Yusuke Inoue

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint [Evaluation of disease model mice using in vivo imaging technologies]
    Yusuke Inoue
    Rinsho Ketsueki 49:437-44. 2008
  2. pmc Timing of imaging after d-luciferin injection affects the longitudinal assessment of tumor growth using in vivo bioluminescence imaging
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int J Biomed Imaging 2010:471408. 2010
  3. ncbi request reprint Breast parenchymal activity on scintimammography: comparison between bone-seeking agents and 99mTc-sestamibi
    Y Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, Japan
    Ann Nucl Med 13:453-6. 1999
  4. doi request reprint Bioluminescent evaluation of the therapeutic effects of total body irradiation in a murine hematological malignancy model
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Exp Hematol 36:1634-41. 2008
  5. ncbi request reprint Monitoring of disease progression by bioluminescence imaging and magnetic resonance imaging in an animal model of hematologic malignancy
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Exp Hematol 35:407-15. 2007
  6. ncbi request reprint Physical characteristics of low and medium energy collimators for 123I imaging and simultaneous dual-isotope imaging
    Y Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, Japan
    Nucl Med Commun 24:1195-202. 2003
  7. ncbi request reprint Effect of collimator choice on quantitative assessment of cardiac iodine 123 MIBG uptake
    Yusuke Inoue
    Department of Radiology, Institute of Medical Sciences, University of Tokyo, Japan
    J Nucl Cardiol 10:623-32. 2003
  8. ncbi request reprint In vitro validation of bioluminescent monitoring of disease progression and therapeutic response in leukaemia model animals
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Eur J Nucl Med Mol Imaging 33:557-65. 2006
  9. ncbi request reprint In vivo fluorescence imaging of the reticuloendothelial system using quantum dots in combination with bioluminescent tumour monitoring
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Eur J Nucl Med Mol Imaging 34:2048-56. 2007
  10. ncbi request reprint Prolonged renal parenchymal retention of 99mTc mercaptoacetyltriglycine after nephron-sparing surgery
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, Graduate School of Medicine, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nucl Med Commun 25:509-13. 2004

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint [Evaluation of disease model mice using in vivo imaging technologies]
    Yusuke Inoue
    Rinsho Ketsueki 49:437-44. 2008
  2. pmc Timing of imaging after d-luciferin injection affects the longitudinal assessment of tumor growth using in vivo bioluminescence imaging
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int J Biomed Imaging 2010:471408. 2010
    ..The time course of the signals after D-luciferin injection may vary with time after cell inoculation, and this variation should be considered when determining the imaging protocol for quantitative bioluminescence tumor monitoring...
  3. ncbi request reprint Breast parenchymal activity on scintimammography: comparison between bone-seeking agents and 99mTc-sestamibi
    Y Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, Japan
    Ann Nucl Med 13:453-6. 1999
    ..Low parenchymal activity is suggested to be a favorable characteristic of 99mTc-MIBI as a scintimammographic agent...
  4. doi request reprint Bioluminescent evaluation of the therapeutic effects of total body irradiation in a murine hematological malignancy model
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Exp Hematol 36:1634-41. 2008
    ..We investigated the utility of in vivo bioluminescence imaging (BLI) in assessing the therapeutic effects of total body irradiation (TBI) in a murine hematological malignancy model...
  5. ncbi request reprint Monitoring of disease progression by bioluminescence imaging and magnetic resonance imaging in an animal model of hematologic malignancy
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Exp Hematol 35:407-15. 2007
    ..We aimed to examine the feasibility and capability of BLI and MRI and to establish techniques for quantitative assessment of disease severity...
  6. ncbi request reprint Physical characteristics of low and medium energy collimators for 123I imaging and simultaneous dual-isotope imaging
    Y Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, Japan
    Nucl Med Commun 24:1195-202. 2003
    ..The SLEHR collimator may be suitable for use in high resolution 123I imaging and simultaneous 99mTc/201Tl imaging. Use of the medium energy collimator appears to be preferable in quantitative 123I studies...
  7. ncbi request reprint Effect of collimator choice on quantitative assessment of cardiac iodine 123 MIBG uptake
    Yusuke Inoue
    Department of Radiology, Institute of Medical Sciences, University of Tokyo, Japan
    J Nucl Cardiol 10:623-32. 2003
    ..Quantitative accuracy in iodine 123 studies may be impaired by septal penetration. We evaluated the effect of collimator choice on estimation of the heart-to-mediastinum (H/M) ratio in cardiac I-123 metaiodobenzylguanidine (MIBG) imaging...
  8. ncbi request reprint In vitro validation of bioluminescent monitoring of disease progression and therapeutic response in leukaemia model animals
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Eur J Nucl Med Mol Imaging 33:557-65. 2006
    ..We conducted cell culture studies to investigate the relationship between bioluminescent signal intensity and viable cell numbers in murine leukaemia model cells...
  9. ncbi request reprint In vivo fluorescence imaging of the reticuloendothelial system using quantum dots in combination with bioluminescent tumour monitoring
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Eur J Nucl Med Mol Imaging 34:2048-56. 2007
    ..We characterised in vivo fluorescence imaging (FLI) of the reticuloendothelial system using quantum dots (QD) and investigated its use in combination with in vivo bioluminescence imaging (BLI)...
  10. ncbi request reprint Prolonged renal parenchymal retention of 99mTc mercaptoacetyltriglycine after nephron-sparing surgery
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, Graduate School of Medicine, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nucl Med Commun 25:509-13. 2004
    ..The aim of this study was to determine whether or not parenchymal retention of Tc-MAG3 is prolonged after nephron-sparing surgery...
  11. ncbi request reprint Effect of temporal resolution on the estimation of left ventricular function by cardiac MR imaging
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Magn Reson Imaging 23:641-5. 2005
    ..In conclusion, low true temporal resolution causes overestimation of ESV and underestimation of EF. Improvement of apparent temporal resolution mildly reduces but does not eliminate the errors caused by low true temporal resolution...
  12. ncbi request reprint Collimator choice in cardiac SPECT with I-123-labeled tracers
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, Japan
    J Nucl Cardiol 11:433-9. 2004
    ..We investigated the impact of collimator choice on cardiac SPECT with I-123...
  13. ncbi request reprint Gadobenate dimeglumine as a contrast agent for MRI of the mouse liver
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    NMR Biomed 20:726-32. 2007
    ..The possible influence of anesthesia on the pharmacokinetics of a contrast agent should be considered in determining the optimal scan timing...
  14. ncbi request reprint Imaging living mice using a 1-T compact MRI system
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Magn Reson Imaging 24:901-7. 2006
    ..To determine the feasibility of imaging living mice with a 1-T compact MRI system and investigate appropriate imaging techniques for use in routine animal experiments...
  15. ncbi request reprint Estimation of 99mTc-MAG3 clearance by single-sample methods and camera-based methods
    Y Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, Japan
    Ann Nucl Med 14:329-32. 2000
    ..The camera-based methods obtained in this study appear to facilitate comparison of results obtained by the Russell method and camera-based method...
  16. ncbi request reprint Diet and abdominal autofluorescence detected by in vivo fluorescence imaging of living mice
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Mol Imaging 7:21-7. 2008
    ..The use of a low-fluorescence diet, especially a purified diet, rapidly reduces intestinal autofluorescence and is expected to enhance the potential of in vivo FLI...
  17. ncbi request reprint Integrated imaging approach to tumor model mice using bioluminescence imaging and magnetic resonance imaging
    Yusuke Inoue
    Department of Radiology and Division of Molecular Therapy, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    Mol Imaging 9:163-72. 2010
    ..Integrated BLI-MRI is feasible and appears to be a practical method for comprehensive, longitudinal assessment of disease model mice...
  18. doi request reprint Fluorescence lymph node mapping in living mice using quantum dots and a compression technique
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Fluoresc 20:599-606. 2010
    ..Fluorescence lymph node mapping using quantum dots allowed the visualization of deep abdominal lymph nodes in addition to superficial nodes in intact mice, with the aid of a simple compression technique...
  19. doi request reprint Gaussia luciferase for bioluminescence tumor monitoring in comparison with firefly luciferase
    Yusuke Inoue
    Department ofDiagnostic Radiology, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa, Japan
    Mol Imaging 10:377-85. 2011
    ..The Gluc blood assay appears to provide a reliable indicator of viable tumor burden, and the combination of a blood assay and in vivo BLI using Gluc should be promising for quantifying and localizing the tumors...
  20. doi request reprint Comparison of subcutaneous and intraperitoneal injection of D-luciferin for in vivo bioluminescence imaging
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Eur J Nucl Med Mol Imaging 36:771-9. 2009
    ..We compared subcutaneous (SC) injection and intraperitoneal (IP) injection of D-luciferin for in vivo bioluminescence imaging (BLI) to determine the utility of SC injection...
  21. doi request reprint Integrated lymphography using fluorescence imaging and magnetic resonance imaging in intact mice
    Yusuke Inoue
    Department of Radiology, Institure of Medical Science, University of Tokyo, Shirokanedai, Minato ku, Japan
    Mol Imaging 10:317-26. 2011
    ..Integrated FLI/MRI lymphography with image fusion appears to be a useful tool for analysis of the murine lymphatic system...
  22. doi request reprint Evaluation of gadoxetate disodium as a contrast agent for mouse liver imaging: comparison with gadobenate dimeglumine
    Shigeru Kiryu
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Magn Reson Imaging 27:101-7. 2009
    ..The contrast effects vary between conscious mice and anesthetized mice and among anesthetic agents used...
  23. ncbi request reprint Interstitial MR lymphography in mice: comparative study with gadofluorine 8, gadofluorine M, and gadofluorine P
    Shigeru Kiryu
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Magn Reson Med Sci 11:99-107. 2012
    ..We investigated the characteristics and capability of interstitial MR lymphography in mice using gadofluorine 8, gadofluorine M, and gadofluorine P...
  24. ncbi request reprint Myocardial glucose utilisation in type II diabetes mellitus patients treated with sulphonylurea drugs
    Ikuo Yokoyama
    Department of Cardiovascular Medicine, Sanno Hospital, International University of Health and Welfare, 8 10 16 Akasaka, Minato ku, Tokyo, 107 0052, Japan
    Eur J Nucl Med Mol Imaging 33:703-8. 2006
    ..The aim of this study was to investigate whether the chronic use of sulphonylurea drugs influences PET measurement of myocardial glucose utilisation (MGU) in type II diabetes mellitus...
  25. ncbi request reprint Results of animal experiments with the fourth model of the undulation pump total artificial heart
    Yusuke Abe
    Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Artif Organs 35:781-90. 2011
    ..However, liver and kidney functions were almost normal, and the total protein level recovered. Further study to stabilize the 1/R control in the UPTAH is necessary...
  26. doi request reprint Diet and gastrointestinal signal on T1-weighted magnetic resonance imaging of mice
    Shigeru Kiryu
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Magn Reson Imaging 28:273-80. 2010
    ..Appropriate dietary preparations facilitate the display of target structures on MIP images and are expected to enhance the capabilities of small animal MR imaging...
  27. doi request reprint The role of the right anterior insular cortex in the right hemisphere preponderance of stimulus-preceding negativity (SPN): an fMRI study
    Yasunori Kotani
    Department of Human System Science, Tokyo Institute of Technology, Tokyo, Japan
    Neurosci Lett 450:75-9. 2009
    ..Because the right anterior insula is related to awareness of viscerosensory information, the SPN right hemisphere preponderance might itself be related to the awareness of interoceptive information that precedes feedback stimuli...
  28. ncbi request reprint Measurement of skeletal muscle glucose utilization by dynamic 18F-FDG PET without arterial blood sampling
    Ikuo Yokoyama
    Department of Cardiovascular Medicine, Sanno Hospital, International University of Health and Welfare, Akasaka, Tokyo, Japan
    Nucl Med Commun 26:31-7. 2005
    ..The aim of this study was to determine whether femoral muscle SMGU can be measured without arterial blood sampling by sequential PET imaging of the thoracic and femoral regions...
  29. ncbi request reprint Development of normal-suction boundary control method based on inflow cannula pressure waveform for the undulation pump ventricular assist device
    Kohei Ishii
    Department of Biomedical Engineering, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Artif Organs 36:812-6. 2012
    ..We defined this ratio as the number of suction occurrences divided by the number of heartbeats. The suction ratio decreased by 70% when the normal-suction boundary control method was used...
  30. ncbi request reprint Contrast-enhanced MR angiography in rats with hepatobiliary contrast agents
    Kohki Yoshikawa
    Department of Radiotechnical Sciences, Faculty of Radiological Health Sciences, Komazawa University, Tokyo, Japan
    Magn Reson Imaging 22:937-42. 2004
    ..These hepatobiliary agents may make it possible to perform contrast-enhanced MR angiography even at a low injection dose...
  31. doi request reprint Long-term assessment of contrast effects of gadofluorine M and gadofluorine P in magnetic resonance imaging of mice
    Fugeng Sheng
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Jpn J Radiol 30:86-91. 2012
    ..To investigate the long-term time course of the contrast effects after the intravenous injection of gadofluorine M or gadofluorine P in mice...
  32. doi request reprint Distortion correction in whole-body imaging of live mice using a 1-Tesla compact magnetic resonance imaging system
    Shigeru Kiryu
    Department of Radiology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Jpn J Radiol 29:353-60. 2011
    ..The aim of this study was to establish a distortion correction applicable to whole-body imaging of live mice...
  33. ncbi request reprint Light emission requires exposure to the atmosphere in ex vivo bioluminescence imaging
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, Japan
    Mol Imaging 5:53-6. 2006
    ..In conclusion, in ex vivo BLI, light emission requires exposure to the atmosphere. Bone destruction is required to demonstrate luciferase activity in the bone marrow after death...
  34. doi request reprint Automatic calibration of the inlet pressure sensor for the implantable continuous-flow ventricular assist device
    Wei Shi
    Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Artif Organs 14:81-8. 2011
    ..The influence of the respiratory change and other factors as well as the reliability of the calibration value should be investigated with an animal experiment as a next step...
  35. doi request reprint The helical flow pump with a hydrodynamic levitation impeller
    Yusuke Abe
    Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    J Artif Organs 15:331-40. 2012
    ..In the second experiment, a white thrombus was found in the pump after 23 days of pumping. While further research and development are necessary, we are expecting to develop an excellent TAH with the HFP...
  36. ncbi request reprint Gallium-67 demonstration of extensive soft-tissue involvement of multiple myeloma
    Makoto Hosono
    Department of Radiology, Saitama Medical Center, Saitama Medical School, Kawagoe, Japan
    Ann Nucl Med 17:69-72. 2003
    ..Although Ga-67 scintigraphy is generally considered of limited value in multiple myeloma, this modality contributed to the development of an appropriate strategy in this patient with extensive extramedullary involvement...
  37. ncbi request reprint Spontaneous regression of chest wall malignant lymphoma. Presentation on Ga-67 imaging
    Kikuo Machida
    Department of Radiology, Saitama Medical Center, Saitama Medical School, Japan
    Clin Nucl Med 28:405-7. 2003
  38. doi request reprint Acquisition protocols and correction methods for estimation of the heart-to-mediastinum ratio in 123I-metaiodobenzylguanidine cardiac sympathetic imaging
    Yusuke Inoue
    Department of Diagnostic Radiology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    J Nucl Med 54:707-13. 2013
    ..We investigated acquisition protocols (collimator choice and energy window setting) and correction methods for estimating the heart-to-mediastinum (H/M) ratio in cardiac (123)I-metaiodobenzylguanidine (MIBG) imaging...
  39. doi request reprint Motion artifact reduction of diffusion-weighted MRI of the liver: use of velocity-compensated diffusion gradients combined with tetrahedral gradients
    Masanori Ozaki
    School of Allied Health Sciences, Kitasato University, Kanagawa, Japan
    J Magn Reson Imaging 37:172-8. 2013
    ....
  40. doi request reprint Diffusion-weighted imaging of local recurrent prostate cancer after radiation therapy: comparison with 22-core three-dimensional prostate mapping biopsy
    Toshimasa Hara
    Department of Diagnostic Radiology, Kitasato University School of Medicine, Kanagawa, Japan
    Magn Reson Imaging 30:1091-8. 2012
    ..In conclusion, DWI is a useful tool for the detection and localization of recurrent prostate cancer in patients with biochemical failure after radiation therapy and may be helpful in the planning of focal salvage therapy...
  41. doi request reprint Effect of isoflurane anesthesia and hypothermia on the hepatic kinetics of Gd-EOB-DTPA: evaluation using MRI of conscious mice
    Shigeru Kiryu
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Magn Reson Imaging 34:354-60. 2011
    ..To develop a method for body magnetic resonance imaging (MRI) of conscious mice and investigate the effect of isoflurane anesthesia and hypothermia on the hepatic kinetics of gadoxetate disodium (Gd-EOB-DTPA)...
  42. ncbi request reprint Evaluation of left ventricular function with cardiac magnetic resonance imaging using Fourier fitting
    Yukihiro Nomura
    Department of Radiology, Institute of Medical Science, University of Tokyo, and Department of Cardiovascular Medicine, Sanno Hospital, Tokyo 108 8639, Japan
    Magn Reson Imaging 24:1333-9. 2006
    ....
  43. ncbi request reprint Effects of monetary reward and punishment on stimulus-preceding negativity
    Yoshimi Ohgami
    Department of Human System Science, Tokyo Institute of Technology, Meguro, Tokyo, Japan
    Psychophysiology 43:227-36. 2006
    ..These results suggest that the SPN is affected by positive emotion: The left hemisphere activation might represent a pleasant emotion accompanying monetary gain...
  44. doi request reprint Lymph drainage from the mammary glands in mice: a magnetic resonance lymphographic study with gadofluorine M
    Fugeng Sheng
    Department of Radiology, Institute of Medical Science, University of Tokyo, Japan
    Acad Radiol 18:512-7. 2011
    ..We aimed to determine the capability of magnetic resonance (MR) lymphography using gadofluorine M and to demonstrate normal lymph drainage from the mammary glands in mice...
  45. doi request reprint Interstitial MR lymphography in mice with gadopentetate dimeglumine and gadoxetate disodium
    Fugeng Sheng
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Magn Reson Imaging 33:490-7. 2011
    ..To investigate the utility of interstitial MR lymphography with gadopentetate dimeglumine (Gd-DTPA) or gadoxetate disodium (Gd-EOB-DTPA) in mice...
  46. ncbi request reprint Phantom and animal studies of a new hepatobiliary agent for MR imaging: comparison of Gd-DTPA-DeA with Gd-EOB-DTPA
    Kohki Yoshikawa
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Magn Reson Imaging 18:204-9. 2003
    ..To investigate the characteristics of Gd-DTPA-DeA as a hepatobiliary contrast agent for MR imaging in comparison with those of Gd-EOB-DTPA...
  47. ncbi request reprint An improved method for estimating the heart-to-mediastinum ratio from cardiac sympathetic nerve imaging with low-energy high-resolution collimators
    Yusuke Inoue
    Department of Diagnostic Radiology, Kitasato University School of Medicine, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa, 252 0374, Japan
    J Nucl Cardiol 21:614-21. 2014
    ..We aimed to improve the method of estimating the H/M ratios using the LEHR collimator...
  48. doi request reprint Computational fluid dynamics analysis of the pump parameters in the helical flow pump
    Kyohei Hosoda
    Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    J Artif Organs 17:9-15. 2014
    ..5 and 2 times the vane width. Although further study is necessary to determine the best values for these parameters, the characteristics of the pump parameters in the HFP could be approximately clarified. ..
  49. pmc Improved reproducibility of simple quantitative indices from ⁹⁹mTc-GSA liver functional imaging
    Gou Ogasawara
    Department of Diagnostic Radiology, Kitasato University School of Medicine, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa 252 0374, Japan
    Ann Nucl Med 27:487-91. 2013
    ....
  50. ncbi request reprint Correlation between left ventricular diastolic function and ejection fraction in dilated cardiomyopathy using magnetic resonance imaging with late gadolinium enhancement
    Shuji Nanjo
    Division of Cardiovascular Medicine, Department of Internal Medicine, Toho University Omori Medical Center, Tokyo, Japan
    Circ J 73:1939-44. 2009
    ..Then the relation with the LV ejection fraction (EF) and deceleration time (DT), an index of diastolic function obtained using echocardiography, was investigated...
  51. ncbi request reprint Three-dimensional stereotactic surface projection of brain perfusion SPECT improves diagnosis of Alzheimer's disease
    Norinari Honda
    Department of Radiology, Saitama Medical Center, Saitama Medical School, Kawagoe, Japan
    Ann Nucl Med 17:641-8. 2003
    ..Alzheimer's disease (AD) is diagnosed by either inspection of the brain perfusion SPECT, or three-dimensional stereotactic surface display (3D-SSP). The purpose was to compare diagnostic performances of these methods...
  52. doi request reprint Quantitative effect of reducing body thickness on visualizing murine deep abdominal lymph nodes by in vivo fluorescence reflectance imaging
    Yusuke Inoue
    Department of Diagnostic Radiology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 252 0374, Japan
    J Fluoresc 21:1325-9. 2011
    ..Overlying tissues profoundly affect signals from a deep source in fluorescence reflectance imaging. Our simple compression method may contribute to quantitatively assessing deep fluorescent sources...
  53. ncbi request reprint Simple quantification of skeletal muscle glucose utilization by static 18F-FDG PET
    Ikuo Yokoyama
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Nucl Med 44:1592-8. 2003
    ..The aim of this study was to determine the validity of simple methods to quantify SMGU by static PET imaging...
  54. doi request reprint Silent white matter lesion in linear scleroderma en coup de sabre
    Mio Sakai
    Department of Radiology, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Comput Assist Tomogr 32:822-4. 2008
    ..Our observation is consistent with vasculopathy and may be helpful in the proper diagnosis and treatment of linear scleroderma en coup de sabre...
  55. ncbi request reprint Introducer needles of peripheral intravenous catheters: assessment of magnetic field interactions with 1.5T and 3T MR systems
    Mio Sakai
    Department of Radiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Magn Reson Med Sci 8:181-5. 2009
    ..From an MR safety standpoint, the SUS 304 should not be selected, and though inconel 600 is the preferred material, the SUS 316L introducer may be more practical with some modifications...
  56. doi request reprint Use of an oral effervescent agent in the evaluation of gastric 67Ga uptake
    Takeshi Yamada
    Department of Diagnostic Radiology, Kitasato University School of Medicine, Minami Ku, Sagamihara, Kanagawa, Japan
    Ann Nucl Med 26:192-6. 2012
    ..The aim of this study was to investigate whether the use of an effervescent agent aids in evaluating gastric (67)Ga uptake...
  57. ncbi request reprint Impaired myocardial vasodilatation during hyperaemic stress is improved by simvastatin but not by pravastatin in patients with hypercholesterolaemia
    Ikuo Yokoyama
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Eur Heart J 25:671-9. 2004
    ..This study investigated whether two commonly used hydroxymethylglutaryl coenzyme A reductase inhibitors, simvastatin and pravastatin, are equally effective in restoring myocardial vasodilatation...
  58. ncbi request reprint Preserved function of the Oddi sphincter after endoscopic papillary balloon dilation
    Hiroyuki Isayama
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hepatogastroenterology 50:1787-91. 2003
    ..However, little is known about the function of Oddi muscle after EPBD. The aim of the present study is to evaluate Oddi muscle function using quantitative cholescintigraphy...
  59. doi request reprint Follow-up magnetic resonance imaging findings in patients with progressive multifocal leukoencephalopathy: evaluation of long-term survivors under highly active antiretroviral therapy
    Mio Sakai
    Department of Radiology, Osaka University Graduate School of Medicine, 565 0871, Japan
    Jpn J Radiol 27:69-77. 2009
    ....
  60. doi request reprint Septal penetration in iodine-123 metaiodobenzylguanidine cardiac sympathetic imaging using a medium-energy collimator
    Yusuke Inoue
    Department of Diagnostic Radiology, Kitasato University School of Medicine, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa, 252 0374, Japan
    J Nucl Cardiol 21:71-7. 2014
    ..We investigated the effect of septal penetration on the estimation of H/M ratios using an ME collimator...
  61. doi request reprint Estimation of Tc-99m MAG3 clearance using camera-based methods without blood sampling
    Yusuke Inoue
    Department of Diagnostic Radiology, Kitasato University School of Medicine, Sagamihara, Japan
    Clin Nucl Med 36:1012-6. 2011
    ..To establish camera-based methods for estimating Tc-99m mercaptoacetyltriglycine (MAG3) clearance without blood sampling...
  62. ncbi request reprint Results of a phase I clinical study using dendritic cell vaccinations for thyroid cancer
    Koichiro Kuwabara
    Department of Advanced Medical Science, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Thyroid 17:53-8. 2007
    ..We assessed the feasibility and efficacy of dendritic cell (DC) therapy for advanced thyroid papillary and follicular cancer...
  63. ncbi request reprint Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells
    Atsuko Miura
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:5246-57. 2006
    ..Because the K(ATP) channel is important for proper insulin secretion in beta-cells, altered K(ATP) channel activity could be related to the impaired insulin secretion in the betaHNF-4alphaKO mice...
  64. doi request reprint Free-breathing diffusion-weighted imaging for the assessment of inflammatory activity in Crohn's disease
    Shigeru Kiryu
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Magn Reson Imaging 29:880-6. 2009
    ..To investigate the application of free-breathing diffusion-weighted MR imaging (DWI) to the assessment of disease activity in Crohn's disease...
  65. ncbi request reprint Delayed enhancement of pelvic lymphangiomyoma associated with lymphangioleiomyomatosis on MR imaging (2005: 9b)
    Eriko Maeda
    Department of Radiology, Graduate School of Medicine, University of Tokyo, Japan
    Eur Radiol 15:2528-31. 2005
  66. ncbi request reprint Biliary motor function in gallstone patients evaluated by fatty-meal MR cholangiography
    Yusuke Inoue
    Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Magn Reson Imaging 18:196-203. 2003
    ..To investigate the possibility of evaluating biliary motor function with magnetic resonance cholangiography (MRC)...
  67. doi request reprint Impact of the integrin signaling adaptor protein NEDD9 on prognosis and metastatic behavior of human lung cancer
    Shunsuke Kondo
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Clin Cancer Res 18:6326-38. 2012
    ..In the present study, we aimed at elucidating a role of NEDD9 in the signaling crosstalk between EGFR and integrins...
  68. pmc Imaging findings of pelvic tumor thrombosis extending from sacral bone metastasis of adrenocortical carcinoma
    Kenichiro Ishida
    Department of Diagnostic Radiology, Kitasato University School of Medicine, 1 15 1 Kitasato, Minami Ku, Sagamihara, Kanagawa 252 0373, Japan
    Case Rep Radiol 2012:919603. 2012
    ..Multimodality imaging may be beneficial for the characterization and localization of lesions in patients suspected of having metastatic adrenocortical carcinoma...
  69. doi request reprint Diffusion-weighted imaging of the breast: principles and clinical applications
    Reiko Woodhams
    Department of Diagnostic Radiology, Kitasato University School of Medicine, Minamiku, Kanagawa, Japan
    Radiographics 31:1059-84. 2011
    ..Standardization of diffusion-weighted imaging parameters is needed to allow comparison of multicenter studies and assessment of the clinical utility of diffusion-weighted imaging and ADC values in breast evaluation...
  70. ncbi request reprint Preliminary study of physiological control for the undulation pump ventricular assist device
    Itsuro Saito
    Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, Japan
    Conf Proc IEEE Eng Med Biol Soc 2010:5218-21. 2010
    ..The assist flow could be increased more than 15% and the inflow sucking occurrence could be decreased with this control method. The UPVAD could generate the suitable assist flow with the developed control method...
  71. pmc Phase I clinical trial of the vaccination for the patients with metastatic melanoma using gp100-derived epitope peptide restricted to HLA-A*2402
    Toshiyuki Baba
    Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokane dai, Minato city, Tokyo, 108 8639, Japan
    J Transl Med 8:84. 2010
    ..Since it is the most common HLA Class I allele in the Japanese population, we performed a phase I clinical trial of cancer vaccination using the HLA-A*2402 gp100 peptide to treat patients with metastatic melanoma...
  72. ncbi request reprint Reduced myocardial flow reserve in anatomically normal coronary arteries due to elevated baseline myocardial blood flow in men with old myocardial infarction
    Katsunori Yonekura
    Department of Cardiovascular Medicine, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
    J Nucl Cardiol 9:62-7. 2002
    ..Decreased myocardial flow reserve (MFR) in angiographically normal coronary arteries in patients with old myocardial infarction (OMI) has been reported...
  73. ncbi request reprint Different mechanisms involved in interhemispheric transfer of visuomotor information
    Kazufumi Omura
    Department of Radiology, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Neuroreport 15:2707-11. 2004
    ..Our results suggested that CUD depended on the interhemispheric transfer via the CC, and that CUD and redundancy gain involved different brain mechanisms...
  74. ncbi request reprint Age dependence of diffusion-weighted magnetic resonance imaging findings in maple syrup urine disease encephalopathy
    Mio Sakai
    Department of Radiology, Osaka National Hospital, Osaka 540 0006, Japan
    J Comput Assist Tomogr 29:524-7. 2005
    ..Our observation demonstrates the age dependence of DW imaging findings in MSUD encephalopathy attributable to progression of myelination and would help in the proper diagnosis of MSUD encephalopathy at any age...
  75. ncbi request reprint Phase I study of autologous tumor vaccines transduced with the GM-CSF gene in four patients with stage IV renal cell cancer in Japan: clinical and immunological findings
    Kenzaburo Tani
    Advanced Clinical Research Center, The Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Mol Ther 10:799-816. 2004
    ..Our results suggest that GVAX substantially enhanced the antitumor cellular and humoral immune responses, which might have contributed to the relatively long survival times of our patients in the present study...
  76. doi request reprint The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line
    Harukazu Suzuki
    RIKEN Omics Science Center, RIKEN Yokohama Institute, Kanagawa, Japan
    Nat Genet 41:553-62. 2009
    ....
  77. pmc Physicians' recommendations to their patients concerning a novel pandemic vaccine: a cross-sectional survey of the 2009 influenza A/H1N1 pandemic in Japan
    Yusuke Inoue
    Department of Public Policy, Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato ku, Japan
    Environ Health Prev Med 16:320-6. 2011
    ..We aimed to elucidate physicians' attitudes regarding the novel vaccine during the influenza A/H1N1 pandemic of 2009, and to determine factors that affected their vaccination recommendations to patients...
  78. doi request reprint Relative and absolute stereochemistry of quinadoline B, an inhibitor of lipid droplet synthesis in macrophages
    Nobuhiro Koyama
    School of Pharmacy, Kitasato University, Tokyo, Japan
    Org Lett 10:5273-6. 2008
    ..The complete relative and absolute stereochemistry of 2 was determined by X-ray crystallography and amino acid analysis using a chiral column. Quinadolines moderately inhibited lipid droplet synthesis in mouse macrophages...
  79. ncbi request reprint The effect of dimethyl sulfoxide on the function of cytochrome P450 2D6 in HepG2 cells upon the co-expression with NADPH-cytochrome P450 reductase
    Shizuo Narimatsu
    Laboratory of Health Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Chem Biol Interact 159:47-57. 2006
    ..The HepG2 cell lines stably expressing OR and CYP2D6 or its variants in combination with DMSO treatment may be useful for screening the cytotoxicity of chemical compounds which undergo oxidation by CYP2D6...
  80. ncbi request reprint Scintigraphic findings of MALT lymphoma of the thyroid
    Norinari Honda
    Department of Radiology, Saitama Medical Center, Saitama Medical School, Kawagoe, Japan
    Ann Nucl Med 16:289-92. 2002
    ..After radiotherapy, abnormally increased uptake disappeared on 67Ga images, which predicted a favorable outcome. MALT lymphoma of the thyroid may be visualized as a warm nodule on 99mTc pertechnetate scintigraphy...
  81. ncbi request reprint [Evaluation of imaging parameters for T1 dynamic contrast enhanced MRI with fast spin-echo]
    Yuuki Kanazawa
    Department of Radiology, Kyoto First Red Cross Hospital
    Nihon Hoshasen Gijutsu Gakkai Zasshi 63:1127-32. 2007
    ..This method using TSE is able to evaluate in greater detail information on hemodynamics and to perform dynamic study with the spin-echo sequence in extensive tissues...
  82. ncbi request reprint Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4alpha
    Olivier Barbier
    Unité INSERM 545, Institut Pasteur de Lille, 1 rue du Pr Calmette, BP 245, 59019 Lille, France
    Mol Pharmacol 67:241-9. 2005
    ....
  83. ncbi request reprint Interstitial magnetic resonance lymphography: comparative animal study of gadofluorine 8 and gadolinium diethylenetriamine-pentaacetic acid
    Morio Shimada
    1st Department of Radiology, Toho University School of Medicine, Omorinishi 5 21 16, Otaku, Tokyo 143 8540, Japan
    J Comput Assist Tomogr 27:641-6. 2003
    ..We evaluated the usefulness of gadofluorine 8 (G8) and gadolinium diethylenetriamine-pentaacetic acid (Gd-DTPA) for interstitial magnetic resonance lymphography (MRL)...
  84. ncbi request reprint Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis
    Yusuke Inoue
    Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:44740-8. 2004
    ..These data demonstrate that hepatic C/EBPalpha is critical for ammonia detoxification and glucose and lipid homeostasis in adult mice...
  85. ncbi request reprint Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice
    Kimihiko Matsusue
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 18:2751-64. 2004
    ..Taken together, these results indicate that hepatic C/EBP alpha plays a critical role in the acceleration of lipogenesis in ob/ob mice and in glucose homeostasis by the indirect regulation of insulin secretion...
  86. ncbi request reprint Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver
    Akihide Kamiya
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bldg 37, Rm 3106B1, 9000 Rockville Pike, Bethesda, MD 20892, USA
    FEBS Lett 578:63-8. 2004
    ..These results suggested that HNF4alpha and HNF1alpha regulate proline metabolism in adult liver...
  87. ncbi request reprint Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression
    Thierry Claudel
    UR545 INSERM, Departement d Atherosclerose, Institut Pasteur de Lille, Lille, France
    Gastroenterology 125:544-55. 2003
    ..Apolipoprotein CIII (Apo CIII) is a determinant of serum triglyceride metabolism. In this study, we investigated whether activators of the nuclear farnesoid X receptor (FXR) modulate Apo CIII gene expression...
  88. ncbi request reprint Gamma/delta T cell lymphoma
    Akihiko Taguchi
    Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu 747 8511
    Intern Med 43:120-5. 2004
    ....
  89. ncbi request reprint Activation of insular cortex and subcortical regions related to feedback stimuli in a time estimation task: an fMRI study
    Tetsuji Tsukamoto
    Department of Kinesiology, Tokyo Metropolitan University, 1 1 Minamiosawa, Hachioji, Tokyo 192 0397, Japan
    Neurosci Lett 399:39-44. 2006
    ....
  90. ncbi request reprint Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors
    Yuan Zhang
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
    Mol Endocrinol 18:851-62. 2004
    ....
  91. ncbi request reprint Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development
    Akihide Kamiya
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 37:1375-84. 2003
    ..In conclusion, HNF4alpha is the key transcription factor regulating responses to xenobiotics through activation of the PXR gene during fetal liver development...
  92. pmc Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis
    James Rhee
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:4012-7. 2003
    ..These data illustrate the involvement of PGC-1alpha in several aspects of the hepatic fasting response and show that HNF4alpha is a critical component of PGC-1alpha-mediated gluconeogenesis...
  93. ncbi request reprint C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism
    Brice Courselaud
    INSERM U522, CHRU Pontchaillou, 35033 Rennes Cedex, France
    J Biol Chem 277:41163-70. 2002
    ..Taken together, these data demonstrate that C/EBPalpha is likely to be a key regulator of HEPC gene transcription and provide a novel mechanism for cross-talk between the C/EBP pathway and iron metabolism...
  94. ncbi request reprint Development of a bidirectional transcutaneous optical data transmission system for artificial hearts allowing long-distance data communication with low electric power consumption
    Eiji Okamoto
    Department of Information Science, School of Engineering, Hokkaido Tokai University, 5 1 1 1 Minami sawa, Minami Ku, Sapporo, 005 8601, Japan
    J Artif Organs 8:149-53. 2005
    ..From the above results, a bidirectional transcutaneous optical data transmission system promises adequate performance for monitoring and control of an artificial heart...
  95. pmc Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha
    Yusuke Inoue
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 47:215-27. 2006
    ..These studies reveal that HNF4alpha plays a central role in BA homeostasis by regulation of genes involved in BA biosynthesis, including hydroxylation and side chain beta-oxidation of cholesterol in vivo...
  96. ncbi request reprint Development of a miniature motor-driven pulsatile LVAD driven by a fuzzy controller
    Eiji Okamoto
    Department of Information Science, School of Engineering, Hokkaido Tokai University, 5 1 1 1 Minami sawa, Minami Ku, Sapporo 005 8601, Japan
    J Artif Organs 10:158-64. 2007
    ..5%. While the LVAD can provide adequate pump outflow for cardiac assistance, further upgrading of the software and improvement of the blood pump are required to improve pump performance and efficiency...
  97. ncbi request reprint Interaction of anti-aggregation agent dimethylethylammonium propane sulfonate with acidic fibroblast growth factor
    Long Xiang
    Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University, 1 5 1 Tenjin cho, Kiryu, Gunma 376 8515, Japan
    J Magn Reson 194:147-51. 2008
    ..The apparent dissociation constants of the interaction ranged from 0.04 to 3M, indicating weak interactions between NDSB and protein molecules...
  98. ncbi request reprint Resolution of secondary alcohols via Carica papaya lipase-catalyzed enantioselective acylation
    Toshifumi Miyazawa
    Department of Chemistry, Faculty of Science and Engineering, Konan University, Higashinada ku, Kobe 658 8501, Japan
    Biotechnol Lett 30:1783-7. 2008
    ..Thus, this plant lipase proved to be a promising biocatalyst for the resolution of alcohols as well as for that of carboxylic acids reported earlier...
  99. pmc Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease
    Sung Hoon Ahn
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Inflamm Bowel Dis 14:908-20. 2008
    ..While HNF4alpha expression is critical for liver function, its role in the gut and in the pathogenesis of inflammatory bowel disease (IBD) is unknown...
  100. ncbi request reprint Drug binding and releasing characteristics of DNA/lipid/PLGA film
    Tadao Fukushima
    Department of Dental Engineering, Bioengineering Section, Fukuoka Dental College, 2 15 1 Tamura, Sawara ku, Fukuoka 814 0193, Japan
    Dent Mater J 26:854-60. 2007
    ..Released DH caused reduction of cell viability during the cell culture of L929 mouse fibroblasts. These results suggested that DNA/lipid/PLGA film was a promising useful material for DDS...
  101. doi request reprint Evaluation of protein kinase activities of cell lysates using peptide microarrays based on surface plasmon resonance imaging
    Takeshi Mori
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 819 0395, Japan
    Anal Biochem 375:223-31. 2008
    ..Thus, the peptide microarray based on SPR imaging would be applicable to cell-based drug discovery, diagnosis using tissue lysates, and biochemical studies to reveal signal transduction pathways...