Reiko Inagi

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint The role of glyoxalase system in renal hypoxia
    Reiko Inagi
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Adv Exp Med Biol 662:49-55. 2010
  2. pmc Preconditioning with endoplasmic reticulum stress ameliorates mesangioproliferative glomerulonephritis
    Reiko Inagi
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1, Hongo Bunkyo ku, Tokyo 113 8655, Japan
    J Am Soc Nephrol 19:915-22. 2008
  3. doi request reprint Endoplasmic reticulum stress in the kidney as a novel mediator of kidney injury
    Reiko Inagi
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Nephron Exp Nephrol 112:e1-9. 2009
  4. ncbi request reprint Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis
    Tetsuhiro Tanaka
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Kidney Int 68:2714-25. 2005
  5. doi request reprint Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats
    Takanori Kumagai
    Div of Nephrology and Endocrinology, Univ of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Renal Physiol 296:F912-21. 2009
  6. doi request reprint Metallothionein is upregulated by hypoxia and stabilizes hypoxia-inducible factor in the kidney
    Ichiro Kojima
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Kidney Int 75:268-77. 2009
  7. doi request reprint Cytoglobin, a novel globin, plays an antifibrotic role in the kidney
    Imari Mimura
    Div of Nephrology and Endocrinology, Univ of Tokyo School of Medicine, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Am J Physiol Renal Physiol 299:F1120-33. 2010
  8. ncbi request reprint Hypoxia-inducible factor modulates tubular cell survival in cisplatin nephrotoxicity
    Tetsuhiro Tanaka
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Bunkyo ku, Tokyo, Japan
    Am J Physiol Renal Physiol 289:F1123-33. 2005
  9. ncbi request reprint In a type 2 diabetic nephropathy rat model, the improvement of obesity by a low calorie diet reduces oxidative/carbonyl stress and prevents diabetic nephropathy
    Masaomi Nangaku
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo
    Nephrol Dial Transplant 20:2661-9. 2005
  10. ncbi request reprint Erythropoietin induces heme oxygenase-1 expression and attenuates oxidative stress
    Pisut Katavetin
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 359:928-34. 2007

Collaborators

Detail Information

Publications61

  1. doi request reprint The role of glyoxalase system in renal hypoxia
    Reiko Inagi
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Adv Exp Med Biol 662:49-55. 2010
    ..In conclusion, glyoxalase I has renoprotective effects in renal hypoxia such as I/R injury via a reduction in cytotoxic MG level in tubular cells...
  2. pmc Preconditioning with endoplasmic reticulum stress ameliorates mesangioproliferative glomerulonephritis
    Reiko Inagi
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1, Hongo Bunkyo ku, Tokyo 113 8655, Japan
    J Am Soc Nephrol 19:915-22. 2008
    ..These findings suggest the possibility of therapeutic approaches targeting ER stress in mesangioproliferative glomerulonephritis...
  3. doi request reprint Endoplasmic reticulum stress in the kidney as a novel mediator of kidney injury
    Reiko Inagi
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Nephron Exp Nephrol 112:e1-9. 2009
    ..In tubules, apoptosis resulting from epithelial cell damage is caused, at least in part, by the proapoptotic UPR. These findings emphasize the possibility of the development of novel renoprotective drugs which target ER stress...
  4. ncbi request reprint Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis
    Tetsuhiro Tanaka
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Kidney Int 68:2714-25. 2005
    ..Here, we tested the hypothesis that cobalt administration not only attenuates acute ischemic insult, but also ameliorates tubulointerstitial injury secondary to chronic hypoxia...
  5. doi request reprint Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats
    Takanori Kumagai
    Div of Nephrology and Endocrinology, Univ of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Renal Physiol 296:F912-21. 2009
    ..In conclusion, glyoxalase I exerts renoprotective effects in renal I/R injury via a reduction in MG accumulation in tubular cells...
  6. doi request reprint Metallothionein is upregulated by hypoxia and stabilizes hypoxia-inducible factor in the kidney
    Ichiro Kojima
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Kidney Int 75:268-77. 2009
    ..Our study shows that upregulation of metallothionein expression by hypoxia activates the HIF-HRE system through the ERK/mTOR pathway and may be a novel defense against hypoxia...
  7. doi request reprint Cytoglobin, a novel globin, plays an antifibrotic role in the kidney
    Imari Mimura
    Div of Nephrology and Endocrinology, Univ of Tokyo School of Medicine, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Am J Physiol Renal Physiol 299:F1120-33. 2010
    ..Cygb might represent a good therapeutic target in chronic kidney disease...
  8. ncbi request reprint Hypoxia-inducible factor modulates tubular cell survival in cisplatin nephrotoxicity
    Tetsuhiro Tanaka
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Bunkyo ku, Tokyo, Japan
    Am J Physiol Renal Physiol 289:F1123-33. 2005
    ..A possibility was suggested that activation of HIF-1 could be a new promising therapeutic target for hypoxic renal diseases...
  9. ncbi request reprint In a type 2 diabetic nephropathy rat model, the improvement of obesity by a low calorie diet reduces oxidative/carbonyl stress and prevents diabetic nephropathy
    Masaomi Nangaku
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo
    Nephrol Dial Transplant 20:2661-9. 2005
    ..The present study has been undertaken to unravel the critical factors involved in the progression of diabetic nephropathy (DN)...
  10. ncbi request reprint Erythropoietin induces heme oxygenase-1 expression and attenuates oxidative stress
    Pisut Katavetin
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 359:928-34. 2007
    ..This renoprotection was associated with up-regulation of HO-1 in the kidney. In conclusion, EPO-induced HO-1 expression is likely to provide cytoprotection against oxidative stress...
  11. pmc Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells
    Shiyo Muratsu-Ikeda
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    PLoS ONE 7:e41462. 2012
    ..While the pathophysiological contribution of microRNAs (miRNA) to renal damage has also been highlighted, the effect of miRNA on renal damage under oxidative and ER stresses conditions remains elusive...
  12. ncbi request reprint Evidence of tubular hypoxia in the early phase in the remnant kidney model
    Krissanapong Manotham
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 15:1277-88. 2004
    ..The initial hypoxia in this model was dependent on activation of the renin-angiotensin system and hemodynamic alterations after nephron loss...
  13. doi request reprint Contribution of T lymphocytes to rat renal ischemia/reperfusion injury
    Eisei Noiri
    Department of Nephrology and Endocrinology 107 Lab, Hemodialysis and Apheresis, University Hospital, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Clin Exp Nephrol 13:25-32. 2009
    ..This study aimed to elucidate the early involvement of T lymphocytes in renal ischemia/reperfusion injury...
  14. pmc Hypoxia in renal disease with proteinuria and/or glomerular hypertension
    Tetsuhiro Tanaka
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Bunkyo ku, Tokyo, Japan
    Am J Pathol 165:1979-92. 2004
    ..We propose here a possible pathological tie between chronic tubulointerstitial hypoxia and progressive glomerular diseases...
  15. pmc Glyoxalase I retards renal senescence
    Yoichiro Ikeda
    Division of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Am J Pathol 179:2810-21. 2011
    ..These findings indicate that GLO1 ameliorates carbonyl stress to retard renal senescence...
  16. ncbi request reprint Albumin suppresses vascular endothelial growth factor via alteration of hypoxia-inducible factor/hypoxia-responsive element pathway
    Pisut Katavetin
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Biochem Biophys Res Commun 367:305-10. 2008
    ..Further, albumin did not change HIF mRNA levels. Our data, for the first time, suggest a clear 'link' between proteinuria and hypoxia, the two principal pathogenic factors for CKD progression...
  17. ncbi request reprint High glucose blunts vascular endothelial growth factor response to hypoxia via the oxidative stress-regulated hypoxia-inducible factor/hypoxia-responsible element pathway
    Pisut Katavetin
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Am Soc Nephrol 17:1405-13. 2006
    ..In conclusion, high glucose blunts VEGF response to hypoxia in IRPTC. This effect is mediated by the oxidative stress-regulated HIF-HRE pathway...
  18. pmc Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions
    Hiroshi Nishi
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Am J Pathol 178:128-39. 2011
    ..These findings show for the first time, to our knowledge, that Cygb serves as a defensive mechanism against oxidative stress both in vitro and in vivo...
  19. ncbi request reprint Receptor-independent intracellular radical scavenging activity of an angiotensin II receptor blocker
    Jing Shao
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    J Hypertens 25:1643-9. 2007
    ..We investigated the receptor-independent protective role of an ARB using primary-cultured mesangial cells from angiotensin II receptor 1 knockout or wild-type mice and a highly lipophilic ARB, telmisartan...
  20. ncbi request reprint Imbalance of T-cell subsets in angiotensin II-infused hypertensive rats with kidney injury
    Jing Shao
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hypertension 42:31-8. 2003
    ..The imbalance of Th subsets was associated with hypertensive kidney injury induced by Ang II. Some of the beneficial effects of ARBs might be explained by their immunomodulatory reactions...
  21. pmc Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression
    Nobuaki Eto
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Am J Pathol 174:1553-63. 2009
    ..The results of this study suggest that MAP3K6 regulates VEGF expression in both normoxia and hypoxia, and that regulation of VEGF by MAP3K6 may play a crucial role in both angiogenesis and tumorigenesis...
  22. doi request reprint Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner
    Chih Kang Chiang
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Japan
    Lab Invest 91:1564-71. 2011
    ....
  23. ncbi request reprint A biologic role of HIF-1 in the renal medulla
    Krissanapong Manotham
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Kidney Int 67:1428-39. 2005
    ..However, a biologic role of HIF-1 in the medulla of the kidney, which is considered perpetually hypoxic under physiologic conditions due to its unique circulation, remains to be elucidated...
  24. doi request reprint Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endoplasmic reticulum stress
    Takahisa Kawakami
    University of Tokyo School of Medicine, Japan
    Am J Physiol Renal Physiol 299:F568-76. 2010
    ..These are possible targets for suppressing progression of CKD...
  25. ncbi request reprint Hypoperfusion of peritubular capillaries induces chronic hypoxia before progression of tubulointerstitial injury in a progressive model of rat glomerulonephritis
    Makiko Matsumoto
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Am Soc Nephrol 15:1574-81. 2004
    ..In conclusion, stagnation of blood flow in peritubular capillaries induced chronic hypoxia at an early stage in this model, which was followed by progressive tubulointerstitial injury and a loss of peritubular capillaries...
  26. ncbi request reprint Protection of endothelial cells by dextran sulfate in rats with thrombotic microangiopathy
    Nobuaki Eto
    Division of Nephrology and Endocrinology, University of Tokyo, School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Am Soc Nephrol 16:2997-3005. 2005
    ..This protection may be mediated by DXS's binding directly to the surface of glomerular endothelium and amelioration of coagulation, complement activation, and cellular matrix loss...
  27. ncbi request reprint Hypoxia and expression of hypoxia-inducible factor in the aging kidney
    Tetsuhiro Tanaka
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Gerontol A Biol Sci Med Sci 61:795-805. 2006
    ..These findings point to the involvement of hypoxia and highlight the pathological relevance of HIF and its target genes in the aging kidney...
  28. ncbi request reprint Chronic hypoxia aggravates renal injury via suppression of Cu/Zn-SOD: a proteomic analysis
    Daisuke Son
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Renal Physiol 294:F62-72. 2008
    ..This study, for the first time, uncovered maladaptive suppression of Cu/Zn-SOD as a mediator of a vicious cycle of oxidative stress and subsequent renal injury induced by chronic hypoxia...
  29. ncbi request reprint Blockade of calcium influx through L-type calcium channels attenuates mitochondrial injury and apoptosis in hypoxic renal tubular cells
    Tetsuhiro Tanaka
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1, Hongo, Bunkyo ku, Tokyo, Japan
    J Am Soc Nephrol 15:2320-33. 2004
    ....
  30. ncbi request reprint Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney
    Ichiro Kojima
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Am Soc Nephrol 18:1218-26. 2007
    ..These results suggest that HIF-2alpha in the endothelium has a protective role against ischemia of the kidney via amelioration of oxidative stress...
  31. pmc Hemoglobin is expressed by mesangial cells and reduces oxidant stress
    Hiroshi Nishi
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Am Soc Nephrol 19:1500-8. 2008
    ..In summary, Hb is expressed by rat mesangial cells, and its potential functions may include antioxidative defense...
  32. ncbi request reprint Accelerated glomerular injury in hemi-nephrectomized transgenic mice of mesangial cell-predominant serpin, megsin
    Hiroshi Onogi
    Preventure Program, Office of Technology Transfer, Japan Science and Technology Cooperation, Tokyo, Japan
    Nephron Exp Nephrol 96:e127-33. 2004
    ..Megsin has thus a biologically relevant influence on the development of glomerular damage. The hemi-nephrectomized model of this transgenic mouse might serve as a tool to investigate the mechanisms of glomerular disease...
  33. ncbi request reprint Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4
    Chih Kang Chiang
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Am J Physiol Cell Physiol 304:C342-53. 2013
    ..This effect is mediated by suppression of EPO 3'-enhancer activity via ATF4 without any direct effect on HIF, indicating that UPR contributes to oxygen-sensing regulation of EPO...
  34. doi request reprint Pathophysiological role of the glyoxalase system in renal hypoxic injury
    Takanori Kumagai
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Ann N Y Acad Sci 1126:265-7. 2008
    ..These results demonstrate that GLO I has renoprotective effects in I/R injury via reduction of protein modification by MG...
  35. doi request reprint Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells
    Takahisa Kawakami
    University of Tokyo School of Medicine, Japan
    Nephrol Dial Transplant 24:2665-72. 2009
    ..However, little information about autophagy in renal tubular cells is available. We investigated the relationship of autophagy with endoplasmic reticulum (ER) stress in proximal tubular cells...
  36. ncbi request reprint Angiotensin-induced hypoxia in the kidney: functional and structural changes of the renal circulation
    Masaomi Nangaku
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Adv Exp Med Biol 618:85-99. 2007
    ..This has given hope for the development of novel therapeutic approaches against hypoxia in the kidney...
  37. doi request reprint Sperm-associated antigen 4, a novel hypoxia-inducible factor 1 target, regulates cytokinesis, and its expression correlates with the prognosis of renal cell carcinoma
    Kumi Shoji
    Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan
    Am J Pathol 182:2191-203. 2013
    ..This defensive mechanism may promote survival of cancer cells under hypoxic conditions, thus leading to poor prognosis...
  38. ncbi request reprint Hypoxia-induced apoptosis in cultured glomerular endothelial cells: involvement of mitochondrial pathways
    Tetsuhiro Tanaka
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Kidney Int 64:2020-32. 2003
    ..Accumulating evidence has shown that failure to maintain the microcirculation leads to irreversible glomerular injury and glomerular sclerosis. In this regard, the behavior of endothelial cells in a hypoxic milieu is of interest...
  39. ncbi request reprint Transdifferentiation of cultured tubular cells induced by hypoxia
    Krissanapong Manotham
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Kidney Int 65:871-80. 2004
    ..However, the role(s) of hypoxia, which is involved in progressive kidney disease, on tubular EMT remains unclear...
  40. ncbi request reprint Anti-hypertensive agents inhibit in vivo the formation of advanced glycation end products and improve renal damage in a type 2 diabetic nephropathy rat model
    Masaomi Nangaku
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 14:1212-22. 2003
    ..It is concluded that AGE inhibition should be included in the therapeutic strategy of DN...
  41. doi request reprint Endoplasmic reticulum stress as a progression factor for kidney injury
    Reiko Inagi
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo Bunkyo ku, Tokyo 113 8655, Japan
    Curr Opin Pharmacol 10:156-65. 2010
    ..These therapeutic approaches may act by breaking the vicious cycle of oxidative stress, hypoxia, and ER stress...
  42. ncbi request reprint Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation
    Airi Jo-Watanabe
    Division of Nephrology and Endocrinology, Tokyo, Japan
    Aging Cell 13:519-28. 2014
    ..Our study demonstrates that blunting glycative stress prevents the long-term impact of endothelial dysfunction on vascular aging...
  43. ncbi request reprint ET(B) receptor protects the tubulointerstitium in experimental thrombotic microangiopathy
    Masaomi Nangaku
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Kidney Int 62:922-8. 2002
    ..The endothelin ET(B) receptor has been shown to mediate both endothelial cell proliferation and vasodilation, and we therefore hypothesized that blockade of this receptor might promote more severe injury in this model...
  44. doi request reprint Hypoxia and hypoxia-inducible factor in renal disease
    Masaomi Nangaku
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Nephron Exp Nephrol 110:e1-7. 2008
    ..Because HIF is activated only to suboptimal levels in various pathogenic states, therapeutic activation holds promise as a novel and effective approach to the future care of end-stage renal disease...
  45. doi request reprint Inhibitors of advanced glycation and endoplasmic reticulum stress
    Reiko Inagi
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Methods Enzymol 491:361-80. 2011
    ..In this chapter, I focus on the link between advanced glycation and ER stress, and the potential use of inhibitors of AGE formation as modulators of ER stress...
  46. doi request reprint Glomerular diseases: genetic causes and future therapeutics
    Chih Kang Chiang
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo 113 8655, Japan
    Nat Rev Nephrol 6:539-54. 2010
    ..Discoveries of mutations in a range of genes have provided new insights into the mechanisms of glomerular disease. In this Review, we summarize recent progress in the genetics and therapeutics of a number of glomerular diseases...
  47. ncbi request reprint Proteostasis in endoplasmic reticulum-new mechanisms in kidney disease
    Reiko Inagi
    Division of Chronic Kidney Disease Pathophysiology, The University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nat Rev Nephrol 10:369-78. 2014
    ....
  48. ncbi request reprint Novel serpinopathy in rat kidney and pancreas induced by overexpression of megsin
    Reiko Inagi
    Molecular and Cellular Nephrology, Institute of Medical Sciences, Tokai University, Kanagawa, Japan
    J Am Soc Nephrol 16:1339-49. 2005
    ..This model of serpinopathy is the first to involve the kidney and the pancreas...
  49. ncbi request reprint Serpinopathy and endoplasmic reticulum stress
    Toshio Miyata
    Institute of Medical Sciences and Department of Medicine, Tokai University School of Medicine, Kanagawa, 259 1193, Japan
    Med Mol Morphol 38:73-8. 2005
    ..Further research for ER structure and function may open new exciting prospects in the pathology of human renal diseases...
  50. ncbi request reprint Renoprotective properties of angiotensin receptor blockers beyond blood pressure lowering
    Yuko Izuhara
    Institute of Medical Sciences and Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan
    J Am Soc Nephrol 16:3631-41. 2005
    ..These benefits of ARB may contribute to the renoprotection observed beyond BP lowering...
  51. ncbi request reprint Involvement of endoplasmic reticulum (ER) stress in podocyte injury induced by excessive protein accumulation
    Reiko Inagi
    Molecular and Cellular Nephrology, Institute of Medical Sciences, Tokai University, Kanagawa, Japan
    Kidney Int 68:2639-50. 2005
    ..Here we investigate expression of ER stress proteins in cultured rat podocytes as well as in our recently developed animal model of abnormal protein retention within the ER of podocytes (i.e., megsin transgenic rat)...
  52. ncbi request reprint A rat model of human FENIB (familial encephalopathy with neuroserpin inclusion bodies)
    Katsura Takano
    Department of Neuroanatomy, Kanazawa University Medical School, Ishikawa, Japan
    Biochem Biophys Res Commun 346:1040-7. 2006
    ..Tg meg rats provide a novel model of FENIB, where accumulation of serpins in the ER induces selective dysfunction/loss of specific neuronal populations...
  53. ncbi request reprint Synergistic contributions of carbonyl stress and megsin in diabetic nephropathy
    Reiko Inagi
    Institute of Medical Sciences, Tokai University School of Medicine, Kanagawa 259 1193, Japan
    Ann N Y Acad Sci 1043:605-8. 2005
    ..Megsin and AGEs are suitable targets for new drugs of diabetic nephropathy and for the development of appropriate animal models of diabetic nephropathy...
  54. ncbi request reprint Oxidative stress in cardiovascular disease: a new avenue toward future therapeutic approaches
    Reiko Inagi
    Institute of Medical Sciences, Tokai University School of Medicine, Bohseidai, Isehara Kanagawa 259 1193, Japan
    Recent Pat Cardiovasc Drug Discov 1:151-9. 2006
    ..In this review, the current advances will be highlighted in development of novel anti-oxidative therapeutic approaches against cardiovascular diseases...
  55. ncbi request reprint Efficient in vitro lowering of carbonyl stress by the glyoxalase system in conventional glucose peritoneal dialysis fluid
    Reiko Inagi
    Molecular and Cellular Nephrology, Institute of Medical Sciences and Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Kidney Int 62:679-87. 2002
    ..The present study utilized the glyoxalase I (GLO I) system as a new approach to lower in vitro the peritoneal fluid content of RCOs such as methylglyoxal (MGO), glyoxal (GO) and 3-deoxyglucosone (3-DG)...
  56. ncbi request reprint Mesangial cell-predominant gene, megsin
    Reiko Inagi
    Institute of Medical Sciences and Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan
    Nephrol Dial Transplant 17:32-3. 2002
    ..Genetic manipulation of megsin engenders two elementary mesangial lesions, mesangial expansion and an increase in the number of mesangial cells...
  57. ncbi request reprint [Post-genome research on megsin, a kidney-specific serpin gene]
    Naoto Tominaga
    Institute of Medical Sciences, Tokai University
    Nihon Rinsho 64:371-4. 2006
  58. ncbi request reprint Mesangial cell-predominant functional gene, megsin
    Reiko Inagi
    Institute of Medical Sciences, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Clin Exp Nephrol 7:87-92. 2003
    ..Identification of the exact biological functions and target proteases of megsin will lead us to develop novel therapeutic approaches to glomerular diseases...
  59. ncbi request reprint A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice
    Reiko Inagi
    Institute of Medical Sciences and Division of Nephrology, Hypertension and Metabolism, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    Diabetes 55:356-66. 2006
    ..This multiple hit approach is of interest in consideration of the sequential events during development of diabetic nephropathy...
  60. pmc Overexpression of the serpin megsin induces progressive mesangial cell proliferation and expansion
    Toshio Miyata
    Molecular and Cellular Nephrology, Institute of Medical Sciences and Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan
    J Clin Invest 109:585-93. 2002
    ..Megsin therefore exerts a biologically relevant influence on mesangial function, and on the mesangial microenvironment, such that simple overexpression of this endogenous serpin engenders elementary mesangial lesions...
  61. ncbi request reprint [Progress in nephrology during this year: Basic research for kidney diseases]
    Masaomi Nangaku
    Nihon Jinzo Gakkai Shi 50:5-10. 2008