Chie Ishikawa

Summary

Affiliation: University of the Ryukyus
Country: Japan

Publications

  1. doi request reprint Epstein-Barr virus latent membrane protein 1 induces CD69 expression through activation of nuclear factor-κB
    Chie Ishikawa
    Transdisciplinary Research Organization for Subtropics and Island Studies, Nishihara, Okinawa 903 0213, Japan
    Int J Oncol 42:1786-92. 2013
  2. doi request reprint CD69 overexpression by human T-cell leukemia virus type 1 Tax transactivation
    Chie Ishikawa
    Department of Microbiology and Oncology, University of the Ryukyus, Okinawa, Japan
    Biochim Biophys Acta 1833:1542-52. 2013
  3. doi request reprint Honokiol induces cell cycle arrest and apoptosis via inhibition of survival signals in adult T-cell leukemia
    Chie Ishikawa
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Biochim Biophys Acta 1820:879-87. 2012
  4. pmc NF-kappaB activation by Helicobacter pylori requires Akt-mediated phosphorylation of p65
    Eriko Takeshima
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    BMC Microbiol 9:36. 2009
  5. doi request reprint Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Int J Cancer 124:2607-15. 2009
  6. pmc Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells
    Reika Takamatsu
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    BMC Microbiol 10:1. 2010
  7. ncbi request reprint Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway
    Chie Ishikawa
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of Ryukyus, Nishihara, Japan
    Br J Haematol 136:424-32. 2007
  8. ncbi request reprint A modified version of galectin-9 suppresses cell growth and induces apoptosis of human T-cell leukemia virus type I-infected T-cell lines
    Taeko Okudaira
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Int J Cancer 120:2251-61. 2007
  9. ncbi request reprint A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells
    Shoko Makishi
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Br J Haematol 142:583-94. 2008
  10. pmc Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol
    Yoshiaki Machijima
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Retrovirology 6:7. 2009

Collaborators

Detail Information

Publications39

  1. doi request reprint Epstein-Barr virus latent membrane protein 1 induces CD69 expression through activation of nuclear factor-κB
    Chie Ishikawa
    Transdisciplinary Research Organization for Subtropics and Island Studies, Nishihara, Okinawa 903 0213, Japan
    Int J Oncol 42:1786-92. 2013
    ..This is the first report of the regulation of CD69 expression by LMP-1, and this novel finding may, thus, represent an important link between the EBV oncoprotein LMP-1 and its critical role in the development of EBV-associated diseases...
  2. doi request reprint CD69 overexpression by human T-cell leukemia virus type 1 Tax transactivation
    Chie Ishikawa
    Department of Microbiology and Oncology, University of the Ryukyus, Okinawa, Japan
    Biochim Biophys Acta 1833:1542-52. 2013
    ..We conclude that CD69 is a Tax-regulated gene, and its regulation by Tax may play a role in cellular activation and HTLV-1-induced disease pathogenesis...
  3. doi request reprint Honokiol induces cell cycle arrest and apoptosis via inhibition of survival signals in adult T-cell leukemia
    Chie Ishikawa
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Biochim Biophys Acta 1820:879-87. 2012
    ..Honokiol, a naturally occurring biphenyl, possesses anti-neoplastic properties. We investigated activities of honokiol against adult T-cell leukemia (ATL) associated with human T-cell leukemia virus type 1 (HTLV-1)...
  4. pmc NF-kappaB activation by Helicobacter pylori requires Akt-mediated phosphorylation of p65
    Eriko Takeshima
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    BMC Microbiol 9:36. 2009
    ..We examined whether H. pylori activates Akt in gastric epithelial cells, the role of cag PAI in this process and the role of Akt in regulating H. pylori-induced NF-kappaB activation...
  5. doi request reprint Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity
    Mariko Tomita
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Int J Cancer 124:2607-15. 2009
    ..These findings highlight the critical role of Aurora A in HTLV-1-infected T cells, making this molecule a potentially suitable target for future therapies for ATL...
  6. pmc Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells
    Reika Takamatsu
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    BMC Microbiol 10:1. 2010
    ..pneumophila to infect and stimulate the production of interleukin-8 (IL-8) in T cells. The objective of this study was to assess whether L. pneumophila interferes with the immune system by interacting and infecting T cells...
  7. ncbi request reprint Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway
    Chie Ishikawa
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of Ryukyus, Nishihara, Japan
    Br J Haematol 136:424-32. 2007
    ..These findings suggest that incadronate could be potentially useful for the treatment of ATL...
  8. ncbi request reprint A modified version of galectin-9 suppresses cell growth and induces apoptosis of human T-cell leukemia virus type I-infected T-cell lines
    Taeko Okudaira
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Int J Cancer 120:2251-61. 2007
    ..Our results suggest that hG9NC(null) could be a suitable agent for the management of ATL...
  9. ncbi request reprint A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells
    Shoko Makishi
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Br J Haematol 142:583-94. 2008
    ..hG9NC(null) inhibited the expression of JunD, resulting in the suppression of AP-1. Our results suggest that hG9NC(null) is a potentially suitable agent for the management of BL and HL...
  10. pmc Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol
    Yoshiaki Machijima
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Retrovirology 6:7. 2009
    ..The aim of this study was to determine the potential anti-ATLL effects of I3C both in vitro and in vivo...
  11. pmc Helicobacter pylori-induced interleukin-12 p40 expression
    Eriko Takeshima
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Infect Immun 77:1337-48. 2009
    ..Hsp90 is also a crucial regulator of H. pylori-induced IL-12 p40 expression. In addition to the cag PAI, VacA might be relevant in the induction of IL-12 expression and a Th1-polarized response only in T cells...
  12. doi request reprint Anti-adult T-cell leukemia effects of a novel synthetic retinoid, Am80 (Tamibarotene)
    Tetsuro Nakazato
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Cancer Sci 99:2286-94. 2008
    ..These findings demonstrate that Am80 is a potential inhibitor of NF-kappaB and AP-1, and is a potentially useful therapeutic agent against ATL...
  13. doi request reprint Inhibition of Akt/GSK3beta signalling pathway by Legionella pneumophila is involved in induction of T-cell apoptosis
    Reika Takamatsu
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Biochem J 427:57-67. 2010
    ..In conclusion, L. pneumophila induces mitochondria-mediated T-cell apoptosis through inhibition of the Akt/GSK3beta signalling pathway...
  14. doi request reprint Anticancer effects of marine carotenoids, fucoxanthin and its deacetylated product, fucoxanthinol, on osteosarcoma
    Takayoshi Rokkaku
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0215, Japan
    Int J Oncol 43:1176-86. 2013
    ..Our findings provide a rationale for clinical evaluation of these novel agents in osteosarcoma...
  15. pmc Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules
    Hiromitsu Teruya
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Retrovirology 5:86. 2008
    ..However, little is known about induction of these genes by HTLV-I infection in lung epithelial cells...
  16. ncbi request reprint Protein phosphatase 2A as a potential target for treatment of adult T cell leukemia
    Naoki Mori
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Curr Cancer Drug Targets 13:829-42. 2013
    ..These results suggest that PP2A is a potentially useful target in the treatment of ATL...
  17. ncbi request reprint Inhibition of heat shock protein-90 modulates multiple functions required for survival of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells
    Hirochika Kawakami
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan
    Int J Cancer 120:1811-20. 2007
    ..Collectively, our results indicate that 17-AAG suppresses ATL cell survival through, at least in part, destabilization of several client proteins and suggest that 17-AAG is a potentially useful chemotherapeutic agent for ATL...
  18. doi request reprint Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol
    Chie Ishikawa
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Int J Cancer 123:2702-12. 2008
    ..Our preclinical data suggest that fucoxanthin and fucoxanthinol could be potentially useful therapeutic agents for patients with ATL...
  19. pmc Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells
    Hiromitsu Teruya
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    BMC Microbiol 7:102. 2007
    ..We investigated the effect of L. pneumophila on the expression of interleukin-8 (IL-8) in human A549 alveolar and NCI-H292 tracheal epithelial cell lines...
  20. doi request reprint Overexpression of caveolin-1 in adult T-cell leukemia
    Shigeki Sawada
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Blood 115:2220-30. 2010
    ..Thus, we describe a new function for Tax, repression of TGF-beta signaling through caveolin-1 expression, which may play a critical role in ATL leukemogenesis...
  21. doi request reprint Fucoxanthin and its deacetylated product, fucoxanthinol, induce apoptosis of primary effusion lymphomas
    Kei Yamamoto
    Department of Microbiology and Oncology, University of the Ryukyus, Nishihara, Okinawa, Japan
    Cancer Lett 300:225-34. 2011
    ..In animal studies, treatment with FX reduced the growth of PEL-cell tumors. The results provide the rationale for future clinical use of FX and FXOH for the treatment of PEL...
  22. doi request reprint Anti-neoplastic effects of fucoxanthin and its deacetylated product, fucoxanthinol, on Burkitt's and Hodgkin's lymphoma cells
    Senji Tafuku
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0215, Japan
    Oncol Rep 28:1512-8. 2012
    ..The results indicated that FX and FXOH are potentially useful therapeutic agents in B-cell malignancies characterized by aberrant regulation of NF-κB...
  23. doi request reprint Helicobacter pylori VacA activates NF-kappaB in T cells via the classical but not alternative pathway
    Eriko Takeshima
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    Helicobacter 14:271-9. 2009
    ..VacA has also immunosuppressive effects, inhibiting interleukin (IL)-2 secretion by interference with the T cell receptor/IL-2 signaling pathway. This study investigated the effect of VacA on gene expression of T cells...
  24. pmc Hippuristanol reduces the viability of primary effusion lymphoma cells both in vitro and in vivo
    Chie Ishikawa
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Mar Drugs 11:3410-24. 2013
    ..The results of the in vitro and in vivo experiments underline the potential usefulness of hippuristanol in the treatment of PEL. ..
  25. pmc Induction of CD69 expression by cagPAI-positive Helicobacter pylori infection
    Naoki Mori
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0215, Japan
    World J Gastroenterol 17:3691-9. 2011
    ..To investigate and elucidate the molecular mechanism that regulates inducible expression of CD69 by Helicobacter pylori (H. pylori) infection...
  26. ncbi request reprint NIK-333 inhibits growth of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells in association with blockade of nuclear factor-kappaB signal pathway
    Taeko Okudaira
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Mol Cancer Ther 5:704-12. 2006
    ..c. in severe combined immunodeficient mice. Our results indicate that NIK-333 is a potentially useful therapeutic agent for patients with ATL...
  27. pmc Antitumor activity and macrophage nitric oxide producing action of medicinal herb, Crassocephalum crepidioides
    Koh Tomimori
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0215, Japan
    BMC Complement Altern Med 12:78. 2012
    ..The aim of this study was to determine the in vitro and in vivo antitumor activities of C. crepidioides on murine Sarcoma 180 (S-180) and related molecular mechanisms...
  28. doi request reprint Anti-adult T-cell leukemia effects of Bidens pilosa
    Shinji Nakama
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Int J Oncol 38:1163-73. 2011
    ..In animals harboring tumors of HTLV-1-infected T-cell origin, treatment with B. pilosa extracts suppressed tumor growth. Our results suggest that B. pilosa is a potentially useful medicinal plant for treatment of ATL...
  29. doi request reprint Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling
    Sawako Nakachi
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Biochim Biophys Acta 1813:731-41. 2011
    ..These results suggest that the induction of MMP-7 by Tax is regulated by JunD and that MMP-7 could facilitate visceral invasion in ATL. This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
  30. doi request reprint Phosphorylated c-Jun and Fra-1 induce matrix metalloproteinase-1 and thereby regulate invasion activity of 143B osteosarcoma cells
    Ryuichiro Kimura
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Biochim Biophys Acta 1813:1543-53. 2011
    ..These data suggest that MMP-1 plays a central role in osteosarcoma invasion. Accordingly, MMP-1 might be a biomarker and therapeutic target for invasive osteosarcomas and pulmonary metastases...
  31. doi request reprint Interleukin-1 alpha produced by human T-cell leukaemia virus type I-infected T cells induces intercellular adhesion molecule-1 expression on lung epithelial cells
    Yuko Nakayama
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan
    J Med Microbiol 60:1750-61. 2011
    ..These results suggest that IL-1α produced by HTLV-I-infected Tax(+) T cells is crucial for ICAM-1 expression in lung epithelial cells and subsequent adhesion of lymphocytes in HTLV-I-related pulmonary diseases...
  32. pmc Helicobacter pylori induces CCL20 expression
    Koh Tomimori
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Infect Immun 75:5223-32. 2007
    ..pylori-induced CCL20 expression, presumably contributing to the immune response in H. pylori...
  33. doi request reprint Anti-tumor activity of fucoidan is mediated by nitric oxide released from macrophages
    Kaori Takeda
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Int J Oncol 40:251-60. 2012
    ....
  34. doi request reprint Effects of AZD1152, a selective Aurora B kinase inhibitor, on Burkitt's and Hodgkin's lymphomas
    Naoki Mori
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Biochem Pharmacol 81:1106-15. 2011
    ..AZD1152 had anti-tumour effects in this murine xenograft model. There preclinical data suggest that the inhibition of Aurora B kinase is a potentially useful therapeutic strategy in BL and HL...
  35. doi request reprint Activation of AID by human T-cell leukemia virus Tax oncoprotein and the possible role of its constitutive expression in ATL genesis
    Chie Ishikawa
    Department of Microbiology and Oncology, University of the Ryukyus, Nishihara, Okinawa, Japan
    Carcinogenesis 32:110-9. 2011
    ....
  36. doi request reprint Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia
    Tomoyuki Tsumuraya
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Biochem Pharmacol 81:713-22. 2011
    ..These preclinical data suggest that hippuristanol could be a potentially useful therapeutic agent for patients with ATL...
  37. pmc Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection
    Naoki Mori
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0215, Japan
    World J Gastroenterol 18:2225-30. 2012
    ..To evaluate the effects of fucoidan, a complex sulfated polysaccharide extract from marine seaweed, on hepatitis C virus (HCV) RNA load both in vitro and in vivo...
  38. pmc Efficacy of Bidens pilosa Extract against Herpes Simplex Virus Infection In Vitro and In Vivo
    Shinji Nakama
    Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Evid Based Complement Alternat Med 2012:413453. 2012
    ..Our results indicate that B. pilosa has anti-HSV activity and is thus a potentially useful medical plant for treatment of HSV infection...
  39. ncbi request reprint Transactivation of the ICAM-1 gene by CD30 in Hodgkin's lymphoma
    Jun Nosuke Uchihara
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Int J Cancer 118:1098-107. 2006
    ....