Hiroki Ishiguro

Summary

Affiliation: University of Tsukuba
Country: Japan

Publications

  1. ncbi request reprint Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population
    Shinya Iwasaki
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Psychiatr Genet 17:215-20. 2007
  2. ncbi request reprint PICK1 is not a susceptibility gene for schizophrenia in a Japanese population: association study in a large case-control population
    H Ishiguro
    Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
    Neurosci Res 58:145-8. 2007
  3. ncbi request reprint Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans
    H Ishiguro
    Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Pharmacogenomics J 7:380-5. 2007
  4. ncbi request reprint Variation in a bicarbonate co-transporter gene family member SLC4A7 is associated with propensity to addictions: a study using fine-mapping and three samples
    Hiroki Ishiguro
    Molecular Neurobiology Branch, NIH IRP, NIDA, DHHS, Baltimore, MD, USA
    Addiction 102:1320-5. 2007
  5. ncbi request reprint RGS4 is not a susceptibility gene for schizophrenia in Japanese: association study in a large case-control population
    H Ishiguro
    Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305 8575, Japan
    Schizophr Res 89:161-4. 2007
  6. doi request reprint Association of PTPRB gene polymorphism with drug addiction
    Hiroki Ishiguro
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1167-72. 2008
  7. pmc Supportive evidence for reduced expression of GNB1L in schizophrenia
    Hiroki Ishiguro
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Schizophr Bull 36:756-65. 2010
  8. doi request reprint Brain cannabinoid CB2 receptor in schizophrenia
    Hiroki Ishiguro
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Biol Psychiatry 67:974-82. 2010
  9. doi request reprint Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia
    Minori Koga
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Hum Mol Genet 18:2483-94. 2009
  10. ncbi request reprint A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia
    Tsuyuka Ohtsuki
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    Schizophr Res 101:9-16. 2008

Detail Information

Publications35

  1. ncbi request reprint Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population
    Shinya Iwasaki
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Psychiatr Genet 17:215-20. 2007
    ..Owing to the importance of endocannabinoid system in addiction, the Pro129Thr polymorphism in the FAAH gene has reportedly been associated with substance abuse and dependence in a Caucasian population...
  2. ncbi request reprint PICK1 is not a susceptibility gene for schizophrenia in a Japanese population: association study in a large case-control population
    H Ishiguro
    Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
    Neurosci Res 58:145-8. 2007
    ..We conclude that the common haplotypes and polymorphisms of the PICK1 gene identified thus far are unlikely to contribute to genetic susceptibility to schizophrenia in the Japanese population...
  3. ncbi request reprint Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans
    H Ishiguro
    Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Pharmacogenomics J 7:380-5. 2007
    ..007; odds ratio 1.25, 95% CI, (1.06-1.47)). CB2 under such environment is associated with the physiologic effects of alcohol and CB2 antagonists may have potential as therapies for alcoholism...
  4. ncbi request reprint Variation in a bicarbonate co-transporter gene family member SLC4A7 is associated with propensity to addictions: a study using fine-mapping and three samples
    Hiroki Ishiguro
    Molecular Neurobiology Branch, NIH IRP, NIDA, DHHS, Baltimore, MD, USA
    Addiction 102:1320-5. 2007
    ..We have focused attention on 'reproducible substance abuse vulnerability' (rSA) genomic regions, where linkage and association studies performed in several population provide evidence for such variations...
  5. ncbi request reprint RGS4 is not a susceptibility gene for schizophrenia in Japanese: association study in a large case-control population
    H Ishiguro
    Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305 8575, Japan
    Schizophr Res 89:161-4. 2007
    ..We conclude that the common haplotypes and SNPs of the RGS4 gene identified thus far are unlikely to contribute to the genetic susceptibility to schizophrenia in the Japanese population...
  6. doi request reprint Association of PTPRB gene polymorphism with drug addiction
    Hiroki Ishiguro
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1167-72. 2008
    ..Thus, PTPRB is an addiction-associated and drug-regulated gene whose variants may affect substance abuse vulnerability...
  7. pmc Supportive evidence for reduced expression of GNB1L in schizophrenia
    Hiroki Ishiguro
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Schizophr Bull 36:756-65. 2010
    ..In the present study, we screened for genes located in the 22q11DS region that are expressed at lower levels in postmortem prefrontal cortex of patients with schizophrenia than in those of controls...
  8. doi request reprint Brain cannabinoid CB2 receptor in schizophrenia
    Hiroki Ishiguro
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Biol Psychiatry 67:974-82. 2010
    ..Neural endocannabinoid function appears to be involved in schizophrenia. Two endocannabinoid receptors, CB1 and CB2, are found in the brain and elsewhere in the body. We investigated roles of CB2 in schizophrenia...
  9. doi request reprint Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia
    Minori Koga
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Hum Mol Genet 18:2483-94. 2009
    ..Psychotogenic drugs lowered Smarca2 expression while antipsychotic drugs increased it in the mouse brain. These findings support the existence of a role for BRM in the pathophysiology of schizophrenia...
  10. ncbi request reprint A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia
    Tsuyuka Ohtsuki
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    Schizophr Res 101:9-16. 2008
    ..The GRM7 gene is located on human chromosome 3p26, which has been suggested by linkage analysis to contain a susceptibility locus for schizophrenia...
  11. ncbi request reprint Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population
    Minori Koga
    Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Neurosci Lett 417:326-9. 2007
    ..79, respectively). We concluded that the missense mutation Asp123Glu of the FEZ1 gene is unlikely to play a substantial role in the genetic susceptibility to schizophrenia...
  12. ncbi request reprint Monoallelic and unequal allelic expression of the HTR2A gene in human brain and peripheral lymphocytes
    Yoshiko Fukuda
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Biol Psychiatry 60:1331-5. 2006
    ..Studies of expression of HTR2A messenger RNA (mRNA) and protein in postmortem brains suggest that the 102C allele might be less transcriptionally active than the T allele. However, equal expression of both alleles has also been reported...
  13. ncbi request reprint Replication study and meta-analysis of the genetic association of GRM3 gene polymorphisms with schizophrenia in a large Japanese case-control population
    Talal Albalushi
    Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:392-6. 2008
    ..Our data indicate that SNPs previously reported to be associated with schizophrenia do not contribute to genetic susceptibility to schizophrenia...
  14. ncbi request reprint Replication study of association between ADCYAP1 gene polymorphisms and schizophrenia
    Minori Koga
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Psychiatr Genet 20:123-5. 2010
    ..53-0.86). It is concluded that single-nucleotide polymorphisms, including Asp54Gly, of the ADCYAP1 gene are unlikely to play a sizeable role in the genetic susceptibility to schizophrenia...
  15. pmc Association of the HSPG2 gene with neuroleptic-induced tardive dyskinesia
    Aoi Syu
    Department of Medical Genetics and Department of Molecular Neurobiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Neuropsychopharmacology 35:1155-64. 2010
    ..These findings suggest that the HSPG2 gene is involved in neuroleptic-induced TD and higher expression of HSPG2, probably even after antipsychotic treatment, and may be associated with TD susceptibility...
  16. doi request reprint An association study between the dymeclin gene and schizophrenia in the Japanese population
    Saori Yazaki
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    J Hum Genet 55:631-4. 2010
    ..The present data support the involvement of Golgi function and vesicular transport in the presynapse in schizophrenia...
  17. doi request reprint Association of SNPs linked to increased expression of SLC1A1 with schizophrenia
    Yasue Horiuchi
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Am J Med Genet B Neuropsychiatr Genet 159:30-7. 2012
    ..003). Our findings suggest the involvement of SLC1A1 in the pathogenesis of schizophrenia...
  18. pmc Experimental evidence for the involvement of PDLIM5 in mood disorders in hetero knockout mice
    Yasue Horiuchi
    Department of Medical Genetics, Majors of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    PLoS ONE 8:e59320. 2013
    ..Acute and chronic methamphetamine (METH) administration may model mania and the evolution of mania into psychotic mania or schizophrenia-like behavioral changes, respectively...
  19. ncbi request reprint Cannabinoid CB2 receptors: immunohistochemical localization in rat brain
    Jian Ping Gong
    Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 20892, USA
    Brain Res 1071:10-23. 2006
    ..The multifocal expression of CB2 immunoreactivity in glial and neuronal patterns in a number of brain regions suggests reevaluation of the possible roles that CB2 receptors may play in the brain...
  20. pmc Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p
    Tadao Arinami
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki Ken, 305 8577, Japan
    Am J Hum Genet 77:937-44. 2005
    ....
  21. ncbi request reprint Possible association between a haplotype of the GABA-A receptor alpha 1 subunit gene (GABRA1) and mood disorders
    Yasue Horiuchi
    Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Biol Psychiatry 55:40-5. 2004
    ..The GABRA1 gene encodes one of the subunits of GABA-A receptor and is located on human chromosome 5q34-q35, which is a region reportedly linked to mood disorders. We examined the GABRA1 gene as a candidate for mood disorders...
  22. ncbi request reprint NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice
    Hiroki Ishiguro
    Molecular Neurobiology Branch, NIDA IRP, NIH, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:572-84. 2006
    ..These observations support NrCAM as a positionally cloned and drug-regulated gene whose variants are likely to change expression and alter substance abuse vulnerabilities in human addictions and animal models of drug reward...
  23. ncbi request reprint Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: possible haplotype association of nuclear-related receptor 1 gene to alcohol
    Hiroki Ishiguro
    Department of Medical Genetics, Institute of Basic Medical Science, University of Tsukuba, Ibaraki, Japan
    Am J Med Genet 114:15-23. 2002
    ....
  24. pmc NrCAM-regulating neural systems and addiction-related behaviors
    Hiroki Ishiguro
    Department of Neuropsychiatry and Clinical Ethics, Graduate School of Medical Science, University of Yamanashi, Chuo, Yamanashi, Japan Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Addict Biol 19:343-53. 2014
    ..Thus, NrCAM could affect addiction-related behaviors via at least partially modulation of some glutamatergic pathways and neural function in brain. ..
  25. ncbi request reprint Molecular neurobiological methods in marijuana-cannabinoid research
    George R Uhl
    Molecular Neurobiology Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Methods Mol Med 123:1-17. 2006
    ....
  26. doi request reprint Functional polymorphism in the GPR55 gene is associated with anorexia nervosa
    Hiroki Ishiguro
    Department of Psychiatry, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Synapse 65:103-8. 2011
    ..023, Odds ratio = 1.31 (95% Cl = 1.03-1.37), P = 0.0048, OR = 2.41 (95% Cl = 1.34-4.34), respectively). In conclusion, the low-functioning Val195 allele of GPR55 appears to be a risk factor for anorexia nervosa...
  27. ncbi request reprint Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain
    Emmanuel S Onaivi
    Department of Biology, William Paterson University, Wayne, NJ 07470, USA
    Ann N Y Acad Sci 1074:514-36. 2006
    ....
  28. pmc Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects
    Emmanuel S Onaivi
    Department of Biology, William Paterson University, Wayne, New Jersey, USA
    PLoS ONE 3:e1640. 2008
    ..Therefore, neuronal expression of CB2-Rs had been ambiguous and controversial and its role in depression and substance abuse is unknown...
  29. ncbi request reprint Methods to study the behavioral effects and expression of CB2 cannabinoid receptor and its gene transcripts in the chronic mild stress model of depression
    Emmanuel S Onaivi
    Department of Biology, William Paterson University, Wayne, NJ, USA
    Methods Mol Med 123:291-8. 2006
    ..These preliminary results, if confirmed, suggest that the CB2 receptors are expressed in the mammalian brain and may be involved in depression and substance abuse...
  30. doi request reprint Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia
    Toshiya Inada
    Seiwa Hospital, Institute of Neuropsychiatry, Benten cho 91, Shinjuku ku, Tokyo, Japan
    Pharmacogenet Genomics 18:317-23. 2008
    ..In this study, a genome-wide association screening was done to identify the pathway(s) in which genetic variations influence susceptibility to neuroleptic-induced TD...
  31. ncbi request reprint Failure to find association between PRODH deletion and schizophrenia
    Tsuyuka Ohtsuki
    Schizophr Res 67:111-3. 2004
  32. ncbi request reprint Ibogaine signals addiction genes and methamphetamine alteration of long-term potentiation
    Emmanuel S Onaivi
    Department of Biology, William Paterson University, Wayne, New Jersey 07470, USA
    Ann N Y Acad Sci 965:28-46. 2002
    ..It is therefore tempting to suggest that ibogaine signals addiction gene products...
  33. ncbi request reprint Endocannabinoids and cannabinoid receptor genetics
    Emmanuel S Onaivi
    Department of Biology, William Paterson University, 07470, Wayne, NJ, USA
    Prog Neurobiol 66:307-44. 2002
    ..Therefore, understanding the physiological cannabinoid control system in the human body and brain will contribute to elucidating this natural regulatory mechanism in health and disease...
  34. doi request reprint Replication study for associations between polymorphisms in the CLDN5 and DGCR2 genes in the 22q11 deletion syndrome region and schizophrenia
    Hiroki Ishiguro
    Psychiatr Genet 18:255-6. 2008
  35. ncbi request reprint Clofibrate treatment promotes branched-chain amino acid catabolism and decreases the phosphorylation state of mTOR, eIF4E-BP1, and S6K1 in rat liver
    Hiroki Ishiguro
    Department of Gastroenterology, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Life Sci 79:737-43. 2006
    ..These results suggest that BCAA catabolism enhanced by clofibrate treatment has significant influences on the leucine-induced activation of translation initiation processes...