Kiyoshi Kano

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi Discoidin domain receptor 2 (DDR2) is required for maintenance of spermatogenesis in male mice
    Kiyoshi Kano
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Mol Reprod Dev 77:29-37. 2010
  2. pmc A novel dwarfism with gonadal dysfunction due to loss-of-function allele of the collagen receptor gene, Ddr2, in the mouse
    Kiyoshi Kano
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo 113 8657, Japan
    Mol Endocrinol 22:1866-80. 2008
  3. ncbi Insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure in porcine growing oocytes
    Takanori Nishimura
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Reprod Dev 55:553-7. 2009
  4. pmc Transcriptome analysis reveals an unexpected role of a collagen tyrosine kinase receptor gene, Ddr2, as a regulator of ovarian function
    Hirokazu Matsumura
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo, Japan
    Physiol Genomics 39:120-9. 2009
  5. ncbi Analyses of the involvement of PKA regulation mechanism in meiotic incompetence of porcine growing oocytes
    Takanori Nishimura
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Science, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Biol Reprod 87:53. 2012
  6. doi CDK7 and CCNH are components of CDK-activating kinase and are required for meiotic progression of pig oocytes
    Wataru Fujii
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Science, University of Tokyo, Tokyo, Japan
    Biol Reprod 85:1124-32. 2011
  7. ncbi Identification of whey acidic protein (WAP) in dog milk
    Mami Seki
    Laboratory of Applied Genetics, The University of Tokyo, Japan
    Exp Anim 61:67-70. 2012
  8. doi Functions of FZR1 and CDC20, activators of the anaphase-promoting complex, during meiotic maturation of swine oocytes
    Tadashi Yamamuro
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Biol Reprod 79:1202-9. 2008
  9. doi Porcine Aurora A accelerates Cyclin B and Mos synthesis and promotes meiotic resumption of porcine oocytes
    Yukio Nishimura
    Department of Animal Resource Sciences, Graduate School of Agricultural Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Anim Reprod Sci 113:114-24. 2009
  10. ncbi Whey acidic protein (WAP) regulates the proliferation of mammary epithelial cells by preventing serine protease from degrading laminin
    Naoko Nukumi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Cell Physiol 213:793-800. 2007

Collaborators

Detail Information

Publications29

  1. doi Discoidin domain receptor 2 (DDR2) is required for maintenance of spermatogenesis in male mice
    Kiyoshi Kano
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Mol Reprod Dev 77:29-37. 2010
    ..DDR2 was expressed in the Leydig cells of adult wild-type male mice. In conclusion, our results indicated that DDR2 signaling plays a critical role in the maintenance of male spermatogenesis...
  2. pmc A novel dwarfism with gonadal dysfunction due to loss-of-function allele of the collagen receptor gene, Ddr2, in the mouse
    Kiyoshi Kano
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo 113 8657, Japan
    Mol Endocrinol 22:1866-80. 2008
    ..Taken together, our results indicate that the absence of DDR2 leads to growth retardation and gonadal dysfunction due to peripheral defects in hormonal-responsive pathways in slie mice...
  3. ncbi Insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure in porcine growing oocytes
    Takanori Nishimura
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Reprod Dev 55:553-7. 2009
    ..These results strongly suggest that an insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure of small oocytes in pigs...
  4. pmc Transcriptome analysis reveals an unexpected role of a collagen tyrosine kinase receptor gene, Ddr2, as a regulator of ovarian function
    Hirokazu Matsumura
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo, Japan
    Physiol Genomics 39:120-9. 2009
    ..Taken together, our convergent data signify DDR2 as a novel critical player in ovarian function, which acts upon classical endocrine pathways in somatic, rather than germline, cells...
  5. ncbi Analyses of the involvement of PKA regulation mechanism in meiotic incompetence of porcine growing oocytes
    Takanori Nishimura
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Science, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Biol Reprod 87:53. 2012
    ....
  6. doi CDK7 and CCNH are components of CDK-activating kinase and are required for meiotic progression of pig oocytes
    Wataru Fujii
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Science, University of Tokyo, Tokyo, Japan
    Biol Reprod 85:1124-32. 2011
    ..These results suggest that CDK7 and CCNH activate CDC2 by T161 phosphorylation and make up CAK, which is required for normal meiotic progression during porcine oocyte maturation...
  7. ncbi Identification of whey acidic protein (WAP) in dog milk
    Mami Seki
    Laboratory of Applied Genetics, The University of Tokyo, Japan
    Exp Anim 61:67-70. 2012
    ..Biochemical analysis of milk protein by reverse-phase HPLC and Western blotting demonstrated the presence of WAP in dog milk...
  8. doi Functions of FZR1 and CDC20, activators of the anaphase-promoting complex, during meiotic maturation of swine oocytes
    Tadashi Yamamuro
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Biol Reprod 79:1202-9. 2008
    ....
  9. doi Porcine Aurora A accelerates Cyclin B and Mos synthesis and promotes meiotic resumption of porcine oocytes
    Yukio Nishimura
    Department of Animal Resource Sciences, Graduate School of Agricultural Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Anim Reprod Sci 113:114-24. 2009
    ..In addition, we identified the inhibitory phosphorylation sites of porcine Aurora A, and indicate the presence of phosphorylation-dependent regulation mechanisms in mammalian Aurora A...
  10. ncbi Whey acidic protein (WAP) regulates the proliferation of mammary epithelial cells by preventing serine protease from degrading laminin
    Naoko Nukumi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Cell Physiol 213:793-800. 2007
    ..We concluded that WAP plays some role in regulating the proliferation of mammary epithelial cells by preventing elastase-type serine protease from carrying out laminin degradation and thereby suppressing the MAP kinase signal pathway...
  11. doi Histone exchange activity and its correlation with histone acetylation status in porcine oocytes
    Tsutomu Endo
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Science, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Reproduction 141:397-405. 2011
    ....
  12. pmc A novel ENU-induced mutation, peewee, causes dwarfism in the mouse
    Bokryeon Lee
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo, 113 8657, Japan
    Mamm Genome 20:404-13. 2009
    ..Detailed analysis of peewee mice might provide novel molecular insights into the complex mechanisms regulating body growth...
  13. ncbi Bacteriostatic activity of Whey Acidic Protein (WAP)
    Tokuko Iwamori
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
    J Vet Med Sci 72:621-5. 2010
    ..The bacteriostatic activity of WAP was highest at pH 6.6 and was not affected by the presence of 150 mM NaCl. A scanning electron micrograph of bacteria treated with WAP exhibited the disruption of the bacterial cell walls...
  14. ncbi Meiotic resumption of porcine immature oocytes is prevented by ooplasmic Gsalpha functions
    Marie Morikawa
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Science, University of Tokyo, Tokyo, Japan
    J Reprod Dev 53:1151-7. 2007
    ....
  15. doi Discoidin domain receptor 2 (DDR2) regulates proliferation of endochondral cells in mice
    Ikuma Kawai
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo 113 8657, Japan
    Biochem Biophys Res Commun 427:611-7. 2012
    ..Taken together, our data demonstrated that DDR2 might play a local and essential role in the proliferation of chondrocytes...
  16. ncbi Critical effect of pigWee1B on the regulation of meiotic resumption in porcine immature oocytes
    Takuma Shimaoka
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Cell Cycle 8:2375-84. 2009
    ....
  17. ncbi Reduction of tumorigenesis and invasion of human breast cancer cells by whey acidic protein (WAP)
    Naoko Nukumi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Cancer Lett 252:65-74. 2007
    ..These data suggest that WAP has a protease-inhibitory function on the progression of breast cancer cells. It is therefore possible to utilize WAP as therapeutic protein against tumorigenesis of breast cancer...
  18. pmc Repeatable construction method for engineered zinc finger nuclease based on overlap extension PCR and TA-cloning
    Wataru Fujii
    Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan
    PLoS ONE 8:e59801. 2013
    ..This method, which enables the construction of intended ZFNs repeatedly and inexpensively in a short period of time, should contribute to the advancement of ZFN technology...
  19. ncbi Preimplantation-embryo-specific cell-cycle regulation is attributable to a low expression of retinoblastoma protein rather than its phosphorylation
    Asuka Egashira
    Graduate School of Agriculture and Life Sciences, University of Tokyo, Tokyo, Japan
    J Reprod Dev 57:492-9. 2011
    ..Moreover, the present study indicates the similarity between preimplantation embryos and cancer cells, which p16(INK4a) expression does not arrest at the G1 phase...
  20. ncbi Investigation of the fate of Sry-expressing cells using an in vivo Cre/loxP system
    Masanori Ito
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Japan
    Dev Growth Differ 48:41-7. 2006
    ..These analyses indicate that cells expressing Sry-inducing factors in female fetal gonads become granulosa cells...
  21. ncbi Mos and the mitogen-activated protein kinase do not show cytostatic factor activity in early mouse embryos
    Koji Kashima
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Science, University of Tokyo, Japan
    J Reprod Dev 53:1175-82. 2007
    ..The present study indicates that there are large physiological differences between early mouse embryos and mouse oocytes and that CSF arrest of mouse eggs in mitosis should be discussed separately from that in meiosis...
  22. doi Nuclear histone deacetylases are not required for global histone deacetylation during meiotic maturation in porcine oocytes
    Tsutomu Endo
    Laboratory of Applied Genetics, Graduate School of Agriculture and Life Science, University of Tokyo, Tokyo 113 8657, Japan
    Biol Reprod 78:1073-80. 2008
    ..These results revealed that nuclear contents, including class I HDACs, are not required for the global histone deacetylation during meiosis, and that cytoplasmic HDACs other than class I are responsible for this process...
  23. doi Discoidin domain receptor 2 (DDR2) regulates body size and fat metabolism in mice
    Ikuma Kawai
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo, 113 8657, Japan
    Transgenic Res 23:165-75. 2014
    ..Taken together, our data demonstrated that DDR2 might play a systemic role in the regulation of body size thorough skeletal formation and fat metabolism. ..
  24. ncbi Regulation of embryonic size in early mouse development in vitro culture system
    Tomoka Hisaki
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo 113 8657, Japan
    Zygote 22:340-7. 2014
    ..In conclusion, our results indicated that embryos have some ways in which to regulate their own size in mouse early development. ..
  25. ncbi Expression profiling of tetraploid mouse embryos in the developmental stages using a cDNA microarray analysis
    Jutaro Kawaguchi
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo, Japan
    J Reprod Dev 55:670-5. 2009
    ....
  26. ncbi Porcine SPDYA2 (RINGO A2) stimulates CDC2 activity and accelerates meiotic maturation of porcine oocytes
    Sachi Kume
    Department of Animal Resource Sciences, Graduate School of Agricultural Sciences, University of Tokyo, Tokyo 113 8657, Japan
    Biol Reprod 76:440-7. 2007
    ..These results suggest that pigSPDYA2 has important roles on meiotic maturation of porcine oocytes and that the rapid degradation of SPDY was necessary for the normal maturation of oocytes...
  27. ncbi Aberrant development of mammary glands, but precocious expression of beta-casein in transgenic females ubiquitously expressing whey acidic protein transgene
    Tokuko Iwamori
    Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan
    J Reprod Dev 51:579-92. 2005
    ..In vitro experiments using HC11 cells with forced expression of exogenous WAP demonstrated the inhibitory function of WAP on proliferation of mammary epithelial cells...
  28. ncbi Expression of Prnp mRNA (prion protein gene) in mouse spermatogenic cells
    Masahiko Fujisawa
    Department of Veterinary Anatomy, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, Japan
    J Reprod Dev 50:565-70. 2004
    ..These results suggest that Prnp may be involved in germ cell differentiation during mammalian spermatogenesis...
  29. ncbi Tetraploid cells of enhanced green fluorescent protein transgenic mice in tetraploid/diploid-chimeric embryos
    Naomi Ishiguro
    Laboratory of Veterinary Anatomy, Iwate University, Japan
    J Reprod Dev 51:567-72. 2005
    ..This study demonstrated the utility of EGFP transgenic mouse embryos for relatively easy and noninvasive study of the sequential distribution of cells in chimeric embryos...