Research Topics
Genomes and Genes | Kiyoshi KanoSummaryAffiliation: University of Tokyo Country: Japan Publications
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Publications
Discoidin domain receptor 2 (DDR2) is required for maintenance of spermatogenesis in male miceKiyoshi Kano
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
Mol Reprod Dev 77:29-37. 2010..DDR2 was expressed in the Leydig cells of adult wild-type male mice. In conclusion, our results indicated that DDR2 signaling plays a critical role in the maintenance of male spermatogenesis...
A novel dwarfism with gonadal dysfunction due to loss-of-function allele of the collagen receptor gene, Ddr2, in the mouseKiyoshi Kano
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo 113 8657, Japan
Mol Endocrinol 22:1866-80. 2008..Taken together, our results indicate that the absence of DDR2 leads to growth retardation and gonadal dysfunction due to peripheral defects in hormonal-responsive pathways in slie mice...
Insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure in porcine growing oocytesTakanori Nishimura
Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan
J Reprod Dev 55:553-7. 2009..These results strongly suggest that an insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure of small oocytes in pigs...- Transcriptome analysis reveals an unexpected role of a collagen tyrosine kinase receptor gene, Ddr2, as a regulator of ovarian functionHirokazu Matsumura
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo, Japan
Physiol Genomics 39:120-9. 2009..Taken together, our convergent data signify DDR2 as a novel critical player in ovarian function, which acts upon classical endocrine pathways in somatic, rather than germline, cells... - Analyses of the involvement of PKA regulation mechanism in meiotic incompetence of porcine growing oocytesTakanori Nishimura
Laboratory of Applied Genetics, Graduate School of Agriculture and Life Science, University of Tokyo, Bunkyo ku, Tokyo, Japan
Biol Reprod 87:53. 2012.... - CDK7 and CCNH are components of CDK-activating kinase and are required for meiotic progression of pig oocytesWataru Fujii
Laboratory of Applied Genetics, Graduate School of Agriculture and Life Science, University of Tokyo, Tokyo, Japan
Biol Reprod 85:1124-32. 2011..These results suggest that CDK7 and CCNH activate CDC2 by T161 phosphorylation and make up CAK, which is required for normal meiotic progression during porcine oocyte maturation... - Identification of whey acidic protein (WAP) in dog milkMami Seki
Laboratory of Applied Genetics, The University of Tokyo, Japan
Exp Anim 61:67-70. 2012..Biochemical analysis of milk protein by reverse-phase HPLC and Western blotting demonstrated the presence of WAP in dog milk... - Functions of FZR1 and CDC20, activators of the anaphase-promoting complex, during meiotic maturation of swine oocytesTadashi Yamamuro
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
Biol Reprod 79:1202-9. 2008.... - Porcine Aurora A accelerates Cyclin B and Mos synthesis and promotes meiotic resumption of porcine oocytesYukio Nishimura
Department of Animal Resource Sciences, Graduate School of Agricultural Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
Anim Reprod Sci 113:114-24. 2009..In addition, we identified the inhibitory phosphorylation sites of porcine Aurora A, and indicate the presence of phosphorylation-dependent regulation mechanisms in mammalian Aurora A... - Whey acidic protein (WAP) regulates the proliferation of mammary epithelial cells by preventing serine protease from degrading lamininNaoko Nukumi
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
J Cell Physiol 213:793-800. 2007..We concluded that WAP plays some role in regulating the proliferation of mammary epithelial cells by preventing elastase-type serine protease from carrying out laminin degradation and thereby suppressing the MAP kinase signal pathway... - A novel ENU-induced mutation, peewee, causes dwarfism in the mouseBokryeon Lee
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo, 113 8657, Japan
Mamm Genome 20:404-13. 2009..Detailed analysis of peewee mice might provide novel molecular insights into the complex mechanisms regulating body growth... - Histone exchange activity and its correlation with histone acetylation status in porcine oocytesTsutomu Endo
Laboratory of Applied Genetics, Graduate School of Agriculture and Life Science, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
Reproduction 141:397-405. 2011.... - Bacteriostatic activity of Whey Acidic Protein (WAP)Tokuko Iwamori
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
J Vet Med Sci 72:621-5. 2010..The bacteriostatic activity of WAP was highest at pH 6.6 and was not affected by the presence of 150 mM NaCl. A scanning electron micrograph of bacteria treated with WAP exhibited the disruption of the bacterial cell walls... - Meiotic resumption of porcine immature oocytes is prevented by ooplasmic Gsalpha functionsMarie Morikawa
Laboratory of Applied Genetics, Graduate School of Agriculture and Life Science, University of Tokyo, Tokyo, Japan
J Reprod Dev 53:1151-7. 2007.... - Reduction of tumorigenesis and invasion of human breast cancer cells by whey acidic protein (WAP)Naoko Nukumi
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
Cancer Lett 252:65-74. 2007..These data suggest that WAP has a protease-inhibitory function on the progression of breast cancer cells. It is therefore possible to utilize WAP as therapeutic protein against tumorigenesis of breast cancer... - Critical effect of pigWee1B on the regulation of meiotic resumption in porcine immature oocytesTakuma Shimaoka
Laboratory of Applied Genetics, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
Cell Cycle 8:2375-84. 2009.... - Preimplantation-embryo-specific cell-cycle regulation is attributable to a low expression of retinoblastoma protein rather than its phosphorylationAsuka Egashira
Graduate School of Agriculture and Life Sciences, University of Tokyo, Tokyo, Japan
J Reprod Dev 57:492-9. 2011..Moreover, the present study indicates the similarity between preimplantation embryos and cancer cells, which p16(INK4a) expression does not arrest at the G1 phase... - Investigation of the fate of Sry-expressing cells using an in vivo Cre/loxP systemMasanori Ito
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Japan
Dev Growth Differ 48:41-7. 2006..These analyses indicate that cells expressing Sry-inducing factors in female fetal gonads become granulosa cells... - Mos and the mitogen-activated protein kinase do not show cytostatic factor activity in early mouse embryosKoji Kashima
Laboratory of Applied Genetics, Graduate School of Agriculture and Life Science, University of Tokyo, Japan
J Reprod Dev 53:1175-82. 2007..The present study indicates that there are large physiological differences between early mouse embryos and mouse oocytes and that CSF arrest of mouse eggs in mitosis should be discussed separately from that in meiosis... - Nuclear histone deacetylases are not required for global histone deacetylation during meiotic maturation in porcine oocytesTsutomu Endo
Laboratory of Applied Genetics, Graduate School of Agriculture and Life Science, University of Tokyo, Tokyo 113 8657, Japan
Biol Reprod 78:1073-80. 2008..These results revealed that nuclear contents, including class I HDACs, are not required for the global histone deacetylation during meiosis, and that cytoplasmic HDACs other than class I are responsible for this process... - Expression profiling of tetraploid mouse embryos in the developmental stages using a cDNA microarray analysisJutaro Kawaguchi
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo, Japan
J Reprod Dev 55:670-5. 2009.... - Aberrant development of mammary glands, but precocious expression of beta-casein in transgenic females ubiquitously expressing whey acidic protein transgeneTokuko Iwamori
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan
J Reprod Dev 51:579-92. 2005..In vitro experiments using HC11 cells with forced expression of exogenous WAP demonstrated the inhibitory function of WAP on proliferation of mammary epithelial cells... - Porcine SPDYA2 (RINGO A2) stimulates CDC2 activity and accelerates meiotic maturation of porcine oocytesSachi Kume
Department of Animal Resource Sciences, Graduate School of Agricultural Sciences, University of Tokyo, Tokyo 113 8657, Japan
Biol Reprod 76:440-7. 2007..These results suggest that pigSPDYA2 has important roles on meiotic maturation of porcine oocytes and that the rapid degradation of SPDY was necessary for the normal maturation of oocytes... - Discoidin domain receptor 2 (DDR2) regulates proliferation of endochondral cells in miceIkuma Kawai
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo 113 8657, Japan
Biochem Biophys Res Commun 427:611-7. 2012..Taken together, our data demonstrated that DDR2 might play a local and essential role in the proliferation of chondrocytes... - Expression of Prnp mRNA (prion protein gene) in mouse spermatogenic cellsMasahiko Fujisawa
Department of Veterinary Anatomy, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, Japan
J Reprod Dev 50:565-70. 2004..These results suggest that Prnp may be involved in germ cell differentiation during mammalian spermatogenesis... - Tetraploid cells of enhanced green fluorescent protein transgenic mice in tetraploid/diploid-chimeric embryosNaomi Ishiguro
Laboratory of Veterinary Anatomy, Iwate University, Japan
J Reprod Dev 51:567-72. 2005..This study demonstrated the utility of EGFP transgenic mouse embryos for relatively easy and noninvasive study of the sequential distribution of cells in chimeric embryos...