Research Topics
Genomes and Genes | J InoueSummaryAffiliation: University of Tokyo Country: Japan Publications
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Publications
Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic regionT Ishida
Department of Oncology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108, Japan
J Biol Chem 271:28745-8. 1996..These results suggest that TRAF6 could mediate the CD40 signal that is transduced by the amino-terminal domain (230-245) of the CD40 cytoplasmic region and appears to be independent of other known TRAF family proteins...
Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40N Tsukamoto
Department of Oncology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Proc Natl Acad Sci U S A 96:1234-9. 1999..These results indicate that NFkappaB activating signals emanating from cyt-N and cyt-C are mediated by the different members of the TRAF family and could be regulated in a distinct manner...- Identification and expression of the Xenopus homolog of mammalian p100-NFkappaB2K Suzuki
Department of Oncology, The Institute of Medical Science, The University of Tokyo, Japan
Gene 206:1-9. 1998..These results suggest that Xp100 could be involved in the late-stage development of Xenopus laevis, especially in the maturation of somites... - Transcriptional regulation of the ATP citrate-lyase gene by sterol regulatory element-binding proteinsR Sato
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
J Biol Chem 275:12497-502. 2000..Therefore, SREBPs transcriptionally regulates ACL enzyme activity, which generates the cytosolic acetyl CoA required for both cholesterol and fatty acid synthesis... - Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activationS Aizawa
Department of Pathology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108, Japan
J Biol Chem 272:2042-5. 1997..Taken together, our results indicate that TRAF2 and TRAF5 directly interact with CD30 and are involved in NFkappaB activation by CD30 signaling... - TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signalingT K Ishida
Department of Oncology, University of Tokyo, Japan
Proc Natl Acad Sci U S A 93:9437-42. 1996..These results suggest that TRAF5 and TRAF3 could be involved in both common and distinct signaling pathways emanating from CD40... - Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient miceA Naito
Department of Oncology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Genes Cells 4:353-62. 1999..However, the functions of TRAF6 in vivo remain unidentified... - A novel zinc finger protein, Finb, is a transcriptional activator and localized in nuclear bodiesA Fujimoto-Nishiyama
Department of Oncology, Institute of Medical Science, University of Tokyo, Japan
Gene 195:267-75. 1997..Further characterization of Finb would unravel an important role of nuclear body-involved transcriptional regulation... - Induction of interleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-kappaBT Yoshimoto
Department of Allergology, The Institute of Medical Science, The University of Tokyo, Japan
Eur J Immunol 27:3461-70. 1997.... - Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindleN Tokai
The Institute of Medical Science, The University of Tokyo, Japan
EMBO J 15:457-67. 1996..Thus, we propose that Kid might play a role(s) in regulating the chromosomal movement along microtubules during mitosis... - Molecular cloning of cDNA encoding the Xenopus homolog of mammalian RelBK Suzuki
Department of Oncology, University of Tokyo, Japan
Nucleic Acids Res 23:4664-9. 1995..These results raise the possibility that XrelB and Xrel1/XrelA play different roles in the development of X.laevis... - A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophagesR Horie
Department of Pathology, University of Tokyo, Japan
Blood 88:2422-32. 1996..These observations provided new insights into the molecular heterogeneity and biological function of CD30 in myeloid cells... - Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genesT Kawai
Department of Host Defense, Research Institute for Microbial Diseases, Japan Science and Technology Corporation, Osaka University, Osaka, Japan
J Immunol 167:5887-94. 2001.... - TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinaseA Hatzoglou
Laboratory of Experimental Endocrinology, Faculty of Medicine, University of Crete, Heraklion, Greece
J Immunol 165:1322-30. 2000.... - The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathwayJ Ninomiya-Tsuji
Department of Molecular Biology, Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation
Nature 398:252-6. 1999..Activated TAK1 phosphorylates NIK, which stimulates IKK-alpha activity. Our results indicate that TAK1 links TRAF6 to the NIK-IKK cascade in the IL-1 signalling pathway... - Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesisN Kobayashi
Department of Hematology, Research Institute, International Medical Center of Japan, Shinjuku ku, Tokyo 162 8655, Japan
EMBO J 20:1271-80. 2001..Thus, TRAF6 plays essential roles in both the differentiation and maturation of osteoclasts by activating various kinases via its multiple domains... - Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)S Mizushima
Biosciences Research Laboratory, Mochida Pharmaceutical Co Ltd, Tokyo, Japan
Gene 207:135-40. 1998..These results suggest that the human TRAF5 protein could be involved in the signal triggered by various members of the tumor necrosis factor receptor (TNFR) superfamily including CD40, CD30 and lymphotoxin-beta receptor... - DNA sequence recognition by NF kappa B p50 homodimer: strict and obscure recognition sites in the binding sequenceA Kittaka
Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199-0195, Japan
Nucleosides Nucleotides Nucleic Acids 20:669-72. 2001..It was found that one thymidine in the kappa B site is particularly important for the sequence specific recognition by NF kappa B... - Loss of cortical and thalamic neuronal tenascin-C expression in a transgenic mouse expressing exon 1 of the human Huntington disease geneM Kusakabe
Division of Experimental Animal Research, RIKEN, Tsukuba, Japan
J Comp Neurol 430:485-500. 2001.... - Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndromeT Shinohara
Department of Molecular and Cell Genetics, School of Life Sciences, Faculty of Medicine, Tottori University and CREST (JST, Nishimachi 86, Yonago, Tottori 683-8503, Japan
Hum Mol Genet 10:1163-75. 2001..These chimeric mice mimic a wide variety of phenotypic traits of DS, revealing the utility of mice containing Chr 21 as unique models for DS and for the identification of genes responsible for DS... - A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitusT Arima
Wellcome CRC Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK
Hum Mol Genet 10:1475-83. 2001..We propose that this ICR regulates expression of imprinted genes within the domain; epigenetic or genetic mutations of this region probably result in TNDM, possibly by affecting expression of ZAC in the pancreas and/or the pituitary... - TAK1 is a ubiquitin-dependent kinase of MKK and IKKC Wang
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
Nature 412:346-51. 2001..We also provide evidence that TRAF6 is conjugated by the K63 polyubiquitin chains. These results indicate that ubiquitination has an important regulatory role in stress response pathways, including those of IKK and JNK... - IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinasesT Shimada
Department of Biochemistry, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
Int Immunol 11:1357-62. 1999..These results suggest that IKK-i is an inducible IkappaB kinase which may play a special role in the immune response... - A novel splicing isoform of mouse sterol regulatory element-binding protein-1 (SREBP-1)J Inoue
Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan
Biosci Biotechnol Biochem 63:243-5. 1999..Although this isoform was not a dominant isoform, it might be possible that the produced protein functions differently from other isoforms including a complete PEST sequence... - I kappa B gamma, a 70 kd protein identical to the C-terminal half of p110 NF-kappa B: a new member of the I kappa B familyJ Inoue
Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186 5800
Cell 68:1109-20. 1992..The 70 kd protein, predominantly found in lymphoid cells, is a new member of the I kappa B family of proteins and is referred to as I kappa B gamma... - Mouse germinal center B cells with the xid mutation retain responsiveness to antimouse CD40 antibodies but diminish IL-5 responsivenessM Baba
Department of Immunology, University of Tokyo, Japan
Int Immunol 9:1463-73. 1997..These results suggest that anti-CD40 mAb, IL-4 and IL-5 play a critical role in the differentiation of mouse GC B cells. The GC B cells from XID mice show a functional defect with respect to IL-5-mediated differentiation... - Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1Y Sowa
Department of Preventive Medicine, Kyoto Prefectural University of Medicine, Kamigyo ku, Japan
Cancer Res 57:3145-8. 1997..As expected, hGABP/E4TF1 enhanced the core RB promoter activity, whereas it did not stimulate a mutant RBF-1 site. We therefore conclude that the most essential transcription factor in the human RB gene is likely to be hGABP/E4TF1... - MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alphaM Hirano
Department of Molecular Biology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236, Japan
J Biol Chem 271:13234-8. 1996..These results suggest that MEK kinase is a signal mediator involved in TNFalpha-induced NF-kappaB activation and that the activation of NF-kappaB by MEK kinase is regulated through the degradation of IkappaB-alpha... - Novel zinc chelators with dual activity in the inhibition of the kappa B site-binding proteins HIV-EP1 and NF-kappa BM Otsuka
Institute for Chemical Research, Kyoto University, Japan
J Med Chem 38:3264-70. 1995..Thus, it became possible to inhibit either one of the two kappa B site-binding proteins without inhibiting the other.(ABSTRACT TRUNCATED AT 250 WORDS).. - c-rel activates but v-rel suppresses transcription from kappa B sitesJ Inoue
Molecular Biology and Virology Laboratory, Salk Institute, San Diego, CA 92186 5800
Proc Natl Acad Sci U S A 88:3715-9. 1991..Thus, v-rel may interfere with the normal transcriptional machinery of the cell by acting as a dominant negative mutant... - POU2AF1, an amplification target at 11q23, promotes growth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor, TNFRSF17C Zhao
Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo, Japan
Oncogene 27:63-75. 2008....