Hiroto Izumi

Summary

Affiliation: University of Occupational and Environmental Health
Country: Japan

Publications

  1. doi request reprint Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells
    Hiroto Izumi
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan
    Cancer Sci 102:1007-13. 2011
  2. ncbi request reprint Enhanced expression of the human vacuolar H+-ATPase c subunit gene (ATP6L) in response to anticancer agents
    Takayuki Torigoe
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Biol Chem 277:36534-43. 2002
  3. ncbi request reprint P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA
    Yoichiro Yoshida
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu Fukuoka 807 8555, Japan
    Cancer Res 63:3729-34. 2003
  4. ncbi request reprint p73gamma transactivates the p21 promoter through preferential interaction with the p300/CBP-associated factor in human prostate cancer cells
    Yasutomo Momii
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health Japan, Fukuoka 807 8555, Japan
    Oncol Rep 18:411-6. 2007
  5. ncbi request reprint Cisplatin resistance and transcription factors
    Takayuki Torigoe
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, Fukuoka 807 8555, Japan
    Curr Med Chem Anticancer Agents 5:15-27. 2005
  6. doi request reprint Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations
    Chizuko Yamamoto
    Department of Pharmaceutical Oncology and Laboratory of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 70:8715-25. 2010
  7. pmc N-myc downstream regulated gene 1 (NDRG1) promotes metastasis of human scirrhous gastric cancer cells through epithelial mesenchymal transition
    Hiroki Ureshino
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
    PLoS ONE 7:e41312. 2012
  8. doi request reprint Human mitochondrial transcription factor A functions in both nuclei and mitochondria and regulates cancer cell growth
    Bin Han
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan Department of Urology, School of Medicine, University of Occupational and
    Biochem Biophys Res Commun 408:45-51. 2011
  9. ncbi request reprint Thioredoxin2 enhances the damaged DNA binding activity of mtTFA through direct interaction
    Akihiko Kidani
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Int J Oncol 35:1435-40. 2009
  10. doi request reprint Twist promotes tumor cell growth through YB-1 expression
    Masaki Shiota
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer Res 68:98-105. 2008

Detail Information

Publications58

  1. doi request reprint Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells
    Hiroto Izumi
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan
    Cancer Sci 102:1007-13. 2011
    ..This is the first report suggesting that lactate transporters are involved in human cancer cell invasiveness. As such, these proteins may be promising targets for the prevention of cancer invasion and metastasis...
  2. ncbi request reprint Enhanced expression of the human vacuolar H+-ATPase c subunit gene (ATP6L) in response to anticancer agents
    Takayuki Torigoe
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Biol Chem 277:36534-43. 2002
    ..Our data suggest that the induction of V-ATPase expression is an anti-apoptotic defense, and V-ATPase inhibitors in combination with low-dose anticancer agents may provide a new therapeutic approach...
  3. ncbi request reprint P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA
    Yoichiro Yoshida
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu Fukuoka 807 8555, Japan
    Cancer Res 63:3729-34. 2003
    ..Binding of mtTFA to cisplatin-modified DNA was significantly enhanced by p53, whereas binding to oxidized DNA was inhibited. Our findings suggest that the interaction of p53 with mtTFA may play an important role in apoptosis...
  4. ncbi request reprint p73gamma transactivates the p21 promoter through preferential interaction with the p300/CBP-associated factor in human prostate cancer cells
    Yasutomo Momii
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health Japan, Fukuoka 807 8555, Japan
    Oncol Rep 18:411-6. 2007
    ..Our results revealed that p21 promoter activity was affected by differential interactions of p73 variants with PCAF and its acetylation...
  5. ncbi request reprint Cisplatin resistance and transcription factors
    Takayuki Torigoe
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, Fukuoka 807 8555, Japan
    Curr Med Chem Anticancer Agents 5:15-27. 2005
    ..In this review, we summarize the mechanisms of cisplatin resistance and focus on transcription factors involved in the genomic response to cisplatin...
  6. doi request reprint Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations
    Chizuko Yamamoto
    Department of Pharmaceutical Oncology and Laboratory of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 70:8715-25. 2010
    ..Our findings reinforce the therapeutic importance of PTEN expression in the treatment of NSCLC with EGFR-targeted drugs...
  7. pmc N-myc downstream regulated gene 1 (NDRG1) promotes metastasis of human scirrhous gastric cancer cells through epithelial mesenchymal transition
    Hiroki Ureshino
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
    PLoS ONE 7:e41312. 2012
    ..This is the first study to demonstrate that NDRG1 plays its pivotal role in the malignant progression of gastric cancer through epithelial mesenchymal transition...
  8. doi request reprint Human mitochondrial transcription factor A functions in both nuclei and mitochondria and regulates cancer cell growth
    Bin Han
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan Department of Urology, School of Medicine, University of Occupational and
    Biochem Biophys Res Commun 408:45-51. 2011
    ..Knockdown of mtTFA expression induced p21-dependent G1 cell cycle arrest. These results imply that mtTFA functions in both nuclei and mitochondria to promote cell growth...
  9. ncbi request reprint Thioredoxin2 enhances the damaged DNA binding activity of mtTFA through direct interaction
    Akihiko Kidani
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Int J Oncol 35:1435-40. 2009
    ..By contrast, binding to oxidized DNA was significantly enhanced when double mutations were introduced. These results suggest that TRX2 not only functions as an antioxidant, but also supports mtTFA functions...
  10. doi request reprint Twist promotes tumor cell growth through YB-1 expression
    Masaki Shiota
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer Res 68:98-105. 2008
    ..Both YB-1 and Twist expression could induce tumor progression, promoting cell growth and driving oncogenesis in various cancers. Thus, both YB-1 and Twist may represent promising molecular targets for cancer therapy...
  11. doi request reprint Y-box binding protein-1 is a novel molecular target for tumor vessels
    Mayu Takahashi
    Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer Sci 101:1367-73. 2010
    ..Taken together, YB-1 plays an important role in the growth of not only tumor cells but also tumor-associated endothelial cells, suggesting that YB-1 is a promising target for cancer therapy...
  12. doi request reprint Transcriptional regulation of activating transcription factor 4 under oxidative stress in retinal pigment epithelial ARPE-19/HPV-16 cells
    Naoya Miyamoto
    Department of Molecular Biology, University of Occupational and Environmental Health, Japan, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 52:1226-34. 2011
    ..Transcriptional regulation of the ATF4 gene under oxidative stress was investigated in human papillomavirus 16 (HPV-16)-transformed retinal pigment epithelial ARPE-19/HPV-16 cells...
  13. ncbi request reprint DNA topoisomerase II poison TAS-103 transactivates GC-box-dependent transcription via acetylation of Sp1
    Takayuki Torigoe
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Fukuka, Japan
    J Biol Chem 280:1179-85. 2005
    ..Taken together, these findings demonstrate novel genomic responses to anticancer agents that modulate Sp1 acetylation and Sp1-dependent transcription in an apoptotic pathway...
  14. ncbi request reprint Human mitochondrial transcription factor A binds preferentially to oxidatively damaged DNA
    Yoichiro Yoshida
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Fukuoka, Japan
    Biochem Biophys Res Commun 295:945-51. 2002
    ..The affinity for oxidatively damaged DNA of mtTFA is higher for A/8-oxo-dG and C/8-oxo-dG than for G/8-oxo-dG and T/8-oxo-dG. Our findings suggest that mtTFA plays an important role in the recognition of oxidative DNA damage...
  15. ncbi request reprint Transcription factors and drug resistance
    Kimitoshi Kohno
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Fukuoka 807 8555, Japan
    Eur J Cancer 41:2577-86. 2005
    ..Here, we briefly describe the development of solid tumours and the appearance of drug-resistant cells. We also review what is known of the transcription factors that are involved in resistance to drugs, particularly cisplatin...
  16. pmc p300/CBP-associated factor (P/CAF) interacts with nuclear respiratory factor-1 to regulate the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosaminyltransferase-3 gene
    Hiroto Izumi
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Fukuoka 807 8555, Japan
    Biochem J 373:713-22. 2003
    ..Additionally, induced expression of P/CAF may be a component of the adenocarcinoma differentiation process...
  17. doi request reprint Ets regulates peroxiredoxin1 and 5 expressions through their interaction with the high-mobility group protein B1
    Masaki Shiota
    Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
    Cancer Sci 99:1950-9. 2008
    ..Silencing of Ets1, Ets2, Prdx1, and Prdx5 expression sensitized cells to oxidative stress. These data indicate that transcription of Prdx genes mediated by Ets/HMG proteins might protect cells from oxidative stress...
  18. doi request reprint Involvement of riboflavin kinase expression in cellular sensitivity against cisplatin
    Gen Hirano
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807 8555, Japan
    Int J Oncol 38:893-902. 2011
    ..The present study suggests that RFK expression is involved not only in cellular protection from oxidative stress but also in malignant progression of prostate cancer...
  19. doi request reprint Programmed cell death protein 4 down-regulates Y-box binding protein-1 expression via a direct interaction with Twist1 to suppress cancer cell growth
    Masaki Shiota
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    Cancer Res 69:3148-56. 2009
    ..In summary, PDCD4 negatively regulates YB-1 expression via its interaction with Twist1 and is involved in cancer cell growth and chemoresistance...
  20. ncbi request reprint ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA
    Hiroshi Ishiguchi
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan
    Int J Cancer 111:900-9. 2004
    ..ZNF 143 also binds preferentially to cisplatin-modified DNA. These results suggest that ZNF 143 participates in cellular responses to DNA damage...
  21. ncbi request reprint Cellular pH regulators: potentially promising molecular targets for cancer chemotherapy
    Hiroto Izumi
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Fukuoka 807 8555, Japan
    Cancer Treat Rev 29:541-9. 2003
    ..Here, we describe the structure and function of pH regulators expressed in tumour tissue. Understanding pH regulation in tumour cells may provide new ways of inducing tumour-specific apoptosis, thus aiding cancer chemotherapy...
  22. pmc Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression
    Hidetaka Uramoto
    Department of Molecular Biology, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Biochem J 371:301-10. 2003
    ..These results provide novel information on the functional interplay between CTF2 and p53/p73 as important determinants of their function in cell proliferation, apoptosis, DNA repair and cisplatin resistance...
  23. pmc N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells
    Yuichi Murakami
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    J Biol Chem 288:25025-37. 2013
    ..Together, activation of JNK/AP-1 thus seems to promote tumor angiogenesis in relationship to NDRG1-induced inflammatory stimuli by gastric cancer cells. ..
  24. doi request reprint Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status
    Takamitsu Onitsuka
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Thorac Oncol 5:591-6. 2010
    ..The purpose of this study was to clarify the role of the epidermal growth factor receptor (EGFR), K-ras, MET, and hepatocyte growth factor (HGF) status in lung adenocarcinoma...
  25. ncbi request reprint DNA topoisomerase inhibitor, etoposide, enhances GC-box-dependent promoter activity via Sp1 phosphorylation
    Ichiro Niina
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Iseigaoka, Fukuoka, Japan
    Cancer Sci 98:858-63. 2007
    ..Taken together, these findings demonstrate a novel genomic response to anticancer agents that induce Sp1 phosphorylation, and might contribute to tumor progression and drug resistance...
  26. ncbi request reprint Structural and functional characterization of two human V-ATPase subunit gene promoters
    Hiroto Izumi
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, 807 8555, Kitakyushu, Japan
    Biochim Biophys Acta 1628:97-104. 2003
    ....
  27. ncbi request reprint Binding of RNA to p53 regulates its oligomerization and DNA-binding activity
    Yoichiro Yoshida
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, Fukuoka 807 8555, Japan
    Oncogene 23:4371-9. 2004
    ..Furthermore, the oligomerization of p53 is significantly enhanced by disrupting the interaction between p53 and RNA. These findings suggest that binding of RNA to p53 is involved in the mechanism of p53 latency...
  28. ncbi request reprint A new mechanism for primary resistance to gefitinib in lung adenocarcinoma: the role of a novel G796A mutation in exon 20 of EGFR
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Anticancer Res 27:2297-303. 2007
    ..This study suggests that screening tumour samples for a range of EGFR mutations may improve our ability to identify the patients most likely to benefit from EFGR TKIs...
  29. ncbi request reprint Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance
    Naoya Miyamoto
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Biol Chem 283:18218-26. 2008
    ..Our data show that HAT gene expression is required for cisplatin resistance and suggest that Clock and Tip60 regulate not only transcription, but also DNA repair, through periodic histone acetylation...
  30. pmc Low pH enhances Sp1 DNA binding activity and interaction with TBP
    Takayuki Torigoe
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Nucleic Acids Res 31:4523-30. 2003
    ..These findings indicate that pH changes significantly modulate the activity of Sp1 and thus contribute to the cellular response under hypoxic or acidic conditions...
  31. doi request reprint Enhanced expression of nuclear factor I/B in oxaliplatin-resistant human cancer cell lines
    Eiji Kashiwagi
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer Sci 102:382-6. 2011
    ..Forced expression of NFIB induced resistance to oxaliplatin, but not to cisplatin. Taken together, these results suggest that NFIB is a novel and specific biomarker for oxaliplatin resistance in human cancers...
  32. doi request reprint Role of ZNF143 in tumor growth through transcriptional regulation of DNA replication and cell-cycle-associated genes
    Hiroto Izumi
    Department of Molecular Biology Otorhinolaryngology Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer Sci 101:2538-45. 2010
    ..Our data suggest that ZNF143 might be a master regulator of the cell cycle. Our findings also indicate that ZNF143 is a member of the growing list of non-oncogenes that are promising cancer drug targets...
  33. doi request reprint Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway
    Naoya Miyamoto
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 52:1055-63. 2011
    ..The purpose of this study was to investigate whether quercetin can activate transcription factors and induce the expression of the PRDX family...
  34. ncbi request reprint Activating transcription factor 4 increases the cisplatin resistance of human cancer cell lines
    Mizuho Tanabe
    Departments of Molecular Biology and Surgery II, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Fukuoka, Japan
    Cancer Res 63:8592-5. 2003
    ..Both were less sensitive to cisplatin than the parental cells but equally sensitive to vincristine. Our findings suggest that levels of ATF4 expression could help to predict cisplatin sensitivity...
  35. doi request reprint Clinical significance of mitochondrial transcription factor A expression in patients with colorectal cancer
    Yoshifumi Nakayama
    Department of Surgery 1, School of Medicine, University of Occupational Environmental Health, and Department of Gastroenterological and General Surgery, Wakamatsu Hospital, Kitakyushu, Japan
    Oncol Rep 27:1325-30. 2012
    ..The positive mtTFA expression appears to be a useful marker for tumor progression and poor prognosis in patients with CRC...
  36. doi request reprint Strong YB-1 expression is associated with liver metastasis progression and predicts shorter disease-free survival in advanced gastric cancer
    Ying Wu
    Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu City, Fukuoka, Japan
    J Surg Oncol 105:724-30. 2012
    ..In this study we investigated the relationship between YB-1 expression and the clinicopathologic features and metastasis-associated epithelial-mesenchymal transition (EMT) phenotype in advanced GC patients...
  37. ncbi request reprint Enhanced expression of PCAF endows apoptosis resistance in cisplatin-resistant cells
    Gen Hirano
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, 807 8555, Japan
    Mol Cancer Res 8:864-72. 2010
    ..Moreover, knockdown of PCAF induced G(1) arrest and apoptosis. These results suggest that PCAF is one of pleiotropic factors for drug resistance and seems to be critical for cancer cell growth...
  38. ncbi request reprint The pleiotropic functions of the Y-box-binding protein, YB-1
    Kimitoshi Kohno
    Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
    Bioessays 25:691-8. 2003
    ..In addition, we will discuss the diverse range of potential physiological and pathological functions of YB-1...
  39. ncbi request reprint Expression of GalNAc-T3 and its relationships with clinicopathological factors in 61 extrahepatic bile duct carcinomas analyzed using stepwise sections - special reference to its association with lymph node metastases-
    Takahiro Inoue
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 20:267-76. 2007
    ..Clinically, preoperative evaluation of GalNAc-T3 expression is considered to be useful for decisions regarding operative procedures...
  40. doi request reprint Nipradilol and timolol induce Foxo3a and peroxiredoxin 2 expression and protect trabecular meshwork cells from oxidative stress
    Naoya Miyamoto
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 50:2777-84. 2009
    ..Oxidative stress plays an important role in pathogenesis of glaucoma. The purpose of this study is to investigate the novel effect of antiglaucoma drugs on the expression of antioxidant peroxiredoxins of trabecular meshwork (TM) cells...
  41. pmc Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway
    Yoshihiro Yasuniwa
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    PLoS ONE 5:e15330. 2010
    ..These findings suggest that circadian disruption induces the progression of malignant tumors via a Wnt signaling pathway...
  42. ncbi request reprint Expression and cellular localization of dbpC/Contrin in germ cell tumor cell lines
    Takeshi Yoshida
    Department of Molecular Biology, University of Occupational and Environmental Health School of Medicine, Iseigaoka, Kitakyushu 807 8555, Japan
    Biochim Biophys Acta 1759:80-8. 2006
    ..Our findings also suggest that dbpC/Contrin can be used as a molecular tool for the detection of germ cell tumors...
  43. doi request reprint Peroxiredoxins, thioredoxin, and Y-box-binding protein-1 are involved in the pathogenesis and progression of dialysis-associated renal cell carcinoma
    Fumiyoshi Fushimi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, Japan
    Virchows Arch 463:553-62. 2013
    ..Once cancer has developed, antioxidant activity might have a stimulating effect on the progression of dialysis RCC. ..
  44. doi request reprint N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression
    Fumihito Hosoi
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 69:4983-91. 2009
    ..This study suggests a novel mechanism by which NDRG1/Cap43 modulates tumor angiogenesis/growth and infiltration of macrophages/neutrophils through attenuation of NF-kappaB signaling...
  45. ncbi request reprint The role of nuclear Y-box binding protein 1 as a global marker in drug resistance
    Michihiko Kuwano
    Research Center for Innovative Cancer Therapy of the 21st Century COE Program for Medical Science, Kurume University, Fukuoka, Japan
    Mol Cancer Ther 3:1485-92. 2004
    ....
  46. doi request reprint Intracellular HMGB1 transactivates the human IL1B gene promoter through association with an Ets transcription factor PU.1
    Fumihiko Mouri
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Eur J Haematol 80:10-9. 2008
    ..1-deficient murine EL4 thymoma cells. Thus, our data raise the possibility of a novel mechanism which sustains and amplifies inflammatory reactions through physical interaction of PU.1 with intracellular HMGB1 in macrophages/monocytes...
  47. doi request reprint Overexpression of peroxiredoxin 4 protects against high-dose streptozotocin-induced diabetes by suppressing oxidative stress and cytokines in transgenic mice
    Yan Ding
    Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    Antioxid Redox Signal 13:1477-90. 2010
    ..This study, for the first time, implicates that PRDX4 has a pivotal protective function against diabetes progression in this T1DM model...
  48. doi request reprint Y-box binding protein-1 (YB-1) promotes cell cycle progression through CDC6-dependent pathway in human cancer cells
    Yuji Basaki
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Cancer 46:954-65. 2010
    ..In conclusion, YB-1 plays an important role in cell cycle progression at G1/S of human cancer cells. YB-1 thus could be a potent biomarker for tumour growth and cell cycle in its close association with CDC6...
  49. pmc Tumor-Derived Interleukin-1 Promotes Lymphangiogenesis and Lymph Node Metastasis through M2-Type Macrophages
    Kosuke Watari
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 9:e99568. 2014
    ..Accordingly, the IL-1R/M2-type macrophage axis may be a good therapeutic target for patients with this form of lung cancer. ..
  50. doi request reprint Depletion of apoptosis signal-regulating kinase 1 prevents bile duct ligation-induced necroinflammation and subsequent peribiliary fibrosis
    Hirotsugu Noguchi
    Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Am J Pathol 184:644-61. 2014
    ..A specific ASK1 pathway blocker or inhibitor might offer a therapeutic strategy against human cholestatic diseases. ..
  51. ncbi request reprint Prognostic significance of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-3 (GalNAc-T3) expression in patients with gastric carcinoma
    Koji Onitsuka
    Department of Surgery I, University of Occupational and Environmental Health School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555
    Cancer Sci 94:32-6. 2003
    ..0158, Cox proportional hazards model). Our data suggest that GalNAc-T3 expression may be a useful marker for prognosis and differentiation of gastric carcinomas...
  52. pmc Expression of mitochondrial transcription factor A in endometrial carcinomas: clinicopathologic correlations and prognostic significance
    Naoyuki Toki
    Department of Obstetrics and Gynecology, University of Occupational and Environmental Health School of Medicine, 1 1, Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Virchows Arch 456:387-93. 2010
    ..The positive mtTFA expression is a useful maker for progression of the tumors and the poor prognosis of the patients in endometrioid adenocarcinomas...
  53. ncbi request reprint Vacuolar H(+)-ATPase: functional mechanisms and potential as a target for cancer chemotherapy
    Takayuki Torigoe
    Department of Molecular Biology, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Fukuoka 807 8555, Japan
    Anticancer Drugs 13:237-43. 2002
    ..In this minireview, we describe the structure and function of certain proton pumps overexpressed in many tumors--vacuolar H(+)-ATPases--and consider their potential as targets for cancer chemotherapy...
  54. ncbi request reprint p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression
    Hidetaka Uramoto
    Department of Molecular Biology, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Biol Chem 277:31694-702. 2002
    ..Our data suggest that p73 stimulates the transcription of the YB-1 promoter by enhancing recruitment of the c-Myc-Max complex to the E-box...
  55. ncbi request reprint YB-1 is important for an early stage embryonic development: neural tube formation and cell proliferation
    Takeshi Uchiumi
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Biol Chem 281:40440-9. 2006
    ..These results demonstrate that YB-1 is involved in early mouse development, including neural tube closure and cell proliferation...
  56. doi request reprint Circadian disruption and cancer risk: a new concept of stromal niche (review)
    Hiroto Izumi
    Department of Occupational Pneumology, Institute of Industrial Ecological Science, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
    Int J Oncol 44:364-70. 2014
    ..In this review, we summarize our current knowledge regarding the role of circadian rhythms in cancer risk and the relevance of the stromal niche in cancer cell survival and progression. ..
  57. ncbi request reprint [State and treat on the health effect of nanomaterial]
    Yasuo Morimoto
    Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan
    Nihon Rinsho 72:353-60. 2014
    ..We also introduced acceptable exposure concentration of nanoparticles such as titanium dioxide, fullerene and carbon nanotube in Japan...
  58. ncbi request reprint Expression of UDP-N-acetyl-alpha-D-galactosamine-polypeptide galNAc N-acetylgalactosaminyl transferase-3 in relation to differentiation and prognosis in patients with colorectal carcinoma
    Kazunori Shibao
    Department of Surgery I, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishiku, Kitakyushu 807 8555, Japan
    Cancer 94:1939-46. 2002
    ..The authors investigated whether such expression influenced tumor differentiation or prognosis in patients with colorectal carcinoma...