T Kanda

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Efficacy of lamivudine or entecavir against virological rebound after achieving HBV DNA negativity in chronic hepatitis B patients
    Tomoo Miyauchi
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba 260 8677, Japan
    Int J Med Sci 10:647-52. 2013
  2. pmc Ultra-deep sequencing analysis of the hepatitis A virus 5'-untranslated region among cases of the same outbreak from a single source
    Shuang Wu
    1 Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Int J Med Sci 11:60-4. 2014
  3. pmc Hepatic STAT1-nuclear translocation and interleukin 28B polymorphisms predict treatment outcomes in hepatitis C virus genotype 1-infected patients
    Tatsuo Miyamura
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    PLoS ONE 6:e28617. 2011
  4. pmc Adherence to medication is a more important contributor to viral breakthrough in chronic hepatitis B patients treated with entecavir than in those with Lamivudine
    Hidehiro Kamezaki
    Departments of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int J Med Sci 10:567-74. 2013
  5. pmc Acute liver failure in an antimitochondrial antibody-positive 63-year-old man
    Toru Wakamatsu
    Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, Chiba, Japan
    Case Rep Gastroenterol 6:394-9. 2012
  6. pmc Efficacy of lamivudine or entecavir on acute exacerbation of chronic hepatitis B
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int J Med Sci 9:27-32. 2012
  7. pmc Alanine aminotransferase elevation during peginterferon alpha-2a or alpha-2b plus ribavirin treatment
    Masato Nakamura
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int J Med Sci 10:1015-21. 2013
  8. pmc Acute liver failure associated with propylthiouracil in a pregnant 26-year-old woman
    Tatsuo Miyamura
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, Japan
    Case Rep Gastroenterol 7:240-4. 2013
  9. ncbi request reprint Different effects of three interferons L on Toll-like receptor-related gene expression in HepG2 cells
    Tatsuo Kanda
    Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan Electronic address
    Cytokine 64:577-83. 2013
  10. pmc Peginterferon Alfa-2a plus ribavirin in Japanese patients infected with hepatitis C virus genotype 2 who failed previous interferon therapy
    Tatsuo Kanda
    Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Int J Med Sci 10:43-9. 2013

Collaborators

Detail Information

Publications96

  1. pmc Efficacy of lamivudine or entecavir against virological rebound after achieving HBV DNA negativity in chronic hepatitis B patients
    Tomoo Miyauchi
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba 260 8677, Japan
    Int J Med Sci 10:647-52. 2013
    ..In contrast, LAM could not inhibit HBV replication even if HBV negativity was achieved in the early phase. Attention should be paid to these features in clinical practice...
  2. pmc Ultra-deep sequencing analysis of the hepatitis A virus 5'-untranslated region among cases of the same outbreak from a single source
    Shuang Wu
    1 Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Int J Med Sci 11:60-4. 2014
    ..It might be more interesting to perform ultra-deep sequencing of full length HAV genome in order to reveal possible unknown genomic determinants associated with disease severity. Further studies will be needed. ..
  3. pmc Hepatic STAT1-nuclear translocation and interleukin 28B polymorphisms predict treatment outcomes in hepatitis C virus genotype 1-infected patients
    Tatsuo Miyamura
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    PLoS ONE 6:e28617. 2011
    ....
  4. pmc Adherence to medication is a more important contributor to viral breakthrough in chronic hepatitis B patients treated with entecavir than in those with Lamivudine
    Hidehiro Kamezaki
    Departments of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int J Med Sci 10:567-74. 2013
    ..0% of ETV- and 94.1% of LAM-treated patients with viral breakthrough (P=0.047). Viral breakthrough associated with poor adherence could be a more important issue in the treatment with especially stronger NAs, such as ETV...
  5. pmc Acute liver failure in an antimitochondrial antibody-positive 63-year-old man
    Toru Wakamatsu
    Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, Chiba, Japan
    Case Rep Gastroenterol 6:394-9. 2012
    ....
  6. pmc Efficacy of lamivudine or entecavir on acute exacerbation of chronic hepatitis B
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int J Med Sci 9:27-32. 2012
    ..We compared the effects of lamivudine (LAM) with those of entecavir (ETV) treatments in acute exacerbation of chronic hepatitis B with 500 IU/L or higher alanine aminotransferase (ALT) levels...
  7. pmc Alanine aminotransferase elevation during peginterferon alpha-2a or alpha-2b plus ribavirin treatment
    Masato Nakamura
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int J Med Sci 10:1015-21. 2013
    ..In conclusion, clinicians should pay attention to possible ALT elevation during the treatment of chronic hepatitis C patients. ..
  8. pmc Acute liver failure associated with propylthiouracil in a pregnant 26-year-old woman
    Tatsuo Miyamura
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, Japan
    Case Rep Gastroenterol 7:240-4. 2013
    ..She was successfully treated without liver transplantation. Attention should be paid to the possible occurrence of propylthiouracil-induced hepatotoxicity even during the first trimester of pregnancy. ..
  9. ncbi request reprint Different effects of three interferons L on Toll-like receptor-related gene expression in HepG2 cells
    Tatsuo Kanda
    Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan Electronic address
    Cytokine 64:577-83. 2013
    ..IFNL is a powerful modulator of innate immune response and it is supposed that the 3 IFNLs may play different roles in the antiviral activity against HBV and HCV. ..
  10. pmc Peginterferon Alfa-2a plus ribavirin in Japanese patients infected with hepatitis C virus genotype 2 who failed previous interferon therapy
    Tatsuo Kanda
    Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Int J Med Sci 10:43-9. 2013
    ..Attention should be paid to certain patients with unique features. Selection of patients according to their previous treatment could lead to optimal therapy in HCV genotype 2 treatment-experienced patients...
  11. doi request reprint Interleukin-29 suppresses hepatitis A and C viral internal ribosomal entry site-mediated translation
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, Chiba, Japan
    Viral Immunol 25:379-86. 2012
    ..Combining IL-29 with IFN-α or amantadine resulted in stronger inhibition of HAV IRES activity. Our findings demonstrated a novel antiviral effect of IFNs-λ against HAV and HCV through the suppression of IRES-mediated translation...
  12. ncbi request reprint Knockdown of receptor-interacting serine/threonine protein kinase-2 (RIPK2) affects EMT-associated gene expression in human hepatoma cells
    Shuang Wu
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Chuo Ku, Chiba, Japan
    Anticancer Res 32:3775-83. 2012
    ..We investigated the effects of RIPK2 knockdown in human hepatoma cells on epithelial-to-mesenchymal transition (EMT)-associated gene expression...
  13. ncbi request reprint Pegylated interferon-alfa plus ribavirin therapies for chronic hepatitis C
    T Kanda
    Department of Gastroenterology, Chiba University Hospital, Japan
    JNMA J Nepal Med Assoc 51:41-8. 2011
    ..Our Japanese experiences should provide new information for the treatment of chronic hepatitis C...
  14. pmc Inhibitory effects on HAV IRES-mediated translation and replication by a combination of amantadine and interferon-alpha
    Lingli Yang
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Virol J 7:212. 2010
    ..In conclusion, amantadine, in combination of IFN-alpha, might have a beneficial effect in some patients with acute hepatitis A...
  15. ncbi request reprint State of hepatitis C viral replication enhances activation of NF-kB- and AP-1-signaling induced by hepatitis B virus X
    Tatsuo Kanda
    Safety and Health Organization, Chiba University, 1 33 Yayoicho, Inage Ku, Chiba 263 8522, Japan
    Cancer Lett 234:143-8. 2006
    ..HBx protein might play an important role in HCV-related hepatocarcinogenesis...
  16. doi request reprint Occurrence of hepatocellular carcinoma was not a rare event during and immediately after antiviral treatment in Japanese HCV-positive patients
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    Oncology 80:366-72. 2011
    ..Clinicians should regularly check for the possible development of HCC even in chronic hepatitis C patients under treatment...
  17. doi request reprint Response to peginterferon-alfa 2b and ribavirin in Japanese patients with chronic hepatitis C genotype 2
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Dig Dis Sci 56:3335-42. 2011
    ..The current standard treatment for patients infected with hepatitis C virus (HCV) of genotype 2 is the combination of peginterferon (PEG-IFN) plus ribavirin (RBV) for 24 weeks...
  18. pmc Analysis of 5' nontranslated region of hepatitis A viral RNA genotype I from South Korea: comparison with disease severities
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    PLoS ONE 5:e15139. 2010
    ..In conclusion, HAV 5'NTR subgenotype IA from Korea had relatively high homology to Japanese sequences previously reported from Japan, and this region would be considered one of the antiviral targets. Further studies will be needed...
  19. doi request reprint Quantification of hepatitis C virus in patients treated with peginterferon-alfa 2a plus ribavirin treatment by COBAS TaqMan HCV test
    T Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Viral Hepat 18:e292-7. 2011
    ..7%) at week 8, and 41/43 (95.3%) at week 12]. The utilization of both undetectable RNA and <1.7 log IU/mL HCV RNA by COBAS TaqMan HCV test is useful and could predict SVR and non-SVR patients with greater accuracy...
  20. ncbi request reprint Occurrence of autoimmune hepatitis during the course of primary biliary cirrhosis: report of two cases
    Tatsuo Kanda
    First Department of Medicine, Chiba University School of Medicine, Chiba, Japan
    Dig Dis Sci 51:45-6. 2006
  21. ncbi request reprint Acute-onset autoimmune hepatitis resembling acute hepatitis: a case report and review of reported cases
    Tatsuo Kanda
    First Department of Internal Medicine, Chiba University School of Medicine, Chiba, Japan
    Hepatogastroenterology 52:1233-5. 2005
    ..This is the third such case report in the literature...
  22. ncbi request reprint 5-aza-2'-deoxycytidine sensitizes hepatoma and pancreatic cancer cell lines
    Tatsuo Kanda
    The Department of Medicine and Clinical Oncology, Graduate School of Medicine Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    Oncol Rep 14:975-9. 2005
    ....
  23. ncbi request reprint Hepatitis A virus (HAV) proteinase 3C inhibits HAV IRES-dependent translation and cleaves the polypyrimidine tract-binding protein
    T Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    J Viral Hepat 17:618-23. 2010
    ..The combined results suggest that 3C-mediated cleavage of PTB might be involved in down-regulation of viral translation to give way to subsequent viral genome replication...
  24. ncbi request reprint Enhanced sensitivity of human hepatoma cells to 5-fluorouracil by small interfering RNA targeting Bcl-2
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan
    DNA Cell Biol 24:805-9. 2005
    ..5 +/- 0.86)%, respectively. The Bcl-2 siRNA prior to 5-FU treatment group showed the strongest effect of inducing apoptosis. In conclusion, the combination Bcl-2 siRNA and 5-FU might represent a new therapeutic option for HCC...
  25. ncbi request reprint Inhibition of subgenomic hepatitis C virus RNA replication in HeLa cells
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Hepatogastroenterology 54:32-5. 2007
    ..The aim of this study was to evaluate the effect of interferon or ribavirin treatment on subgenomic HCV RNA replication in 'non-hepatic' HeLa cells...
  26. ncbi request reprint Amantadine inhibits hepatitis A virus internal ribosomal entry site-mediated translation in human hepatoma cells
    Tatsuo Kanda
    Safety and Health Organization, Chiba University, 1 33 Yayoicho, Inage Ku, Chiba 263 8522, Japan
    Biochem Biophys Res Commun 331:621-9. 2005
    ..Immunoblot analysis revealed that amantadine had no effect on PKR and on IFN-regulatory factor-1 (IRF-1) expression. These findings demonstrated a novel antiviral effect of amantadine against HAV with or without HCV infection...
  27. ncbi request reprint Prevalence of obesity in patients with acute hepatitis; is severe obesity a risk factor for fulminant hepatitis in Japan?
    Tatsuo Kanda
    First Department of Internal Medicine, Chiba University School of Medicine, Chiba University, Japan
    Hepatogastroenterology 52:180-2. 2005
    ..The prevalence of obesity in acute convalescent hepatitis and fulminant hepatitis has not been reported. The aim of this study was to investigate whether obesity affected the disease severity in Japanese patients with acute hepatitis...
  28. ncbi request reprint Hepatitis B virus X protein (HBx)-induced apoptosis in HuH-7 cells: influence of HBV genotype and basal core promoter mutations
    T Kanda
    Dept of Medicine and Clinical Oncology, Graduate School of Medicine, Health Sciences Center, Chiba University, Chiba, Japan
    Scand J Gastroenterol 39:478-85. 2004
    ..The functional significance of naturally occurring variants of human HBx remains largely unknown. The purpose of the study was to investigate whether HBV genotypes or double mutations affect HBx-induced apoptosis...
  29. pmc Pegylated interferon-alfa-2a monotherapy in patients infected with HCV genotype 2 and importance of rapid virological response
    Reiko Etoh
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    BMC Res Notes 4:316. 2011
    ..abstract:..
  30. ncbi request reprint Prolonged hepatitis caused by cytomegalovirus and non-alcoholic steatohepatitis in 16-year-old obese boy
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, 260 0856 Chiba, Japan
    Eur J Pediatr 164:212-5. 2005
    ..We report on an 16-year-old boy with prolonged hepatitis associated with NASH after cytomegalovirus hepatitis. Increased transaminase levels recovered in parallel to his weight reduction...
  31. ncbi request reprint Acute hepatitis C virus infection, 1986-2001: a rare cause of fulminant hepatitis in Chiba, Japan
    Tatsuo Kanda
    First Department of Medicine, Chiba University School of Medicine, Japan
    Hepatogastroenterology 51:556-8. 2004
    ..Hepatitis C virus (HCV) is the most common cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. It is controversial whether HCV causes fulminant hepatitis...
  32. ncbi request reprint Interference of hepatitis A virus replication by small interfering RNAs
    Tatsuo Kanda
    Health Sciences Center, Chiba University, Yayoicho, Inage Ku, Chiba, Japan
    Biochem Biophys Res Commun 318:341-5. 2004
    ..These results suggest that RNA interference might ultimately be useful in treatment of severe HAV infection with or without chronic liver diseases...
  33. ncbi request reprint Inhibition of subgenomic hepatitis C virus RNA in Huh-7 cells: ribavirin induces mutagenesis in HCV RNA
    T Kanda
    Health Sciences Center, Chiba University, Inage Ku, Chiba, Japan
    J Viral Hepat 11:479-87. 2004
    ..Our results further suggested that the combination of alpha-IFN 2b and ribavirin might induce mutations, and inhibit HCV RNA synthesis in hepatocytes to a greater extent than ribavirin monotherapy...
  34. doi request reprint Longitudinal changes of the laboratory data of chronic hepatitis C patients with sustained virological response on long-term follow-up
    D Maruoka
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba City, Japan
    J Viral Hepat 19:e97-104. 2012
    ..3 ± 140.0 and 100.5 ± 123.4 in fibrosis 0-1 and 2-4, respectively. HCV RNA negativity persisted in all patients with SVR, and laboratory data including APRI longitudinally improved during the long-term follow-up period...
  35. ncbi request reprint The role of TT virus infection in acute viral hepatitis
    T Kanda
    First Department of Medicine, Chiba University School of Medicine, Chiba, Japan
    Hepatology 29:1905-8. 1999
    ..Although TTV was detected frequently in non-A-E acute hepatitis, no etiologic role for TTV could be established...
  36. pmc Distribution of hepatitis B viral genotypes and mutations in the core promoter and precore regions in acute forms of liver disease in patients from Chiba, Japan
    T Imamura
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan
    Gut 52:1630-7. 2003
    ....
  37. ncbi request reprint Hepatitis A virus VP3 may activate serum response element associated transcription
    T Kanda
    Dept of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Scand J Gastroenterol 38:307-13. 2003
    ..To clarify the effects of HAV infection on intracellular signalling, we examined the influence of 9 FLAG-tagged HAV proteins (VP2, VP3, VP1-2A, 2B, 2C, 3A, 3BC, 3C and 3D) on signal transduction pathways...
  38. ncbi request reprint Sequence-motif analysis of 5'-untranslated region of GB virus-C in Japanese patients
    T Kanda
    First Department of Medicine, Chiba University School of Medicine, Japan
    J Gastroenterol Hepatol 15:1048-53. 2000
    ..The internal ribosomal entry site (IRES) at the 5'-untranslated region of GBV-C and an initiating codon at nucleotides (nt) 552-554 have been proposed. We investigated the validity of this proposal...
  39. ncbi request reprint Suppression of hepatitis A virus genome translation and replication by siRNAs targeting the internal ribosomal entry site
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Biochem Biophys Res Commun 330:1217-23. 2005
    ..Our study suggests that some HAV IRES domains might be used as a universal and effective target for specific inhibition of HAV infection...
  40. ncbi request reprint Roles of TT virus infection in various types of chronic hepatitis
    T Ikeuchi
    First Department of Internal Medicine, Chiba University School of Medicine, Chiba, Japan
    Intervirology 44:219-23. 2001
    ..Clinical characteristics of the chronic illness were similar for patients with or without TTV in all hepatitis groups. The etiologic role of TTV in chronic hepatitis is not confirmed from the statistical and clinical standpoint...
  41. ncbi request reprint Analysis of the complete hepatitis B virus genome in patients with genotype C chronic hepatitis and hepatocellular carcinoma
    Kai Yu Zhang
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba City, Chiba 260 8670, Japan
    Cancer Sci 98:1921-9. 2007
    ..8, and 1.4 times, respectively, in HepG2 cells. Substitutions and deletion of nucleotides of the HBV genome, especially the pre-S2 deletion and G1317A and T1341C/A/G mutations may be useful markers for predicting the development of HCC...
  42. doi request reprint Clinical importance of serum hepatitis B surface antigen levels in chronic hepatitis B
    S Togo
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Viral Hepat 18:e508-15. 2011
    ..05). The serial measurement of quantitative HBsAg level has the possibility of predicting the occurrence of HBeAg seroconversion...
  43. ncbi request reprint Sequential gene expression changes in cancer cell lines after treatment with the demethylation agent 5-Aza-2'-deoxycytidine
    Makoto Arai
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer 106:2514-25. 2006
    ....
  44. doi request reprint Association between mutations in the core region of hepatitis C virus genotype 1 and hepatocellular carcinoma development
    Shingo Nakamoto
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba City, Chiba 260 8670, Japan
    J Hepatol 52:72-8. 2010
    ..To determine whether amino acid mutations in the core region of hepatitis C virus (HCV) genotype 1 are associated with response to interferon (IFN) therapy and development of hepatocellular carcinoma (HCC)...
  45. ncbi request reprint Lower incidence of hepatic failure than hepatocellular carcinoma in Japanese patients with chronic hepatitis C
    Fumio Imazeki
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Liver Int 25:772-8. 2005
    ..We investigated the status in Japan in a retrospective cohort study...
  46. ncbi request reprint Prolonged acute hepatitis A mimicking autoimmune hepatitis
    Rintaro Mikata
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    World J Gastroenterol 11:3791-3. 2005
    ..We report a case with a prolonged course of hepatitis A, with alanine aminotransferase (ALT) higher than 500 IU/L for more than 2 mo...
  47. ncbi request reprint Body mass index in Japanese patients with autoimmune liver disease: overweight patients with primary biliary cirrhosis tend to be asymptomatic
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan
    Hepatogastroenterology 54:1758-60. 2007
    ..The aim of this study was to investigate the effects of being overweight on autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) patients...
  48. pmc Importance of adequate immunosuppressive therapy for the recovery of patients with "life-threatening" severe exacerbation of chronic hepatitis B
    Keiichi Fujiwara
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    World J Gastroenterol 11:1109-14. 2005
    ..In this study we evaluated the efficacy of early introduction of high-dose corticosteroid therapy in patients with life-threatening severe exacerbation of chronic hepatitis B...
  49. ncbi request reprint Hepatic graft-versus-host disease resembling acute hepatitis: additional treatment with ursodeoxycholic acid
    Tetsuhiro Chiba
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba City, Chiba 260 8670, Japan
    Liver 22:514-7. 2002
    ..His liver function test completely returned to normal on day 260. We believe that it is worthwhile to administer UDCA as an additional treatment for not only common hepatic GVHD but also atypical cases presenting as acute hepatitis...
  50. ncbi request reprint Fas polymorphisms influence susceptibility to autoimmune hepatitis
    Akira Hiraide
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba City, Japan
    Am J Gastroenterol 100:1322-9. 2005
    ..Polymorphisms of the gene encoding Fas have been linked to a variety of autoimmune diseases. We hypothesized that Fas gene polymorphisms might be genetic markers for AIH and PBC...
  51. ncbi request reprint Severe hypercholesterolemia associated with primary biliary cirrhosis in a 44-year-old Japanese woman
    Tatsuo Kanda
    First Department of Medicine, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba City, Chiba 260 8670, Japan
    World J Gastroenterol 10:2607-8. 2004
    ..She showed a severely high total cholesterol level. This article focuses on atypical presentations of PBC and the need to test the total cholesterol level of PBC patients...
  52. ncbi request reprint Risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection
    Kenichi Ito
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Scand J Gastroenterol 45:243-9. 2010
    ..To determine the risk factors for the occurrence of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) infection...
  53. doi request reprint Quantification of hepatitis C amino acid substitutions 70 and 91 in the core coding region by real-time amplification refractory mutation system reverse transcription-polymerase chain reaction
    Shingo Nakamoto
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, Japan
    Scand J Gastroenterol 44:872-7. 2009
    ..The purpose of this study was to establish real-time amplification refractory mutation system (ARMS) reverse transcription (RT)-polymerase chain reaction (PCR) assays for easy detection of these HCV mutations...
  54. ncbi request reprint Analysis of genes upregulated by the demethylating agent 5-aza-2'-deoxycytidine in gastric cancer cell lines
    Rintaro Mikata
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Cancer 119:1616-22. 2006
    ..In particular, the suppression of BCL2L10, which could induce apoptosis and inhibit proliferation of cancer cells, might be one of the underlying mechanisms for gastric carcinogenesis...
  55. ncbi request reprint High sustained virologic response rate after interferon monotherapy in Japanese hepatitis C patients with a low HCV RNA titer and/or HCV genotype 2. A prospective study
    Osamu Yokosuka
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Intervirology 47:328-34. 2004
    ..To clarify whether interferon monotherapy is really effective in patients with the appropriate viral parameters, we prospectively examined these parameters and treated the patients with interferon monotherapy...
  56. ncbi request reprint Augmentation of hepatic glucose uptake by a positive glucose gradient between hepatoportal and central nervous systems
    M Matsuhisa
    First Department of Medicine, Osaka University School of Medicine, Suita, Japan
    Diabetes 46:1101-5. 1997
    ....
  57. doi request reprint Pfetin as a prognostic biomarker in gastrointestinal stromal tumor: novel monoclonal antibody and external validation study in multiple clinical facilities
    Kazutaka Kikuta
    Proteome Bioinformatics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 40:60-72. 2010
    ..To develop prognostic modalities for GIST patients, we developed a mouse monoclonal antibody against pfetin, the prognostic value of which has been previously reported...
  58. ncbi request reprint Prevalence of diabetes mellitus and insulin resistance in patients with chronic hepatitis C: comparison with hepatitis B virus-infected and hepatitis C virus-cleared patients
    Fumio Imazeki
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Liver Int 28:355-62. 2008
    ....
  59. ncbi request reprint Analysis of the complete hepatitis B virus genome in patients with genotype C chronic hepatitis in relation to HBeAg and anti-HBe
    Kaiyu Zhang
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Med Virol 79:683-93. 2007
    ..This whole genome analysis of HBV chronic carriers suggested that the nucleotide substitutions and deletions in HBV were closely associated with the pathogenesis of chronic HBV infection...
  60. ncbi request reprint Serum osteopontin levels in patients with acute liver dysfunction
    Makoto Arai
    Department of Medicine and Clinical Oncology, Graduate School of Medicine Chiba University, Japan
    Scand J Gastroenterol 41:102-10. 2006
    ..We demonstrated that the expression of osteopontin (OPN), a multifunctional cytokine, was up-regulated in mouse oval cell (a stem-cell progenitor) induction models...
  61. ncbi request reprint Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease
    Hajime Sumi
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan
    Hepatology 37:19-26. 2003
    ....
  62. ncbi request reprint Evaluation of clinical usefulness of second-generation HCV core antigen assay: comparison with COBAS AMPLICOR HCV MONITOR assay version 2.0
    Osamu Yokosuka
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Liver Int 25:1136-41. 2005
    ..Hepatitis C virus (HCV) is an important etiologic agent for chronic liver diseases...
  63. ncbi request reprint Pleomorphic phenotypes of gastrointestinal stromal tumors at metastatic sites with or without imatinib treatment
    Kazuha Sakamoto
    Department of Diagnostic Pathology, Graduate School of Medicine, Gunma University, Gunma, Japan
    Cancer Sci 101:1270-8. 2010
    ..A KIT-independent mechanism, such as activation of other RTKs, might participate in the proliferation of late-stage GISTs and might be a cause of secondary imatinib resistance...
  64. ncbi request reprint Fulminant hepatic failure associated with triazolam
    Tatsuo Kanda
    First Department of Medicine, Chiba University School of Medicine, Inohana, Japan
    Dig Dis Sci 47:1111-4. 2002
  65. ncbi request reprint [A case of steatohepatitis associated with tamoxifen]
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University
    Nihon Shokakibyo Gakkai Zasshi 99:1119-21. 2002
  66. ncbi request reprint Effect of lamivudine in HBeAg-positive chronic hepatitis B: discordant effect on HBeAg and HBV DNA according to pretreatment ALT level
    Tomoko Kurihara
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuou Ward, Chiba 260 8670, Japan
    World J Gastroenterol 11:3346-50. 2005
    ..To clarify differences in antiviral effect of the drug in patients with different ALT levels, we examined the changes in HBV markers in patients with high or low ALT levels with or without lamivudine treatment...
  67. ncbi request reprint Bezafibrate treatment: a new medical approach for PBC patients?
    Tatsuo Kanda
    First Department of Medicine, Chiba University School of Medicine, Japan
    J Gastroenterol 38:573-8. 2003
    ..A new medical approach to primary biliary cirrhosis (PBC) has been desired. We investigated the feasibility of using combination ursodeoxycholic acid (UDCA)-bezafibrate therapy in patients with PBC nonresponsive to UDCA monotherapy...
  68. ncbi request reprint Hepatitis C infection with history of tuberculosis in Japan: no association with progression of liver fibrosis
    Tatsuo Kanda
    J Gastroenterol Hepatol 19:717-9. 2004
  69. doi request reprint Secondary mutations in the kinase domain of the KIT gene are predominant in imatinib-resistant gastrointestinal stromal tumor
    Toshirou Nishida
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Osaka, Japan
    Cancer Sci 99:799-804. 2008
    ..Resistant lesions showed monoclonal development of tumor cells. Taken together, additional cis-positioned mutations in the kinase domains are a major cause of secondary resistance to imatinib in Japanese GIST patients...
  70. pmc Generation of infectious hepatitis C virus in immortalized human hepatocytes
    Tatsuo Kanda
    Department of Pathology, Saint Louis University, 3635 Vista Avenue, St Louis, Missouri 63110, USA
    J Virol 80:4633-9. 2006
    ..A similar level of virus growth was observed upon transfection of RNA from HCV genotype 2a (JFH1) into IHH. Taken together, our results suggest that IHH support HCV genome replication and virus assembly...
  71. pmc Silencing of hepatitis A virus infection by small interfering RNAs
    Yuri Kusov
    Institute of Medical Molecular Biology, University of Lubeck, Ratzeburger Allee 160, 23562 Lübeck, Germany
    J Virol 80:5599-610. 2006
    ..This siRNA holds promise as a therapeutic tool for severe courses of HAV infection. In addition, the results provide new insight into the structural bases for sequence-specific RNAi...
  72. ncbi request reprint Hepatitis A protein VP1-2A reduced cell viability in Huh-7 cells with hepatitis C virus subgenomic RNA replication
    Tatsuo Kanda
    J Gastroenterol Hepatol 21:625-6. 2006
  73. ncbi request reprint Corticosteroids and lamivudine combined to treat acute severe flare-up in a chronic hepatitis B and C patient
    Tatsuo Kanda
    J Gastroenterol Hepatol 19:238-9. 2004
  74. pmc Small interfering RNA targeted to hepatitis C virus 5' nontranslated region exerts potent antiviral effect
    Tatsuo Kanda
    Departments of Pathology, Saint Louis University, St Louis, Missouri 63110, USA
    J Virol 81:669-76. 2007
    ..Therefore, we have identified a conserved sequence targeted to the HCV genome that can inhibit replication of different genotypes, suggesting the potential of siRNA as an additional therapeutic modality against HCV infection...
  75. pmc Hepatitis C virus genotype 1a growth and induction of autophagy
    Malika Ait-Goughoulte
    Division of Infectious Diseases and Immunology, Center for Vaccine Development, Edward A Doisy Research Center, 1100 S Grand Blvd, 8th Floor, St Louis, MO 63104, USA
    J Virol 82:2241-9. 2008
    ..Taken together, our results suggested that HCV genotype 1a (clone H77) can be serially passaged in IHH and that HCV infection induces an autophagic response in hepatocytes...
  76. ncbi request reprint [Viral factors and host factors in pathogenesis of fulminant hepatitis, type B]
    Tatsuo Kanda
    Health Sciences Center, Chiba University
    Nihon Rinsho 62:259-63. 2004
  77. ncbi request reprint NY-ESO-1 expression and its serum immunoreactivity in esophageal cancer
    Argun Akcakanat
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 951 8510 Niigata, Japan
    Cancer Chemother Pharmacol 54:95-100. 2004
    ..The objectives of this study were to analyze the antibody response to NY-ESO-1 antigen in patients with esophageal cancer and to determine the potential of NY-ESO-1 for use in tumor-specific immunotherapy...
  78. ncbi request reprint N-nitroso-fenfluramine hepatotoxicity resembling chronic hepatitis
    Tatsuo Kanda
    J Gastroenterol Hepatol 18:999-1000. 2003
  79. ncbi request reprint Clinical and diagnostic significance of preoperative computed tomography findings of ascites in patients with advanced gastric cancer
    Kazuhito Yajima
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Am J Surg 192:185-90. 2006
    ..The relationship between ascites, as detected by preoperative computed tomography (CT), and peritoneal metastasis of gastric cancer requires clarification because of its likely significance for clinical outcome...
  80. ncbi request reprint Fulminant hepatic failure associated with benzbromarone treatment: a case report
    Makoto Arai
    J Gastroenterol Hepatol 17:625-6. 2002
  81. ncbi request reprint [Two cases of postoperative recurrence of gastric GIST treated by imatinib]
    Hirotoshi Kikuchi
    Dept of Surgery, Hamamatsu University School of Medicine
    Gan To Kagaku Ryoho 31:1569-73. 2004
    ..IM is the treatment of choice for unresectable recurrence of GIST. However, some problems remained. Both basic and clinical research is necessary to increase the therapeutic efficacy of IM...
  82. ncbi request reprint [Indication of hepatic resection for metastatic liver tumors from gastric cancer]
    Manabu Ohashi
    Division of Digestive and General Surgery, Niigata Graduate School of Medical and Dental Sciences
    Gan To Kagaku Ryoho 31:1891-3. 2004
    ....
  83. pmc Sulfated homologues of heparin inhibit hepatitis C virus entry into mammalian cells
    Arnab Basu
    Division of Infectious Diseases and Immunology, Department of Internal Medicine, Saint Louis University, 3635 Vista Ave, FDT 8N, St Louis, MO 63110, USA
    J Virol 81:3933-41. 2007
    ..Taken together, our results suggest that the HCV envelope glycoproteins rely upon O-sulfated esters of a heparin homologue to facilitate entry into mammalian cells...
  84. pmc Multiple carcinoids in the duodenum, pancreas and stomach accompanied with type A gastritis: a case report
    Takeo Bamba
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    World J Gastroenterol 13:2247-9. 2007
    ..Although no definitive evidence has been obtained, some sort of genetic anomaly may have been involved in this case, and hypergastrinemia due to duodenal gastrinoma may induce multiple gastric carcinoids...
  85. ncbi request reprint Surgical interventions for focal progression of advanced gastrointestinal stromal tumors during imatinib therapy
    Junichi Hasegawa
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Int J Clin Oncol 12:212-7. 2007
    ..The aim of this study was to retrospectively analyze the safety and prognostic effects of surgical interventions for focal progression during imatinib treatment...
  86. pmc Hepatitis C virus infection induces the beta interferon signaling pathway in immortalized human hepatocytes
    Tatsuo Kanda
    Department of Pathology, Saint Louis University, St Louis, MO 63104, USA
    J Virol 81:12375-81. 2007
    ..Together, our results suggested that HCV infection in IHH induces the IFN signaling pathway, which corroborates observations from natural HCV infection in humans...
  87. ncbi request reprint [Safety and efficacy of hypotonic CDDP intraperitoneal administration for gastric cancer with peritoneal dissemination]
    Takeo Bamba
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences
    Gan To Kagaku Ryoho 32:1695-7. 2005
    ..Although intraperitoneal CDDP administration is safe to be carried out intraoperatively, the effect on survival is not better than new anticancer drugs, such as TS-1 and paclitaxel...
  88. ncbi request reprint Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors
    Hirotoshi Kikuchi
    Second Department of Surgery, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu 431 3192, Japan
    Cancer Sci 98:1734-9. 2007
    ..LOH of the c-kit gene in metastatic liver seems to be a common event, and LOH of the c-kit gene in resected liver GIST may be a helpful factor in the prediction of the post-recurrent prognosis of patients with liver metastasis...
  89. ncbi request reprint Comparison of the levels of accuracy of an artificial neural network model and a logistic regression model for the diagnosis of acute appendicitis
    Shinya Sakai
    Division of Information Science and Biostatistics, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori 1 754, Niigata 951 8520, Japan
    J Med Syst 31:357-64. 2007
    ..The most accurate diagnosis was obtained by the artificial neural network model using normalized variables...
  90. pmc Hepatitis C virus core protein augments androgen receptor-mediated signaling
    Tatsuo Kanda
    Department of Pathology, St Louis University, 1100 S Grand Blvd, DRC 207, St Louis, MO 63104, USA
    J Virol 82:11066-72. 2008
    ..Together, our results suggest that HCV core protein acts as a positive regulator in AR signaling, providing further insight into oncogenic potential in the development of HCC in HCV-infected individuals...
  91. ncbi request reprint [Safety and efficacy of chemotherapy using TS-1 followed by paclitaxel for advanced or recurrent gastric cancer with peritoneal dissemination]
    Manabu Ohashi
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences
    Gan To Kagaku Ryoho 32:1640-2. 2005
    ..Chemotherapy using TS-1 followed by paclitaxel is considered to be safe and effective for gastric cancer with peritoneal dissemination...
  92. ncbi request reprint Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine
    Mayuko Nakahara
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113 8657
    J Biol Chem 280:42283-9. 2005
    ....
  93. ncbi request reprint Efficacy and toxicity of fluorouracil, doxorubicin, and cisplatin/nedaplatin treatment as neoadjuvant chemotherapy for advanced esophageal carcinoma
    Shin Ichi Kosugi
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    Scand J Gastroenterol 40:886-92. 2005
    ..The aim of this study was to evaluate the efficacy and toxicity of neoadjuvant chemotherapy using fluorouracil, doxorubicin, and cisplatin or nedaplatin (FAP/N) in these patients...
  94. ncbi request reprint Establishment and characterization of monoclonal and polyclonal antibodies against human intestinal fatty acid-binding protein (I-FABP) using synthetic regional peptides and recombinant I-FABP
    Satoshi Kajiura
    Dainippon Sumitomo Pharma Co, Ltd, Osaka, Japan
    J Immunoassay Immunochem 29:19-41. 2008
    ..It is anticipated that, in the near future, such a method for measuring I-FABP will be developed as a useful tool for diagnosing intestinal ischemia by using some of these antibodies...
  95. ncbi request reprint Adenocarcinoma arising from heterotopic gastric mucosa in the stomach
    Shin Ichi Kosugi
    J Gastroenterol Hepatol 21:483-4. 2006