Y Kanda

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Evaluation of the validity of preemptive therapy against cytomegalovirus disease based on antigenemia assay with a cutoff of 20 positive cells per two slides
    Kana Sakamoto
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    PLoS ONE 8:e73754. 2013
  2. doi request reprint Changes in the clinical impact of high-risk human leukocyte antigen allele mismatch combinations on the outcome of unrelated bone marrow transplantation
    Yoshinobu Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan Electronic address
    Biol Blood Marrow Transplant 20:526-35. 2014
  3. doi request reprint Protection of ovarian function by two distinct methods of ovarian shielding for young female patients who receive total body irradiation
    Yoshinobu Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, 1 847 Amanuma Omiya ku, Saitama, Saitama, 330 8503, Japan
    Ann Hematol 93:287-92. 2014
  4. doi request reprint Impact of a single human leucocyte antigen (HLA) allele mismatch on the outcome of unrelated bone marrow transplantation over two time periods. A retrospective analysis of 3003 patients from the HLA Working Group of the Japan Society for Blood and Marrow
    Yoshinobu Kanda
    Division of Haematology, Saitama Medical Centre, Jichi Medical University, Saitama, Japan
    Br J Haematol 161:566-77. 2013
  5. doi request reprint In vivo T-cell depletion with alemtuzumab in allogeneic hematopoietic stem cell transplantation: Combined results of two studies on aplastic anemia and HLA-mismatched haploidentical transplantation
    Yoshinobu Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Am J Hematol 88:294-300. 2013
  6. pmc Investigation of the freely available easy-to-use software 'EZR' for medical statistics
    Y Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Bone Marrow Transplant 48:452-8. 2013
  7. doi request reprint Allo-SCT using reduced-intensity conditioning against advanced pancreatic cancer: a Japanese survey
    Y Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, 1 847 Amanuma, Omiya ku, Saitama City, Saitama, Japan
    Bone Marrow Transplant 42:99-103. 2008
  8. doi request reprint Multicenter prospective trial evaluating the tolerability of imatinib for Japanese patients with chronic myelogenous leukemia in the chronic phase: does body weight matter?
    Yoshinobu Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Am J Hematol 83:835-9. 2008
  9. doi request reprint A randomized controlled trial of plasma real-time PCR and antigenemia assay for monitoring CMV infection after unrelated BMT
    Y Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Bone Marrow Transplant 45:1325-32. 2010
  10. ncbi request reprint Effect of blood cyclosporine concentration on the outcome of hematopoietic stem cell transplantation from an HLA-matched sibling donor
    Yoshinobu Kanda
    Department of Hematology, Cell Therapy and Transplantation Medicine, University of Tokyo, Graduate School of Medicine and Hospital, Tokyo, Japan
    Am J Hematol 81:838-44. 2006

Collaborators

Detail Information

Publications76

  1. pmc Evaluation of the validity of preemptive therapy against cytomegalovirus disease based on antigenemia assay with a cutoff of 20 positive cells per two slides
    Kana Sakamoto
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    PLoS ONE 8:e73754. 2013
    ..However, the appropriate threshold of antigenemia-positive cells for deciding when to start GCV remains unclear...
  2. doi request reprint Changes in the clinical impact of high-risk human leukocyte antigen allele mismatch combinations on the outcome of unrelated bone marrow transplantation
    Yoshinobu Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan Electronic address
    Biol Blood Marrow Transplant 20:526-35. 2014
    ..Unrelated transplantation with a single HR-MM could be a viable option in the absence of a matched unrelated donor or an unrelated donor with a single LR-MM...
  3. doi request reprint Protection of ovarian function by two distinct methods of ovarian shielding for young female patients who receive total body irradiation
    Yoshinobu Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, 1 847 Amanuma Omiya ku, Saitama, Saitama, 330 8503, Japan
    Ann Hematol 93:287-92. 2014
    ..In conclusion, ovarian shielding with both methods strongly protected ovarian function. However, we should continue to monitor the relapse rate among patients who undergo this procedure...
  4. doi request reprint Impact of a single human leucocyte antigen (HLA) allele mismatch on the outcome of unrelated bone marrow transplantation over two time periods. A retrospective analysis of 3003 patients from the HLA Working Group of the Japan Society for Blood and Marrow
    Yoshinobu Kanda
    Division of Haematology, Saitama Medical Centre, Jichi Medical University, Saitama, Japan
    Br J Haematol 161:566-77. 2013
    ..In conclusion, the impact of a single HLA allele mismatch changed over time. In the recent cohort, the negative impact of HLA-DRB1 and -C mismatches became apparent...
  5. doi request reprint In vivo T-cell depletion with alemtuzumab in allogeneic hematopoietic stem cell transplantation: Combined results of two studies on aplastic anemia and HLA-mismatched haploidentical transplantation
    Yoshinobu Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Am J Hematol 88:294-300. 2013
    ..However, the use of a lower dose of alemtuzumab should be explored in future studies to accelerate immune recovery after HSCT...
  6. pmc Investigation of the freely available easy-to-use software 'EZR' for medical statistics
    Y Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Bone Marrow Transplant 48:452-8. 2013
    ..jichi.ac.jp/saitama-sct/SaitamaHP.files/statmed.html) and runs on both Windows (Microsoft Corporation, USA) and Mac OS X (Apple, USA). This report provides instructions for the installation and operation of EZR...
  7. doi request reprint Allo-SCT using reduced-intensity conditioning against advanced pancreatic cancer: a Japanese survey
    Y Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, 1 847 Amanuma, Omiya ku, Saitama City, Saitama, Japan
    Bone Marrow Transplant 42:99-103. 2008
    ..Patients who developed chronic GVHD tended to survive longer than those who did not. These findings support the investigation of a novel treatment strategy to enhance the immunological effect against pancreatic cancer...
  8. doi request reprint Multicenter prospective trial evaluating the tolerability of imatinib for Japanese patients with chronic myelogenous leukemia in the chronic phase: does body weight matter?
    Yoshinobu Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Am J Hematol 83:835-9. 2008
    ....
  9. doi request reprint A randomized controlled trial of plasma real-time PCR and antigenemia assay for monitoring CMV infection after unrelated BMT
    Y Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Bone Marrow Transplant 45:1325-32. 2010
    ..However, the appropriateness of the threshold may be different by the methodology used, and therefore, it is difficult to generalize...
  10. ncbi request reprint Effect of blood cyclosporine concentration on the outcome of hematopoietic stem cell transplantation from an HLA-matched sibling donor
    Yoshinobu Kanda
    Department of Hematology, Cell Therapy and Transplantation Medicine, University of Tokyo, Graduate School of Medicine and Hospital, Tokyo, Japan
    Am J Hematol 81:838-44. 2006
    ..35%, P = 0.036). We concluded that the blood CsA concentration at peri-engraftment period may be important in preventing acute GVHD...
  11. ncbi request reprint Effect of conditioning regimen on the outcome of bone marrow transplantation from an unrelated donor
    Yoshinobu Kanda
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Hongo, Tokyo, Japan
    Biol Blood Marrow Transplant 11:881-9. 2005
    ..48; P = .0003) and inferior survival (RR, 1.45; P < .0001). The results of this retrospective study suggested that the Cy-TBI regimen was superior to other regimens in unrelated BMT...
  12. ncbi request reprint In vivo alemtuzumab enables haploidentical human leukocyte antigen-mismatched hematopoietic stem-cell transplantation without ex vivo graft manipulation
    Yoshinobu Kanda
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Hongo, Tokyo, Japan
    Transplantation 79:1351-7. 2005
    ..This study evaluates the safety of unmanipulated peripheral blood stem-cell transplantation from two or three loci-mismatched related donors using alemtuzumab in vivo...
  13. ncbi request reprint Prophylactic action of oral fluconazole against fungal infection in neutropenic patients. A meta-analysis of 16 randomized, controlled trials
    Y Kanda
    Department of Hematology, International Medical Center of Japan, Tokyo, Japan
    Cancer 89:1611-25. 2000
    ..Therefore, the authors performed a meta-analysis to evaluate the efficacy of fluconazole prophylaxis during chemotherapy-induced neutropenia...
  14. ncbi request reprint Effect of graft-versus-host disease on the outcome of bone marrow transplantation from an HLA-identical sibling donor using GVHD prophylaxis with cyclosporin A and methotrexate
    Y Kanda
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Japan
    Leukemia 18:1013-9. 2004
    ..In conclusion, the therapeutic window between decreased relapse and increased transplant-related mortality due to the development of GVHD appeared to be very narrow...
  15. ncbi request reprint Treatment of deep vein thrombosis using temporary vena caval filters after allogeneic bone marrow transplantation
    Y Kanda
    Department of Hematology, International Medical Center of Japan, Tokyo
    Leuk Lymphoma 38:429-33. 2000
    ..We considered that temporary vena caval filter is a safe and useful device to prevent pulmonary embolism after DVT in BMT recipients...
  16. ncbi request reprint Pyogenic granuloma of the tongue early after allogeneic bone marrow transplantation for multiple myeloma
    Y Kanda
    Department of Hematology, International Medical Center of Japan, Tokyo
    Leuk Lymphoma 37:445-9. 2000
    ..Regimen-related mucositis, oral acute GVHD, the administration of cyclosporine A, and the preexisting macroglossia might be responsible for the formation of granuloma...
  17. ncbi request reprint Lack of correlation between clinical characteristics and serum soluble Fas ligand levels in patients with multiple myeloma
    Y Kanda
    Department of Hematology, International Medical Center of Japan, Tokyo
    Leuk Lymphoma 40:351-6. 2001
    ..The serum sFasL levels were not affected by the disease status, serum monoclonal protein levels, or other prognostic factors. We could not determine whether the expression of FasL is involved in the poor clinical course of the disease...
  18. ncbi request reprint Successful application of nonmyeloablative transplantation for paroxysmal nocturnal hemoglobinuria
    K Suenaga
    Stem Cell Transplant Unit, National Cancer Center Hospital, Tokyo, Japan
    Exp Hematol 29:639-42. 2001
    ..CONCLUSIONS: NST may become a safe and curative approach in patients with PNH. Further studies are needed to establish the role of NST for treatment of PNH...
  19. ncbi request reprint Early onset Pneumocystis carinii pneumonia after allogeneic peripheral blood stem cell transplantation
    T Saito
    Hematopoietic Stem Cell Transplantation Unit, National Cancer Center Hospital, Tokyo, Japan
    Am J Hematol 67:206-9. 2001
    ..Intravenous TMP/SMX failed to improve the lesion. This is the earliest onset PCP in the literature after HSCT despite the prophylactic administration of TMP/SMX before transplant...
  20. ncbi request reprint Immune reconstitution following reduced-intensity transplantation with cladribine, busulfan, and antithymocyte globulin: serial comparison with conventional myeloablative transplantation
    T Saito
    Hematopoietic Stem Cell Transplantation Unit, National Cancer Center Hospital, Chuo Ku, Tokyo, Japan
    Bone Marrow Transplant 32:601-8. 2003
    ..We concluded that our RIST regimen might delay laboratory-evaluated T-cell immune reconstitution compared to CST; however, the observed setbacks did not directly translate into clinically significant increases in infectious episodes...
  21. ncbi request reprint Pre-emptive therapy against cytomegalovirus (CMV) disease guided by CMV antigenemia assay after allogeneic hematopoietic stem cell transplantation: a single-center experience in Japan
    Y Kanda
    Stem Cell Transplant Unit, National Cancer Center Hospital, Tokyo, Japan
    Bone Marrow Transplant 27:437-44. 2001
    ..We concluded that antigenemia-guided pre-emptive therapy with a decreased dose of ganciclovir and response-oriented dose adjustment might be appropriate to decrease the toxicity of ganciclovir without increasing the risk of CMV disease...
  22. ncbi request reprint High-grade cytomegalovirus antigenemia after hematopoietic stem cell transplantation
    Y Asano-Mori
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Tokyo, Japan
    Bone Marrow Transplant 36:813-9. 2005
    ..Although CMV disease frequently developed in HG-antigenemia patients, antiviral therapy could prevent a fatal outcome...
  23. ncbi request reprint Prediction of transplant-related complications by C-reactive protein levels before hematopoietic SCT
    M Sato
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Bone Marrow Transplant 48:698-702. 2013
    ..27, P=0.0018). On the other hand, the baseline CRP level did not predict infectious events. These findings suggested that CRP levels before conditioning may be a useful predictive biomarker for poor survival...
  24. ncbi request reprint Male predominance among Japanese adult patients with late-onset hemorrhagic cystitis after hematopoietic stem cell transplantation
    Y Asano
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
    Bone Marrow Transplant 32:1175-9. 2003
    ..Male predominance was detected in LHC after HSCT, as has been previously shown in children with AdV-induced acute HC. The detection of AdV DNA in serum did not predict a poor outcome...
  25. ncbi request reprint Long-term low-dose acyclovir against varicella-zoster virus reactivation after allogeneic hematopoietic stem cell transplantation
    Y Kanda
    Stem Cell Transplant Unit, National Cancer Center Hospital, University of Tokyo, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
    Bone Marrow Transplant 28:689-92. 2001
    ..Resumption of acyclovir upon restarting immunosuppressive therapy might be important for the further prevention of VZV reactivation. The benefit of long-term low-dose acyclovir should be confirmed prospectively...
  26. doi request reprint L-index as a novel index to evaluate both the intensity and duration of lymphopenia after allogeneic hematopoietic stem cell transplantation
    S I Kimura
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Transpl Infect Dis 14:364-73. 2012
    ..In conclusion, both the intensity and duration of lymphopenia in early phase after HSCT evaluated on the basis of L-index(30) showed significant association with CMV reactivation...
  27. ncbi request reprint Predictors for severe cardiac complications after hematopoietic stem cell transplantation
    M Sakata-Yanagimoto
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Bone Marrow Transplant 33:1043-7. 2004
    ..We conclude that the cumulative dose of anthracyclines is the most potent predictor of cardiac complications and the administration of anthracyclines should be avoided within two months before transplantation...
  28. ncbi request reprint Increased incidence of acute graft-versus-host disease with the continuous infusion of cyclosporine A compared to twice-daily infusion
    N Ogawa
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Bone Marrow Transplant 33:549-52. 2004
    ..039), but not in standard-risk patients (72 vs 80%, P=0.45). CIF of CsA with a target level of 250-400 ng/ml may not be appropriate for GVHD prophylaxis in standard-risk patients...
  29. ncbi request reprint Clinical and pathologic findings in 52 consecutively autopsied cases with multiple myeloma
    K Oshima
    Department of Hematology, International Medical Center of Japan, Tokyo, Japan
    Am J Hematol 67:1-5. 2001
    ..Advances in the anticancer and antimicrobial chemotherapies might have decreased deaths due to myeloma itself or infection...
  30. ncbi request reprint Computed tomographic scan of the chest, latex agglutination test and plasma (1AE3)-beta-D-glucan assay in early diagnosis of invasive pulmonary aspergillosis: a prospective study of 215 patients
    M Kami
    Department of Hematology, Toranomon Hospital, 2 2 2, Toranomon, Minato ku, Tokyo 105 8470, Japan
    Haematologica 85:745-52. 2000
    ....
  31. ncbi request reprint Clinical significance of cytomegalovirus (CMV) antigenemia in the prediction and diagnosis of CMV gastrointestinal disease after allogeneic hematopoietic stem cell transplantation
    T Mori
    Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Bone Marrow Transplant 33:431-4. 2004
    ..8 x 10(4) copies/ml plasma). We conclude that CMV antigenemia testing has limited value in prediction or early diagnosis of CMV-GI disease, and that real-time PCR could have a more diagnostic significance...
  32. ncbi request reprint Cardiac complications after haploidentical HLA-mismatched hematopoietic stem cell transplantation using in vivo alemtuzumab
    K Oshima
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
    Bone Marrow Transplant 36:821-4. 2005
    ..Patient selection and close monitoring of cardiac function may be important in HLA-mismatched HSCT using in vivo alemtuzumab...
  33. ncbi request reprint Acute adrenal failure associated with fluconazole after administration of high-dose cyclophosphamide
    S Shibata
    Department of Hematology, Toranomon Hospital, Tokyo, Japan
    Am J Hematol 66:303-5. 2001
    ..This case demonstrates that prophylactic use of fluconazole can cause adrenal insufficiency...
  34. ncbi request reprint Possible clinical benefits of the use of peripheral blood stem cells over bone marrow in the allogeneic transplantation setting for the treatment of childhood leukemia
    H Matsubara
    Pediatric Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 31:30-4. 2001
    ..The risk of chronic GVHD may need to be balanced against a possible graft-versus-leukemia benefit in patients at higher risk of leukemic relapse...
  35. ncbi request reprint Myeloablative allogeneic hematopoietic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia in adults: significant roles of total body irradiation and chronic graft-versus-host disease
    M Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Bone Marrow Transplant 36:867-72. 2005
    ..Thus, patients who developed extensive chronic GVHD had better survivals (P = 0.0217), and those who developed grade III-IV acute GVHD had worse survivals (P = 0.0023) than did the others...
  36. ncbi request reprint Clinical value of serial measurement of serum C-reactive protein level in neutropenic patients
    K Yonemori
    Department of Hematology, International Medical Center of Japan, Tokyo
    Leuk Lymphoma 41:607-14. 2001
    ..60. In conclusion, serial measurement of CRP was considered to be not useful to predict fever within three days, or to differentiate the types of infection...
  37. ncbi request reprint Tacrolimus instead of cyclosporine used for prophylaxis against graft-versus-host disease improves outcome after hematopoietic stem cell transplantation from unrelated donors, but not from HLA-identical sibling donors: a nationwide survey conducted in Jap
    M Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Bone Marrow Transplant 34:331-7. 2004
    ..62, 95% CI: 1.23-2.14, P=0.0007 for OS). This superiority of FK506 was not observed in SIB-HSCT cases. These findings indicate that the use of FK506 instead of CSP for GVHD prophylaxis is beneficial for patients undergoing UD-HSCT...
  38. ncbi request reprint The role of HLA-matched unrelated transplantation in adult patients with Ph chromosome-negative ALL in first remission. A decision analysis
    S Kako
    Division of Hematology, Department of Internal Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Bone Marrow Transplant 48:1077-83. 2013
    ..Unrelated transplantation in CR1 improves the long-term survival probability in patients who lack an HLA-matched sibling. However, recent improvements in treatment strategies may change this result. ..
  39. doi request reprint A decision analysis of allogeneic hematopoietic stem cell transplantation in adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in first remission who have an HLA-matched sibling donor
    S Kako
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Leukemia 25:259-65. 2011
    ..9 vs 31.7% in the whole population). To improve the probability of long-term survival, allogeneic HSCT in first remission is recommended for patients who have an HLA-matched sibling...
  40. doi request reprint One-year low-dose valacyclovir as prophylaxis for varicella zoster virus disease after allogeneic hematopoietic stem cell transplantation. A prospective study of the Japan Hematology and Oncology Clinical Study Group
    K Oshima
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Transpl Infect Dis 12:421-7. 2010
    ..All patients responded to the therapeutic dose of VCV or ACV. One-year low-dose VCV can be safely and effectively administered for the prevention of VZV disease after allogeneic HSCT...
  41. ncbi request reprint Comparison between reduced intensity and conventional myeloablative allogeneic stem-cell transplantation in patients with hematologic malignancies aged between 50 and 59 years
    R Kojima
    Hematopoietic Stem Cell Transplantation Unit, The National Cancer Center Hospital, and Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Japan
    Bone Marrow Transplant 36:667-74. 2005
    ..The low relapse rates following RIST suggest a strong antitumor activity through allogeneic immunity...
  42. ncbi request reprint Pharmacokinetics of CsA during the switch from continuous intravenous infusion to oral administration after allogeneic hematopoietic stem cell transplantation
    S Kimura
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Bone Marrow Transplant 45:1088-94. 2010
    ..To obtain a similar AUC, the target trough concentrations during twice-daily oral administration should be halved compared with the target concentration during continuous infusion...
  43. ncbi request reprint Serum levels of soluble interleukin-2 receptor after bone marrow transplantation: a true marker of acute graft-versus-host disease
    M Kami
    Dept of Hematology, Toranomon Hospital, Tokyo, Japan
    Leuk Lymphoma 38:533-40. 2000
    ..Some factors other than GVHD contribute to the elevation of serum sIL-2R levels, and we should recognize the limitations of the measurement of this cytokine...
  44. ncbi request reprint A high serum-soluble interleukin-2 receptor level is associated with a poor outcome of aggressive non-Hodgkin's lymphoma
    N Niitsu
    First Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
    Eur J Haematol 66:24-30. 2001
    ..In conclusion, the present findings established that the sIL-2R level is a significant independent prognostic factor in patients with aggressive NHL...
  45. ncbi request reprint Primary cutaneous aspergillosis caused by Aspergillus ustus following reduced-intensity stem cell transplantation
    K Nakai
    Hematopoietic Stem Cell Transplant Unit, National Cancer Center Hospital, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo, 105 0045, Japan
    Ann Hematol 81:593-6. 2002
    ..Although this is an extremely rare complication after transplantation, this case highlights that we should pay more attention to primary cutaneous aspergillosis in severely immunosuppressed patients...
  46. ncbi request reprint Reduced-intensity hematopoietic stem-cell transplantation for malignant lymphoma: a retrospective survey of 112 adult patients in Japan
    E Kusumi
    Department of Hematology, Toranomon Hospital, Tokyo, Japan
    Bone Marrow Transplant 36:205-13. 2005
    ..However, whether or not these potential benefits can be directly translated into improved patient survival should be evaluated in further studies...
  47. ncbi request reprint Monitoring cytomegalovirus infection by antigenemia assay and two distinct plasma real-time PCR methods after hematopoietic stem cell transplantation
    Y Tanaka
    Department of Hematology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Bone Marrow Transplant 30:315-9. 2002
    ..83). In conclusion, both real-time PCR methods showed a good correlation with the antigenemia assay, and could be used to monitor CMV infection after hematopoietic stem cell transplantation...
  48. ncbi request reprint Use of real-time PCR on blood samples for diagnosis of invasive aspergillosis
    M Kami
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Clin Infect Dis 33:1504-12. 2001
    ..3+/-6.6 days, those of BDG measurement by 6.5+/-4.9 days, and those of ELISA by 2.8+/-4.1 days. Real-time PCR was sensitive for IPA diagnosis, and quantitation was accurate...
  49. ncbi request reprint Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis
    T Hamaki
    Department of Hematology, Toranomon Hospital, Tokyo, Japan
    Bone Marrow Transplant 30:195-8. 2002
    ..5 h. Patients with renal failure can receive allogeneic HSCT, and a combination of melphalan, ATG and TLI may serve as an alternative to CY and ATG...
  50. ncbi request reprint Successful bone marrow transplantation for adult T-cell leukemia from a donor with oligoclonal proliferation of T-cells infected with human T-cell lymphotropic virus
    Y Kishi
    Department of Hematology, Toranomon Hospital, Tokyo, Japan
    Leuk Lymphoma 42:819-22. 2001
    ..Our experience supports the possibility of transplantation from HTLV-I positive donors...
  51. doi request reprint Hyperbilirubinemia in the early phase after allogeneic HSCT: prognostic significance of the alkaline phosphatase/total bilirubin ratio
    M Ashizawa
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama 330 8503, Japan
    Bone Marrow Transplant 48:94-8. 2013
    ..001). The ALP/TB ratio at the onset of hyperbilirubinemia may be a useful predictor for the prognosis of hyperbilirubinemia and SOS early after HSCT...
  52. ncbi request reprint Simple prognostic model for patients with multiple myeloma: a single-center study in Japan
    M Kaneko
    Department of Hematology, International Medical Center of Japan, Japan
    Ann Hematol 81:33-6. 2002
    ..In conclusion, we have established a simple prognostic model for Japanese myeloma patients only, using factors that can be determined in routine examinations without the need of subjective information...
  53. pmc Thrombin-induced p38 mitogen-activated protein kinase activation is mediated by epidermal growth factor receptor transactivation pathway
    Y Kanda
    Department of Pharmacology, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Br J Pharmacol 132:1657-64. 2001
    ..In contrast, PDGF-induced DNA synthesis was not affected by AG1478. In conclusion, these data suggest that the EGF receptor transactivation and subsequent p38 MAPK activation is required for thrombin-induced proliferation of VSMC...
  54. ncbi request reprint Preservation of ovarian function by ovarian shielding when undergoing total body irradiation for hematopoietic stem cell transplantation: a report of two successful cases
    K Nakagawa
    Department of Radiology, University of Tokyo Hospital, Tokyo, Japan
    Bone Marrow Transplant 37:583-7. 2006
    ..3, and serum estradiol was transiently detected above 20 pg/ml. The preservation of ovarian function was made possible by ovarian shielding. However, a longer follow-up is needed to know if normal pregnancy and delivery can occur...
  55. doi request reprint Single-cell T-cell receptor-β analysis of HLA-A*2402-restricted CMV- pp65-specific cytotoxic T-cells in allogeneic hematopoietic SCT
    H Nakasone
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Bone Marrow Transplant 49:87-94. 2014
    ..Patterns of clone reconstitution and phenotype would be different according to CMV reactivation. In vivo clone monitoring of CMV-CTLs could provide insight into the mechanism of immunological reconstitution following Allo-HCT. ..
  56. ncbi request reprint Recovery of Valpha24+ NKT cells after hematopoietic stem cell transplantation
    K Haraguchi
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Bone Marrow Transplant 34:595-602. 2004
    ..Our results raise the possibility that the number of Valpha24+ NKT cells could be related to the development of GVHD...
  57. ncbi request reprint Intestinal thrombotic microangiopathy following reduced-intensity umbilical cord blood transplantation
    H Narimatsu
    Department of Hematology, Toranomon Hospital, Tokyo, Japan
    Bone Marrow Transplant 36:517-23. 2005
    ..Since conventional diagnostic criteria can overlook TMA, its diagnosis requires careful examination of the gastrointestinal tract using endoscopy with biopsy...
  58. ncbi request reprint Early full donor myeloid chimerism after reduced-intensity stem cell transplantation using a combination of fludarabine and busulfan
    H Niiya
    Hematopoietic Stem Cell Transplant Unit, National Cancer Center Hospital, Tokyo, Japan
    Haematologica 86:1071-4. 2001
    ..Thus, the strategy for controlling immunosuppression after RIST should be modified according to the type of conditioning regimen applied...
  59. ncbi request reprint Reduced-intensity stem-cell transplantation for adult acute lymphoblastic leukemia: a retrospective study of 33 patients
    T Hamaki
    Department of Transfusion Medicine, Metropolitan Fuchu Hospital, Tokyo, Japan
    Bone Marrow Transplant 35:549-56. 2005
    ..9 and 30.4%, respectively. These findings suggest the presence of a graft-versus-leukemia effect for ALL. RIST for ALL is worth considering for further evaluation...
  60. ncbi request reprint A high incidence of late-onset neutropenia following rituximab-containing chemotherapy as a primary treatment of CD20-positive B-cell lymphoma: a single-institution study
    E Nitta
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Ann Oncol 18:364-9. 2007
    ..Late-onset neutropenia (LON) has been reported following rituximab-containing chemotherapy. Its incidence and risk factors, however, have not been extensively studied...
  61. doi request reprint Varicella zoster virus meningoencephalitis after allogeneic hematopoietic stem cell transplantation
    J Suzuki
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Transpl Infect Dis 14:E7-12. 2012
    ....
  62. ncbi request reprint Thyroid function after bone marrow transplantation: possible association between immune-mediated thyrotoxicosis and hypothyroidism
    M Kami
    Department of Hematology and Oncology, Faculty of Medicine, University of Tokyo, Japan
    Transplantation 71:406-11. 2001
    ..Immune-mediated thyroid injury may contribute to the development of posttransplant hypothyroidism...
  63. ncbi request reprint The diagnostic value of kappa/lambda ratios determined by flow cytometric analysis of biopsy specimens in B-cell lymphoma
    A Chizuka
    Department of Haematology, International Medical Center of Japan, Japan
    Clin Lab Haematol 24:33-6. 2002
    ..0. The specificity, sensitivity, positive and negative predictive values were 92.3%, 73.1%, 90% and 77%, respectively. We concluded that determination of LCR is a useful adjunct to pathological diagnosis...
  64. doi request reprint Low-dose acyclovir prophylaxis for the prevention of herpes simplex virus disease after allogeneic hematopoietic stem cell transplantation
    K Kawamura
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Transpl Infect Dis 15:457-65. 2013
    ..However, low-dose ACV (200 mg/day) has been shown to prevent varicella zoster virus reactivation in the middle and late phases of HSCT...
  65. doi request reprint Unrelated cord blood transplantation vs related transplantation with HLA 1-antigen mismatch in the graft-versus-host direction
    J Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Leukemia 27:286-94. 2013
    ..In conclusion, UCB and RD/1AG-MM-GVH are comparable for use as an alternative donor, except for RD/1AG-MM-GVH involving an HLA-B mismatch...
  66. ncbi request reprint Brain eicosanoid levels in spontaneously hypertensive rats after ischemia with reperfusion: leukotriene C4 as a possible cause of cerebral edema
    H Minamisawa
    Second Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Stroke 19:372-7. 1988
    ..Both inhibitors suppressed the increased leukotriene C4 and brain water contents after reperfusion. Our results indicate that leukotriene C4 is closely associated with an induction of ischemic cerebral edema...
  67. ncbi request reprint Suspected delayed immune recovery against cytomegalovirus after reduced-intensity stem cell transplantation using anti-thymocyte globulin
    K Nakai
    Stem Cell Transplant Unit, National Cancer Center Hospital, Tokyo, Japan
    Bone Marrow Transplant 29:237-41. 2002
    ..Early therapeutic intervention with ganciclovir might play a role in preventing the progression of early CMV infection to CMV disease...
  68. ncbi request reprint Successful treatment of meningoencephalitis caused by methicillin-resistant Staphylococcus aureus with intrathecal vancomycin in an allogeneic peripheral blood stem cell transplant recipient
    H Matsubara
    Divisions of Pediatric Oncology, National Cancer Hospital, Tokyo, Japan
    Bone Marrow Transplant 31:65-7. 2003
    ..We successfully cured the infection with a combination of intravenous and intrathecal vancomycin...
  69. doi request reprint Immune recovery after autologous PBSC transplantation without in vitro graft manipulation for refractory systemic lupus erythematosus
    H Wada
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Bone Marrow Transplant 46:1450-4. 2011
    ..ASCT with the reinfusion of a large number of autologous T cells did not impair the recovery of naive T cells or resetting of the immune system...
  70. ncbi request reprint Reverse seroconversion of hepatitis B virus after hematopoietic stem cell transplantation
    S Goyama
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Leuk Lymphoma 43:2159-63. 2002
    ..The use of corticosteroids, the lack of HBsAb in donor, and a decrease in serum HBsAb and HBcAb levels may predict reverse seroconversion after HSCT...
  71. ncbi request reprint FDG-PET in T-cell and NK-cell neoplasms
    S Kako
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Ann Oncol 18:1685-90. 2007
    ..The results of FDG-PET, however, have not been studied extensively for T-cell and natural killer (NK)-cell neoplasms...
  72. ncbi request reprint Delayed recovery of neutrophil counts after peripheral stem cell transplantation which improved with administration of a minimal dose of G-CSF: a case report
    S Mineishi
    Hematopoietic Stem Cell Transplantation Immunotherapy Unit, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 31:43-5. 2001
    ..As the response occurred on the day following G-CSF administration, a mobilization defect is suspected to be the mechanism of this delayed engraftment...
  73. ncbi request reprint Disseminated tuberculosis following reduced-intensity cord blood transplantation for adult patients with hematological diseases
    T Maeda
    Department of Hematology, Toranomon Hospital, 2 2 2 Toranomon, Minato ku, Tokyo 105 8470, Japan
    Bone Marrow Transplant 35:91-7. 2005
    ..The lack of granuloma in caseous necrosis suggests the impaired T-cell function in early post transplant phase of RI-UCBT. We should consider M. tuberculosis in the differential diagnoses of fever of unknown source after RI-UCBT...
  74. ncbi request reprint Human herpes virus-8 associated with two cases of primary-effusion lymphoma
    N Niitsu
    First Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
    Ann Hematol 79:336-9. 2000
    ..The prognosis of this disease is believed to be poor, therefore more cases should be collected to establish reliable therapy for PEL...
  75. ncbi request reprint Fulminant Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder with hemophagocytosis following autologous peripheral blood stem cell transplantation for relapsed angioimmunoblastic T-cell lymphoma
    Norihiro Awaya
    Department of Medicine, Division of Hematology, Keio University School of Medicine, Japan
    Leuk Res 30:1059-62. 2006
    ..The patient's AILT remained in complete remission. To the best of our knowledge, this is the first case of fulminant EBV-associated T-cell lymphoproliferative disorder (LPD) following autologous HSCT...
  76. ncbi request reprint A novel polymorphism, 70Leu/Phe, disrupts a consensus Leu residue within the leucine-rich repeat sequence of platelet glycoprotein Ibalpha
    Yumiko Matsubara
    Department of Medicine, School of Medicine, Keio University, Tokyo, Japan
    Thromb Haemost 87:867-72. 2002
    ..Ristocetin-induced 125I-vWF binding to L70F, however, did not differ from that to WT...