Hiroshi Inoue

Summary

Affiliation: University of Toyama
Country: Japan

Publications

  1. ncbi request reprint Canine model of Brugada syndrome using regional epicardial cooling of the right ventricular outflow tract
    Kunihiro Nishida
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Electrophysiol 15:936-41. 2004
  2. ncbi request reprint Enalapril preserves sinus node function in a canine atrial fibrillation model induced by rapid atrial pacing
    Masao Sakabe
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Electrophysiol 16:1209-14. 2005
  3. doi request reprint Impact of gender on the prognosis of patients with nonvalvular atrial fibrillation
    Hiroshi Inoue
    Second Department of Internal Medicine, Toyama University Hospital, Toyama, Japan Electronic address
    Am J Cardiol 113:957-62. 2014
  4. doi request reprint Thromboembolism in patients with nonvalvular atrial fibrillation: comparison between Asian and Western countries
    Hiroshi Inoue
    Second Department of Internal Medicine, Toyama University Hospital, 2630 Sugitani, Toyama City, Toyama 930 0194, Japan
    J Cardiol 61:1-7. 2013
  5. ncbi request reprint Sex-related differences in the risk factor profile and medications of patients with atrial fibrillation recruited in J-TRACE
    Hiroshi Inoue
    Department of Internal Medicine, University of Toyama, Toyama, Japan
    Circ J 74:650-4. 2010
  6. doi request reprint Prevalence of atrial fibrillation in the general population of Japan: an analysis based on periodic health examination
    Hiroshi Inoue
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Sugitani, Toyama, Japan
    Int J Cardiol 137:102-7. 2009
  7. ncbi request reprint Accumulation of risk factors increases risk of thromboembolic events in patients with nonvalvular atrial fibrillation
    Hiroshi Inoue
    Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    Circ J 70:651-6. 2006
  8. ncbi request reprint d,l-Sotalol reverses abbreviated atrial refractoriness and prevents promotion of atrial fibrillation in a canine model with left ventricular dysfunction induced by atrial tachypacing
    Tamotsu Sakamoto
    Second Department of Internal Medicine, University of Toyama, Japan
    Circ J 73:1820-8. 2009
  9. ncbi request reprint Accumulation of risk factors enhances the prothrombotic state in atrial fibrillation
    Kazumasa Ohara
    Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Int J Cardiol 126:316-21. 2008
  10. ncbi request reprint Thoracic aortic plaque enhances hypercoagulability in patients with nonrheumatic atrial fibrillation
    Keiko Nakagawa
    Second Department of Internal Medicine, University of Toyama, Japan
    Circ J 71:52-6. 2007

Detail Information

Publications125 found, 100 shown here

  1. ncbi request reprint Canine model of Brugada syndrome using regional epicardial cooling of the right ventricular outflow tract
    Kunihiro Nishida
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Electrophysiol 15:936-41. 2004
    ..We determined the effect of regional epicardial cooling of the right ventricular outflow tract (RVOT) on surface ECG and ventricular vulnerability in the dog...
  2. ncbi request reprint Enalapril preserves sinus node function in a canine atrial fibrillation model induced by rapid atrial pacing
    Masao Sakabe
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Electrophysiol 16:1209-14. 2005
    ..9%, P < 0.05; AT, 4.0 +/- 1.7%, P < 0.05) and in group II dogs (IF, 4.0 +/- 2.0%, P < 0.05; AT, 4.0 +/- 1.7%, P < 0.05). End-labeling assay was positive in three of nine dogs in group I, but negative in group II and sham dogs...
  3. doi request reprint Impact of gender on the prognosis of patients with nonvalvular atrial fibrillation
    Hiroshi Inoue
    Second Department of Internal Medicine, Toyama University Hospital, Toyama, Japan Electronic address
    Am J Cardiol 113:957-62. 2014
    ..In conclusion, female gender is not a risk factor for thromboembolic events among Japanese patients with NVAF who were treated mostly with warfarin. However, male gender is a risk factor for major hemorrhaging and all-cause mortality...
  4. doi request reprint Thromboembolism in patients with nonvalvular atrial fibrillation: comparison between Asian and Western countries
    Hiroshi Inoue
    Second Department of Internal Medicine, Toyama University Hospital, 2630 Sugitani, Toyama City, Toyama 930 0194, Japan
    J Cardiol 61:1-7. 2013
    ..New oral anticoagulants have been launched in Japan as an alternative to warfarin. The management strategy for AF patients needs to be modified based on the data obtained from Japanese patients...
  5. ncbi request reprint Sex-related differences in the risk factor profile and medications of patients with atrial fibrillation recruited in J-TRACE
    Hiroshi Inoue
    Department of Internal Medicine, University of Toyama, Toyama, Japan
    Circ J 74:650-4. 2010
    ..Whether such a difference exists for Japanese patients with AF is unclear, so data from J-TRACE were used to investigate this issue...
  6. doi request reprint Prevalence of atrial fibrillation in the general population of Japan: an analysis based on periodic health examination
    Hiroshi Inoue
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Sugitani, Toyama, Japan
    Int J Cardiol 137:102-7. 2009
    ..The age- and gender-specific prevalence rate of atrial fibrillation (AF) in the general population of Japan was determined using the data from periodic health examinations in 2003...
  7. ncbi request reprint Accumulation of risk factors increases risk of thromboembolic events in patients with nonvalvular atrial fibrillation
    Hiroshi Inoue
    Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    Circ J 70:651-6. 2006
    ..To validate this hypothesis, a post hoc analysis was performed to determine the relationship of risk levels and thromboembolic events in patients with NVAF from our previous prospective study...
  8. ncbi request reprint d,l-Sotalol reverses abbreviated atrial refractoriness and prevents promotion of atrial fibrillation in a canine model with left ventricular dysfunction induced by atrial tachypacing
    Tamotsu Sakamoto
    Second Department of Internal Medicine, University of Toyama, Japan
    Circ J 73:1820-8. 2009
    ..This study evaluated antiarrhythmic effects of d,l-sotalol in a canine atrial fibrillation (AF) model with left ventricular dysfunction...
  9. ncbi request reprint Accumulation of risk factors enhances the prothrombotic state in atrial fibrillation
    Kazumasa Ohara
    Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Int J Cardiol 126:316-21. 2008
    ..The present study was conducted to investigate the relation between the accumulation of the risk factors of thromboembolism and the levels of hemostatic markers in patients with nonvalvular atrial fibrillation (NVAF)...
  10. ncbi request reprint Thoracic aortic plaque enhances hypercoagulability in patients with nonrheumatic atrial fibrillation
    Keiko Nakagawa
    Second Department of Internal Medicine, University of Toyama, Japan
    Circ J 71:52-6. 2007
    ..The relationship between plasma hemostatic markers and aortic atherosclerosis was determined in patients with AF or in sinus rhythm (SR)...
  11. ncbi request reprint Influence of CYP2D6 genotype on metoprolol plasma concentration and beta-adrenergic inhibition during long-term treatment: a comparison with bisoprolol
    Takashi Nozawa
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Cardiovasc Pharmacol 46:713-20. 2005
    ..In contrast, bisoprolol has a relatively constant beta-adrenergic inhibition independent of CYP2D6 genotype...
  12. ncbi request reprint D-dimer level influences thromboembolic events in patients with atrial fibrillation
    Takashi Nozawa
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930 0194, Nagasaki, Japan
    Int J Cardiol 109:59-65. 2006
    ..A prospective, cooperative study was conducted to determine whether levels of coagulative markers alone or in combination with clinical risk factors could predict subsequent thromboembolic events in patients with NVAF...
  13. ncbi request reprint UGT2B7*3 did not affect the pharmacokinetics of R- and S-carvedilol in healthy Japanese
    Mutsuko Honda
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Drug Metab Pharmacokinet 22:382-6. 2007
    ....
  14. doi request reprint Chronic kidney disease and CHADS(2) score independently predict cardiovascular events and mortality in patients with nonvalvular atrial fibrillation
    Keiko Nakagawa
    Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    Am J Cardiol 107:912-6. 2011
    ..Long-term mortality, cardiac events, and stroke risk were >8 times higher when decreased eGFR (<60 ml/min/1.73 m(2)) was present with higher CHADS(2) score (≥2)...
  15. ncbi request reprint Multiple regression analysis of pharmacogenetic variability of carvedilol disposition in 54 healthy Japanese volunteers
    Mutsuko Honda
    Graduate School of Pharmaceutical Sciences, University of Toyama, Sugitani, Japan
    Biol Pharm Bull 29:772-8. 2006
    ..On the other hand, CYP2C9*3, CYP2C19*2, CYP2C19*3, CYP3A5*3, UGT2B7*2, and MDR1 C3435T did not significantly affect the pharmacokinetics of carvedilol in Japanese subjects...
  16. ncbi request reprint Supersensitive response to isoproterenol in patients with marked global reduction of cardiac metaiodobenzylguanidine uptake
    Naohiro Yoshida
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Circ J 67:745-9. 2003
    ..4%) and II (2.6+/-1.7 mm and 8.9+/-7.9%). The present results suggest that the sympathetically denervated human heart is supersensitive to IP and the exaggerated responses may be caused, at least in part, by a postsynaptic mechanism...
  17. ncbi request reprint Anticoagulation control quality affects the D-dimer levels of atrial fibrillation patients
    Yosuke Nakatani
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Japan
    Circ J 76:317-21. 2012
    ..Anticoagulation control quality affects the incidence of thromboembolic events in atrial fibrillation (AF) patients. However, the effects of anticoagulation control quality on the prothrombotic state of AF patients are unclear...
  18. ncbi request reprint Fluvastatin attenuates diabetes-induced cardiac sympathetic neuropathy in association with a decrease in oxidative stress
    Akira Matsuki
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Circ J 74:468-75. 2010
    ..Increased oxidative stress might contribute to diabetic (DM) neuropathy, so the effects of long-term treatment with fluvastatin (FL) on myocardial oxidative stress and cardiac sympathetic neural function were investigated in diabetic rats...
  19. ncbi request reprint Influence of beta-adrenoceptor blockade on the myocardial accumulation of fatty acid tracer and its intracellular metabolism in the heart after ischemia-reperfusion injury
    Norio Igarashi
    Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama 930 0194, Japan
    Circ J 70:1509-14. 2006
    ..Therefore, the beneficial effects of beta-adrenoceptor blockade on myocardial ischemic injury might result from the suppression of FA accumulation...
  20. ncbi request reprint Prolonged activation of hemostatic markers following conversion of atrial flutter to sinus rhythm
    Kenji Sakurai
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugutani, Toyama 930 0194, Japan
    Circ J 68:1041-4. 2004
    ..To evaluate the potential prothrombotic state following cardioversion of AFL, concentrations of hemostatic markers were determined before and after conversion to sinus rhythm (SR)...
  21. ncbi request reprint Evaluation of fatty acid metabolism in hearts after ischemia-reperfusion injury using a dual-isotope autoradiographic approach and tissue assay for metabolites of tracer
    Norio Igarashi
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Nucl Med 46:160-4. 2005
    ..We investigated whether changes in myocardial uptake of fatty acid tracer after reperfusion following transient myocardial ischemia were closely related to alterations in intracellular fatty acid oxidation...
  22. ncbi request reprint Target international normalized ratio values for preventing thromboembolic and hemorrhagic events in Japanese patients with non-valvular atrial fibrillation: results of the J-RHYTHM Registry
    Hiroshi Inoue
    Second Department of Internal Medicine, Toyama University Hospital
    Circ J 77:2264-70. 2013
    ..Target anticoagulation levels for warfarin in Japanese patients with non-valvular atrial fibrillation (NVAF) are unclear...
  23. ncbi request reprint Present status of anticoagulation treatment in Japanese patients with atrial fibrillation: a report from the J-RHYTHM Registry
    Hirotsugu Atarashi
    Department of Internal Medicine, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan
    Circ J 75:1328-33. 2011
    ..Underuse and an inadequate range for the international normalized ratio (INR) for warfarin use are still problems in the management of the patients with atrial fibrillation (AF) in Japan...
  24. doi request reprint Repeated sauna therapy attenuates ventricular remodeling after myocardial infarction in rats by increasing coronary vascularity of noninfarcted myocardium
    Mitsuo Sobajima
    The Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Sugitani, Toyama, Japan
    Am J Physiol Heart Circ Physiol 301:H548-54. 2011
    ..In conclusion, ST attenuates cardiac remodeling after MI, at least in part, through improving coronary vascularity in the noninfarcted myocardium. Repeated ST might serve as a novel noninvasive therapy for patients with MI...
  25. doi request reprint Combination therapy of candesartan with statin inhibits progression of atherosclerosis more than statin alone in patients with coronary artery disease
    Takayuki Suzuki
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Toyama, Japan
    Coron Artery Dis 22:352-8. 2011
    ..However, it remains unclear whether combination therapy of RAS inhibitor with statin could inhibit plaque progression more than statin alone...
  26. ncbi request reprint Central sympathetic inhibition augments sleep-related ultradian rhythm of parasympathetic tone in patients with chronic heart failure
    Tsugiyoshi Yamazaki
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Circ J 69:1052-6. 2005
    ..This study was designed to examine whether central sympathoinhibition could improve the sympathovagal imbalance related to rapid-eye-movement (REM)/non-REM ultradian sleep rhythm in these patients...
  27. doi request reprint Transient hypercapnic stress causes exaggerated and prolonged elevation of cardiac and renal interstitial norepinephrine levels in conscious hypertensive rats
    Mitsuo Sobajima
    The Second Dept of Internal Medicine, Graduate School of Medicine, Univ of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Am J Physiol Heart Circ Physiol 300:H2214-20. 2011
    ..In conclusion, transient hypercapnic stress causes exaggerated and prolonged elevation of iNE levels in the heart as well as in kidneys of SS animals...
  28. ncbi request reprint Effects of anticoagulation intensity on hemostatic markers in patients with non-valvular atrial fibrillation
    Takashi Nozawa
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Circ J 68:29-34. 2004
    ..The aim of this study was to determine the effects of anticoagulation intensity on hemostatic markers in patients with NVAF...
  29. ncbi request reprint Left atrial appendage function and abnormal hypercoagulability in patients with atrial flutter
    Kenji Sakurai
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    Chest 124:1670-4. 2003
    ..To evaluate the potential prothrombotic state in patients with AFL, TEE findings and hemostatic markers were compared among patient groups with AFL, normal sinus rhythm (NSR) and chronic nonvalvular atrial fibrillation (AF)...
  30. doi request reprint Repeated sauna therapy improves myocardial perfusion in patients with chronically occluded coronary artery-related ischemia
    Mitsuo Sobajima
    The Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Int J Cardiol 167:237-43. 2013
    ..We investigated whether Waon therapy could improve myocardial perfusion in patients with ischemia related to chronic total occlusion (CTO) of coronary arteries...
  31. ncbi request reprint Discrepant recovery course of sympathetic neuronal function and beta-adrenoceptors in rat hearts after reperfusion following transient ischemia
    Bun ichi Kato
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Nucl Med 45:1074-80. 2004
    ..Accordingly, this study was performed to investigate serial changes in sympathetic neuronal function and beta-adrenoceptors after transient myocardial ischemia...
  32. doi request reprint Imbalance of renal production between 5-hydroxytryptamine and dopamine in patients with essential hypertension complicated by microalbuminuria
    Masayo Hirose
    Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    Am J Hypertens 26:227-33. 2013
    ..The present study was designed to explore whether rates of renal production of 5-HT relative to that of DA are altered in patients with essential hypertension and microalbuminuria...
  33. doi request reprint Increased blood viscosity is associated with reduced renal function and elevated urinary albumin excretion in essential hypertensives without chronic kidney disease
    Hiroko Sugimori
    The Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    Hypertens Res 36:247-51. 2013
    ..058) and urinary albumin excretion (R(2)=0.216). In conclusion, increased blood viscosity may be a risk for development of renal disease in EHT...
  34. doi request reprint Tranilast prevents atrial remodeling and development of atrial fibrillation in a canine model of atrial tachycardia and left ventricular dysfunction
    Yosuke Nakatani
    Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    J Am Coll Cardiol 61:582-8. 2013
    ..This study sought to assess the effects of tranilast on atrial remodeling in a canine atrial fibrillation (AF) model...
  35. ncbi request reprint Nonlinear mixed effects model analysis of the pharmacokinetics of metoprolol in routinely treated Japanese patients
    Masato Taguchi
    Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Biol Pharm Bull 27:1642-8. 2004
    ....
  36. doi request reprint Early repolarization in Wolff-Parkinson-White syndrome: prevalence and clinical significance
    Koichi Mizumaki
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Europace 13:1195-200. 2011
    ..The present study was designed to evaluate the prevalence and clinical significance of ER in patients with WPW syndrome...
  37. doi request reprint Plaque regression in one artery is not necessarily associated with parallel changes in other vascular beds
    Takayuki Suzuki
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930 0194, Japan
    Heart Vessels 26:242-51. 2011
    ..Changes in soft plaques over 2 years paralleled those of VWAs in both coronary arteries. In conclusion, the progression or regression of atherosclerotic plaques is inhomogeneous among the vascular beds of patients with CAD...
  38. ncbi request reprint Drug-induced changes in fibrillation cycle length and organization index can predict chemical cardioversion of long-lasting atrial fibrillation with bepridil alone or in combination with aprindine
    Akira Fujiki
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    Circ J 68:1139-45. 2004
    ..The aim of this study was to investigate whether drug-induced changes in fibrillation wave characteristics can predict pharmacological conversion of long lasting persistent atrial fibrillation (AF)...
  39. doi request reprint Clinical and transesophageal echocardiographic variables for prediction of thromboembolic events in patients with nonvalvular atrial fibrillation at low-intermediate risk
    Etsuko Sasahara
    Department of Neurology, Toyama University Hospital, Toyama, Japan
    J Cardiol 60:484-8. 2012
    ..There is no clear consensus about antithrombotic treatment in atrial fibrillation (AF) patients at low-intermediate thromboembolic risk. Transesophageal echocardiography (TEE) is useful for prediction of thromboembolic events in AF...
  40. ncbi request reprint Role of central sympathoexcitation in enhanced hypercapnic chemosensitivity in patients with heart failure
    Kunihiro Yamada
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Am Heart J 148:964-70. 2004
    ..The present study was designed to elucidate the role of central sympathetic activity in the enhancement of hypercapnic chemosensitivity...
  41. ncbi request reprint Enalapril prevents perpetuation of atrial fibrillation by suppressing atrial fibrosis and over-expression of connexin43 in a canine model of atrial pacing-induced left ventricular dysfunction
    Masao Sakabe
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Pharmacol 43:851-9. 2004
    ..Effects of enalapril on a canine model of atrial pacing-induced atrial fibrillation (AF) with rapid ventricular responses were determined...
  42. ncbi request reprint Effects of the angiotensin-converting enzyme inhibitor enalapril on sympathetic neuronal function and beta-adrenergic desensitization in heart failure after myocardial infarction in rats
    Akihiko Igawa
    2nd Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Jpn Heart J 43:675-88. 2002
    ..These results suggest that the major effect of the ACE inhibitor enalapril in the treatment of heart failure is not due to sympathoinhibition or restoration of beta-adrenergic pathway in this model of heart failure...
  43. ncbi request reprint Vagal activity modulates spontaneous augmentation of ST elevation in the daily life of patients with Brugada syndrome
    Koichi Mizumaki
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Electrophysiol 15:667-73. 2004
    ..The aim of the present study was to elucidate the relation between spontaneous augmentation of ST elevation and changes in autonomic nervous activities in the daily life of patients with Brugada syndrome...
  44. ncbi request reprint Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias
    Masato Taguchi
    Graduate School of Pharmaceutical Sciences, University of Toyama, Sugitani, Japan
    Biol Pharm Bull 29:517-21. 2006
    ..On the other hand, no significant effect of the CYP3A5 polymorphism was observed on the pharmacokinetics of bepridil. In addition, aprindine seemed to reduce the oral clearance of bepridil in the patients with the CYP2D6*10 allele...
  45. ncbi request reprint Circadian dynamics of heart rate and physical activity in patients with heart failure
    Tsugiyoshi Yamazaki
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Clin Exp Hypertens 27:241-9. 2005
    ....
  46. ncbi request reprint Bradycardia-dependent ECG changes in Brugada syndrome
    Koichi Mizumaki
    The Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan
    Circ J 70:896-901. 2006
    ..The present study aimed to examine the difference in bradycardia-dependent changes in the ECG of symptomatic and asymptomatic BS patients...
  47. doi request reprint Ischemic preconditioning accelerates the fatty acid oxidation of rat hearts
    Akira Matsuki
    The Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Sugitani, Toyama, Japan
    Int J Cardiol 132:405-10. 2009
    ..The purpose of the present study was to clarify the effects of IPC on myocardial accumulation of fatty acid (FA) tracer and its intracellular metabolism...
  48. ncbi request reprint Pharmacokinetics of R- and S-carvedilol in routinely treated Japanese patients with heart failure
    Isao Horiuchi
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 31:976-80. 2008
    ..89 and 1.52 l/h/kg, respectively, considerably lower than those estimated previously in healthy subjects. These results suggested that the pharmacokinetics of R- and S-carvedilol was altered significantly by heart failure...
  49. ncbi request reprint Pulse-synchronous sympathetic burst power as a new index of sympathoexcitation in patients with heart failure
    Yoshitaka Oda
    Second Dept of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Am J Physiol Heart Circ Physiol 287:H1821-7. 2004
    ..001). The sympathetic burst power reflects both burst frequency and amplitude independently of the absolute values and provides a sensitive new index for interindividual comparisons of sympathetic activity in patients with heart failure...
  50. ncbi request reprint Attenuated respiratory modulation of chemoreflex-mediated sympathoexcitation in patients with chronic heart failure
    Hiroshi Ueno
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    J Card Fail 10:236-43. 2004
    ..This study was designed to evaluate the dynamic aspects of sympathoexcitation caused by central hypercapnic chemoreflex in patients with chronic heart failure...
  51. doi request reprint Effect of genetic variation of IL-13 on airway remodeling in bronchial asthma
    Hiromi Nagashima
    Division of Pulmonary Medicine, Allergy, and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Japan
    Allergol Int 60:291-8. 2011
    ..Therefore, we investigated whether Q110/Q110 accelerated the decline in pulmonary function and development of airway remodeling of asthmatic patients in the general population...
  52. doi request reprint Effect of repeated sauna treatment on exercise tolerance and endothelial function in patients with chronic heart failure
    Takashi Ohori
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Japan
    Am J Cardiol 109:100-4. 2012
    ..In conclusion, repeated sauna therapy in patients with chronic heart failure improves exercise tolerance in association with improvement in endothelial function...
  53. ncbi request reprint Relation of interleukin-6 and C-reactive protein levels to sinus maintenance after pharmacological cardioversion in persistent atrial fibrillation
    Akira Fujiki
    Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan
    J Cardiovasc Pharmacol 50:264-6. 2007
    ....
  54. ncbi request reprint Postprandial augmentation of bradycardia-dependent ST elevation in patients with Brugada syndrome
    Koichi Mizumaki
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Toyama, Japan
    J Cardiovasc Electrophysiol 18:839-44. 2007
    ..Recently, glucose-induced insulin secretion was also reported to contribute to fluctuation of ST elevation. Therefore, we assessed the effects of taking meals on the ST-RR relationship in the daily life of patients with Brugada syndrome...
  55. ncbi request reprint Entrainment mapping of dual-loop macroreentry in common atrial flutter: new insights into the atrial flutter circuit
    Akira Fujiki
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Electrophysiol 15:679-85. 2004
    ..The aim of this study was to determine using entrainment mapping whether the reentrant circuit of common type atrial flutter (AFL) is single loop or dual loop...
  56. ncbi request reprint Attitudes of Japanese cardiologists toward anticoagulation for nonvalvular atrial fibrillation and reasons for its underuse
    Hiroshi Inoue
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Circ J 68:417-21. 2004
    ....
  57. doi request reprint Vagal activity modulates spontaneous augmentation of J-wave elevation in patients with idiopathic ventricular fibrillation
    Koichi Mizumaki
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Toyama, Japan
    Heart Rhythm 9:249-55. 2012
    ..Although J-wave elevation in the inferolateral leads could be related to idiopathic ventricular fibrillation (IVF), little is known about the pathophysiologic characteristics of J-wave elevation in patients with IVF...
  58. ncbi request reprint Prothrombotic activity is increased in patients with nonvalvular atrial fibrillation and risk factors for embolism
    Hiroshi Inoue
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Chest 126:687-92. 2004
    ..The aim of this study was to investigate whether risk factors for embolism would promote thrombus formation in patients with nonvalvular atrial fibrillation (NVAF)...
  59. ncbi request reprint Impact of preinterventional plaque composition and eccentricity on late-acquired incomplete stent apposition after sirolimus-eluting stent implantation: an intravascular ultrasound radiofrequency analysis
    Takao Sato
    The Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    Coron Artery Dis 23:432-7. 2012
    ....
  60. ncbi request reprint Saturated glucose uptake capacity and impaired fatty acid oxidation in hypertensive hearts before development of heart failure
    Nozomu Fujii
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Am J Physiol Heart Circ Physiol 287:H760-6. 2004
    ..These changes in both glucose and fatty acid metabolism that occur in association with myocardial hypertrophy may have a pathogenic role in the subsequent development of heart failure...
  61. ncbi request reprint Dynamic changes in the QT-R-R relationship during head-up tilt test in patients with vasovagal syncope
    Koichi Mizumaki
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    Ann Noninvasive Electrocardiol 10:16-24. 2005
    ..This study aimed to evaluate dynamic response of QT interval to transient changes in R-R interval during vasovagal syncope (VVS) induced by head-up tilt test...
  62. ncbi request reprint Maintenance of sinus rhythm and recovery of atrial mechanical function after cardioversion with bepridil or in combination with aprindine in long-lasting persistent atrial fibrillation
    Akira Fujiki
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Circ J 68:834-9. 2004
    ..Bepridil alone or in combination with aprindine is effective for termination of persistent AF...
  63. ncbi request reprint Rate control and quality of life in patients with permanent atrial fibrillation: the Quality of Life and Atrial Fibrillation (QOLAF) Study
    Takayuki Tsuneda
    The Second Department of Internal Medicine, University of Toyama, Japan
    Circ J 70:965-70. 2006
    ..The present study aimed to determine whether quality of life (QOL) in permanent atrial fibrillation (AF) patients would be improved by monotherapy with beta-blocker (BB) or calcium antagonist (CAA) as compared with digitalis...
  64. ncbi request reprint Repolarization dynamics in patients with idiopathic ventricular fibrillation: pharmacological therapy with bepridil and disopyramide
    Masataka Sugao
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Pharmacol 45:545-9. 2005
    ..Not only J wave and ST elevation but also shorter QT intervals at slower heart rates may represent an electrophysiological substrate for development of VF episodes in these specific IVF patients...
  65. ncbi request reprint Brief episode of myocardial ischemia before prolonged ischemia attenuates cardiac sympathetic nerve injury
    Teruo Nakadate
    The Second Department of Internal Medicine, University of Toyama, School of Medicine, Toyama, Japan
    Circ J 70:919-25. 2006
    ..Brief ischemia inhibits the sympathetic neural release of norepinephrine (NE) during subsequent sustained ischemia. However, whether it can attenuate the neural function after sustained ischemia remains unknown...
  66. ncbi request reprint Pharmacological cardioversion of persistent atrial fibrillation with and without a history of drug-resistant paroxysmal atrial fibrillation
    Akira Fujiki
    The Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, Japan
    Circ J 70:1138-41. 2006
    ..Whether a history of drug-resistant paroxysmal AF (PAF) would affect the outcome of pharmacological conversion of persistent AF by bepridil or in combination with aprindine was evaluated in the present study...
  67. ncbi request reprint The Japan Thrombosis Registry for Atrial Fibrillation, Coronary or Cerebrovascular Events (J-TRACE): a nation-wide, prospective large cohort study; the study design
    Hideki Origasa
    Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194, Japan
    Circ J 72:991-7. 2008
    ....
  68. doi request reprint Relation of the severity of mitral regurgitation to thromboembolic risk in patients with atrial fibrillation
    Nobuyuki Fukuda
    The Second Department of Internal Medicine, University of Toyama, Japan
    Int J Cardiol 146:197-201. 2011
    ..Although mitral regurgitation (MR) could be protective against left atrial (LA) blood stasis, the relationship between the severity of MR and thromboembolic risk has not been clarified in patients with AF...
  69. ncbi request reprint Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte/macrophage infiltration in the heart of DOCA/salt hypertensive rats
    Kazuhiro Ishimaru
    Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    J Cardiovasc Pharmacol 50:187-94. 2007
    ....
  70. ncbi request reprint Early administration of fluvastatin, but not at the onset of ischemia or reperfusion, attenuates myocardial ischemia-reperfusion injury through the nitric oxide pathway rather than its antioxidant property
    Akira Matsuki
    Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, Sugitani, Toyama, Japan
    Circ J 70:1643-9. 2006
    ..Fluvastatin (FV) has a potent free radical scavenging action, but it is unclear whether the timing of FV administration could affect its cardioprotective effect or if the antioxidant property of FV might attenuate IR injury...
  71. doi request reprint Investigation of optimal anticoagulation strategy for stroke prevention in Japanese patients with atrial fibrillation--the J-RHYTHM Registry study design
    Hirotsugu Atarashi
    Department of Internal Medicine, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan
    J Cardiol 57:95-9. 2011
    ..In order to prevent stroke in atrial fibrillation (AF) lower international normalized ratios (INR) (1.6-2.6) were recommended for elderly Japanese patients, but only one clinical study supported this recommendation...
  72. doi request reprint Narrow QRS ventricular tachycardia from the posterior mitral annulus without involvement of the His-Purkinje system in a patient with prior inferior myocardial infarction
    Tamotsu Sakamoto
    Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930 0194, Japan
    Heart Vessels 25:170-3. 2010
    ..Synchronized excitation of both ventricles from the posterior infarcted mitral annulus in this patient may make the QRS width during VT narrow, without involvement of the His-Purkinje system...
  73. pmc Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action
    Mototsugu Takashima
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes 59:1608-15. 2010
    ....
  74. doi request reprint Circadian changes in autonomic function in conscious rats with heart failure: effects of amiodarone on sympathetic surge
    Takashi Ohori
    The Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Auton Neurosci 159:20-5. 2011
    ..Our experimental system could detect sympathetic surge in conscious rats. Amiodarone suppressed the sympathetic surge, which could explain, at least in part, beneficial effects of amiodarone in patients with CHF...
  75. ncbi request reprint Significant impairment of left atrial function in patients with cardioembolic stroke caused by paroxysmal atrial fibrillation
    Yoshiharu Taguchi
    Department of Neurology at Toyama University Hospital, Toyama, Japan
    Intern Med 49:1727-32. 2010
    ..The present study examined the differences in echocardiographic findings between patients with CE caused by Paf (the Paf-CE group) and those with non-cardiogenic embolic ischemic stroke (the Non-CE group)...
  76. ncbi request reprint Repolarization abnormality in idiopathic ventricular fibrillation: assessment using 24-hour QT-RR and QaT-RR relationships
    Akira Fujiki
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    J Cardiovasc Electrophysiol 15:59-63. 2004
    ..We hypothesized that IVF patients have unique repolarization dynamics related to a reduced fast Na current and a prominent transient outward current...
  77. ncbi request reprint Parametric system identification of arterial baroreflex with random perturbation of blood pressure in normal subjects
    Kunihiro Yamada
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Cardiovasc Pharmacol 42:S11-3. 2003
    ..This method would potentially be of great use in helping us gain insights into a closed-loop system of complex and dynamic cardiovascular regulation in humans...
  78. doi request reprint Relation of left atrial blood stasis to clinical risk factors in atrial fibrillation
    Kazumasa Ohara
    The Second Department of Internal Medicine University of Toyama, Toyama, Sugitani, Toyama, Japan
    Int J Cardiol 132:210-5. 2009
    ....
  79. ncbi request reprint Bepridil reverses atrial electrical remodeling and L-type calcium channel downregulation in a canine model of persistent atrial tachycardia
    Kunihiro Nishida
    Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan
    J Cardiovasc Electrophysiol 18:765-72. 2007
    ..This study tested whether bepridil, a multichannel blocker, would reverse electrical remodeling induced by persistent atrial tachycardia...
  80. doi request reprint Junctional rhythm associated with ventriculoatrial block during slow pathway ablation in atypical atrioventricular nodal re-entrant tachycardia
    Akira Fujiki
    The Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Europace 10:982-7. 2008
    ..We assessed responses to slow pathway ablation with respect to the appearance of ventriculoatrial (VA) block during junctional rhythm in both typical and atypical types of atrioventricular nodal re-entrant tachycardia (AVNRT)...
  81. ncbi request reprint Atorvastatin-induced changes in plasma coenzyme q10 and brain natriuretic peptide in patients with coronary artery disease
    Takayuki Suzuki
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama, Toyama, Japan
    Int Heart J 49:423-33. 2008
    ..However, ATO-induced decreases in CoQ10 might not increase oxidative stress...
  82. ncbi request reprint Usefulness and safety of bepridil in converting persistent atrial fibrillation to sinus rhythm
    Akira Fujiki
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Am J Cardiol 92:472-5. 2003
    ..Bepridil is effective and safe for terminating long-lasting persistent AF...
  83. ncbi request reprint Double potentials at successful catheter ablation site of left-sided retrograde accessory pathway: mitral isthmus block or conduction through coronary sinus musculature
    Akira Fujiki
    The Second Department of Internal Medicine, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Int J Cardiol 117:90-6. 2007
    ..We studied three patients who had orthodromic atrioventricular reentrant tachycardia (AVRT) using left lateral accessory pathway (AP), with difficulty in identifying the earliest site of retrograde atrial activation...
  84. ncbi request reprint The effects of light on sex determination in gametophytes of the fern Ceratopteris richardii
    Hiroyuki Kamachi
    Graduate School of Science and Engineering, University of Toyama, 3190 Gofuku, Toyama 930 8555, Japan
    J Plant Res 120:629-34. 2007
    ..The results of experiments with a photomorphogenic mutant also suggested that phytochrome may be involved in the action of red light...
  85. ncbi request reprint Pharmacological cardioversion of long-lasting atrial fibrillation
    Akira Fujiki
    The Second Department of Internal Medicine, Faculty of Medicine, Toyama University, Toyama, Japan
    Circ J 71:A69-74. 2007
    ..Although the precise mechanism of cardioversion by bepridil is not clear, reversal of the remodeled atria may play an important role...
  86. doi request reprint Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus
    Taizo Nakagawa
    Second Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Sciences for Research, University ofToyama, and Fujikoshi Hospital, 2630, Sugitani, Toyama 930 0194, Japan
    Nephrol Dial Transplant 26:458-68. 2011
    ..In contrast to the well-established role of PDGFR-β in the development of kidney glomerulus, its role in adult kidney glomerulus remains controversial...
  87. doi request reprint Deficiency of testosterone associates with the substrate of atrial fibrillation in the rat model
    Takayuki Tsuneda
    The Second Department of Internal Medicine, University of Toyama, Toyama, Japan
    J Cardiovasc Electrophysiol 20:1055-60. 2009
    ..Since the prevalence of atrial fibrillation (AF) increases progressively with aging, especially in men, we hypothesized that testosterone might affect the occurrence of AF...
  88. doi request reprint Impact of sleeping position on central sleep apnea/Cheyne-Stokes respiration in patients with heart failure
    Shuji Joho
    Second Department of Internal Medicine, Toyama University Hospital, Toyama, Japan
    Sleep Med 11:143-8. 2010
    ..The present study determines the influence of sleeping position on central sleep apnea (CSA) in patients with heart failure (HF)...
  89. ncbi request reprint [Brugada syndrome occurring in an identical twin: a case report]
    Masao Sakabe
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Faculty of Medicine, Sugitani 2630, Toyama, Toyama 930 0194
    J Cardiol 40:111-5. 2002
    ..Although SCN5A mutation is considered to be associated with Brugada syndrome, the present results suggest that the genetic factor is not the only factor responsible for the pathogenesis of Brugada syndrome...
  90. ncbi request reprint Proportion and prognosis of healthy people with coved or saddle-back type ST segment elevation in the right precordial leads during 10 years follow-up
    Masao Sakabe
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Eur Heart J 24:1488-93. 2003
    ..The aim of this study was to investigate long-term proportion and prognosis of healthy subjects with right precordial ST segment elevation without family history of sudden death...
  91. ncbi request reprint Angiotensin-converting enzyme-gene polymorphism is associated with collagen I synthesis and QT dispersion in essential hypertension
    Toru Takahashi
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Hypertens 21:985-91. 2003
    ..This study tested the hypothesis that abnormal QT dispersion, an indicator of arrhythmogenic risk, is associated with angiotensin-converting enzyme (ACE) gene polymorphism and abnormalities of collagen metabolism...
  92. ncbi request reprint Relation between transverse conduction capability and the anatomy of the crista terminalis in patients with atrial flutter and atrial fibrillation: analysis by intracardiac echocardiography
    Koichi Mizumaki
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Circ J 66:1113-8. 2002
    ..05). Therefore, the transverse conduction block of CT was more likely to occur in a thick CT. A limited transverse conduction capability of the CT is related to its thickness and might contribute to the development of typical AFL...
  93. ncbi request reprint Principles of medical management of atrial fibrillation: rhythm control versus rate control
    Hiroshi Inoue
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama
    Intern Med 43:162-3. 2004
  94. ncbi request reprint [Dual atrioventricular nodal pathways]
    Tamotsu Sakamoto
    Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama
    Nippon Rinsho . 2007
  95. ncbi request reprint Role of fibrillation cycle length in spontaneous and drug-induced termination of human atrial fibrillation
    Akira Fujiki
    The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Circ J 67:391-5. 2003
    ..Spontaneous termination in the morning may be caused by an abrupt increase in FCL related to vagolytic autonomic balance...
  96. ncbi request reprint Novel LAMP-2 mutation in a family with Danon disease presenting with hypertrophic cardiomyopathy
    Nobuhiro Dougu
    Department of Neurology, Toyama University Hospital, Toyama University Hospital, Toyama, Japan
    Circ J 73:376-80. 2009
    ..573delA) in exon 5. The 2 affected sisters were also heterozygous for the same mutation. Functional analyses of this novel LAMP2 mutation are mandatory...
  97. ncbi request reprint Cardiac sympathetic denervation modulates the sympathoexcitatory response to acute myocardial ischemia
    Shuji Joho
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Am Coll Cardiol 39:436-42. 2002
    ..This study was designed to elucidate the influence of cardiac sympathetic denervation on the sympathoexcitatory response to acute myocardial ischemia during balloon coronary occlusion (BCO) in humans...
  98. ncbi request reprint Dose-response effect of flecainide in patients with symptomatic paroxysmal atrial fibrillation and/or flutter monitored with trans-telephonic electrocardiography: a multicenter, placebo-controlled, double-blind trial
    Hirotsugu Atarashi
    Department of Internal Medicine, Nippon Medical School, Tama Nagayama Hospital, Japan
    Circ J 71:294-300. 2007
    ....
  99. ncbi request reprint Disparate force-frequency effects of pimobendan and dobutamine in conscious dogs with tachycardia-induced cardiomyopathy
    Shuji Joho
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Card Fail 8:423-30. 2002
    ..This study was designed to examine how a calcium sensitizer, pimobendan, affected a force-frequency response (FFR) as compared to the beta-adrenergic agonist dobutamine...
  100. ncbi request reprint [Electrocardiographic findings]
    Hidehiko Nagasawa
    Second Department of Internal Medicine, Faculty of Medicine, University of Toyama
    Nihon Rinsho 64:176-80. 2006
  101. ncbi request reprint Effects of long-term renal sympathetic denervation on heart failure after myocardial infarction in rats
    Takashi Nozawa
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan
    Heart Vessels 16:51-6. 2002
    ..Increased renal sympathetic nerve activity might contribute to the progression of heart failure after MI...