Y Iwakura

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury
    Atsushi Sato
    Department of Anatomy, Showa University School of Medicine, 15 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Neuroinflammation 9:65. 2012
  2. ncbi Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules
    Hiromitsu Teruya
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Retrovirology 5:86. 2008
  3. ncbi CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis
    Soo Hyun Chung
    Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Arthritis Res Ther 12:R188. 2010
  4. ncbi Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors
    Iannis E Adamopoulos
    Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Inc, 901 South California Avenue, Palo Alto, CA 94304, USA
    Arthritis Res Ther 12:R29. 2010
  5. ncbi Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis
    Noriyuki Fujikado
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
    Arthritis Res Ther 8:R100. 2006
  6. ncbi The roles of IL-17A in inflammatory immune responses and host defense against pathogens
    Yoichiro Iwakura
    Center for Experimental Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Immunol Rev 226:57-79. 2008
  7. ncbi The IL-23/IL-17 axis in inflammation
    Yoichiro Iwakura
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Clin Invest 116:1218-22. 2006
  8. ncbi [Mouse models for rheumatoid arthritis and their use in drug development]
    Yoichiro Iwakura
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Nihon Yakurigaku Zasshi 120:303-13. 2002
  9. ncbi Roles of IL-1 in the development of rheumatoid arthritis: consideration from mouse models
    Yoichiro Iwakura
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cytokine Growth Factor Rev 13:341-55. 2002
  10. ncbi Functional specialization of interleukin-17 family members
    Yoichiro Iwakura
    Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Immunity 34:149-62. 2011

Collaborators

Detail Information

Publications125 found, 100 shown here

  1. ncbi Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury
    Atsushi Sato
    Department of Anatomy, Showa University School of Medicine, 15 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Neuroinflammation 9:65. 2012
    ..Moreover, we demonstrated the contribution of IL-1 to both the classical and alternative activation of MG in vitro using an adult MG primary culture...
  2. ncbi Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules
    Hiromitsu Teruya
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Retrovirology 5:86. 2008
    ..However, little is known about induction of these genes by HTLV-I infection in lung epithelial cells...
  3. ncbi CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis
    Soo Hyun Chung
    Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Arthritis Res Ther 12:R188. 2010
    ..In this report, we generated T cell-specific Cxcr4-deficient mice and showed that the CXCR4 in T cells is important for the development of collagen-induced arthritis (CIA)...
  4. ncbi Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors
    Iannis E Adamopoulos
    Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Inc, 901 South California Avenue, Palo Alto, CA 94304, USA
    Arthritis Res Ther 12:R29. 2010
    ..In this paper we describe a new mechanism by which the immune cytokine IL-17A directly affects osteoclastogenesis...
  5. ncbi Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis
    Noriyuki Fujikado
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
    Arthritis Res Ther 8:R100. 2006
    ..Furthermore, we demonstrated that identification of gene clusters by transcriptome mapping is a useful way to find potentially pathogenic genes among genes whose expression change is only marginal...
  6. ncbi The roles of IL-17A in inflammatory immune responses and host defense against pathogens
    Yoichiro Iwakura
    Center for Experimental Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Immunol Rev 226:57-79. 2008
    ..In this review, we introduce how IL-17A/IL-17F are involved in inflammatory immune responses and host defense mechanisms and discuss their relationship with other cytokines in the development of inflammatory and infectious diseases...
  7. ncbi The IL-23/IL-17 axis in inflammation
    Yoichiro Iwakura
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Clin Invest 116:1218-22. 2006
    ..These studies suggest that the IL-23/IL-17 pathway may be a novel therapeutic target for the treatment of chronic inflammatory diseases...
  8. ncbi [Mouse models for rheumatoid arthritis and their use in drug development]
    Yoichiro Iwakura
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Nihon Yakurigaku Zasshi 120:303-13. 2002
    ..In this review, the roles of IL-1 in the development of autoimmunity and arthritis will be discussed in correlation with the development of new drugs...
  9. ncbi Roles of IL-1 in the development of rheumatoid arthritis: consideration from mouse models
    Yoichiro Iwakura
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cytokine Growth Factor Rev 13:341-55. 2002
    ..In this review, the roles of IL-1 in the development of autoimmunity and arthritis in mouse models will be discussed...
  10. ncbi Functional specialization of interleukin-17 family members
    Yoichiro Iwakura
    Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Immunity 34:149-62. 2011
    ..The functions of IL-17B, IL-17C, and IL-17D remain largely elusive. In this review, we describe the identified functions of each IL-17 family member and discuss the potential of these molecules as therapeutic targets...
  11. ncbi The development of autoimmune inflammatory arthropathy in mice transgenic for the human T cell leukemia virus type-1 env-pX region is not dependent on H-2 haplotypes and modified by the expression levels of Fas antigen
    Y Iwakura
    Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Japan
    J Immunol 161:6592-8. 1998
    ..These observations suggest that aberration of Fas-mediated apoptosis of peripheral lymphocytes, rather than negative selection in the thymus, is involved in the development of autoimmune arthropathy in pX-Tg mice...
  12. ncbi [The role of IL-1 in the development of autoimmunity]
    Yoichiro Iwakura
    Tanpakushitsu Kakusan Koso 47:2349-54. 2002
  13. ncbi IL-1 enhances T cell-dependent antibody production through induction of CD40 ligand and OX40 on T cells
    S Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 167:90-7. 2001
    ..These observations indicate that IL-1 enhances T cell-dependent Ab production by augmenting CD40 ligand and OX40 expression on T cells...
  14. ncbi Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice
    R Horai
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Exp Med 191:313-20. 2000
    ..Possible involvement of IL-1ra gene deficiency in RA will be discussed...
  15. ncbi IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity
    S Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 13:1471-8. 2001
    ..These observations indicate that IL-1alpha, but not IL-1beta, plays a crucial role in TNCB-induced CHS by sensitizing TNP-specific T cells...
  16. ncbi Interleukin-1 beta, but not interleukin-1 alpha, is required for T-cell-dependent antibody production
    S Nakae
    Centre for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Immunology 104:402-9. 2001
    ..These results show that endogenous IL-1 beta, but not IL-1 alpha, is involved in T-cell-dependent antibody production, and IL-1 promotes the antigen-specific T-cell helper function through the T-cell-APC interaction...
  17. ncbi Involvement of autoimmunity against type II collagen in the development of arthritis in mice transgenic for the human T cell leukemia virus type I tax gene
    M Kotani
    Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Japan
    Eur J Immunol 29:54-64. 1999
    ..These observations show that endogenous IIC is one of the arthritogenic antigens in the joint, suggesting tolerance break to this antigen in pX-transgenic mice...
  18. ncbi Knockout of mouse beta 1,4-galactosyltransferase-1 gene results in a dramatic shift of outer chain moieties of N-glycans from type 2 to type 1 chains in hepatic membrane and plasma glycoproteins
    N Kotani
    Division of Biochemistry, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochem J 357:827-34. 2001
    ..The knockout mice may prove useful in investigation of the mechanism which regulates the tissue-dependent terminal glycosylation...
  19. ncbi Cloning of a novel 2',5'-oligoadenylate synthetase-like molecule, Oasl5 in mice
    S Shibata
    Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Gene 271:261-71. 2001
    ..These findings suggest a novel function of Oasl5, which are independent of oligoadenylate synthetase activity, in the brain and developing embryos...
  20. ncbi IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist
    Susumu Nakae
    Center for Experimental Medicine and Department of Cancer Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 100:5986-90. 2003
    ..These observations suggest that IL-17 plays a crucial role in T cell activation, downstream of IL-1, causing the development of autoimmune arthritis...
  21. ncbi Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1
    C Naruse-Nakajima
    Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, 108 8639, Tokyo, Japan
    Mech Dev 102:95-105. 2001
    ..These observations suggest that EphA2 and its ligands are involved in the positioning of the tail notochord through repulsive signals between cells expressing these molecules on the surface...
  22. ncbi Monoallelic expression of the odourant receptor gene and axonal projection of olfactory sensory neurones
    T Ishii
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
    Genes Cells 6:71-8. 2001
    ..The segregation was more prominent with increased differences in the genetic background between the two alleles...
  23. ncbi TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice
    Reiko Horai
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Clin Invest 114:1603-11. 2004
    ..These findings suggest that IL-1 receptor antagonist deficiency in T cells disrupts homeostasis of the immune system and that TNF-alpha plays an important role in activating T cells through induction of OX40...
  24. ncbi Involvement of interleukin-1 in lipopolysaccaride-induced microglial activation and learning and memory deficits
    S Tanaka
    Department of Biochemical Toxicology, School of Pharmacy, Showa University, Tokyo, Japan
    J Neurosci Res 89:506-14. 2011
    ..These findings suggest that the expression of interleukin-1 plays an important role in lipopolysaccharide-induced activation of microglia and the associated functional deficits in learning and memory...
  25. ncbi Suppression of autoimmune arthritis in interleukin-1-deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells
    Shinobu Saijo
    Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Arthritis Rheum 46:533-44. 2002
    ....
  26. ncbi Mutually exclusive expression of odorant receptor transgenes
    S Serizawa
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo 113 0032, Japan
    Nat Neurosci 3:687-93. 2000
    ..Such an unusual mode of gene expression, monoallelic and mutually exclusive, has previously been shown only for the antigen-receptor genes of the immune system...
  27. ncbi TAG-1-deficient mice have marked elevation of adenosine A1 receptors in the hippocampus
    F Fukamauchi
    Department of Molecular Medical Science, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10, Kandasurugadai, Chiyoda ku, Tokyo, 101 0062, Japan
    Biochem Biophys Res Commun 281:220-6. 2001
    ..We suspect that the subtle changes in neural plasticity induced by TAG-1 deficiency during development cause the selective vulnerability of specific brain regions and the epileptogenicity in TAG-1 (-/-) mice...
  28. ncbi Murine coronavirus-induced subacute fatal peritonitis in C57BL/6 mice deficient in gamma interferon
    S Kyuwa
    Department of Animal Pathology, Institute of Medical Science, University of Tokyo, Tokyo 108, Japan
    J Virol 72:9286-90. 1998
    ..They also show that a resultant persistent JHMV infection induces another form of disease in IFN-gamma-/- mice, which bears a resemblance to feline infectious peritonitis in cats...
  29. ncbi Roles of CD4(+) T cells and gamma interferon in protective immunity against Babesia microti infection in mice
    I Igarashi
    The Research Center for Protozoan Molecular Immunology, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Maebashi, The University of Tokyo, Tokyo, Japan
    Infect Immun 67:4143-8. 1999
    ..These results suggest essential requirements for CD4(+) T cells and IFN-gamma in protective immunity against challenge infection with B. microti...
  30. ncbi A critical role of Fc receptor-mediated antibody-dependent phagocytosis in the host resistance to blood-stage Plasmodium berghei XAT infection
    T Yoneto
    Department of Allergology and Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 166:6236-41. 2001
    ..These results suggest that FcR-mediated Ab-dependent phagocytosis, which is located downstream of IFN-gamma production, is important as an effector mechanism to eliminate PRBC in blood-stage P. berghei XAT infection...
  31. ncbi [Interleukin-1 in pathogenesis of rheumatoid arthritis]
    Yoichiro Iwakura
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo
    Nippon Rinsho 63:153-7. 2005
  32. ncbi T cell apoptosis causes peripheral T cell depletion in mice transgenic for the HIV-1 vpr gene
    J Yasuda
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Virology 285:181-92. 2001
    ..Involvement of Bcl-x, Bax, and Caspase-1, but not of the Fas-Fas ligand system, was suggested in the apoptotic processes. These observations suggest that Vpr is involved in the pathogenesis of T cell depletion in HIV-infected people...
  33. ncbi Latent HIV-1 reactivation in transgenic mice requires cell cycle -dependent demethylation of CREB/ATF sites in the LTR
    J Tanaka
    Center for Experimental Medicine and the Department of Cancer Research, Institute of Medical Science, University of Tokyo, Japan
    AIDS 17:167-75. 2003
    ..CONCLUSIONS: These observations indicate that cell cycle progression-dependent demethylation of the CREB/ATF sites in the LTR is crucial for the reactivation of latent HIV-1 genome in transgenic mice...
  34. ncbi Suppression of oxidative stress after transient focal ischemia in interleukin-1 knock out mice
    H Ohtaki
    Department of Anatomy, Showa University School of Medicine, Tokyo, Japan
    Acta Neurochir Suppl 86:191-4. 2003
    ..These results strongly suggest that IL-1 is participated in generating reactive oxygen spices and it aggravates and induces the ischemic neuronal cell death.(183 words)...
  35. ncbi A novel transcriptional regulatory factor that binds to the polyoma virus enhancer in a developmental stage-specific manner
    T Hirano
    Institute of Medical Science, University of Tokyo, Japan
    Biochimie 72:327-36. 1990
    ..These observations suggest that BF-H regulates the expression of genes in a developmental stage-specific manner in early embryos of the mouse...
  36. ncbi Generation of polymeric immunoglobulin receptor-deficient mouse with marked reduction of secretory IgA
    S Shimada
    Yakult Central Institute for Microbiological Research, Tokyo, Japan
    J Immunol 163:5367-73. 1999
    ..These results demonstrate that dIgA is mainly transported by pIgR on the epithelial cells of intestine and hepatocytes, but a small quantity of IgA may be secreted via other pathways...
  37. ncbi Role of interferon-gamma in inflammatory responses in murine respiratory infection with Legionella pneumophila
    Yoko Shinozawa
    Second Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
    J Med Microbiol 51:225-30. 2002
    ..The findings suggest that retardation of host immune responses, including inflammatory cytokine production caused by deficiency of IFN-gamma, might allow the bacteria to grow and cause fulminant pneumonia...
  38. ncbi Involvement of tumor necrosis factor-alpha in the development of T cell-dependent aortitis in interleukin-1 receptor antagonist-deficient mice
    Taizo Matsuki
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai 4 6 1, Tokyo 108 8639, Japan
    Circulation 112:1323-31. 2005
    ..These mice also frequently develop aortitis at the root of the aorta, but the mechanism underlying the development of this disease has not been completely elucidated...
  39. ncbi Immunogenicity of Peptide-25 of Ag85B in Th1 development: role of IFN-gamma
    Ai Kariyone
    Division of Immunology, Department of Microbiology and Immunology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
    Int Immunol 15:1183-94. 2003
    ....
  40. ncbi IL-1beta, but not IL-1alpha, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses
    Aya Nambu
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai, Tokyo 108 8639, Japan
    Int Immunol 18:701-12. 2006
    ..In addition, CD4+ T cell-derived IL-1 plays an important role in the activation of DCs during the elicitation phase, resulting in the production of TNF, that activate allergen-specific T cells...
  41. ncbi Protective roles of mast cells and mast cell-derived TNF in murine malaria
    Takahisa Furuta
    Department of Microbiology and Immunology, Division of Infectious Genetics, University of Tokyo, Japan
    J Immunol 177:3294-302. 2006
    ..These findings propose a novel mechanism that mast cells and mast cell-derived TNF play protective roles in malaria...
  42. ncbi Age-dependent regulation of depression-like behaviors through modulation of adrenergic receptor α₁A subtype expression revealed by the analysis of interleukin-1 receptor antagonist knockout mice
    C Wakabayashi
    Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Neuroscience 192:475-84. 2011
    ....
  43. ncbi Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice
    N Uetani
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    EMBO J 19:2775-85. 2000
    ..To our knowledge, this is the first report of a specific PTP involved in the regulation of synaptic plasticity or in the processes regulating learning and memory...
  44. ncbi Normal levels of serum glycoproteins maintained in beta-1, 4-galactosyltransferase I-knockout mice
    M Kido
    Department of Biosignal Research, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    FEBS Lett 464:75-9. 1999
    ..The results indicate that the hepatic asialoglycoprotein receptor-mediated system is not functioning in the clearance of endogenous serum glycoproteins...
  45. ncbi Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion
    R Horai
    Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108, Japan
    J Exp Med 187:1463-75. 1998
    ..The importance of IL-1ra both in normal physiology and under stress is also suggested...
  46. ncbi Increased fat:carbohydrate oxidation ratio in Il1ra (-/-) mice on a high-fat diet is associated with increased sympathetic tone
    D Chida
    Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Diabetologia 51:1698-706. 2008
    ..The present study was designed to analyse the mechanisms leading to this lean phenotype...
  47. ncbi Anti-type II collagen antibody accelerates arthritis via CXCR2-expressing cells in IL-1 receptor antagonist-deficient mice
    Takashi Kagari
    Biological Research Laboratories, Daiichi Sankyo Co Ltd, Tokyo, Japan
    Eur J Immunol 37:2753-63. 2007
    ....
  48. ncbi Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells
    Noriyuki Fujikado
    Center for Experimental Medicine, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Med 14:176-80. 2008
    ..These observations indicate that Dcir is a negative regulator of DC expansion and has a crucial role in maintaining the homeostasis of the immune system...
  49. ncbi IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    Yutaka Komiyama
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Immunol 177:566-73. 2006
    ..These observations indicate that IL-17 rather than IFN-gamma plays a crucial role in the development of EAE...
  50. ncbi Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II collagen antibody-induced arthritis
    Akinori Okumura
    National Institute of Infectious Diseases, Tokyo, Japan
    Arthritis Rheum 58:413-21. 2008
    ..To define the role of LECT2 in inflammatory arthritides, we investigated the development of collagen antibody-induced arthritis (CAIA) in LECT2-deficient (LECT2(-/-)) mice...
  51. ncbi Role of Crk-associated substrate lymphocyte type in the pathophysiology of rheumatoid arthritis in tax transgenic mice and in humans
    Rikako Miyake-Nishijima
    Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Arthritis Rheum 48:1890-900. 2003
    ..To investigate the role of Crk-associated substrate lymphocyte type (Cas-L), a downstream signaling molecule of beta1 integrins, in the pathophysiology of rheumatoid arthritis (RA)...
  52. ncbi Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Immunity 17:375-87. 2002
    ..Our findings indicate that IL-17 plays an important role in activating T cells in allergen-specific T cell-mediated immune responses...
  53. ncbi Essential role of MD-2 in LPS responsiveness and TLR4 distribution
    Yoshinori Nagai
    Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Immunol 3:667-72. 2002
    ..Thus, MD-2 is essential for correct intracellular distribution and LPS-recognition of TLR4...
  54. ncbi Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 171:6173-7. 2003
    ..Thus, these observations suggest that IL-17 plays a crucial role in the development of CIA by activating autoantigen-specific cellular and humoral immune responses...
  55. ncbi IL-1-induced tumor necrosis factor-alpha elicits inflammatory cell infiltration in the skin by inducing IFN-gamma-inducible protein 10 in the elicitation phase of the contact hypersensitivity response
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
    Int Immunol 15:251-60. 2003
    ..Reduced CHS in TNF-alpha(-/-) mice was reversed by IP-10 injection during the elicitation phase. Thus, it was shown that the roles for IL-1 and TNF-alpha are different, although both cytokines are crucial for the development of CHS...
  56. ncbi Involvement of tumor necrosis factor alpha, rather than interleukin-1alpha/beta or nitric oxides in the heme oxygenase-1 gene expression by lipopolysaccharide in the mouse liver
    Takiko Oguro
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, 142 8555, Tokyo, Japan
    FEBS Lett 516:63-6. 2002
    ..All of these findings indicate that TNFalpha is a major candidate to trigger HO-1 induction in response to LPS stimulation, and that its message is likely transduced through JNK and p38 pathways...
  57. ncbi Impaired galactosylation of core 2 O-glycans in erythrocytes of beta1,4-galactosyltransferase knockout mice
    N Kotani
    Department of Biochemistry, University of Tokyo, Tokyo, 108 8639, Japan
    Biochem Biophys Res Commun 260:94-8. 1999
    ..Thus, it is suggested that GalT-I is predominantly responsible for beta1,4-galactosylation of the core 2 O-glycan branch in erythroid cells...
  58. ncbi Interleukin-1-deficient mice exhibit high sensitivity to gut-derived sepsis caused by Pseudomonas aeruginosa
    Tetsuya Horino
    Department of Internal Medicine, Jikei University School of Medicine, Nishi Shimbashi, Minato ku, Tokyo, Japan
    Cytokine 30:339-46. 2005
    ..We evaluated the role of endogenous IL-1 in gut-derived sepsis caused by Pseudomonas aeruginosa, by comparing IL-1-deficient mice and wild-type (WT) mice...
  59. ncbi Systemic administration of IL-23 induces potent antitumor immunity primarily mediated through Th1-type response in association with the endogenously expressed IL-12
    Teruo Kaiga
    Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 461 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    J Immunol 178:7571-80. 2007
    ....
  60. ncbi Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis
    Taizo Matsuki
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 18:399-407. 2006
    ..These observations suggest that the IL-1/IL-1Ra system is crucial for auto-antigen-specific T cell induction and contributes to the development of EAE...
  61. ncbi Peripheral TNFalpha, but not peripheral IL-1, requires endogenous IL-1 or TNFalpha induction in the brain for the febrile response
    Dai Chida
    Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 364:765-70. 2007
    ....
  62. ncbi Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Tokyo, Japan
    Eur J Pharmacol 558:199-207. 2007
    ....
  63. ncbi TNF, but not IL-6 and IL-17, is crucial for the development of T cell-independent psoriasis-like dermatitis in Il1rn-/- mice
    Akiko Nakajima
    Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Immunol 185:1887-93. 2010
    ..These observations suggest that excess IL-1 signaling directly activates keratinocytes to produce TNF and chemokines, resulting in the development of psoriasis-like skin lesions without the involvement of autoimmunity in Il1rn(-/-) mice...
  64. ncbi Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A
    Naoko Okiyama
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 60:2505-12. 2009
    ..To explore new molecular targets in the treatment of polymyositis (PM) by examining a recently established murine model of PM, C protein-induced myositis (CIM), for involvement of an interleukin-6 (IL-6)/IL-17A pathway...
  65. ncbi Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses
    Harumichi Ishigame
    Center for Experimental Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Immunity 30:108-19. 2009
    ..These observations indicate that IL-17A and IL-17F have overlapping yet distinct roles in host immune and defense mechanisms...
  66. ncbi Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes
    Y Tagawa
    Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Japan
    J Immunol 159:1418-28. 1997
    ..These observations suggest that IFN-gamma plays a central role in Con A-hepatitis by activating Fas-induced apoptosis of liver cells...
  67. ncbi Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages
    Masato Murakami
    Division of Genetics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    Blood 108:1849-56. 2006
    ....
  68. ncbi A new murine model to define the critical pathologic and therapeutic mediators of polymyositis
    Takahiko Sugihara
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 56:1304-14. 2007
    ..To establish a new murine model of polymyositis (PM) for the understanding of its pathologic mechanisms and the development of new treatment strategies...
  69. ncbi Interleukin-1 deficiency in combination with macrophage depletion increases susceptibility to Pseudomonas aeruginosa bacteremia
    Tetsuya Horino
    Department of Infectious Disease and Infection Control, The Jikei University School of Medicine, 3 19 18 Nishi Shimbashi, Minato ku, Tokyo, Japan
    Microbiol Immunol 53:502-11. 2009
    ..Thus, IL-1 deficiency becomes disadvantageous during P. aeruginosa bacteremia when it is accompanied by immunosuppression, particularly when macrophage functions are seriously impaired...
  70. ncbi The mechanism of LPS-induced HIV type I activation in transgenic mouse macrophages
    Motohiko Kadoki
    Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato ku, Tokyo, Japan
    Int Immunol 22:469-78. 2010
    ....
  71. ncbi Pathological changes of renal epithelial cells in mice transgenic for the TT virus ORF1 gene
    Hiroshi Yokoyama
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
    J Gen Virol 83:141-50. 2002
    ..These observations suggest that TTV affects renal epithelial cells as part of the naturally occurring infection...
  72. ncbi Role of interferon-gamma in the development of murine bronchus-associated lymphoid tissues induced by silica in vivo
    Masashi Desaki
    Department of Respiratory Medicine, Graduate School of Medicine, Instutute of Medical Science, University of Tokyo, Tokyo, Japan
    Toxicol Appl Pharmacol 185:1-7. 2002
    ..These results suggest that IFN-gamma has an inhibitory effect on the development of BALT and may be involved in small airway disease in silicotic lung...
  73. ncbi Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans
    Shinobu Saijo
    Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku Tokyo 108 8639, Japan
    Immunity 32:681-91. 2010
    ..Because IL-17A-deficient mice were highly susceptible to systemic candida infection, this study suggests that Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation...
  74. ncbi Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour
    Sachiko Taniguchi
    Division of Oncology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    EMBO J 28:3717-29. 2009
    ..These data argue that Tyr 1325 phosphorylation regulates NMDA receptor channel properties and the NMDA receptor-mediated downstream signalling to modulate depression-related behaviour...
  75. ncbi Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury
    Takashi Shichita
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    Nat Med 15:946-50. 2009
    ..We propose that T lymphocytes, including gammadeltaT lymphocytes, could be a therapeutic target for mitigating the inflammatory events that amplify the initial damage in cerebral ischemia...
  76. ncbi IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 15:483-90. 2003
    ..These observations indicate that IL-1 plays important roles in the development of AHR...
  77. ncbi IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions
    Taizo Matsuki
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Exp Med 198:877-88. 2003
    ..These observations suggest that IL-1 plays an important role in lipid metabolism by regulating insulin levels and lipase activity under physiological conditions...
  78. ncbi Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans
    Shinobu Saijo
    Center for Experimental Medicine, The Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Immunol 8:39-46. 2007
    ..Thus, dectin-1 is required for immune responses to some fungal infections, as protective immunity to pneumocystis, but not to candida, required dectin-1 for the production of antifungal reactive oxygen species...
  79. ncbi Functional hypothalamic amenorrhea due to increased CRH tone in melanocortin receptor 2-deficient mice
    Takashi Matsuwaki
    Department of Veterinary Physiology, The University of Tokyo, Tokyo, Japan
    Endocrinology 151:5489-96. 2010
    ..Our findings show that high levels of hypothalamic CRH disturb estrous cyclicity in the female animals and that the MC2R(-/-) female is a unique animal model of functional hypothalamic amenorrhea...
  80. ncbi Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation
    Akane Inoue
    Division of Genetics and Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Sci Signal 2:ra7. 2009
    ..These observations indicate that Dok-7 positively regulates neuromuscular synaptogenesis by controlling MuSK activity, its distribution, and its responsiveness to neural agrin...
  81. ncbi Kid-mediated chromosome compaction ensures proper nuclear envelope formation
    Miho Ohsugi
    Division of Oncology, Department of Cancer Biology, The University of Tokyo, Minato ku, Tokyo, 108 8639, Japan
    Cell 132:771-82. 2008
    ..This protection is especially important during the very early stages of development, when the embryonic cells are rich in ooplasm...
  82. ncbi Combined interleukin-6 and interleukin-1 deficiency causes obesity in young mice
    Dai Chida
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Toyko 108 8639, Japan
    Diabetes 55:971-7. 2006
    ..These results indicate that IL-1 and IL-6 are both involved in the regulation of body fat in a redundant manner in young mice...
  83. ncbi Induction of IgG2a class switching in B cells by IL-27
    Takayuki Yoshimoto
    Intractable Immune System Disease Research Center, Tokyo Medical University, Tokyo, Japan
    J Immunol 173:2479-85. 2004
    ..Thus, IL-27 may be a novel attractive candidate as a therapeutic agent against diseases such as allergic disorders by not only regulating Th1 differentiation but also directly acting on B cells and inducing IgG2a class switching...
  84. ncbi Inhibition of B16 melanoma experimental metastasis by interferon-gamma through direct inhibition of cell proliferation and activation of antitumour host mechanisms
    Shigeru Kakuta
    Center for Experimental Medicine, Insitute of Medical Science, University of Tokyo, Tokyo, Japan
    Immunology 105:92-100. 2002
    ..These observations suggest that IFN-gamma prevents B16 melanoma experimental metastasis by directly inhibiting the cell growth, although antitumour host functions may also be involved in a later phase...
  85. ncbi Polylactosamine synthesis and branch formation of N-glycans in beta1,4-galactosyltransferase-1-deficient mice
    Norihiro Kotani
    Division of Biochemistry, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Arch Biochem Biophys 426:258-65. 2004
    ..These results suggest that beta4GalT-1 expressed in erythroid cells may regulate a constant branch formation of N-glycans and plays a predominant role in beta1,4-galactosylation of core 2 O-glycan...
  86. ncbi Involvement of corticotropin-releasing hormone- and interleukin (IL)-6-dependent proopiomelanocortin induction in the anterior pituitary during hypothalamic-pituitary-adrenal axis activation by IL-1alpha
    Dai Chida
    Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Japan
    Endocrinology 146:5496-502. 2005
    ..Our results suggest a role for IL-1alpha/beta in the induction of POMC in the AP through the induction of two independent pathways, CRH and IL-6...
  87. ncbi Interleukin (IL)-6, but not IL-1, induction in the brain downstream of cyclooxygenase-2 is essential for the induction of febrile response against peripheral IL-1alpha
    Kyoko Kagiwada
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Endocrinology 145:5044-8. 2004
    ..These observations suggest a mechanism of IL-1-induced febrile response in which IL-1 in the blood activates Cox-2, with the resulting prostaglandin E(2) inducing IL-6 in the brain, leading to the development of fever...
  88. ncbi Diurnal variation of heart rate, locomotor activity, and body temperature in interleukin-1 alpha/beta doubly deficient mice
    Masashi Furuzawa
    Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Exp Anim 51:49-56. 2002
    ..These results suggest that IL-1 may play important physiological and pathophysiological roles on biobehavioral activities...
  89. ncbi Interleukin-1beta abrogates long-term depression of hippocampal CA1 synaptic transmission
    Yuji Ikegaya
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    Synapse 47:54-7. 2003
    ..These results suggest that IL-1beta-induced, persistent depression of synaptic efficacy is required for GABAergic activation and shares, at least in part, a common cellular mechanism for LTD...
  90. ncbi Suppression of oxidative neuronal damage after transient middle cerebral artery occlusion in mice lacking interleukin-1
    Hirokazu Ohtaki
    Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, 142-8555, Tokyo, Japan
    Neurosci Res 45:313-24. 2003
    ..These results indicate that IL-1 is up-regulated and may play a role in neurodegeneration by peroxynitrite production during ischemia...
  91. ncbi Protection against influenza virus infection in polymeric Ig receptor knockout mice immunized intranasally with adjuvant-combined vaccines
    Yasuko Asahi
    Department of Pathology, National Institute of Infectious Diseases, Yakult Central Institute for Microbiological Research, and Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 168:2930-8. 2002
    ....
  92. ncbi Nuclear import of the preintegration complex is blocked upon infection by human immunodeficiency virus type 1 in mouse cells
    Naomi Tsurutani
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Tokyo 108 8639, Japan
    J Virol 81:677-88. 2007
    ..On the other hand, GFP-Vpr localized exclusively to the nuclei of both mouse and human cells. These observations suggest that, due to the dysfunction of integrase, the nuclear localization of PIC is suppressed in mouse cells...
  93. ncbi Involvement of IL-1 family proteins in p38 linked cellular senescence of mouse embryonic fibroblasts
    Natsuko Uekawa
    Laboratory of Experimental Animal Model Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36 3, Gengo, Morioka cho, Obu City, Aichi 474 8522, Japan
    FEBS Lett 575:30-4. 2004
    ..We also found a distinguishable accelerated senescence in cell growth in IL-1Ra deficient MEFs culture. Our results suggest that IL-1beta signaling pathway is involved in activation of p38 linked cellular senescence...
  94. ncbi Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction
    Leo A B Joosten
    Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Am J Pathol 165:959-67. 2004
    ..These findings implicate that IL-18, in contrast to TNF, contributes through separate pathways to joint inflammation and cartilage destruction...
  95. ncbi IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation
    Sung Joo Park
    Department of Molecular Oncology, Graduate School of Medicine, Osaka University, Suita, Japan
    J Immunol 173:3844-54. 2004
    ..IL-6 is thus a potent regulator of DC differentiation in vivo, and IL-6-gp130-STAT3 signaling in DCs may represent a critical target for controlling T cell-mediated immune responses in vivo...
  96. ncbi Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category
    Dror Luger
    Laboratory of Immunology, National Eye Institute NEI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 205:799-810. 2008
    ..These data also raise the possibility that the nonredundant requirement for IL-23 in EAU may extend beyond its role in promoting the Th17 effector response and help provide a balance in the current Th1 versus Th17 paradigm...
  97. ncbi Involvement of IL-17 in Fas ligand-induced inflammation
    Masayuki Umemura
    Center for the Development of Molecular Target Drugs, Cancer Research Institute, Graduate School of Medicine Science, Kanazawa University, Takaramachi, Japan
    Int Immunol 16:1099-108. 2004
    ..These results indicate that FasL is an upstream inflammatory factor that induces a variety of other inflammatory cytokines in vivo, and suggest that IL-17 is involved in FasL-induced inflammation in the absence of IL-1beta...
  98. ncbi Blocking of IL-6 signaling pathway prevents CD4+ T cell-mediated colitis in a T(h)17-independent manner
    Daisuke Noguchi
    Division of Immunoregulation Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Int Immunol 19:1431-40. 2007
    ..Thus, the IL-6-mediated signaling pathway may be a significant therapeutic target in T cell-mediated autoimmune diseases...
  99. ncbi Histamine production via mast cell-independent induction of histidine decarboxylase in response to lipopolysaccharide and interleukin-1
    Xia Wu
    Department of Oral Diagnosis, Graduate School of Dentistry, Tohoku University, 4-1, Seiryo-machi, Aoba, Sendai 980-8575, Japan
    Int Immunopharmacol 4:513-20. 2004
    ....
  100. ncbi Panax ginseng induces production of proinflammatory cytokines via toll-like receptor
    Taka Aki Nakaya
    Department of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Interferon Cytokine Res 24:93-100. 2004
    ..These results suggest that GRE contains a non-LPS agent that enhances innate immunity through production of proinflammatory cytokines via TLR-4...
  101. ncbi The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis
    Katsuhiko Ishihara
    Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
    Int Immunol 16:455-65. 2004
    ..gp130F759/F759/pX-Tg is a unique mouse model for RA...