 2002.... - Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathwayYoshihiro Yasuniwa
Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
PLoS ONE 5:e15330. 2010..These findings suggest that circadian disruption induces the progression of malignant tumors via a Wnt signaling pathway... - Human mitochondrial transcription factor A binds preferentially to oxidatively damaged DNAYoichiro Yoshida
Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Fukuoka, Japan
Biochem Biophys Res Commun 295:945-51. 2002..The affinity for oxidatively damaged DNA of mtTFA is higher for A/8-oxo-dG and C/8-oxo-dG than for G/8-oxo-dG and T/8-oxo-dG. Our findings suggest that mtTFA plays an important role in the recognition of oxidative DNA damage... - Urinary 8-hydroxydeoxyguanosine levels and psychological reactions after sleep deprivationKazunori Ikegami
Department of Mental Health, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan Yahatanishi ku, Kitakyushu 807 8555, Japan
J UOEH 32:1-10. 2010..These results suggest that the effect of one night of SD on psychological reactions continued for 2 or 3 days, and SD might not influence urinary 8-OH-dG levels despite marked changes in psychological reactions... - Cross-sectional study on respiratory effect of toner exposureNiina Terunuma
Institute of Industrial and Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyusyu, Japan
Hum Exp Toxicol 28:325-30. 2009..It should also be noted that this tendency did not exceed that of the general public. Further analysis is required in this ongoing 10-year cohort study to clarify the effect of toner exposure on the respiratory system... - A very low level of magnetic field exposure does not affect a participant's mental fatigue and stress as much as VDT workItsuko Ishihara
Department of Public Health and Occupational Health Nursing, School of Health Sciences, University of Occupational and Environmental Health, Japan, Yahatanishi-ku, Kitakyushu 807-8555, Japan
J UOEH 27:25-40. 2005..Taken together, the results of this study did not detect any bad health effects of MF exposure on the VDT participants but suggested that VDT work itself affects their mental fatigue and psycho-physiological status... - Chronic arsenic exposure and urinary 8-hydroxy-2'-deoxyguanosine in an arsenic-affected area in Inner Mongolia, ChinaYoshihisa Fujino
Department of Clinical Epidemiology, Institute of Industrial Ecological Science, University of Occupational and Environmental Health, Japan
J Expo Anal Environ Epidemiol 15:147-52. 2005..CONCLUSIONS: These results provide evidence of a link between exposure to arsenic from drinking water and oxidative stress, which may play an important role in arsenic-involved injuries... - 8-Chloro-dGTP, a hypochlorous acid-modified nucleotide, is hydrolyzed by hMTH1, the human MutT homologKatsuyoshi Fujikawa
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, 807 8555, Kitakyushu, Japan
FEBS Lett 512:149-51. 2002..The kinetic parameters revealed that 8-chloro-dGTP was degraded by hMTH1 with 50% efficiency as compared with that of 8-hydroxy-dGTP. This result suggests that 8-chloro-dGTP is an intrinsic substrate for hMTH1... - Induction of T --> G and T --> A transversions by 5-formyluracil in mammalian cellsHiroyuki Kamiya
Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
Mutat Res 513:213-22. 2002..C and 5-fU.T base pairs, respectively. This is the first report that clearly shows the induction of transversion mutations by an oxidized pyrimidine base in DNA in mammalian cells... - UvrA and UvrB enhance mutations induced by oxidized deoxyribonucleotidesMika Hori
Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
DNA Repair (Amst) 6:1786-93. 2007..Thus, UvrA and UvrB are involved in the enhancement, but not in the suppression, of the mutations induced by these oxidized deoxyribonucleotides. These results suggest a novel role for UvrA and UvrB in the processing of oxidative damage... - Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine values measured by an ELISA correlated well with measurements by high-performance liquid chromatography with electrochemical detectionRie Yoshida
National Institute of Industrial Health, Kawasaki 214-8585, Japan
Cancer Epidemiol Biomarkers Prev 11:1076-81. 2002..These results show that the ELISA can be applied to studies comparing relative urinary 8-oxo-dG values among several groups, if the studies do not require determination of the exact concentration of 8-oxo-dG in urine... - Lack of initiation activity of 4-oxo-2-hexenal, a peroxidation product generated from omega-3 polyunsaturated fatty acids, in an in vivo five-week liver assayShinji Takasu
Division of Oncological Pathology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
Asian Pac J Cancer Prev 8:372-4. 2007..78?1.33). Areas of GST-P positive foci were also similar (1.11-/+0.5 and 1.53-/+1.33 mm2/cm2 in "128" and the control groups, respectively). These results showed 4-OHE to have no significant initiation activity in... - Prospective study of 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion and the risk of lung cancerSteffen Loft
Department of Environmental and Occupational Health, University of Copenhagen, Denmark
Carcinogenesis 27:1245-50. 2006..8 (1.21-115) per doubling of 8-oxodG excretion. The association between 8-oxodG excretion and lung cancer risk among never-smokers suggests that oxidative damage to DNA nucleotides is important in this group... - Changes of 8-OH-dG levels in DNA and its base excision repair activity in rat lungs after inhalation exposure to hexavalent chromiumSeung-Hee Maeng
Center for Occupational Toxicology, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Daejeon 305-380, South Korea
Mutat Res 539:109-16. 2003..However, the 8-OH-dG levels and its repair activities recovered to the level of the controls in the latter inhalation exposure period... - Mutagenic effects of 8-hydroxy-dGTP in live mammalian cellsKazuya Satou
Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Sapporo 060 0812, Japan
Free Radic Biol Med 42:1552-60. 2007..coli. These results constitute the first direct evidence to show that 8-OH-dGTP actually induces mutations in living mammalian cells... - Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesisShinya Akatsuka
Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
Am J Pathol 169:1328-42. 2006..This versatile technique would introduce a novel research area as a high-throughput screening method for critical genomic loci under oxidative stress... - Analysis of 8-hydroxydeoxyguanosine among workers exposed to diesel particulate exhaust: comparison with urinary metabolites and PAH air monitoringMinna Harri
Finnish Institute of Occupational Health, Helsinki, Finland
Free Radic Res 39:963-72. 2005..01, n=28, P=0.96). The PAH exposure at workplaces was mainly composed of volatile compounds, particularly naphthalene, suggesting low exposure through the respiratory tract and a low effect of PAH in ROS induction... - Oxidative DNA damage: mechanisms and significance in health and diseaseHiroshi Kasai
Antioxid Redox Signal 8:981-3. 2006 - Occupational and lifestyle factors and urinary 8-hydroxydeoxyguanosineMasahiro Irie
Institute of Health Science, Kyushu University, 6 1 Kasuga Park, Kasuga, Fukuoka 816 8580, Japan
Cancer Sci 96:600-6. 2005..We suggest that several occupational and lifestyle factors, particularly long working hours and cigarette smoking, are linked to the formation of 8-OH-dG in workers... - Habitual exercise induced resistance to oxidative stressKoji Nakatani
Department of Environmental Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, 890-8544, Japan
Free Radic Res 39:905-11. 2005..These results suggest that HE induces resistance to oxidative stress and, at least at the initiation stage, inhibits carcinogenesis... - Comparison between high-performance liquid chromatography and enzyme-linked immunosorbent assay for the determination of 8-hydroxy-2'-deoxyguanosine in human urineKayoko Shimoi
Institute for Environmental Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422 8526
Cancer Epidemiol Biomarkers Prev 11:767-70. 2002..It is suggested that the ELISA system is applicable for comparative human monitoring studies. Prepurification of 'samples is required to determine the absolute value of 8-OH-dG in individual urine samples by ELISA... - Evaluation of oxidative stress in a group of adolescents exposed to a high level of aflatoxin B1--a multi-center and multi-biomarker studyTao Peng
Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Province, China
Carcinogenesis 28:2347-54. 2007..These findings suggest significant contribution from AFB1 exposure to oxidative stress and subsequent repair among adolescents that may impose substantial risk for hepatocarcinogenesis in adulthood in this region... - Suppression of hyperemia and DNA oxidation by indomethacin in cerebral ischemiaOsamu Miyamoto
Department of Neurobiology, Kagawa Medical University, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan
Eur J Pharmacol 459:179-86. 2003..05). These results suggest that indomethacin may protect neurons by attenuating oxidative stress and reperfusion injury in ischemic insult... - An oxidized nucleotide affects DNA replication through activation of protein kinases in Xenopus egg lysatesToshinori Kai
Graduate School of Science and Technology, Faculty of Science, Kumamoto University, 2-39-1 Kurokami, Kumamoto 860-8555, Japan
Nucleic Acids Res 30:569-73. 2002..Therefore, the mechanism of delay of DNA synthesis by 8-oxo-dGTP may be different from that by UV lesions. This is the first report that demonstrates an effect of an oxidized nucleotide on DNA replication in eukaryotes... - Induction of OGG1 gene expression by HIV-1 TatKenichi Imai
Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601
J Biol Chem 280:26701-13. 2005..These findings collectively indicate the possibility that Tat may play a role in maintenance of the genetic integrity of the proviral and host cellular genomes by up-regulating OGG1 as a feed-forward mechanism... - The stability of the oxidative stress marker, urinary 8-hydroxy-2'- deoxyguanosine (8-OHdG), when stored at room temperatureYuki Matsumoto
National Institute of Occupational Safety and Health, Kawasaki, Japan
J Occup Health 50:366-72. 2008..We conclude that urine samples can be stored at 25 degrees C and below for 24 h, when the research purpose includes the determination of urinary 8-OHdG. Urinary 8-OHdG was also stable for over two years when stored at -80 degrees C... - Depressive state relates to female oxidative DNA damage via neutrophil activationMasahiro Irie
Institute of Health Science, Kyushu University, 6 1 Kasuga Park, Kasuga, 816 8580, Fukuoka, Japan
Biochem Biophys Res Commun 311:1014-8. 2003..There was a positive correlation between the percentage of neutrophils and the 8-OH-dG levels in females. Psychological depression was related to cancer risk due to oxidative DNA damage in females, possibly via neutrophil activation... - Depression and possible cancer risk due to oxidative DNA damageMasahiro Irie
Second Department of Health Sciences Clinical Science and Psychology, Institute of Health Science, Kyushu University, Kasuga, Fukuoka 816 8580, Japan
J Psychiatr Res 39:553-60. 2005..This study suggests that clinical depression is a risk factor for cancer initiation in view of oxidative DNA damage... - Dual hydrolysis of diphosphate and triphosphate derivatives of oxidized deoxyadenosine by Orf17 (NtpA), a MutT-type enzymeMika Hori
Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
DNA Repair (Amst) 4:33-9. 2005..These results suggest that the Orf17 protein may be involved in the hydrolysis of oxidized dATP and dADP... - Leanness, smoking, and enhanced oxidative DNA damageTetsuya Mizoue
Department of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashiku, 812 8582 Fukuoka, Japan
Cancer Epidemiol Biomarkers Prev 15:582-5. 2006..The interaction of smoking and BMI reached statistical significance (P = 0.04). Leanness may enhance oxidative DNA damage induced by smoking and thus serve as a marker of host susceptibility to smoking-related cancers... - Absence of in vivo genotoxic potential and tumor initiation activity of kojic acid in the rat thyroidToru Tamura
Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
Toxicology 222:213-24. 2006.... - [Relationship between length of sleep and oxidative stress marker, urinary 8-hydroxy-2'-deoxyguanosine]Yuki Matsumoto
National Institute of Industrial Health, Kawasaki
Nippon Eiseigaku Zasshi 61:357-65. 2006..3) The length of habitual sleep had no effect on SU8-OH-dG level... - Suppression of chemically induced and spontaneously occurring oxidative mutagenesis by three alleles of human OGG1 gene encoding 8-hydroxyguanine DNA glycosylaseSu-Ryang Kim
Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
Mutat Res 554:365-74. 2004..These results suggest that three alleles of the hOGG1 gene efficiently suppress chemically induced and spontaneously occurring oxidative mutagenesis, and that hOGG1-Gln46 may have a weaker ability to suppress the mutations... - Analysis of 8-hydroxy-2'-deoxyguanosine in urine using high-performance liquid chromatography-electrospray tandem mass spectrometryMinna Harri
Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, 00250 Helsinki, Finland
J Chromatogr B Analyt Technol Biomed Life Sci 853:242-6. 2007..49 to 14.27 microg of 8-OHdG/g creatinine. The correlation between the developed HPLC-MS/MS method and the existing HPLC-EC method was good with an R2 value of 0.8707... - 2-Hydroxy-2'-deoxyadenosine 5'-triphosphate enhances A.T --> C.G mutations caused by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate by suppressing its degradation upon replication in a HeLa extractKazuya Satou
Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
Biochemistry 46:6639-46. 2007..These results highlight the importance of specific hydrolysis of 8-OH-dGTP for the suppression of its induced mutation... - Body mass index and oxidative DNA damage: a longitudinal studyTetsuya Mizoue
Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Tokyo 162 8655, Japan
Cancer Sci 98:1254-8. 2007..7% increase). The results based on a longitudinal observation suggest that weight loss is associated with increased oxidative DNA damage, a state presumably related to an increased risk of cancer... - Prospective study of urinary excretion of 7-methylguanine and the risk of lung cancer: Effect modification by mu class glutathione-S-transferasesSteffen Loft
Department of Environmental and Occupational Health, University of Copenhagen, Denmark
Int J Cancer 121:1579-84. 2007..The finding of an association between m(7)Gua excretion and lung cancer risk mainly among current smokers and subjects with GSTM1 null genotype supports causality in this respect... - Increased levels of 8-hydroxy-2'-deoxyguanosine in Drosophila larval DNA after irradiation with 364-nm laser light but not with X-raysTomoe Negishi
Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima, Okayama, Japan
Photochem Photobiol 83:658-63. 2007..The overall results suggest significant differences in the major in vivo oxidative damage caused by 364-nm light and X-rays... - Effects of 8-hydroxy-GTP and 2-hydroxy-ATP on in vitro transcriptionHiroyuki Kamiya
Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
Free Radic Biol Med 43:837-43. 2007..8-OH-GTP induced T-->G plus T-->C mutations, and 2-OH-ATP caused T-->C mutations. These results indicate that the formation of these oxidized RNA precursors in cells affects transcription quantitatively and qualitatively... - UVA1 genotoxicity is mediated not by oxidative damage but by cyclobutane pyrimidine dimers in normal mouse skinHironobu Ikehata
Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai, Japan
J Invest Dermatol 128:2289-96. 2008.... - Negative association between serum dioxin level and oxidative DNA damage markers in municipal waste incinerator workersJin Yoshida
Department of Environmental Health, Osaka Prefectural Institute of Public Health, Osaka, 1 3 69, Nakamichi, Higashinari ku, 537 0025, Japan
Int Arch Occup Environ Health 79:115-22. 2006....