Hiroshi Inoue

Summary

Affiliation: University of Toyama
Country: Japan

Publications

  1. ncbi Canine model of Brugada syndrome using regional epicardial cooling of the right ventricular outflow tract
    Kunihiro Nishida
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Electrophysiol 15:936-41. 2004
  2. ncbi Enalapril preserves sinus node function in a canine atrial fibrillation model induced by rapid atrial pacing
    Masao Sakabe
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Electrophysiol 16:1209-14. 2005
  3. ncbi Thromboembolism in patients with nonvalvular atrial fibrillation: comparison between Asian and Western countries
    Hiroshi Inoue
    Second Department of Internal Medicine, Toyama University Hospital, 2630 Sugitani, Toyama City, Toyama 930 0194, Japan
    J Cardiol 61:1-7. 2013
  4. ncbi Prevalence of atrial fibrillation in the general population of Japan: an analysis based on periodic health examination
    Hiroshi Inoue
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Sugitani, Toyama, Japan
    Int J Cardiol 137:102-7. 2009
  5. ncbi Accumulation of risk factors increases risk of thromboembolic events in patients with nonvalvular atrial fibrillation
    Hiroshi Inoue
    Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    Circ J 70:651-6. 2006
  6. ncbi Sex-related differences in the risk factor profile and medications of patients with atrial fibrillation recruited in J-TRACE
    Hiroshi Inoue
    Department of Internal Medicine, University of Toyama, Toyama, Japan
    Circ J 74:650-4. 2010
  7. ncbi d,l-Sotalol reverses abbreviated atrial refractoriness and prevents promotion of atrial fibrillation in a canine model with left ventricular dysfunction induced by atrial tachypacing
    Tamotsu Sakamoto
    Second Department of Internal Medicine, University of Toyama, Japan
    Circ J 73:1820-8. 2009
  8. ncbi Accumulation of risk factors enhances the prothrombotic state in atrial fibrillation
    Kazumasa Ohara
    Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Int J Cardiol 126:316-21. 2008
  9. ncbi UGT2B7*3 did not affect the pharmacokinetics of R- and S-carvedilol in healthy Japanese
    Mutsuko Honda
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Drug Metab Pharmacokinet 22:382-6. 2007
  10. ncbi D-dimer level influences thromboembolic events in patients with atrial fibrillation
    Takashi Nozawa
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-0194, Nagasaki, Japan
    Int J Cardiol 109:59-65. 2006

Detail Information

Publications120 found, 100 shown here

  1. ncbi Canine model of Brugada syndrome using regional epicardial cooling of the right ventricular outflow tract
    Kunihiro Nishida
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Electrophysiol 15:936-41. 2004
    ..CONCLUSION: Localized epicardial cooling of the RVOT could be an in vivo experimental model of Brugada syndrome...
  2. ncbi Enalapril preserves sinus node function in a canine atrial fibrillation model induced by rapid atrial pacing
    Masao Sakabe
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Electrophysiol 16:1209-14. 2005
    ..CONCLUSIONS: Rapid atrial pacing impaired SN function through IF and AT of the SN. Enalapril prevented these pacing-induced degenerative changes and improved SN function...
  3. ncbi Thromboembolism in patients with nonvalvular atrial fibrillation: comparison between Asian and Western countries
    Hiroshi Inoue
    Second Department of Internal Medicine, Toyama University Hospital, 2630 Sugitani, Toyama City, Toyama 930 0194, Japan
    J Cardiol 61:1-7. 2013
    ..New oral anticoagulants have been launched in Japan as an alternative to warfarin. The management strategy for AF patients needs to be modified based on the data obtained from Japanese patients...
  4. ncbi Prevalence of atrial fibrillation in the general population of Japan: an analysis based on periodic health examination
    Hiroshi Inoue
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Sugitani, Toyama, Japan
    Int J Cardiol 137:102-7. 2009
    ..The age- and gender-specific prevalence rate of atrial fibrillation (AF) in the general population of Japan was determined using the data from periodic health examinations in 2003...
  5. ncbi Accumulation of risk factors increases risk of thromboembolic events in patients with nonvalvular atrial fibrillation
    Hiroshi Inoue
    Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    Circ J 70:651-6. 2006
    ..To validate this hypothesis, a post hoc analysis was performed to determine the relationship of risk levels and thromboembolic events in patients with NVAF from our previous prospective study...
  6. ncbi Sex-related differences in the risk factor profile and medications of patients with atrial fibrillation recruited in J-TRACE
    Hiroshi Inoue
    Department of Internal Medicine, University of Toyama, Toyama, Japan
    Circ J 74:650-4. 2010
    ..Whether such a difference exists for Japanese patients with AF is unclear, so data from J-TRACE were used to investigate this issue...
  7. ncbi d,l-Sotalol reverses abbreviated atrial refractoriness and prevents promotion of atrial fibrillation in a canine model with left ventricular dysfunction induced by atrial tachypacing
    Tamotsu Sakamoto
    Second Department of Internal Medicine, University of Toyama, Japan
    Circ J 73:1820-8. 2009
    ..This study evaluated antiarrhythmic effects of d,l-sotalol in a canine atrial fibrillation (AF) model with left ventricular dysfunction...
  8. ncbi Accumulation of risk factors enhances the prothrombotic state in atrial fibrillation
    Kazumasa Ohara
    Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Int J Cardiol 126:316-21. 2008
    ..The present study was conducted to investigate the relation between the accumulation of the risk factors of thromboembolism and the levels of hemostatic markers in patients with nonvalvular atrial fibrillation (NVAF)...
  9. ncbi UGT2B7*3 did not affect the pharmacokinetics of R- and S-carvedilol in healthy Japanese
    Mutsuko Honda
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Drug Metab Pharmacokinet 22:382-6. 2007
    ....
  10. ncbi D-dimer level influences thromboembolic events in patients with atrial fibrillation
    Takashi Nozawa
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-0194, Nagasaki, Japan
    Int J Cardiol 109:59-65. 2006
    ..CONCLUSIONS: D-dimer level in combination with clinical risk factors could effectively predict subsequent thromboembolic events in patients with NVAF even when treated with warfarin...
  11. ncbi Influence of CYP2D6 genotype on metoprolol plasma concentration and beta-adrenergic inhibition during long-term treatment: a comparison with bisoprolol
    Takashi Nozawa
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Cardiovasc Pharmacol 46:713-20. 2005
    ..In contrast, bisoprolol has a relatively constant beta-adrenergic inhibition independent of CYP2D6 genotype...
  12. ncbi Chronic kidney disease and CHADS(2) score independently predict cardiovascular events and mortality in patients with nonvalvular atrial fibrillation
    Keiko Nakagawa
    Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    Am J Cardiol 107:912-6. 2011
    ..Long-term mortality, cardiac events, and stroke risk were >8 times higher when decreased eGFR (<60 ml/min/1.73 m(2)) was present with higher CHADS(2) score (≥2)...
  13. ncbi Multiple regression analysis of pharmacogenetic variability of carvedilol disposition in 54 healthy Japanese volunteers
    Mutsuko Honda
    Graduate School of Pharmaceutical Sciences, University of Toyama, Sugitani, Japan
    Biol Pharm Bull 29:772-8. 2006
    ..On the other hand, CYP2C9*3, CYP2C19*2, CYP2C19*3, CYP3A5*3, UGT2B7*2, and MDR1 C3435T did not significantly affect the pharmacokinetics of carvedilol in Japanese subjects...
  14. ncbi Supersensitive response to isoproterenol in patients with marked global reduction of cardiac metaiodobenzylguanidine uptake
    Naohiro Yoshida
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Circ J 67:745-9. 2003
    ..4%) and II (2.6+/-1.7 mm and 8.9+/-7.9%). The present results suggest that the sympathetically denervated human heart is supersensitive to IP and the exaggerated responses may be caused, at least in part, by a postsynaptic mechanism...
  15. ncbi Anticoagulation control quality affects the D-dimer levels of atrial fibrillation patients
    Yosuke Nakatani
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Japan
    Circ J 76:317-21. 2012
    ..Anticoagulation control quality affects the incidence of thromboembolic events in atrial fibrillation (AF) patients. However, the effects of anticoagulation control quality on the prothrombotic state of AF patients are unclear...
  16. ncbi Fluvastatin attenuates diabetes-induced cardiac sympathetic neuropathy in association with a decrease in oxidative stress
    Akira Matsuki
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Circ J 74:468-75. 2010
    ..Increased oxidative stress might contribute to diabetic (DM) neuropathy, so the effects of long-term treatment with fluvastatin (FL) on myocardial oxidative stress and cardiac sympathetic neural function were investigated in diabetic rats...
  17. ncbi Thoracic aortic plaque enhances hypercoagulability in patients with nonrheumatic atrial fibrillation
    Keiko Nakagawa
    Second Department of Internal Medicine, University of Toyama, Japan
    Circ J 71:52-6. 2007
    ..The relationship between plasma hemostatic markers and aortic atherosclerosis was determined in patients with AF or in sinus rhythm (SR)...
  18. ncbi Influence of beta-adrenoceptor blockade on the myocardial accumulation of fatty acid tracer and its intracellular metabolism in the heart after ischemia-reperfusion injury
    Norio Igarashi
    Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan
    Circ J 70:1509-14. 2006
    ..The administration of beta-blockade before ischemia could accelerate the recovery from ischemia-reperfusion injury by inhibiting myocardial FA accumulation before beta-oxidation...
  19. ncbi Evaluation of fatty acid metabolism in hearts after ischemia-reperfusion injury using a dual-isotope autoradiographic approach and tissue assay for metabolites of tracer
    Norio Igarashi
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
    J Nucl Med 46:160-4. 2005
    ..CONCLUSION: Normal uptake of fatty acid tracer early after reperfusion does not always imply preserved intracellular fatty acid oxidation. However, reduction of tracer uptake might reflect impaired fatty acid oxidation...
  20. ncbi Repeated sauna therapy attenuates ventricular remodeling after myocardial infarction in rats by increasing coronary vascularity of noninfarcted myocardium
    Mitsuo Sobajima
    The Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Sugitani, Toyama, Japan
    Am J Physiol Heart Circ Physiol 301:H548-54. 2011
    ..In conclusion, ST attenuates cardiac remodeling after MI, at least in part, through improving coronary vascularity in the noninfarcted myocardium. Repeated ST might serve as a novel noninvasive therapy for patients with MI...
  21. ncbi Combination therapy of candesartan with statin inhibits progression of atherosclerosis more than statin alone in patients with coronary artery disease
    Takayuki Suzuki
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Toyama, Japan
    Coron Artery Dis 22:352-8. 2011
    ..However, it remains unclear whether combination therapy of RAS inhibitor with statin could inhibit plaque progression more than statin alone...
  22. ncbi Central sympathetic inhibition augments sleep-related ultradian rhythm of parasympathetic tone in patients with chronic heart failure
    Tsugiyoshi Yamazaki
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Circ J 69:1052-6. 2005
    ..01). CONCLUSIONS: Central sympathoinhibition augments a sleep-related ultradian rhythm of parasympathetic tone, suggesting a potential benefit to autonomic balancing and sleep quality in patients with chronic heart failure...
  23. ncbi Transient hypercapnic stress causes exaggerated and prolonged elevation of cardiac and renal interstitial norepinephrine levels in conscious hypertensive rats
    Mitsuo Sobajima
    The Second Dept of Internal Medicine, Graduate School of Medicine, Univ of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Am J Physiol Heart Circ Physiol 300:H2214-20. 2011
    ..In conclusion, transient hypercapnic stress causes exaggerated and prolonged elevation of iNE levels in the heart as well as in kidneys of SS animals...
  24. ncbi Left atrial appendage function and abnormal hypercoagulability in patients with atrial flutter
    Kenji Sakurai
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    Chest 124:1670-4. 2003
    ..However, patients with AFL and impaired LAA function are at potentially high risk for thromboembolism and might require anticoagulation...
  25. ncbi Effects of anticoagulation intensity on hemostatic markers in patients with non-valvular atrial fibrillation
    Takashi Nozawa
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Circ J 68:29-34. 2004
    ..2 and D-dimer in patients with NVAF, and might be favorable in Japanese patients with NVAF in view of the balance between prevention of thromboembolism and the adverse effect by warfarin (ie, bleeding)...
  26. ncbi Present status of anticoagulation treatment in Japanese patients with atrial fibrillation: a report from the J-RHYTHM Registry
    Hirotsugu Atarashi
    Department of Internal Medicine, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan
    Circ J 75:1328-33. 2011
    ..Underuse and an inadequate range for the international normalized ratio (INR) for warfarin use are still problems in the management of the patients with atrial fibrillation (AF) in Japan...
  27. ncbi Tranilast prevents atrial remodeling and development of atrial fibrillation in a canine model of atrial tachycardia and left ventricular dysfunction
    Yosuke Nakatani
    Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    J Am Coll Cardiol 61:582-8. 2013
    ..This study sought to assess the effects of tranilast on atrial remodeling in a canine atrial fibrillation (AF) model...
  28. ncbi Nonlinear mixed effects model analysis of the pharmacokinetics of metoprolol in routinely treated Japanese patients
    Masato Taguchi
    Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Biol Pharm Bull 27:1642-8. 2004
    ....
  29. ncbi Drug-induced changes in fibrillation cycle length and organization index can predict chemical cardioversion of long-lasting atrial fibrillation with bepridil alone or in combination with aprindine
    Akira Fujiki
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    Circ J 68:1139-45. 2004
    ..The aim of this study was to investigate whether drug-induced changes in fibrillation wave characteristics can predict pharmacological conversion of long lasting persistent atrial fibrillation (AF)...
  30. ncbi Plaque regression in one artery is not necessarily associated with parallel changes in other vascular beds
    Takayuki Suzuki
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930 0194, Japan
    Heart Vessels 26:242-51. 2011
    ..Changes in soft plaques over 2 years paralleled those of VWAs in both coronary arteries. In conclusion, the progression or regression of atherosclerotic plaques is inhomogeneous among the vascular beds of patients with CAD...
  31. ncbi Early repolarization in Wolff-Parkinson-White syndrome: prevalence and clinical significance
    Koichi Mizumaki
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Europace 13:1195-200. 2011
    ..The present study was designed to evaluate the prevalence and clinical significance of ER in patients with WPW syndrome...
  32. ncbi Clinical and transesophageal echocardiographic variables for prediction of thromboembolic events in patients with nonvalvular atrial fibrillation at low-intermediate risk
    Etsuko Sasahara
    Department of Neurology, Toyama University Hospital, Toyama, Japan
    J Cardiol 60:484-8. 2012
    ..There is no clear consensus about antithrombotic treatment in atrial fibrillation (AF) patients at low-intermediate thromboembolic risk. Transesophageal echocardiography (TEE) is useful for prediction of thromboembolic events in AF...
  33. ncbi Discrepant recovery course of sympathetic neuronal function and beta-adrenoceptors in rat hearts after reperfusion following transient ischemia
    Bun ichi Kato
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Nucl Med 45:1074-80. 2004
    ..Accordingly, this study was performed to investigate serial changes in sympathetic neuronal function and beta-adrenoceptors after transient myocardial ischemia...
  34. ncbi Role of central sympathoexcitation in enhanced hypercapnic chemosensitivity in patients with heart failure
    Kunihiro Yamada
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Am Heart J 148:964-70. 2004
    ....
  35. ncbi Effects of the angiotensin-converting enzyme inhibitor enalapril on sympathetic neuronal function and beta-adrenergic desensitization in heart failure after myocardial infarction in rats
    Akihiko Igawa
    2nd Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
    Jpn Heart J 43:675-88. 2002
    ..These results suggest that the major effect of the ACE inhibitor enalapril in the treatment of heart failure is not due to sympathoinhibition or restoration of beta-adrenergic pathway in this model of heart failure...
  36. ncbi Enalapril prevents perpetuation of atrial fibrillation by suppressing atrial fibrosis and over-expression of connexin43 in a canine model of atrial pacing-induced left ventricular dysfunction
    Masao Sakabe
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Pharmacol 43:851-9. 2004
    ..3 +/- 2.2 versus 1.1 +/- 1.1%, P < 0.05). CONCLUSIONS: Enalapril suppressed atrial pacing-induced AF with tachycardia-mediated cardiomyopathy by suppressing interstitial fibrosis, connexin43 over-expression and conduction delay...
  37. ncbi Bradycardia-dependent ECG changes in Brugada syndrome
    Koichi Mizumaki
    The Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan
    Circ J 70:896-901. 2006
    ..The present study aimed to examine the difference in bradycardia-dependent changes in the ECG of symptomatic and asymptomatic BS patients...
  38. ncbi Pharmacokinetics of R- and S-carvedilol in routinely treated Japanese patients with heart failure
    Isao Horiuchi
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 31:976-80. 2008
    ..89 and 1.52 l/h/kg, respectively, considerably lower than those estimated previously in healthy subjects. These results suggested that the pharmacokinetics of R- and S-carvedilol was altered significantly by heart failure...
  39. ncbi Circadian dynamics of heart rate and physical activity in patients with heart failure
    Tsugiyoshi Yamazaki
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Clin Exp Hypertens 27:241-9. 2005
    ....
  40. ncbi Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias
    Masato Taguchi
    Graduate School of Pharmaceutical Sciences, University of Toyama, Sugitani, Japan
    Biol Pharm Bull 29:517-21. 2006
    ..On the other hand, no significant effect of the CYP3A5 polymorphism was observed on the pharmacokinetics of bepridil. In addition, aprindine seemed to reduce the oral clearance of bepridil in the patients with the CYP2D6*10 allele...
  41. ncbi Ischemic preconditioning accelerates the fatty acid oxidation of rat hearts
    Akira Matsuki
    The Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Sugitani, Toyama, Japan
    Int J Cardiol 132:405-10. 2009
    ..The purpose of the present study was to clarify the effects of IPC on myocardial accumulation of fatty acid (FA) tracer and its intracellular metabolism...
  42. ncbi Vagal activity modulates spontaneous augmentation of ST elevation in the daily life of patients with Brugada syndrome
    Koichi Mizumaki
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Electrophysiol 15:667-73. 2004
    ..The aim of the present study was to elucidate the relation between spontaneous augmentation of ST elevation and changes in autonomic nervous activities in the daily life of patients with Brugada syndrome...
  43. ncbi Attenuated respiratory modulation of chemoreflex-mediated sympathoexcitation in patients with chronic heart failure
    Hiroshi Ueno
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    J Card Fail 10:236-43. 2004
    ....
  44. ncbi Pulse-synchronous sympathetic burst power as a new index of sympathoexcitation in patients with heart failure
    Yoshitaka Oda
    Second Dept. of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
    Am J Physiol Heart Circ Physiol 287:H1821-7. 2004
    ..001). The sympathetic burst power reflects both burst frequency and amplitude independently of the absolute values and provides a sensitive new index for interindividual comparisons of sympathetic activity in patients with heart failure...
  45. ncbi Vagal activity modulates spontaneous augmentation of J-wave elevation in patients with idiopathic ventricular fibrillation
    Koichi Mizumaki
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Toyama, Japan
    Heart Rhythm 9:249-55. 2012
    ..Although J-wave elevation in the inferolateral leads could be related to idiopathic ventricular fibrillation (IVF), little is known about the pathophysiologic characteristics of J-wave elevation in patients with IVF...
  46. ncbi Effect of repeated sauna treatment on exercise tolerance and endothelial function in patients with chronic heart failure
    Takashi Ohori
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Japan
    Am J Cardiol 109:100-4. 2012
    ..In conclusion, repeated sauna therapy in patients with chronic heart failure improves exercise tolerance in association with improvement in endothelial function...
  47. ncbi Effect of genetic variation of IL-13 on airway remodeling in bronchial asthma
    Hiromi Nagashima
    Division of Pulmonary Medicine, Allergy, and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Japan
    Allergol Int 60:291-8. 2011
    ..Therefore, we investigated whether Q110/Q110 accelerated the decline in pulmonary function and development of airway remodeling of asthmatic patients in the general population...
  48. ncbi Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation
    Akira Fujiki
    Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan
    J Cardiovasc Pharmacol 50:264-6. 2007
    ....
  49. ncbi Postprandial augmentation of bradycardia-dependent ST elevation in patients with Brugada syndrome
    Koichi Mizumaki
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Toyama, Japan
    J Cardiovasc Electrophysiol 18:839-44. 2007
    ..Recently, glucose-induced insulin secretion was also reported to contribute to fluctuation of ST elevation. Therefore, we assessed the effects of taking meals on the ST-RR relationship in the daily life of patients with Brugada syndrome...
  50. ncbi Attitudes of Japanese cardiologists toward anticoagulation for nonvalvular atrial fibrillation and reasons for its underuse
    Hiroshi Inoue
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Circ J 68:417-21. 2004
    ....
  51. ncbi Entrainment mapping of dual-loop macroreentry in common atrial flutter: new insights into the atrial flutter circuit
    Akira Fujiki
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Electrophysiol 15:679-85. 2004
    ..The aim of this study was to determine using entrainment mapping whether the reentrant circuit of common type atrial flutter (AFL) is single loop or dual loop...
  52. ncbi Saturated glucose uptake capacity and impaired fatty acid oxidation in hypertensive hearts before development of heart failure
    Nozomu Fujii
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan
    Am J Physiol Heart Circ Physiol 287:H760-6. 2004
    ..These changes in both glucose and fatty acid metabolism that occur in association with myocardial hypertrophy may have a pathogenic role in the subsequent development of heart failure...
  53. ncbi Dynamic changes in the QT-R-R relationship during head-up tilt test in patients with vasovagal syncope
    Koichi Mizumaki
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    Ann Noninvasive Electrocardiol 10:16-24. 2005
    ..This study aimed to evaluate dynamic response of QT interval to transient changes in R-R interval during vasovagal syncope (VVS) induced by head-up tilt test...
  54. ncbi Prothrombotic activity is increased in patients with nonvalvular atrial fibrillation and risk factors for embolism
    Hiroshi Inoue
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
    Chest 126:687-92. 2004
    ..CONCLUSIONS: NVAF patients whose conditions were complicated with risk factors for embolism could be in the prothrombotic state. Advanced age is a strong predictor of the prothrombotic state in NVAF patients...
  55. ncbi Impact of preinterventional plaque composition and eccentricity on late-acquired incomplete stent apposition after sirolimus-eluting stent implantation: an intravascular ultrasound radiofrequency analysis
    Takao Sato
    The Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    Coron Artery Dis 23:432-7. 2012
    ....
  56. ncbi Rate control and quality of life in patients with permanent atrial fibrillation: the Quality of Life and Atrial Fibrillation (QOLAF) Study
    Takayuki Tsuneda
    The Second Department of Internal Medicine, University of Toyama, Japan
    Circ J 70:965-70. 2006
    ..CONCLUSION: These results indicate that CAA is preferable to digitalis when monotherapy is selected for short-term improvement of QOL and exercise tolerance in patients with permanent AF...
  57. ncbi Brief episode of myocardial ischemia before prolonged ischemia attenuates cardiac sympathetic nerve injury
    Teruo Nakadate
    The Second Department of Internal Medicine, University of Toyama, School of Medicine, Toyama, Japan
    Circ J 70:919-25. 2006
    ..CONCLUSION: A brief episode of ischemia attenuates the sympathetic neural injury caused by subsequent prolonged ischemia and this protective effect is associated with attenuation of NE release during the prolonged ischemia...
  58. ncbi Pharmacological cardioversion of persistent atrial fibrillation with and without a history of drug-resistant paroxysmal atrial fibrillation
    Akira Fujiki
    The Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, Japan
    Circ J 70:1138-41. 2006
    ..Whether a history of drug-resistant paroxysmal AF (PAF) would affect the outcome of pharmacological conversion of persistent AF by bepridil or in combination with aprindine was evaluated in the present study...
  59. ncbi Repolarization dynamics in patients with idiopathic ventricular fibrillation: pharmacological therapy with bepridil and disopyramide
    Masataka Sugao
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Pharmacol 45:545-9. 2005
    ..Not only J wave and ST elevation but also shorter QT intervals at slower heart rates may represent an electrophysiological substrate for development of VF episodes in these specific IVF patients...
  60. ncbi Maintenance of sinus rhythm and recovery of atrial mechanical function after cardioversion with bepridil or in combination with aprindine in long-lasting persistent atrial fibrillation
    Akira Fujiki
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Circ J 68:834-9. 2004
    ..Bepridil alone or in combination with aprindine is effective for termination of persistent AF...
  61. ncbi The Japan Thrombosis Registry for Atrial Fibrillation, Coronary or Cerebrovascular Events (J-TRACE): a nation-wide, prospective large cohort study; the study design
    Hideki Origasa
    Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194, Japan
    Circ J 72:991-7. 2008
    ....
  62. ncbi Relation of the severity of mitral regurgitation to thromboembolic risk in patients with atrial fibrillation
    Nobuyuki Fukuda
    The Second Department of Internal Medicine, University of Toyama, Japan
    Int J Cardiol 146:197-201. 2011
    ..Although mitral regurgitation (MR) could be protective against left atrial (LA) blood stasis, the relationship between the severity of MR and thromboembolic risk has not been clarified in patients with AF...
  63. ncbi Early administration of fluvastatin, but not at the onset of ischemia or reperfusion, attenuates myocardial ischemia-reperfusion injury through the nitric oxide pathway rather than its antioxidant property
    Akira Matsuki
    Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, Sugitani, Toyama, Japan
    Circ J 70:1643-9. 2006
    ..CONCLUSIONS: The present results indicate that pretreatment with FV, but not just before ischemia or reperfusion, attenuates IR injury primarily through the nitric oxide pathway, not through its antioxidant property...
  64. ncbi Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte/macrophage infiltration in the heart of DOCA/salt hypertensive rats
    Kazuhiro Ishimaru
    Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    J Cardiovasc Pharmacol 50:187-94. 2007
    ....
  65. ncbi Circadian changes in autonomic function in conscious rats with heart failure: effects of amiodarone on sympathetic surge
    Takashi Ohori
    The Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Auton Neurosci 159:20-5. 2011
    ..Our experimental system could detect sympathetic surge in conscious rats. Amiodarone suppressed the sympathetic surge, which could explain, at least in part, beneficial effects of amiodarone in patients with CHF...
  66. ncbi Junctional rhythm associated with ventriculoatrial block during slow pathway ablation in atypical atrioventricular nodal re-entrant tachycardia
    Akira Fujiki
    The Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Europace 10:982-7. 2008
    ..We assessed responses to slow pathway ablation with respect to the appearance of ventriculoatrial (VA) block during junctional rhythm in both typical and atypical types of atrioventricular nodal re-entrant tachycardia (AVNRT)...
  67. ncbi Relation of left atrial blood stasis to clinical risk factors in atrial fibrillation
    Kazumasa Ohara
    The Second Department of Internal Medicine University of Toyama, Toyama, Sugitani, Toyama, Japan
    Int J Cardiol 132:210-5. 2009
    ....
  68. ncbi Significant impairment of left atrial function in patients with cardioembolic stroke caused by paroxysmal atrial fibrillation
    Yoshiharu Taguchi
    Department of Neurology at Toyama University Hospital, Toyama, Japan
    Intern Med 49:1727-32. 2010
    ..The present study examined the differences in echocardiographic findings between patients with CE caused by Paf (the Paf-CE group) and those with non-cardiogenic embolic ischemic stroke (the Non-CE group)...
  69. ncbi Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action
    Mototsugu Takashima
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes 59:1608-15. 2010
    ....
  70. ncbi Narrow QRS ventricular tachycardia from the posterior mitral annulus without involvement of the His-Purkinje system in a patient with prior inferior myocardial infarction
    Tamotsu Sakamoto
    Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930 0194, Japan
    Heart Vessels 25:170-3. 2010
    ..Synchronized excitation of both ventricles from the posterior infarcted mitral annulus in this patient may make the QRS width during VT narrow, without involvement of the His-Purkinje system...
  71. ncbi Bepridil reverses atrial electrical remodeling and L-type calcium channel downregulation in a canine model of persistent atrial tachycardia
    Kunihiro Nishida
    Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan
    J Cardiovasc Electrophysiol 18:765-72. 2007
    ..This study tested whether bepridil, a multichannel blocker, would reverse electrical remodeling induced by persistent atrial tachycardia...
  72. ncbi Investigation of optimal anticoagulation strategy for stroke prevention in Japanese patients with atrial fibrillation--the J-RHYTHM Registry study design
    Hirotsugu Atarashi
    Department of Internal Medicine, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan
    J Cardiol 57:95-9. 2011
    ..In order to prevent stroke in atrial fibrillation (AF) lower international normalized ratios (INR) (1.6-2.6) were recommended for elderly Japanese patients, but only one clinical study supported this recommendation...
  73. ncbi Repolarization abnormality in idiopathic ventricular fibrillation: assessment using 24-hour QT-RR and QaT-RR relationships
    Akira Fujiki
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    J Cardiovasc Electrophysiol 15:59-63. 2004
    ..We hypothesized that IVF patients have unique repolarization dynamics related to a reduced fast Na current and a prominent transient outward current...
  74. ncbi Parametric system identification of arterial baroreflex with random perturbation of blood pressure in normal subjects
    Kunihiro Yamada
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Pharmacol 42:S11-3. 2003
    ..This method would potentially be of great use in helping us gain insights into a closed-loop system of complex and dynamic cardiovascular regulation in humans...
  75. ncbi Atorvastatin-induced changes in plasma coenzyme q10 and brain natriuretic peptide in patients with coronary artery disease
    Takayuki Suzuki
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Toyama, Japan
    Int Heart J 49:423-33. 2008
    ..However, ATO-induced decreases in CoQ10 might not increase oxidative stress...
  76. ncbi Usefulness and safety of bepridil in converting persistent atrial fibrillation to sinus rhythm
    Akira Fujiki
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Am J Cardiol 92:472-5. 2003
    ..Bepridil is effective and safe for terminating long-lasting persistent AF...
  77. ncbi Double potentials at successful catheter ablation site of left-sided retrograde accessory pathway: mitral isthmus block or conduction through coronary sinus musculature
    Akira Fujiki
    The Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Int J Cardiol 117:90-6. 2007
    ..We studied three patients who had orthodromic atrioventricular reentrant tachycardia (AVRT) using left lateral accessory pathway (AP), with difficulty in identifying the earliest site of retrograde atrial activation...
  78. ncbi Deficiency of testosterone associates with the substrate of atrial fibrillation in the rat model
    Takayuki Tsuneda
    The Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    J Cardiovasc Electrophysiol 20:1055-60. 2009
    ..Since the prevalence of atrial fibrillation (AF) increases progressively with aging, especially in men, we hypothesized that testosterone might affect the occurrence of AF...
  79. ncbi Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus
    Taizo Nakagawa
    Second Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Sciences for Research, University ofToyama, and Fujikoshi Hospital, 2630, Sugitani, Toyama 930 0194, Japan
    Nephrol Dial Transplant 26:458-68. 2011
    ..In contrast to the well-established role of PDGFR-β in the development of kidney glomerulus, its role in adult kidney glomerulus remains controversial...
  80. ncbi Impact of sleeping position on central sleep apnea/Cheyne-Stokes respiration in patients with heart failure
    Shuji Joho
    Second Department of Internal Medicine, Toyama University Hospital, Toyama, Japan
    Sleep Med 11:143-8. 2010
    ..The present study determines the influence of sleeping position on central sleep apnea (CSA) in patients with heart failure (HF)...
  81. ncbi The effects of light on sex determination in gametophytes of the fern Ceratopteris richardii
    Hiroyuki Kamachi
    Graduate School of Science and Engineering, University of Toyama, 3190 Gofuku, Toyama 930 8555, Japan
    J Plant Res 120:629-34. 2007
    ..The results of experiments with a photomorphogenic mutant also suggested that phytochrome may be involved in the action of red light...
  82. ncbi Pharmacological cardioversion of long-lasting atrial fibrillation
    Akira Fujiki
    The Second Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama, Japan
    Circ J 71:A69-74. 2007
    ..Although the precise mechanism of cardioversion by bepridil is not clear, reversal of the remodeled atria may play an important role...
  83. ncbi Relation between transverse conduction capability and the anatomy of the crista terminalis in patients with atrial flutter and atrial fibrillation: analysis by intracardiac echocardiography
    Koichi Mizumaki
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Circ J 66:1113-8. 2002
    ..05). Therefore, the transverse conduction block of CT was more likely to occur in a thick CT. A limited transverse conduction capability of the CT is related to its thickness and might contribute to the development of typical AFL...
  84. ncbi [Brugada syndrome occurring in an identical twin: a case report]
    Masao Sakabe
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Faculty of Medicine, Sugitani 2630, Toyama, Toyama 930-0194
    J Cardiol 40:111-5. 2002
    ..Although SCN5A mutation is considered to be associated with Brugada syndrome, the present results suggest that the genetic factor is not the only factor responsible for the pathogenesis of Brugada syndrome...
  85. ncbi Angiotensin-converting enzyme-gene polymorphism is associated with collagen I synthesis and QT dispersion in essential hypertension
    Toru Takahashi
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Hypertens 21:985-91. 2003
    ..This study tested the hypothesis that abnormal QT dispersion, an indicator of arrhythmogenic risk, is associated with angiotensin-converting enzyme (ACE) gene polymorphism and abnormalities of collagen metabolism...
  86. ncbi Proportion and prognosis of healthy people with coved or saddle-back type ST segment elevation in the right precordial leads during 10 years follow-up
    Masao Sakabe
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Eur Heart J 24:1488-93. 2003
    ..22% and the risk of fatal arrhythmias was low (1/393.5 subject-years)...
  87. ncbi Principles of medical management of atrial fibrillation: rhythm control versus rate control
    Hiroshi Inoue
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama
    Intern Med 43:162-3. 2004
  88. ncbi [Dual atrioventricular nodal pathways]
    Tamotsu Sakamoto
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama
    Nippon Rinsho . 2007
  89. ncbi Role of fibrillation cycle length in spontaneous and drug-induced termination of human atrial fibrillation
    Akira Fujiki
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Circ J 67:391-5. 2003
    ..Spontaneous termination in the morning may be caused by an abrupt increase in FCL related to vagolytic autonomic balance...
  90. ncbi Disparate force-frequency effects of pimobendan and dobutamine in conscious dogs with tachycardia-induced cardiomyopathy
    Shuji Joho
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Card Fail 8:423-30. 2002
    ..CONCLUSIONS: Mild amplification of FFR observed in pimobendan suggests that this agent could be used more safely than beta-adrenergic agent when heart rate is increased, as seen with exercise...
  91. ncbi Cardiac sympathetic denervation modulates the sympathoexcitatory response to acute myocardial ischemia
    Shuji Joho
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Am Coll Cardiol 39:436-42. 2002
    ..344%, p < 0.05). CONCLUSIONS: These findings suggest that if the provoked ischemia is not severe, cardiac sympathetic denervation could prevent ischemia-induced sympathoexcitation...
  92. ncbi Dose-response effect of flecainide in patients with symptomatic paroxysmal atrial fibrillation and/or flutter monitored with trans-telephonic electrocardiography: a multicenter, placebo-controlled, double-blind trial
    Hirotsugu Atarashi
    Department of Internal Medicine, Nippon Medical School, Tama Nagayama Hospital, Japan
    Circ J 71:294-300. 2007
    ....
  93. ncbi Novel LAMP-2 mutation in a family with Danon disease presenting with hypertrophic cardiomyopathy
    Nobuhiro Dougu
    Department of Neurology, Toyama University Hospital, Toyama University Hospital, Toyama, Japan
    Circ J 73:376-80. 2009
    ..573delA) in exon 5. The 2 affected sisters were also heterozygous for the same mutation. Functional analyses of this novel LAMP2 mutation are mandatory...
  94. ncbi [Electrocardiographic findings]
    Hidehiko Nagasawa
    Second Department of Internal Medicine, Faculty of Medicine, University of Toyama
    Nippon Rinsho 64:176-80. 2006
  95. ncbi Effects of long-term renal sympathetic denervation on heart failure after myocardial infarction in rats
    Takashi Nozawa
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan
    Heart Vessels 16:51-6. 2002
    ..Increased renal sympathetic nerve activity might contribute to the progression of heart failure after MI...
  96. ncbi Propofol induced marked prolongation of QT interval in a patient with acute myocardial infarction
    Masao Sakabe
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    Anesthesiology 97:265-6. 2002
  97. ncbi Investigation of the optimal treatment strategy for atrial fibrillation in Japan
    Takeshi Yamashita
    J-RHYTHM Clinical Trial Center, The Cardiovascular Institute, Tokyo, Japan
    Circ J 67:738-41. 2003
    ....
  98. ncbi Identification of a novel splice site mutation of the CSPG2 gene in a Japanese family with Wagner syndrome
    Tatsuro Miyamoto
    Division of Genetic Information, Institute for Genome Research, The University of Tokushima, Tokushima, Japan
    Invest Ophthalmol Vis Sci 46:2726-35. 2005
    ..To investigate the genetic basis and clinical variability of Wagner syndrome, a rare, dominantly inherited vitreoretinopathy...
  99. ncbi Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation
    Hirotsugu Atarashi
    First Department of Internal Medicine, Nippon Medical School, Tama City, Tokyo, Japan
    Circ J 66:553-6. 2002
    ..In conclusion, neither aprindine nor digoxin had a significant effect on preventing relapse of symptomatic AF; however, recurrence of AF occurred later with aprindine than with placebo or digoxin...
  100. ncbi Complex atrial reentrant circuits evaluated by entrainment mapping using a multielectrode basket catheter
    Kunihiro Nishida
    The Second Department of Internal Medicine and Toyama Medical and Pharmaceutical University, Japan
    Circ J 68:168-71. 2004
    ..Entrainment mapping using a multielectrode basket catheter is very useful for identifying complex atrial reentrant circuits...
  101. ncbi Novel mutant phenotypes of a dark-germinating mutant dkg1 in the fern Ceratopteris richardii
    Hiroyuki Kamachi
    Department of Environmental Biology and Chemistry, Faculty of Science, Toyama University, Gofuku, Toyama 930 8555, Japan
    J Plant Res 117:163-70. 2004
    ..These results indicate that the DKG1 gene is pleiotropic and is involved in several phytochrome-mediated responses in the gametophyte development of C. richardii...