T Kadowaki

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation
    Hironori Waki
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    PLoS Genet 7:e1002311. 2011
  2. pmc Potential formula for the calculation of starting and incremental insulin glargine doses: ALOHA subanalysis
    Takashi Kadowaki
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 7:e41358. 2012
  3. ncbi request reprint Adiponectin, adiponectin receptors, and epigenetic regulation of adipogenesis
    T Kadowaki
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cold Spring Harb Symp Quant Biol 76:257-65. 2011
  4. ncbi request reprint Glucose metabolism and glutamate analog acutely alkalinize pH of insulin secretory vesicles of pancreatic beta-cells
    Kazuhiro Eto
    Dept of Metabolic Diseases, Graduate School of Medicine, Univ of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Endocrinol Metab 285:E262-71. 2003
  5. ncbi request reprint [PPAR gamma agonist and antagonist]
    T Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Nihon Yakurigaku Zasshi 118:321-6. 2001
  6. ncbi request reprint The role of PPARgamma in high-fat diet-induced obesity and insulin resistance
    Takashi Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku 113 8655, Tokyo, Japan
    J Diabetes Complications 16:41-5. 2002
  7. doi request reprint A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
    Toshimasa Yamauchi
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Nat Genet 42:864-8. 2010
  8. ncbi request reprint The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS
    Takashi Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    FEBS Lett 582:74-80. 2008
  9. pmc Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    Takashi Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 116:1784-92. 2006
  10. ncbi request reprint Adiponectin and adiponectin receptors
    Takashi Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Endocr Rev 26:439-51. 2005

Collaborators

Detail Information

Publications141 found, 100 shown here

  1. pmc Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation
    Hironori Waki
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    PLoS Genet 7:e1002311. 2011
    ..Together, our study demonstrates the utility of FAIRE-seq in providing a global view of cell type-specific regulatory elements in the genome and in identifying transcriptional regulators of adipocyte differentiation...
  2. pmc Potential formula for the calculation of starting and incremental insulin glargine doses: ALOHA subanalysis
    Takashi Kadowaki
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    PLoS ONE 7:e41358. 2012
    ..To derive a useful formula for calculating recommended glargine doses, we analyzed data from the Add-on Lantus® to Oral Hypoglycemic Agents (ALOHA) study, a 24-week observation of Japanese type 2 diabetes patients...
  3. ncbi request reprint Adiponectin, adiponectin receptors, and epigenetic regulation of adipogenesis
    T Kadowaki
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cold Spring Harb Symp Quant Biol 76:257-65. 2011
    ....
  4. ncbi request reprint Glucose metabolism and glutamate analog acutely alkalinize pH of insulin secretory vesicles of pancreatic beta-cells
    Kazuhiro Eto
    Dept of Metabolic Diseases, Graduate School of Medicine, Univ of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Endocrinol Metab 285:E262-71. 2003
    ..Moreover, glutamate derived from glucose may be one of the mediators of this alkalinizing effect of glucose, which may have potential relevance to the alteration of secretory function by glutamate...
  5. ncbi request reprint [PPAR gamma agonist and antagonist]
    T Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Nihon Yakurigaku Zasshi 118:321-6. 2001
    ..Our data suggest that appropriate functional antagonism of PPAR gamma/RXR may be a logical approach to protection against obesity and related diseases such as type 2 diabetes...
  6. ncbi request reprint The role of PPARgamma in high-fat diet-induced obesity and insulin resistance
    Takashi Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku 113 8655, Tokyo, Japan
    J Diabetes Complications 16:41-5. 2002
    ..These results revealed that both in mice and humans, PPARgamma is a thrifty gene mediating Type 2 diabetes...
  7. doi request reprint A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
    Toshimasa Yamauchi
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Nat Genet 42:864-8. 2010
    ..78 × 10⁻¹⁴, whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D...
  8. ncbi request reprint The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS
    Takashi Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    FEBS Lett 582:74-80. 2008
    ..We propose a hypothesis on the physiological role of adiponectin: a starvation gene in the course of evolution by promoting fat storage on facing the loss of adiposity...
  9. pmc Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    Takashi Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 116:1784-92. 2006
    ..This Review describes the pathophysiology of adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome...
  10. ncbi request reprint Adiponectin and adiponectin receptors
    Takashi Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Endocr Rev 26:439-51. 2005
    ..Adiponectin receptor agonists and adiponectin sensitizers should serve as versatile treatment strategies for obesity-linked diseases such as diabetes and metabolic syndrome...
  11. ncbi request reprint Molecular mechanism of insulin resistance and obesity
    Takashi Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Exp Biol Med (Maywood) 228:1111-7. 2003
    ..Further investigation will be needed to clarify how adiponectin exerts its effect and to discover the molecular target of therapies...
  12. ncbi request reprint Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver
    K Tobe
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 276:38337-40. 2001
    ..Interestingly, high dose leptin administration reduced SREBP-1 expression in IRS-2(-/-) mouse liver. Thus, IRS-2 gene disruption results in leptin resistance, causing an SREBP-1 gene induction, obesity, fatty liver, and diabetes...
  13. ncbi request reprint Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia
    N Kubota
    Department of Metabolic Disease, Graduate School of Medicine, University of Tokyo, Japan
    Diabetes 49:1880-9. 2000
    ..These results suggest that IRS-1 and IRS-2 may play different roles in the regulation of beta-cell mass and the function of individual beta-cells...
  14. ncbi request reprint Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice
    Y Tsuji
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Diabetes 50:1455-63. 2001
    ....
  15. ncbi request reprint A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats
    K Murakami
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Diabetes 47:1841-7. 1998
    ..01) in inducing the PPAR-gamma-regulated aP2 gene mRNA expression in the adipose tissues. These results suggest that PPAR-alpha agonism has a protective effect against abnormal lipid metabolism in liver of obese rats...
  16. pmc Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice
    T Yamauchi
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Mol Cell Biol 16:3074-84. 1996
    ....
  17. pmc Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes
    T Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 108:1001-13. 2001
    ..Our data suggested that appropriate functional antagonism of PPARgamma/RXR may be a logical approach to protection against obesity and related diseases such as type 2 diabetes...
  18. ncbi request reprint The role of PPARgamma as a thrifty gene both in mice and humans
    K Hara
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Br J Nutr 84:S235-9. 2000
    ..These results revealed that in both mice and humans, PPARgamma is a thrifty gene mediating type 2 diabetes...
  19. ncbi request reprint The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance
    T Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan
    J Biol Chem 276:41245-54. 2001
    ....
  20. pmc Restored insulin-sensitivity in IRS-1-deficient mice treated by adenovirus-mediated gene therapy
    K Ueki
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 105:1437-45. 2000
    ..These data suggest that PKB in liver plays a pivotal role in systemic glucose homeostasis and that PKB activation might be sufficient for reducing insulin resistance even without full activation of PI3K...
  21. ncbi request reprint Insulin-independent and wortmannin-resistant targeting of IRS-3 to the plasma membrane via its pleckstrin homology domain mediates a different interaction with the insulin receptor from that of IRS-1
    Y Kaburagi
    The Department of Metabolic Disease, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan
    Diabetologia 44:992-1004. 2001
    ....
  22. ncbi request reprint PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
    N Kubota
    Department of Metabolic Diseases, University of Tokyo, Japan
    Mol Cell 4:597-609. 1999
    ..This study reveals a hitherto unpredicted role for PPAR gamma in high-fat diet-induced obesity due to adipocyte hypertrophy and insulin resistance, which requires both alleles of PPAR gamma...
  23. doi request reprint Daily total physical activity level and total cancer risk in men and women: results from a large-scale population-based cohort study in Japan
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Am J Epidemiol 168:391-403. 2008
    ..By site, decreased risks were observed for cancers of the colon, liver, and pancreas in men and for cancer of the stomach in women. Increased daily physical activity may be beneficial in preventing cancer in a relatively lean population...
  24. ncbi request reprint Vascular endothelial growth factor induces activation and subcellular translocation of focal adhesion kinase (p125FAK) in cultured rat cardiac myocytes
    N Takahashi
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo
    Circ Res 84:1194-202. 1999
    ..These results strongly suggest that p125(FAK) is one of the most important components in VEGF-induced signaling in cardiac myocytes, playing a critical role in adhesive interaction between cardiac myocytes and ECM...
  25. ncbi request reprint Impact of lifestyle on overall cancer risk among Japanese: the Japan Public Health Center-based Prospective Study (JPHC Study)
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    J Epidemiol 20:90-6. 2010
    ..Although people with a history of diabetes may be at increased risk of cancer, extreme body mass index and metabolic factors in the aggregate had little impact on overall cancer risk in the Japanese population...
  26. doi request reprint Body weight at age 20 years, subsequent weight change and breast cancer risk defined by estrogen and progesterone receptor status--the Japan public health center-based prospective study
    Reiko Suzuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 129:1214-24. 2011
    ..50-3.34)]. Low BMI at age 20 years was substantially associated with an increased risk of breast cancer. In contrast, high recent BMI and subsequent BMI gain from age 20 were associated with increased risk of postmenopausal ER+PR+ tumors...
  27. doi request reprint Female reproductive factors and the risk of gastric cancer in a large-scale population-based cohort study in Japan (JPHC study)
    Christina Persson
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Eur J Cancer Prev 17:345-53. 2008
    ..Although early estrogen exposure may have some protective effect, female reproductive factors may have no substantial influence on gastric cancer development...
  28. doi request reprint Alcohol and risk of lung cancer among Japanese men: data from a large-scale population-based cohort study, the JPHC study
    Taichi Shimazu
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Causes Control 19:1095-102. 2008
    ..Here, we investigated the association between alcohol consumption and lung cancer incidence...
  29. ncbi request reprint [The molecular mechanisms by which PPAR gamma/RXR inhibitors improve insulin resistance]
    T Yamauchi
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo
    Nippon Rinsho 59:2245-54. 2001
    ..We conclude that although by different mechanisms, both PPAR gamma/RXR inhibitors and PPAR gamma agonist improve insulin resistance, which is associated with decreased TG content of muscle/liver and prevention of adipocyte hypertrophy...
  30. doi request reprint Calcium, vitamin D and dairy intake in relation to type 2 diabetes risk in a Japanese cohort
    K Kirii
    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Diabetologia 52:2542-50. 2009
    ..Calcium and vitamin D have been implicated in the development of type 2 diabetes, but epidemiological evidence is limited. We examined prospectively the relation of calcium and vitamin D intake to type 2 diabetes risk in a Japanese cohort...
  31. doi request reprint The impact of the metabolic syndrome and its components on the incidence of ischemic heart disease and stroke: the Japan public health center-based study
    Hiroyuki Noda
    Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Hypertens Res 32:289-98. 2009
    ....
  32. ncbi request reprint The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    T Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Nat Med 7:941-6. 2001
    ..These data also indicate that the replenishment of adiponectin might provide a novel treatment modality for insulin resistance and type 2 diabetes...
  33. doi request reprint Body mass index and subsequent risk of kidney cancer: a prospective cohort study in Japan
    Norie Sawada
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Ann Epidemiol 20:466-72. 2010
    ..Herein, we investigate the association between body mass index (BMI) and kidney cancer risk in Japanese persons, a relatively lean population...
  34. ncbi request reprint Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase
    T Yamauchi
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan
    J Biol Chem 273:15719-26. 1998
    ..Taken together, the role of IRS-1, -2, and -3 in GH and PRL signalings appears to be phosphorylated by JAK2, thereby providing docking sites for p85 PI3-kinase and activating PI3-kinase and its downstream biological effects...
  35. ncbi request reprint Constitutive tyrosine phosphorylation of ErbB-2 via Jak2 by autocrine secretion of prolactin in human breast cancer
    T Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113, Japan
    J Biol Chem 275:33937-44. 2000
    ..The identification of this novel cross-talk between ErbB-2 and the autocrine growth stimulatory loop for PRL may provide new targets for therapeutic and preventive intervention of human breast cancer...
  36. doi request reprint Coffee, green tea, and caffeine consumption and subsequent risk of bladder cancer in relation to smoking status: a prospective study in Japan
    Norie Kurahashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Cancer Sci 100:294-91. 2009
    ..15–3.66), respectively. In conclusion, cigarette smoking was confirmed as a risk factor for bladder cancer. Coffee and caffeine may be associated with an increased bladder cancer risk in never or former smokers among Japanese men...
  37. ncbi request reprint A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes
    K Hara
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Japan
    Diabetologia 45:740-3. 2002
    ..Thus, PGC-1 can be viewed as a functional and positional candidate for the susceptibility gene for Type II (non-insulin-dependent) diabetes mellitus...
  38. doi request reprint Leisure-time physical activity and breast cancer risk defined by estrogen and progesterone receptor status--the Japan Public Health Center-based Prospective Study
    Reiko Suzuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Tokyo, 104 0045, Japan
    Prev Med 52:227-33. 2011
    ..The study aims to investigate the association between leisure-time physical activity and breast cancer risk in consideration of tumor estrogen-receptor/progesterone-receptor status...
  39. ncbi request reprint Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population
    M Horikoshi
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Diabetologia 50:2461-6. 2007
    ..The aim of this study was to determine the association between single nucleotide polymorphisms (SNPs) in these genes and type 2 diabetes in participants from the Japanese population...
  40. pmc Two aberrant splicings caused by mutations in the insulin receptor gene in cultured lymphocytes from a patient with Rabson-Mendenhall's syndrome
    Y Takahashi
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Clin Invest 101:588-94. 1998
    ..We speculate that this mutant receptor may be involved in the relatively long survival of the patient by rescuing otherwise more severe phenotypes resulting from the complete lack of functional insulin receptors...
  41. ncbi request reprint Insulin effect during embryogenesis determines fetal growth: a possible molecular link between birth weight and susceptibility to type 2 diabetes
    Y Terauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Diabetes 49:82-6. 2000
    ..Taken together, these results suggest that a genetically programmed insulin effect during embryogenesis determines fetal growth and provides a possible molecular link between birth weight and susceptibility to type 2 diabetes...
  42. ncbi request reprint Hexamminecobalt(III) chloride inhibits glucose-induced insulin secretion at the exocytotic process
    Y Tsubamoto
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    J Biol Chem 276:2979-85. 2001
    ....
  43. pmc Association of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic function
    H Ueno
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo 113, Japan
    Mol Biol Cell 11:735-46. 2000
    ..Our results indicate that IRS proteins transmit signals from the insulin receptor to Bcl-2, thus regulating cell survival probably through regulating phosphorylation of Bcl-2...
  44. doi request reprint Serum aminotransferase level and the risk of hepatocellular carcinoma: a population-based cohort study in Japan
    Seiji Ishiguro
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Eur J Cancer Prev 18:26-32. 2009
    ..This finding indicates that ALT level is a good independent determinant of the need for intervention. Clinical application of these findings may help decrease HCC-associated mortality in hepatitis virus-endemic regions...
  45. doi request reprint Isoflavone consumption and subsequent risk of hepatocellular carcinoma in a population-based prospective cohort of Japanese men and women
    Norie Kurahashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 124:1644-9. 2009
    ..Women with hepatitis virus infection may be advised to abstain from isoflavone consumption. Further studies are warranted to confirm these findings...
  46. doi request reprint Type A behaviour and risk of coronary heart disease: the JPHC Study
    Ai Ikeda
    Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University Suita shi, Osaka, Japan
    Int J Epidemiol 37:1395-405. 2008
    ..Although numerous studies of type A behaviour and risk of coronary heart disease (CHD) have been reported in the west (with mixed findings), few studies have been carried out in Asian populations...
  47. doi request reprint Taste preferences and body weight change in Japanese adults: the JPHC Study
    Y Matsushita
    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Shinjuku ku, Tokyo, Japan
    Int J Obes (Lond) 33:1191-7. 2009
    ..Limited data are available with regard to longitudinal changes in body weight by food taste preference. Here, we examined the associations between taste preferences and weight change in adults for a large-scale cohort study in Japan...
  48. pmc Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease
    Y Terauchi
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo ku, Japan
    J Clin Invest 99:861-6. 1997
    ..In conclusion, the genetic abnormalities, each of which is nondiabetogenic by itself, cause overt diabetes if they coexist. This report provides the first genetic reconstitution of NIDDM as a polygenic disorder in mice...
  49. ncbi request reprint Importance of standardization of hemoglobin A1c in the analysis of factors that predict hemoglobin A1c levels in non-diabetic residents of three distinct areas of Japan
    Y Takahashi
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan
    Diabetes Res Clin Pract 53:91-7. 2001
    ..Thus, standardization of HbA1c reduced the difference between assay systems, and uncovered two common factors to determine HbA1c levels...
  50. doi request reprint Effect of alcohol consumption, cigarette smoking and flushing response on esophageal cancer risk: a population-based cohort study (JPHC study)
    Seiji Ishiguro
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Lett 275:240-6. 2009
    ..10-5.51). Strong effect modification was detected in heavy smokers. Our results suggest that heavy alcohol consumption together with heavy smoking may increase the risk of ESCC particularly in individuals with the flushing response...
  51. doi request reprint Reproductive factors, exogenous female hormone use and colorectal cancer risk: the Japan Public Health Center-based Prospective Study
    Munira Akhter
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Eur J Cancer Prev 17:515-24. 2008
    ..59). In contrast, no statistically significant association was found for rectal cancer. These findings suggest that late age at first birth is associated with a reduced risk of colon cancer in postmenopausal Japanese women...
  52. doi request reprint Coffee consumption and risk of endometrial cancer: a prospective study in Japan
    Taichi Shimazu
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 123:2406-10. 2008
    ..Coffee consumption may be associated with a decreased risk of endometrial cancer...
  53. pmc Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation
    H Miki
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Mol Cell Biol 21:2521-32. 2001
    ..Our results suggest that IRS-1 and IRS-2 play a crucial role in the upregulation of the C/EBPalpha and PPARgamma expression and adipocyte differentiation...
  54. ncbi request reprint A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population
    M Horikoshi
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo, 113 8655, Japan
    Diabetologia 50:747-51. 2007
    ..We studied whether the single nucleotide polymorphisms (SNPs) in TCF7L2 were associated with type 2 diabetes in samples from a Japanese population...
  55. doi request reprint Serum cholesterol levels in relation to the incidence of cancer: the JPHC study cohorts
    Hiroyasu Iso
    Department of Social and Environmental Medicine, Public Health, Graduate School of Medicine, Osaka University, Suita Shi, Osaka, Japan
    Int J Cancer 125:2679-86. 2009
    ..Although the inverse association for liver cancer remained to be examined further, our findings do not support that low serum total cholesterol levels increase risks of total cancer and other major sites...
  56. ncbi request reprint Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    T Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Nat Med 8:1288-95. 2002
    ..Our data may provide a novel paradigm that an adipocyte-derived antidiabetic hormone, Ad, activates AMPK, thereby directly regulating glucose metabolism and insulin sensitivity in vitro and in vivo...
  57. doi request reprint Impact of viral load of hepatitis C on the incidence of hepatocellular carcinoma: A population-based cohort study (JPHC Study)
    Seiji Ishiguro
    National Cancer Center, Tokyo, Japan
    Cancer Lett 300:173-9. 2011
    ..The risk was 3.86-fold higher (CI; 1.73-8.62) for genotype 1 than genotype 2. Our findings suggest that HCV viremia strongly influences the occurrence of hepatocellular carcinoma without titer-dependence...
  58. ncbi request reprint Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase
    Y Terauchi
    Department of Internal Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Japan
    Nat Genet 21:230-5. 1999
    ..Our work provides the first direct evidence that PI3K and its regulatory subunit have a role in glucose homeostasis in vivo...
  59. doi request reprint Dairy product, saturated fatty acid, and calcium intake and prostate cancer in a prospective cohort of Japanese men
    Norie Kurahashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 17:930-7. 2008
    ..62 (1.15-2.29) and 1.53 (1.07-2.20), respectively. In conclusion, our results suggest that the intake of dairy products may be associated with an increased risk of prostate cancer...
  60. doi request reprint Fruit and vegetable consumption and squamous cell carcinoma of the esophagus in Japan: the JPHC study
    Taiki Yamaji
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Int J Cancer 123:1935-40. 2008
    ..Finally, cruciferous vegetables deserve further investigation as foods possibly effective in the prevention of esophageal SCC...
  61. doi request reprint High dietary intake of magnesium may decrease risk of colorectal cancer in Japanese men
    Enbo Ma
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    J Nutr 140:779-85. 2010
    ..There were no significant associations between magnesium intake and cancer risk in women. Higher dietary intake of magnesium may decrease the risk of CRC in Japanese men...
  62. doi request reprint Alcohol consumption-associated breast cancer incidence and potential effect modifiers: the Japan Public Health Center-based Prospective Study
    Reiko Suzuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Chuo Ku, Tokyo, Japan
    Int J Cancer 127:685-95. 2010
    ..15). Excessive alcohol intake was associated with an increase in the risk of breast cancer in this population. There was no statistical evidence for effect modification...
  63. doi request reprint Plasma testosterone and sex hormone-binding globulin concentrations and the risk of prostate cancer among Japanese men: a nested case-control study
    Norie Sawada
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Sci 101:2652-7. 2010
    ..In conclusion, in this nested case-control study, concentrations of circulating total testosterone, free testosterone or SHBG were not strongly associated with a risk for total prostate cancer...
  64. doi request reprint Validity of self-reported cancer among a Japanese population: recent results from a population-based prospective study in Japan (JPHC Study)
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Cancer Epidemiol 35:250-3. 2011
    ..Self-reported diagnoses of cancer do not provide sufficient accuracy for the detection and classification of incident cancers. Our findings may be extrapolated to other Japanese populations...
  65. ncbi request reprint Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone
    T Yamauchi
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Nature 390:91-6. 1997
    ..This may represent a novel cross-talk pathway between the cytokine receptor superfamily and growth factor receptor...
  66. ncbi request reprint Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity
    Atsushi Tsuchida
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 279:30817-22. 2004
    ....
  67. pmc Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus
    Naoto Kubota
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 114:917-27. 2004
    ..We conclude that, in beta cells and the hypothalamus, Irs2 is crucially involved in the regulation of beta cell mass and leptin sensitivity...
  68. ncbi request reprint Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis
    Toshimasa Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Japan
    J Biol Chem 278:2461-8. 2003
    ..In conclusion, replenishment of globular adiponectin may provide a novel treatment modality for both type 2 diabetes and atherosclerosis...
  69. ncbi request reprint Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways
    Naoto Kubota
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655
    J Biol Chem 281:8748-55. 2006
    ..Thus, pioglitazone-induced amelioration of insulin resistance and diabetes may occur adiponectin dependently in the liver and adiponectin independently in skeletal muscle...
  70. ncbi request reprint Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice
    Ryo Suzuki
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 279:25039-49. 2004
    ..We therefore concluded that a combination of increased EGP due to insulin signaling defects in the liver and reduced Rd due to obesity accounts for the systemic insulin resistance in Irs2(-/-) mice...
  71. ncbi request reprint Genetic manipulations of fatty acid metabolism in beta-cells are associated with dysregulated insulin secretion
    Kazuhiro Eto
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Diabetes 51:S414-20. 2002
    ..These results revealed some aspects about the mechanisms by which alterations of fatty acid metabolism affect beta-cell functions...
  72. ncbi request reprint A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance
    Junji Kamon
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 323:242-8. 2004
    ..These observations suggest that "insulin-stimulated Akt activity in adipocytes" may play an important role in the regulation of adiponectin secretion...
  73. ncbi request reprint Increased serum leptin protects from adiposity despite the increased glucose uptake in white adipose tissue in mice lacking p85alpha phosphoinositide 3-kinase
    Yasuo Terauchi
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Diabetes 53:2261-70. 2004
    ..Our findings suggest that primary increase in serum leptin on the normal diet play a role in the protection from adiposity in Pik3r1(-/-) mice...
  74. ncbi request reprint [The mechanisms by which PPARgamma and adiponectin regulate glucose and lipid metabolism]
    Junji Kamon
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Japan
    Nihon Yakurigaku Zasshi 122:294-300. 2003
    ....
  75. doi request reprint Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis
    Takeharu Asano
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Gastroenterol Hepatol 24:1669-76. 2009
    ..We used adiponectin KO mice fed a high fat (HF) diet, and investigated the effect of adiponectin on the progression of steatohepatitis and carcinogenesis in vivo...
  76. ncbi request reprint [Genetic susceptibility of type 2 diabetes]
    Kazuo Hara
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Seikagaku 75:1345-60. 2003
  77. ncbi request reprint A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population
    Momoko Horikoshi
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Diabetes 55:919-23. 2006
    ..002; and joint replication control subjects [n = 552], P = 0.037). We speculate that the PRKAA2 gene influences insulin resistance and susceptibility to type 2 diabetes in the Japanese population...
  78. ncbi request reprint Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways
    Yusuke Shinoda
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Cell Biochem 99:196-208. 2006
    ....
  79. ncbi request reprint Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance
    Nozomu Kamei
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 281:26602-14. 2006
    ..We concluded that both paracrine and endocrine effects of MCP-1 may contribute to the development of insulin resistance in aP2-MCP-1 mice...
  80. ncbi request reprint Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet
    Junji Matsui
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Diabetes 53:2844-54. 2004
    ..Our results demonstrate that PPAR-gamma protects islets from lipotoxicity by regulating TG partitioning among tissues and that a PPAR-gamma agonist can restore impaired insulin secretion under conditions of islet fat accumulation...
  81. ncbi request reprint Adiponectin receptor signaling: a new layer to the current model
    Takashi Kadowaki
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cell Metab 13:123-4. 2011
    ..Recent work in Nature Medicine (Holland et al., 2011) suggests that adiponectin stimulates ceramidase activity through AdipoR1 and AdipoR2, an activity potentially involved in promoting cell survival...
  82. ncbi request reprint Adiponectin and adiponectin receptors in obesity-linked insulin resistance
    Takashi Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, Universiay of Tokyo, Tokyo, Japan
    Novartis Found Symp 286:164-76; discussion 176-82, 200-3. 2007
    ..Up-regulation of adiponectin or adiponectin receptors may represent potential versatile therapeutic targets to combat obesity-linked diseases characterized by insulin resistance...
  83. ncbi request reprint Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population
    Kazuo Hara
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Diabetes 51:536-40. 2002
    ..Based on these findings together with the observation that adiponectin improves insulin sensitivity in animal models, we conclude that the adiponectin gene may be a susceptibility gene for type 2 diabetes...
  84. ncbi request reprint [PPAR family (PPAR alpha, PPAR delta, PPAR gamma)]
    Junji Kamon
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo
    Nihon Rinsho 60:593-600. 2002
  85. ncbi request reprint [Molecular mechanism of insulin resistance]
    Kazuyuki Tobe
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo
    Nihon Rinsho 63:114-30. 2005
  86. ncbi request reprint ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase signaling
    Kohtaro Minami
    Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Am J Physiol Endocrinol Metab 285:E1289-96. 2003
    ..2 gene. Disruption of Kir6.2-containing Katp channels clearly protects against IRS-1-associated insulin resistance by increasing glucose uptake in skeletal muscles by a mechanism separate from the IRS-1/PI3K pathway...
  87. ncbi request reprint Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice
    Yasuo Terauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Japan
    J Biol Chem 278:14284-90. 2003
    ....
  88. ncbi request reprint Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
    Toshimasa Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Nature 423:762-9. 2003
    ....
  89. ncbi request reprint [Current status of analysis of type 2 diabetes genes]
    Takashi Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo
    Nihon Rinsho 60:477-86. 2002
  90. ncbi request reprint [Mechanisms by which PPAR gamma modulators regulate insulin sensitivity]
    Toshimasa Yamauchi
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo
    Nihon Rinsho 60:578-87. 2002
  91. ncbi request reprint [Knockout mouse models for type 2 diabetes. Mice with impaired insulin secretion]
    Yasuo Terauchi
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo
    Nihon Rinsho 60:58-63. 2002
  92. ncbi request reprint [Perspective for personalized medicine for diabetes]
    Takashi Kadowaki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo
    Nihon Rinsho 60:729-37. 2002
  93. ncbi request reprint [Genomics of type 2 diabetes]
    Kazuo Hara
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo
    Nihon Rinsho 60:283-9. 2002
  94. ncbi request reprint Expression of DGAT2 in white adipose tissue is regulated by central leptin action
    Ryo Suzuki
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 280:3331-7. 2005
    ..We propose the hypothesis that leptin regulates adipocyte size by altering expression patterns of DGAT via central nervous system to determine the levels of triglyceride synthesis...
  95. doi request reprint Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways
    Taku Watanabe
    Department of Diabetes and Metabolic Diseases, University of Tokyo, Tokyo, Japan
    J Biol Chem 284:1803-12. 2009
    ..Thus, it was concluded that rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways...
  96. pmc PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
    Toru Akune
    Department of Orthopaedic Surgery, University of Tokyo, Japan
    J Clin Invest 113:846-55. 2004
    ..This study demonstrates a PPARgamma-dependent regulation of bone metabolism in vivo, in that PPARgamma insufficiency increases bone mass by stimulating osteoblastogenesis from bone marrow progenitors...
  97. ncbi request reprint Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c
    Tokuyuki Yamashita
    Department of Metabolic Diseases, University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
    Endocrinology 145:3566-77. 2004
    ..These results suggest that UCP-2 down-regulation and AMPK activation could be candidate targets for releasing beta-cells from lipotoxicity...
  98. ncbi request reprint [Role of NADH shuttle system in glucose-stimulated insulin secretion]
    Kazuhiro Eto
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo
    Nihon Rinsho 60:190-207. 2002
  99. ncbi request reprint [The role of PPARgamma in the onset of type 2 diabetes]
    Kazuo Hara
    Department of Clinical Bioinformatics, Graduate School of Medicine, University of Tokyo, Japan
    Nihon Yakurigaku Zasshi 122:317-24. 2003
    ..Indeed, pharmacological inhibitors of PPARgamma/RXR ameliorates high-fat diet-induced insulin resistance in animal models of type 2 diabetes...
  100. pmc Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts
    Toru Akune
    Department of Orthopaedic Surgery, University of Tokyo, Tokyo 113 8655, Japan
    J Cell Biol 159:147-56. 2002
    ....
  101. ncbi request reprint [Glucokinase]
    Kazuhiro Eto
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo
    Nihon Rinsho 60:523-34. 2002