Affiliation: University of Tokyo
Ikeda H, Satoh H, Yanase M, Inoue Y, Tomiya T, Arai M, et al
. Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5. Gastroenterology. 2003;124:459-69 pubmed
..S1P has an antiproliferative property in rat hepatocytes by activating Rho via Edg-5. Our results raise the possibility that S1P is a negative regulator in liver regeneration. ..
Uetake Y, Ikeda H, Irie R, Tejima K, Matsui H, Ogura S, et al
. High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice. Lipids Health Dis. 2015;14:6 pubmed publisher
Ikeda H, Yatomi Y, Yanase M, Satoh H, Maekawa H, Ogata I, et al
. Biological activities of novel lipid mediator sphingosine 1-phosphate in rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2000;279:G304-10 pubmed
..Considering that HSCs are capable of production of extracellular matrices and modulation of blood flow in sinusoids, our results suggest that S-1-P may play a role in wound healing process in the liver...
Ikeda H, Ohkawa R, Watanabe N, Nakamura K, Kume Y, Nakagawa H, et al
. Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C. Clin Chim Acta. 2010;411:765-70 pubmed publisher
..Because our previous evidence suggests that S1P is involved in liver pathophysiology, we examined plasma S1P concentration in chronic hepatitis C patients...
Kondo M, Ishizawa T, Enooku K, Tokuhara Y, Ohkawa R, Uranbileg B, et al
. Increased serum autotaxin levels in hepatocellular carcinoma patients were caused by background liver fibrosis but not by carcinoma. Clin Chim Acta. 2014;433:128-34 pubmed publisher
..The increase in serum ATX levels in HCC patients may not be caused by abundant ATX production in HCC tissues but by fibrosis in the background livers. ..
Kurano M, Hara M, Tsuneyama K, Sakoda H, Shimizu T, Tsukamoto K, et al
. Induction of insulin secretion by apolipoprotein M, a carrier for sphingosine 1-phosphate. Biochim Biophys Acta. 2014;1841:1217-26 pubmed publisher
..ApoM augmented insulin secretion by maintaining the S1P concentration under both in vivo and in vitro conditions. ..
Uranbileg B, Nishikawa T, Ikeda H, Kurano M, Sato M, Saigusa D, et al
. Evidence Suggests Sphingosine 1-Phosphate Might Be Actively Generated, Degraded, and Transported to Extracellular Spaces With Increased S1P2 and S1P3 Expression in Colon Cancer. Clin Colorectal Cancer. 2018;17:e171-e182 pubmed publisher
..This altered S1P metabolism might play a role in colon cancer pathophysiology. ..