Y Iwakura

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice
    R Horai
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Exp Med 191:313-20. 2000
  2. pmc IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions
    Taizo Matsuki
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Exp Med 198:877-88. 2003
  3. pmc IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice
    Etsuko Kurimoto
    Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Respir Res 14:5. 2013
  4. pmc Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1α-dependent in mice
    Fernando M Botelho
    Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada
    Respir Res 13:81. 2012
  5. pmc Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury
    Atsushi Sato
    Department of Anatomy, Showa University School of Medicine, 15 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Neuroinflammation 9:65. 2012
  6. pmc Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules
    Hiromitsu Teruya
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Retrovirology 5:86. 2008
  7. pmc CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis
    Soo Hyun Chung
    Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Arthritis Res Ther 12:R188. 2010
  8. pmc Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors
    Iannis E Adamopoulos
    Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Inc, 901 South California Avenue, Palo Alto, CA 94304, USA
    Arthritis Res Ther 12:R29. 2010
  9. pmc Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis
    Noriyuki Fujikado
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Arthritis Res Ther 8:R100. 2006
  10. doi request reprint The roles of IL-17A in inflammatory immune responses and host defense against pathogens
    Yoichiro Iwakura
    Center for Experimental Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Immunol Rev 226:57-79. 2008

Collaborators

Detail Information

Publications128 found, 100 shown here

  1. pmc Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice
    R Horai
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Exp Med 191:313-20. 2000
    ..Possible involvement of IL-1ra gene deficiency in RA will be discussed...
  2. pmc IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions
    Taizo Matsuki
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Exp Med 198:877-88. 2003
    ..These observations suggest that IL-1 plays an important role in lipid metabolism by regulating insulin levels and lipase activity under physiological conditions...
  3. pmc IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice
    Etsuko Kurimoto
    Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Respir Res 14:5. 2013
    ..Although IL-17A contributes to many chronic inflammatory diseases, it's role in the inflammatory response of elastase-induced emphysema remains unclear...
  4. pmc Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1α-dependent in mice
    Fernando M Botelho
    Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada
    Respir Res 13:81. 2012
    ..We investigated the importance of IL-1R1 and its ligands IL-1α and β to dendritic cell accumulation and maturation in response to cigarette smoke exposure...
  5. pmc Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury
    Atsushi Sato
    Department of Anatomy, Showa University School of Medicine, 15 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Neuroinflammation 9:65. 2012
    ..Moreover, we demonstrated the contribution of IL-1 to both the classical and alternative activation of MG in vitro using an adult MG primary culture...
  6. pmc Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules
    Hiromitsu Teruya
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Retrovirology 5:86. 2008
    ..However, little is known about induction of these genes by HTLV-I infection in lung epithelial cells...
  7. pmc CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis
    Soo Hyun Chung
    Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Arthritis Res Ther 12:R188. 2010
    ..In this report, we generated T cell-specific Cxcr4-deficient mice and showed that the CXCR4 in T cells is important for the development of collagen-induced arthritis (CIA)...
  8. pmc Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors
    Iannis E Adamopoulos
    Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Inc, 901 South California Avenue, Palo Alto, CA 94304, USA
    Arthritis Res Ther 12:R29. 2010
    ..In this paper we describe a new mechanism by which the immune cytokine IL-17A directly affects osteoclastogenesis...
  9. pmc Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis
    Noriyuki Fujikado
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Arthritis Res Ther 8:R100. 2006
    ..Furthermore, we demonstrated that identification of gene clusters by transcriptome mapping is a useful way to find potentially pathogenic genes among genes whose expression change is only marginal...
  10. doi request reprint The roles of IL-17A in inflammatory immune responses and host defense against pathogens
    Yoichiro Iwakura
    Center for Experimental Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Immunol Rev 226:57-79. 2008
    ..In this review, we introduce how IL-17A/IL-17F are involved in inflammatory immune responses and host defense mechanisms and discuss their relationship with other cytokines in the development of inflammatory and infectious diseases...
  11. ncbi request reprint [Mouse models for rheumatoid arthritis and their use in drug development]
    Yoichiro Iwakura
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Nihon Yakurigaku Zasshi 120:303-13. 2002
    ..In this review, the roles of IL-1 in the development of autoimmunity and arthritis will be discussed in correlation with the development of new drugs...
  12. ncbi request reprint [The role of IL-1 in the development of autoimmunity]
    Yoichiro Iwakura
    Tanpakushitsu Kakusan Koso 47:2349-54. 2002
  13. ncbi request reprint Roles of IL-1 in the development of rheumatoid arthritis: consideration from mouse models
    Yoichiro Iwakura
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cytokine Growth Factor Rev 13:341-55. 2002
    ..In this review, the roles of IL-1 in the development of autoimmunity and arthritis in mouse models will be discussed...
  14. doi request reprint Functional specialization of interleukin-17 family members
    Yoichiro Iwakura
    Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Immunity 34:149-62. 2011
    ..The functions of IL-17B, IL-17C, and IL-17D remain largely elusive. In this review, we describe the identified functions of each IL-17 family member and discuss the potential of these molecules as therapeutic targets...
  15. pmc The IL-23/IL-17 axis in inflammation
    Yoichiro Iwakura
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Clin Invest 116:1218-22. 2006
    ..These studies suggest that the IL-23/IL-17 pathway may be a novel therapeutic target for the treatment of chronic inflammatory diseases...
  16. ncbi request reprint The development of autoimmune inflammatory arthropathy in mice transgenic for the human T cell leukemia virus type-1 env-pX region is not dependent on H-2 haplotypes and modified by the expression levels of Fas antigen
    Y Iwakura
    Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Japan
    J Immunol 161:6592-8. 1998
    ..These observations suggest that aberration of Fas-mediated apoptosis of peripheral lymphocytes, rather than negative selection in the thymus, is involved in the development of autoimmune arthropathy in pX-Tg mice...
  17. ncbi request reprint IL-1 enhances T cell-dependent antibody production through induction of CD40 ligand and OX40 on T cells
    S Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 167:90-7. 2001
    ..These observations indicate that IL-1 enhances T cell-dependent Ab production by augmenting CD40 ligand and OX40 expression on T cells...
  18. ncbi request reprint IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity
    S Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 13:1471-8. 2001
    ..These observations indicate that IL-1alpha, but not IL-1beta, plays a crucial role in TNCB-induced CHS by sensitizing TNP-specific T cells...
  19. pmc Interleukin-1 beta, but not interleukin-1 alpha, is required for T-cell-dependent antibody production
    S Nakae
    Centre for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Immunology 104:402-9. 2001
    ..These results show that endogenous IL-1 beta, but not IL-1 alpha, is involved in T-cell-dependent antibody production, and IL-1 promotes the antigen-specific T-cell helper function through the T-cell-APC interaction...
  20. pmc Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion
    R Horai
    Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108, Japan
    J Exp Med 187:1463-75. 1998
    ..The importance of IL-1ra both in normal physiology and under stress is also suggested...
  21. ncbi request reprint Involvement of autoimmunity against type II collagen in the development of arthritis in mice transgenic for the human T cell leukemia virus type I tax gene
    M Kotani
    Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Japan
    Eur J Immunol 29:54-64. 1999
    ..These observations show that endogenous IIC is one of the arthritogenic antigens in the joint, suggesting tolerance break to this antigen in pX-transgenic mice...
  22. pmc Knockout of mouse beta 1,4-galactosyltransferase-1 gene results in a dramatic shift of outer chain moieties of N-glycans from type 2 to type 1 chains in hepatic membrane and plasma glycoproteins
    N Kotani
    Division of Biochemistry, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochem J 357:827-34. 2001
    ..The knockout mice may prove useful in investigation of the mechanism which regulates the tissue-dependent terminal glycosylation...
  23. ncbi request reprint Cloning of a novel 2',5'-oligoadenylate synthetase-like molecule, Oasl5 in mice
    S Shibata
    Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Gene 271:261-71. 2001
    ..These findings suggest a novel function of Oasl5, which are independent of oligoadenylate synthetase activity, in the brain and developing embryos...
  24. pmc IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist
    Susumu Nakae
    Center for Experimental Medicine and Department of Cancer Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 100:5986-90. 2003
    ..These observations suggest that IL-17 plays a crucial role in T cell activation, downstream of IL-1, causing the development of autoimmune arthritis...
  25. ncbi request reprint Monoallelic expression of the odourant receptor gene and axonal projection of olfactory sensory neurones
    T Ishii
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
    Genes Cells 6:71-8. 2001
    ..The segregation was more prominent with increased differences in the genetic background between the two alleles...
  26. ncbi request reprint Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1
    C Naruse-Nakajima
    Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, 108 8639, Tokyo, Japan
    Mech Dev 102:95-105. 2001
    ..These observations suggest that EphA2 and its ligands are involved in the positioning of the tail notochord through repulsive signals between cells expressing these molecules on the surface...
  27. pmc TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice
    Reiko Horai
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Clin Invest 114:1603-11. 2004
    ..These findings suggest that IL-1 receptor antagonist deficiency in T cells disrupts homeostasis of the immune system and that TNF-alpha plays an important role in activating T cells through induction of OX40...
  28. doi request reprint Involvement of interleukin-1 in lipopolysaccaride-induced microglial activation and learning and memory deficits
    S Tanaka
    Department of Biochemical Toxicology, School of Pharmacy, Showa University, Tokyo, Japan
    J Neurosci Res 89:506-14. 2011
    ..These findings suggest that the expression of interleukin-1 plays an important role in lipopolysaccharide-induced activation of microglia and the associated functional deficits in learning and memory...
  29. ncbi request reprint Suppression of autoimmune arthritis in interleukin-1-deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells
    Shinobu Saijo
    Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Arthritis Rheum 46:533-44. 2002
    ....
  30. ncbi request reprint Impaired galactosylation of core 2 O-glycans in erythrocytes of beta1,4-galactosyltransferase knockout mice
    N Kotani
    Department of Biochemistry, University of Tokyo, Tokyo, 108 8639, Japan
    Biochem Biophys Res Commun 260:94-8. 1999
    ..Thus, it is suggested that GalT-I is predominantly responsible for beta1,4-galactosylation of the core 2 O-glycan branch in erythroid cells...
  31. ncbi request reprint Mutually exclusive expression of odorant receptor transgenes
    S Serizawa
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo 113 0032, Japan
    Nat Neurosci 3:687-93. 2000
    ..Such an unusual mode of gene expression, monoallelic and mutually exclusive, has previously been shown only for the antigen-receptor genes of the immune system...
  32. pmc Roles of CD4(+) T cells and gamma interferon in protective immunity against Babesia microti infection in mice
    I Igarashi
    The Research Center for Protozoan Molecular Immunology, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Maebashi, The University of Tokyo, Tokyo, Japan
    Infect Immun 67:4143-8. 1999
    ..These results suggest essential requirements for CD4(+) T cells and IFN-gamma in protective immunity against challenge infection with B. microti...
  33. pmc Murine coronavirus-induced subacute fatal peritonitis in C57BL/6 mice deficient in gamma interferon
    S Kyuwa
    Department of Animal Pathology, Institute of Medical Science, University of Tokyo, Tokyo 108, Japan
    J Virol 72:9286-90. 1998
    ..They also show that a resultant persistent JHMV infection induces another form of disease in IFN-gamma-/- mice, which bears a resemblance to feline infectious peritonitis in cats...
  34. ncbi request reprint TAG-1-deficient mice have marked elevation of adenosine A1 receptors in the hippocampus
    F Fukamauchi
    Department of Molecular Medical Science, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10, Kandasurugadai, Chiyoda ku, Tokyo, 101 0062, Japan
    Biochem Biophys Res Commun 281:220-6. 2001
    ..We suspect that the subtle changes in neural plasticity induced by TAG-1 deficiency during development cause the selective vulnerability of specific brain regions and the epileptogenicity in TAG-1 (-/-) mice...
  35. ncbi request reprint A critical role of Fc receptor-mediated antibody-dependent phagocytosis in the host resistance to blood-stage Plasmodium berghei XAT infection
    T Yoneto
    Department of Allergology and Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 166:6236-41. 2001
    ..These results suggest that FcR-mediated Ab-dependent phagocytosis, which is located downstream of IFN-gamma production, is important as an effector mechanism to eliminate PRBC in blood-stage P. berghei XAT infection...
  36. ncbi request reprint [Interleukin-1 in pathogenesis of rheumatoid arthritis]
    Yoichiro Iwakura
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo
    Nihon Rinsho 63:153-7. 2005
  37. ncbi request reprint Normal levels of serum glycoproteins maintained in beta-1, 4-galactosyltransferase I-knockout mice
    M Kido
    Department of Biosignal Research, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    FEBS Lett 464:75-9. 1999
    ..The results indicate that the hepatic asialoglycoprotein receptor-mediated system is not functioning in the clearance of endogenous serum glycoproteins...
  38. ncbi request reprint T cell apoptosis causes peripheral T cell depletion in mice transgenic for the HIV-1 vpr gene
    J Yasuda
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Virology 285:181-92. 2001
    ..Involvement of Bcl-x, Bax, and Caspase-1, but not of the Fas-Fas ligand system, was suggested in the apoptotic processes. These observations suggest that Vpr is involved in the pathogenesis of T cell depletion in HIV-infected people...
  39. ncbi request reprint Latent HIV-1 reactivation in transgenic mice requires cell cycle -dependent demethylation of CREB/ATF sites in the LTR
    J Tanaka
    Center for Experimental Medicine and the Department of Cancer Research, Institute of Medical Science, University of Tokyo, Japan
    AIDS 17:167-75. 2003
    ..In this report, we analysed further the reactivation mechanism of the latent HIV-1 using this transgenic mouse model...
  40. doi request reprint Increased fat:carbohydrate oxidation ratio in Il1ra (-/-) mice on a high-fat diet is associated with increased sympathetic tone
    D Chida
    Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Diabetologia 51:1698-706. 2008
    ..The present study was designed to analyse the mechanisms leading to this lean phenotype...
  41. ncbi request reprint Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes
    Y Tagawa
    Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Japan
    J Immunol 159:1418-28. 1997
    ..These observations suggest that IFN-gamma plays a central role in Con A-hepatitis by activating Fas-induced apoptosis of liver cells...
  42. ncbi request reprint A novel transcriptional regulatory factor that binds to the polyoma virus enhancer in a developmental stage-specific manner
    T Hirano
    Institute of Medical Science, University of Tokyo, Japan
    Biochimie 72:327-36. 1990
    ..These observations suggest that BF-H regulates the expression of genes in a developmental stage-specific manner in early embryos of the mouse...
  43. ncbi request reprint Suppression of oxidative stress after transient focal ischemia in interleukin-1 knock out mice
    H Ohtaki
    Department of Anatomy, Showa University School of Medicine, Tokyo, Japan
    Acta Neurochir Suppl 86:191-4. 2003
    ..These results strongly suggest that IL-1 is participated in generating reactive oxygen spices and it aggravates and induces the ischemic neuronal cell death.(183 words)...
  44. ncbi request reprint Generation of polymeric immunoglobulin receptor-deficient mouse with marked reduction of secretory IgA
    S Shimada
    Yakult Central Institute for Microbiological Research, Tokyo, Japan
    J Immunol 163:5367-73. 1999
    ..These results demonstrate that dIgA is mainly transported by pIgR on the epithelial cells of intestine and hepatocytes, but a small quantity of IgA may be secreted via other pathways...
  45. ncbi request reprint IL-1beta, but not IL-1alpha, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses
    Aya Nambu
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai, Tokyo 108 8639, Japan
    Int Immunol 18:701-12. 2006
    ..In addition, CD4+ T cell-derived IL-1 plays an important role in the activation of DCs during the elicitation phase, resulting in the production of TNF, that activate allergen-specific T cells...
  46. ncbi request reprint Involvement of tumor necrosis factor-alpha in the development of T cell-dependent aortitis in interleukin-1 receptor antagonist-deficient mice
    Taizo Matsuki
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai 4 6 1, Tokyo 108 8639, Japan
    Circulation 112:1323-31. 2005
    ..These mice also frequently develop aortitis at the root of the aorta, but the mechanism underlying the development of this disease has not been completely elucidated...
  47. ncbi request reprint Role of interferon-gamma in inflammatory responses in murine respiratory infection with Legionella pneumophila
    Yoko Shinozawa
    Second Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
    J Med Microbiol 51:225-30. 2002
    ..The findings suggest that retardation of host immune responses, including inflammatory cytokine production caused by deficiency of IFN-gamma, might allow the bacteria to grow and cause fulminant pneumonia...
  48. ncbi request reprint Immunogenicity of Peptide-25 of Ag85B in Th1 development: role of IFN-gamma
    Ai Kariyone
    Division of Immunology, Department of Microbiology and Immunology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 15:1183-94. 2003
    ....
  49. ncbi request reprint Protective roles of mast cells and mast cell-derived TNF in murine malaria
    Takahisa Furuta
    Department of Microbiology and Immunology, Division of Infectious Genetics, University of Tokyo, Japan
    J Immunol 177:3294-302. 2006
    ..These findings propose a novel mechanism that mast cells and mast cell-derived TNF play protective roles in malaria...
  50. doi request reprint Age-dependent regulation of depression-like behaviors through modulation of adrenergic receptor α₁A subtype expression revealed by the analysis of interleukin-1 receptor antagonist knockout mice
    C Wakabayashi
    Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Neuroscience 192:475-84. 2011
    ....
  51. pmc Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice
    N Uetani
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    EMBO J 19:2775-85. 2000
    ..To our knowledge, this is the first report of a specific PTP involved in the regulation of synaptic plasticity or in the processes regulating learning and memory...
  52. ncbi request reprint IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    Yutaka Komiyama
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Immunol 177:566-73. 2006
    ..These observations indicate that IL-17 rather than IFN-gamma plays a crucial role in the development of EAE...
  53. doi request reprint Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells
    Noriyuki Fujikado
    Center for Experimental Medicine, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Med 14:176-80. 2008
    ..These observations indicate that Dcir is a negative regulator of DC expansion and has a crucial role in maintaining the homeostasis of the immune system...
  54. doi request reprint Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II collagen antibody-induced arthritis
    Akinori Okumura
    National Institute of Infectious Diseases, Tokyo, Japan
    Arthritis Rheum 58:413-21. 2008
    ..To define the role of LECT2 in inflammatory arthritides, we investigated the development of collagen antibody-induced arthritis (CAIA) in LECT2-deficient (LECT2(-/-)) mice...
  55. ncbi request reprint Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 171:6173-7. 2003
    ..Thus, these observations suggest that IL-17 plays a crucial role in the development of CIA by activating autoantigen-specific cellular and humoral immune responses...
  56. ncbi request reprint Anti-type II collagen antibody accelerates arthritis via CXCR2-expressing cells in IL-1 receptor antagonist-deficient mice
    Takashi Kagari
    Biological Research Laboratories, Daiichi Sankyo Co Ltd, Tokyo, Japan
    Eur J Immunol 37:2753-63. 2007
    ....
  57. ncbi request reprint Role of Crk-associated substrate lymphocyte type in the pathophysiology of rheumatoid arthritis in tax transgenic mice and in humans
    Rikako Miyake-Nishijima
    Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Arthritis Rheum 48:1890-900. 2003
    ..To investigate the role of Crk-associated substrate lymphocyte type (Cas-L), a downstream signaling molecule of beta1 integrins, in the pathophysiology of rheumatoid arthritis (RA)...
  58. ncbi request reprint Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Immunity 17:375-87. 2002
    ..Our findings indicate that IL-17 plays an important role in activating T cells in allergen-specific T cell-mediated immune responses...
  59. ncbi request reprint IL-1-induced tumor necrosis factor-alpha elicits inflammatory cell infiltration in the skin by inducing IFN-gamma-inducible protein 10 in the elicitation phase of the contact hypersensitivity response
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 15:251-60. 2003
    ..Reduced CHS in TNF-alpha(-/-) mice was reversed by IP-10 injection during the elicitation phase. Thus, it was shown that the roles for IL-1 and TNF-alpha are different, although both cytokines are crucial for the development of CHS...
  60. ncbi request reprint Essential role of MD-2 in LPS responsiveness and TLR4 distribution
    Yoshinori Nagai
    Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Immunol 3:667-72. 2002
    ..Thus, MD-2 is essential for correct intracellular distribution and LPS-recognition of TLR4...
  61. ncbi request reprint Involvement of tumor necrosis factor alpha, rather than interleukin-1alpha/beta or nitric oxides in the heme oxygenase-1 gene expression by lipopolysaccharide in the mouse liver
    Takiko Oguro
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, 142 8555, Tokyo, Japan
    FEBS Lett 516:63-6. 2002
    ..All of these findings indicate that TNFalpha is a major candidate to trigger HO-1 induction in response to LPS stimulation, and that its message is likely transduced through JNK and p38 pathways...
  62. ncbi request reprint Peripheral TNFalpha, but not peripheral IL-1, requires endogenous IL-1 or TNFalpha induction in the brain for the febrile response
    Dai Chida
    Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 364:765-70. 2007
    ....
  63. ncbi request reprint Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver
    Takashi Ashino
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Tokyo, Japan
    Eur J Pharmacol 558:199-207. 2007
    ....
  64. ncbi request reprint Systemic administration of IL-23 induces potent antitumor immunity primarily mediated through Th1-type response in association with the endogenously expressed IL-12
    Teruo Kaiga
    Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 461 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    J Immunol 178:7571-80. 2007
    ....
  65. doi request reprint Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses
    Harumichi Ishigame
    Center for Experimental Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Immunity 30:108-19. 2009
    ..These observations indicate that IL-17A and IL-17F have overlapping yet distinct roles in host immune and defense mechanisms...
  66. ncbi request reprint Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis
    Taizo Matsuki
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 18:399-407. 2006
    ..These observations suggest that the IL-1/IL-1Ra system is crucial for auto-antigen-specific T cell induction and contributes to the development of EAE...
  67. ncbi request reprint Interleukin-1-deficient mice exhibit high sensitivity to gut-derived sepsis caused by Pseudomonas aeruginosa
    Tetsuya Horino
    Department of Internal Medicine, Jikei University School of Medicine, Nishi Shimbashi, Minato ku, Tokyo, Japan
    Cytokine 30:339-46. 2005
    ..We evaluated the role of endogenous IL-1 in gut-derived sepsis caused by Pseudomonas aeruginosa, by comparing IL-1-deficient mice and wild-type (WT) mice...
  68. doi request reprint Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A
    Naoko Okiyama
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 60:2505-12. 2009
    ..To explore new molecular targets in the treatment of polymyositis (PM) by examining a recently established murine model of PM, C protein-induced myositis (CIM), for involvement of an interleukin-6 (IL-6)/IL-17A pathway...
  69. doi request reprint TNF, but not IL-6 and IL-17, is crucial for the development of T cell-independent psoriasis-like dermatitis in Il1rn-/- mice
    Akiko Nakajima
    Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Immunol 185:1887-93. 2010
    ..These observations suggest that excess IL-1 signaling directly activates keratinocytes to produce TNF and chemokines, resulting in the development of psoriasis-like skin lesions without the involvement of autoimmunity in Il1rn(-/-) mice...
  70. pmc Growth retardation and early death of beta-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells
    M Asano
    Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Minato ku, Japan
    EMBO J 16:1850-7. 1997
    ..These observations suggest that GalT plays critical roles in the regulation of proliferation and differentiation of epithelial cells after birth, although this enzyme is dispensable during embryonic development...
  71. doi request reprint Interleukin-1 deficiency in combination with macrophage depletion increases susceptibility to Pseudomonas aeruginosa bacteremia
    Tetsuya Horino
    Department of Infectious Disease and Infection Control, The Jikei University School of Medicine, 3 19 18 Nishi Shimbashi, Minato ku, Tokyo, Japan
    Microbiol Immunol 53:502-11. 2009
    ..Thus, IL-1 deficiency becomes disadvantageous during P. aeruginosa bacteremia when it is accompanied by immunosuppression, particularly when macrophage functions are seriously impaired...
  72. pmc Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour
    Sachiko Taniguchi
    Division of Oncology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    EMBO J 28:3717-29. 2009
    ..These data argue that Tyr 1325 phosphorylation regulates NMDA receptor channel properties and the NMDA receptor-mediated downstream signalling to modulate depression-related behaviour...
  73. doi request reprint Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans
    Shinobu Saijo
    Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku Tokyo 108 8639, Japan
    Immunity 32:681-91. 2010
    ..Because IL-17A-deficient mice were highly susceptible to systemic candida infection, this study suggests that Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation...
  74. ncbi request reprint Role of interferon-gamma in the development of murine bronchus-associated lymphoid tissues induced by silica in vivo
    Masashi Desaki
    Department of Respiratory Medicine, Graduate School of Medicine, Instutute of Medical Science, University of Tokyo, Tokyo, Japan
    Toxicol Appl Pharmacol 185:1-7. 2002
    ..These results suggest that IFN-gamma has an inhibitory effect on the development of BALT and may be involved in small airway disease in silicotic lung...
  75. ncbi request reprint A new murine model to define the critical pathologic and therapeutic mediators of polymyositis
    Takahiko Sugihara
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 56:1304-14. 2007
    ..To establish a new murine model of polymyositis (PM) for the understanding of its pathologic mechanisms and the development of new treatment strategies...
  76. doi request reprint Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury
    Takashi Shichita
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    Nat Med 15:946-50. 2009
    ..We propose that T lymphocytes, including gammadeltaT lymphocytes, could be a therapeutic target for mitigating the inflammatory events that amplify the initial damage in cerebral ischemia...
  77. ncbi request reprint Pathological changes of renal epithelial cells in mice transgenic for the TT virus ORF1 gene
    Hiroshi Yokoyama
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Gen Virol 83:141-50. 2002
    ..These observations suggest that TTV affects renal epithelial cells as part of the naturally occurring infection...
  78. ncbi request reprint IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 15:483-90. 2003
    ..These observations indicate that IL-1 plays important roles in the development of AHR...
  79. ncbi request reprint Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans
    Shinobu Saijo
    Center for Experimental Medicine, The Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Immunol 8:39-46. 2007
    ..Thus, dectin-1 is required for immune responses to some fungal infections, as protective immunity to pneumocystis, but not to candida, required dectin-1 for the production of antifungal reactive oxygen species...
  80. doi request reprint The mechanism of LPS-induced HIV type I activation in transgenic mouse macrophages
    Motohiko Kadoki
    Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato ku, Tokyo, Japan
    Int Immunol 22:469-78. 2010
    ....
  81. ncbi request reprint Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages
    Masato Murakami
    Division of Genetics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    Blood 108:1849-56. 2006
    ....
  82. ncbi request reprint Involvement of corticotropin-releasing hormone- and interleukin (IL)-6-dependent proopiomelanocortin induction in the anterior pituitary during hypothalamic-pituitary-adrenal axis activation by IL-1alpha
    Dai Chida
    Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Japan
    Endocrinology 146:5496-502. 2005
    ..Our results suggest a role for IL-1alpha/beta in the induction of POMC in the AP through the induction of two independent pathways, CRH and IL-6...
  83. doi request reprint Kid-mediated chromosome compaction ensures proper nuclear envelope formation
    Miho Ohsugi
    Division of Oncology, Department of Cancer Biology, The University of Tokyo, Minato ku, Tokyo, 108 8639, Japan
    Cell 132:771-82. 2008
    ..This protection is especially important during the very early stages of development, when the embryonic cells are rich in ooplasm...
  84. doi request reprint Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation
    Akane Inoue
    Division of Genetics and Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Sci Signal 2:ra7. 2009
    ..These observations indicate that Dok-7 positively regulates neuromuscular synaptogenesis by controlling MuSK activity, its distribution, and its responsiveness to neural agrin...
  85. ncbi request reprint Interleukin-1beta abrogates long-term depression of hippocampal CA1 synaptic transmission
    Yuji Ikegaya
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    Synapse 47:54-7. 2003
    ..These results suggest that IL-1beta-induced, persistent depression of synaptic efficacy is required for GABAergic activation and shares, at least in part, a common cellular mechanism for LTD...
  86. ncbi request reprint Polylactosamine synthesis and branch formation of N-glycans in beta1,4-galactosyltransferase-1-deficient mice
    Norihiro Kotani
    Division of Biochemistry, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Arch Biochem Biophys 426:258-65. 2004
    ..These results suggest that beta4GalT-1 expressed in erythroid cells may regulate a constant branch formation of N-glycans and plays a predominant role in beta1,4-galactosylation of core 2 O-glycan...
  87. ncbi request reprint Suppression of oxidative neuronal damage after transient middle cerebral artery occlusion in mice lacking interleukin-1
    Hirokazu Ohtaki
    Department of Anatomy, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, 142 8555, Tokyo, Japan
    Neurosci Res 45:313-24. 2003
    ..These results indicate that IL-1 is up-regulated and may play a role in neurodegeneration by peroxynitrite production during ischemia...
  88. ncbi request reprint Combined interleukin-6 and interleukin-1 deficiency causes obesity in young mice
    Dai Chida
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Toyko 108 8639, Japan
    Diabetes 55:971-7. 2006
    ..These results indicate that IL-1 and IL-6 are both involved in the regulation of body fat in a redundant manner in young mice...
  89. doi request reprint Functional hypothalamic amenorrhea due to increased CRH tone in melanocortin receptor 2-deficient mice
    Takashi Matsuwaki
    Department of Veterinary Physiology, The University of Tokyo, Tokyo, Japan
    Endocrinology 151:5489-96. 2010
    ..Our findings show that high levels of hypothalamic CRH disturb estrous cyclicity in the female animals and that the MC2R(-/-) female is a unique animal model of functional hypothalamic amenorrhea...
  90. ncbi request reprint Diurnal variation of heart rate, locomotor activity, and body temperature in interleukin-1 alpha/beta doubly deficient mice
    Masashi Furuzawa
    Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Exp Anim 51:49-56. 2002
    ..These results suggest that IL-1 may play important physiological and pathophysiological roles on biobehavioral activities...
  91. ncbi request reprint Protection against influenza virus infection in polymeric Ig receptor knockout mice immunized intranasally with adjuvant-combined vaccines
    Yasuko Asahi
    Department of Pathology, National Institute of Infectious Diseases, Yakult Central Institute for Microbiological Research, and Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 168:2930-8. 2002
    ....
  92. ncbi request reprint Interleukin (IL)-6, but not IL-1, induction in the brain downstream of cyclooxygenase-2 is essential for the induction of febrile response against peripheral IL-1alpha
    Kyoko Kagiwada
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Endocrinology 145:5044-8. 2004
    ..These observations suggest a mechanism of IL-1-induced febrile response in which IL-1 in the blood activates Cox-2, with the resulting prostaglandin E(2) inducing IL-6 in the brain, leading to the development of fever...
  93. pmc Nuclear import of the preintegration complex is blocked upon infection by human immunodeficiency virus type 1 in mouse cells
    Naomi Tsurutani
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Tokyo 108 8639, Japan
    J Virol 81:677-88. 2007
    ..On the other hand, GFP-Vpr localized exclusively to the nuclei of both mouse and human cells. These observations suggest that, due to the dysfunction of integrase, the nuclear localization of PIC is suppressed in mouse cells...
  94. ncbi request reprint Induction of IgG2a class switching in B cells by IL-27
    Takayuki Yoshimoto
    Intractable Immune System Disease Research Center, Tokyo Medical University, Tokyo, Japan
    J Immunol 173:2479-85. 2004
    ..Thus, IL-27 may be a novel attractive candidate as a therapeutic agent against diseases such as allergic disorders by not only regulating Th1 differentiation but also directly acting on B cells and inducing IgG2a class switching...
  95. pmc Inhibition of B16 melanoma experimental metastasis by interferon-gamma through direct inhibition of cell proliferation and activation of antitumour host mechanisms
    Shigeru Kakuta
    Center for Experimental Medicine, Insitute of Medical Science, University of Tokyo, Tokyo, Japan
    Immunology 105:92-100. 2002
    ..These observations suggest that IFN-gamma prevents B16 melanoma experimental metastasis by directly inhibiting the cell growth, although antitumour host functions may also be involved in a later phase...
  96. doi request reprint IL-17A is produced by Th17, gammadelta T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance
    Silke M Schulz
    Institute of Immunology, College of Veterinary Medicine, University of Leipzig, An den Tierkliniken 11, 04103 Leipzig, Germany
    Int Immunol 20:1129-38. 2008
    ..Enteritidis infection. Thus, IL-17A complements the IL-12/IFN-gamma axis which is essential for protective immunity against salmonellosis in mice and men...
  97. ncbi request reprint Role of IFN-gamma and tumor necrosis factor-alpha in herpes simplex virus type 1 infection
    Masato Minami
    Department of Microbiology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    J Interferon Cytokine Res 22:671-6. 2002
    ..These results suggest that IFN-gamma and TNF-alpha play an important role in acute infection and reactivation from latency...
  98. ncbi request reprint Panax ginseng induces production of proinflammatory cytokines via toll-like receptor
    Taka Aki Nakaya
    Department of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Interferon Cytokine Res 24:93-100. 2004
    ..These results suggest that GRE contains a non-LPS agent that enhances innate immunity through production of proinflammatory cytokines via TLR-4...
  99. pmc Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction
    Leo A B Joosten
    Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Am J Pathol 165:959-67. 2004
    ..These findings implicate that IL-18, in contrast to TNF, contributes through separate pathways to joint inflammation and cartilage destruction...
  100. ncbi request reprint IFN-gamma and TNF-alpha are involved in urushiol-induced contact hypersensitivity in mice
    Toshiteru Wakabayashi
    Department of Bacteriology, Hirosaki University School of Medicine, Hirosaki, Japan
    Immunol Cell Biol 83:18-24. 2005
    ..These results suggest that IFN-gamma, TNF-alpha, and possibly IP-10, play a critical role in CHS induced by urushiol, depending on both CD4+ T cells and CD8+ T cells...
  101. ncbi request reprint Compensatory response of IL-1 gene knockout mice after pulmonary infection with Klebsiella pneumoniae
    Masaaki Tanabe
    Department of Microbiology, Omori Hospital, Toho University School of Medicine, 5 21 16 Omori nishi, Ota ku Tokyo, Japan
    J Med Microbiol 54:7-13. 2005
    ..The data suggest that compensatory production of TNF-alpha in IL-1 KO mice contributes to the host defence against K. pneumoniae infection...