Hiroko Iwasaki

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver
    Hiroko Iwasaki
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan
    Blood 116:544-53. 2010
  2. doi request reprint Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells
    Yuka Nakamura
    Department of Cell Differentiation, Keio University, Tokyo, Japan
    Blood 116:1422-32. 2010
  3. doi request reprint Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells
    Kentaro Hosokawa
    Department of Cell Differentiation, Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo, Japan
    Blood 116:554-63. 2010
  4. doi request reprint Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice
    Haruko Shima
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 378:467-72. 2009
  5. doi request reprint Acquisition of G₀ state by CD34-positive cord blood cells after bone marrow transplantation
    Haruko Shima
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Exp Hematol 38:1231-40. 2010
  6. ncbi request reprint Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche
    Hiroki Yoshihara
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University, 35 Shinano machi, Tokyo, 160 8582, Japan
    Cell Stem Cell 1:685-97. 2007
  7. doi request reprint Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells
    Yumiko Gomei
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan
    Exp Hematol 38:82-9. 2010
  8. doi request reprint Niche regulation of hematopoietic stem cells in the endosteum
    Fumio Arai
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan
    Ann N Y Acad Sci 1176:36-46. 2009
  9. doi request reprint Cancer stem cells and their niche
    Hiroko Iwasaki
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Tokyo, Japan
    Cancer Sci 100:1166-72. 2009
  10. ncbi request reprint Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction
    Kentaro Hosokawa
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 363:578-83. 2007

Collaborators

Detail Information

Publications11

  1. doi request reprint Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver
    Hiroko Iwasaki
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan
    Blood 116:544-53. 2010
    ..In conclusion, EPCR(+) HSCs resided in the perisinusoidal niche in mouse FL...
  2. doi request reprint Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells
    Yuka Nakamura
    Department of Cell Differentiation, Keio University, Tokyo, Japan
    Blood 116:1422-32. 2010
    ..Altogether, these data suggest that multiple subsets of osteoblasts and mesenchymal progenitor cells constitute the endosteal niche and regulate HSCs in adult bone marrow...
  3. doi request reprint Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells
    Kentaro Hosokawa
    Department of Cell Differentiation, Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo, Japan
    Blood 116:554-63. 2010
    ..These findings suggest that N-cad-mediated cell adhesion is functionally required for the establishment of hematopoiesis in the BM niche after BM transplantation...
  4. doi request reprint Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice
    Haruko Shima
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 378:467-72. 2009
    ..Taken together, these results demonstrate the significance of hypoxia in the maintenance of quiescent human cord blood HSCs...
  5. doi request reprint Acquisition of G₀ state by CD34-positive cord blood cells after bone marrow transplantation
    Haruko Shima
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Exp Hematol 38:1231-40. 2010
    ..The aim of this study was to understand this process in human hematopoietic stem cells after bone marrow transplantation...
  6. ncbi request reprint Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche
    Hiroki Yoshihara
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University, 35 Shinano machi, Tokyo, 160 8582, Japan
    Cell Stem Cell 1:685-97. 2007
    ..Altogether, these observations suggest that THPO/MPL signaling plays a critical role of LT-HSC regulation in the osteoblastic niche...
  7. doi request reprint Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells
    Yumiko Gomei
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan
    Exp Hematol 38:82-9. 2010
    ..Here, we investigated the functional differences between Ang-1 and Ang-2 in the maintenance of HSCs...
  8. doi request reprint Niche regulation of hematopoietic stem cells in the endosteum
    Fumio Arai
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan
    Ann N Y Acad Sci 1176:36-46. 2009
    ....
  9. doi request reprint Cancer stem cells and their niche
    Hiroko Iwasaki
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Tokyo, Japan
    Cancer Sci 100:1166-72. 2009
    ....
  10. ncbi request reprint Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction
    Kentaro Hosokawa
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 363:578-83. 2007
    ..Administration of a potent anti-oxidant, N-acetyl cystein (NAC) suppressed the shift from SP cells. These data suggest that ROS suppressed the N-cadherin-mediated cell adhesion, and induce the exit of HSCs from the niche...
  11. pmc Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL
    Sahoko Matsuoka
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Genes Dev 22:986-91. 2008
    ..Thus, Fbxw7 functions as a fail-safe mechanism against both premature HSC loss and leukemogenesis...