Yasushi Imai

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Left cervical aortic arch with aortic coarctation and saccular aneurysm
    Y Imai
    The Third Department of Internal Medicine, University of Tokyo, Japan
    Jpn Circ J 64:544-6. 2000
  2. ncbi request reprint Genetic analysis in a patient with recurrent cardiac myxoma and endocrinopathy
    Yasushi Imai
    Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan
    Circ J 69:994-5. 2005
  3. ncbi request reprint C-reactive protein induces VCAM-1 gene expression through NF-kappaB activation in vascular endothelial cells
    Daiji Kawanami
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Atherosclerosis 185:39-46. 2006
  4. ncbi request reprint Plasma cystatin C concentration reflects the severity of coronary artery disease in patients without chronic kidney disease
    Arihiro Kiyosue
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Circ J 74:2441-7. 2010
  5. ncbi request reprint Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension
    Yumiko Oishi
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    FASEB J 24:1780-8. 2010
  6. ncbi request reprint Genetic variations of Mrf-2/ARID5B confer risk of coronary atherosclerosis in the Japanese population
    Guoqin Wang
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo ky, Tokyo, Japan
    Int Heart J 49:313-27. 2008
  7. doi request reprint Associations of variations in the MRF2/ARID5B gene with susceptibility to type 2 diabetes in the Japanese population
    Guoqin Wang
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Hum Genet 57:727-33. 2012
  8. pmc Angiotensin II impairs endothelial nitric-oxide synthase bioavailability under free cholesterol-enriched conditions via intracellular free cholesterol-rich membrane microdomains
    Eisuke Amiya
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 288:14497-509. 2013
  9. ncbi request reprint Circulating transforming growth factor β-1 level in Japanese patients with Marfan syndrome
    Naomi Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int Heart J 54:23-6. 2013
  10. ncbi request reprint Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1
    Norihiko Takeda
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Circ Res 95:146-53. 2004

Detail Information

Publications53

  1. ncbi request reprint Left cervical aortic arch with aortic coarctation and saccular aneurysm
    Y Imai
    The Third Department of Internal Medicine, University of Tokyo, Japan
    Jpn Circ J 64:544-6. 2000
    ..The discrepancy in blood pressure diminished after the operation, but antihypertensive medication was continued to satisfactorily control the hypertension...
  2. ncbi request reprint Genetic analysis in a patient with recurrent cardiac myxoma and endocrinopathy
    Yasushi Imai
    Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan
    Circ J 69:994-5. 2005
    ..Although it is the most common, usually benign, cardiac tumor, myxoma can cause a critical clinical situation and thus detecting the PRKAR1A mutation can assist with prognosis...
  3. ncbi request reprint C-reactive protein induces VCAM-1 gene expression through NF-kappaB activation in vascular endothelial cells
    Daiji Kawanami
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Atherosclerosis 185:39-46. 2006
    ..Taken together, our findings suggest that VCAM-1 induction by CRP is mediated by PKC, p38MAPK, tyrosine kinase and the NF-kappaB-dependent signaling pathways in vascular endothelial cells...
  4. ncbi request reprint Plasma cystatin C concentration reflects the severity of coronary artery disease in patients without chronic kidney disease
    Arihiro Kiyosue
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Circ J 74:2441-7. 2010
    ....
  5. ncbi request reprint Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension
    Yumiko Oishi
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    FASEB J 24:1780-8. 2010
    ..These results suggest that a novel signaling and transcription network involving MEF2A and KLF5 plays an important role in the pathogenesis of cardiovascular diseases such as hypertension...
  6. ncbi request reprint Genetic variations of Mrf-2/ARID5B confer risk of coronary atherosclerosis in the Japanese population
    Guoqin Wang
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo ky, Tokyo, Japan
    Int Heart J 49:313-27. 2008
    ..The results implicate possible disease relevance of the polymorphisms in the Mrf-2 gene with susceptibility to CAD. However, a larger scale prospective study is needed to clarify these findings...
  7. doi request reprint Associations of variations in the MRF2/ARID5B gene with susceptibility to type 2 diabetes in the Japanese population
    Guoqin Wang
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Hum Genet 57:727-33. 2012
    ..In conclusion, polymorphisms on the MRF2/ARID5B gene were associated with susceptibility to T2D as well as adiponectin and other clinical factors, which was in a completely concordant way with their associations with CAD...
  8. pmc Angiotensin II impairs endothelial nitric-oxide synthase bioavailability under free cholesterol-enriched conditions via intracellular free cholesterol-rich membrane microdomains
    Eisuke Amiya
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 288:14497-509. 2013
    ..Angiotensin II-induced ROS decreased the bioavailability of eNOS under the FC-enriched condition...
  9. ncbi request reprint Circulating transforming growth factor β-1 level in Japanese patients with Marfan syndrome
    Naomi Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int Heart J 54:23-6. 2013
    ..Circulating TGFβ1 is not a diagnostic and therapeutic marker for Japanese MFS patients, although our findings do not eliminate the possible association of TGFβ with the pathogenesis of MFS...
  10. ncbi request reprint Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1
    Norihiko Takeda
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Circ Res 95:146-53. 2004
    ..Thus, EPAS1 may contribute to the construction of mature vessels by modulating the coordinated expressions of VEGF, Flt-1, Flk-1, and Tie2...
  11. pmc Promoter region-specific histone incorporation by the novel histone chaperone ANP32B and DNA-binding factor KLF5
    Yoshiko Munemasa
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Cell Biol 28:1171-81. 2008
    ....
  12. ncbi request reprint Diagnostic efficacy of coronary CT angiography as a follow-up modality for procedure-related coronary dissection
    Eriko Hasumi
    Department of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan
    Int Heart J 52:240-2. 2011
    ..Thus, coronary CT angiography might be considered as a possible first-line follow-up modality in patients with procedure-related coronary dissection...
  13. ncbi request reprint Altered patterns of gene expression specific to thoracic aortic aneurysms: microarray analysis of surgically resected specimens
    Tsuyoshi Taketani
    Depertment of Cardiovascular Surgery, University of Tokyo Graduate School of Medicine, Hongo, Tokyo, Japan
    Int Heart J 46:265-77. 2005
    ..Investigation of these genes will help clarify the pathogenesis of this disease, and may lead to the discovery of novel therapeutic targets...
  14. ncbi request reprint Radiofrequency catheter ablation of the accessory pathway adversely affected the left ventricular outflow tract pressure gradient in a patient with hypertrophic obstructive cardiomyopathy
    Atsuko Nakayama
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo, Tokyo, Japan
    Int Heart J 54:111-4. 2013
    ..To stabilize the LVOT pressure gradient, he needed additional medications. This case shows that patients with HOCM should be carefully evaluated before making a decision concerning ablation of the accessory pathway...
  15. doi request reprint Depressive symptoms are common and associated with adverse clinical outcomes in heart failure with reduced and preserved ejection fraction
    Naoko Kato
    Department of Cardiovascular Medicine, The University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Cardiol 60:23-30. 2012
    ..We aimed to assess the prevalence of depression, to clarify the impact of depressive symptoms upon clinical outcomes, and to identify factors associated with these symptoms in HF with reduced EF (HFrEF, EF <50%) and HFpEF...
  16. doi request reprint Idiopathic retroperitoneal fibrosis, inflammatory aortic aneurysm, and inflammatory pericarditis--retrospective analysis of 11 case histories
    Aiko Sakamoto
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Cardiol 59:139-46. 2012
    ....
  17. doi request reprint IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension
    Kensuke Tsushima
    Department of Immunology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    FASEB J 25:1531-43. 2011
    ..Thus, our present study reveals a hitherto unrecognized function of IRF3 in cardiac remodeling, providing new insight into the progression of hypertension-induced cardiac pathogenesis...
  18. ncbi request reprint Genetic variations of matrix metalloproteinase-1 and -3 promoter regions and their associations with susceptibility to myocardial infarction in Japanese
    Takefumi Nojiri
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Int J Cardiol 92:181-6. 2003
    ..51 P=0.017, MI group-2). Taken together, the present findings suggest that genetic variations in these MMP genes and especially their haplotype may be useful genetic markers for determining susceptibility to MI in Japanese...
  19. ncbi request reprint Thrombomodulin is a clock-controlled gene in vascular endothelial cells
    Norihiko Takeda
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Biol Chem 282:32561-7. 2007
    ..In conclusion, these data suggest that the peripheral clock in vascular endothelial cells regulates TM gene expression and that the oscillation of TM expression may contribute to the circadian variation of cardiovascular events...
  20. ncbi request reprint DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation
    Go Nishimura
    Department of Cardiovascular Medicine, School of Engineering, The University of Tokyo, Bunkyo, Tokyo 113 8655, Japan
    Dev Cell 11:93-104. 2006
    ..It thus appears deltaEF1 mediates SMC differentiation via interaction with SRF and Smad3 during development and in vascular disease...
  21. doi request reprint VEGF-A induces its negative regulator, soluble form of VEGFR-1, by modulating its alternative splicing
    Tetsuya Saito
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    FEBS Lett 587:2179-85. 2013
    ..The VEGF-A-induced sVEGFR-1 upregulation can operate as a negative feedback system, which if modulated can become a novel therapeutic target for regulating pathological angiogenesis...
  22. doi request reprint Evaluating Japanese patients with the Marfan syndrome using high-throughput microarray-based mutational analysis of fibrillin-1 gene
    Naomi Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Am J Cardiol 108:1801-7. 2011
    ....
  23. ncbi request reprint Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions
    Daiji Kawanami
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Biochem Biophys Res Commun 314:415-9. 2004
    ..Taken together, these results suggest that the balance in the concentrations of adipocytokines such as resistin and adiponectin determines the inflammation status of vasculature, and in turn the progress of atherosclerosis...
  24. ncbi request reprint Development of a pioneering clinical support system utilizing information technology
    Doubun Hayashi
    Department of Pharmacoepidemiology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Jpn Heart J 45:315-24. 2004
    ..We report here these medical achievements as well as technological ones which will play a role in propagating such medical achievements...
  25. ncbi request reprint Impairment of flow-mediated dilation correlates with aortic dilation in patients with Marfan syndrome
    Munenori Takata
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Heart Vessels 29:478-85. 2014
    ..Common atherogenic risks, such as impairment of flow-mediated dilation and smoking status, affected aortic dilation in subjects with Marfan syndrome. ..
  26. ncbi request reprint Intrathoracic impedance monitoring in patients with heart failure: correlation with dehydration and bleeding events
    Kazuo Asada
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Circ J 76:2592-8. 2012
    ..The correlation between intrathoracic impedance and a volume loss event is not known...
  27. doi request reprint Serum levels of IgG4 and soluble interleukin-2 receptor in patients with coronary artery disease
    Aiko Sakamoto
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
    Clin Chim Acta 413:577-81. 2012
    ..We investigated the association between serum concentrations of IgG4 or soluble interleukin-2 receptor (sIL-2R) and coronary artery disease (CAD)...
  28. ncbi request reprint A common Ile 823 Met variant of ATP-binding cassette transporter A1 gene (ABCA1) alters high density lipoprotein cholesterol level in Japanese population
    Tomohiro Harada
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Atherosclerosis 169:105-12. 2003
    ..In this study, we provide evidence that I/M 823 variant, not R/K 219 variant, in ABCA1 is one of the determinants of HDL-C level, suggesting the importance of this gene on lipid metabolism in Japanese...
  29. ncbi request reprint Relationship between renal dysfunction and severity of coronary artery disease in Japanese patients
    Arihiro Kiyosue
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Circ J 74:786-91. 2010
    ..The relationship between renal dysfunction and the severity of coronary artery disease (CAD) was examined...
  30. ncbi request reprint A case of neonatal lupus erythematosus presenting delayed dilated cardiomyopathy with circulating autoantibody to annexin A6
    Yoshinori Seko
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo
    Int Heart J 48:407-15. 2007
    ..The results indicate that inhibition of annexin A6 function may prevent autoantibody-mediated myocardial injury in at least some cases of DCM...
  31. ncbi request reprint Atrial natriuretic peptide inhibits cardiomyocyte hypertrophy through mitogen-activated protein kinase phosphatase-1
    Doubun Hayashi
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 322:310-9. 2004
    ..Our present study suggests that the formation of cardiac hypertrophy is regulated not only by positive but by negative factors in response to hemodynamic load...
  32. ncbi request reprint Manganese superoxide dismutase polymorphism affects the oxidized low-density lipoprotein-induced apoptosis of macrophages and coronary artery disease
    Hajime Fujimoto
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Eur Heart J 29:1267-74. 2008
    ....
  33. doi request reprint Images in cardiovascular medicine. Markedly dilated right heart 17 years after initial treatment repaired by total right ventricular exclusion and total cavopulmonary connection
    Taro Kariya
    Department of Cardiovascular Medicine, University of Tokyo Hospital, Tokyo, Japan
    Circulation 118:e133-5. 2008
  34. ncbi request reprint Early decision for a left ventricular assist device implantation is necessary for patients with modifier A
    Teruhiko Imamura
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Artif Organs 15:301-4. 2012
    ..We would like to emphasize that we should consider implantable left ventricular assist device therapy as soon as possible for those who are assigned modifier A to prevent sudden arrhythmic death...
  35. pmc Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo
    Yuichi Ikeda
    Division of Hematopoietic Factors and Department of Advanced Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 101:10732-7. 2004
    ..Thus, vasorin is a potential therapeutic target for vascular fibroproliferative disorders...
  36. doi request reprint Translation and validation study of the Japanese versions of the Coronary Revascularisation Outcome Questionnaire (CROQ-J)
    Satomi Seki
    Department of Adult Nursing, University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo 113 0033, Japan
    Eur J Cardiovasc Nurs 10:22-30. 2011
    ..The purpose of this study was to develop the Japanese version of the coronary revascularisation outcome questionnaire (CROQ), a disease-specific scale to measure HRQOL before and after coronary revascularisation...
  37. ncbi request reprint Rationale and design of a study to examine lower targets for low-density lipoprotein-cholesterol and blood pressure in coronary artery disease patients
    Ryozo Nagai
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Circ J 72:515-20. 2008
    ....
  38. ncbi request reprint Aortic valve replacement for aortic stenosis caused by alkaptonuria
    Junko Hiroyoshi
    Department of Cardiothoracic Surgery, The University of Tokyo, Faculty of Medicine, Tokyo, Japan
    Ann Thorac Surg 95:1076-9. 2013
    ..Intraoperative findings included ochronosis of a severely calcified pigmented aortic valve along with pigmentation of the intima of the aorta...
  39. ncbi request reprint Carvedilol therapy improved left ventricular function in a patient with arrhythmogenic right ventricular cardiomyopathy
    Yukio Hiroi
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan
    Jpn Heart J 45:169-77. 2004
    ..Sympathetic overactivity is reported to cause sudden death, so carvedilol may be a first-line drug for some patients with ARVC...
  40. ncbi request reprint The use of a supercooling refrigerator improves the preservation of organ grafts
    Koshiro Monzen
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Bunkyo ku, Japan
    Biochem Biophys Res Commun 337:534-9. 2005
    ..Our results suggest that the use of this supercooling refrigerator improves organ preservation and may provide an innovative technique for human organ transplantation...
  41. ncbi request reprint Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome
    Kazuo Hara
    Department of Metabolic Diseases, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Diabetes Care 29:1357-62. 2006
    ....
  42. ncbi request reprint New insights in the treatment strategy for pulmonary arterial hypertension
    Makoto Sahara
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Cardiovasc Drugs Ther 20:377-86. 2006
    ..Considering these circumstances, it is necessary to develop additional novel therapeutic approaches that target the various components of this multifactorial disease...
  43. doi request reprint Infective endocarditis by Bartonella quintana masquerading as antineutrophil cytoplasmic antibody-associated small vessel vasculitis
    Hiroaki Sugiyama
    Department of Cardiovascular Medicine, University of Tokyo Hospital, Tokyo, Japan
    Cardiology 114:208-11. 2009
    ..Both a serological test for Bartonella and polymerase chain reaction restriction fragment length polymorphism analysis were helpful for a correct diagnosis and appropriate treatment...
  44. ncbi request reprint Supraventricular tachycardia originating from the posterior atrioventricular node in the univentricular heart with single atrium
    Kohsuke Ajiki
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Japan
    Int Heart J 48:253-9. 2007
    ..Radiofrequency catheter ablation applied to the posterior HBE eliminated the SVT...
  45. ncbi request reprint Deficiency of protein S-mediated familial venous thrombophilia--a case report
    Tomohiro Harada
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Angiology 54:377-81. 2003
    ..In the latter part, the aspects of risks for thromboembolism, potential problems in gestational period, and an advisability of thromboprophylaxis in patients with deficiency of protein S are described...
  46. ncbi request reprint Subarachnoid hemorrhage from mycotic aneurysms
    Tsutomu Shimizu
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
    Intern Med 45:1189-90. 2006
  47. pmc Genome-wide association study of coronary artery disease
    Naomi Ogawa
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo 113 8655, Japan
    Int J Hypertens 2010:790539. 2010
    ....
  48. pmc Impacts of patient characteristics on the effectiveness of landiolol in AF/AFL patients complicated with LV dysfunction: Subgroup analysis of the J-Land study
    Koichiro Kinugawa
    Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Adv Ther 31:426-39. 2014
    ..The subgroup analysis for patient characteristics was conducted to evaluate the impact on the efficacy and safety of landiolol compared with digoxin...
  49. ncbi request reprint Convenient single-nucleotide polymorphism typing from whole blood by probe extension and bioluminescence detection
    Yukie Nakashima
    Central Research Laboratory, Hitachi Ltd, Tokyo, Japan
    Clin Chem 50:1417-20. 2004
  50. pmc Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain
    Saku Miyamoto
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Cell Biol 23:8528-41. 2003
    ....
  51. ncbi request reprint Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
    Takayuki Shindo
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Nat Med 8:856-63. 2002
    ..KLF5 thus seems to be a key element linking external stress and cardiovascular remodeling...
  52. ncbi request reprint Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis
    Toshimasa Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Japan
    J Biol Chem 278:2461-8. 2003
    ..In conclusion, replenishment of globular adiponectin may provide a novel treatment modality for both type 2 diabetes and atherosclerosis...
  53. ncbi request reprint A 70-year-old woman with cardiogenic shock and change in acute electrocardiogram patterns. Left main shock syndrome/acute LMT occlusion
    Tomohiro Harada
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo
    J Cardiol 40:37-40. 2002