Hiroshi Iwata

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint Lineage of bone marrow-derived cells in atherosclerosis
    Hiroshi Iwata
    Center for Interdisciplinary Cardiovascular Sciences, Harvard Medical School, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Circ Res 112:1634-47. 2013
  2. doi request reprint Novel immune signals and atherosclerosis
    Hiroshi Iwata
    Brigham and Women s Hospital, Department of Medicine, Cardiovascular Division, Center for Interdisciplinary Cardiovascular Sciences, 3 Blackfan Street, 17th Floor, Boston, MA 02115, USA
    Curr Atheroscler Rep 14:484-90. 2012
  3. ncbi request reprint Recurrence of late-acquired incomplete stent apposition following sirolimus-eluting stent implantation
    Hiroshi Iwata
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Invasive Cardiol 20:E265-8. 2008
  4. doi request reprint Impact of primitive cells in intracoronary thrombi on lesion prognosis: temporal analysis of cellular constituents of thrombotic material obtained from patients with acute coronary syndrome
    Hiroshi Iwata
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Heart 96:748-55. 2010
  5. doi request reprint The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response
    Yasutomi Higashikuni
    Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 32:654-61. 2012
  6. doi request reprint Local delivery of synthetic prostacycline agonist augments collateral growth and improves cardiac function in a swine chronic cardiac ischemia model
    Hiroshi Iwata
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Life Sci 85:255-61. 2009
  7. doi request reprint Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages
    Hiroshi Iwata
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Circulation 122:2048-57. 2010
  8. doi request reprint Diagnostic implication of change in b-type natriuretic peptide (BNP) for prediction of subsequent target lesion revascularization following silorimus-eluting stent deployment
    Eriko Hasumi
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8611, Japan
    Int J Cardiol 168:1429-34. 2013
  9. doi request reprint Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice
    Yasutomi Higashikuni
    Department of Cardiovascular Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Hypertens Res 35:62-9. 2012
  10. ncbi request reprint Synthetic retinoid Am80 reduces scavenger receptor expression and atherosclerosis in mice by inhibiting IL-6
    Norifumi Takeda
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 26:1177-83. 2006

Collaborators

Detail Information

Publications22

  1. doi request reprint Lineage of bone marrow-derived cells in atherosclerosis
    Hiroshi Iwata
    Center for Interdisciplinary Cardiovascular Sciences, Harvard Medical School, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Circ Res 112:1634-47. 2013
    ..Expansion of our understanding of pathological roles of various subsets of bone marrow-derived cells in atherosclerosis may lead to identification of novel cellular and molecular targets for development of therapeutic strategies...
  2. doi request reprint Novel immune signals and atherosclerosis
    Hiroshi Iwata
    Brigham and Women s Hospital, Department of Medicine, Cardiovascular Division, Center for Interdisciplinary Cardiovascular Sciences, 3 Blackfan Street, 17th Floor, Boston, MA 02115, USA
    Curr Atheroscler Rep 14:484-90. 2012
    ..Understanding the molecular mechanisms in conjunction with orchestration of monocyte/macrophage biology should provide a basis for novel treatment strategies to prevent the development and progression of atherosclerosis...
  3. ncbi request reprint Recurrence of late-acquired incomplete stent apposition following sirolimus-eluting stent implantation
    Hiroshi Iwata
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Invasive Cardiol 20:E265-8. 2008
    ....
  4. doi request reprint Impact of primitive cells in intracoronary thrombi on lesion prognosis: temporal analysis of cellular constituents of thrombotic material obtained from patients with acute coronary syndrome
    Hiroshi Iwata
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Heart 96:748-55. 2010
    ..However, little is known about the mechanism by which intracoronary thrombi play pathological roles...
  5. doi request reprint The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response
    Yasutomi Higashikuni
    Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 32:654-61. 2012
    ..This study was performed to elucidate its role in pressure overload-induced cardiac hypertrophy...
  6. doi request reprint Local delivery of synthetic prostacycline agonist augments collateral growth and improves cardiac function in a swine chronic cardiac ischemia model
    Hiroshi Iwata
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Life Sci 85:255-61. 2009
    ..We tested feasibility of clinical use of ONO-1301, a synthetic small molecule that stimulates secretion of growth factors from various cell types, to treat patients with chronic myocardial ischemia...
  7. doi request reprint Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages
    Hiroshi Iwata
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Circulation 122:2048-57. 2010
    ....
  8. doi request reprint Diagnostic implication of change in b-type natriuretic peptide (BNP) for prediction of subsequent target lesion revascularization following silorimus-eluting stent deployment
    Eriko Hasumi
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8611, Japan
    Int J Cardiol 168:1429-34. 2013
    ....
  9. doi request reprint Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice
    Yasutomi Higashikuni
    Department of Cardiovascular Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Hypertens Res 35:62-9. 2012
    ..Further clinical trials will be warranted to sufficiently assess the safety and the efficacy of the use of aliskiren in post-MI patients...
  10. ncbi request reprint Synthetic retinoid Am80 reduces scavenger receptor expression and atherosclerosis in mice by inhibiting IL-6
    Norifumi Takeda
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 26:1177-83. 2006
    ....
  11. ncbi request reprint Diagnostic efficacy of coronary CT angiography as a follow-up modality for procedure-related coronary dissection
    Eriko Hasumi
    Department of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan
    Int Heart J 52:240-2. 2011
    ..Thus, coronary CT angiography might be considered as a possible first-line follow-up modality in patients with procedure-related coronary dissection...
  12. doi request reprint Giant tumorous lesions (correction of legions) surrounding the right coronary artery associated with immunoglobulin-G4-related systemic disease
    Masayasu Ikutomi
    Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan
    Cardiology 120:22-6. 2011
    ..This case emphasizes the importance of considering the diagnosis in any patient with abnormally increased wall thickness or ectatic lesions in the coronary arteries...
  13. doi request reprint Prognostic implication of macrocytosis on adverse outcomes after coronary intervention
    Masahiro Myojo
    Department of Cardiovascular Medicine, The University of Tokyo, Graduate School of Medicine, Tokyo 113 8655, Japan
    Atherosclerosis 221:148-53. 2012
    ..The aim of this study was to perform prognostic risk stratification of patients after PCI based on the presence or absence of macrocytosis...
  14. ncbi request reprint Development and implementation of an advanced coronary angiography and intervention database system
    Takahide Kohro
    Department of Translational Research for Healthcare and Clinical Science, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Int Heart J 53:35-42. 2012
    ....
  15. doi request reprint Immunoglobulin G4-related multiple systemic aneurysms and splenic aneurysm rupture during steroid therapy
    Miyu Tajima
    Department of Cardiovascular Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Hum Pathol 45:175-9. 2014
    ..A minor salivary gland biopsy might facilitate the early diagnosis of IgG4-related disease even if (18)F-fluorodeoxyglucose positron emission tomography provides no inflammatory findings. ..
  16. ncbi request reprint Potential contribution of bone marrow-derived precursors to vascular repair and lesion formation: lessons from animal models of vascular diseases
    Hiroshi Iwata
    Department of Cardiovascular Medicine, University of Tokyo Graduate School Medicine, Tokyo, Japan
    Front Biosci 12:4157-67. 2007
    ..This article summarizes what we learned from genetically-modified animals regarding the origins and the fates of vascular cells that contribute to lesion formation...
  17. doi request reprint Reproducibility and diagnostic accuracy of three-layer speckle tracking echocardiography in a swine chronic ischemia model
    Koichi Kimura
    Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan
    Echocardiography 28:1148-55. 2011
    ..We investigated the reproducibility and feasibility of novel three-layer speckle tracking system and compared the diagnostic accuracy with experienced visual interpretation...
  18. ncbi request reprint Preliminary report of tolvaptan treatment in Japanese patients with heart failure
    Hiroaki Semba
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Int Heart J 53:72-4. 2012
    ..We describe our initial experience with this novel agent. Tolvaptan is potentially useful for treatment of heart failure patients with fluid overload who are refractory to conventional diuretic therapies...
  19. doi request reprint Progressive coronary artery-pulmonary artery fistula after size-mismatch cardiac transplantation
    Takumi J Matsubara
    Department of Cardiovascular Medicine, University of Tokyo Hospital, Tokyo, Japan
    ASAIO J 57:346-7. 2011
    ..It is conceivable that size-mismatch heart transplantation may be associated with the development of fistula...
  20. doi request reprint The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function
    Yasutomi Higashikuni
    Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 30:2128-35. 2010
    ..To clarify the impact of breast cancer resistance protein 1 (BCRP1)/ATP-binding cassette transporter subfamily G member 2 (ABCG2) expression on cardiac repair after myocardial infarction (MI)...
  21. ncbi request reprint A synthetic small molecule, ONO-1301, enhances endogenous growth factor expression and augments angiogenesis in the ischaemic heart
    Kazuto Nakamura
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo, Bunkyo ku, Tokyo, Japan
    Clin Sci (Lond) 112:607-16. 2007
    ..In conclusion, our results indicate that ONO-1301 up-regulated endogenous growth factors and promoted angiogenesis in response to acute ischaemia. Therefore ONO-1301 might have a therapeutic potential in treating ischaemic diseases...
  22. ncbi request reprint Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5
    Katsuhito Fujiu
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Circ Res 97:1132-41. 2005
    ....