Kunitoshi Iseki

Summary

Affiliation: University of the Ryukyus
Country: Japan

Publications

  1. ncbi request reprint [Epidemiology of CKD in Japan]
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus
    Nihon Rinsho 66:1650-6. 2008
  2. doi request reprint Changes in serum uric acid have a reciprocal effect on eGFR change: a 10-year follow-up study of community-based screening in Okinawa, Japan
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Okinawa General Health Maintenance Association, Nishihara, Okinawa, Japan
    Hypertens Res 36:650-4. 2013
  3. pmc Nephrology for the people: Presidential Address at the 42nd Regional Meeting of the Japanese Society of Nephrology in Okinawa 2012
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0215, Japan
    Clin Exp Nephrol 17:480-7. 2013
  4. doi request reprint Effects of angiotensin receptor blockade (ARB) on mortality and cardiovascular outcomes in patients with long-term haemodialysis: a randomized controlled trial
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Nishihara, Okinawa, Japan
    Nephrol Dial Transplant 28:1579-89. 2013
  5. doi request reprint Effect of glomerular filtration rate and proteinuria on medical cost among screened subjects
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Okinawa, 903 0215, Japan
    Clin Exp Nephrol 17:372-8. 2013
  6. doi request reprint Stroke feature and management in dialysis patients
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Okinawa, Japan
    Contrib Nephrol 179:100-9. 2013
  7. doi request reprint Risk factor profiles based on estimated glomerular filtration rate and dipstick proteinuria among participants of the Specific Health Check and Guidance System in Japan 2008
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0215, Japan
    Clin Exp Nephrol 16:244-9. 2012
  8. ncbi request reprint Successful management of critical limb ischemia with intravenous sodium thiosulfate in a chronic hemodialysis patient
    K Tokashiki
    Department of Cardiovascular Medicine, Nephrology and Neurology, Faculty of Medicine, University Hospital of the Ryukyus, Okinawa, Japan
    Clin Nephrol 66:140-3. 2006
  9. doi request reprint Geographic difference in the prevalence of chronic kidney disease among Japanese screened subjects: Ibaraki versus Okinawa
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa, Japan
    Clin Exp Nephrol 13:44-9. 2009
  10. ncbi request reprint Risk of developing low glomerular filtration rate or elevated serum creatinine in a screened cohort in Okinawa, Japan
    Kunitoshi Iseki
    Dialysis Unit and Third Department of Internal Medicine, University Hospital of the Ryukyus, Japan
    Hypertens Res 30:167-74. 2007

Detail Information

Publications96

  1. ncbi request reprint [Epidemiology of CKD in Japan]
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus
    Nihon Rinsho 66:1650-6. 2008
    ..Early detection through urine test for proteinuria and measurement of serum creatinine is strongly recommended. Goal of treatment of CKD is to decrease the incidence of ESRD and cardiovascular disease...
  2. doi request reprint Changes in serum uric acid have a reciprocal effect on eGFR change: a 10-year follow-up study of community-based screening in Okinawa, Japan
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Okinawa General Health Maintenance Association, Nishihara, Okinawa, Japan
    Hypertens Res 36:650-4. 2013
    ..The results suggest that maintaining a normal range of UA is important to maintain eGFR decline in a normal range...
  3. pmc Nephrology for the people: Presidential Address at the 42nd Regional Meeting of the Japanese Society of Nephrology in Okinawa 2012
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0215, Japan
    Clin Exp Nephrol 17:480-7. 2013
    ..CKD is a strong risk factor for developing cardiovascular disease and death and also plays an important role in infection and malignancies, particularly in elderly people. People can live longer with healthy kidneys...
  4. doi request reprint Effects of angiotensin receptor blockade (ARB) on mortality and cardiovascular outcomes in patients with long-term haemodialysis: a randomized controlled trial
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Nishihara, Okinawa, Japan
    Nephrol Dial Transplant 28:1579-89. 2013
    ....
  5. doi request reprint Effect of glomerular filtration rate and proteinuria on medical cost among screened subjects
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Okinawa, 903 0215, Japan
    Clin Exp Nephrol 17:372-8. 2013
    ..Therefore, the medical expenses are higher with the decrease in glomerular filtration rate (GFR). However, few studies have examined the medical expenses according to the baseline GFR...
  6. doi request reprint Stroke feature and management in dialysis patients
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Okinawa, Japan
    Contrib Nephrol 179:100-9. 2013
    ..Use of warfarin is controversial in case of acute cerebral infarction. Modification of dialysis modality is needed to prevent the increase in intracranial pressure and/or recurrence of stroke...
  7. doi request reprint Risk factor profiles based on estimated glomerular filtration rate and dipstick proteinuria among participants of the Specific Health Check and Guidance System in Japan 2008
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0215, Japan
    Clin Exp Nephrol 16:244-9. 2012
    ..Few studies, however, have examined the risk factor profiles based on eGFR and proteinuria among the general population...
  8. ncbi request reprint Successful management of critical limb ischemia with intravenous sodium thiosulfate in a chronic hemodialysis patient
    K Tokashiki
    Department of Cardiovascular Medicine, Nephrology and Neurology, Faculty of Medicine, University Hospital of the Ryukyus, Okinawa, Japan
    Clin Nephrol 66:140-3. 2006
    ..Pain relief was sustained and he could walk after 2 weeks of infusion. Our case supports the use of sodium thiosulfate as a novel therapeutic choice for critical limb ischemia with severe vascular calcification in chronic HD patients...
  9. doi request reprint Geographic difference in the prevalence of chronic kidney disease among Japanese screened subjects: Ibaraki versus Okinawa
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa, Japan
    Clin Exp Nephrol 13:44-9. 2009
    ..Few epidemiologic studies, however, have compared the prevalence of chronic kidney disease (CKD) among different geographic areas. Other than genetic factors, socioeconomic conditions and lifestyle are targets for modification...
  10. ncbi request reprint Risk of developing low glomerular filtration rate or elevated serum creatinine in a screened cohort in Okinawa, Japan
    Kunitoshi Iseki
    Dialysis Unit and Third Department of Internal Medicine, University Hospital of the Ryukyus, Japan
    Hypertens Res 30:167-74. 2007
    ....
  11. ncbi request reprint Body mass index and the risk of chronic renal failure: the Asian experience
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Okinawa, Japan
    Contrib Nephrol 151:42-56. 2006
    ..Although the effect of obesity might differ among races, obesity has a significant impact on CKD and ESRD...
  12. ncbi request reprint Increasing gender difference in the incidence of chronic dialysis therapy in Japan
    Kunitoshi Iseki
    University Hospital of the Ryukyus, Okinawa, Japan
    Ther Apher Dial 9:407-11. 2005
    ..Differences in the socioeconomic conditions and lifestyles between men and women, which might be related to the gender difference in incidence in ESRD, should be studied further...
  13. ncbi request reprint Predictors of diabetic end-stage renal disease in Japan
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Nishihara, Okinawa, Japan
    Nephrology (Carlton) 10:S2-6. 2005
    ..Knowledge of the predictors of DM-ESRD is crucial as a first step toward prevention. Consistent with this notion, initiatives on the management of CKD and ESRD were recently organized in Japan and internationally...
  14. ncbi request reprint Changes in the demographics and prevalence of chronic kidney disease in Okinawa, Japan (1993 to 2003)
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Okinawa, Japan
    Hypertens Res 30:55-62. 2007
    ....
  15. ncbi request reprint Relationship between dyslipidemia and the risk of developing end-stage renal disease in a screened cohort
    Kunitoshi Iseki
    University of the Ryukyus, 207 Uehara, Okinawa 903 0215, Japan
    Clin Exp Nephrol 9:46-52. 2005
    ..However, few studies have examined abnormal lipid metabolism as a risk factor for the development of ESRD in the general population...
  16. ncbi request reprint Factors influencing the development of end-stage renal disease
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Clin Exp Nephrol 9:5-14. 2005
    ..In addition, the economic burden caused by the costs of dialysis presents a compelling argument for implementing a cost-effective preventive strategy against ESRD...
  17. ncbi request reprint Relationship between predicted creatinine clearance and proteinuria and the risk of developing ESRD in Okinawa, Japan
    Kunitoshi Iseki
    Dialysis Unit and Third Department of Internal Medicine, University Hospital of the Ryukyus, Okinawa, Japan
    Am J Kidney Dis 44:806-14. 2004
    ..Chronic kidney disease and a low creatinine clearance (CrCl) are relatively common, particularly in the aged population. However, the renal outcome of a low CrCl is not known...
  18. ncbi request reprint Prevalence and determinants of hypertension in chronic hemodialysis patients in Japan
    Kunitoshi Iseki
    Patient Registration Committee of Japanese Society for Dialysis Therapy, Tokyo, Japan
    Ther Apher Dial 11:183-8. 2007
    ..Despite the high prescription rate of antihypertensive drugs, control of blood pressure remains unsatisfactory...
  19. doi request reprint Pharmacological control of secondary hyperparathyroidism in chronic hemodialysis patients: cinacalcet is coming to Japan
    Kunitoshi Iseki
    University Hospital of Ryukyus, Dialysis Unit, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Expert Opin Pharmacother 9:601-10. 2008
    ..Dietary phosphate restriction and adequate hemodialysis, however, are still the main strategy for the control of hyperphosphatemia and secondary hyperparathyroidism...
  20. doi request reprint High Prevalence of chronic kidney disease among patients with sleep related breathing disorder (SRBD)
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Okinawa, Japan
    Hypertens Res 31:249-55. 2008
    ..0 kg/m2); in the controls the values were 8.1%, 10.5%, and 10.6%, respectively. Taken together, these results suggest that surveillance of CKD is warranted among SRBD patients, particularly those who are not obese...
  21. doi request reprint Role of chronic kidney disease in cardiovascular disease: are we different from others?
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Clin Exp Nephrol 15:450-5. 2011
    ..The Japanese population is rapidly aging and will have the largest proportion of elderly people in the world. A systematic strategy for managing CKD patients is warranted...
  22. doi request reprint Tachycardia as a predictor of poor survival in chronic haemodialysis patients
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Nephrol Dial Transplant 26:963-9. 2011
    ..High pulse rate is a culprit of all causes of death in the general population, but its relation to death in haemodialysis (HD) patients has not been examined in a large patient cohort...
  23. doi request reprint C-reactive protein is a predictor for developing proteinuria in a screened cohort
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Nishihara, Okinawa, Japan
    Nephron Clin Pract 117:c51-6. 2011
    ..The relationship between C-reactive protein (CRP) and proteinuria is not known...
  24. doi request reprint Renal outcomes in chronic kidney disease
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Nishihara, Okinawa, Japan
    Nephrology (Carlton) 15:27-30. 2010
    ..Benefits of proteinuria screening and automatic reporting of estimated glomerular filtration rate on the incidence of ESRD remain to be determined...
  25. doi request reprint Higher survival rates of chronic hemodialysis patients on anti-hypertensive drugs
    K Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Nishihara, Okinawa, Japan
    Nephron Clin Pract 113:c183-90. 2009
    ..The effects of anti-hypertensive drugs on survival have not been examined in a large cohort of hemodialysis (HD) patients...
  26. doi request reprint Olmesartan clinical trial in Okinawan patients under OKIDS (OCTOPUS) study: design and methods
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0215, Japan
    Clin Exp Nephrol 13:145-51. 2009
    ..Survival is much better among hypertensive patients than normal to hypotensive patients. Target levels of blood pressure and the class of antihypertensive drugs have not been examined in prospective studies...
  27. doi request reprint Chronic kidney disease in Japan from early predictions to current facts
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Okinawa, Japan
    Nephron Clin Pract 110:c268-72. 2008
    ..73 m(2)) to be around 10% of the community-based screening participants. However, such a high CKD prevalence requires detailed and critical confirmatory studies and analyses, many of which are currently underway in Japan...
  28. doi request reprint Gender differences in chronic kidney disease
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Okinawa, Japan
    Kidney Int 74:415-7. 2008
    ..Women live longer than men. Can this phenomenon be explained by chronic kidney disease (CKD)? Gender differences in the prevalence and incidence of CKD are discussed...
  29. doi request reprint Proteinuria and decreased body mass index as a significant risk factor in developing end-stage renal disease
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0215, Japan
    Clin Exp Nephrol 12:363-9. 2008
    ..Body mass index (BMI) is a significant predictor of developing end-stage renal disease (ESRD). The relation between a change in BMI (DeltaBMI) and the incidence of ESRD has not been examined in any large epidemiologic studies...
  30. ncbi request reprint Chronic kidney disease in Japan
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Okinawa
    Intern Med 47:681-9. 2008
    ..Early detection and treatment of CKD are necessary to decrease the incidence of ESRD and cardiovascular disease...
  31. ncbi request reprint Prevalence of high fasting plasma glucose and risk of developing end-stage renal disease in screened subjects in Okinawa, Japan
    Kunitoshi Iseki
    Dialysis Unit, University of the Ryukyus, 207 Uehara, Okinawa 903 0215, Japan
    Clin Exp Nephrol 8:250-6. 2004
    ..Only a few studies, however, have examined the effect of diabetes mellitus (DM) as a risk factor for the development of end-stage renal disease (ESRD) in the general population...
  32. ncbi request reprint Significance of hyperuricemia as a risk factor for developing ESRD in a screened cohort
    Kunitoshi Iseki
    Dialysis Unit and Third Department of Internal Medicine, University Hospital of the Ryukyus, Okinawa, Japan
    Am J Kidney Dis 44:642-50. 2004
    ..However, epidemiological evidence for the significance of serum uric acid levels on the risk for developing end-stage renal disease (ESRD) is scarce in a setting of community-based screening...
  33. ncbi request reprint Outcome study of renal biopsy patients in Okinawa, Japan
    Kunitoshi Iseki
    Dialysis Unit and Third Department of Internal Medicine, University of the Ryukyus, Okinawa Chubu Hospital, Japan
    Kidney Int 66:914-9. 2004
    ..855, 95% CI 0.711-1.028, P= 0.095). The clinical significance of renal biopsy, other than its provision of histologic evidence, remains to be shown...
  34. ncbi request reprint The okinawa screening program
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Okinawa, Japan
    J Am Soc Nephrol 14:S127-30. 2003
    ..The effects of age, obesity, and hypercholesterolemia were insignificant, but this needs to be confirmed in a larger cohort and other registries...
  35. ncbi request reprint Hypocholesterolemia is a significant predictor of death in a cohort of chronic hemodialysis patients
    Kunitoshi Iseki
    Dialysis Unit and Third Department of Internal Medicine, University of the Ryukyus, Okinawa, Japan
    Kidney Int 61:1887-93. 2002
    ..Although hypocholesterolemia is common in chronic hemodialysis patients, its effect on survival has not been studied in a large patients population...
  36. ncbi request reprint Significance of hyperuricemia on the early detection of renal failure in a cohort of screened subjects
    K Iseki
    Dialysis Unit, University of the Ryukyus, Okinawa, Japan
    Hypertens Res 24:691-7. 2001
    ..0 mg/dl. Prevalence of high levels of S-Cr was relatively high in men. Other than gender, serum uric acid was a significant positive correlate of developing high S-Cr in this sample of the Japanese population...
  37. ncbi request reprint Estimated protein intake and blood pressure in a screened cohort in Okinawa, Japan
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Uehara, Okinawa, Japan
    Hypertens Res 26:289-94. 2003
    ..In summary, estimated daily protein intake was about 1.1 g/kg in men and 1.0 g/kg in women. Despite the higher urinary excretion of Na, both SBP and DBP tended to be lower in those with higher daily protein intake, particularly in men...
  38. ncbi request reprint Effect of the duration of dialysis on survival in a cohort of chronic haemodialysis patients
    Kunitoshi Iseki
    Dialysis Unit and Third Department of Internal Medicine, University of the Ryukyus, Okinawa, Japan
    Nephrol Dial Transplant 18:782-7. 2003
    ..Whether the length of dialysis treatment in chronic HD patients is a significant independent risk factor of death is not clear...
  39. ncbi request reprint Proteinuria and the risk of developing end-stage renal disease
    Kunitoshi Iseki
    Dialysis Unit and Third Department of Internal Medicine, University of The Ryukyus and Okinawa General Health Maintenance Association, Okinawa, Japan
    Kidney Int 63:1468-74. 2003
    ..Dipstick urinalysis for proteinuria and hematuria has been used to screen renal disease, but evidence of the clinical impact of this test on development of end-stage renal disease (ESRD) is lacking...
  40. ncbi request reprint A patient with adult-onset type II citrullinemia on long-term hemodialysis: reversal of clinical symptoms and brain MRI findings
    Saori Oshiro
    Third Department of Internal Medicine and Dialysis Unit, University of the Ryukyus, Okinawa, Japan
    Am J Kidney Dis 39:189-92. 2002
    ..Such intensified dialysis therapy may be effective for adult-onset type II citrullinemia and may be applicable even in patients who do not have end-stage renal disease if liver transplant is not an option...
  41. ncbi request reprint Demographic trends in the Okinawa Dialysis Study (OKIDS) registry (1971-2000)
    Kunitoshi Iseki
    Dialysis Unit and Third Department of Internal Medicine, University of the Ryukyus, Okinawa, Japan
    Kidney Int 61:668-75. 2002
    ..The clinical demographics of chronic dialysis patients are changing worldwide. However, long-term data from regional dialysis registries have not yet been analyzed and reported...
  42. ncbi request reprint Determinants of prescribed dialysis dose and survival in a cohort of chronic hemodialysis patients
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, 207 Uehara, Okinawa 903 0215, Japan
    Clin Exp Nephrol 7:231-7. 2003
    ..The Determinants of the prescribed dialysis dose have not been well studied in a large patient population. Few studies have examined survival rates after adjusting for dose determinants...
  43. ncbi request reprint Prevalence and correlates of diabetes mellitus in a screened cohort in Okinawa, Japan
    Kunitoshi Iseki
    Dialysis Unit, University of the Ryukyus, Okinawa, Japan
    Hypertens Res 25:185-90. 2002
    ..90 (1.14-3.17). The results indicated that the prevalence and incidence of DM were high among this screened cohort in Okinawa, Japan. Subjects with proteinuria may thus be at high risk for developing DM...
  44. ncbi request reprint Evidence for high incidence of end-stage renal disease in patients after stroke and acute myocardial infarction at age 60 or younger
    K Iseki
    Dialysis Unit and Third Department of Internal Medicine, University of the Ryukyus, Okinawa, Japan
    Am J Kidney Dis 38:1235-9. 2001
    ..The present results confirm that survivors after stroke or AMI have a greater incidence of ESRD than those in the general population, in particular, those who had stroke or AMI at 60 years or younger...
  45. ncbi request reprint Factors influencing long-term survival in patients on chronic dialysis
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Clin Exp Nephrol 8:89-97. 2004
    ..In this article, both the JSDT registry and OKIDS data are reviewed in order to identify factors related to the survival of chronic dialysis patients...
  46. ncbi request reprint Long-term prognosis and incidence of acute myocardial infarction in patients on chronic hemodialysis. The Okinawa Dialysis Study Group
    K Iseki
    Dialysis Unit and Third Department of Internal Medicine, University of the Ryukyus, Okinawa, Japan
    Am J Kidney Dis 36:820-5. 2000
    ..5% at 12 months, and 13.0% at 44 months. Patients with diabetes mellitus (DM) had a greater incidence of AMI and a worse prognosis than patients without DM. The long-term prognosis of AMI was poor in chronic dialysis patients...
  47. ncbi request reprint Urinary excretion of sodium and potassium in a screened cohort in Okinawa, Japan
    Kunitoshi Iseki
    Dialysis Unit, University of the Ryukyus, Uehara, Okinawa, Japan
    Hypertens Res 25:731-6. 2002
    ..Sodium excretion, however, was higher in young men than in elderly subjects, and K excretion was lower in young women than in elderly subjects. Both trends are disadvantageous for controlling hypertension...
  48. ncbi request reprint Body mass index and the risk of development of end-stage renal disease in a screened cohort
    Kunitoshi Iseki
    Dialysis Unit and Third Department of Internal Medicine, University of the Ryukyus, Okinawa, Japan
    Kidney Int 65:1870-6. 2004
    ..However, few studies have examined the significance of body mass index (BMI) as a risk factor for the development of ESRD in the general population...
  49. doi request reprint Decreased body mass index as an independent risk factor for developing chronic kidney disease
    Kaori Tokashiki
    Department of Cardiovascular Medicine, Nephrology, and Neurology, Faculty of Medicine and Dialysis Unit, University Hospital of The Ryukyus and Okinawa General Health Maintenance Association, Okinawa, Japan
    Clin Exp Nephrol 13:55-60. 2009
    ..Obesity and metabolic syndrome are risk factors for the development of chronic kidney disease (CKD). Few studies have examined the effect of change in body mass index (DeltaBMI) on CKD incidence in a general screening setting...
  50. doi request reprint Overview of regular dialysis treatment in Japan (as of 31 December 2008)
    Shigeru Nakai
    Renal Data Registry Committee, Japanese Society for Dialysis Therapy, Tokyo, Japan
    Ther Apher Dial 14:505-40. 2010
    ..The risk of becoming HCV-positive was high in patients with low serum creatinine, serum albumin, and serum total cholesterol levels, and/or a low body mass index before beginning dialysis...
  51. doi request reprint Overview of regular dialysis treatment in Japan as of 31 December 2006
    Shigeru Nakai
    Committee of Renal Data Registry, Japanese Society for Dialysis Therapy, Tokyo, Japan
    Ther Apher Dial 12:428-56. 2008
    ..37 +/- 3.58 mg/dL. The estimated glomerular filtration rate, which was calculated with formula modified for the Japanese population from the Modification of Diet in Renal Disease (MDRD) Study equation, was 5.46 +/- 6.60 mL/min/1.73 m(2)...
  52. ncbi request reprint Hyperuricemia as a predictor of hypertension in a screened cohort in Okinawa, Japan
    Kazufumi Nagahama
    Department of Cardiovascular Medicine, Nephrology and Neurology, Faculty of Medicine, University of the Ryukyus, Nakagami gun, Okinawa, Japan
    Hypertens Res 27:835-41. 2004
    ..48 (1.08-2.02) and in women was 1.90 (1.03-3.51) (p <0.05, respectively). The results showed hyperuricemia to be a new predictor of hypertension development in both men and women...
  53. doi request reprint An overview of regular dialysis treatment in Japan (as of 31 December 2007)
    Shigeru Nakai
    Patient Registration Committee, Japanese Society for Dialysis Therapy, Tokyo, Japan
    Ther Apher Dial 13:457-504. 2009
    ..The serum creatinine level of patients upon introduction to dialysis was 8.34 (+/-3.55) mg/dL, and the estimated glomerular filtration rate was 5.43 (+/-3.43) mL/min/1.73 m(2) for the patients who were newly begun on dialysis in 2007...
  54. doi request reprint Elevated resting heart rate is associated with white blood cell count in middle-aged and elderly individuals without apparent cardiovascular disease
    Taku Inoue
    Center of Residency and Fellowship Program, Faculty of Medicine, University Hospital of the Ryukyus, Uehara, Nishihara, Okinawa, Japan
    Angiology 63:541-6. 2012
    ..3 in both men and women. These findings indicate the clinical significance of resting HR for identifying individuals at risk of subclinical inflammation and a future cardiovascular event...
  55. ncbi request reprint Evidence for elevated pulse pressure in patients on chronic hemodialysis: a case-control study
    Masahiko Tozawa
    Third Department of Internal Medicine, University of the Ryukyus, Okinawa, Japan
    Kidney Int 62:2195-201. 2002
    ..We retrospectively examined PP in a large cohort of hemodialysis patients and healthy control subjects...
  56. doi request reprint An overview of regular dialysis treatment in Japan (as of 31 December 2010)
    Shigeru Nakai
    Committee of Renal Data Registry, Japanese Society for Dialysis Therapy, Tokyo, Japan
    Ther Apher Dial 16:483-521. 2012
    ..0%; 2010, 23.2%). A total weekly Kt/V attributable to peritoneal dialysis and their residual functional kidney was 1.7 or higher for 59.4% of patients who underwent peritoneal dialysis...
  57. doi request reprint Overview of regular dialysis treatment in Japan (as of 31 December 2009)
    Shigeru Nakai
    Committee of Renal Data Registry, Japanese Society for Dialysis Therapy, Tokyo, Japan
    Ther Apher Dial 16:11-53. 2012
    ..e. serum calcium concentration, serum phosphorus concentration, and serum intact parathyroid hormone concentration. According to the questionnaire, 9.8% of the patients were considered to have a complication of dementia...
  58. ncbi request reprint Hyperuricemia and cardiovascular risk factor clustering in a screened cohort in Okinawa, Japan
    Kazufumi Nagahama
    Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, Okinawa, Japan
    Hypertens Res 27:227-33. 2004
    ..The present study revealed that hyperuricemia is positively associated with obesity, hypertension, and dyslipidemia in both men and women, and that hyperuricemic subjects tend to have a clustering of these cardiovascular risk factors...
  59. ncbi request reprint Higher heart rate predicts the risk of developing hypertension in a normotensive screened cohort
    Taku Inoue
    Cardiovascular Division, Heart Life Hospital, Okinawa, Japan
    Circ J 71:1755-60. 2007
    ..Hypertension is an important cardiovascular risk factor. The present study evaluated whether a higher HR was associated with the development of hypertension in normotensive, screened subjects...
  60. doi request reprint Effect of heart rate on the risk of developing metabolic syndrome
    Taku Inoue
    Department of Clinical Pharmacology and Therapeutics, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    Hypertens Res 32:801-6. 2009
    ..2-fold increase in the risk of developing metabolic syndrome for men only, even after adjusting for age and lifestyle. Elevated heart rate is a risk factor for developing metabolic syndrome in men...
  61. doi request reprint Elevated resting heart rate is an independent predictor of all-cause death and cardiovascular events in Japanese ambulatory hemodialysis patients
    Taku Inoue
    Center of Residency and Fellowship Program, Faculty of Medicine, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Clin Exp Nephrol 16:938-44. 2012
    ..Elevated heart rate (HR) is an independent risk factor for all-cause death or cardiovascular events in non-hemodialysis subjects; however, the clinical significance of elevated HR in hemodialysis patients is not well studied...
  62. ncbi request reprint Overview of regular dialysis treatment in Japan (as of 31 December 2005)
    Shigeru Nakai
    Patient Registration Committee, Japanese Society for Dialysis Therapy, Tokyo, Japan
    Ther Apher Dial 11:411-41. 2007
    ..Results showed that the mean life expectancy of the dialysis population was approximately 40-60% of that of the general population of the same sex and age...
  63. ncbi request reprint Triglyceride, but not total cholesterol or low-density lipoprotein cholesterol levels, predict development of proteinuria
    Masahiko Tozawa
    Third Department of Internal Medicine and Dialysis Unit, University of the Ryukyus, and Okinawa General Health Maintenance Association, Okinawa, Japan
    Kidney Int 62:1743-9. 2002
    ....
  64. ncbi request reprint Impact of multiple risk factor clustering on the elevation of blood pressure
    Masahiko Tozawa
    Third Department of Internal Medicine and Dialysis Unit, University of the Ryukyus, Okinawa General Health Maintenance Association, Okinawa, Japan
    Hypertens Res 25:811-6. 2002
    ..51 (p = 0.001) for increase in systolic BP, and 0.31 (p = 0.008) for increase in diastolic BP after adjusting for age and sex. In conclusion, clustering of risk factors significantly predicted the development of hypertension...
  65. doi request reprint Heart rate as a risk factor for developing chronic kidney disease: longitudinal analysis of a screened cohort
    Taku Inoue
    Department of Clinical Pharmacology and Therapeutics, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0215, Japan
    Clin Exp Nephrol 13:487-93. 2009
    ..High heart rate and chronic kidney disease (CKD) are both risk factors for cardiovascular morbidity and mortality. The relationship between heart rate and the risk of developing CKD, however, has not been studied in a large screened cohort...
  66. doi request reprint Prevalence of anemia according to stage of chronic kidney disease in a large screening cohort of Japanese
    Kentaro Kohagura
    Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, Nishihara cho, Okinawa, Japan
    Clin Exp Nephrol 13:614-20. 2009
    ..The prevalence of chronic kidney disease (CKD) is high in developed countries, including Japan. However, little is known about the prevalence of anemia according to the estimated glomerular filtration rate (eGFR) among Japanese...
  67. ncbi request reprint Analysis of drug prescription in chronic haemodialysis patients
    Masahiko Tozawa
    Third Department of Internal Medicine and Dialysis Unit, University of the Ryukyus, Okinawa, Japan
    Nephrol Dial Transplant 17:1819-24. 2002
    ..We surveyed prescribed medications and examined the relation between the number of medications and mortality and clinical characteristics in chronic haemodialysis patients, in Okinawa, Japan...
  68. ncbi request reprint An overview of regular dialysis treatment in Japan (as of 31 December 2004)
    Shigeru Nakai
    Patient Registration Committee, Japanese Society for Dialysis Therapy, Tokyo, Japan
    Ther Apher Dial 10:476-97. 2006
    ..The percentage of patients who received PEIT again was 35.0%. The percentage of patients who had been on hemodialysis for more than 10 years and received PEIT again was more than 50%...
  69. ncbi request reprint The most recent trends of peritoneal dialysis in Japan
    Ikuto Masakane
    Patient Registration Committee, Japanese Society for Dialysis Therapy, Tokyo, Japan
    Perit Dial Int 28:S27-31. 2008
    ..Use of PD for older and diabetic patients and of combination therapy with hemodialysis are key perspectives in the most recent report on PD in Japan...
  70. doi request reprint Association between prehypertension and chronic kidney disease in the Japanese general population
    Yuichiro Yano
    Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Kidney Int 81:293-9. 2012
    ..Thus, the prevalence of CKD increased with the severity of blood pressure. Prehypertension with high-normal blood pressure, particularly in conjunction with obesity, was found to be an independent risk factor of CKD in men...
  71. ncbi request reprint Influence of smoking and obesity on the development of proteinuria
    Masahiko Tozawa
    Third Department of Internal Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    Kidney Int 62:956-62. 2002
    ..The aim of this study was to analyze the effects of obesity and smoking on the development of proteinuria in a screened cohort of subjects with normal kidney function...
  72. ncbi request reprint Blood pressure predicts risk of developing end-stage renal disease in men and women
    Masahiko Tozawa
    Third Department of Internal Medicine and Dialysis Unit, University of the Ryukyus, Okinawa General Health Maintenance Association, Okinawa, Japan
    Hypertension 41:1341-5. 2003
    ..Control of blood pressure within normal levels should be stressed as a strategy to prevent end-stage renal disease in both men and women...
  73. ncbi request reprint Proteinuria as a significant determinant of hypertension in a normotensive screened cohort in Okinawa, Japan
    Taku Inoue
    Cardiovascular Division, Heart Life Hospital, Okinawa, Japan
    Hypertens Res 29:687-93. 2006
    ..Age and obesity are also associated with increased risk of hypertension. Lifestyle modification might thus be necessary, particularly in subjects with proteinuria...
  74. ncbi request reprint Plasma aldosterone in hypertensive patients on chronic hemodialysis: distribution, determinants and impact on survival
    Kentaro Kohagura
    Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, Okinawa, Japan
    Hypertens Res 29:597-604. 2006
    ..The association between lower PAC and poor survival may be driven by volume retention and/or lower potassium...
  75. ncbi request reprint Impact of high coronary artery calcification score (CACS) on survival in patients on chronic hemodialysis
    Mitsuteru Matsuoka
    Third Department of Internal Medicine, University Hospital of the Ryukyus, Okinawa, Japan
    Clin Exp Nephrol 8:54-8. 2004
    ..Whether the coronary artery calcification score (CACS) is a prognostic marker in chronic dialysis patients is not known...
  76. ncbi request reprint Increased pulse wave velocity is associated with low creatinine clearance and proteinuria in a screened cohort
    Yusuke Ohya
    Department of Cardiovascular Medicine, Nephrology, and Neurology, University of the Ryukyus, Japan
    Am J Kidney Dis 47:790-7. 2006
    ....
  77. ncbi request reprint Effects of blood pressure levels on case fatality after acute stroke
    Koichiro Okumura
    Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus, School of Medicine, Okinawa, Japan
    J Hypertens 23:1217-23. 2005
    ..We evaluated the relationship between admission blood pressure (BP) and early prognosis in patients with acute stroke in a single cohort...
  78. ncbi request reprint Pulse pressure and risk of total mortality and cardiovascular events in patients on chronic hemodialysis
    Masahiko Tozawa
    Third Department of Internal Medicine and Dialysis Unit, University of the Ryukyus, Okinawa, Japan
    Kidney Int 61:717-26. 2002
    ....
  79. ncbi request reprint Progression of renal failure delayed by use of losartan in a case of IgA nephropathy
    Kunitoshi Iseki
    Dialysis Unit, University of the Ryukyus, Nishihara, Okinawa
    Intern Med 41:1167-70. 2002
    ..06 ml/min/1.73 m2/month. We document successful retardation of renal failure with the use of losartan. Our experience suggests that dialysis therapy can be delayed significantly in patients using this drug...
  80. ncbi request reprint rHuEPO dose inversely correlated with the number of circulating CD34+ cells in maintenance hemodialysis patients
    Kentaro Kohagura
    Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus School of Medicine, Okinawa, Japan
    Nephron Clin Pract 108:c41-6. 2008
    ..However, it has not been examined whether there is correlation between the numbers of CD34+ cells, including EPCs and erythroid progenitor cells, and the dose of rHuEPO in MHD patients...
  81. ncbi request reprint Metabolic syndrome and chronic kidney disease: a Japanese perspective on a worldwide problem
    Kunitoshi Iseki
    Dialysis Unit, University Hospital of the Ryukyus, Nishihara, Okinawa, Japan
    J Nephrol 21:305-12. 2008
    ..Research on the relationship between CKD and metabolic syndrome may provide clues to better understand the role of lifestyle-related factors and the age-related decline in GFR...
  82. ncbi request reprint Cardiovascular risk factors associated with pulse pressure in a screened cohort in Okinawa, Japan
    Taku Inoue
    Third Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Hypertens Res 26:153-8. 2003
    ..In conclusion, higher PP was associated with cardiovascular risk factors. These associations were similar in both men and women...
  83. ncbi request reprint Haematocrit and the risk of developing end-stage renal disease
    Kunitoshi Iseki
    Dialysis Unit and Third Department of Internal Medicine, University of the Ryukyus, 207 Uehara, Okinawa 903 0215, Japan
    Nephrol Dial Transplant 18:899-905. 2003
    ..Anaemia is common in patients with renal failure; however, it is not known whether haematocrit level in the general population is a predictor for developing end-stage renal disease (ESRD)...
  84. ncbi request reprint Metabolic syndrome and risk of developing chronic kidney disease in Japanese adults
    Masahiko Tozawa
    Ikejiri ohasi Jin Clinic, Tokyo, Japan
    Hypertens Res 30:937-43. 2007
    ..Metabolic syndrome is a significant risk factor for the development of CKD in the Japanese population. Detection and treatment of metabolic syndrome should be stressed as a strategy to prevent CKD...
  85. ncbi request reprint An overview of regular dialysis treatment in Japan (as of 31 December 2001)
    Shigeru Nakai
    Ther Apher Dial 8:3-32. 2004
    ....
  86. ncbi request reprint Screening for renal disease--what can be learned from the Okinawa experience
    Kunitoshi Iseki
    Nephrol Dial Transplant 21:839-43. 2006
  87. ncbi request reprint Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney disease
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 11:41-50. 2007
    ..In the present study, the equations originally developed for a Caucasian population were tested in Japanese CKD patients, and modified with the Japanese coefficient determined by the data...
  88. ncbi request reprint Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 11:156-63. 2007
    ..However, to date, a nationwide epidemiological study has not been conducted yet to survey the CKD population...
  89. ncbi request reprint Kidney disease screening program in Japan: history, outcome, and perspectives
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin J Am Soc Nephrol 2:1360-6. 2007
    ....
  90. ncbi request reprint Modification of the Modification of Diet in Renal Disease (MDRD) Study equation for Japan
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Japan
    Am J Kidney Dis 50:927-37. 2007
    ..The Modification of Diet in Renal Disease (MDRD) Study equation was developed in whites and African Americans, but performance was not evaluated in Japanese...
  91. ncbi request reprint Significance of coronary artery calcification score (CACS) for the detection of coronary artery disease (CAD) in chronic dialysis patients
    Naoko Fujimoto
    Tokuyama Clinic, and Dialysis Unit, University Hospital of the Ryukyus, Japan
    Clin Chim Acta 367:98-102. 2006
    ..There are few reports on the usefulness of EBCT for the detection of CAD, however, in ESRD patients. We examined the relation between CACS and CAD in ESRD patients...
  92. doi request reprint Chronic kidney disease perspectives in Japan and the importance of urinalysis screening
    Kunihiro Yamagata
    Department of Nephrology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan
    Clin Exp Nephrol 12:1-8. 2008
    ..For an effective screening strategy to reduce the ESRD population in Japanese and Asians, universal screening with the urine dip-stick test for proteinuria could be one solution...
  93. doi request reprint Effects of serum calcium, phosphorous, and intact parathyroid hormone levels on survival in chronic hemodialysis patients in Japan
    Shigeru Nakai
    Fujita Health University School of Medicine, Dengakugakubo 1 98, Kutsukake, Toyoake, Aichi 470 1192, Japan
    Ther Apher Dial 12:49-54. 2008
    ..Results showed that disturbances in bone mineral metabolism, such as those involving serum calcium, phosphorous, and iPTH, have a significant impact on survival in Japanese dialysis patients...
  94. ncbi request reprint Association between heart rate and multiple risk factor syndrome: cross-sectional analysis of a screened cohort in Okinawa, Japan
    Taku Inoue
    Cardiovascular Division, Heart Life Hospital
    Circ J 72:454-7. 2008
    ..Increased heart rate (HR) and metabolic syndrome are risk factors for cardiovascular morbidity and mortality, but their relationship has not been studied in a large, screened cohort...
  95. doi request reprint Slower decline of glomerular filtration rate in the Japanese general population: a longitudinal 10-year follow-up study
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 31:433-41. 2008
    ..Hypertension, proteinuria and lower GFR were found to be significant risk factors for a faster decline of GFR...
  96. ncbi request reprint Trends in incidence of end-stage renal disease in Japan, 1983-2000: age-adjusted and age-specific rates by gender and cause
    Kenji Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Nephrol Dial Transplant 19:2044-52. 2004
    ..Trends in age-adjusted or age-specific incidence rates of end-stage renal disease (ESRD) have never been examined in Japan, a major ESRD epidemic area...