Yoshio Hosoi

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Induction of interleukin-1beta and interleukin-6 mRNA by low doses of ionizing radiation in macrophages
    Y Hosoi
    Department of Radiation Oncology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyoku, Tokyo 113 0033, Japan
    Int J Cancer 96:270-6. 2001
  2. ncbi request reprint Suramin sensitizing cells to ionizing radiation by inactivating DNA-dependent protein kinase
    Yoshio Hosoi
    Department of Radiation Oncology, Faculty of Medicine, University of Tokyo, Japan
    Radiat Res 162:308-14. 2004
  3. ncbi request reprint Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer
    Yoshio Hosoi
    Department of Radiation Research, Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Int J Oncol 25:461-8. 2004
  4. ncbi request reprint Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC
    Yoshio Hosoi
    Department of Radiation Research, Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 348:728-34. 2006
  5. ncbi request reprint [Antitumor effects by low dose total body irradiation]
    Yoshio Hosoi
    Section of Radiation Biology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Japan
    Yakugaku Zasshi 126:841-8. 2006
  6. pmc Phosphorothioate oligonucleotides, suramin and heparin inhibit DNA-dependent protein kinase activity
    Y Hosoi
    Department of Radiation Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Br J Cancer 86:1143-9. 2002
  7. ncbi request reprint Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation
    Zhiping Li
    Department of Radiation Research, Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 341:363-8. 2006
  8. ncbi request reprint Free radical scavenger edaravone suppresses x-ray-induced apoptosis through p53 inhibition in MOLT-4 cells
    Nakashi Sasano
    Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Radiat Res 48:495-503. 2007
  9. doi request reprint Preoperative radiation response evaluated by 18-fluorodeoxyglucose positron emission tomography predicts survival in locally advanced rectal cancer
    Keiichi Nakagawa
    Department of Radiology, University of Tokyo Hospital, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Dis Colon Rectum 51:1055-60. 2008
  10. ncbi request reprint Prognostic significance of Ku70 protein expression in patients with advanced colorectal cancer
    Yasuhiro Komuro
    Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Japan
    Hepatogastroenterology 52:995-8. 2005

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Induction of interleukin-1beta and interleukin-6 mRNA by low doses of ionizing radiation in macrophages
    Y Hosoi
    Department of Radiation Oncology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyoku, Tokyo 113 0033, Japan
    Int J Cancer 96:270-6. 2001
    ....
  2. ncbi request reprint Suramin sensitizing cells to ionizing radiation by inactivating DNA-dependent protein kinase
    Yoshio Hosoi
    Department of Radiation Oncology, Faculty of Medicine, University of Tokyo, Japan
    Radiat Res 162:308-14. 2004
    ..Suramin's effects were not caused by accumulation of cells in a specific phase of the cell cycle. These results suggest that suramin sensitizes cells to ionizing radiation by inhibiting DNA-dependent protein kinase activity...
  3. ncbi request reprint Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer
    Yoshio Hosoi
    Department of Radiation Research, Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Int J Oncol 25:461-8. 2004
    ..These results suggest that DNA-PK activity and protein- and mRNA-levels of Ku70, Ku80 and DNA-PKcs were elevated in tumor tissues in patients with colorectal cancer because of elevated Sp1 protein levels in tumor tissues...
  4. ncbi request reprint Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC
    Yoshio Hosoi
    Department of Radiation Research, Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 348:728-34. 2006
    ..Colony-forming efficiency in soft agar was significantly suppressed in all of the ATDC transfectants. These results suggest that suppressed ATDC expression is associated with malignant phenotype...
  5. ncbi request reprint [Antitumor effects by low dose total body irradiation]
    Yoshio Hosoi
    Section of Radiation Biology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Japan
    Yakugaku Zasshi 126:841-8. 2006
    ....
  6. pmc Phosphorothioate oligonucleotides, suramin and heparin inhibit DNA-dependent protein kinase activity
    Y Hosoi
    Department of Radiation Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Br J Cancer 86:1143-9. 2002
    ..Our present observations suggest that suramin may possibly result in sensitisation of cells to ionising radiation by inactivation of DNA-dependent protein kinase and the impairment of double-stranded breaks repair...
  7. ncbi request reprint Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation
    Zhiping Li
    Department of Radiation Research, Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 341:363-8. 2006
    ..These data suggest that IR-induced ERK1/2 activation involves EGFR through a Src-dependent pathway that is distinct from EGFR ligand activation...
  8. ncbi request reprint Free radical scavenger edaravone suppresses x-ray-induced apoptosis through p53 inhibition in MOLT-4 cells
    Nakashi Sasano
    Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Radiat Res 48:495-503. 2007
    ..We conclude that the free radical scavenger edaravone suppresses X-ray-induced apoptosis in MOLT-4 cells by inhibiting p53...
  9. doi request reprint Preoperative radiation response evaluated by 18-fluorodeoxyglucose positron emission tomography predicts survival in locally advanced rectal cancer
    Keiichi Nakagawa
    Department of Radiology, University of Tokyo Hospital, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Dis Colon Rectum 51:1055-60. 2008
    ..This study focuses on the prognostic survival value of postirradiation metabolic activity in primary rectal cancer as measured with 18-fluorodeoxyglucose positron emission tomography...
  10. ncbi request reprint Prognostic significance of Ku70 protein expression in patients with advanced colorectal cancer
    Yasuhiro Komuro
    Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Japan
    Hepatogastroenterology 52:995-8. 2005
    ..However, in colorectal carcinoma, the clinical significance of Ku70 expression remains unclear. We examined the expression pattern of Ku70 in sporadic colorectal cancer and its relation to clinicopathological parameters and survival...
  11. ncbi request reprint Radiosensitization by hyperthermia in the chicken B-lymphocyte cell line DT40 and its derivatives lacking nonhomologous end joining and/or homologous recombination pathways of DNA double-strand break repair
    Hong Lan Yin
    Department of Radiation Research, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    Radiat Res 162:433-41. 2004
    ..Thus partial contribution of NHEJ and HR in radiosensitization by hyperthermia, especially that depending on the cell cycle stage, remains to be considered...
  12. ncbi request reprint Potentiality of DNA-dependent protein kinase to phosphorylate Ser46 of human p53
    Shingo Komiyama
    Department of Radiation Oncology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 323:816-22. 2004
    ..These results collectively suggested two pathways for IR-induced phosphorylation of Ser46, i.e., direct phosphorylation by DNA-PK and indirect phosphorylation via ATM...
  13. doi request reprint Umami taste dysfunction in patients receiving radiotherapy for head and neck cancer
    Hideomi Yamashita
    Department of Radiology, University of Tokyo Hospital, Bunkyou ku, Tokyo, Japan
    Oral Oncol 45:e19-23. 2009
    ..Umami taste declined of the 3rd week after the start of radiotherapy and improved of the 8th week...
  14. ncbi request reprint Wortmannin-enhanced X-ray-induced apoptosis of human T-cell leukemia MOLT-4 cells possibly through the JNK/SAPK pathway
    Masanori Tomita
    Department of Radiation Oncology, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Radiat Res 160:467-77. 2003
    ..The suppression of the AKT-dependent pathway by wortmannin may have some underlying role in activating the JNK pathway toward the enhancement of cell death in the current system...
  15. doi request reprint The HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin modulates radiosensitivity by downregulating serine/threonine kinase 38 via Sp1 inhibition
    Atsushi Enomoto
    Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan Electronic address
    Eur J Cancer 49:3547-58. 2013
    ..Moreover, 17-AAG treatment or STK38 knockdown enhanced the radiosensitivity of HeLa cells. Our data provide a novel mechanism, mediated by stk38 downregulation, by which 17-AAG radiosensitizes cells. ..
  16. ncbi request reprint The expression pattern of Ku correlates with tumor radiosensitivity and disease free survival in patients with rectal carcinoma
    Yasuhiro Komuro
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Japan
    Cancer 95:1199-205. 2002
    ..The authors examined the possible role of Ku protein in determining tumor radiosensitivity and disease free survival in patients with rectal carcinoma...
  17. ncbi request reprint Caspase-mediated cleavage of JNK during stress-induced apoptosis
    Atsushi Enomoto
    Department of Radiation Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 306:837-42. 2003
    ..Altogether, our results demonstrated that p54 JNKs, at least JNK1beta2 and JNK2beta2, were new selective targets of caspases in JNK splicing variants, and suggested that the p52 form could serve as a marker of apoptosis...
  18. ncbi request reprint Radiation therapy for portal venous invasion by hepatocellular carcinoma
    Keiichi Nakagawa
    Department of Radiology, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    World J Gastroenterol 11:7237-41. 2005
    ..To clarify the efficacy and safety of three-dimensional conformal radiotherapy (3-D CRT) for this disease and to specify patient subgroups suitable for this treatment...
  19. ncbi request reprint Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-mura criticality accident
    Hiroshi Igaki
    Department of Radiology, University of Tokyo Hospital, Tokyo, Japan
    J Radiat Res 49:55-62. 2008
    ..This is the first report documenting the relationship between the absorbed dose and the severity of gastrointestinal damages in vivo...
  20. ncbi request reprint Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium
    Norio Tonotsuka
    Department of Radiation Research, Faculty of Medicine, Tohoku University, Sendai 980 8575, Japan
    Int J Mol Med 18:441-7. 2006
    ....
  21. ncbi request reprint Relation between acute and late irradiation impairment of four basic tastes and irradiated tongue volume in patients with head-and-neck cancer
    Hideomi Yamashita
    Department of Radiology, University of Tokyo Hospital, Tokyo, Japan
    Int J Radiat Oncol Biol Phys 66:1422-9. 2006
    ..Taste loss is a major cause of morbidity in patients undergoing head-and-neck irradiation. The relationship between the time course and the degree of taste disorder was studied in both acute and late phases...
  22. pmc Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA- dependent protein kinase complex in an isoform-dependent manner
    Satoko Oyama
    Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Meguro ku, Tokyo, Japan
    PLoS ONE 4:e4199. 2009
    ....
  23. ncbi request reprint Spontaneous mutations in digestive tract of old mice show tissue-specific patterns of genomic instability
    Tetsuya Ono
    Division of Genome and Radiation Biology, Graduate School of Medicine, Tohoku University, Sendai, Japan
    Cancer Res 64:6919-23. 2004
    ..The nature of the multiple mutations suggests the presence of a mutator phenotype based on an imbalance in deoxyribonucleotide pools...
  24. ncbi request reprint Intercomparison of dose distribution between gamma knife and C-arm-mounted linac
    Keiichi Nakagawa
    Department of Radiology, University of Tokyo School of Medicine, Tokyo, Japan
    Radiat Med 21:178-82. 2003
    ....
  25. ncbi request reprint Insulin-like growth factor I receptor is expressed at normal levels in Nijmegen breakage syndrome cells
    Hiroshi Watanabe
    Oral and Maxillofacial Radiology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8549, Tokyo, Japan
    Biochem Biophys Res Commun 296:62-6. 2002
    ..Collectively, IGF-IR-related events are unlikely to be disrupted in NBS cells, and therefore, defects in IGF-IR signaling do not explain the increased radiosensitivity of NBS cells...
  26. ncbi request reprint The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer
    Masanori Someya
    Department of Radiology, Sapporo Medical University, School of Medicine, Hokkaido, Japan
    Carcinogenesis 27:117-22. 2006
    ..DNA-PK activity in PBL can be used to select individuals for whom an examination should be performed because of their increased susceptibility to breast and uterine cervix cancer...
  27. ncbi request reprint Effect of nitric oxide on gamma-ray-induced micronucleus frequency in RAW264.7 cells
    Sachiko Tokuzumi
    Department of Radiation Bioscience, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda shi, Chiba 278 8510, Japan
    Radiat Res 164:723-32. 2005
    ..NO may act as a signal for repair systems, e.g. for nonhomologous recombination and for the replication system in S phase, to reduce the MN frequency...